-- dump date 20140620_070146 -- class Genbank::misc_feature -- table misc_feature_note -- id note 366394000001 Dtr system oriT relaxase; Provisional; Region: PRK13826 366394000002 MobA/MobL family; Region: MobA_MobL; pfam03389 366394000003 AAA domain; Region: AAA_30; pfam13604 366394000004 Family description; Region: UvrD_C_2; pfam13538 366394000005 K+ potassium transporter; Region: K_trans; cl15781 366394000006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 366394000007 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394000008 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394000009 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394000010 DNA binding site [nucleotide binding] 366394000011 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394000012 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 366394000013 ligand binding site [chemical binding]; other site 366394000014 dimerization interface [polypeptide binding]; other site 366394000015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289 366394000016 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 366394000017 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 366394000018 putative ligand binding site [chemical binding]; other site 366394000019 putative NAD binding site [chemical binding]; other site 366394000020 catalytic site [active] 366394000021 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 366394000022 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 366394000023 RES domain; Region: RES; smart00953 366394000024 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394000025 classical (c) SDRs; Region: SDR_c; cd05233 366394000026 NAD(P) binding site [chemical binding]; other site 366394000027 active site 366394000028 Transcriptional regulator [Transcription]; Region: IclR; COG1414 366394000029 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 366394000030 Bacterial transcriptional regulator; Region: IclR; pfam01614 366394000031 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 366394000032 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394000033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394000034 NAD(P) binding site [chemical binding]; other site 366394000035 active site 366394000036 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394000037 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394000038 Walker A/P-loop; other site 366394000039 ATP binding site [chemical binding]; other site 366394000040 Q-loop/lid; other site 366394000041 ABC transporter signature motif; other site 366394000042 Walker B; other site 366394000043 D-loop; other site 366394000044 H-loop/switch region; other site 366394000045 TOBE domain; Region: TOBE_2; pfam08402 366394000046 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394000047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000048 dimer interface [polypeptide binding]; other site 366394000049 conserved gate region; other site 366394000050 putative PBP binding loops; other site 366394000051 ABC-ATPase subunit interface; other site 366394000052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000053 dimer interface [polypeptide binding]; other site 366394000054 conserved gate region; other site 366394000055 putative PBP binding loops; other site 366394000056 ABC-ATPase subunit interface; other site 366394000057 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394000058 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394000059 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 366394000060 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 366394000061 active site pocket [active] 366394000062 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 366394000063 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 366394000064 inhibitor site; inhibition site 366394000065 active site 366394000066 dimer interface [polypeptide binding]; other site 366394000067 catalytic residue [active] 366394000068 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 366394000069 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 366394000070 short chain dehydrogenase; Provisional; Region: PRK07063 366394000071 classical (c) SDRs; Region: SDR_c; cd05233 366394000072 NAD(P) binding site [chemical binding]; other site 366394000073 active site 366394000074 galactonate dehydratase; Provisional; Region: PRK14017 366394000075 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 366394000076 putative active site pocket [active] 366394000077 putative metal binding site [ion binding]; other site 366394000078 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394000079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394000080 DNA-binding site [nucleotide binding]; DNA binding site 366394000081 FCD domain; Region: FCD; pfam07729 366394000082 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 366394000083 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 366394000084 ligand binding site [chemical binding]; other site 366394000085 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 366394000086 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394000087 Walker A/P-loop; other site 366394000088 ATP binding site [chemical binding]; other site 366394000089 Q-loop/lid; other site 366394000090 ABC transporter signature motif; other site 366394000091 Walker B; other site 366394000092 D-loop; other site 366394000093 H-loop/switch region; other site 366394000094 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394000095 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394000096 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394000097 TM-ABC transporter signature motif; other site 366394000098 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394000099 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 366394000100 ligand binding site [chemical binding]; other site 366394000101 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394000102 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394000103 Walker A/P-loop; other site 366394000104 ATP binding site [chemical binding]; other site 366394000105 Q-loop/lid; other site 366394000106 ABC transporter signature motif; other site 366394000107 Walker B; other site 366394000108 D-loop; other site 366394000109 H-loop/switch region; other site 366394000110 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394000111 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394000112 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394000113 TM-ABC transporter signature motif; other site 366394000114 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 366394000115 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 366394000116 DNA binding residues [nucleotide binding] 366394000117 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 366394000118 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394000119 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394000120 active site 366394000121 catalytic tetrad [active] 366394000122 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 366394000123 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 366394000124 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 366394000125 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 366394000126 putative active site; other site 366394000127 catalytic residue [active] 366394000128 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 366394000129 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 366394000130 putative N- and C-terminal domain interface [polypeptide binding]; other site 366394000131 putative active site [active] 366394000132 MgATP binding site [chemical binding]; other site 366394000133 catalytic site [active] 366394000134 metal binding site [ion binding]; metal-binding site 366394000135 putative xylulose binding site [chemical binding]; other site 366394000136 choline dehydrogenase; Validated; Region: PRK02106 366394000137 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 366394000138 Double zinc ribbon; Region: DZR; pfam12773 366394000139 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 366394000140 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394000141 cyclase homology domain; Region: CHD; cd07302 366394000142 nucleotidyl binding site; other site 366394000143 metal binding site [ion binding]; metal-binding site 366394000144 dimer interface [polypeptide binding]; other site 366394000145 Predicted ATPase [General function prediction only]; Region: COG3899 366394000146 AAA ATPase domain; Region: AAA_16; pfam13191 366394000147 Tetratricopeptide repeat; Region: TPR_12; pfam13424 366394000148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394000149 TPR motif; other site 366394000150 binding surface 366394000151 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 366394000152 putative catalytic residues [active] 366394000153 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 366394000154 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 366394000155 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 366394000156 4Fe-4S binding domain; Region: Fer4; pfam00037 366394000157 FOG: CBS domain [General function prediction only]; Region: COG0517 366394000158 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 366394000159 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 366394000160 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394000161 catalytic loop [active] 366394000162 iron binding site [ion binding]; other site 366394000163 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 366394000164 4Fe-4S binding domain; Region: Fer4; pfam00037 366394000165 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 366394000166 [4Fe-4S] binding site [ion binding]; other site 366394000167 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 366394000168 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 366394000169 SLBB domain; Region: SLBB; pfam10531 366394000170 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 366394000171 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 366394000172 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 366394000173 putative dimer interface [polypeptide binding]; other site 366394000174 [2Fe-2S] cluster binding site [ion binding]; other site 366394000175 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 366394000176 NADH dehydrogenase subunit D; Validated; Region: PRK06075 366394000177 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 366394000178 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 366394000179 NADH dehydrogenase subunit B; Validated; Region: PRK06411 366394000180 NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838 366394000181 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 366394000182 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 366394000183 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 366394000184 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 366394000185 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 366394000186 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 366394000187 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 366394000188 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 366394000189 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 366394000190 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 366394000191 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 366394000192 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 366394000193 intersubunit interface [polypeptide binding]; other site 366394000194 active site 366394000195 Zn2+ binding site [ion binding]; other site 366394000196 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 366394000197 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 366394000198 N- and C-terminal domain interface [polypeptide binding]; other site 366394000199 putative active site [active] 366394000200 putative MgATP binding site [chemical binding]; other site 366394000201 putative catalytic site [active] 366394000202 metal binding site [ion binding]; metal-binding site 366394000203 putative carbohydrate binding site [chemical binding]; other site 366394000204 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 366394000205 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 366394000206 Metal-binding active site; metal-binding site 366394000207 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394000208 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394000209 TM-ABC transporter signature motif; other site 366394000210 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394000211 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394000212 TM-ABC transporter signature motif; other site 366394000213 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394000214 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394000215 Walker A/P-loop; other site 366394000216 ATP binding site [chemical binding]; other site 366394000217 Q-loop/lid; other site 366394000218 ABC transporter signature motif; other site 366394000219 Walker B; other site 366394000220 D-loop; other site 366394000221 H-loop/switch region; other site 366394000222 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394000223 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 366394000224 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 366394000225 ligand binding site [chemical binding]; other site 366394000226 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394000227 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 366394000228 dimerization interface [polypeptide binding]; other site 366394000229 ligand binding site [chemical binding]; other site 366394000230 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 366394000231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394000232 Coenzyme A binding pocket [chemical binding]; other site 366394000233 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 366394000234 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 366394000235 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 366394000236 active site 366394000237 dimer interface [polypeptide binding]; other site 366394000238 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 366394000239 Ligand Binding Site [chemical binding]; other site 366394000240 Molecular Tunnel; other site 366394000241 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394000242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394000243 DNA-binding site [nucleotide binding]; DNA binding site 366394000244 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 366394000245 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 366394000246 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394000247 Walker A/P-loop; other site 366394000248 ATP binding site [chemical binding]; other site 366394000249 Q-loop/lid; other site 366394000250 ABC transporter signature motif; other site 366394000251 Walker B; other site 366394000252 D-loop; other site 366394000253 H-loop/switch region; other site 366394000254 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394000255 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 366394000256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000257 dimer interface [polypeptide binding]; other site 366394000258 conserved gate region; other site 366394000259 putative PBP binding loops; other site 366394000260 ABC-ATPase subunit interface; other site 366394000261 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394000262 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 366394000263 Walker A/P-loop; other site 366394000264 ATP binding site [chemical binding]; other site 366394000265 Q-loop/lid; other site 366394000266 ABC transporter signature motif; other site 366394000267 Walker B; other site 366394000268 D-loop; other site 366394000269 H-loop/switch region; other site 366394000270 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394000271 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394000272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000273 dimer interface [polypeptide binding]; other site 366394000274 conserved gate region; other site 366394000275 putative PBP binding loops; other site 366394000276 ABC-ATPase subunit interface; other site 366394000277 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394000278 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 366394000279 peptide binding site [polypeptide binding]; other site 366394000280 Predicted membrane protein [Function unknown]; Region: COG1238 366394000281 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 366394000282 active site residue [active] 366394000283 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 366394000284 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 366394000285 Chromate transporter; Region: Chromate_transp; pfam02417 366394000286 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394000287 classical (c) SDRs; Region: SDR_c; cd05233 366394000288 NAD(P) binding site [chemical binding]; other site 366394000289 active site 366394000290 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394000291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394000292 NAD(P) binding site [chemical binding]; other site 366394000293 active site 366394000294 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 366394000295 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 366394000296 ligand binding site [chemical binding]; other site 366394000297 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 366394000298 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394000299 Walker A/P-loop; other site 366394000300 ATP binding site [chemical binding]; other site 366394000301 Q-loop/lid; other site 366394000302 ABC transporter signature motif; other site 366394000303 Walker B; other site 366394000304 D-loop; other site 366394000305 H-loop/switch region; other site 366394000306 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394000307 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394000308 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 366394000309 TM-ABC transporter signature motif; other site 366394000310 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394000311 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 366394000312 TM-ABC transporter signature motif; other site 366394000313 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 366394000314 active site 366394000315 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 366394000316 active site 366394000317 tetramer interface [polypeptide binding]; other site 366394000318 Isochorismatase family; Region: Isochorismatase; pfam00857 366394000319 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 366394000320 catalytic triad [active] 366394000321 conserved cis-peptide bond; other site 366394000322 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 366394000323 MarR family; Region: MarR; pfam01047 366394000324 Amino acid synthesis; Region: AA_synth; pfam06684 366394000325 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 366394000326 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 366394000327 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 366394000328 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 366394000329 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 366394000330 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 366394000331 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 366394000332 putative oligomer interface [polypeptide binding]; other site 366394000333 putative active site [active] 366394000334 metal binding site [ion binding]; metal-binding site 366394000335 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 366394000336 nucleotide binding site [chemical binding]; other site 366394000337 Protein of unknown function (DUF995); Region: DUF995; pfam06191 366394000338 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 366394000339 Protein of unknown function (DUF995); Region: DUF995; pfam06191 366394000340 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 366394000341 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 366394000342 active site 366394000343 Cellulose synthase-like protein; Region: PLN02893 366394000344 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 366394000345 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 366394000346 NAD binding site [chemical binding]; other site 366394000347 homodimer interface [polypeptide binding]; other site 366394000348 active site 366394000349 substrate binding site [chemical binding]; other site 366394000350 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394000351 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 366394000352 NAD binding site [chemical binding]; other site 366394000353 putative substrate binding site 2 [chemical binding]; other site 366394000354 putative substrate binding site 1 [chemical binding]; other site 366394000355 active site 366394000356 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 366394000357 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394000358 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 366394000359 classical (c) SDRs; Region: SDR_c; cd05233 366394000360 NAD(P) binding site [chemical binding]; other site 366394000361 active site 366394000362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394000363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394000364 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 366394000365 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 366394000366 anti sigma factor interaction site; other site 366394000367 regulatory phosphorylation site [posttranslational modification]; other site 366394000368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 366394000369 Cache domain; Region: Cache_1; pfam02743 366394000370 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 366394000371 dimerization interface [polypeptide binding]; other site 366394000372 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 366394000373 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 366394000374 Uncharacterized conserved protein [Function unknown]; Region: COG5439 366394000375 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 366394000376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394000377 S-adenosylmethionine binding site [chemical binding]; other site 366394000378 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394000379 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394000380 metal binding site [ion binding]; metal-binding site 366394000381 active site 366394000382 I-site; other site 366394000383 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 366394000384 mannonate dehydratase; Provisional; Region: PRK03906 366394000385 mannonate dehydratase; Region: uxuA; TIGR00695 366394000386 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 366394000387 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 366394000388 putative NAD(P) binding site [chemical binding]; other site 366394000389 catalytic Zn binding site [ion binding]; other site 366394000390 DctM-like transporters; Region: DctM; pfam06808 366394000391 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 366394000392 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 366394000393 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 366394000394 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 366394000395 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394000396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394000397 DNA-binding site [nucleotide binding]; DNA binding site 366394000398 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 366394000399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394000400 putative substrate translocation pore; other site 366394000401 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394000402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394000403 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394000404 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 366394000405 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 366394000406 putative active site [active] 366394000407 Zn binding site [ion binding]; other site 366394000408 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 366394000409 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 366394000410 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 366394000411 active site 366394000412 ectoine utilization protein EutC; Validated; Region: PRK08291 366394000413 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 366394000414 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 366394000415 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 366394000416 tetramer interface [polypeptide binding]; other site 366394000417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394000418 catalytic residue [active] 366394000419 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 366394000420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000421 dimer interface [polypeptide binding]; other site 366394000422 conserved gate region; other site 366394000423 putative PBP binding loops; other site 366394000424 ABC-ATPase subunit interface; other site 366394000425 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 366394000426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000427 dimer interface [polypeptide binding]; other site 366394000428 conserved gate region; other site 366394000429 putative PBP binding loops; other site 366394000430 ABC-ATPase subunit interface; other site 366394000431 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 366394000432 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394000433 substrate binding pocket [chemical binding]; other site 366394000434 membrane-bound complex binding site; other site 366394000435 hinge residues; other site 366394000436 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 366394000437 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 366394000438 Walker A/P-loop; other site 366394000439 ATP binding site [chemical binding]; other site 366394000440 Q-loop/lid; other site 366394000441 ABC transporter signature motif; other site 366394000442 Walker B; other site 366394000443 D-loop; other site 366394000444 H-loop/switch region; other site 366394000445 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 366394000446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394000447 DNA-binding site [nucleotide binding]; DNA binding site 366394000448 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394000449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394000450 homodimer interface [polypeptide binding]; other site 366394000451 catalytic residue [active] 366394000452 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 366394000453 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394000454 putative DNA binding site [nucleotide binding]; other site 366394000455 putative Zn2+ binding site [ion binding]; other site 366394000456 AsnC family; Region: AsnC_trans_reg; pfam01037 366394000457 succinic semialdehyde dehydrogenase; Region: PLN02278 366394000458 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 366394000459 tetramerization interface [polypeptide binding]; other site 366394000460 NAD(P) binding site [chemical binding]; other site 366394000461 catalytic residues [active] 366394000462 hypothetical protein; Provisional; Region: PRK07482 366394000463 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 366394000464 inhibitor-cofactor binding pocket; inhibition site 366394000465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394000466 catalytic residue [active] 366394000467 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 366394000468 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 366394000469 putative NAD(P) binding site [chemical binding]; other site 366394000470 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394000471 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 366394000472 putative C-terminal domain interface [polypeptide binding]; other site 366394000473 putative GSH binding site (G-site) [chemical binding]; other site 366394000474 putative dimer interface [polypeptide binding]; other site 366394000475 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 366394000476 dimer interface [polypeptide binding]; other site 366394000477 N-terminal domain interface [polypeptide binding]; other site 366394000478 putative substrate binding pocket (H-site) [chemical binding]; other site 366394000479 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394000480 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394000481 Walker A/P-loop; other site 366394000482 ATP binding site [chemical binding]; other site 366394000483 Q-loop/lid; other site 366394000484 ABC transporter signature motif; other site 366394000485 Walker B; other site 366394000486 D-loop; other site 366394000487 H-loop/switch region; other site 366394000488 TOBE domain; Region: TOBE_2; pfam08402 366394000489 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394000490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000491 dimer interface [polypeptide binding]; other site 366394000492 conserved gate region; other site 366394000493 ABC-ATPase subunit interface; other site 366394000494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 366394000495 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 366394000496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000497 dimer interface [polypeptide binding]; other site 366394000498 conserved gate region; other site 366394000499 putative PBP binding loops; other site 366394000500 ABC-ATPase subunit interface; other site 366394000501 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394000502 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394000503 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 366394000504 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 366394000505 putative NAD(P) binding site [chemical binding]; other site 366394000506 active site 366394000507 DoxX-like family; Region: DoxX_3; pfam13781 366394000508 Predicted integral membrane protein [Function unknown]; Region: COG5528 366394000509 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 366394000510 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 366394000511 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 366394000512 classical (c) SDRs; Region: SDR_c; cd05233 366394000513 NAD(P) binding site [chemical binding]; other site 366394000514 active site 366394000515 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 366394000516 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 366394000517 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 366394000518 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 366394000519 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 366394000520 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 366394000521 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 366394000522 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394000523 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394000524 DNA binding residues [nucleotide binding] 366394000525 dimerization interface [polypeptide binding]; other site 366394000526 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394000527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394000528 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394000529 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 366394000530 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 366394000531 putative active site [active] 366394000532 putative metal binding site [ion binding]; other site 366394000533 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 366394000534 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 366394000535 dimer interface [polypeptide binding]; other site 366394000536 catalytic residue [active] 366394000537 metal binding site [ion binding]; metal-binding site 366394000538 transcriptional regulator NanR; Provisional; Region: PRK03837 366394000539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394000540 DNA-binding site [nucleotide binding]; DNA binding site 366394000541 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 366394000542 FCD domain; Region: FCD; pfam07729 366394000543 Cellulose synthase-like protein; Region: PLN02893 366394000544 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 366394000545 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 366394000546 DXD motif; other site 366394000547 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 366394000548 GAF domain; Region: GAF; pfam01590 366394000549 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 366394000550 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394000551 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394000552 metal binding site [ion binding]; metal-binding site 366394000553 active site 366394000554 I-site; other site 366394000555 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 366394000556 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 366394000557 NAD(P) binding site [chemical binding]; other site 366394000558 Transcriptional regulator [Transcription]; Region: IclR; COG1414 366394000559 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 366394000560 Bacterial transcriptional regulator; Region: IclR; pfam01614 366394000561 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 366394000562 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 366394000563 active site 366394000564 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 366394000565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 366394000566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000567 dimer interface [polypeptide binding]; other site 366394000568 putative PBP binding loops; other site 366394000569 ABC-ATPase subunit interface; other site 366394000570 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394000571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000572 dimer interface [polypeptide binding]; other site 366394000573 conserved gate region; other site 366394000574 putative PBP binding loops; other site 366394000575 ABC-ATPase subunit interface; other site 366394000576 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394000577 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 366394000578 Walker A/P-loop; other site 366394000579 ATP binding site [chemical binding]; other site 366394000580 Q-loop/lid; other site 366394000581 ABC transporter signature motif; other site 366394000582 Walker B; other site 366394000583 D-loop; other site 366394000584 H-loop/switch region; other site 366394000585 TOBE domain; Region: TOBE_2; pfam08402 366394000586 aminotransferase; Provisional; Region: PRK06105 366394000587 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 366394000588 inhibitor-cofactor binding pocket; inhibition site 366394000589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394000590 catalytic residue [active] 366394000591 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 366394000592 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 366394000593 tetramerization interface [polypeptide binding]; other site 366394000594 NAD(P) binding site [chemical binding]; other site 366394000595 catalytic residues [active] 366394000596 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 366394000597 homotrimer interaction site [polypeptide binding]; other site 366394000598 putative active site [active] 366394000599 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 366394000600 homotrimer interaction site [polypeptide binding]; other site 366394000601 putative active site [active] 366394000602 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394000603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394000604 DNA-binding site [nucleotide binding]; DNA binding site 366394000605 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 366394000606 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 366394000607 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 366394000608 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 366394000609 DctM-like transporters; Region: DctM; pfam06808 366394000610 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 366394000611 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 366394000612 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 366394000613 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 366394000614 Walker A/P-loop; other site 366394000615 ATP binding site [chemical binding]; other site 366394000616 Q-loop/lid; other site 366394000617 ABC transporter signature motif; other site 366394000618 Walker B; other site 366394000619 D-loop; other site 366394000620 H-loop/switch region; other site 366394000621 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 366394000622 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 366394000623 FtsX-like permease family; Region: FtsX; pfam02687 366394000624 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 366394000625 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394000626 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394000627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394000628 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394000629 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394000630 DNA binding site [nucleotide binding] 366394000631 domain linker motif; other site 366394000632 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 366394000633 putative dimerization interface [polypeptide binding]; other site 366394000634 putative ligand binding site [chemical binding]; other site 366394000635 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 366394000636 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 366394000637 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 366394000638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000639 dimer interface [polypeptide binding]; other site 366394000640 conserved gate region; other site 366394000641 putative PBP binding loops; other site 366394000642 ABC-ATPase subunit interface; other site 366394000643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000644 dimer interface [polypeptide binding]; other site 366394000645 conserved gate region; other site 366394000646 putative PBP binding loops; other site 366394000647 ABC-ATPase subunit interface; other site 366394000648 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394000649 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394000650 Walker A/P-loop; other site 366394000651 ATP binding site [chemical binding]; other site 366394000652 Q-loop/lid; other site 366394000653 ABC transporter signature motif; other site 366394000654 Walker B; other site 366394000655 D-loop; other site 366394000656 H-loop/switch region; other site 366394000657 TOBE domain; Region: TOBE_2; pfam08402 366394000658 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 366394000659 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 366394000660 active site 366394000661 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 366394000662 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 366394000663 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 366394000664 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 366394000665 putative NAD(P) binding site [chemical binding]; other site 366394000666 active site 366394000667 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 366394000668 Ion channel; Region: Ion_trans_2; pfam07885 366394000669 Predicted periplasmic protein [Function unknown]; Region: COG3904 366394000670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394000671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394000672 phosphorylation site [posttranslational modification] 366394000673 dimer interface [polypeptide binding]; other site 366394000674 Response regulator receiver domain; Region: Response_reg; pfam00072 366394000675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394000676 active site 366394000677 phosphorylation site [posttranslational modification] 366394000678 intermolecular recognition site; other site 366394000679 dimerization interface [polypeptide binding]; other site 366394000680 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 366394000681 cyclase homology domain; Region: CHD; cd07302 366394000682 nucleotidyl binding site; other site 366394000683 metal binding site [ion binding]; metal-binding site 366394000684 dimer interface [polypeptide binding]; other site 366394000685 Response regulator receiver domain; Region: Response_reg; pfam00072 366394000686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394000687 active site 366394000688 phosphorylation site [posttranslational modification] 366394000689 intermolecular recognition site; other site 366394000690 dimerization interface [polypeptide binding]; other site 366394000691 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 366394000692 dimerization interface [polypeptide binding]; other site 366394000693 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 366394000694 PAS domain; Region: PAS; smart00091 366394000695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394000696 dimer interface [polypeptide binding]; other site 366394000697 phosphorylation site [posttranslational modification] 366394000698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394000699 ATP binding site [chemical binding]; other site 366394000700 Mg2+ binding site [ion binding]; other site 366394000701 G-X-G motif; other site 366394000702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394000703 Response regulator receiver domain; Region: Response_reg; pfam00072 366394000704 active site 366394000705 phosphorylation site [posttranslational modification] 366394000706 intermolecular recognition site; other site 366394000707 dimerization interface [polypeptide binding]; other site 366394000708 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 366394000709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394000710 active site 366394000711 phosphorylation site [posttranslational modification] 366394000712 intermolecular recognition site; other site 366394000713 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 366394000714 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394000715 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394000716 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394000717 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394000718 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394000719 TM-ABC transporter signature motif; other site 366394000720 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394000721 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394000722 Walker A/P-loop; other site 366394000723 ATP binding site [chemical binding]; other site 366394000724 Q-loop/lid; other site 366394000725 ABC transporter signature motif; other site 366394000726 Walker B; other site 366394000727 D-loop; other site 366394000728 H-loop/switch region; other site 366394000729 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394000730 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5618 366394000731 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 366394000732 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 366394000733 ligand binding site [chemical binding]; other site 366394000734 dimerization interface [polypeptide binding]; other site 366394000735 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 366394000736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394000737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394000738 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 366394000739 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 366394000740 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394000741 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 366394000742 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 366394000743 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 366394000744 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394000745 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 366394000746 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394000747 catalytic loop [active] 366394000748 iron binding site [ion binding]; other site 366394000749 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 366394000750 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 366394000751 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 366394000752 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 366394000753 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 366394000754 RPAP1-like, C-terminal; Region: RPAP1_C; pfam08620 366394000755 Major Facilitator Superfamily; Region: MFS_1; pfam07690 366394000756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394000757 putative substrate translocation pore; other site 366394000758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394000759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394000760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 366394000761 Autotransporter beta-domain; Region: Autotransporter; pfam03797 366394000762 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 366394000763 Uncharacterized conserved protein [Function unknown]; Region: COG1262 366394000764 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 366394000765 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 366394000766 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 366394000767 Sulfatase; Region: Sulfatase; pfam00884 366394000768 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 366394000769 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 366394000770 Response regulator receiver domain; Region: Response_reg; pfam00072 366394000771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394000772 active site 366394000773 phosphorylation site [posttranslational modification] 366394000774 intermolecular recognition site; other site 366394000775 dimerization interface [polypeptide binding]; other site 366394000776 response regulator FixJ; Provisional; Region: fixJ; PRK09390 366394000777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394000778 active site 366394000779 phosphorylation site [posttranslational modification] 366394000780 intermolecular recognition site; other site 366394000781 dimerization interface [polypeptide binding]; other site 366394000782 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394000783 DNA binding residues [nucleotide binding] 366394000784 dimerization interface [polypeptide binding]; other site 366394000785 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 366394000786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394000787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394000788 dimer interface [polypeptide binding]; other site 366394000789 phosphorylation site [posttranslational modification] 366394000790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394000791 ATP binding site [chemical binding]; other site 366394000792 G-X-G motif; other site 366394000793 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 366394000794 MoxR-like ATPases [General function prediction only]; Region: COG0714 366394000795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394000796 ATP binding site [chemical binding]; other site 366394000797 Walker A motif; other site 366394000798 Walker B motif; other site 366394000799 arginine finger; other site 366394000800 Protein of unknown function DUF58; Region: DUF58; pfam01882 366394000801 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 366394000802 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 366394000803 metal ion-dependent adhesion site (MIDAS); other site 366394000804 von Willebrand factor type A domain; Region: VWA_2; pfam13519 366394000805 metal ion-dependent adhesion site (MIDAS); other site 366394000806 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 366394000807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394000808 binding surface 366394000809 TPR motif; other site 366394000810 Oxygen tolerance; Region: BatD; pfam13584 366394000811 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 366394000812 Sulfatase; Region: Sulfatase; pfam00884 366394000813 SPW repeat; Region: SPW; pfam03779 366394000814 SPW repeat; Region: SPW; pfam03779 366394000815 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394000816 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394000817 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394000818 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 366394000819 conserved cys residue [active] 366394000820 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394000821 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394000822 Walker A/P-loop; other site 366394000823 ATP binding site [chemical binding]; other site 366394000824 Q-loop/lid; other site 366394000825 ABC transporter signature motif; other site 366394000826 Walker B; other site 366394000827 D-loop; other site 366394000828 H-loop/switch region; other site 366394000829 TOBE domain; Region: TOBE_2; pfam08402 366394000830 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394000831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000832 dimer interface [polypeptide binding]; other site 366394000833 conserved gate region; other site 366394000834 putative PBP binding loops; other site 366394000835 ABC-ATPase subunit interface; other site 366394000836 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394000837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000838 dimer interface [polypeptide binding]; other site 366394000839 conserved gate region; other site 366394000840 putative PBP binding loops; other site 366394000841 ABC-ATPase subunit interface; other site 366394000842 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394000843 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 366394000844 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394000845 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394000846 DNA binding site [nucleotide binding] 366394000847 domain linker motif; other site 366394000848 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 366394000849 ligand binding site [chemical binding]; other site 366394000850 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394000851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394000852 DNA-binding site [nucleotide binding]; DNA binding site 366394000853 FCD domain; Region: FCD; pfam07729 366394000854 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 366394000855 DctM-like transporters; Region: DctM; pfam06808 366394000856 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 366394000857 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 366394000858 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 366394000859 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394000860 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 366394000861 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394000862 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394000863 TM-ABC transporter signature motif; other site 366394000864 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394000865 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394000866 Walker A/P-loop; other site 366394000867 ATP binding site [chemical binding]; other site 366394000868 Q-loop/lid; other site 366394000869 ABC transporter signature motif; other site 366394000870 Walker B; other site 366394000871 D-loop; other site 366394000872 H-loop/switch region; other site 366394000873 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394000874 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394000875 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 366394000876 ligand binding site [chemical binding]; other site 366394000877 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394000878 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394000879 TM-ABC transporter signature motif; other site 366394000880 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 366394000881 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 366394000882 DAK2 domain; Region: Dak2; pfam02734 366394000883 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 366394000884 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 366394000885 DNA binding residues [nucleotide binding] 366394000886 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 366394000887 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 366394000888 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 366394000889 DAK2 domain; Region: Dak2; cl03685 366394000890 Transposase domain (DUF772); Region: DUF772; pfam05598 366394000891 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394000892 cyclase homology domain; Region: CHD; cd07302 366394000893 nucleotidyl binding site; other site 366394000894 metal binding site [ion binding]; metal-binding site 366394000895 dimer interface [polypeptide binding]; other site 366394000896 Predicted integral membrane protein [Function unknown]; Region: COG5616 366394000897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394000898 binding surface 366394000899 TPR motif; other site 366394000900 TPR repeat; Region: TPR_11; pfam13414 366394000901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394000902 TPR motif; other site 366394000903 Tetratricopeptide repeat; Region: TPR_16; pfam13432 366394000904 binding surface 366394000905 N-acetylneuraminate lyase; Provisional; Region: PRK04147 366394000906 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 366394000907 inhibitor site; inhibition site 366394000908 active site 366394000909 dimer interface [polypeptide binding]; other site 366394000910 catalytic residue [active] 366394000911 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 366394000912 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 366394000913 inhibitor site; inhibition site 366394000914 active site 366394000915 dimer interface [polypeptide binding]; other site 366394000916 catalytic residue [active] 366394000917 DctM-like transporters; Region: DctM; pfam06808 366394000918 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 366394000919 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 366394000920 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 366394000921 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 366394000922 transcriptional regulator NanR; Provisional; Region: PRK03837 366394000923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394000924 DNA-binding site [nucleotide binding]; DNA binding site 366394000925 FCD domain; Region: FCD; pfam07729 366394000926 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 366394000927 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 366394000928 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 366394000929 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 366394000930 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 366394000931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394000932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394000933 DNA binding site [nucleotide binding] 366394000934 domain linker motif; other site 366394000935 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 366394000936 putative dimerization interface [polypeptide binding]; other site 366394000937 putative ligand binding site [chemical binding]; other site 366394000938 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 366394000939 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 366394000940 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 366394000941 active site 366394000942 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 366394000943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394000944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394000945 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394000946 dimerization interface [polypeptide binding]; other site 366394000947 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 366394000948 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 366394000949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000950 ABC-ATPase subunit interface; other site 366394000951 putative PBP binding loops; other site 366394000952 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394000953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394000954 dimer interface [polypeptide binding]; other site 366394000955 conserved gate region; other site 366394000956 putative PBP binding loops; other site 366394000957 ABC-ATPase subunit interface; other site 366394000958 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394000959 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 366394000960 Walker A/P-loop; other site 366394000961 ATP binding site [chemical binding]; other site 366394000962 Q-loop/lid; other site 366394000963 ABC transporter signature motif; other site 366394000964 Walker B; other site 366394000965 D-loop; other site 366394000966 H-loop/switch region; other site 366394000967 TOBE domain; Region: TOBE_2; pfam08402 366394000968 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 366394000969 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 366394000970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 366394000971 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 366394000972 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 366394000973 hypothetical protein; Provisional; Region: PRK07483 366394000974 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 366394000975 inhibitor-cofactor binding pocket; inhibition site 366394000976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394000977 catalytic residue [active] 366394000978 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 366394000979 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 366394000980 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 366394000981 putative active site [active] 366394000982 Uncharacterized conserved protein [Function unknown]; Region: COG3246 366394000983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394000984 Major Facilitator Superfamily; Region: MFS_1; pfam07690 366394000985 putative substrate translocation pore; other site 366394000986 OsmC-like protein; Region: OsmC; cl00767 366394000987 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 366394000988 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 366394000989 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 366394000990 substrate binding site [chemical binding]; other site 366394000991 Protein of unknown function (DUF521); Region: DUF521; pfam04412 366394000992 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 366394000993 substrate binding site [chemical binding]; other site 366394000994 ligand binding site [chemical binding]; other site 366394000995 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 366394000996 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 366394000997 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 366394000998 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 366394000999 NAD binding site [chemical binding]; other site 366394001000 hydroxyglutarate oxidase; Provisional; Region: PRK11728 366394001001 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 366394001002 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 366394001003 Walker A/P-loop; other site 366394001004 ATP binding site [chemical binding]; other site 366394001005 Q-loop/lid; other site 366394001006 ABC transporter signature motif; other site 366394001007 Walker B; other site 366394001008 D-loop; other site 366394001009 H-loop/switch region; other site 366394001010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001011 dimer interface [polypeptide binding]; other site 366394001012 conserved gate region; other site 366394001013 putative PBP binding loops; other site 366394001014 ABC-ATPase subunit interface; other site 366394001015 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 366394001016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001017 dimer interface [polypeptide binding]; other site 366394001018 conserved gate region; other site 366394001019 putative PBP binding loops; other site 366394001020 ABC-ATPase subunit interface; other site 366394001021 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 366394001022 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394001023 substrate binding pocket [chemical binding]; other site 366394001024 membrane-bound complex binding site; other site 366394001025 hinge residues; other site 366394001026 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 366394001027 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 366394001028 dimer interface [polypeptide binding]; other site 366394001029 NADP binding site [chemical binding]; other site 366394001030 catalytic residues [active] 366394001031 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 366394001032 Uncharacterized conserved protein [Function unknown]; Region: COG3339 366394001033 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 366394001034 active site 366394001035 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 366394001036 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 366394001037 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 366394001038 inhibitor site; inhibition site 366394001039 active site 366394001040 dimer interface [polypeptide binding]; other site 366394001041 catalytic residue [active] 366394001042 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394001043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394001044 DNA-binding site [nucleotide binding]; DNA binding site 366394001045 FCD domain; Region: FCD; pfam07729 366394001046 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394001047 cyclase homology domain; Region: CHD; cd07302 366394001048 nucleotidyl binding site; other site 366394001049 metal binding site [ion binding]; metal-binding site 366394001050 dimer interface [polypeptide binding]; other site 366394001051 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 366394001052 putative hydrophobic ligand binding site [chemical binding]; other site 366394001053 Predicted membrane protein [Function unknown]; Region: COG4420 366394001054 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 366394001055 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 366394001056 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 366394001057 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 366394001058 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 366394001059 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 366394001060 catalytic core [active] 366394001061 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 366394001062 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 366394001063 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394001064 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394001065 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394001066 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 366394001067 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 366394001068 putative NAD(P) binding site [chemical binding]; other site 366394001069 catalytic Zn binding site [ion binding]; other site 366394001070 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394001071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394001072 NAD(P) binding site [chemical binding]; other site 366394001073 active site 366394001074 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 366394001075 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394001076 NAD binding site [chemical binding]; other site 366394001077 homotetramer interface [polypeptide binding]; other site 366394001078 homodimer interface [polypeptide binding]; other site 366394001079 active site 366394001080 substrate binding site [chemical binding]; other site 366394001081 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 366394001082 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394001083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 366394001084 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 366394001085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 366394001086 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 366394001087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 366394001088 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 366394001089 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 366394001090 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394001091 NAD binding site [chemical binding]; other site 366394001092 putative substrate binding site 2 [chemical binding]; other site 366394001093 putative substrate binding site 1 [chemical binding]; other site 366394001094 active site 366394001095 Methyltransferase domain; Region: Methyltransf_23; pfam13489 366394001096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394001097 S-adenosylmethionine binding site [chemical binding]; other site 366394001098 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 366394001099 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 366394001100 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 366394001101 BON domain; Region: BON; pfam04972 366394001102 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 366394001103 Cupin domain; Region: Cupin_2; pfam07883 366394001104 osmolarity response regulator; Provisional; Region: ompR; PRK09468 366394001105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394001106 active site 366394001107 phosphorylation site [posttranslational modification] 366394001108 intermolecular recognition site; other site 366394001109 dimerization interface [polypeptide binding]; other site 366394001110 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394001111 DNA binding site [nucleotide binding] 366394001112 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 366394001113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394001114 dimer interface [polypeptide binding]; other site 366394001115 phosphorylation site [posttranslational modification] 366394001116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394001117 ATP binding site [chemical binding]; other site 366394001118 Mg2+ binding site [ion binding]; other site 366394001119 G-X-G motif; other site 366394001120 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 366394001121 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394001122 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 366394001123 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 366394001124 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 366394001125 potential catalytic triad [active] 366394001126 conserved cys residue [active] 366394001127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394001128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394001129 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 366394001130 putative effector binding pocket; other site 366394001131 putative dimerization interface [polypeptide binding]; other site 366394001132 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 366394001133 classical (c) SDRs; Region: SDR_c; cd05233 366394001134 NAD(P) binding site [chemical binding]; other site 366394001135 active site 366394001136 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 366394001137 active site 1 [active] 366394001138 dimer interface [polypeptide binding]; other site 366394001139 hexamer interface [polypeptide binding]; other site 366394001140 active site 2 [active] 366394001141 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 366394001142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 366394001143 FeS/SAM binding site; other site 366394001144 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 366394001145 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 366394001146 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 366394001147 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 366394001148 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 366394001149 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394001150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394001151 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 366394001152 putative dimerization interface [polypeptide binding]; other site 366394001153 fructose-1,6-bisphosphatase family protein; Region: PLN02628 366394001154 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 366394001155 AMP binding site [chemical binding]; other site 366394001156 metal binding site [ion binding]; metal-binding site 366394001157 active site 366394001158 phosphoribulokinase; Provisional; Region: PRK15453 366394001159 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 366394001160 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 366394001161 TPP-binding site [chemical binding]; other site 366394001162 dimer interface [polypeptide binding]; other site 366394001163 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 366394001164 PYR/PP interface [polypeptide binding]; other site 366394001165 dimer interface [polypeptide binding]; other site 366394001166 TPP binding site [chemical binding]; other site 366394001167 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 366394001168 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 366394001169 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 366394001170 intersubunit interface [polypeptide binding]; other site 366394001171 active site 366394001172 zinc binding site [ion binding]; other site 366394001173 Na+ binding site [ion binding]; other site 366394001174 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 366394001175 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 366394001176 homodimer interface [polypeptide binding]; other site 366394001177 active site 366394001178 heterodimer interface [polypeptide binding]; other site 366394001179 catalytic residue [active] 366394001180 metal binding site [ion binding]; metal-binding site 366394001181 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 366394001182 multimerization interface [polypeptide binding]; other site 366394001183 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 366394001184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394001185 Walker A motif; other site 366394001186 ATP binding site [chemical binding]; other site 366394001187 Walker B motif; other site 366394001188 arginine finger; other site 366394001189 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 366394001190 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 366394001191 substrate binding site [chemical binding]; other site 366394001192 hexamer interface [polypeptide binding]; other site 366394001193 metal binding site [ion binding]; metal-binding site 366394001194 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 366394001195 putative catalytic residue [active] 366394001196 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394001197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394001198 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394001199 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 366394001200 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 366394001201 alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861 366394001202 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 366394001203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394001204 Walker A/P-loop; other site 366394001205 ATP binding site [chemical binding]; other site 366394001206 Q-loop/lid; other site 366394001207 ABC transporter signature motif; other site 366394001208 Walker B; other site 366394001209 D-loop; other site 366394001210 H-loop/switch region; other site 366394001211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394001212 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 366394001213 Walker A/P-loop; other site 366394001214 ATP binding site [chemical binding]; other site 366394001215 Q-loop/lid; other site 366394001216 ABC transporter signature motif; other site 366394001217 Walker B; other site 366394001218 D-loop; other site 366394001219 H-loop/switch region; other site 366394001220 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 366394001221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001222 dimer interface [polypeptide binding]; other site 366394001223 conserved gate region; other site 366394001224 putative PBP binding loops; other site 366394001225 ABC-ATPase subunit interface; other site 366394001226 NMT1/THI5 like; Region: NMT1; pfam09084 366394001227 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 366394001228 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 366394001229 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 366394001230 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 366394001231 structural tetrad; other site 366394001232 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 366394001233 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 366394001234 ligand binding site [chemical binding]; other site 366394001235 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 366394001236 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 366394001237 active site residue [active] 366394001238 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 366394001239 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394001240 substrate binding pocket [chemical binding]; other site 366394001241 membrane-bound complex binding site; other site 366394001242 hinge residues; other site 366394001243 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 366394001244 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 366394001245 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 366394001246 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 366394001247 Trp docking motif [polypeptide binding]; other site 366394001248 dimer interface [polypeptide binding]; other site 366394001249 active site 366394001250 small subunit binding site [polypeptide binding]; other site 366394001251 Cytochrome c2 [Energy production and conversion]; Region: COG3474 366394001252 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 366394001253 S-formylglutathione hydrolase; Region: PLN02442 366394001254 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 366394001255 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 366394001256 substrate binding site [chemical binding]; other site 366394001257 catalytic Zn binding site [ion binding]; other site 366394001258 NAD binding site [chemical binding]; other site 366394001259 structural Zn binding site [ion binding]; other site 366394001260 dimer interface [polypeptide binding]; other site 366394001261 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 366394001262 Predicted secreted protein [Function unknown]; Region: COG5501 366394001263 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 366394001264 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 366394001265 PAS fold; Region: PAS_7; pfam12860 366394001266 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 366394001267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394001268 dimer interface [polypeptide binding]; other site 366394001269 phosphorylation site [posttranslational modification] 366394001270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394001271 ATP binding site [chemical binding]; other site 366394001272 Mg2+ binding site [ion binding]; other site 366394001273 G-X-G motif; other site 366394001274 Response regulator receiver domain; Region: Response_reg; pfam00072 366394001275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394001276 active site 366394001277 phosphorylation site [posttranslational modification] 366394001278 intermolecular recognition site; other site 366394001279 dimerization interface [polypeptide binding]; other site 366394001280 Uncharacterized conserved protein [Function unknown]; Region: COG3287 366394001281 FIST N domain; Region: FIST; pfam08495 366394001282 FIST C domain; Region: FIST_C; pfam10442 366394001283 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394001284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394001285 active site 366394001286 phosphorylation site [posttranslational modification] 366394001287 intermolecular recognition site; other site 366394001288 dimerization interface [polypeptide binding]; other site 366394001289 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394001290 DNA binding residues [nucleotide binding] 366394001291 dimerization interface [polypeptide binding]; other site 366394001292 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 366394001293 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 366394001294 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 366394001295 active site 366394001296 catalytic residues [active] 366394001297 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 366394001298 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 366394001299 active site 366394001300 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 366394001301 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 366394001302 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 366394001303 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 366394001304 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394001305 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394001306 Walker A/P-loop; other site 366394001307 ATP binding site [chemical binding]; other site 366394001308 Q-loop/lid; other site 366394001309 ABC transporter signature motif; other site 366394001310 Walker B; other site 366394001311 D-loop; other site 366394001312 H-loop/switch region; other site 366394001313 TOBE domain; Region: TOBE_2; pfam08402 366394001314 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 366394001315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001316 dimer interface [polypeptide binding]; other site 366394001317 conserved gate region; other site 366394001318 putative PBP binding loops; other site 366394001319 ABC-ATPase subunit interface; other site 366394001320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001321 dimer interface [polypeptide binding]; other site 366394001322 conserved gate region; other site 366394001323 putative PBP binding loops; other site 366394001324 ABC-ATPase subunit interface; other site 366394001325 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394001326 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394001327 DNA binding site [nucleotide binding] 366394001328 domain linker motif; other site 366394001329 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 366394001330 putative dimerization interface [polypeptide binding]; other site 366394001331 putative ligand binding site [chemical binding]; other site 366394001332 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 366394001333 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 366394001334 PhoU domain; Region: PhoU; pfam01895 366394001335 PhoU domain; Region: PhoU; pfam01895 366394001336 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 366394001337 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 366394001338 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 366394001339 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 366394001340 active site 366394001341 catalytic residues [active] 366394001342 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 366394001343 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 366394001344 active site 366394001345 dimerization interface [polypeptide binding]; other site 366394001346 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 366394001347 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 366394001348 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 366394001349 Transmembrane secretion effector; Region: MFS_3; pfam05977 366394001350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394001351 putative substrate translocation pore; other site 366394001352 Predicted membrane protein [Function unknown]; Region: COG2259 366394001353 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 366394001354 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 366394001355 active site 366394001356 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 366394001357 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 366394001358 catalytic triad [active] 366394001359 dimer interface [polypeptide binding]; other site 366394001360 Isochorismatase family; Region: Isochorismatase; pfam00857 366394001361 conserved cis-peptide bond; other site 366394001362 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394001363 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 366394001364 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394001365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394001366 Helix-turn-helix domain; Region: HTH_18; pfam12833 366394001367 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394001368 Helix-turn-helix domain; Region: HTH_18; pfam12833 366394001369 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394001370 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 366394001371 dimanganese center [ion binding]; other site 366394001372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 366394001373 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394001374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394001375 DNA-binding site [nucleotide binding]; DNA binding site 366394001376 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 366394001377 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 366394001378 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 366394001379 active site 366394001380 NAD binding site [chemical binding]; other site 366394001381 metal binding site [ion binding]; metal-binding site 366394001382 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 366394001383 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 366394001384 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 366394001385 BNR repeat-like domain; Region: BNR_2; pfam13088 366394001386 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394001387 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 366394001388 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394001389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001390 dimer interface [polypeptide binding]; other site 366394001391 conserved gate region; other site 366394001392 putative PBP binding loops; other site 366394001393 ABC-ATPase subunit interface; other site 366394001394 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 366394001395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001396 dimer interface [polypeptide binding]; other site 366394001397 conserved gate region; other site 366394001398 putative PBP binding loops; other site 366394001399 ABC-ATPase subunit interface; other site 366394001400 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 366394001401 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394001402 Walker A/P-loop; other site 366394001403 ATP binding site [chemical binding]; other site 366394001404 Q-loop/lid; other site 366394001405 ABC transporter signature motif; other site 366394001406 Walker B; other site 366394001407 D-loop; other site 366394001408 H-loop/switch region; other site 366394001409 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 366394001410 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394001411 Walker A/P-loop; other site 366394001412 ATP binding site [chemical binding]; other site 366394001413 Q-loop/lid; other site 366394001414 ABC transporter signature motif; other site 366394001415 Walker B; other site 366394001416 D-loop; other site 366394001417 H-loop/switch region; other site 366394001418 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394001419 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 366394001420 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 366394001421 inhibitor site; inhibition site 366394001422 active site 366394001423 dimer interface [polypeptide binding]; other site 366394001424 catalytic residue [active] 366394001425 hypothetical protein; Provisional; Region: PRK07588 366394001426 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 366394001427 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 366394001428 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 366394001429 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394001430 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 366394001431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394001432 putative substrate translocation pore; other site 366394001433 cyclase homology domain; Region: CHD; cd07302 366394001434 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394001435 nucleotidyl binding site; other site 366394001436 metal binding site [ion binding]; metal-binding site 366394001437 dimer interface [polypeptide binding]; other site 366394001438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394001439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394001440 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 366394001441 Predicted membrane protein [Function unknown]; Region: COG4329 366394001442 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 366394001443 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 366394001444 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 366394001445 active site 366394001446 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 366394001447 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 366394001448 Flavoprotein; Region: Flavoprotein; pfam02441 366394001449 xanthine permease; Region: pbuX; TIGR03173 366394001450 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 366394001451 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 366394001452 P-loop, Walker A motif; other site 366394001453 Base recognition motif; other site 366394001454 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 366394001455 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 366394001456 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 366394001457 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 366394001458 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 366394001459 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394001460 catalytic loop [active] 366394001461 iron binding site [ion binding]; other site 366394001462 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 366394001463 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 366394001464 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 366394001465 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394001466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 366394001467 DNA-binding site [nucleotide binding]; DNA binding site 366394001468 FCD domain; Region: FCD; pfam07729 366394001469 cytosine deaminase; Provisional; Region: PRK05985 366394001470 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 366394001471 active site 366394001472 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 366394001473 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 366394001474 putative ligand binding site [chemical binding]; other site 366394001475 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394001476 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 366394001477 TM-ABC transporter signature motif; other site 366394001478 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394001479 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 366394001480 TM-ABC transporter signature motif; other site 366394001481 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 366394001482 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394001483 Walker A/P-loop; other site 366394001484 ATP binding site [chemical binding]; other site 366394001485 Q-loop/lid; other site 366394001486 ABC transporter signature motif; other site 366394001487 Walker B; other site 366394001488 D-loop; other site 366394001489 H-loop/switch region; other site 366394001490 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394001491 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394001492 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394001493 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 366394001494 putative dimerization interface [polypeptide binding]; other site 366394001495 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 366394001496 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 366394001497 substrate binding site [chemical binding]; other site 366394001498 ATP binding site [chemical binding]; other site 366394001499 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 366394001500 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 366394001501 homodimer interface [polypeptide binding]; other site 366394001502 substrate-cofactor binding pocket; other site 366394001503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394001504 catalytic residue [active] 366394001505 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394001506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001507 dimer interface [polypeptide binding]; other site 366394001508 conserved gate region; other site 366394001509 putative PBP binding loops; other site 366394001510 ABC-ATPase subunit interface; other site 366394001511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001512 dimer interface [polypeptide binding]; other site 366394001513 conserved gate region; other site 366394001514 putative PBP binding loops; other site 366394001515 ABC-ATPase subunit interface; other site 366394001516 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394001517 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394001518 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 366394001519 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 366394001520 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 366394001521 putative active site [active] 366394001522 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 366394001523 active site 366394001524 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 366394001525 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394001526 putative ADP-binding pocket [chemical binding]; other site 366394001527 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 366394001528 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 366394001529 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 366394001530 hypothetical protein; Validated; Region: PRK08245 366394001531 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 366394001532 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 366394001533 putative ligand binding site [chemical binding]; other site 366394001534 NAD binding site [chemical binding]; other site 366394001535 catalytic site [active] 366394001536 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 366394001537 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394001538 Walker A/P-loop; other site 366394001539 ATP binding site [chemical binding]; other site 366394001540 Q-loop/lid; other site 366394001541 ABC transporter signature motif; other site 366394001542 Walker B; other site 366394001543 D-loop; other site 366394001544 H-loop/switch region; other site 366394001545 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 366394001546 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394001547 Walker A/P-loop; other site 366394001548 ATP binding site [chemical binding]; other site 366394001549 Q-loop/lid; other site 366394001550 ABC transporter signature motif; other site 366394001551 Walker B; other site 366394001552 D-loop; other site 366394001553 H-loop/switch region; other site 366394001554 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394001555 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 366394001556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001557 dimer interface [polypeptide binding]; other site 366394001558 conserved gate region; other site 366394001559 putative PBP binding loops; other site 366394001560 ABC-ATPase subunit interface; other site 366394001561 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394001562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001563 dimer interface [polypeptide binding]; other site 366394001564 conserved gate region; other site 366394001565 putative PBP binding loops; other site 366394001566 ABC-ATPase subunit interface; other site 366394001567 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394001568 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 366394001569 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 366394001570 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 366394001571 inhibitor site; inhibition site 366394001572 active site 366394001573 dimer interface [polypeptide binding]; other site 366394001574 catalytic residue [active] 366394001575 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394001576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394001577 DNA-binding site [nucleotide binding]; DNA binding site 366394001578 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 366394001579 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394001580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394001581 DNA-binding site [nucleotide binding]; DNA binding site 366394001582 FCD domain; Region: FCD; pfam07729 366394001583 SnoaL-like domain; Region: SnoaL_2; pfam12680 366394001584 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 366394001585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 366394001586 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 366394001587 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 366394001588 putative NAD(P) binding site [chemical binding]; other site 366394001589 catalytic Zn binding site [ion binding]; other site 366394001590 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 366394001591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394001592 Walker A motif; other site 366394001593 ATP binding site [chemical binding]; other site 366394001594 Walker B motif; other site 366394001595 arginine finger; other site 366394001596 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 366394001597 Predicted dehydrogenase [General function prediction only]; Region: COG0579 366394001598 hydroxyglutarate oxidase; Provisional; Region: PRK11728 366394001599 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 366394001600 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 366394001601 trehalose synthase; Region: treS_nterm; TIGR02456 366394001602 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 366394001603 active site 366394001604 catalytic site [active] 366394001605 Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751 366394001606 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 366394001607 FAD binding domain; Region: FAD_binding_4; pfam01565 366394001608 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 366394001609 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 366394001610 thiamine pyrophosphate protein; Provisional; Region: PRK08273 366394001611 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 366394001612 PYR/PP interface [polypeptide binding]; other site 366394001613 dimer interface [polypeptide binding]; other site 366394001614 tetramer interface [polypeptide binding]; other site 366394001615 TPP binding site [chemical binding]; other site 366394001616 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 366394001617 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 366394001618 TPP-binding site [chemical binding]; other site 366394001619 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 366394001620 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 366394001621 putative active site [active] 366394001622 catalytic site [active] 366394001623 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 366394001624 putative active site [active] 366394001625 catalytic site [active] 366394001626 Predicted integral membrane protein [Function unknown]; Region: COG0392 366394001627 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 366394001628 putative catalytic site [active] 366394001629 putative metal binding site [ion binding]; other site 366394001630 putative phosphate binding site [ion binding]; other site 366394001631 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 366394001632 dinuclear metal binding motif [ion binding]; other site 366394001633 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 366394001634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394001635 S-adenosylmethionine binding site [chemical binding]; other site 366394001636 Erythromycin esterase; Region: Erythro_esteras; pfam05139 366394001637 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 366394001638 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 366394001639 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 366394001640 active site 366394001641 metal binding site [ion binding]; metal-binding site 366394001642 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 366394001643 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 366394001644 NAD binding site [chemical binding]; other site 366394001645 catalytic Zn binding site [ion binding]; other site 366394001646 structural Zn binding site [ion binding]; other site 366394001647 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 366394001648 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 366394001649 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 366394001650 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 366394001651 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394001652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394001653 active site 366394001654 phosphorylation site [posttranslational modification] 366394001655 intermolecular recognition site; other site 366394001656 dimerization interface [polypeptide binding]; other site 366394001657 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394001658 DNA binding residues [nucleotide binding] 366394001659 dimerization interface [polypeptide binding]; other site 366394001660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 366394001661 Histidine kinase; Region: HisKA_3; pfam07730 366394001662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394001663 ATP binding site [chemical binding]; other site 366394001664 Mg2+ binding site [ion binding]; other site 366394001665 G-X-G motif; other site 366394001666 short chain dehydrogenase; Provisional; Region: PRK06139 366394001667 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 366394001668 putative NAD(P) binding site [chemical binding]; other site 366394001669 active site 366394001670 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 366394001671 short chain dehydrogenase; Provisional; Region: PRK06701 366394001672 NAD binding site [chemical binding]; other site 366394001673 metal binding site [ion binding]; metal-binding site 366394001674 active site 366394001675 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394001676 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 366394001677 putative ligand binding site [chemical binding]; other site 366394001678 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 366394001679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394001680 putative substrate translocation pore; other site 366394001681 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 366394001682 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 366394001683 Sulfate transporter family; Region: Sulfate_transp; pfam00916 366394001684 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 366394001685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394001686 putative substrate translocation pore; other site 366394001687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 366394001688 Uncharacterized conserved protein [Function unknown]; Region: COG3360 366394001689 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 366394001690 active site 366394001691 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394001692 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 366394001693 Isochorismatase family; Region: Isochorismatase; pfam00857 366394001694 catalytic triad [active] 366394001695 dimer interface [polypeptide binding]; other site 366394001696 conserved cis-peptide bond; other site 366394001697 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 366394001698 Zn binding site [ion binding]; other site 366394001699 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 366394001700 Zn binding site [ion binding]; other site 366394001701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394001702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394001703 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 366394001704 putative effector binding pocket; other site 366394001705 dimerization interface [polypeptide binding]; other site 366394001706 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 366394001707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394001708 S-adenosylmethionine binding site [chemical binding]; other site 366394001709 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 366394001710 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 366394001711 Walker A/P-loop; other site 366394001712 ATP binding site [chemical binding]; other site 366394001713 Q-loop/lid; other site 366394001714 ABC transporter signature motif; other site 366394001715 Walker B; other site 366394001716 D-loop; other site 366394001717 H-loop/switch region; other site 366394001718 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 366394001719 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 366394001720 ABC-ATPase subunit interface; other site 366394001721 dimer interface [polypeptide binding]; other site 366394001722 putative PBP binding regions; other site 366394001723 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 366394001724 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 366394001725 putative ligand binding residues [chemical binding]; other site 366394001726 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 366394001727 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 366394001728 conserved cys residue [active] 366394001729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394001730 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 366394001731 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 366394001732 elongation factor G; Reviewed; Region: PRK12740 366394001733 G1 box; other site 366394001734 GTP/Mg2+ binding site [chemical binding]; other site 366394001735 Switch I region; other site 366394001736 G3 box; other site 366394001737 Switch II region; other site 366394001738 G4 box; other site 366394001739 G5 box; other site 366394001740 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 366394001741 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 366394001742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394001743 DNA-binding site [nucleotide binding]; DNA binding site 366394001744 UTRA domain; Region: UTRA; pfam07702 366394001745 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 366394001746 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 366394001747 P-loop; other site 366394001748 Magnesium ion binding site [ion binding]; other site 366394001749 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 366394001750 Magnesium ion binding site [ion binding]; other site 366394001751 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 366394001752 ParB-like nuclease domain; Region: ParB; smart00470 366394001753 replication initiation protein RepC; Provisional; Region: PRK13824 366394001754 Replication protein C N-terminal domain; Region: RP-C; pfam03428 366394001755 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 366394001756 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 366394001757 HTH DNA binding domain; Region: HTH_13; pfam11972 366394001758 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 366394001759 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 366394001760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394001761 DNA-binding site [nucleotide binding]; DNA binding site 366394001762 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394001763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394001764 homodimer interface [polypeptide binding]; other site 366394001765 catalytic residue [active] 366394001766 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 366394001767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 366394001768 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 366394001769 DNA binding residues [nucleotide binding] 366394001770 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 366394001771 Uncharacterized conserved protein [Function unknown]; Region: COG2128 366394001772 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 366394001773 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 366394001774 DNA binding residues [nucleotide binding] 366394001775 putative dimer interface [polypeptide binding]; other site 366394001776 hypothetical protein; Provisional; Region: PRK09266 366394001777 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 366394001778 substrate-cofactor binding pocket; other site 366394001779 homodimer interface [polypeptide binding]; other site 366394001780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394001781 catalytic residue [active] 366394001782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 366394001783 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 366394001784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 366394001785 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 366394001786 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 366394001787 RNA binding surface [nucleotide binding]; other site 366394001788 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 366394001789 active site 366394001790 5-oxoprolinase; Region: PLN02666 366394001791 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 366394001792 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 366394001793 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 366394001794 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 366394001795 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394001796 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394001797 putative DNA binding site [nucleotide binding]; other site 366394001798 putative Zn2+ binding site [ion binding]; other site 366394001799 AsnC family; Region: AsnC_trans_reg; pfam01037 366394001800 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 366394001801 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 366394001802 tetramer interface [polypeptide binding]; other site 366394001803 TPP-binding site [chemical binding]; other site 366394001804 heterodimer interface [polypeptide binding]; other site 366394001805 phosphorylation loop region [posttranslational modification] 366394001806 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 366394001807 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 366394001808 alpha subunit interface [polypeptide binding]; other site 366394001809 TPP binding site [chemical binding]; other site 366394001810 heterodimer interface [polypeptide binding]; other site 366394001811 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 366394001812 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 366394001813 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 366394001814 E3 interaction surface; other site 366394001815 lipoyl attachment site [posttranslational modification]; other site 366394001816 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 366394001817 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 366394001818 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 366394001819 putative ligand binding site [chemical binding]; other site 366394001820 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394001821 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 366394001822 Walker A/P-loop; other site 366394001823 ATP binding site [chemical binding]; other site 366394001824 Q-loop/lid; other site 366394001825 ABC transporter signature motif; other site 366394001826 Walker B; other site 366394001827 D-loop; other site 366394001828 H-loop/switch region; other site 366394001829 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394001830 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394001831 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394001832 TM-ABC transporter signature motif; other site 366394001833 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394001834 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394001835 TM-ABC transporter signature motif; other site 366394001836 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394001837 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394001838 DNA binding site [nucleotide binding] 366394001839 domain linker motif; other site 366394001840 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 366394001841 dimerization interface [polypeptide binding]; other site 366394001842 ligand binding site [chemical binding]; other site 366394001843 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394001844 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394001845 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394001846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394001847 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394001848 NAD(P) binding site [chemical binding]; other site 366394001849 active site 366394001850 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 366394001851 putative active site [active] 366394001852 redox center [active] 366394001853 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 366394001854 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 366394001855 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 366394001856 active site 366394001857 DNA binding site [nucleotide binding] 366394001858 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 366394001859 DNA binding site [nucleotide binding] 366394001860 hydroperoxidase II; Provisional; Region: katE; PRK11249 366394001861 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 366394001862 tetramer interface [polypeptide binding]; other site 366394001863 heme binding pocket [chemical binding]; other site 366394001864 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 366394001865 domain interactions; other site 366394001866 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 366394001867 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 366394001868 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394001869 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 366394001870 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 366394001871 putative N-terminal domain interface [polypeptide binding]; other site 366394001872 putative dimer interface [polypeptide binding]; other site 366394001873 putative substrate binding pocket (H-site) [chemical binding]; other site 366394001874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394001875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394001876 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 366394001877 putative effector binding pocket; other site 366394001878 putative dimerization interface [polypeptide binding]; other site 366394001879 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 366394001880 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 366394001881 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 366394001882 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 366394001883 ring oligomerisation interface [polypeptide binding]; other site 366394001884 ATP/Mg binding site [chemical binding]; other site 366394001885 stacking interactions; other site 366394001886 hinge regions; other site 366394001887 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394001888 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394001889 Walker A/P-loop; other site 366394001890 ATP binding site [chemical binding]; other site 366394001891 Q-loop/lid; other site 366394001892 ABC transporter signature motif; other site 366394001893 Walker B; other site 366394001894 D-loop; other site 366394001895 H-loop/switch region; other site 366394001896 TOBE domain; Region: TOBE_2; pfam08402 366394001897 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 366394001898 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 366394001899 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 366394001900 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 366394001901 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394001902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001903 dimer interface [polypeptide binding]; other site 366394001904 conserved gate region; other site 366394001905 putative PBP binding loops; other site 366394001906 ABC-ATPase subunit interface; other site 366394001907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 366394001908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001909 putative PBP binding loops; other site 366394001910 ABC-ATPase subunit interface; other site 366394001911 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394001912 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394001913 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394001914 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 366394001915 putative dimerization interface [polypeptide binding]; other site 366394001916 putative ligand binding site [chemical binding]; other site 366394001917 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 366394001918 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 366394001919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394001920 alpha-galactosidase; Provisional; Region: PRK15076 366394001921 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 366394001922 NAD binding site [chemical binding]; other site 366394001923 sugar binding site [chemical binding]; other site 366394001924 divalent metal binding site [ion binding]; other site 366394001925 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 366394001926 dimer interface [polypeptide binding]; other site 366394001927 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 366394001928 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 366394001929 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394001930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001931 dimer interface [polypeptide binding]; other site 366394001932 conserved gate region; other site 366394001933 putative PBP binding loops; other site 366394001934 ABC-ATPase subunit interface; other site 366394001935 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 366394001936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394001937 dimer interface [polypeptide binding]; other site 366394001938 conserved gate region; other site 366394001939 putative PBP binding loops; other site 366394001940 ABC-ATPase subunit interface; other site 366394001941 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 366394001942 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394001943 Walker A/P-loop; other site 366394001944 ATP binding site [chemical binding]; other site 366394001945 Q-loop/lid; other site 366394001946 ABC transporter signature motif; other site 366394001947 Walker B; other site 366394001948 D-loop; other site 366394001949 H-loop/switch region; other site 366394001950 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394001951 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394001952 Walker A/P-loop; other site 366394001953 ATP binding site [chemical binding]; other site 366394001954 Q-loop/lid; other site 366394001955 ABC transporter signature motif; other site 366394001956 Walker B; other site 366394001957 D-loop; other site 366394001958 H-loop/switch region; other site 366394001959 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394001960 alpha-galactosidase; Provisional; Region: PRK15076 366394001961 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 366394001962 NAD binding site [chemical binding]; other site 366394001963 sugar binding site [chemical binding]; other site 366394001964 divalent metal binding site [ion binding]; other site 366394001965 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 366394001966 dimer interface [polypeptide binding]; other site 366394001967 Protein of unknown function (DUF992); Region: DUF992; pfam06186 366394001968 PaaX-like protein; Region: PaaX; pfam07848 366394001969 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 366394001970 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 366394001971 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 366394001972 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 366394001973 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 366394001974 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 366394001975 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 366394001976 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 366394001977 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 366394001978 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 366394001979 FAD binding pocket [chemical binding]; other site 366394001980 FAD binding motif [chemical binding]; other site 366394001981 phosphate binding motif [ion binding]; other site 366394001982 beta-alpha-beta structure motif; other site 366394001983 NAD(p) ribose binding residues [chemical binding]; other site 366394001984 NAD binding pocket [chemical binding]; other site 366394001985 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 366394001986 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394001987 catalytic loop [active] 366394001988 iron binding site [ion binding]; other site 366394001989 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 366394001990 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 366394001991 substrate binding site [chemical binding]; other site 366394001992 dimer interface [polypeptide binding]; other site 366394001993 NADP binding site [chemical binding]; other site 366394001994 catalytic residues [active] 366394001995 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 366394001996 substrate binding site [chemical binding]; other site 366394001997 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 366394001998 enoyl-CoA hydratase; Provisional; Region: PRK08140 366394001999 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 366394002000 substrate binding site [chemical binding]; other site 366394002001 oxyanion hole (OAH) forming residues; other site 366394002002 trimer interface [polypeptide binding]; other site 366394002003 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 366394002004 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 366394002005 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 366394002006 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 366394002007 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 366394002008 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 366394002009 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 366394002010 dimer interface [polypeptide binding]; other site 366394002011 active site 366394002012 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 366394002013 catalytic residues [active] 366394002014 substrate binding site [chemical binding]; other site 366394002015 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 366394002016 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 366394002017 NAD(P) binding pocket [chemical binding]; other site 366394002018 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394002019 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394002020 DNA binding site [nucleotide binding] 366394002021 domain linker motif; other site 366394002022 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 366394002023 dimerization interface [polypeptide binding]; other site 366394002024 ligand binding site [chemical binding]; other site 366394002025 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394002026 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394002027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394002028 dimer interface [polypeptide binding]; other site 366394002029 conserved gate region; other site 366394002030 putative PBP binding loops; other site 366394002031 ABC-ATPase subunit interface; other site 366394002032 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394002033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394002034 dimer interface [polypeptide binding]; other site 366394002035 conserved gate region; other site 366394002036 putative PBP binding loops; other site 366394002037 ABC-ATPase subunit interface; other site 366394002038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 366394002039 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 366394002040 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394002041 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394002042 Walker A/P-loop; other site 366394002043 ATP binding site [chemical binding]; other site 366394002044 Q-loop/lid; other site 366394002045 ABC transporter signature motif; other site 366394002046 Walker B; other site 366394002047 D-loop; other site 366394002048 H-loop/switch region; other site 366394002049 TOBE domain; Region: TOBE_2; pfam08402 366394002050 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 366394002051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394002052 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394002053 dimerization interface [polypeptide binding]; other site 366394002054 Lysine efflux permease [General function prediction only]; Region: COG1279 366394002055 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 366394002056 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 366394002057 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 366394002058 inhibitor site; inhibition site 366394002059 active site 366394002060 dimer interface [polypeptide binding]; other site 366394002061 catalytic residue [active] 366394002062 Cupin; Region: Cupin_6; pfam12852 366394002063 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394002064 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 366394002065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394002066 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 366394002067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394002068 putative substrate translocation pore; other site 366394002069 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 366394002070 thiamine phosphate binding site [chemical binding]; other site 366394002071 active site 366394002072 pyrophosphate binding site [ion binding]; other site 366394002073 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 366394002074 ThiS interaction site; other site 366394002075 putative active site [active] 366394002076 tetramer interface [polypeptide binding]; other site 366394002077 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 366394002078 thiS-thiF/thiG interaction site; other site 366394002079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 366394002080 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 366394002081 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 366394002082 ThiC-associated domain; Region: ThiC-associated; pfam13667 366394002083 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 366394002084 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 366394002085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394002086 active site 366394002087 phosphorylation site [posttranslational modification] 366394002088 intermolecular recognition site; other site 366394002089 dimerization interface [polypeptide binding]; other site 366394002090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394002091 Walker A motif; other site 366394002092 ATP binding site [chemical binding]; other site 366394002093 Walker B motif; other site 366394002094 arginine finger; other site 366394002095 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 366394002096 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 366394002097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394002098 dimer interface [polypeptide binding]; other site 366394002099 phosphorylation site [posttranslational modification] 366394002100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394002101 ATP binding site [chemical binding]; other site 366394002102 Mg2+ binding site [ion binding]; other site 366394002103 G-X-G motif; other site 366394002104 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 366394002105 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 366394002106 Response regulator receiver domain; Region: Response_reg; pfam00072 366394002107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394002108 active site 366394002109 phosphorylation site [posttranslational modification] 366394002110 intermolecular recognition site; other site 366394002111 dimerization interface [polypeptide binding]; other site 366394002112 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394002113 DNA binding residues [nucleotide binding] 366394002114 dimerization interface [polypeptide binding]; other site 366394002115 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 366394002116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394002117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394002118 dimer interface [polypeptide binding]; other site 366394002119 phosphorylation site [posttranslational modification] 366394002120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394002121 ATP binding site [chemical binding]; other site 366394002122 Mg2+ binding site [ion binding]; other site 366394002123 G-X-G motif; other site 366394002124 Response regulator receiver domain; Region: Response_reg; pfam00072 366394002125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394002126 active site 366394002127 phosphorylation site [posttranslational modification] 366394002128 intermolecular recognition site; other site 366394002129 dimerization interface [polypeptide binding]; other site 366394002130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394002131 dimerization interface [polypeptide binding]; other site 366394002132 putative DNA binding site [nucleotide binding]; other site 366394002133 putative Zn2+ binding site [ion binding]; other site 366394002134 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 366394002135 putative hydrophobic ligand binding site [chemical binding]; other site 366394002136 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394002137 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 366394002138 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 366394002139 putative ligand binding site [chemical binding]; other site 366394002140 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 366394002141 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394002142 TM-ABC transporter signature motif; other site 366394002143 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 366394002144 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 366394002145 TM-ABC transporter signature motif; other site 366394002146 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 366394002147 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 366394002148 Walker A/P-loop; other site 366394002149 ATP binding site [chemical binding]; other site 366394002150 Q-loop/lid; other site 366394002151 ABC transporter signature motif; other site 366394002152 Walker B; other site 366394002153 D-loop; other site 366394002154 H-loop/switch region; other site 366394002155 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 366394002156 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 366394002157 Walker A/P-loop; other site 366394002158 ATP binding site [chemical binding]; other site 366394002159 Q-loop/lid; other site 366394002160 ABC transporter signature motif; other site 366394002161 Walker B; other site 366394002162 D-loop; other site 366394002163 H-loop/switch region; other site 366394002164 plasmid partitioning protein RepB; Provisional; Region: PRK13866 366394002165 ParB-like nuclease domain; Region: ParBc; pfam02195 366394002166 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 366394002167 MerR family regulatory protein; Region: MerR; pfam00376 366394002168 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 366394002169 P-loop; other site 366394002170 Magnesium ion binding site [ion binding]; other site 366394002171 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 366394002172 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 366394002173 Magnesium ion binding site [ion binding]; other site 366394002174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 366394002175 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394002176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 366394002177 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 366394002178 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 366394002179 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 366394002180 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 366394002181 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 366394002182 Predicted outer membrane protein [Function unknown]; Region: COG3652 366394002183 RNA polymerase sigma factor; Provisional; Region: PRK11922 366394002184 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 366394002185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 366394002186 acylphosphatase; Provisional; Region: PRK14425 366394002187 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 366394002188 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 366394002189 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 366394002190 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 366394002191 Moco binding site; other site 366394002192 metal coordination site [ion binding]; other site 366394002193 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 366394002194 Cupin domain; Region: Cupin_2; cl17218 366394002195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394002196 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 366394002197 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 366394002198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394002199 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 366394002200 putative dimerization interface [polypeptide binding]; other site 366394002201 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 366394002202 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 366394002203 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 366394002204 dimer interface [polypeptide binding]; other site 366394002205 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 366394002206 active site 366394002207 Fe binding site [ion binding]; other site 366394002208 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 366394002209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394002210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394002211 dimerization interface [polypeptide binding]; other site 366394002212 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 366394002213 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 366394002214 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 366394002215 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 366394002216 heterodimer interface [polypeptide binding]; other site 366394002217 multimer interface [polypeptide binding]; other site 366394002218 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 366394002219 active site 366394002220 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 366394002221 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 366394002222 heterodimer interface [polypeptide binding]; other site 366394002223 active site 366394002224 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975 366394002225 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 366394002226 tetramer interface [polypeptide binding]; other site 366394002227 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 366394002228 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 366394002229 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 366394002230 active site 366394002231 catalytic site [active] 366394002232 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 366394002233 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 366394002234 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 366394002235 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 366394002236 active site 366394002237 non-prolyl cis peptide bond; other site 366394002238 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 366394002239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394002240 dimer interface [polypeptide binding]; other site 366394002241 conserved gate region; other site 366394002242 putative PBP binding loops; other site 366394002243 ABC-ATPase subunit interface; other site 366394002244 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 366394002245 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394002246 substrate binding pocket [chemical binding]; other site 366394002247 membrane-bound complex binding site; other site 366394002248 hinge residues; other site 366394002249 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 366394002250 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 366394002251 Walker A/P-loop; other site 366394002252 ATP binding site [chemical binding]; other site 366394002253 Q-loop/lid; other site 366394002254 ABC transporter signature motif; other site 366394002255 Walker B; other site 366394002256 D-loop; other site 366394002257 H-loop/switch region; other site 366394002258 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 366394002259 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 366394002260 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 366394002261 TM-ABC transporter signature motif; other site 366394002262 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 366394002263 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 366394002264 TM-ABC transporter signature motif; other site 366394002265 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 366394002266 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 366394002267 Walker A/P-loop; other site 366394002268 ATP binding site [chemical binding]; other site 366394002269 Q-loop/lid; other site 366394002270 ABC transporter signature motif; other site 366394002271 Walker B; other site 366394002272 D-loop; other site 366394002273 H-loop/switch region; other site 366394002274 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 366394002275 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 366394002276 Walker A/P-loop; other site 366394002277 ATP binding site [chemical binding]; other site 366394002278 Q-loop/lid; other site 366394002279 ABC transporter signature motif; other site 366394002280 Walker B; other site 366394002281 D-loop; other site 366394002282 H-loop/switch region; other site 366394002283 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394002284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394002285 DNA-binding site [nucleotide binding]; DNA binding site 366394002286 FCD domain; Region: FCD; pfam07729 366394002287 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 366394002288 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 366394002289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 366394002290 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 366394002291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 366394002292 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 366394002293 dihydroxyacetone kinase; Provisional; Region: PRK14479 366394002294 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 366394002295 DAK2 domain; Region: Dak2; pfam02734 366394002296 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 366394002297 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 366394002298 trimer interface [polypeptide binding]; other site 366394002299 active site 366394002300 substrate binding site [chemical binding]; other site 366394002301 CoA binding site [chemical binding]; other site 366394002302 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 366394002303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394002304 Walker A/P-loop; other site 366394002305 ATP binding site [chemical binding]; other site 366394002306 Q-loop/lid; other site 366394002307 ABC transporter signature motif; other site 366394002308 Walker B; other site 366394002309 D-loop; other site 366394002310 H-loop/switch region; other site 366394002311 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 366394002312 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394002313 Walker A/P-loop; other site 366394002314 ATP binding site [chemical binding]; other site 366394002315 Q-loop/lid; other site 366394002316 ABC transporter signature motif; other site 366394002317 Walker B; other site 366394002318 D-loop; other site 366394002319 H-loop/switch region; other site 366394002320 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394002321 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 366394002322 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 366394002323 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 366394002324 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 366394002325 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 366394002326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394002327 DNA-binding site [nucleotide binding]; DNA binding site 366394002328 UTRA domain; Region: UTRA; pfam07702 366394002329 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 366394002330 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 366394002331 active site 366394002332 substrate binding site [chemical binding]; other site 366394002333 coenzyme B12 binding site [chemical binding]; other site 366394002334 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 366394002335 B12 binding site [chemical binding]; other site 366394002336 cobalt ligand [ion binding]; other site 366394002337 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 366394002338 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 366394002339 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 366394002340 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 366394002341 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 366394002342 carboxyltransferase (CT) interaction site; other site 366394002343 biotinylation site [posttranslational modification]; other site 366394002344 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 366394002345 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 366394002346 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 366394002347 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394002348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394002349 non-specific DNA binding site [nucleotide binding]; other site 366394002350 salt bridge; other site 366394002351 sequence-specific DNA binding site [nucleotide binding]; other site 366394002352 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 366394002353 Domain of unknown function (DUF955); Region: DUF955; pfam06114 366394002354 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 366394002355 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 366394002356 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 366394002357 substrate binding pocket [chemical binding]; other site 366394002358 FAD binding site [chemical binding]; other site 366394002359 catalytic base [active] 366394002360 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 366394002361 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 366394002362 substrate binding site [chemical binding]; other site 366394002363 oxyanion hole (OAH) forming residues; other site 366394002364 trimer interface [polypeptide binding]; other site 366394002365 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 366394002366 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 366394002367 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 366394002368 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 366394002369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394002370 NAD(P) binding site [chemical binding]; other site 366394002371 active site 366394002372 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 366394002373 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 366394002374 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 366394002375 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 366394002376 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 366394002377 active site 366394002378 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394002379 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394002380 DNA binding site [nucleotide binding] 366394002381 domain linker motif; other site 366394002382 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 366394002383 ligand binding site [chemical binding]; other site 366394002384 dimerization interface [polypeptide binding]; other site 366394002385 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 366394002386 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 366394002387 putative ligand binding site [chemical binding]; other site 366394002388 putative NAD binding site [chemical binding]; other site 366394002389 catalytic site [active] 366394002390 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 366394002391 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394002392 motif II; other site 366394002393 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 366394002394 glutamine synthetase; Region: PLN02284 366394002395 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 366394002396 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 366394002397 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 366394002398 Autotransporter beta-domain; Region: Autotransporter; pfam03797 366394002399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 366394002400 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 366394002401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 366394002402 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 366394002403 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 366394002404 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 366394002405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394002406 active site 366394002407 phosphorylation site [posttranslational modification] 366394002408 intermolecular recognition site; other site 366394002409 dimerization interface [polypeptide binding]; other site 366394002410 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394002411 DNA binding site [nucleotide binding] 366394002412 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 366394002413 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394002414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394002415 dimer interface [polypeptide binding]; other site 366394002416 phosphorylation site [posttranslational modification] 366394002417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394002418 ATP binding site [chemical binding]; other site 366394002419 Mg2+ binding site [ion binding]; other site 366394002420 G-X-G motif; other site 366394002421 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394002422 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 366394002423 putative ligand binding site [chemical binding]; other site 366394002424 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394002425 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394002426 TM-ABC transporter signature motif; other site 366394002427 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394002428 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394002429 Walker A/P-loop; other site 366394002430 ATP binding site [chemical binding]; other site 366394002431 Q-loop/lid; other site 366394002432 ABC transporter signature motif; other site 366394002433 Walker B; other site 366394002434 D-loop; other site 366394002435 H-loop/switch region; other site 366394002436 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394002437 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394002438 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394002439 DNA binding site [nucleotide binding] 366394002440 domain linker motif; other site 366394002441 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 366394002442 dimerization interface [polypeptide binding]; other site 366394002443 ligand binding site [chemical binding]; other site 366394002444 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394002445 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394002446 TM-ABC transporter signature motif; other site 366394002447 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394002448 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394002449 Walker A/P-loop; other site 366394002450 ATP binding site [chemical binding]; other site 366394002451 Q-loop/lid; other site 366394002452 ABC transporter signature motif; other site 366394002453 Walker B; other site 366394002454 D-loop; other site 366394002455 H-loop/switch region; other site 366394002456 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394002457 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394002458 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 366394002459 putative ligand binding site [chemical binding]; other site 366394002460 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 366394002461 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 366394002462 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 366394002463 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 366394002464 active site 366394002465 DNA binding site [nucleotide binding] 366394002466 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 366394002467 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 366394002468 DNA binding site [nucleotide binding] 366394002469 active site 366394002470 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394002471 cyclase homology domain; Region: CHD; cd07302 366394002472 nucleotidyl binding site; other site 366394002473 metal binding site [ion binding]; metal-binding site 366394002474 dimer interface [polypeptide binding]; other site 366394002475 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 366394002476 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394002477 substrate binding pocket [chemical binding]; other site 366394002478 membrane-bound complex binding site; other site 366394002479 hinge residues; other site 366394002480 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 366394002481 EamA-like transporter family; Region: EamA; pfam00892 366394002482 EamA-like transporter family; Region: EamA; pfam00892 366394002483 glycogen synthase; Provisional; Region: glgA; PRK00654 366394002484 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 366394002485 ADP-binding pocket [chemical binding]; other site 366394002486 homodimer interface [polypeptide binding]; other site 366394002487 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 366394002488 substrate binding site [chemical binding]; other site 366394002489 CheB methylesterase; Region: CheB_methylest; pfam01339 366394002490 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 366394002491 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 366394002492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394002493 S-adenosylmethionine binding site [chemical binding]; other site 366394002494 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 366394002495 PAS domain; Region: PAS; smart00091 366394002496 PAS domain; Region: PAS_10; pfam13596 366394002497 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 366394002498 HWE histidine kinase; Region: HWE_HK; smart00911 366394002499 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 366394002500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394002501 active site 366394002502 phosphorylation site [posttranslational modification] 366394002503 intermolecular recognition site; other site 366394002504 dimerization interface [polypeptide binding]; other site 366394002505 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 366394002506 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394002507 DNA binding site [nucleotide binding] 366394002508 Predicted integral membrane protein [Function unknown]; Region: COG5616 366394002509 TPR repeat; Region: TPR_11; pfam13414 366394002510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394002511 binding surface 366394002512 TPR motif; other site 366394002513 TPR repeat; Region: TPR_11; pfam13414 366394002514 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 366394002515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394002516 NAD(P) binding site [chemical binding]; other site 366394002517 active site 366394002518 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 366394002519 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 366394002520 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 366394002521 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394002522 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 366394002523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394002524 putative substrate translocation pore; other site 366394002525 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 366394002526 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394002527 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394002528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394002529 dimer interface [polypeptide binding]; other site 366394002530 conserved gate region; other site 366394002531 putative PBP binding loops; other site 366394002532 ABC-ATPase subunit interface; other site 366394002533 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394002534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394002535 dimer interface [polypeptide binding]; other site 366394002536 conserved gate region; other site 366394002537 putative PBP binding loops; other site 366394002538 ABC-ATPase subunit interface; other site 366394002539 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394002540 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394002541 Walker A/P-loop; other site 366394002542 ATP binding site [chemical binding]; other site 366394002543 Q-loop/lid; other site 366394002544 ABC transporter signature motif; other site 366394002545 Walker B; other site 366394002546 D-loop; other site 366394002547 H-loop/switch region; other site 366394002548 histidinol dehydrogenase; Region: hisD; TIGR00069 366394002549 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 366394002550 NAD binding site [chemical binding]; other site 366394002551 dimerization interface [polypeptide binding]; other site 366394002552 product binding site; other site 366394002553 substrate binding site [chemical binding]; other site 366394002554 zinc binding site [ion binding]; other site 366394002555 catalytic residues [active] 366394002556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394002557 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394002558 NAD(P) binding site [chemical binding]; other site 366394002559 active site 366394002560 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394002561 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394002562 DNA binding site [nucleotide binding] 366394002563 domain linker motif; other site 366394002564 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 366394002565 putative dimerization interface [polypeptide binding]; other site 366394002566 putative ligand binding site [chemical binding]; other site 366394002567 Cupin domain; Region: Cupin_2; pfam07883 366394002568 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 366394002569 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 366394002570 Amidase; Region: Amidase; cl11426 366394002571 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 366394002572 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 366394002573 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 366394002574 putative catalytic site [active] 366394002575 putative phosphate binding site [ion binding]; other site 366394002576 active site 366394002577 metal binding site A [ion binding]; metal-binding site 366394002578 DNA binding site [nucleotide binding] 366394002579 putative AP binding site [nucleotide binding]; other site 366394002580 putative metal binding site B [ion binding]; other site 366394002581 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 366394002582 TPR repeat; Region: TPR_11; pfam13414 366394002583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394002584 binding surface 366394002585 TPR motif; other site 366394002586 TPR repeat; Region: TPR_11; pfam13414 366394002587 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 366394002588 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 366394002589 putative DNA binding site [nucleotide binding]; other site 366394002590 putative homodimer interface [polypeptide binding]; other site 366394002591 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 366394002592 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 366394002593 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 366394002594 active site 366394002595 DNA binding site [nucleotide binding] 366394002596 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 366394002597 DNA binding site [nucleotide binding] 366394002598 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 366394002599 nucleotide binding site [chemical binding]; other site 366394002600 hypothetical protein; Provisional; Region: PRK11171 366394002601 Cupin domain; Region: Cupin_2; pfam07883 366394002602 Cupin domain; Region: Cupin_2; pfam07883 366394002603 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 366394002604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394002605 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 366394002606 putative dimerization interface [polypeptide binding]; other site 366394002607 putative substrate binding pocket [chemical binding]; other site 366394002608 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 366394002609 Transcriptional regulator [Transcription]; Region: IclR; COG1414 366394002610 Bacterial transcriptional regulator; Region: IclR; pfam01614 366394002611 glyoxylate carboligase; Provisional; Region: PRK11269 366394002612 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 366394002613 PYR/PP interface [polypeptide binding]; other site 366394002614 dimer interface [polypeptide binding]; other site 366394002615 TPP binding site [chemical binding]; other site 366394002616 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 366394002617 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 366394002618 TPP-binding site [chemical binding]; other site 366394002619 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 366394002620 tartronate semialdehyde reductase; Provisional; Region: PRK15059 366394002621 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 366394002622 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 366394002623 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 366394002624 MOFRL family; Region: MOFRL; pfam05161 366394002625 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 366394002626 ureidoglycolate hydrolase; Provisional; Region: PRK13395 366394002627 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 366394002628 Uncharacterized conserved protein [Function unknown]; Region: COG3506 366394002629 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394002630 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394002631 DNA binding site [nucleotide binding] 366394002632 domain linker motif; other site 366394002633 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 366394002634 dimerization interface [polypeptide binding]; other site 366394002635 ligand binding site [chemical binding]; other site 366394002636 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394002637 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394002638 Walker A/P-loop; other site 366394002639 ATP binding site [chemical binding]; other site 366394002640 Q-loop/lid; other site 366394002641 ABC transporter signature motif; other site 366394002642 Walker B; other site 366394002643 D-loop; other site 366394002644 H-loop/switch region; other site 366394002645 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394002646 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 366394002647 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394002648 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394002649 TM-ABC transporter signature motif; other site 366394002650 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394002651 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 366394002652 putative ligand binding site [chemical binding]; other site 366394002653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 366394002654 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 366394002655 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 366394002656 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 366394002657 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394002658 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394002659 DNA binding site [nucleotide binding] 366394002660 domain linker motif; other site 366394002661 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 366394002662 putative dimerization interface [polypeptide binding]; other site 366394002663 putative ligand binding site [chemical binding]; other site 366394002664 putative aldolase; Validated; Region: PRK08130 366394002665 intersubunit interface [polypeptide binding]; other site 366394002666 active site 366394002667 Zn2+ binding site [ion binding]; other site 366394002668 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394002669 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394002670 DNA-binding site [nucleotide binding]; DNA binding site 366394002671 FCD domain; Region: FCD; pfam07729 366394002672 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394002673 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 366394002674 putative NAD(P) binding site [chemical binding]; other site 366394002675 active site 366394002676 putative substrate binding site [chemical binding]; other site 366394002677 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394002678 classical (c) SDRs; Region: SDR_c; cd05233 366394002679 NAD(P) binding site [chemical binding]; other site 366394002680 active site 366394002681 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394002682 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394002683 Walker A/P-loop; other site 366394002684 ATP binding site [chemical binding]; other site 366394002685 Q-loop/lid; other site 366394002686 ABC transporter signature motif; other site 366394002687 Walker B; other site 366394002688 D-loop; other site 366394002689 H-loop/switch region; other site 366394002690 TOBE domain; Region: TOBE; pfam03459 366394002691 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394002692 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394002693 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394002694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394002695 dimer interface [polypeptide binding]; other site 366394002696 conserved gate region; other site 366394002697 putative PBP binding loops; other site 366394002698 ABC-ATPase subunit interface; other site 366394002699 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394002700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394002701 dimer interface [polypeptide binding]; other site 366394002702 conserved gate region; other site 366394002703 putative PBP binding loops; other site 366394002704 ABC-ATPase subunit interface; other site 366394002705 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394002706 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394002707 active site 366394002708 catalytic tetrad [active] 366394002709 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 366394002710 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 366394002711 active site 366394002712 dimer interface [polypeptide binding]; other site 366394002713 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 366394002714 Ligand Binding Site [chemical binding]; other site 366394002715 Molecular Tunnel; other site 366394002716 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 366394002717 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 366394002718 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 366394002719 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 366394002720 acyl-activating enzyme (AAE) consensus motif; other site 366394002721 putative AMP binding site [chemical binding]; other site 366394002722 putative active site [active] 366394002723 putative CoA binding site [chemical binding]; other site 366394002724 NAD synthetase; Reviewed; Region: nadE; PRK00876 366394002725 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 366394002726 homodimer interface [polypeptide binding]; other site 366394002727 NAD binding pocket [chemical binding]; other site 366394002728 ATP binding pocket [chemical binding]; other site 366394002729 Mg binding site [ion binding]; other site 366394002730 active-site loop [active] 366394002731 septum formation inhibitor; Reviewed; Region: minC; PRK05177 366394002732 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 366394002733 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 366394002734 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 366394002735 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 366394002736 Switch I; other site 366394002737 Switch II; other site 366394002738 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 366394002739 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394002740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394002741 active site 366394002742 phosphorylation site [posttranslational modification] 366394002743 intermolecular recognition site; other site 366394002744 dimerization interface [polypeptide binding]; other site 366394002745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394002746 DNA binding residues [nucleotide binding] 366394002747 dimerization interface [polypeptide binding]; other site 366394002748 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 366394002749 Histidine kinase; Region: HisKA_3; pfam07730 366394002750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394002751 ATP binding site [chemical binding]; other site 366394002752 Mg2+ binding site [ion binding]; other site 366394002753 G-X-G motif; other site 366394002754 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 366394002755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 366394002756 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394002757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 366394002758 Methyltransferase domain; Region: Methyltransf_31; pfam13847 366394002759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394002760 S-adenosylmethionine binding site [chemical binding]; other site 366394002761 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 366394002762 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 366394002763 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 366394002764 Chain length determinant protein; Region: Wzz; pfam02706 366394002765 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 366394002766 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 366394002767 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 366394002768 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 366394002769 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 366394002770 putative active site [active] 366394002771 putative metal binding site [ion binding]; other site 366394002772 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394002773 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 366394002774 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394002775 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 366394002776 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 366394002777 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 366394002778 active site 366394002779 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 366394002780 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 366394002781 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 366394002782 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394002783 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 366394002784 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394002785 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 366394002786 AsnC family; Region: AsnC_trans_reg; pfam01037 366394002787 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664 366394002788 Protein of unknown function (DUF992); Region: DUF992; pfam06186 366394002789 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 366394002790 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 366394002791 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 366394002792 Subunit I/III interface [polypeptide binding]; other site 366394002793 Subunit III/IV interface [polypeptide binding]; other site 366394002794 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 366394002795 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 366394002796 D-pathway; other site 366394002797 Putative ubiquinol binding site [chemical binding]; other site 366394002798 Low-spin heme (heme b) binding site [chemical binding]; other site 366394002799 Putative water exit pathway; other site 366394002800 Binuclear center (heme o3/CuB) [ion binding]; other site 366394002801 K-pathway; other site 366394002802 Putative proton exit pathway; other site 366394002803 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 366394002804 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 366394002805 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 366394002806 metabolite-proton symporter; Region: 2A0106; TIGR00883 366394002807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394002808 putative substrate translocation pore; other site 366394002809 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 366394002810 RNA polymerase sigma factor; Provisional; Region: PRK12547 366394002811 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 366394002812 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 366394002813 DNA binding residues [nucleotide binding] 366394002814 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 366394002815 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 366394002816 FOG: CBS domain [General function prediction only]; Region: COG0517 366394002817 Protein of unknown function (DUF982); Region: DUF982; pfam06169 366394002818 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394002819 classical (c) SDRs; Region: SDR_c; cd05233 366394002820 NAD(P) binding site [chemical binding]; other site 366394002821 active site 366394002822 Low affinity iron permease; Region: Iron_permease; pfam04120 366394002823 Protein of unknown function (DUF982); Region: DUF982; pfam06169 366394002824 Protein of unknown function (DUF982); Region: DUF982; pfam06169 366394002825 Protein of unknown function (DUF982); Region: DUF982; pfam06169 366394002826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 366394002827 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 366394002828 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 366394002829 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 366394002830 Walker A/P-loop; other site 366394002831 ATP binding site [chemical binding]; other site 366394002832 Q-loop/lid; other site 366394002833 ABC transporter signature motif; other site 366394002834 Walker B; other site 366394002835 D-loop; other site 366394002836 H-loop/switch region; other site 366394002837 HlyD family secretion protein; Region: HlyD; pfam00529 366394002838 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 366394002839 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394002840 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 366394002841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394002842 DNA-binding site [nucleotide binding]; DNA binding site 366394002843 UTRA domain; Region: UTRA; pfam07702 366394002844 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 366394002845 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 366394002846 NAD binding site [chemical binding]; other site 366394002847 sugar binding site [chemical binding]; other site 366394002848 divalent metal binding site [ion binding]; other site 366394002849 tetramer (dimer of dimers) interface [polypeptide binding]; other site 366394002850 dimer interface [polypeptide binding]; other site 366394002851 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 366394002852 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 366394002853 substrate binding site [chemical binding]; other site 366394002854 ATP binding site [chemical binding]; other site 366394002855 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394002856 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394002857 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394002858 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394002859 Walker A/P-loop; other site 366394002860 ATP binding site [chemical binding]; other site 366394002861 Q-loop/lid; other site 366394002862 ABC transporter signature motif; other site 366394002863 Walker B; other site 366394002864 D-loop; other site 366394002865 H-loop/switch region; other site 366394002866 TOBE domain; Region: TOBE_2; pfam08402 366394002867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394002868 dimer interface [polypeptide binding]; other site 366394002869 conserved gate region; other site 366394002870 putative PBP binding loops; other site 366394002871 ABC-ATPase subunit interface; other site 366394002872 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394002873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394002874 dimer interface [polypeptide binding]; other site 366394002875 conserved gate region; other site 366394002876 putative PBP binding loops; other site 366394002877 ABC-ATPase subunit interface; other site 366394002878 Uncharacterized conserved protein [Function unknown]; Region: COG1415 366394002879 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 366394002880 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 366394002881 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 366394002882 glutathione s-transferase; Provisional; Region: PTZ00057 366394002883 GSH binding site (G-site) [chemical binding]; other site 366394002884 C-terminal domain interface [polypeptide binding]; other site 366394002885 dimer interface [polypeptide binding]; other site 366394002886 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 366394002887 dimer interface [polypeptide binding]; other site 366394002888 N-terminal domain interface [polypeptide binding]; other site 366394002889 substrate binding pocket (H-site) [chemical binding]; other site 366394002890 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 366394002891 Fe-S cluster binding site [ion binding]; other site 366394002892 active site 366394002893 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 366394002894 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 366394002895 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 366394002896 catalytic site [active] 366394002897 active site 366394002898 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 366394002899 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 366394002900 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 366394002901 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 366394002902 active site 366394002903 catalytic site [active] 366394002904 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 366394002905 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 366394002906 active site 366394002907 DNA binding site [nucleotide binding] 366394002908 Int/Topo IB signature motif; other site 366394002909 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 366394002910 BON domain; Region: BON; pfam04972 366394002911 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 366394002912 FOG: CBS domain [General function prediction only]; Region: COG0517 366394002913 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 366394002914 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 366394002915 Methyltransferase domain; Region: Methyltransf_23; pfam13489 366394002916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394002917 S-adenosylmethionine binding site [chemical binding]; other site 366394002918 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 366394002919 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 366394002920 putative ligand binding residues [chemical binding]; other site 366394002921 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 366394002922 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 366394002923 ABC-ATPase subunit interface; other site 366394002924 dimer interface [polypeptide binding]; other site 366394002925 putative PBP binding regions; other site 366394002926 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 366394002927 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 366394002928 Walker A/P-loop; other site 366394002929 ATP binding site [chemical binding]; other site 366394002930 Q-loop/lid; other site 366394002931 ABC transporter signature motif; other site 366394002932 Walker B; other site 366394002933 D-loop; other site 366394002934 H-loop/switch region; other site 366394002935 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 366394002936 FAD binding domain; Region: FAD_binding_4; pfam01565 366394002937 Berberine and berberine like; Region: BBE; pfam08031 366394002938 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 366394002939 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 366394002940 catalytic residue [active] 366394002941 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 366394002942 Ca2+ binding site [ion binding]; other site 366394002943 Uncharacterized conserved protein [Function unknown]; Region: COG3189 366394002944 Methyltransferase domain; Region: Methyltransf_23; pfam13489 366394002945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394002946 S-adenosylmethionine binding site [chemical binding]; other site 366394002947 Predicted periplasmic protein [Function unknown]; Region: COG3904 366394002948 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 366394002949 dimer interface [polypeptide binding]; other site 366394002950 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 366394002951 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394002952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394002953 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 366394002954 dimerization interface [polypeptide binding]; other site 366394002955 Predicted membrane protein [Function unknown]; Region: COG4125 366394002956 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 366394002957 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 366394002958 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 366394002959 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 366394002960 Mechanosensitive ion channel; Region: MS_channel; pfam00924 366394002961 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 366394002962 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394002963 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394002964 SnoaL-like domain; Region: SnoaL_2; pfam12680 366394002965 TspO/MBR family; Region: TspO_MBR; pfam03073 366394002966 Uncharacterized conserved protein [Function unknown]; Region: COG2155 366394002967 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 366394002968 Fasciclin domain; Region: Fasciclin; pfam02469 366394002969 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394002970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394002971 non-specific DNA binding site [nucleotide binding]; other site 366394002972 salt bridge; other site 366394002973 sequence-specific DNA binding site [nucleotide binding]; other site 366394002974 Cupin domain; Region: Cupin_2; pfam07883 366394002975 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394002976 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394002977 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 366394002978 putative effector binding pocket; other site 366394002979 putative dimerization interface [polypeptide binding]; other site 366394002980 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 366394002981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394002982 putative substrate translocation pore; other site 366394002983 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 366394002984 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 366394002985 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 366394002986 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 366394002987 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 366394002988 Uncharacterized conserved protein [Function unknown]; Region: COG4925 366394002989 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 366394002990 active site 366394002991 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 366394002992 DNA-binding site [nucleotide binding]; DNA binding site 366394002993 RNA-binding motif; other site 366394002994 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 366394002995 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394002996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394002997 non-specific DNA binding site [nucleotide binding]; other site 366394002998 salt bridge; other site 366394002999 sequence-specific DNA binding site [nucleotide binding]; other site 366394003000 HipA N-terminal domain; Region: Couple_hipA; cl11853 366394003001 HipA-like N-terminal domain; Region: HipA_N; pfam07805 366394003002 HipA-like C-terminal domain; Region: HipA_C; pfam07804 366394003003 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 366394003004 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394003005 Walker A/P-loop; other site 366394003006 ATP binding site [chemical binding]; other site 366394003007 Q-loop/lid; other site 366394003008 ABC transporter signature motif; other site 366394003009 Walker B; other site 366394003010 D-loop; other site 366394003011 H-loop/switch region; other site 366394003012 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394003013 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394003014 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394003015 TM-ABC transporter signature motif; other site 366394003016 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 366394003017 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 366394003018 putative ligand binding site [chemical binding]; other site 366394003019 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 366394003020 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 366394003021 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 366394003022 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394003023 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394003024 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394003025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394003026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394003027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394003028 dimerization interface [polypeptide binding]; other site 366394003029 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 366394003030 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 366394003031 putative ligand binding site [chemical binding]; other site 366394003032 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394003033 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394003034 Walker A/P-loop; other site 366394003035 ATP binding site [chemical binding]; other site 366394003036 Q-loop/lid; other site 366394003037 ABC transporter signature motif; other site 366394003038 Walker B; other site 366394003039 D-loop; other site 366394003040 H-loop/switch region; other site 366394003041 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394003042 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394003043 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394003044 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394003045 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394003046 TM-ABC transporter signature motif; other site 366394003047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 366394003048 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 366394003049 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 366394003050 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 366394003051 NAD(P) binding site [chemical binding]; other site 366394003052 catalytic residues [active] 366394003053 dihydroxy-acid dehydratase; Validated; Region: PRK06131 366394003054 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 366394003055 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 366394003056 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 366394003057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 366394003058 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 366394003059 Uncharacterized conserved protein [Function unknown]; Region: COG2308 366394003060 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 366394003061 EamA-like transporter family; Region: EamA; pfam00892 366394003062 helicase 45; Provisional; Region: PTZ00424 366394003063 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 366394003064 ATP binding site [chemical binding]; other site 366394003065 Mg++ binding site [ion binding]; other site 366394003066 motif III; other site 366394003067 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 366394003068 nucleotide binding region [chemical binding]; other site 366394003069 ATP-binding site [chemical binding]; other site 366394003070 Protein required for attachment to host cells; Region: Host_attach; cl02398 366394003071 Uncharacterized conserved protein [Function unknown]; Region: COG4121 366394003072 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394003073 Protein of unknown function (DUF1045); Region: DUF1045; pfam06299 366394003074 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 366394003075 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 366394003076 active site 366394003077 catalytic site [active] 366394003078 tetramer interface [polypeptide binding]; other site 366394003079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 366394003080 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 366394003081 ureidoglycolate hydrolase; Provisional; Region: PRK03606 366394003082 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 366394003083 active site 366394003084 homotetramer interface [polypeptide binding]; other site 366394003085 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 366394003086 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 366394003087 phosphate binding site [ion binding]; other site 366394003088 guanine deaminase; Provisional; Region: PRK09228 366394003089 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 366394003090 active site 366394003091 Predicted membrane protein [Function unknown]; Region: COG3748 366394003092 Protein of unknown function (DUF989); Region: DUF989; pfam06181 366394003093 Cytochrome c; Region: Cytochrom_C; pfam00034 366394003094 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 366394003095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394003096 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 366394003097 dimerization interface [polypeptide binding]; other site 366394003098 substrate binding pocket [chemical binding]; other site 366394003099 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 366394003100 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 366394003101 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 366394003102 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 366394003103 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394003104 catalytic loop [active] 366394003105 iron binding site [ion binding]; other site 366394003106 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 366394003107 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 366394003108 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 366394003109 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 366394003110 NAD binding site [chemical binding]; other site 366394003111 homotetramer interface [polypeptide binding]; other site 366394003112 homodimer interface [polypeptide binding]; other site 366394003113 substrate binding site [chemical binding]; other site 366394003114 active site 366394003115 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 366394003116 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 366394003117 N- and C-terminal domain interface [polypeptide binding]; other site 366394003118 active site 366394003119 MgATP binding site [chemical binding]; other site 366394003120 catalytic site [active] 366394003121 metal binding site [ion binding]; metal-binding site 366394003122 glycerol binding site [chemical binding]; other site 366394003123 homotetramer interface [polypeptide binding]; other site 366394003124 homodimer interface [polypeptide binding]; other site 366394003125 FBP binding site [chemical binding]; other site 366394003126 protein IIAGlc interface [polypeptide binding]; other site 366394003127 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394003128 dimerization interface [polypeptide binding]; other site 366394003129 putative DNA binding site [nucleotide binding]; other site 366394003130 putative Zn2+ binding site [ion binding]; other site 366394003131 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 366394003132 putative hydrophobic ligand binding site [chemical binding]; other site 366394003133 Uncharacterized conserved protein [Function unknown]; Region: COG5649 366394003134 Uncharacterized conserved protein [Function unknown]; Region: COG5649 366394003135 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 366394003136 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 366394003137 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 366394003138 active site 366394003139 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 366394003140 microcin B17 transporter; Reviewed; Region: PRK11098 366394003141 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 366394003142 NodB motif; other site 366394003143 putative active site [active] 366394003144 putative catalytic site [active] 366394003145 Predicted membrane protein [Function unknown]; Region: COG4094 366394003146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 366394003147 GTP-binding protein Der; Reviewed; Region: PRK00093 366394003148 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 366394003149 G1 box; other site 366394003150 GTP/Mg2+ binding site [chemical binding]; other site 366394003151 Switch I region; other site 366394003152 G2 box; other site 366394003153 Switch II region; other site 366394003154 G3 box; other site 366394003155 G4 box; other site 366394003156 G5 box; other site 366394003157 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 366394003158 G1 box; other site 366394003159 GTP/Mg2+ binding site [chemical binding]; other site 366394003160 Switch I region; other site 366394003161 G2 box; other site 366394003162 G3 box; other site 366394003163 Switch II region; other site 366394003164 G4 box; other site 366394003165 G5 box; other site 366394003166 Rrf2 family protein; Region: rrf2_super; TIGR00738 366394003167 Transcriptional regulator; Region: Rrf2; pfam02082 366394003168 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 366394003169 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 366394003170 active site 366394003171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 366394003172 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 366394003173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 366394003174 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 366394003175 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 366394003176 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 366394003177 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 366394003178 dimer interface [polypeptide binding]; other site 366394003179 active site residues [active] 366394003180 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 366394003181 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 366394003182 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 366394003183 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 366394003184 nudix motif; other site 366394003185 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 366394003186 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 366394003187 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 366394003188 Uroporphyrinogen-III methylase [Coenzyme metabolism]; Region: CysG; COG0007 366394003189 homodimer interface [polypeptide binding]; other site 366394003190 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 366394003191 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 366394003192 [4Fe-4S] binding site [ion binding]; other site 366394003193 molybdopterin cofactor binding site; other site 366394003194 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 366394003195 molybdopterin cofactor binding site; other site 366394003196 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 366394003197 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 366394003198 [2Fe-2S] cluster binding site [ion binding]; other site 366394003199 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 366394003200 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394003201 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 366394003202 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 366394003203 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 366394003204 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 366394003205 NMT1-like family; Region: NMT1_2; pfam13379 366394003206 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 366394003207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394003208 active site 366394003209 phosphorylation site [posttranslational modification] 366394003210 intermolecular recognition site; other site 366394003211 ANTAR domain; Region: ANTAR; pfam03861 366394003212 Uncharacterized conserved protein [Function unknown]; Region: COG3482 366394003213 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394003214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394003215 non-specific DNA binding site [nucleotide binding]; other site 366394003216 salt bridge; other site 366394003217 sequence-specific DNA binding site [nucleotide binding]; other site 366394003218 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 366394003219 Shikimate kinase; Region: SKI; pfam01202 366394003220 isovaleryl-CoA dehydrogenase; Region: PLN02519 366394003221 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 366394003222 substrate binding site [chemical binding]; other site 366394003223 FAD binding site [chemical binding]; other site 366394003224 catalytic base [active] 366394003225 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 366394003226 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 366394003227 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 366394003228 homotrimer interaction site [polypeptide binding]; other site 366394003229 putative active site [active] 366394003230 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 366394003231 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 366394003232 ATP-grasp domain; Region: ATP-grasp_4; cl17255 366394003233 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 366394003234 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 366394003235 carboxyltransferase (CT) interaction site; other site 366394003236 biotinylation site [posttranslational modification]; other site 366394003237 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 366394003238 active site 366394003239 catalytic residues [active] 366394003240 metal binding site [ion binding]; metal-binding site 366394003241 enoyl-CoA hydratase; Provisional; Region: PRK07468 366394003242 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 366394003243 substrate binding site [chemical binding]; other site 366394003244 oxyanion hole (OAH) forming residues; other site 366394003245 trimer interface [polypeptide binding]; other site 366394003246 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 366394003247 Uncharacterized conserved protein [Function unknown]; Region: COG5654 366394003248 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 366394003249 FAD binding domain; Region: FAD_binding_4; pfam01565 366394003250 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 366394003251 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 366394003252 Walker A/P-loop; other site 366394003253 ATP binding site [chemical binding]; other site 366394003254 Q-loop/lid; other site 366394003255 ABC transporter signature motif; other site 366394003256 Walker B; other site 366394003257 D-loop; other site 366394003258 H-loop/switch region; other site 366394003259 TOBE-like domain; Region: TOBE_3; pfam12857 366394003260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003261 dimer interface [polypeptide binding]; other site 366394003262 conserved gate region; other site 366394003263 putative PBP binding loops; other site 366394003264 ABC-ATPase subunit interface; other site 366394003265 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 366394003266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003267 dimer interface [polypeptide binding]; other site 366394003268 conserved gate region; other site 366394003269 putative PBP binding loops; other site 366394003270 ABC-ATPase subunit interface; other site 366394003271 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 366394003272 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 366394003273 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 366394003274 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 366394003275 dimer interface [polypeptide binding]; other site 366394003276 active site 366394003277 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 366394003278 substrate binding site [chemical binding]; other site 366394003279 catalytic residue [active] 366394003280 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 366394003281 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394003282 substrate binding pocket [chemical binding]; other site 366394003283 membrane-bound complex binding site; other site 366394003284 hinge residues; other site 366394003285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003286 dimer interface [polypeptide binding]; other site 366394003287 conserved gate region; other site 366394003288 putative PBP binding loops; other site 366394003289 ABC-ATPase subunit interface; other site 366394003290 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 366394003291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003292 dimer interface [polypeptide binding]; other site 366394003293 conserved gate region; other site 366394003294 putative PBP binding loops; other site 366394003295 ABC-ATPase subunit interface; other site 366394003296 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 366394003297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394003298 Walker A/P-loop; other site 366394003299 ATP binding site [chemical binding]; other site 366394003300 Q-loop/lid; other site 366394003301 ABC transporter signature motif; other site 366394003302 Walker B; other site 366394003303 D-loop; other site 366394003304 H-loop/switch region; other site 366394003305 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 366394003306 homotrimer interaction site [polypeptide binding]; other site 366394003307 putative active site [active] 366394003308 Transcriptional regulator [Transcription]; Region: IclR; COG1414 366394003309 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 366394003310 Bacterial transcriptional regulator; Region: IclR; pfam01614 366394003311 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394003312 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394003313 Walker A/P-loop; other site 366394003314 ATP binding site [chemical binding]; other site 366394003315 Q-loop/lid; other site 366394003316 ABC transporter signature motif; other site 366394003317 Walker B; other site 366394003318 D-loop; other site 366394003319 H-loop/switch region; other site 366394003320 TOBE domain; Region: TOBE_2; pfam08402 366394003321 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 366394003322 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 366394003323 substrate binding site [chemical binding]; other site 366394003324 ATP binding site [chemical binding]; other site 366394003325 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 366394003326 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 366394003327 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 366394003328 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394003329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003330 dimer interface [polypeptide binding]; other site 366394003331 conserved gate region; other site 366394003332 putative PBP binding loops; other site 366394003333 ABC-ATPase subunit interface; other site 366394003334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003335 dimer interface [polypeptide binding]; other site 366394003336 conserved gate region; other site 366394003337 putative PBP binding loops; other site 366394003338 ABC-ATPase subunit interface; other site 366394003339 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394003340 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 366394003341 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 366394003342 non-specific DNA interactions [nucleotide binding]; other site 366394003343 DNA binding site [nucleotide binding] 366394003344 sequence specific DNA binding site [nucleotide binding]; other site 366394003345 putative cAMP binding site [chemical binding]; other site 366394003346 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 366394003347 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 366394003348 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 366394003349 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 366394003350 Active Sites [active] 366394003351 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 366394003352 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 366394003353 CysD dimerization site [polypeptide binding]; other site 366394003354 G1 box; other site 366394003355 putative GEF interaction site [polypeptide binding]; other site 366394003356 GTP/Mg2+ binding site [chemical binding]; other site 366394003357 Switch I region; other site 366394003358 G2 box; other site 366394003359 G3 box; other site 366394003360 Switch II region; other site 366394003361 G4 box; other site 366394003362 G5 box; other site 366394003363 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 366394003364 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 366394003365 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 366394003366 ligand-binding site [chemical binding]; other site 366394003367 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 366394003368 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 366394003369 active site 366394003370 PHP domain; Region: PHP; pfam02811 366394003371 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 366394003372 active site 366394003373 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 366394003374 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 366394003375 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394003376 extended (e) SDRs; Region: SDR_e; cd08946 366394003377 NAD(P) binding site [chemical binding]; other site 366394003378 active site 366394003379 substrate binding site [chemical binding]; other site 366394003380 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 366394003381 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 366394003382 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 366394003383 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 366394003384 putative ADP-binding pocket [chemical binding]; other site 366394003385 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 366394003386 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394003387 putative ADP-binding pocket [chemical binding]; other site 366394003388 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 366394003389 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 366394003390 NAD(P) binding site [chemical binding]; other site 366394003391 homodimer interface [polypeptide binding]; other site 366394003392 substrate binding site [chemical binding]; other site 366394003393 active site 366394003394 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 366394003395 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651 366394003396 putative active site [active] 366394003397 putative substrate binding site [chemical binding]; other site 366394003398 putative cosubstrate binding site; other site 366394003399 catalytic site [active] 366394003400 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 366394003401 active site 366394003402 hexamer interface [polypeptide binding]; other site 366394003403 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 366394003404 Chain length determinant protein; Region: Wzz; pfam02706 366394003405 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 366394003406 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 366394003407 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394003408 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 366394003409 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 366394003410 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 366394003411 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 366394003412 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 366394003413 SLBB domain; Region: SLBB; pfam10531 366394003414 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 366394003415 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 366394003416 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 366394003417 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 366394003418 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 366394003419 inhibitor-cofactor binding pocket; inhibition site 366394003420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394003421 catalytic residue [active] 366394003422 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 366394003423 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394003424 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 366394003425 putative ADP-binding pocket [chemical binding]; other site 366394003426 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 366394003427 Mechanosensitive ion channel; Region: MS_channel; pfam00924 366394003428 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394003429 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 366394003430 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 366394003431 NodB motif; other site 366394003432 putative active site [active] 366394003433 putative catalytic site [active] 366394003434 putative Zn binding site [ion binding]; other site 366394003435 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 366394003436 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 366394003437 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 366394003438 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 366394003439 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 366394003440 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 366394003441 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394003442 cyclase homology domain; Region: CHD; cd07302 366394003443 nucleotidyl binding site; other site 366394003444 metal binding site [ion binding]; metal-binding site 366394003445 dimer interface [polypeptide binding]; other site 366394003446 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 366394003447 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 366394003448 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394003449 Walker A/P-loop; other site 366394003450 ATP binding site [chemical binding]; other site 366394003451 Q-loop/lid; other site 366394003452 ABC transporter signature motif; other site 366394003453 Walker B; other site 366394003454 D-loop; other site 366394003455 H-loop/switch region; other site 366394003456 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 366394003457 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394003458 Walker A/P-loop; other site 366394003459 ATP binding site [chemical binding]; other site 366394003460 Q-loop/lid; other site 366394003461 ABC transporter signature motif; other site 366394003462 Walker B; other site 366394003463 D-loop; other site 366394003464 H-loop/switch region; other site 366394003465 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394003466 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 366394003467 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 366394003468 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394003469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003470 dimer interface [polypeptide binding]; other site 366394003471 conserved gate region; other site 366394003472 putative PBP binding loops; other site 366394003473 ABC-ATPase subunit interface; other site 366394003474 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 366394003475 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 366394003476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003477 dimer interface [polypeptide binding]; other site 366394003478 conserved gate region; other site 366394003479 putative PBP binding loops; other site 366394003480 ABC-ATPase subunit interface; other site 366394003481 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 366394003482 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 366394003483 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 366394003484 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 366394003485 putative ADP-binding pocket [chemical binding]; other site 366394003486 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 366394003487 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 366394003488 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 366394003489 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 366394003490 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 366394003491 Walker A/P-loop; other site 366394003492 ATP binding site [chemical binding]; other site 366394003493 Q-loop/lid; other site 366394003494 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 366394003495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394003496 ABC transporter signature motif; other site 366394003497 Walker B; other site 366394003498 D-loop; other site 366394003499 H-loop/switch region; other site 366394003500 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 366394003501 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 366394003502 ligand binding site [chemical binding]; other site 366394003503 flexible hinge region; other site 366394003504 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 366394003505 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394003506 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394003507 DNA binding site [nucleotide binding] 366394003508 domain linker motif; other site 366394003509 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 366394003510 dimerization interface [polypeptide binding]; other site 366394003511 ligand binding site [chemical binding]; other site 366394003512 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 366394003513 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394003514 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394003515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003516 putative PBP binding loops; other site 366394003517 dimer interface [polypeptide binding]; other site 366394003518 ABC-ATPase subunit interface; other site 366394003519 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394003520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003521 dimer interface [polypeptide binding]; other site 366394003522 conserved gate region; other site 366394003523 putative PBP binding loops; other site 366394003524 ABC-ATPase subunit interface; other site 366394003525 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394003526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394003527 Walker A/P-loop; other site 366394003528 ATP binding site [chemical binding]; other site 366394003529 Q-loop/lid; other site 366394003530 ABC transporter signature motif; other site 366394003531 Walker B; other site 366394003532 D-loop; other site 366394003533 H-loop/switch region; other site 366394003534 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 366394003535 active site 366394003536 tetramer interface [polypeptide binding]; other site 366394003537 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 366394003538 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 366394003539 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 366394003540 active site 366394003541 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 366394003542 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 366394003543 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 366394003544 metal binding site [ion binding]; metal-binding site 366394003545 putative dimer interface [polypeptide binding]; other site 366394003546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 366394003547 active site 366394003548 Predicted metal-binding protein [General function prediction only]; Region: COG3019 366394003549 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 366394003550 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 366394003551 active site 366394003552 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 366394003553 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 366394003554 active site 366394003555 catalytic site [active] 366394003556 tetramer interface [polypeptide binding]; other site 366394003557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 366394003558 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 366394003559 active site 366394003560 homotetramer interface [polypeptide binding]; other site 366394003561 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 366394003562 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394003563 catalytic loop [active] 366394003564 iron binding site [ion binding]; other site 366394003565 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 366394003566 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 366394003567 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 366394003568 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 366394003569 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 366394003570 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 366394003571 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 366394003572 XdhC Rossmann domain; Region: XdhC_C; pfam13478 366394003573 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394003574 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394003575 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 366394003576 putative effector binding pocket; other site 366394003577 dimerization interface [polypeptide binding]; other site 366394003578 Predicted membrane protein [Function unknown]; Region: COG3748 366394003579 Protein of unknown function (DUF989); Region: DUF989; pfam06181 366394003580 Cytochrome c; Region: Cytochrom_C; pfam00034 366394003581 guanine deaminase; Provisional; Region: PRK09228 366394003582 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 366394003583 active site 366394003584 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 366394003585 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 366394003586 putative dimer interface [polypeptide binding]; other site 366394003587 Protein of unknown function (DUF982); Region: DUF982; pfam06169 366394003588 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 366394003589 Transglycosylase; Region: Transgly; pfam00912 366394003590 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 366394003591 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 366394003592 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 366394003593 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 366394003594 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 366394003595 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 366394003596 intersubunit interface [polypeptide binding]; other site 366394003597 active site 366394003598 catalytic residue [active] 366394003599 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 366394003600 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 366394003601 NAD(P) binding site [chemical binding]; other site 366394003602 catalytic residues [active] 366394003603 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 366394003604 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 366394003605 NAD(P) binding site [chemical binding]; other site 366394003606 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 366394003607 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 366394003608 Amidinotransferase; Region: Amidinotransf; cl12043 366394003609 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 366394003610 mercuric reductase; Validated; Region: PRK06370 366394003611 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 366394003612 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394003613 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 366394003614 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 366394003615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003616 dimer interface [polypeptide binding]; other site 366394003617 conserved gate region; other site 366394003618 ABC-ATPase subunit interface; other site 366394003619 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 366394003620 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 366394003621 Walker A/P-loop; other site 366394003622 ATP binding site [chemical binding]; other site 366394003623 Q-loop/lid; other site 366394003624 ABC transporter signature motif; other site 366394003625 Walker B; other site 366394003626 D-loop; other site 366394003627 H-loop/switch region; other site 366394003628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003629 dimer interface [polypeptide binding]; other site 366394003630 conserved gate region; other site 366394003631 putative PBP binding loops; other site 366394003632 ABC-ATPase subunit interface; other site 366394003633 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394003634 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394003635 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 366394003636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003637 dimer interface [polypeptide binding]; other site 366394003638 conserved gate region; other site 366394003639 putative PBP binding loops; other site 366394003640 ABC-ATPase subunit interface; other site 366394003641 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394003642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003643 dimer interface [polypeptide binding]; other site 366394003644 conserved gate region; other site 366394003645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 366394003646 ABC-ATPase subunit interface; other site 366394003647 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 366394003648 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394003649 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394003650 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394003651 Walker A/P-loop; other site 366394003652 ATP binding site [chemical binding]; other site 366394003653 Q-loop/lid; other site 366394003654 ABC transporter signature motif; other site 366394003655 Walker B; other site 366394003656 D-loop; other site 366394003657 H-loop/switch region; other site 366394003658 TOBE domain; Region: TOBE_2; pfam08402 366394003659 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 366394003660 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394003661 Coenzyme A binding pocket [chemical binding]; other site 366394003662 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 366394003663 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394003664 active site 366394003665 Uncharacterized conserved protein [Function unknown]; Region: COG5476 366394003666 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 366394003667 MlrC C-terminus; Region: MlrC_C; pfam07171 366394003668 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 366394003669 homotrimer interaction site [polypeptide binding]; other site 366394003670 putative active site [active] 366394003671 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 366394003672 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 366394003673 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 366394003674 putative active site [active] 366394003675 short chain dehydrogenase; Provisional; Region: PRK07074 366394003676 classical (c) SDRs; Region: SDR_c; cd05233 366394003677 NAD(P) binding site [chemical binding]; other site 366394003678 active site 366394003679 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 366394003680 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 366394003681 active site 366394003682 Uncharacterized conserved protein [Function unknown]; Region: COG5476 366394003683 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 366394003684 MlrC C-terminus; Region: MlrC_C; pfam07171 366394003685 urocanate hydratase; Provisional; Region: PRK05414 366394003686 N-formylglutamate amidohydrolase; Region: FGase; cl01522 366394003687 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 366394003688 active sites [active] 366394003689 tetramer interface [polypeptide binding]; other site 366394003690 imidazolonepropionase; Validated; Region: PRK09356 366394003691 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 366394003692 active site 366394003693 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 366394003694 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394003695 dimerization interface [polypeptide binding]; other site 366394003696 putative DNA binding site [nucleotide binding]; other site 366394003697 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 366394003698 Guanylate kinase; Region: Guanylate_kin; pfam00625 366394003699 active site 366394003700 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 366394003701 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 366394003702 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 366394003703 active site 366394003704 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 366394003705 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 366394003706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003707 dimer interface [polypeptide binding]; other site 366394003708 conserved gate region; other site 366394003709 ABC-ATPase subunit interface; other site 366394003710 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 366394003711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003712 dimer interface [polypeptide binding]; other site 366394003713 conserved gate region; other site 366394003714 ABC-ATPase subunit interface; other site 366394003715 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 366394003716 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 366394003717 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 366394003718 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 366394003719 Walker A/P-loop; other site 366394003720 ATP binding site [chemical binding]; other site 366394003721 Q-loop/lid; other site 366394003722 ABC transporter signature motif; other site 366394003723 Walker B; other site 366394003724 D-loop; other site 366394003725 H-loop/switch region; other site 366394003726 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394003727 hydroxyglutarate oxidase; Provisional; Region: PRK11728 366394003728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394003729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394003730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 366394003731 dimerization interface [polypeptide binding]; other site 366394003732 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 366394003733 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 366394003734 FAD binding site [chemical binding]; other site 366394003735 substrate binding pocket [chemical binding]; other site 366394003736 catalytic base [active] 366394003737 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 366394003738 CoA-transferase family III; Region: CoA_transf_3; pfam02515 366394003739 heat shock protein 90; Provisional; Region: PRK05218 366394003740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394003741 ATP binding site [chemical binding]; other site 366394003742 Mg2+ binding site [ion binding]; other site 366394003743 G-X-G motif; other site 366394003744 phosphate acetyltransferase; Provisional; Region: PRK11890 366394003745 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 366394003746 propionate/acetate kinase; Provisional; Region: PRK12379 366394003747 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 366394003748 succinic semialdehyde dehydrogenase; Region: PLN02278 366394003749 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 366394003750 tetramerization interface [polypeptide binding]; other site 366394003751 NAD(P) binding site [chemical binding]; other site 366394003752 catalytic residues [active] 366394003753 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 366394003754 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 366394003755 inhibitor-cofactor binding pocket; inhibition site 366394003756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394003757 catalytic residue [active] 366394003758 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 366394003759 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 366394003760 DNA binding residues [nucleotide binding] 366394003761 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 366394003762 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394003763 non-specific DNA binding site [nucleotide binding]; other site 366394003764 salt bridge; other site 366394003765 sequence-specific DNA binding site [nucleotide binding]; other site 366394003766 Cupin domain; Region: Cupin_2; pfam07883 366394003767 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 366394003768 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 366394003769 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 366394003770 active site 366394003771 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 366394003772 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 366394003773 active site 366394003774 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 366394003775 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 366394003776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394003777 Walker A/P-loop; other site 366394003778 ATP binding site [chemical binding]; other site 366394003779 Q-loop/lid; other site 366394003780 ABC transporter signature motif; other site 366394003781 Walker B; other site 366394003782 D-loop; other site 366394003783 H-loop/switch region; other site 366394003784 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 366394003785 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 366394003786 intersubunit interface [polypeptide binding]; other site 366394003787 active site 366394003788 zinc binding site [ion binding]; other site 366394003789 Na+ binding site [ion binding]; other site 366394003790 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 366394003791 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 366394003792 peptide binding site [polypeptide binding]; other site 366394003793 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 366394003794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003795 dimer interface [polypeptide binding]; other site 366394003796 conserved gate region; other site 366394003797 putative PBP binding loops; other site 366394003798 ABC-ATPase subunit interface; other site 366394003799 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 366394003800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394003801 dimer interface [polypeptide binding]; other site 366394003802 conserved gate region; other site 366394003803 ABC-ATPase subunit interface; other site 366394003804 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 366394003805 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394003806 Walker A/P-loop; other site 366394003807 ATP binding site [chemical binding]; other site 366394003808 Q-loop/lid; other site 366394003809 ABC transporter signature motif; other site 366394003810 Walker B; other site 366394003811 D-loop; other site 366394003812 H-loop/switch region; other site 366394003813 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394003814 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394003815 Walker A/P-loop; other site 366394003816 ATP binding site [chemical binding]; other site 366394003817 Q-loop/lid; other site 366394003818 ABC transporter signature motif; other site 366394003819 Walker B; other site 366394003820 D-loop; other site 366394003821 H-loop/switch region; other site 366394003822 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394003823 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 366394003824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394003825 active site 366394003826 phosphorylation site [posttranslational modification] 366394003827 intermolecular recognition site; other site 366394003828 dimerization interface [polypeptide binding]; other site 366394003829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394003830 Walker A motif; other site 366394003831 ATP binding site [chemical binding]; other site 366394003832 Walker B motif; other site 366394003833 arginine finger; other site 366394003834 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 366394003835 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 366394003836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394003837 dimer interface [polypeptide binding]; other site 366394003838 phosphorylation site [posttranslational modification] 366394003839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394003840 ATP binding site [chemical binding]; other site 366394003841 Mg2+ binding site [ion binding]; other site 366394003842 G-X-G motif; other site 366394003843 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 366394003844 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394003845 Zn binding site [ion binding]; other site 366394003846 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 366394003847 Zn binding site [ion binding]; other site 366394003848 Predicted esterase [General function prediction only]; Region: COG0400 366394003849 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 366394003850 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 366394003851 putative active site [active] 366394003852 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 366394003853 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 366394003854 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 366394003855 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 366394003856 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 366394003857 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 366394003858 Walker A/P-loop; other site 366394003859 ATP binding site [chemical binding]; other site 366394003860 Q-loop/lid; other site 366394003861 ABC transporter signature motif; other site 366394003862 Walker B; other site 366394003863 D-loop; other site 366394003864 H-loop/switch region; other site 366394003865 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 366394003866 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 366394003867 Walker A/P-loop; other site 366394003868 ATP binding site [chemical binding]; other site 366394003869 Q-loop/lid; other site 366394003870 ABC transporter signature motif; other site 366394003871 Walker B; other site 366394003872 D-loop; other site 366394003873 H-loop/switch region; other site 366394003874 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 366394003875 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 366394003876 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394003877 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 366394003878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394003879 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 366394003880 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 366394003881 active site 366394003882 metal binding site [ion binding]; metal-binding site 366394003883 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394003884 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 366394003885 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 366394003886 active site 366394003887 metal binding site [ion binding]; metal-binding site 366394003888 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 366394003889 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394003890 motif I; other site 366394003891 active site 366394003892 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394003893 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 366394003894 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394003895 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 366394003896 Methyltransferase domain; Region: Methyltransf_23; pfam13489 366394003897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394003898 S-adenosylmethionine binding site [chemical binding]; other site 366394003899 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 366394003900 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 366394003901 active site 366394003902 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 366394003903 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 366394003904 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 366394003905 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394003906 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 366394003907 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 366394003908 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 366394003909 Walker A/P-loop; other site 366394003910 ATP binding site [chemical binding]; other site 366394003911 Q-loop/lid; other site 366394003912 ABC transporter signature motif; other site 366394003913 Walker B; other site 366394003914 D-loop; other site 366394003915 H-loop/switch region; other site 366394003916 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 366394003917 MarR family; Region: MarR_2; pfam12802 366394003918 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394003919 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 366394003920 putative ADP-binding pocket [chemical binding]; other site 366394003921 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 366394003922 active site 366394003923 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394003924 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 366394003925 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 366394003926 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 366394003927 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 366394003928 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 366394003929 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 366394003930 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 366394003931 substrate binding site; other site 366394003932 tetramer interface; other site 366394003933 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 366394003934 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 366394003935 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 366394003936 NAD binding site [chemical binding]; other site 366394003937 substrate binding site [chemical binding]; other site 366394003938 homodimer interface [polypeptide binding]; other site 366394003939 active site 366394003940 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 366394003941 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 366394003942 NADP binding site [chemical binding]; other site 366394003943 active site 366394003944 putative substrate binding site [chemical binding]; other site 366394003945 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 366394003946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 366394003947 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 366394003948 Domain of unknown function DUF20; Region: UPF0118; pfam01594 366394003949 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 366394003950 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 366394003951 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394003952 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 366394003953 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394003954 catalytic loop [active] 366394003955 iron binding site [ion binding]; other site 366394003956 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 366394003957 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 366394003958 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 366394003959 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 366394003960 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 366394003961 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 366394003962 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 366394003963 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394003964 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394003965 TM-ABC transporter signature motif; other site 366394003966 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394003967 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394003968 TM-ABC transporter signature motif; other site 366394003969 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394003970 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394003971 Walker A/P-loop; other site 366394003972 ATP binding site [chemical binding]; other site 366394003973 Q-loop/lid; other site 366394003974 ABC transporter signature motif; other site 366394003975 Walker B; other site 366394003976 D-loop; other site 366394003977 H-loop/switch region; other site 366394003978 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394003979 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394003980 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 366394003981 putative ligand binding site [chemical binding]; other site 366394003982 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394003983 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394003984 DNA binding site [nucleotide binding] 366394003985 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 366394003986 putative dimerization interface [polypeptide binding]; other site 366394003987 putative ligand binding site [chemical binding]; other site 366394003988 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 366394003989 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 366394003990 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 366394003991 NADP binding site [chemical binding]; other site 366394003992 homodimer interface [polypeptide binding]; other site 366394003993 active site 366394003994 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 366394003995 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394003996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394003997 DNA-binding site [nucleotide binding]; DNA binding site 366394003998 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 366394003999 DctM-like transporters; Region: DctM; pfam06808 366394004000 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 366394004001 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 366394004002 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 366394004003 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 366394004004 glucuronate isomerase; Reviewed; Region: PRK02925 366394004005 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 366394004006 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394004007 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394004008 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394004009 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 366394004010 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 366394004011 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 366394004012 Predicted membrane protein [Function unknown]; Region: COG2323 366394004013 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 366394004014 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 366394004015 Predicted membrane protein [Function unknown]; Region: COG4244 366394004016 Predicted membrane protein [Function unknown]; Region: COG3336 366394004017 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 366394004018 Cytochrome c553 [Energy production and conversion]; Region: COG2863 366394004019 Cytochrome c; Region: Cytochrom_C; cl11414 366394004020 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 366394004021 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 366394004022 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 366394004023 Cytochrome c; Region: Cytochrom_C; pfam00034 366394004024 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 366394004025 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 366394004026 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 366394004027 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 366394004028 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 366394004029 D-pathway; other site 366394004030 Low-spin heme binding site [chemical binding]; other site 366394004031 Putative water exit pathway; other site 366394004032 Binuclear center (active site) [active] 366394004033 K-pathway; other site 366394004034 Putative proton exit pathway; other site 366394004035 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394004036 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394004037 DNA binding site [nucleotide binding] 366394004038 domain linker motif; other site 366394004039 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 366394004040 dimerization interface [polypeptide binding]; other site 366394004041 ligand binding site [chemical binding]; other site 366394004042 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 366394004043 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 366394004044 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 366394004045 substrate binding site [chemical binding]; other site 366394004046 ATP binding site [chemical binding]; other site 366394004047 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394004048 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394004049 TM-ABC transporter signature motif; other site 366394004050 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394004051 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394004052 Walker A/P-loop; other site 366394004053 ATP binding site [chemical binding]; other site 366394004054 Q-loop/lid; other site 366394004055 ABC transporter signature motif; other site 366394004056 Walker B; other site 366394004057 D-loop; other site 366394004058 H-loop/switch region; other site 366394004059 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394004060 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 366394004061 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394004062 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394004063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 366394004064 peptide chain release factor 1; Provisional; Region: PRK04011 366394004065 Predicted chitinase [General function prediction only]; Region: COG3179 366394004066 catalytic residue [active] 366394004067 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394004068 BA14K-like protein; Region: BA14K; pfam07886 366394004069 Transposase; Region: HTH_Tnp_1; pfam01527 366394004070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 366394004071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394004072 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 366394004073 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 366394004074 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 366394004075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394004076 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 366394004077 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 366394004078 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 366394004079 Chain length determinant protein; Region: Wzz; cl15801 366394004080 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 366394004081 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 366394004082 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 366394004083 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 366394004084 Probable Catalytic site; other site 366394004085 metal-binding site 366394004086 Homeodomain-like domain; Region: HTH_23; pfam13384 366394004087 Winged helix-turn helix; Region: HTH_29; pfam13551 366394004088 Homeodomain-like domain; Region: HTH_32; pfam13565 366394004089 DDE superfamily endonuclease; Region: DDE_3; pfam13358 366394004090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 366394004091 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 366394004092 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 366394004093 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 366394004094 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 366394004095 DXD motif; other site 366394004096 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 366394004097 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 366394004098 Substrate binding site; other site 366394004099 Cupin domain; Region: Cupin_2; cl17218 366394004100 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 366394004101 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 366394004102 active site 366394004103 substrate binding site [chemical binding]; other site 366394004104 metal binding site [ion binding]; metal-binding site 366394004105 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 366394004106 Bacterial sugar transferase; Region: Bac_transf; pfam02397 366394004107 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394004108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 366394004109 active site 366394004110 dimerization interface [polypeptide binding]; other site 366394004111 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394004112 DNA binding residues [nucleotide binding] 366394004113 dimerization interface [polypeptide binding]; other site 366394004114 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 366394004115 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 366394004116 active site 366394004117 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747 366394004118 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 366394004119 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 366394004120 putative trimer interface [polypeptide binding]; other site 366394004121 putative active site [active] 366394004122 putative substrate binding site [chemical binding]; other site 366394004123 putative CoA binding site [chemical binding]; other site 366394004124 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394004125 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394004126 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394004127 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 366394004128 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 366394004129 inhibitor-cofactor binding pocket; inhibition site 366394004130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394004131 catalytic residue [active] 366394004132 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 366394004133 putative trimer interface [polypeptide binding]; other site 366394004134 putative CoA binding site [chemical binding]; other site 366394004135 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394004136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394004137 NAD(P) binding site [chemical binding]; other site 366394004138 active site 366394004139 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 366394004140 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 366394004141 inhibitor-cofactor binding pocket; inhibition site 366394004142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394004143 catalytic residue [active] 366394004144 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 366394004145 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 366394004146 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 366394004147 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 366394004148 NADP binding site [chemical binding]; other site 366394004149 active site 366394004150 putative substrate binding site [chemical binding]; other site 366394004151 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 366394004152 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 366394004153 NAD binding site [chemical binding]; other site 366394004154 substrate binding site [chemical binding]; other site 366394004155 homodimer interface [polypeptide binding]; other site 366394004156 active site 366394004157 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 366394004158 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 366394004159 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 366394004160 substrate binding site; other site 366394004161 tetramer interface; other site 366394004162 SLBB domain; Region: SLBB; pfam10531 366394004163 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394004164 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394004165 DNA binding residues [nucleotide binding] 366394004166 dimerization interface [polypeptide binding]; other site 366394004167 Hint domain; Region: Hint_2; pfam13403 366394004168 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 366394004169 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 366394004170 ligand binding site [chemical binding]; other site 366394004171 flexible hinge region; other site 366394004172 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 366394004173 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394004174 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394004175 DNA binding residues [nucleotide binding] 366394004176 dimerization interface [polypeptide binding]; other site 366394004177 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 366394004178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394004179 active site 366394004180 phosphorylation site [posttranslational modification] 366394004181 intermolecular recognition site; other site 366394004182 dimerization interface [polypeptide binding]; other site 366394004183 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 366394004184 active site 366394004185 DNA binding site [nucleotide binding] 366394004186 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 366394004187 Predicted small integral membrane protein [Function unknown]; Region: COG5478 366394004188 GcrA cell cycle regulator; Region: GcrA; cl11564 366394004189 acyl carrier protein; Provisional; Region: acpP; PRK00982 366394004190 Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353 366394004191 Predicted membrane protein [Function unknown]; Region: COG2261 366394004192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 366394004193 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 366394004194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394004195 DNA-binding site [nucleotide binding]; DNA binding site 366394004196 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394004197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394004198 homodimer interface [polypeptide binding]; other site 366394004199 catalytic residue [active] 366394004200 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 366394004201 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394004202 substrate binding pocket [chemical binding]; other site 366394004203 membrane-bound complex binding site; other site 366394004204 hinge residues; other site 366394004205 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 366394004206 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 366394004207 Walker A/P-loop; other site 366394004208 ATP binding site [chemical binding]; other site 366394004209 Q-loop/lid; other site 366394004210 ABC transporter signature motif; other site 366394004211 Walker B; other site 366394004212 D-loop; other site 366394004213 H-loop/switch region; other site 366394004214 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 366394004215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004216 dimer interface [polypeptide binding]; other site 366394004217 conserved gate region; other site 366394004218 putative PBP binding loops; other site 366394004219 ABC-ATPase subunit interface; other site 366394004220 SnoaL-like domain; Region: SnoaL_2; pfam12680 366394004221 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 366394004222 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394004223 Transcriptional regulator [Transcription]; Region: IclR; COG1414 366394004224 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394004225 putative Zn2+ binding site [ion binding]; other site 366394004226 putative DNA binding site [nucleotide binding]; other site 366394004227 Bacterial transcriptional regulator; Region: IclR; pfam01614 366394004228 choline dehydrogenase; Validated; Region: PRK02106 366394004229 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 366394004230 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 366394004231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394004232 metabolite-proton symporter; Region: 2A0106; TIGR00883 366394004233 putative substrate translocation pore; other site 366394004234 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 366394004235 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 366394004236 PYR/PP interface [polypeptide binding]; other site 366394004237 dimer interface [polypeptide binding]; other site 366394004238 TPP binding site [chemical binding]; other site 366394004239 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 366394004240 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 366394004241 TPP-binding site; other site 366394004242 Predicted membrane protein [Function unknown]; Region: COG2855 366394004243 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 366394004244 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 366394004245 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 366394004246 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 366394004247 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394004248 hydroxyglutarate oxidase; Provisional; Region: PRK11728 366394004249 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 366394004250 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 366394004251 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 366394004252 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 366394004253 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 366394004254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394004255 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 366394004256 dimerization interface [polypeptide binding]; other site 366394004257 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 366394004258 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 366394004259 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 366394004260 PhoU domain; Region: PhoU; pfam01895 366394004261 PhoU domain; Region: PhoU; pfam01895 366394004262 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 366394004263 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 366394004264 catalytic residue [active] 366394004265 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 366394004266 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 366394004267 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 366394004268 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 366394004269 NAD(P) binding site [chemical binding]; other site 366394004270 catalytic residues [active] 366394004271 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394004272 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 366394004273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394004274 Walker A/P-loop; other site 366394004275 ATP binding site [chemical binding]; other site 366394004276 Q-loop/lid; other site 366394004277 ABC transporter signature motif; other site 366394004278 Walker B; other site 366394004279 D-loop; other site 366394004280 H-loop/switch region; other site 366394004281 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 366394004282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004283 dimer interface [polypeptide binding]; other site 366394004284 conserved gate region; other site 366394004285 putative PBP binding loops; other site 366394004286 ABC-ATPase subunit interface; other site 366394004287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004288 dimer interface [polypeptide binding]; other site 366394004289 conserved gate region; other site 366394004290 putative PBP binding loops; other site 366394004291 ABC-ATPase subunit interface; other site 366394004292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 366394004293 Predicted integral membrane protein [Function unknown]; Region: COG5616 366394004294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 366394004295 TPR motif; other site 366394004296 binding surface 366394004297 Uncharacterized conserved protein [Function unknown]; Region: COG5361 366394004298 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 366394004299 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 366394004300 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 366394004301 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 366394004302 DNA-binding interface [nucleotide binding]; DNA binding site 366394004303 Homeodomain-like domain; Region: HTH_32; pfam13565 366394004304 Integrase core domain; Region: rve; pfam00665 366394004305 Helix-turn-helix domain; Region: HTH_28; pfam13518 366394004306 Winged helix-turn helix; Region: HTH_29; pfam13551 366394004307 Homeodomain-like domain; Region: HTH_32; pfam13565 366394004308 Integrase core domain; Region: rve; pfam00665 366394004309 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 366394004310 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 366394004311 putative active site [active] 366394004312 putative FMN binding site [chemical binding]; other site 366394004313 putative substrate binding site [chemical binding]; other site 366394004314 putative catalytic residue [active] 366394004315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 366394004316 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394004317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394004318 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 366394004319 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 366394004320 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 366394004321 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394004322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 366394004323 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394004324 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 366394004325 putative C-terminal domain interface [polypeptide binding]; other site 366394004326 putative GSH binding site (G-site) [chemical binding]; other site 366394004327 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394004328 putative dimer interface [polypeptide binding]; other site 366394004329 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 366394004330 dimer interface [polypeptide binding]; other site 366394004331 N-terminal domain interface [polypeptide binding]; other site 366394004332 putative substrate binding pocket (H-site) [chemical binding]; other site 366394004333 Major Facilitator Superfamily; Region: MFS_1; pfam07690 366394004334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394004335 putative substrate translocation pore; other site 366394004336 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394004337 dimerization interface [polypeptide binding]; other site 366394004338 putative DNA binding site [nucleotide binding]; other site 366394004339 putative Zn2+ binding site [ion binding]; other site 366394004340 Cupin domain; Region: Cupin_2; cl17218 366394004341 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394004342 cyclase homology domain; Region: CHD; cd07302 366394004343 nucleotidyl binding site; other site 366394004344 metal binding site [ion binding]; metal-binding site 366394004345 dimer interface [polypeptide binding]; other site 366394004346 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 366394004347 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 366394004348 metal-binding site [ion binding] 366394004349 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 366394004350 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 366394004351 metal-binding site [ion binding] 366394004352 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 366394004353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394004354 motif II; other site 366394004355 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 366394004356 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 366394004357 DNA binding residues [nucleotide binding] 366394004358 dimer interface [polypeptide binding]; other site 366394004359 copper binding site [ion binding]; other site 366394004360 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 366394004361 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394004362 putative ADP-binding pocket [chemical binding]; other site 366394004363 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 366394004364 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 366394004365 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 366394004366 putative active site [active] 366394004367 putative NTP binding site [chemical binding]; other site 366394004368 putative nucleic acid binding site [nucleotide binding]; other site 366394004369 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 366394004370 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 366394004371 glutathione synthetase; Provisional; Region: PRK12458 366394004372 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 366394004373 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 366394004374 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394004375 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 366394004376 putative ligand binding site [chemical binding]; other site 366394004377 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394004378 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394004379 Walker A/P-loop; other site 366394004380 ATP binding site [chemical binding]; other site 366394004381 Q-loop/lid; other site 366394004382 ABC transporter signature motif; other site 366394004383 Walker B; other site 366394004384 D-loop; other site 366394004385 H-loop/switch region; other site 366394004386 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394004387 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394004388 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394004389 TM-ABC transporter signature motif; other site 366394004390 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394004391 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394004392 TM-ABC transporter signature motif; other site 366394004393 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394004394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394004395 DNA-binding site [nucleotide binding]; DNA binding site 366394004396 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394004397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394004398 Walker A/P-loop; other site 366394004399 ATP binding site [chemical binding]; other site 366394004400 Q-loop/lid; other site 366394004401 ABC transporter signature motif; other site 366394004402 Walker B; other site 366394004403 D-loop; other site 366394004404 H-loop/switch region; other site 366394004405 TOBE domain; Region: TOBE_2; pfam08402 366394004406 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394004407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004408 dimer interface [polypeptide binding]; other site 366394004409 conserved gate region; other site 366394004410 ABC-ATPase subunit interface; other site 366394004411 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394004412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004413 dimer interface [polypeptide binding]; other site 366394004414 conserved gate region; other site 366394004415 putative PBP binding loops; other site 366394004416 ABC-ATPase subunit interface; other site 366394004417 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394004418 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394004419 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 366394004420 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394004421 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394004422 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394004423 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394004424 DNA binding site [nucleotide binding] 366394004425 domain linker motif; other site 366394004426 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 366394004427 ligand binding site [chemical binding]; other site 366394004428 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 366394004429 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 366394004430 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 366394004431 Peptidase family M50; Region: Peptidase_M50; pfam02163 366394004432 active site 366394004433 putative substrate binding region [chemical binding]; other site 366394004434 FOG: CBS domain [General function prediction only]; Region: COG0517 366394004435 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 366394004436 Domain of unknown function (DUF305); Region: DUF305; cl17794 366394004437 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 366394004438 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 366394004439 protein binding site [polypeptide binding]; other site 366394004440 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 366394004441 Active site serine [active] 366394004442 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394004443 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394004444 TM-ABC transporter signature motif; other site 366394004445 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 366394004446 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394004447 Walker A/P-loop; other site 366394004448 ATP binding site [chemical binding]; other site 366394004449 Q-loop/lid; other site 366394004450 ABC transporter signature motif; other site 366394004451 Walker B; other site 366394004452 D-loop; other site 366394004453 H-loop/switch region; other site 366394004454 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 366394004455 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 366394004456 ligand binding site [chemical binding]; other site 366394004457 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 366394004458 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 366394004459 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 366394004460 active site 366394004461 catalytic residues [active] 366394004462 PAS domain; Region: PAS_9; pfam13426 366394004463 PAS domain S-box; Region: sensory_box; TIGR00229 366394004464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394004465 putative active site [active] 366394004466 heme pocket [chemical binding]; other site 366394004467 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 366394004468 GAF domain; Region: GAF; pfam01590 366394004469 PAS domain; Region: PAS_9; pfam13426 366394004470 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 366394004471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394004472 PAS fold; Region: PAS_3; pfam08447 366394004473 putative active site [active] 366394004474 heme pocket [chemical binding]; other site 366394004475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 366394004476 HWE histidine kinase; Region: HWE_HK; pfam07536 366394004477 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 366394004478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394004479 active site 366394004480 phosphorylation site [posttranslational modification] 366394004481 intermolecular recognition site; other site 366394004482 dimerization interface [polypeptide binding]; other site 366394004483 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394004484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394004485 non-specific DNA binding site [nucleotide binding]; other site 366394004486 salt bridge; other site 366394004487 sequence-specific DNA binding site [nucleotide binding]; other site 366394004488 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 366394004489 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 366394004490 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 366394004491 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 366394004492 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 366394004493 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 366394004494 active site 366394004495 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 366394004496 Ligand Binding Site [chemical binding]; other site 366394004497 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 366394004498 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 366394004499 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 366394004500 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 366394004501 Walker A/P-loop; other site 366394004502 ATP binding site [chemical binding]; other site 366394004503 Q-loop/lid; other site 366394004504 ABC transporter signature motif; other site 366394004505 Walker B; other site 366394004506 D-loop; other site 366394004507 H-loop/switch region; other site 366394004508 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 366394004509 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 366394004510 NAD binding site [chemical binding]; other site 366394004511 homodimer interface [polypeptide binding]; other site 366394004512 active site 366394004513 substrate binding site [chemical binding]; other site 366394004514 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 366394004515 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 366394004516 O-Antigen ligase; Region: Wzy_C; pfam04932 366394004517 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 366394004518 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 366394004519 SLBB domain; Region: SLBB; pfam10531 366394004520 Bacterial sugar transferase; Region: Bac_transf; pfam02397 366394004521 Exopolysaccharide production repressor; Region: SyrA; pfam11089 366394004522 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 366394004523 active site 366394004524 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 366394004525 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 366394004526 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 366394004527 active site 366394004528 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 366394004529 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 366394004530 Acyltransferase family; Region: Acyl_transf_3; pfam01757 366394004531 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 366394004532 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 366394004533 active site 366394004534 active site 366394004535 catalytic residues [active] 366394004536 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 366394004537 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 366394004538 Ligand binding site; other site 366394004539 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 366394004540 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 366394004541 active site 366394004542 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 366394004543 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 366394004544 active site 366394004545 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 366394004546 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 366394004547 active site 366394004548 tetramer interface; other site 366394004549 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 366394004550 Chain length determinant protein; Region: Wzz; pfam02706 366394004551 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 366394004552 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 366394004553 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 366394004554 dimer interface [polypeptide binding]; other site 366394004555 substrate binding site [chemical binding]; other site 366394004556 ATP binding site [chemical binding]; other site 366394004557 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 366394004558 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 366394004559 dimer interface [polypeptide binding]; other site 366394004560 decamer (pentamer of dimers) interface [polypeptide binding]; other site 366394004561 catalytic triad [active] 366394004562 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 366394004563 Beta-lactamase; Region: Beta-lactamase; pfam00144 366394004564 Acyl dehydratase [Lipid metabolism]; Region: MaoC; COG2030 366394004565 active site 2 [active] 366394004566 active site 1 [active] 366394004567 DctM-like transporters; Region: DctM; pfam06808 366394004568 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 366394004569 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 366394004570 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 366394004571 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 366394004572 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 366394004573 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 366394004574 putative active site pocket [active] 366394004575 metal binding site [ion binding]; metal-binding site 366394004576 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 366394004577 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 366394004578 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394004579 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 366394004580 NAD binding site [chemical binding]; other site 366394004581 homotetramer interface [polypeptide binding]; other site 366394004582 homodimer interface [polypeptide binding]; other site 366394004583 active site 366394004584 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 366394004585 active site 2 [active] 366394004586 active site 1 [active] 366394004587 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394004588 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394004589 Uncharacterized conserved protein [Function unknown]; Region: COG3254 366394004590 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 366394004591 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 366394004592 active site pocket [active] 366394004593 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394004594 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394004595 Walker A/P-loop; other site 366394004596 ATP binding site [chemical binding]; other site 366394004597 Q-loop/lid; other site 366394004598 ABC transporter signature motif; other site 366394004599 Walker B; other site 366394004600 D-loop; other site 366394004601 H-loop/switch region; other site 366394004602 TOBE domain; Region: TOBE_2; pfam08402 366394004603 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394004604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004605 dimer interface [polypeptide binding]; other site 366394004606 conserved gate region; other site 366394004607 putative PBP binding loops; other site 366394004608 ABC-ATPase subunit interface; other site 366394004609 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394004610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004611 dimer interface [polypeptide binding]; other site 366394004612 conserved gate region; other site 366394004613 putative PBP binding loops; other site 366394004614 ABC-ATPase subunit interface; other site 366394004615 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394004616 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394004617 Transcriptional regulator [Transcription]; Region: IclR; COG1414 366394004618 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 366394004619 Bacterial transcriptional regulator; Region: IclR; pfam01614 366394004620 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 366394004621 Amidohydrolase; Region: Amidohydro_2; pfam04909 366394004622 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 366394004623 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 366394004624 active site 366394004625 catalytic site [active] 366394004626 Zn binding site [ion binding]; other site 366394004627 tetramer interface [polypeptide binding]; other site 366394004628 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 366394004629 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394004630 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 366394004631 substrate binding pocket [chemical binding]; other site 366394004632 membrane-bound complex binding site; other site 366394004633 hinge residues; other site 366394004634 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 366394004635 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 366394004636 Walker A/P-loop; other site 366394004637 ATP binding site [chemical binding]; other site 366394004638 Q-loop/lid; other site 366394004639 ABC transporter signature motif; other site 366394004640 Walker B; other site 366394004641 D-loop; other site 366394004642 H-loop/switch region; other site 366394004643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004644 dimer interface [polypeptide binding]; other site 366394004645 conserved gate region; other site 366394004646 putative PBP binding loops; other site 366394004647 ABC-ATPase subunit interface; other site 366394004648 argininosuccinate lyase; Provisional; Region: PRK00855 366394004649 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 366394004650 active sites [active] 366394004651 tetramer interface [polypeptide binding]; other site 366394004652 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 366394004653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394004654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394004655 dimerization interface [polypeptide binding]; other site 366394004656 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394004657 Coenzyme A binding pocket [chemical binding]; other site 366394004658 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 366394004659 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 366394004660 active site 366394004661 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394004662 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 366394004663 CoA-transferase family III; Region: CoA_transf_3; pfam02515 366394004664 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 366394004665 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 366394004666 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 366394004667 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 366394004668 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 366394004669 Walker A/P-loop; other site 366394004670 ATP binding site [chemical binding]; other site 366394004671 Q-loop/lid; other site 366394004672 ABC transporter signature motif; other site 366394004673 Walker B; other site 366394004674 D-loop; other site 366394004675 H-loop/switch region; other site 366394004676 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 366394004677 KpsF/GutQ family protein; Region: kpsF; TIGR00393 366394004678 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 366394004679 putative active site [active] 366394004680 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 366394004681 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 366394004682 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 366394004683 NAD binding site [chemical binding]; other site 366394004684 homodimer interface [polypeptide binding]; other site 366394004685 active site 366394004686 substrate binding site [chemical binding]; other site 366394004687 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 366394004688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394004689 S-adenosylmethionine binding site [chemical binding]; other site 366394004690 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 366394004691 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 366394004692 active site 366394004693 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 366394004694 TPR repeat; Region: TPR_11; pfam13414 366394004695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394004696 TPR motif; other site 366394004697 binding surface 366394004698 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 366394004699 ABC-2 type transporter; Region: ABC2_membrane; cl17235 366394004700 Ketopantoate hydroxymethyltransferase [Coenzyme metabolism]; Region: PanB; COG0413 366394004701 oligomerization interface [polypeptide binding]; other site 366394004702 active site 366394004703 metal binding site [ion binding]; metal-binding site 366394004704 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 366394004705 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394004706 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 366394004707 [2Fe-2S] cluster binding site [ion binding]; other site 366394004708 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 366394004709 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 366394004710 putative di-iron ligands [ion binding]; other site 366394004711 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394004712 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394004713 DNA binding site [nucleotide binding] 366394004714 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 366394004715 putative ligand binding site [chemical binding]; other site 366394004716 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 366394004717 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 366394004718 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 366394004719 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 366394004720 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 366394004721 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 366394004722 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 366394004723 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 366394004724 Walker A/P-loop; other site 366394004725 ATP binding site [chemical binding]; other site 366394004726 Q-loop/lid; other site 366394004727 ABC transporter signature motif; other site 366394004728 Walker B; other site 366394004729 D-loop; other site 366394004730 H-loop/switch region; other site 366394004731 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 366394004732 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 366394004733 KpsF/GutQ family protein; Region: kpsF; TIGR00393 366394004734 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 366394004735 putative active site [active] 366394004736 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 366394004737 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 366394004738 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 366394004739 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 366394004740 active site 366394004741 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 366394004742 Glycosyltransferase family 92; Region: Glyco_transf_92; pfam01697 366394004743 active site 366394004744 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 366394004745 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 366394004746 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 366394004747 metal-binding site [ion binding] 366394004748 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 366394004749 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 366394004750 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 366394004751 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 366394004752 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 366394004753 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 366394004754 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 366394004755 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394004756 sequence-specific DNA binding site [nucleotide binding]; other site 366394004757 salt bridge; other site 366394004758 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394004759 non-specific DNA binding site [nucleotide binding]; other site 366394004760 salt bridge; other site 366394004761 sequence-specific DNA binding site [nucleotide binding]; other site 366394004762 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394004763 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 366394004764 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394004765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004766 dimer interface [polypeptide binding]; other site 366394004767 conserved gate region; other site 366394004768 putative PBP binding loops; other site 366394004769 ABC-ATPase subunit interface; other site 366394004770 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 366394004771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004772 dimer interface [polypeptide binding]; other site 366394004773 conserved gate region; other site 366394004774 putative PBP binding loops; other site 366394004775 ABC-ATPase subunit interface; other site 366394004776 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 366394004777 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394004778 Walker A/P-loop; other site 366394004779 ATP binding site [chemical binding]; other site 366394004780 Q-loop/lid; other site 366394004781 ABC transporter signature motif; other site 366394004782 Walker B; other site 366394004783 D-loop; other site 366394004784 H-loop/switch region; other site 366394004785 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394004786 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394004787 Walker A/P-loop; other site 366394004788 ATP binding site [chemical binding]; other site 366394004789 Q-loop/lid; other site 366394004790 ABC transporter signature motif; other site 366394004791 Walker B; other site 366394004792 D-loop; other site 366394004793 H-loop/switch region; other site 366394004794 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 366394004795 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 366394004796 putative active site [active] 366394004797 putative metal binding site [ion binding]; other site 366394004798 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; pfam09587 366394004799 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 366394004800 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 366394004801 metal binding site [ion binding]; metal-binding site 366394004802 dimer interface [polypeptide binding]; other site 366394004803 Protein of unknown function (DUF736); Region: DUF736; pfam05284 366394004804 Protein of unknown function (DUF736); Region: DUF736; pfam05284 366394004805 Protein of unknown function (DUF736); Region: DUF736; pfam05284 366394004806 Integrase core domain; Region: rve; pfam00665 366394004807 conjugal transfer protein TraD; Provisional; Region: PRK13847 366394004808 conjugal transfer protein TraC; Provisional; Region: PRK13848 366394004809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 366394004810 DDE superfamily endonuclease; Region: DDE_3; pfam13358 366394004811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 366394004812 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 366394004813 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 366394004814 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 366394004815 arsenical-resistance protein; Region: acr3; TIGR00832 366394004816 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 366394004817 ArsC family; Region: ArsC; pfam03960 366394004818 catalytic residues [active] 366394004819 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 366394004820 Low molecular weight phosphatase family; Region: LMWPc; cd00115 366394004821 active site 366394004822 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394004823 dimerization interface [polypeptide binding]; other site 366394004824 putative DNA binding site [nucleotide binding]; other site 366394004825 putative Zn2+ binding site [ion binding]; other site 366394004826 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 366394004827 RibD C-terminal domain; Region: RibD_C; cl17279 366394004828 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 366394004829 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 366394004830 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 366394004831 TAP-like protein; Region: Abhydrolase_4; pfam08386 366394004832 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 366394004833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394004834 NAD(P) binding site [chemical binding]; other site 366394004835 active site 366394004836 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 366394004837 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 366394004838 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394004839 Walker A/P-loop; other site 366394004840 ATP binding site [chemical binding]; other site 366394004841 Q-loop/lid; other site 366394004842 ABC transporter signature motif; other site 366394004843 Walker B; other site 366394004844 D-loop; other site 366394004845 H-loop/switch region; other site 366394004846 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 366394004847 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 366394004848 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394004849 Walker A/P-loop; other site 366394004850 ATP binding site [chemical binding]; other site 366394004851 Q-loop/lid; other site 366394004852 ABC transporter signature motif; other site 366394004853 Walker B; other site 366394004854 D-loop; other site 366394004855 H-loop/switch region; other site 366394004856 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394004857 dipeptide transporter; Provisional; Region: PRK10913 366394004858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004859 dimer interface [polypeptide binding]; other site 366394004860 conserved gate region; other site 366394004861 putative PBP binding loops; other site 366394004862 ABC-ATPase subunit interface; other site 366394004863 nickel transporter permease NikB; Provisional; Region: PRK10352 366394004864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004865 dimer interface [polypeptide binding]; other site 366394004866 conserved gate region; other site 366394004867 putative PBP binding loops; other site 366394004868 ABC-ATPase subunit interface; other site 366394004869 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394004870 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 366394004871 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 366394004872 Amidase; Region: Amidase; pfam01425 366394004873 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394004874 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 366394004875 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 366394004876 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 366394004877 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 366394004878 catalytic loop [active] 366394004879 iron binding site [ion binding]; other site 366394004880 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394004881 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 366394004882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394004883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394004884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 366394004885 dimerization interface [polypeptide binding]; other site 366394004886 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394004887 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394004888 putative DNA binding site [nucleotide binding]; other site 366394004889 putative Zn2+ binding site [ion binding]; other site 366394004890 AsnC family; Region: AsnC_trans_reg; pfam01037 366394004891 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 366394004892 catalytic residue [active] 366394004893 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 366394004894 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394004895 Walker A/P-loop; other site 366394004896 ATP binding site [chemical binding]; other site 366394004897 Q-loop/lid; other site 366394004898 ABC transporter signature motif; other site 366394004899 Walker B; other site 366394004900 D-loop; other site 366394004901 H-loop/switch region; other site 366394004902 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 366394004903 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394004904 Walker A/P-loop; other site 366394004905 ATP binding site [chemical binding]; other site 366394004906 Q-loop/lid; other site 366394004907 ABC transporter signature motif; other site 366394004908 Walker B; other site 366394004909 D-loop; other site 366394004910 H-loop/switch region; other site 366394004911 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394004912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 366394004913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004914 dimer interface [polypeptide binding]; other site 366394004915 conserved gate region; other site 366394004916 putative PBP binding loops; other site 366394004917 ABC-ATPase subunit interface; other site 366394004918 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394004919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004920 dimer interface [polypeptide binding]; other site 366394004921 conserved gate region; other site 366394004922 putative PBP binding loops; other site 366394004923 ABC-ATPase subunit interface; other site 366394004924 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394004925 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 366394004926 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 366394004927 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 366394004928 putative active site [active] 366394004929 catalytic residue [active] 366394004930 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394004931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394004932 DNA-binding site [nucleotide binding]; DNA binding site 366394004933 FCD domain; Region: FCD; pfam07729 366394004934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394004935 Major Facilitator Superfamily; Region: MFS_1; pfam07690 366394004936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394004937 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 366394004938 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 366394004939 substrate binding site [chemical binding]; other site 366394004940 oxyanion hole (OAH) forming residues; other site 366394004941 trimer interface [polypeptide binding]; other site 366394004942 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 366394004943 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 366394004944 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 366394004945 Walker A; other site 366394004946 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 366394004947 B12 binding site [chemical binding]; other site 366394004948 cobalt ligand [ion binding]; other site 366394004949 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 366394004950 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 366394004951 inhibitor-cofactor binding pocket; inhibition site 366394004952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394004953 catalytic residue [active] 366394004954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394004955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394004956 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 366394004957 putative dimerization interface [polypeptide binding]; other site 366394004958 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 366394004959 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 366394004960 Bacterial transcriptional regulator; Region: IclR; pfam01614 366394004961 Coenzyme A transferase; Region: CoA_trans; cl17247 366394004962 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 366394004963 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 366394004964 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 366394004965 dimer interface [polypeptide binding]; other site 366394004966 active site 366394004967 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 366394004968 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 366394004969 dimer interface [polypeptide binding]; other site 366394004970 active site 366394004971 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 366394004972 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 366394004973 NAD binding site [chemical binding]; other site 366394004974 homodimer interface [polypeptide binding]; other site 366394004975 homotetramer interface [polypeptide binding]; other site 366394004976 active site 366394004977 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 366394004978 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 366394004979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394004980 Uncharacterized conserved protein [Function unknown]; Region: COG5654 366394004981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 366394004982 sequence-specific DNA binding site [nucleotide binding]; other site 366394004983 salt bridge; other site 366394004984 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 366394004985 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 366394004986 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 366394004987 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 366394004988 active site pocket [active] 366394004989 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 366394004990 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 366394004991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394004992 dimer interface [polypeptide binding]; other site 366394004993 conserved gate region; other site 366394004994 putative PBP binding loops; other site 366394004995 ABC-ATPase subunit interface; other site 366394004996 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 366394004997 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 366394004998 Walker A/P-loop; other site 366394004999 ATP binding site [chemical binding]; other site 366394005000 Q-loop/lid; other site 366394005001 ABC transporter signature motif; other site 366394005002 Walker B; other site 366394005003 D-loop; other site 366394005004 H-loop/switch region; other site 366394005005 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 366394005006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394005007 dimer interface [polypeptide binding]; other site 366394005008 conserved gate region; other site 366394005009 ABC-ATPase subunit interface; other site 366394005010 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 366394005011 Isochorismatase family; Region: Isochorismatase; pfam00857 366394005012 catalytic triad [active] 366394005013 conserved cis-peptide bond; other site 366394005014 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 366394005015 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 366394005016 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 366394005017 active site 366394005018 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 366394005019 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 366394005020 conserved cys residue [active] 366394005021 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394005022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394005023 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 366394005024 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 366394005025 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394005026 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394005027 dimerization interface [polypeptide binding]; other site 366394005028 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394005029 hydroxyglutarate oxidase; Provisional; Region: PRK11728 366394005030 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 366394005031 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 366394005032 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 366394005033 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394005034 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 366394005035 putative active site [active] 366394005036 heme pocket [chemical binding]; other site 366394005037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394005038 putative active site [active] 366394005039 heme pocket [chemical binding]; other site 366394005040 PAS domain S-box; Region: sensory_box; TIGR00229 366394005041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394005042 putative active site [active] 366394005043 heme pocket [chemical binding]; other site 366394005044 PAS domain; Region: PAS_9; pfam13426 366394005045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394005046 putative active site [active] 366394005047 heme pocket [chemical binding]; other site 366394005048 RNase II stability modulator; Provisional; Region: PRK10060 366394005049 PAS domain; Region: PAS; smart00091 366394005050 putative active site [active] 366394005051 heme pocket [chemical binding]; other site 366394005052 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394005053 metal binding site [ion binding]; metal-binding site 366394005054 active site 366394005055 I-site; other site 366394005056 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 366394005057 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394005058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394005059 active site 366394005060 phosphorylation site [posttranslational modification] 366394005061 intermolecular recognition site; other site 366394005062 dimerization interface [polypeptide binding]; other site 366394005063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394005064 DNA binding residues [nucleotide binding] 366394005065 dimerization interface [polypeptide binding]; other site 366394005066 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 366394005067 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 366394005068 TPR repeat; Region: TPR_11; pfam13414 366394005069 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 366394005070 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 366394005071 dimerization interface [polypeptide binding]; other site 366394005072 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 366394005073 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 366394005074 dimer interface [polypeptide binding]; other site 366394005075 putative CheW interface [polypeptide binding]; other site 366394005076 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 366394005077 putative binding surface; other site 366394005078 active site 366394005079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394005080 ATP binding site [chemical binding]; other site 366394005081 Mg2+ binding site [ion binding]; other site 366394005082 G-X-G motif; other site 366394005083 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 366394005084 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 366394005085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394005086 active site 366394005087 phosphorylation site [posttranslational modification] 366394005088 intermolecular recognition site; other site 366394005089 dimerization interface [polypeptide binding]; other site 366394005090 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 366394005091 CheB methylesterase; Region: CheB_methylest; pfam01339 366394005092 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 366394005093 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 366394005094 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 366394005095 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 366394005096 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 366394005097 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 366394005098 ATP binding site [chemical binding]; other site 366394005099 Walker A motif; other site 366394005100 hexamer interface [polypeptide binding]; other site 366394005101 Walker B motif; other site 366394005102 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 366394005103 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 366394005104 TadE-like protein; Region: TadE; pfam07811 366394005105 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 366394005106 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 366394005107 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 366394005108 TadE-like protein; Region: TadE; pfam07811 366394005109 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 366394005110 Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177 366394005111 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 366394005112 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 366394005113 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 366394005114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394005115 binding surface 366394005116 Tetratricopeptide repeat; Region: TPR_16; pfam13432 366394005117 TPR motif; other site 366394005118 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 366394005119 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 366394005120 BON domain; Region: BON; pfam04972 366394005121 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 366394005122 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394005123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394005124 DNA-binding site [nucleotide binding]; DNA binding site 366394005125 FCD domain; Region: FCD; pfam07729 366394005126 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 366394005127 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 366394005128 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 366394005129 DctM-like transporters; Region: DctM; pfam06808 366394005130 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 366394005131 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 366394005132 malonyl-CoA synthase; Validated; Region: PRK07514 366394005133 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 366394005134 acyl-activating enzyme (AAE) consensus motif; other site 366394005135 active site 366394005136 AMP binding site [chemical binding]; other site 366394005137 CoA binding site [chemical binding]; other site 366394005138 transcription elongation factor regulatory protein; Validated; Region: PRK06342 366394005139 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 366394005140 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 366394005141 RNA polymerase sigma factor; Provisional; Region: PRK12547 366394005142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 366394005143 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 366394005144 DNA binding residues [nucleotide binding] 366394005145 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 366394005146 active site 366394005147 catalytic triad [active] 366394005148 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 366394005149 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 366394005150 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 366394005151 HSP70 interaction site [polypeptide binding]; other site 366394005152 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 366394005153 substrate binding site [polypeptide binding]; other site 366394005154 dimer interface [polypeptide binding]; other site 366394005155 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 366394005156 putative metal binding site [ion binding]; other site 366394005157 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 366394005158 putative catalytic site [active] 366394005159 putative phosphate binding site [ion binding]; other site 366394005160 putative metal binding site [ion binding]; other site 366394005161 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 366394005162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394005163 putative substrate translocation pore; other site 366394005164 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 366394005165 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 366394005166 putative hydrophobic ligand binding site [chemical binding]; other site 366394005167 Transposase domain (DUF772); Region: DUF772; pfam05598 366394005168 Uncharacterized conserved protein [Function unknown]; Region: COG5482 366394005169 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 366394005170 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394005171 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394005172 metal binding site [ion binding]; metal-binding site 366394005173 active site 366394005174 I-site; other site 366394005175 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 366394005176 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 366394005177 Domain of unknown function DUF20; Region: UPF0118; pfam01594 366394005178 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 366394005179 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 366394005180 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 366394005181 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 366394005182 Fatty acid desaturase; Region: FA_desaturase; pfam00487 366394005183 putative di-iron ligands [ion binding]; other site 366394005184 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 366394005185 DNA-binding site [nucleotide binding]; DNA binding site 366394005186 RNA-binding motif; other site 366394005187 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 366394005188 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394005189 Walker A/P-loop; other site 366394005190 ATP binding site [chemical binding]; other site 366394005191 Q-loop/lid; other site 366394005192 ABC transporter signature motif; other site 366394005193 Walker B; other site 366394005194 D-loop; other site 366394005195 H-loop/switch region; other site 366394005196 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394005197 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 366394005198 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394005199 Walker A/P-loop; other site 366394005200 ATP binding site [chemical binding]; other site 366394005201 Q-loop/lid; other site 366394005202 ABC transporter signature motif; other site 366394005203 Walker B; other site 366394005204 D-loop; other site 366394005205 H-loop/switch region; other site 366394005206 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394005207 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 366394005208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394005209 dimer interface [polypeptide binding]; other site 366394005210 conserved gate region; other site 366394005211 putative PBP binding loops; other site 366394005212 ABC-ATPase subunit interface; other site 366394005213 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394005214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394005215 dimer interface [polypeptide binding]; other site 366394005216 conserved gate region; other site 366394005217 putative PBP binding loops; other site 366394005218 ABC-ATPase subunit interface; other site 366394005219 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394005220 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 366394005221 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 366394005222 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 366394005223 active site 366394005224 cell density-dependent motility repressor; Provisional; Region: PRK10082 366394005225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394005226 LysR substrate binding domain; Region: LysR_substrate; pfam03466 366394005227 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 366394005228 homodimer interface [polypeptide binding]; other site 366394005229 homotetramer interface [polypeptide binding]; other site 366394005230 active site pocket [active] 366394005231 cleavage site 366394005232 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 366394005233 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 366394005234 homodimer interface [polypeptide binding]; other site 366394005235 substrate-cofactor binding pocket; other site 366394005236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394005237 catalytic residue [active] 366394005238 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 366394005239 MerR family regulatory protein; Region: MerR; pfam00376 366394005240 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 366394005241 P-loop; other site 366394005242 Magnesium ion binding site [ion binding]; other site 366394005243 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 366394005244 Magnesium ion binding site [ion binding]; other site 366394005245 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 366394005246 ParB-like nuclease domain; Region: ParB; smart00470 366394005247 replication initiation protein RepC; Provisional; Region: PRK13824 366394005248 Replication protein C N-terminal domain; Region: RP-C; pfam03428 366394005249 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 366394005250 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 366394005251 Periplasmic nitrate reductase system, NapE component [Energy production and conversion]; Region: NapE; COG4459 366394005252 ferredoxin-type protein; Provisional; Region: PRK10194 366394005253 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 366394005254 4Fe-4S binding domain; Region: Fer4; pfam00037 366394005255 NapD protein; Region: NapD; cl01163 366394005256 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 366394005257 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 366394005258 [4Fe-4S] binding site [ion binding]; other site 366394005259 molybdopterin cofactor binding site; other site 366394005260 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 366394005261 molybdopterin cofactor binding site; other site 366394005262 Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043 366394005263 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 366394005264 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 366394005265 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 366394005266 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 366394005267 ligand binding site [chemical binding]; other site 366394005268 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 366394005269 putative switch regulator; other site 366394005270 non-specific DNA interactions [nucleotide binding]; other site 366394005271 DNA binding site [nucleotide binding] 366394005272 sequence specific DNA binding site [nucleotide binding]; other site 366394005273 putative cAMP binding site [chemical binding]; other site 366394005274 Predicted integral membrane protein [Function unknown]; Region: COG5616 366394005275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394005276 TPR motif; other site 366394005277 binding surface 366394005278 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 366394005279 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 366394005280 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 366394005281 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 366394005282 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 366394005283 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 366394005284 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 366394005285 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394005286 substrate binding pocket [chemical binding]; other site 366394005287 membrane-bound complex binding site; other site 366394005288 hinge residues; other site 366394005289 putrescine transporter; Provisional; Region: potE; PRK10655 366394005290 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 366394005291 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 366394005292 ornithine decarboxylase; Provisional; Region: PRK13578 366394005293 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 366394005294 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 366394005295 catalytic residue [active] 366394005296 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 366394005297 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 366394005298 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 366394005299 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 366394005300 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 366394005301 catalytic residue [active] 366394005302 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 366394005303 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: COG3965 366394005304 arginine:agmatin antiporter; Provisional; Region: PRK10644 366394005305 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 366394005306 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 366394005307 arginine deiminase; Provisional; Region: PRK01388 366394005308 ornithine carbamoyltransferase; Validated; Region: PRK02102 366394005309 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 366394005310 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 366394005311 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 366394005312 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 366394005313 putative substrate binding site [chemical binding]; other site 366394005314 nucleotide binding site [chemical binding]; other site 366394005315 nucleotide binding site [chemical binding]; other site 366394005316 homodimer interface [polypeptide binding]; other site 366394005317 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 366394005318 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 366394005319 DXD motif; other site 366394005320 PilZ domain; Region: PilZ; pfam07238 366394005321 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 366394005322 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 366394005323 TCL1/MTCP1 family; Region: TCL1_MTCP1; pfam01840 366394005324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394005325 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 366394005326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394005327 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 366394005328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394005329 NAD(P) binding site [chemical binding]; other site 366394005330 active site 366394005331 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 366394005332 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 366394005333 Uncharacterized conserved protein [Function unknown]; Region: COG1359 366394005334 short chain dehydrogenase; Provisional; Region: PRK06180 366394005335 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 366394005336 NADP binding site [chemical binding]; other site 366394005337 active site 366394005338 steroid binding site; other site 366394005339 Predicted membrane protein [Function unknown]; Region: COG2259 366394005340 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 366394005341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394005342 NAD(P) binding site [chemical binding]; other site 366394005343 active site 366394005344 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 366394005345 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394005346 classical (c) SDRs; Region: SDR_c; cd05233 366394005347 NAD(P) binding site [chemical binding]; other site 366394005348 active site 366394005349 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 366394005350 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 366394005351 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 366394005352 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 366394005353 Pirin-related protein [General function prediction only]; Region: COG1741 366394005354 Pirin; Region: Pirin; pfam02678 366394005355 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 366394005356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394005357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394005358 LysR substrate binding domain; Region: LysR_substrate; pfam03466 366394005359 dimerization interface [polypeptide binding]; other site 366394005360 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 366394005361 Helix-turn-helix domain; Region: HTH_18; pfam12833 366394005362 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 366394005363 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 366394005364 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 366394005365 active site 366394005366 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 366394005367 Domain of unknown function DUF20; Region: UPF0118; pfam01594 366394005368 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 366394005369 TrkA-C domain; Region: TrkA_C; pfam02080 366394005370 TrkA-C domain; Region: TrkA_C; pfam02080 366394005371 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 366394005372 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 366394005373 peptidase T-like protein; Region: PepT-like; TIGR01883 366394005374 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 366394005375 metal binding site [ion binding]; metal-binding site 366394005376 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 366394005377 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 366394005378 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 366394005379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394005380 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394005381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394005382 DNA-binding site [nucleotide binding]; DNA binding site 366394005383 FCD domain; Region: FCD; pfam07729 366394005384 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 366394005385 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 366394005386 NAD(P) binding site [chemical binding]; other site 366394005387 catalytic residues [active] 366394005388 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 366394005389 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 366394005390 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394005391 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394005392 TM-ABC transporter signature motif; other site 366394005393 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 366394005394 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394005395 Walker A/P-loop; other site 366394005396 ATP binding site [chemical binding]; other site 366394005397 Q-loop/lid; other site 366394005398 ABC transporter signature motif; other site 366394005399 Walker B; other site 366394005400 D-loop; other site 366394005401 H-loop/switch region; other site 366394005402 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 366394005403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394005404 Coenzyme A binding pocket [chemical binding]; other site 366394005405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 366394005406 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 366394005407 active site 366394005408 Mn binding site [ion binding]; other site 366394005409 Ferritin-like domain; Region: Ferritin_2; pfam13668 366394005410 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 366394005411 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 366394005412 heme-binding site [chemical binding]; other site 366394005413 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 366394005414 FAD binding pocket [chemical binding]; other site 366394005415 FAD binding motif [chemical binding]; other site 366394005416 phosphate binding motif [ion binding]; other site 366394005417 beta-alpha-beta structure motif; other site 366394005418 NAD binding pocket [chemical binding]; other site 366394005419 Heme binding pocket [chemical binding]; other site 366394005420 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 366394005421 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 366394005422 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 366394005423 TIGR02588 family protein; Region: TIGR02588 366394005424 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 366394005425 Uncharacterized conserved protein [Function unknown]; Region: COG2135 366394005426 GXWXG protein; Region: GXWXG; pfam14231 366394005427 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 366394005428 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 366394005429 putative C-terminal domain interface [polypeptide binding]; other site 366394005430 putative GSH binding site (G-site) [chemical binding]; other site 366394005431 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394005432 putative dimer interface [polypeptide binding]; other site 366394005433 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 366394005434 N-terminal domain interface [polypeptide binding]; other site 366394005435 dimer interface [polypeptide binding]; other site 366394005436 substrate binding pocket (H-site) [chemical binding]; other site 366394005437 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 366394005438 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 366394005439 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 366394005440 tetramerization interface [polypeptide binding]; other site 366394005441 NAD(P) binding site [chemical binding]; other site 366394005442 catalytic residues [active] 366394005443 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 366394005444 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 366394005445 active site 366394005446 NAD binding site [chemical binding]; other site 366394005447 metal binding site [ion binding]; metal-binding site 366394005448 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 366394005449 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394005450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394005451 DNA-binding site [nucleotide binding]; DNA binding site 366394005452 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 366394005453 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394005454 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394005455 Walker A/P-loop; other site 366394005456 ATP binding site [chemical binding]; other site 366394005457 Q-loop/lid; other site 366394005458 ABC transporter signature motif; other site 366394005459 Walker B; other site 366394005460 D-loop; other site 366394005461 H-loop/switch region; other site 366394005462 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394005463 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394005464 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394005465 TM-ABC transporter signature motif; other site 366394005466 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394005467 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 366394005468 putative ligand binding site [chemical binding]; other site 366394005469 intracellular protease, PfpI family; Region: PfpI; TIGR01382 366394005470 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 366394005471 conserved cys residue [active] 366394005472 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 366394005473 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394005474 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 366394005475 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 366394005476 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 366394005477 active site 366394005478 catalytic site [active] 366394005479 substrate binding site [chemical binding]; other site 366394005480 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 366394005481 homotrimer interaction site [polypeptide binding]; other site 366394005482 putative active site [active] 366394005483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394005484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394005485 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 366394005486 putative effector binding pocket; other site 366394005487 putative dimerization interface [polypeptide binding]; other site 366394005488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394005489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394005490 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 366394005491 putative effector binding pocket; other site 366394005492 dimerization interface [polypeptide binding]; other site 366394005493 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 366394005494 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 366394005495 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 366394005496 active site 366394005497 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 366394005498 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 366394005499 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 366394005500 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 366394005501 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 366394005502 active site 366394005503 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 366394005504 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 366394005505 active site 366394005506 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 366394005507 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 366394005508 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 366394005509 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 366394005510 dimer interface [polypeptide binding]; other site 366394005511 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394005512 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 366394005513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394005514 NAD(P) binding site [chemical binding]; other site 366394005515 active site 366394005516 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394005517 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 366394005518 substrate binding pocket [chemical binding]; other site 366394005519 dimerization interface [polypeptide binding]; other site 366394005520 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 366394005521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 366394005522 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 366394005523 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 366394005524 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 366394005525 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 366394005526 active site 366394005527 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 366394005528 EamA-like transporter family; Region: EamA; pfam00892 366394005529 EamA-like transporter family; Region: EamA; pfam00892 366394005530 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394005531 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394005532 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394005533 dimerization interface [polypeptide binding]; other site 366394005534 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 366394005535 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 366394005536 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394005537 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394005538 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 366394005539 dimerization interface [polypeptide binding]; other site 366394005540 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394005541 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 366394005542 C-terminal domain interface [polypeptide binding]; other site 366394005543 GSH binding site (G-site) [chemical binding]; other site 366394005544 dimer interface [polypeptide binding]; other site 366394005545 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 366394005546 N-terminal domain interface [polypeptide binding]; other site 366394005547 dimer interface [polypeptide binding]; other site 366394005548 substrate binding pocket (H-site) [chemical binding]; other site 366394005549 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 366394005550 putative hydrophobic ligand binding site [chemical binding]; other site 366394005551 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394005552 dimerization interface [polypeptide binding]; other site 366394005553 putative DNA binding site [nucleotide binding]; other site 366394005554 putative Zn2+ binding site [ion binding]; other site 366394005555 short chain dehydrogenase; Provisional; Region: PRK06701 366394005556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394005557 NAD(P) binding site [chemical binding]; other site 366394005558 active site 366394005559 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 366394005560 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 366394005561 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 366394005562 Cupin domain; Region: Cupin_2; pfam07883 366394005563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394005564 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394005565 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394005566 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394005567 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394005568 active site 366394005569 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394005570 catalytic tetrad [active] 366394005571 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 366394005572 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 366394005573 catalytic residue [active] 366394005574 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 366394005575 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 366394005576 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394005577 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394005578 TM-ABC transporter signature motif; other site 366394005579 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394005580 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394005581 TM-ABC transporter signature motif; other site 366394005582 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394005583 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394005584 Walker A/P-loop; other site 366394005585 ATP binding site [chemical binding]; other site 366394005586 Q-loop/lid; other site 366394005587 ABC transporter signature motif; other site 366394005588 Walker B; other site 366394005589 D-loop; other site 366394005590 H-loop/switch region; other site 366394005591 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394005592 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394005593 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 366394005594 GAF domain; Region: GAF; cl17456 366394005595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 366394005596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394005597 ATP binding site [chemical binding]; other site 366394005598 Mg2+ binding site [ion binding]; other site 366394005599 G-X-G motif; other site 366394005600 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394005601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394005602 active site 366394005603 phosphorylation site [posttranslational modification] 366394005604 intermolecular recognition site; other site 366394005605 dimerization interface [polypeptide binding]; other site 366394005606 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 366394005607 DNA binding residues [nucleotide binding] 366394005608 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394005609 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394005610 metal binding site [ion binding]; metal-binding site 366394005611 active site 366394005612 I-site; other site 366394005613 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 366394005614 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 366394005615 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 366394005616 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 366394005617 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 366394005618 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 366394005619 catalytic residues [active] 366394005620 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394005621 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394005622 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 366394005623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394005624 Walker A/P-loop; other site 366394005625 ATP binding site [chemical binding]; other site 366394005626 Q-loop/lid; other site 366394005627 ABC transporter signature motif; other site 366394005628 Walker B; other site 366394005629 D-loop; other site 366394005630 H-loop/switch region; other site 366394005631 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 366394005632 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 366394005633 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 366394005634 NADP binding site [chemical binding]; other site 366394005635 dimer interface [polypeptide binding]; other site 366394005636 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394005637 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394005638 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 366394005639 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 366394005640 dimer interface [polypeptide binding]; other site 366394005641 active site 366394005642 heme binding site [chemical binding]; other site 366394005643 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 366394005644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394005645 cytosine deaminase; Validated; Region: PRK07572 366394005646 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 366394005647 active site 366394005648 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394005649 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 366394005650 TM-ABC transporter signature motif; other site 366394005651 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394005652 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 366394005653 TM-ABC transporter signature motif; other site 366394005654 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 366394005655 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394005656 Walker A/P-loop; other site 366394005657 ATP binding site [chemical binding]; other site 366394005658 Q-loop/lid; other site 366394005659 ABC transporter signature motif; other site 366394005660 Walker B; other site 366394005661 D-loop; other site 366394005662 H-loop/switch region; other site 366394005663 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394005664 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 366394005665 Amidase; Region: Amidase; cl11426 366394005666 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 366394005667 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 366394005668 putative ligand binding site [chemical binding]; other site 366394005669 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 366394005670 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 366394005671 inhibitor-cofactor binding pocket; inhibition site 366394005672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394005673 catalytic residue [active] 366394005674 Isochorismatase family; Region: Isochorismatase; pfam00857 366394005675 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 366394005676 catalytic triad [active] 366394005677 conserved cis-peptide bond; other site 366394005678 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 366394005679 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 366394005680 TM-ABC transporter signature motif; other site 366394005681 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 366394005682 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394005683 TM-ABC transporter signature motif; other site 366394005684 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 366394005685 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 366394005686 Walker A/P-loop; other site 366394005687 ATP binding site [chemical binding]; other site 366394005688 Q-loop/lid; other site 366394005689 ABC transporter signature motif; other site 366394005690 Walker B; other site 366394005691 D-loop; other site 366394005692 H-loop/switch region; other site 366394005693 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 366394005694 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 366394005695 Walker A/P-loop; other site 366394005696 ATP binding site [chemical binding]; other site 366394005697 Q-loop/lid; other site 366394005698 ABC transporter signature motif; other site 366394005699 Walker B; other site 366394005700 D-loop; other site 366394005701 H-loop/switch region; other site 366394005702 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 366394005703 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 366394005704 Isochorismatase family; Region: Isochorismatase; pfam00857 366394005705 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 366394005706 catalytic triad [active] 366394005707 conserved cis-peptide bond; other site 366394005708 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 366394005709 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 366394005710 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 366394005711 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 366394005712 putative active site [active] 366394005713 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 366394005714 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 366394005715 methionine sulfoxide reductase B; Provisional; Region: PRK00222 366394005716 SelR domain; Region: SelR; pfam01641 366394005717 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 366394005718 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394005719 cyclase homology domain; Region: CHD; cd07302 366394005720 nucleotidyl binding site; other site 366394005721 metal binding site [ion binding]; metal-binding site 366394005722 dimer interface [polypeptide binding]; other site 366394005723 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 366394005724 active site 366394005725 DNA polymerase IV; Validated; Region: PRK02406 366394005726 DNA binding site [nucleotide binding] 366394005727 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 366394005728 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 366394005729 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 366394005730 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 366394005731 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394005732 catalytic loop [active] 366394005733 iron binding site [ion binding]; other site 366394005734 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 366394005735 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 366394005736 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 366394005737 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 366394005738 Soluble P-type ATPase [General function prediction only]; Region: COG4087 366394005739 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 366394005740 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 366394005741 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 366394005742 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 366394005743 Ligand Binding Site [chemical binding]; other site 366394005744 GAF domain; Region: GAF_3; pfam13492 366394005745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394005746 dimer interface [polypeptide binding]; other site 366394005747 phosphorylation site [posttranslational modification] 366394005748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394005749 ATP binding site [chemical binding]; other site 366394005750 Mg2+ binding site [ion binding]; other site 366394005751 G-X-G motif; other site 366394005752 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 366394005753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394005754 active site 366394005755 phosphorylation site [posttranslational modification] 366394005756 intermolecular recognition site; other site 366394005757 dimerization interface [polypeptide binding]; other site 366394005758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394005759 DNA binding site [nucleotide binding] 366394005760 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 366394005761 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 366394005762 HPP family; Region: HPP; pfam04982 366394005763 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 366394005764 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 366394005765 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 366394005766 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 366394005767 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 366394005768 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 366394005769 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394005770 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394005771 dimerization interface [polypeptide binding]; other site 366394005772 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 366394005773 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 366394005774 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 366394005775 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394005776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394005777 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 366394005778 dimerization interface [polypeptide binding]; other site 366394005779 putative autoinducer synthesis protein; Provisional; Region: PRK13834 366394005780 conjugal transfer protein TrbB; Provisional; Region: PRK13833 366394005781 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 366394005782 ATP binding site [chemical binding]; other site 366394005783 Walker A motif; other site 366394005784 hexamer interface [polypeptide binding]; other site 366394005785 Walker B motif; other site 366394005786 conjugal transfer protein TrbC; Provisional; Region: PRK13871 366394005787 conjugal transfer protein TrbD; Provisional; Region: PRK13823 366394005788 conjugal transfer protein TrbE; Provisional; Region: PRK13830 366394005789 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 366394005790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394005791 Walker A/P-loop; other site 366394005792 ATP binding site [chemical binding]; other site 366394005793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394005794 Walker B; other site 366394005795 D-loop; other site 366394005796 H-loop/switch region; other site 366394005797 conjugal transfer protein TrbJ; Provisional; Region: PRK13842 366394005798 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 366394005799 Protein of unknown function (DUF2749); Region: DUF2749; pfam10907 366394005800 conjugal transfer protein TrbL; Provisional; Region: PRK13841 366394005801 conjugal transfer protein TrbF; Provisional; Region: PRK13836 366394005802 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 366394005803 VirB7 interaction site; other site 366394005804 conjugal transfer protein TrbH; Provisional; Region: PRK13835 366394005805 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 366394005806 conjugal transfer protein TrbI; Provisional; Region: PRK13831 366394005807 conjugal transfer protein TrbI; Provisional; Region: PRK13881 366394005808 transcriptional regulator TraR; Provisional; Region: PRK13870 366394005809 Autoinducer binding domain; Region: Autoind_bind; pfam03472 366394005810 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394005811 DNA binding residues [nucleotide binding] 366394005812 dimerization interface [polypeptide binding]; other site 366394005813 Prokaryotic Transcriptional repressor TraM; Region: Prok-TraM; pfam09228 366394005814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394005815 non-specific DNA binding site [nucleotide binding]; other site 366394005816 salt bridge; other site 366394005817 sequence-specific DNA binding site [nucleotide binding]; other site 366394005818 conjugal transfer protein TraB; Provisional; Region: PRK13825 366394005819 active site 366394005820 catalytic triad [active] 366394005821 dimer interface [polypeptide binding]; other site 366394005822 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 366394005823 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 366394005824 Dtr system oriT relaxase; Provisional; Region: PRK13826 366394005825 MobA/MobL family; Region: MobA_MobL; pfam03389 366394005826 AAA domain; Region: AAA_30; pfam13604 366394005827 Family description; Region: UvrD_C_2; pfam13538 366394005828 conjugal transfer protein TraC; Provisional; Region: PRK13848 366394005829 conjugal transfer protein TraD; Provisional; Region: PRK13847 366394005830 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 366394005831 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 366394005832 Walker A motif; other site 366394005833 ATP binding site [chemical binding]; other site 366394005834 Walker B motif; other site 366394005835 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 366394005836 Uncharacterized conserved protein [Function unknown]; Region: COG5489 366394005837 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394005838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394005839 non-specific DNA binding site [nucleotide binding]; other site 366394005840 salt bridge; other site 366394005841 sequence-specific DNA binding site [nucleotide binding]; other site 366394005842 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 366394005843 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 366394005844 Sulfate transporter family; Region: Sulfate_transp; pfam00916 366394005845 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 366394005846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 366394005847 non-specific DNA binding site [nucleotide binding]; other site 366394005848 salt bridge; other site 366394005849 sequence-specific DNA binding site [nucleotide binding]; other site 366394005850 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 366394005851 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 366394005852 active site 366394005853 Int/Topo IB signature motif; other site 366394005854 DNA binding site [nucleotide binding] 366394005855 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 366394005856 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 366394005857 active site 366394005858 DNA binding site [nucleotide binding] 366394005859 Int/Topo IB signature motif; other site 366394005860 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 366394005861 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 366394005862 Int/Topo IB signature motif; other site 366394005863 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 366394005864 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 366394005865 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 366394005866 metal binding site [ion binding]; metal-binding site 366394005867 dimer interface [polypeptide binding]; other site 366394005868 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 366394005869 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 366394005870 putative active site [active] 366394005871 putative metal binding site [ion binding]; other site 366394005872 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 366394005873 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394005874 Walker A/P-loop; other site 366394005875 ATP binding site [chemical binding]; other site 366394005876 Q-loop/lid; other site 366394005877 ABC transporter signature motif; other site 366394005878 Walker B; other site 366394005879 D-loop; other site 366394005880 H-loop/switch region; other site 366394005881 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 366394005882 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394005883 Walker A/P-loop; other site 366394005884 ATP binding site [chemical binding]; other site 366394005885 Q-loop/lid; other site 366394005886 ABC transporter signature motif; other site 366394005887 Walker B; other site 366394005888 D-loop; other site 366394005889 H-loop/switch region; other site 366394005890 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394005891 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 366394005892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394005893 dimer interface [polypeptide binding]; other site 366394005894 conserved gate region; other site 366394005895 putative PBP binding loops; other site 366394005896 ABC-ATPase subunit interface; other site 366394005897 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394005898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394005899 dimer interface [polypeptide binding]; other site 366394005900 conserved gate region; other site 366394005901 putative PBP binding loops; other site 366394005902 ABC-ATPase subunit interface; other site 366394005903 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394005904 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 366394005905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394005906 non-specific DNA binding site [nucleotide binding]; other site 366394005907 salt bridge; other site 366394005908 sequence-specific DNA binding site [nucleotide binding]; other site 366394005909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 366394005910 non-specific DNA binding site [nucleotide binding]; other site 366394005911 salt bridge; other site 366394005912 sequence-specific DNA binding site [nucleotide binding]; other site 366394005913 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 366394005914 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 366394005915 DNA-binding site [nucleotide binding]; DNA binding site 366394005916 RNA-binding motif; other site 366394005917 Uncharacterized conserved protein [Function unknown]; Region: COG5642 366394005918 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 366394005919 Uncharacterized conserved protein [Function unknown]; Region: COG5654 366394005920 HdeA/HdeB family; Region: HdeA; pfam06411 366394005921 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 366394005922 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 366394005923 active site 366394005924 DNA binding site [nucleotide binding] 366394005925 Int/Topo IB signature motif; other site 366394005926 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 366394005927 putative active site [active] 366394005928 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 366394005929 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 366394005930 DNA methylase; Region: N6_N4_Mtase; pfam01555 366394005931 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 366394005932 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 366394005933 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 366394005934 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 366394005935 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 366394005936 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 366394005937 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 366394005938 Predicted transcriptional regulator [Transcription]; Region: COG2378 366394005939 WYL domain; Region: WYL; pfam13280 366394005940 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 366394005941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 366394005942 DDE superfamily endonuclease; Region: DDE_3; pfam13358 366394005943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 366394005944 HNH endonuclease; Region: HNH_2; pfam13391 366394005945 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394005946 cyclase homology domain; Region: CHD; cd07302 366394005947 nucleotidyl binding site; other site 366394005948 metal binding site [ion binding]; metal-binding site 366394005949 dimer interface [polypeptide binding]; other site 366394005950 Predicted integral membrane protein [Function unknown]; Region: COG5616 366394005951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394005952 TPR motif; other site 366394005953 binding surface 366394005954 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 366394005955 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 366394005956 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 366394005957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 366394005958 Transposase; Region: DDE_Tnp_ISL3; pfam01610 366394005959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 366394005960 Transposase; Region: DDE_Tnp_ISL3; pfam01610 366394005961 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 366394005962 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 366394005963 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 366394005964 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 366394005965 substrate binding site [chemical binding]; other site 366394005966 ATP binding site [chemical binding]; other site 366394005967 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394005968 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394005969 DNA binding site [nucleotide binding] 366394005970 domain linker motif; other site 366394005971 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 366394005972 dimerization interface [polypeptide binding]; other site 366394005973 ligand binding site [chemical binding]; other site 366394005974 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394005975 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 366394005976 substrate binding pocket [chemical binding]; other site 366394005977 membrane-bound complex binding site; other site 366394005978 hinge residues; other site 366394005979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394005980 dimer interface [polypeptide binding]; other site 366394005981 conserved gate region; other site 366394005982 putative PBP binding loops; other site 366394005983 ABC-ATPase subunit interface; other site 366394005984 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 366394005985 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 366394005986 Walker A/P-loop; other site 366394005987 ATP binding site [chemical binding]; other site 366394005988 Q-loop/lid; other site 366394005989 ABC transporter signature motif; other site 366394005990 Walker B; other site 366394005991 D-loop; other site 366394005992 H-loop/switch region; other site 366394005993 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 366394005994 ornithine cyclodeaminase; Validated; Region: PRK06141 366394005995 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 366394005996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394005997 DNA-binding site [nucleotide binding]; DNA binding site 366394005998 UTRA domain; Region: UTRA; pfam07702 366394005999 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 366394006000 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 366394006001 putative active site [active] 366394006002 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 366394006003 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 366394006004 hydroxyglutarate oxidase; Provisional; Region: PRK11728 366394006005 fructoselysine 3-epimerase; Provisional; Region: PRK09856 366394006006 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 366394006007 Metal-binding active site; metal-binding site 366394006008 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 366394006009 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 366394006010 putative active site [active] 366394006011 putative FMN binding site [chemical binding]; other site 366394006012 putative catalytic residue [active] 366394006013 putative substrate binding site [chemical binding]; other site 366394006014 FCD domain; Region: FCD; cl11656 366394006015 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 366394006016 FAD binding domain; Region: FAD_binding_4; pfam01565 366394006017 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 366394006018 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394006019 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394006020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394006021 Walker A/P-loop; other site 366394006022 ATP binding site [chemical binding]; other site 366394006023 Q-loop/lid; other site 366394006024 ABC transporter signature motif; other site 366394006025 Walker B; other site 366394006026 D-loop; other site 366394006027 H-loop/switch region; other site 366394006028 TOBE domain; Region: TOBE_2; pfam08402 366394006029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394006030 dimer interface [polypeptide binding]; other site 366394006031 conserved gate region; other site 366394006032 putative PBP binding loops; other site 366394006033 ABC-ATPase subunit interface; other site 366394006034 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394006035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394006036 dimer interface [polypeptide binding]; other site 366394006037 conserved gate region; other site 366394006038 putative PBP binding loops; other site 366394006039 ABC-ATPase subunit interface; other site 366394006040 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 366394006041 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 366394006042 inhibitor site; inhibition site 366394006043 active site 366394006044 dimer interface [polypeptide binding]; other site 366394006045 catalytic residue [active] 366394006046 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 366394006047 Transcriptional regulator [Transcription]; Region: IclR; COG1414 366394006048 Bacterial transcriptional regulator; Region: IclR; pfam01614 366394006049 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 366394006050 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 366394006051 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 366394006052 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 366394006053 phosphate binding site [ion binding]; other site 366394006054 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 366394006055 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 366394006056 active site 366394006057 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 366394006058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394006059 non-specific DNA binding site [nucleotide binding]; other site 366394006060 salt bridge; other site 366394006061 sequence-specific DNA binding site [nucleotide binding]; other site 366394006062 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 366394006063 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 366394006064 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 366394006065 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 366394006066 GTP binding site; other site 366394006067 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK14690 366394006068 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 366394006069 dimer interface [polypeptide binding]; other site 366394006070 putative functional site; other site 366394006071 putative MPT binding site; other site 366394006072 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 366394006073 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 366394006074 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 366394006075 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 366394006076 [4Fe-4S] binding site [ion binding]; other site 366394006077 molybdopterin cofactor binding site; other site 366394006078 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 366394006079 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 366394006080 molybdopterin cofactor binding site; other site 366394006081 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 366394006082 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 366394006083 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 366394006084 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 366394006085 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 366394006086 4Fe-4S binding domain; Region: Fer4; pfam00037 366394006087 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 366394006088 FOG: WD40 repeat [General function prediction only]; Region: COG2319 366394006089 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 366394006090 structural tetrad; other site 366394006091 Cytochrome c; Region: Cytochrom_C; cl11414 366394006092 Helix-turn-helix domain; Region: HTH_17; pfam12728 366394006093 PBP superfamily domain; Region: PBP_like; pfam12727 366394006094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 366394006095 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 366394006096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394006097 Walker A/P-loop; other site 366394006098 ATP binding site [chemical binding]; other site 366394006099 Q-loop/lid; other site 366394006100 ABC transporter signature motif; other site 366394006101 Walker B; other site 366394006102 D-loop; other site 366394006103 H-loop/switch region; other site 366394006104 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 366394006105 PBP superfamily domain; Region: PBP_like_2; pfam12849 366394006106 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 366394006107 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 366394006108 MPT binding site; other site 366394006109 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 366394006110 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 366394006111 dimer interface [polypeptide binding]; other site 366394006112 putative functional site; other site 366394006113 putative MPT binding site; other site 366394006114 PBP superfamily domain; Region: PBP_like; pfam12727 366394006115 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394006116 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 366394006117 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 366394006118 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 366394006119 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 366394006120 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 366394006121 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 366394006122 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 366394006123 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 366394006124 putative active site [active] 366394006125 putative NTP binding site [chemical binding]; other site 366394006126 putative nucleic acid binding site [nucleotide binding]; other site 366394006127 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 366394006128 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 366394006129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394006130 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 366394006131 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 366394006132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394006133 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 366394006134 Transposase; Region: HTH_Tnp_1; pfam01527 366394006135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 366394006136 Isochorismatase family; Region: Isochorismatase; pfam00857 366394006137 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 366394006138 catalytic triad [active] 366394006139 conserved cis-peptide bond; other site 366394006140 Epoxide hydrolase N terminus; Region: EHN; pfam06441 366394006141 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 366394006142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394006143 Response regulator receiver domain; Region: Response_reg; pfam00072 366394006144 active site 366394006145 phosphorylation site [posttranslational modification] 366394006146 intermolecular recognition site; other site 366394006147 dimerization interface [polypeptide binding]; other site 366394006148 PAS fold; Region: PAS_4; pfam08448 366394006149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394006150 PAS domain; Region: PAS_9; pfam13426 366394006151 putative active site [active] 366394006152 heme pocket [chemical binding]; other site 366394006153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394006154 PAS fold; Region: PAS_3; pfam08447 366394006155 putative active site [active] 366394006156 heme pocket [chemical binding]; other site 366394006157 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 366394006158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394006159 putative active site [active] 366394006160 heme pocket [chemical binding]; other site 366394006161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394006162 dimer interface [polypeptide binding]; other site 366394006163 phosphorylation site [posttranslational modification] 366394006164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394006165 ATP binding site [chemical binding]; other site 366394006166 Mg2+ binding site [ion binding]; other site 366394006167 G-X-G motif; other site 366394006168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394006169 Response regulator receiver domain; Region: Response_reg; pfam00072 366394006170 active site 366394006171 phosphorylation site [posttranslational modification] 366394006172 intermolecular recognition site; other site 366394006173 dimerization interface [polypeptide binding]; other site 366394006174 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394006175 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 366394006176 putative active site [active] 366394006177 heme pocket [chemical binding]; other site 366394006178 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394006179 heme pocket [chemical binding]; other site 366394006180 putative active site [active] 366394006181 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394006182 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394006183 dimer interface [polypeptide binding]; other site 366394006184 phosphorylation site [posttranslational modification] 366394006185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394006186 ATP binding site [chemical binding]; other site 366394006187 Mg2+ binding site [ion binding]; other site 366394006188 G-X-G motif; other site 366394006189 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 366394006190 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394006191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394006192 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 366394006193 putative effector binding pocket; other site 366394006194 putative dimerization interface [polypeptide binding]; other site 366394006195 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 366394006196 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394006197 Epoxide hydrolase N terminus; Region: EHN; pfam06441 366394006198 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 366394006199 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 366394006200 classical (c) SDRs; Region: SDR_c; cd05233 366394006201 NAD(P) binding site [chemical binding]; other site 366394006202 active site 366394006203 D-cysteine desulfhydrase; Validated; Region: PRK03910 366394006204 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 366394006205 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 366394006206 catalytic residue [active] 366394006207 Predicted flavoprotein [General function prediction only]; Region: COG0431 366394006208 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 366394006209 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 366394006210 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 366394006211 substrate binding site [chemical binding]; other site 366394006212 oxyanion hole (OAH) forming residues; other site 366394006213 trimer interface [polypeptide binding]; other site 366394006214 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 366394006215 homotrimer interaction site [polypeptide binding]; other site 366394006216 putative active site [active] 366394006217 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394006218 classical (c) SDRs; Region: SDR_c; cd05233 366394006219 NAD(P) binding site [chemical binding]; other site 366394006220 active site 366394006221 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 366394006222 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 366394006223 FMN binding site [chemical binding]; other site 366394006224 substrate binding site [chemical binding]; other site 366394006225 putative catalytic residue [active] 366394006226 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 366394006227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394006228 putative substrate translocation pore; other site 366394006229 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 366394006230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394006231 active site 366394006232 phosphorylation site [posttranslational modification] 366394006233 intermolecular recognition site; other site 366394006234 dimerization interface [polypeptide binding]; other site 366394006235 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394006236 DNA binding residues [nucleotide binding] 366394006237 dimerization interface [polypeptide binding]; other site 366394006238 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 366394006239 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 366394006240 potential catalytic triad [active] 366394006241 conserved cys residue [active] 366394006242 SnoaL-like domain; Region: SnoaL_3; pfam13474 366394006243 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 366394006244 Ca2+ binding site [ion binding]; other site 366394006245 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 366394006246 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 366394006247 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 366394006248 dimer interface [polypeptide binding]; other site 366394006249 NADP binding site [chemical binding]; other site 366394006250 catalytic residues [active] 366394006251 PAS fold; Region: PAS; pfam00989 366394006252 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394006253 putative active site [active] 366394006254 heme pocket [chemical binding]; other site 366394006255 PAS domain; Region: PAS_9; pfam13426 366394006256 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 366394006257 PAS fold; Region: PAS_3; pfam08447 366394006258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394006259 ATP binding site [chemical binding]; other site 366394006260 Mg2+ binding site [ion binding]; other site 366394006261 G-X-G motif; other site 366394006262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394006263 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394006264 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394006265 DNA binding site [nucleotide binding] 366394006266 domain linker motif; other site 366394006267 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 366394006268 dimerization interface [polypeptide binding]; other site 366394006269 ligand binding site [chemical binding]; other site 366394006270 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394006271 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 366394006272 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 366394006273 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 366394006274 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394006275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394006276 dimer interface [polypeptide binding]; other site 366394006277 conserved gate region; other site 366394006278 putative PBP binding loops; other site 366394006279 ABC-ATPase subunit interface; other site 366394006280 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 366394006281 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 366394006282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394006283 dimer interface [polypeptide binding]; other site 366394006284 conserved gate region; other site 366394006285 putative PBP binding loops; other site 366394006286 ABC-ATPase subunit interface; other site 366394006287 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 366394006288 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394006289 Walker A/P-loop; other site 366394006290 ATP binding site [chemical binding]; other site 366394006291 Q-loop/lid; other site 366394006292 ABC transporter signature motif; other site 366394006293 Walker B; other site 366394006294 D-loop; other site 366394006295 H-loop/switch region; other site 366394006296 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394006297 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394006298 Walker A/P-loop; other site 366394006299 ATP binding site [chemical binding]; other site 366394006300 Q-loop/lid; other site 366394006301 ABC transporter signature motif; other site 366394006302 Walker B; other site 366394006303 D-loop; other site 366394006304 H-loop/switch region; other site 366394006305 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394006306 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 366394006307 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 366394006308 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 366394006309 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 366394006310 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 366394006311 MOFRL family; Region: MOFRL; pfam05161 366394006312 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 366394006313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394006314 NAD(P) binding site [chemical binding]; other site 366394006315 active site 366394006316 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 366394006317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394006318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394006319 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 366394006320 putative effector binding pocket; other site 366394006321 putative dimerization interface [polypeptide binding]; other site 366394006322 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 366394006323 Acyl transferase domain; Region: Acyl_transf_1; cl08282 366394006324 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 366394006325 methionine sulfoxide reductase A; Provisional; Region: PRK14054 366394006326 methionine sulfoxide reductase B; Provisional; Region: PRK00222 366394006327 SelR domain; Region: SelR; pfam01641 366394006328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394006329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394006330 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 366394006331 dimerization interface [polypeptide binding]; other site 366394006332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394006333 ATP binding site [chemical binding]; other site 366394006334 Mg2+ binding site [ion binding]; other site 366394006335 G-X-G motif; other site 366394006336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394006337 active site 366394006338 phosphorylation site [posttranslational modification] 366394006339 intermolecular recognition site; other site 366394006340 dimerization interface [polypeptide binding]; other site 366394006341 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 366394006342 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 366394006343 Walker A motif; other site 366394006344 ATP binding site [chemical binding]; other site 366394006345 Walker B motif; other site 366394006346 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 366394006347 KaiC; Region: KaiC; pfam06745 366394006348 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 366394006349 Walker A motif; other site 366394006350 Walker A motif; other site 366394006351 ATP binding site [chemical binding]; other site 366394006352 Walker B motif; other site 366394006353 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 366394006354 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394006355 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394006356 Walker A/P-loop; other site 366394006357 ATP binding site [chemical binding]; other site 366394006358 Q-loop/lid; other site 366394006359 ABC transporter signature motif; other site 366394006360 Walker B; other site 366394006361 D-loop; other site 366394006362 H-loop/switch region; other site 366394006363 TOBE domain; Region: TOBE_2; pfam08402 366394006364 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394006365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394006366 dimer interface [polypeptide binding]; other site 366394006367 conserved gate region; other site 366394006368 putative PBP binding loops; other site 366394006369 ABC-ATPase subunit interface; other site 366394006370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394006371 dimer interface [polypeptide binding]; other site 366394006372 conserved gate region; other site 366394006373 putative PBP binding loops; other site 366394006374 ABC-ATPase subunit interface; other site 366394006375 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394006376 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394006377 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 366394006378 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 366394006379 Predicted transcriptional regulator [Transcription]; Region: COG4189 366394006380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394006381 dimerization interface [polypeptide binding]; other site 366394006382 putative DNA binding site [nucleotide binding]; other site 366394006383 putative Zn2+ binding site [ion binding]; other site 366394006384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394006385 active site 366394006386 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394006387 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 366394006388 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394006389 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394006390 putative DNA binding site [nucleotide binding]; other site 366394006391 putative Zn2+ binding site [ion binding]; other site 366394006392 AsnC family; Region: AsnC_trans_reg; pfam01037 366394006393 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 366394006394 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394006395 Walker A/P-loop; other site 366394006396 ATP binding site [chemical binding]; other site 366394006397 Q-loop/lid; other site 366394006398 ABC transporter signature motif; other site 366394006399 Walker B; other site 366394006400 D-loop; other site 366394006401 H-loop/switch region; other site 366394006402 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394006403 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394006404 Walker A/P-loop; other site 366394006405 ATP binding site [chemical binding]; other site 366394006406 Q-loop/lid; other site 366394006407 ABC transporter signature motif; other site 366394006408 Walker B; other site 366394006409 D-loop; other site 366394006410 H-loop/switch region; other site 366394006411 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394006412 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 366394006413 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 366394006414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394006415 dimer interface [polypeptide binding]; other site 366394006416 conserved gate region; other site 366394006417 ABC-ATPase subunit interface; other site 366394006418 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394006419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394006420 dimer interface [polypeptide binding]; other site 366394006421 conserved gate region; other site 366394006422 putative PBP binding loops; other site 366394006423 ABC-ATPase subunit interface; other site 366394006424 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394006425 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 366394006426 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 366394006427 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 366394006428 hypothetical protein; Provisional; Region: PRK05965 366394006429 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 366394006430 inhibitor-cofactor binding pocket; inhibition site 366394006431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394006432 catalytic residue [active] 366394006433 putative acetyltransferase; Provisional; Region: PRK03624 366394006434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394006435 Coenzyme A binding pocket [chemical binding]; other site 366394006436 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 366394006437 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 366394006438 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 366394006439 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394006440 succinic semialdehyde dehydrogenase; Region: PLN02278 366394006441 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 366394006442 tetramerization interface [polypeptide binding]; other site 366394006443 NAD(P) binding site [chemical binding]; other site 366394006444 catalytic residues [active] 366394006445 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 366394006446 tartrate dehydrogenase; Region: TTC; TIGR02089 366394006447 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 366394006448 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 366394006449 NAD(P) binding site [chemical binding]; other site 366394006450 catalytic residues [active] 366394006451 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 366394006452 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 366394006453 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 366394006454 putative ligand binding site [chemical binding]; other site 366394006455 NAD binding site [chemical binding]; other site 366394006456 dimerization interface [polypeptide binding]; other site 366394006457 catalytic site [active] 366394006458 acetylornithine deacetylase; Provisional; Region: PRK07522 366394006459 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 366394006460 metal binding site [ion binding]; metal-binding site 366394006461 putative dimer interface [polypeptide binding]; other site 366394006462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394006463 Coenzyme A binding pocket [chemical binding]; other site 366394006464 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 366394006465 Predicted membrane protein [Function unknown]; Region: COG1238 366394006466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394006467 putative substrate translocation pore; other site 366394006468 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 366394006469 putative homodimer interface [polypeptide binding]; other site 366394006470 putative homotetramer interface [polypeptide binding]; other site 366394006471 putative metal binding site [ion binding]; other site 366394006472 putative homodimer-homodimer interface [polypeptide binding]; other site 366394006473 putative allosteric switch controlling residues; other site 366394006474 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 366394006475 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394006476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394006477 DNA-binding site [nucleotide binding]; DNA binding site 366394006478 FCD domain; Region: FCD; pfam07729 366394006479 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394006480 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 366394006481 substrate binding site [chemical binding]; other site 366394006482 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394006483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394006484 dimer interface [polypeptide binding]; other site 366394006485 conserved gate region; other site 366394006486 putative PBP binding loops; other site 366394006487 ABC-ATPase subunit interface; other site 366394006488 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 366394006489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394006490 dimer interface [polypeptide binding]; other site 366394006491 conserved gate region; other site 366394006492 putative PBP binding loops; other site 366394006493 ABC-ATPase subunit interface; other site 366394006494 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 366394006495 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394006496 Walker A/P-loop; other site 366394006497 ATP binding site [chemical binding]; other site 366394006498 Q-loop/lid; other site 366394006499 ABC transporter signature motif; other site 366394006500 Walker B; other site 366394006501 D-loop; other site 366394006502 H-loop/switch region; other site 366394006503 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394006504 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 366394006505 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394006506 Walker A/P-loop; other site 366394006507 ATP binding site [chemical binding]; other site 366394006508 Q-loop/lid; other site 366394006509 ABC transporter signature motif; other site 366394006510 Walker B; other site 366394006511 D-loop; other site 366394006512 H-loop/switch region; other site 366394006513 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394006514 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 366394006515 Integrase core domain; Region: rve; pfam00665 366394006516 transposase; Provisional; Region: PRK06526 366394006517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394006518 Walker A motif; other site 366394006519 ATP binding site [chemical binding]; other site 366394006520 Walker B motif; other site 366394006521 LssY C-terminus; Region: LssY_C; pfam14067 366394006522 Response regulator receiver domain; Region: Response_reg; pfam00072 366394006523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394006524 active site 366394006525 phosphorylation site [posttranslational modification] 366394006526 intermolecular recognition site; other site 366394006527 dimerization interface [polypeptide binding]; other site 366394006528 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 366394006529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394006530 active site 366394006531 phosphorylation site [posttranslational modification] 366394006532 intermolecular recognition site; other site 366394006533 dimerization interface [polypeptide binding]; other site 366394006534 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394006535 DNA binding residues [nucleotide binding] 366394006536 dimerization interface [polypeptide binding]; other site 366394006537 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 366394006538 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394006539 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394006540 dimer interface [polypeptide binding]; other site 366394006541 phosphorylation site [posttranslational modification] 366394006542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394006543 ATP binding site [chemical binding]; other site 366394006544 Mg2+ binding site [ion binding]; other site 366394006545 G-X-G motif; other site 366394006546 Uncharacterized conserved protein [Function unknown]; Region: COG5361 366394006547 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 366394006548 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 366394006549 Uncharacterized conserved protein [Function unknown]; Region: COG5361 366394006550 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 366394006551 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 366394006552 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 366394006553 active site 366394006554 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 366394006555 Mechanosensitive ion channel; Region: MS_channel; pfam00924 366394006556 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 366394006557 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 366394006558 active site 366394006559 non-prolyl cis peptide bond; other site 366394006560 Putative NADH-flavin reductase [General function prediction only]; Region: COG2910 366394006561 NADH(P)-binding; Region: NAD_binding_10; pfam13460 366394006562 NAD(P) binding site [chemical binding]; other site 366394006563 active site 366394006564 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 366394006565 hypothetical protein; Provisional; Region: PRK07236 366394006566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394006567 NmrA-like family; Region: NmrA; pfam05368 366394006568 NAD(P) binding site [chemical binding]; other site 366394006569 active site 366394006570 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 366394006571 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 366394006572 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 366394006573 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 366394006574 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 366394006575 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394006576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394006577 dimer interface [polypeptide binding]; other site 366394006578 conserved gate region; other site 366394006579 putative PBP binding loops; other site 366394006580 ABC-ATPase subunit interface; other site 366394006581 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 366394006582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394006583 dimer interface [polypeptide binding]; other site 366394006584 conserved gate region; other site 366394006585 putative PBP binding loops; other site 366394006586 ABC-ATPase subunit interface; other site 366394006587 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 366394006588 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394006589 Walker A/P-loop; other site 366394006590 ATP binding site [chemical binding]; other site 366394006591 Q-loop/lid; other site 366394006592 ABC transporter signature motif; other site 366394006593 Walker B; other site 366394006594 D-loop; other site 366394006595 H-loop/switch region; other site 366394006596 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394006597 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 366394006598 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394006599 Walker A/P-loop; other site 366394006600 ATP binding site [chemical binding]; other site 366394006601 Q-loop/lid; other site 366394006602 ABC transporter signature motif; other site 366394006603 Walker B; other site 366394006604 D-loop; other site 366394006605 H-loop/switch region; other site 366394006606 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 366394006607 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394006608 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394006609 active site 366394006610 catalytic tetrad [active] 366394006611 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394006612 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 366394006613 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 366394006614 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 366394006615 Flavin binding site [chemical binding]; other site 366394006616 Ion channel; Region: Ion_trans_2; pfam07885 366394006617 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 366394006618 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 366394006619 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 366394006620 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 366394006621 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394006622 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 366394006623 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 366394006624 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 366394006625 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 366394006626 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 366394006627 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394006628 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394006629 metal binding site [ion binding]; metal-binding site 366394006630 active site 366394006631 I-site; other site 366394006632 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 366394006633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394006634 non-specific DNA binding site [nucleotide binding]; other site 366394006635 salt bridge; other site 366394006636 sequence-specific DNA binding site [nucleotide binding]; other site 366394006637 HipA N-terminal domain; Region: Couple_hipA; cl11853 366394006638 HipA-like N-terminal domain; Region: HipA_N; pfam07805 366394006639 HipA-like C-terminal domain; Region: HipA_C; pfam07804 366394006640 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 366394006641 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394006642 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 366394006643 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394006644 putative homodimer interface [polypeptide binding]; other site 366394006645 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 366394006646 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 366394006647 UDP-galactopyranose mutase; Region: GLF; pfam03275 366394006648 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394006649 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 366394006650 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394006651 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394006652 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 366394006653 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 366394006654 putative NAD(P) binding site [chemical binding]; other site 366394006655 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 366394006656 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394006657 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 366394006658 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 366394006659 SnoaL-like domain; Region: SnoaL_4; pfam13577 366394006660 SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487 366394006661 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394006662 cyclase homology domain; Region: CHD; cd07302 366394006663 nucleotidyl binding site; other site 366394006664 metal binding site [ion binding]; metal-binding site 366394006665 dimer interface [polypeptide binding]; other site 366394006666 Predicted ATPase [General function prediction only]; Region: COG3899 366394006667 AAA ATPase domain; Region: AAA_16; pfam13191 366394006668 Predicted ATPase [General function prediction only]; Region: COG3903 366394006669 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 366394006670 Zn binding site [ion binding]; other site 366394006671 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 366394006672 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 366394006673 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 366394006674 ligand binding site [chemical binding]; other site 366394006675 flexible hinge region; other site 366394006676 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 366394006677 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394006678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394006679 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 366394006680 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 366394006681 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 366394006682 shikimate binding site; other site 366394006683 NAD(P) binding site [chemical binding]; other site 366394006684 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394006685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394006686 DNA-binding site [nucleotide binding]; DNA binding site 366394006687 FCD domain; Region: FCD; pfam07729 366394006688 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 366394006689 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 366394006690 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 366394006691 DctM-like transporters; Region: DctM; pfam06808 366394006692 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 366394006693 Dehydroquinase class II; Region: DHquinase_II; pfam01220 366394006694 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 366394006695 trimer interface [polypeptide binding]; other site 366394006696 active site 366394006697 dimer interface [polypeptide binding]; other site 366394006698 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 366394006699 LysE type translocator; Region: LysE; cl00565 366394006700 Cupin domain; Region: Cupin_2; pfam07883 366394006701 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 366394006702 MarR family; Region: MarR_2; cl17246 366394006703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394006704 NmrA-like family; Region: NmrA; pfam05368 366394006705 NAD(P) binding site [chemical binding]; other site 366394006706 active site 366394006707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 366394006708 HTH-like domain; Region: HTH_21; pfam13276 366394006709 Integrase core domain; Region: rve; pfam00665 366394006710 Integrase core domain; Region: rve_3; pfam13683 366394006711 Transposase; Region: HTH_Tnp_1; pfam01527 366394006712 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 366394006713 active site 366394006714 Epoxide hydrolase N terminus; Region: EHN; pfam06441 366394006715 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 366394006716 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 366394006717 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 366394006718 NAD binding site [chemical binding]; other site 366394006719 catalytic residues [active] 366394006720 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394006721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394006722 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 366394006723 putative effector binding pocket; other site 366394006724 putative dimerization interface [polypeptide binding]; other site 366394006725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394006726 S-adenosylmethionine binding site [chemical binding]; other site 366394006727 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 366394006728 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394006729 DNA binding site [nucleotide binding] 366394006730 Predicted integral membrane protein [Function unknown]; Region: COG5616 366394006731 TPR repeat; Region: TPR_11; pfam13414 366394006732 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394006733 binding surface 366394006734 TPR motif; other site 366394006735 TPR repeat; Region: TPR_11; pfam13414 366394006736 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 366394006737 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 366394006738 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 366394006739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394006740 GAF domain; Region: GAF; pfam01590 366394006741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 366394006742 HWE histidine kinase; Region: HWE_HK; pfam07536 366394006743 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394006744 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394006745 Walker A/P-loop; other site 366394006746 ATP binding site [chemical binding]; other site 366394006747 Q-loop/lid; other site 366394006748 ABC transporter signature motif; other site 366394006749 Walker B; other site 366394006750 D-loop; other site 366394006751 H-loop/switch region; other site 366394006752 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394006753 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394006754 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 366394006755 ligand binding site [chemical binding]; other site 366394006756 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394006757 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394006758 TM-ABC transporter signature motif; other site 366394006759 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 366394006760 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 366394006761 substrate binding site [chemical binding]; other site 366394006762 oxyanion hole (OAH) forming residues; other site 366394006763 trimer interface [polypeptide binding]; other site 366394006764 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 366394006765 CoA-transferase family III; Region: CoA_transf_3; pfam02515 366394006766 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 366394006767 classical (c) SDRs; Region: SDR_c; cd05233 366394006768 NAD(P) binding site [chemical binding]; other site 366394006769 active site 366394006770 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 366394006771 active site 366394006772 catalytic residues [active] 366394006773 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 366394006774 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 366394006775 AP (apurinic/apyrimidinic) site pocket; other site 366394006776 DNA interaction; other site 366394006777 Metal-binding active site; metal-binding site 366394006778 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394006779 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394006780 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394006781 DNA binding site [nucleotide binding] 366394006782 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 366394006783 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 366394006784 putative ligand binding site [chemical binding]; other site 366394006785 response regulator; Provisional; Region: PRK13435 366394006786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 366394006787 HWE histidine kinase; Region: HWE_HK; pfam07536 366394006788 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 366394006789 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 366394006790 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 366394006791 Walker A motif; other site 366394006792 Walker A motif; other site 366394006793 ATP binding site [chemical binding]; other site 366394006794 Walker B motif; other site 366394006795 KaiC; Region: KaiC; pfam06745 366394006796 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 366394006797 Walker A motif; other site 366394006798 ATP binding site [chemical binding]; other site 366394006799 Walker B motif; other site 366394006800 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 366394006801 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 366394006802 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394006803 cyclase homology domain; Region: CHD; cd07302 366394006804 nucleotidyl binding site; other site 366394006805 metal binding site [ion binding]; metal-binding site 366394006806 dimer interface [polypeptide binding]; other site 366394006807 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 366394006808 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 366394006809 ligand binding site [chemical binding]; other site 366394006810 Predicted periplasmic protein [Function unknown]; Region: COG3900 366394006811 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 366394006812 amphipathic channel; other site 366394006813 Asn-Pro-Ala signature motifs; other site 366394006814 Transposase; Region: HTH_Tnp_1; cl17663 366394006815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 366394006816 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 366394006817 Sulfatase; Region: Sulfatase; pfam00884 366394006818 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 366394006819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394006820 motif II; other site 366394006821 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 366394006822 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 366394006823 TPR repeat; Region: TPR_11; pfam13414 366394006824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394006825 TPR motif; other site 366394006826 binding surface 366394006827 Tetratricopeptide repeat; Region: TPR_16; pfam13432 366394006828 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 366394006829 Mechanosensitive ion channel; Region: MS_channel; pfam00924 366394006830 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 366394006831 active site 366394006832 catalytic residues [active] 366394006833 CheB methylesterase; Region: CheB_methylest; pfam01339 366394006834 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 366394006835 CheB methylesterase; Region: CheB_methylest; pfam01339 366394006836 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 366394006837 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 366394006838 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 366394006839 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 366394006840 PAS domain; Region: PAS_10; pfam13596 366394006841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394006842 putative active site [active] 366394006843 heme pocket [chemical binding]; other site 366394006844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394006845 PAS domain; Region: PAS_9; pfam13426 366394006846 putative active site [active] 366394006847 heme pocket [chemical binding]; other site 366394006848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 366394006849 HWE histidine kinase; Region: HWE_HK; pfam07536 366394006850 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 366394006851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 366394006852 active site 366394006853 phosphorylation site [posttranslational modification] 366394006854 dimerization interface [polypeptide binding]; other site 366394006855 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 366394006856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394006857 Coenzyme A binding pocket [chemical binding]; other site 366394006858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394006859 S-adenosylmethionine binding site [chemical binding]; other site 366394006860 Autoinducer binding domain; Region: Autoind_bind; pfam03472 366394006861 transcriptional regulator TraR; Provisional; Region: PRK13870 366394006862 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394006863 DNA binding residues [nucleotide binding] 366394006864 dimerization interface [polypeptide binding]; other site 366394006865 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 366394006866 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 366394006867 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394006868 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394006869 DNA-binding site [nucleotide binding]; DNA binding site 366394006870 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 366394006871 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 366394006872 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394006873 Walker A/P-loop; other site 366394006874 ATP binding site [chemical binding]; other site 366394006875 Q-loop/lid; other site 366394006876 ABC transporter signature motif; other site 366394006877 Walker B; other site 366394006878 D-loop; other site 366394006879 H-loop/switch region; other site 366394006880 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 366394006881 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 366394006882 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394006883 Walker A/P-loop; other site 366394006884 ATP binding site [chemical binding]; other site 366394006885 Q-loop/lid; other site 366394006886 ABC transporter signature motif; other site 366394006887 Walker B; other site 366394006888 D-loop; other site 366394006889 H-loop/switch region; other site 366394006890 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 366394006891 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 366394006892 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 366394006893 active site 366394006894 cytosine deaminase; Provisional; Region: PRK05985 366394006895 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 366394006896 active site 366394006897 dipeptide transporter; Provisional; Region: PRK10913 366394006898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394006899 dimer interface [polypeptide binding]; other site 366394006900 conserved gate region; other site 366394006901 putative PBP binding loops; other site 366394006902 ABC-ATPase subunit interface; other site 366394006903 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394006904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394006905 dimer interface [polypeptide binding]; other site 366394006906 conserved gate region; other site 366394006907 putative PBP binding loops; other site 366394006908 ABC-ATPase subunit interface; other site 366394006909 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394006910 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 366394006911 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394006912 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 366394006913 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 366394006914 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 366394006915 active site 366394006916 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 366394006917 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 366394006918 NADP binding site [chemical binding]; other site 366394006919 homodimer interface [polypeptide binding]; other site 366394006920 active site 366394006921 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 366394006922 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 366394006923 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394006924 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394006925 non-specific DNA binding site [nucleotide binding]; other site 366394006926 salt bridge; other site 366394006927 sequence-specific DNA binding site [nucleotide binding]; other site 366394006928 HipA N-terminal domain; Region: Couple_hipA; pfam13657 366394006929 HipA-like N-terminal domain; Region: HipA_N; pfam07805 366394006930 HipA-like C-terminal domain; Region: HipA_C; pfam07804 366394006931 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 366394006932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394006933 NAD(P) binding site [chemical binding]; other site 366394006934 active site 366394006935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394006936 LysR substrate binding domain; Region: LysR_substrate; pfam03466 366394006937 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 366394006938 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 366394006939 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 366394006940 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 366394006941 Transcriptional regulators [Transcription]; Region: MarR; COG1846 366394006942 MarR family; Region: MarR; pfam01047 366394006943 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 366394006944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394006945 NADH(P)-binding; Region: NAD_binding_10; pfam13460 366394006946 NAD(P) binding site [chemical binding]; other site 366394006947 active site 366394006948 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 366394006949 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 366394006950 Mechanosensitive ion channel; Region: MS_channel; pfam00924 366394006951 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 366394006952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394006953 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 366394006954 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 366394006955 Helix-turn-helix domain; Region: HTH_18; pfam12833 366394006956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394006957 short chain dehydrogenase; Provisional; Region: PRK06500 366394006958 classical (c) SDRs; Region: SDR_c; cd05233 366394006959 NAD(P) binding site [chemical binding]; other site 366394006960 active site 366394006961 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394006962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394006963 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 366394006964 putative effector binding pocket; other site 366394006965 dimerization interface [polypeptide binding]; other site 366394006966 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 366394006967 active site 366394006968 catalytic residues [active] 366394006969 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 366394006970 classical (c) SDRs; Region: SDR_c; cd05233 366394006971 NAD(P) binding site [chemical binding]; other site 366394006972 active site 366394006973 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 366394006974 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394006975 Walker A/P-loop; other site 366394006976 ATP binding site [chemical binding]; other site 366394006977 Q-loop/lid; other site 366394006978 ABC transporter signature motif; other site 366394006979 Walker B; other site 366394006980 D-loop; other site 366394006981 H-loop/switch region; other site 366394006982 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394006983 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394006984 TM-ABC transporter signature motif; other site 366394006985 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394006986 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 366394006987 putative ligand binding site [chemical binding]; other site 366394006988 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394006989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394006990 DNA-binding site [nucleotide binding]; DNA binding site 366394006991 FCD domain; Region: FCD; pfam07729 366394006992 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 366394006993 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 366394006994 active site pocket [active] 366394006995 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394006996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394006997 DNA-binding site [nucleotide binding]; DNA binding site 366394006998 FCD domain; Region: FCD; pfam07729 366394006999 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394007000 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394007001 DNA-binding site [nucleotide binding]; DNA binding site 366394007002 FCD domain; Region: FCD; pfam07729 366394007003 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 366394007004 aldose dehydrogenase; Validated; Region: PRK06398 366394007005 classical (c) SDRs; Region: SDR_c; cd05233 366394007006 NAD(P) binding site [chemical binding]; other site 366394007007 active site 366394007008 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 366394007009 dimerization interface [polypeptide binding]; other site 366394007010 putative active cleft [active] 366394007011 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 366394007012 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 366394007013 metal binding site [ion binding]; metal-binding site 366394007014 substrate binding pocket [chemical binding]; other site 366394007015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394007016 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 366394007017 putative hydrophobic ligand binding site [chemical binding]; other site 366394007018 Uncharacterized conserved protein [Function unknown]; Region: COG5552 366394007019 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 366394007020 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 366394007021 putative NAD(P) binding site [chemical binding]; other site 366394007022 transcriptional regulator; Provisional; Region: PRK10632 366394007023 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394007024 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 366394007025 putative effector binding pocket; other site 366394007026 putative dimerization interface [polypeptide binding]; other site 366394007027 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 366394007028 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 366394007029 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 366394007030 active site 366394007031 Cupin domain; Region: Cupin_2; pfam07883 366394007032 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 366394007033 Uncharacterized conserved protein [Function unknown]; Region: COG5441 366394007034 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 366394007035 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394007036 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394007037 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 366394007038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394007039 conserved gate region; other site 366394007040 dimer interface [polypeptide binding]; other site 366394007041 putative PBP binding loops; other site 366394007042 ABC-ATPase subunit interface; other site 366394007043 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394007044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394007045 dimer interface [polypeptide binding]; other site 366394007046 conserved gate region; other site 366394007047 putative PBP binding loops; other site 366394007048 ABC-ATPase subunit interface; other site 366394007049 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394007050 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394007051 Walker A/P-loop; other site 366394007052 ATP binding site [chemical binding]; other site 366394007053 Q-loop/lid; other site 366394007054 ABC transporter signature motif; other site 366394007055 Walker B; other site 366394007056 D-loop; other site 366394007057 H-loop/switch region; other site 366394007058 TOBE domain; Region: TOBE_2; pfam08402 366394007059 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394007060 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394007061 Walker A/P-loop; other site 366394007062 ATP binding site [chemical binding]; other site 366394007063 Q-loop/lid; other site 366394007064 ABC transporter signature motif; other site 366394007065 Walker B; other site 366394007066 D-loop; other site 366394007067 H-loop/switch region; other site 366394007068 TOBE domain; Region: TOBE_2; pfam08402 366394007069 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 366394007070 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 366394007071 ligand binding site [chemical binding]; other site 366394007072 NAD binding site [chemical binding]; other site 366394007073 dimerization interface [polypeptide binding]; other site 366394007074 catalytic site [active] 366394007075 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394007076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394007077 DNA-binding site [nucleotide binding]; DNA binding site 366394007078 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 366394007079 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 366394007080 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 366394007081 active site pocket [active] 366394007082 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 366394007083 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 366394007084 DNA interaction; other site 366394007085 Metal-binding active site; metal-binding site 366394007086 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 366394007087 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 366394007088 Metal-binding active site; metal-binding site 366394007089 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394007090 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 366394007091 putative C-terminal domain interface [polypeptide binding]; other site 366394007092 putative GSH binding site (G-site) [chemical binding]; other site 366394007093 putative dimer interface [polypeptide binding]; other site 366394007094 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 366394007095 putative N-terminal domain interface [polypeptide binding]; other site 366394007096 putative dimer interface [polypeptide binding]; other site 366394007097 putative substrate binding pocket (H-site) [chemical binding]; other site 366394007098 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 366394007099 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 366394007100 [2Fe-2S] cluster binding site [ion binding]; other site 366394007101 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 366394007102 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 366394007103 FMN-binding pocket [chemical binding]; other site 366394007104 flavin binding motif; other site 366394007105 phosphate binding motif [ion binding]; other site 366394007106 beta-alpha-beta structure motif; other site 366394007107 NAD binding pocket [chemical binding]; other site 366394007108 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394007109 catalytic loop [active] 366394007110 iron binding site [ion binding]; other site 366394007111 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 366394007112 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 366394007113 hydrophobic ligand binding site; other site 366394007114 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 366394007115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394007116 DNA-binding site [nucleotide binding]; DNA binding site 366394007117 FCD domain; Region: FCD; pfam07729 366394007118 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 366394007119 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 366394007120 putative ligand binding site [chemical binding]; other site 366394007121 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 366394007122 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394007123 Walker A/P-loop; other site 366394007124 ATP binding site [chemical binding]; other site 366394007125 Q-loop/lid; other site 366394007126 ABC transporter signature motif; other site 366394007127 Walker B; other site 366394007128 D-loop; other site 366394007129 H-loop/switch region; other site 366394007130 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394007131 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394007132 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 366394007133 TM-ABC transporter signature motif; other site 366394007134 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394007135 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 366394007136 TM-ABC transporter signature motif; other site 366394007137 aminoglycoside resistance protein; Provisional; Region: PRK13746 366394007138 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 366394007139 active site 366394007140 NTP binding site [chemical binding]; other site 366394007141 metal binding triad [ion binding]; metal-binding site 366394007142 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 366394007143 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 366394007144 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394007145 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 366394007146 putative DNA binding site [nucleotide binding]; other site 366394007147 putative Zn2+ binding site [ion binding]; other site 366394007148 AsnC family; Region: AsnC_trans_reg; pfam01037 366394007149 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394007150 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 366394007151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394007152 dimer interface [polypeptide binding]; other site 366394007153 conserved gate region; other site 366394007154 putative PBP binding loops; other site 366394007155 ABC-ATPase subunit interface; other site 366394007156 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 366394007157 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 366394007158 Walker A/P-loop; other site 366394007159 ATP binding site [chemical binding]; other site 366394007160 Q-loop/lid; other site 366394007161 ABC transporter signature motif; other site 366394007162 Walker B; other site 366394007163 D-loop; other site 366394007164 H-loop/switch region; other site 366394007165 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 366394007166 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394007167 substrate binding pocket [chemical binding]; other site 366394007168 membrane-bound complex binding site; other site 366394007169 hinge residues; other site 366394007170 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394007171 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394007172 DNA binding site [nucleotide binding] 366394007173 domain linker motif; other site 366394007174 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 366394007175 dimerization interface [polypeptide binding]; other site 366394007176 ligand binding site [chemical binding]; other site 366394007177 Methyltransferase domain; Region: Methyltransf_31; pfam13847 366394007178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394007179 S-adenosylmethionine binding site [chemical binding]; other site 366394007180 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 366394007181 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 366394007182 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 366394007183 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394007184 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 366394007185 putative ligand binding site [chemical binding]; other site 366394007186 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 366394007187 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394007188 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394007189 TM-ABC transporter signature motif; other site 366394007190 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394007191 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394007192 Walker A/P-loop; other site 366394007193 ATP binding site [chemical binding]; other site 366394007194 Q-loop/lid; other site 366394007195 ABC transporter signature motif; other site 366394007196 Walker B; other site 366394007197 D-loop; other site 366394007198 H-loop/switch region; other site 366394007199 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394007200 Phosphotransferase enzyme family; Region: APH; pfam01636 366394007201 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 366394007202 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 366394007203 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 366394007204 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394007205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394007206 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 366394007207 putative effector binding pocket; other site 366394007208 putative dimerization interface [polypeptide binding]; other site 366394007209 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 366394007210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394007211 NAD(P) binding site [chemical binding]; other site 366394007212 active site 366394007213 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 366394007214 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394007215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 366394007216 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 366394007217 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 366394007218 [2Fe-2S] cluster binding site [ion binding]; other site 366394007219 PAS domain; Region: PAS_9; pfam13426 366394007220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 366394007221 Histidine kinase; Region: HisKA_2; pfam07568 366394007222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394007223 ATP binding site [chemical binding]; other site 366394007224 Mg2+ binding site [ion binding]; other site 366394007225 G-X-G motif; other site 366394007226 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 366394007227 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 366394007228 Sulphur transport; Region: Sulf_transp; pfam04143 366394007229 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 366394007230 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 366394007231 active site residue [active] 366394007232 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 366394007233 active site residue [active] 366394007234 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 366394007235 Part of AAA domain; Region: AAA_19; pfam13245 366394007236 Family description; Region: UvrD_C_2; pfam13538 366394007237 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394007238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394007239 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394007240 dimerization interface [polypeptide binding]; other site 366394007241 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 366394007242 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 366394007243 ligand binding site [chemical binding]; other site 366394007244 NAD binding site [chemical binding]; other site 366394007245 dimerization interface [polypeptide binding]; other site 366394007246 catalytic site [active] 366394007247 hypothetical protein; Validated; Region: PRK06201 366394007248 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 366394007249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 366394007250 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 366394007251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 366394007252 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 366394007253 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 366394007254 apolar tunnel; other site 366394007255 heme binding site [chemical binding]; other site 366394007256 dimerization interface [polypeptide binding]; other site 366394007257 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 366394007258 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 366394007259 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 366394007260 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 366394007261 active site 366394007262 homotetramer interface [polypeptide binding]; other site 366394007263 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 366394007264 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 366394007265 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 366394007266 ABC transporter; Region: ABC_tran_2; pfam12848 366394007267 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 366394007268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 366394007269 AAA domain; Region: AAA_33; pfam13671 366394007270 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 366394007271 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 366394007272 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 366394007273 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 366394007274 metal-binding site [ion binding] 366394007275 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 366394007276 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394007277 motif II; other site 366394007278 Predicted integral membrane protein [Function unknown]; Region: COG5473 366394007279 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 366394007280 Cytochrome c; Region: Cytochrom_C; pfam00034 366394007281 Cytochrome c; Region: Cytochrom_C; pfam00034 366394007282 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 366394007283 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 366394007284 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 366394007285 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 366394007286 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 366394007287 Low-spin heme binding site [chemical binding]; other site 366394007288 Putative water exit pathway; other site 366394007289 Binuclear center (active site) [active] 366394007290 Putative proton exit pathway; other site 366394007291 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 366394007292 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 366394007293 ligand binding site [chemical binding]; other site 366394007294 flexible hinge region; other site 366394007295 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 366394007296 cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847 366394007297 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 366394007298 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 366394007299 metal-binding site [ion binding] 366394007300 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 366394007301 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 366394007302 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 366394007303 FixH; Region: FixH; pfam05751 366394007304 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 366394007305 4Fe-4S binding domain; Region: Fer4_5; pfam12801 366394007306 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 366394007307 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 366394007308 Cytochrome c; Region: Cytochrom_C; pfam00034 366394007309 Cytochrome c; Region: Cytochrom_C; pfam00034 366394007310 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 366394007311 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 366394007312 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 366394007313 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 366394007314 Low-spin heme binding site [chemical binding]; other site 366394007315 Putative water exit pathway; other site 366394007316 Binuclear center (active site) [active] 366394007317 Putative proton exit pathway; other site 366394007318 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 366394007319 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 366394007320 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 366394007321 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 366394007322 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 366394007323 Homeodomain-like domain; Region: HTH_23; pfam13384 366394007324 Winged helix-turn helix; Region: HTH_29; pfam13551 366394007325 Homeodomain-like domain; Region: HTH_32; pfam13565 366394007326 DDE superfamily endonuclease; Region: DDE_3; pfam13358 366394007327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 366394007328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394007329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394007330 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 366394007331 putative substrate binding pocket [chemical binding]; other site 366394007332 putative dimerization interface [polypeptide binding]; other site 366394007333 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 366394007334 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 366394007335 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394007336 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 366394007337 putative effector binding pocket; other site 366394007338 putative dimerization interface [polypeptide binding]; other site 366394007339 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 366394007340 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 366394007341 Predicted integral membrane protein [Function unknown]; Region: COG0392 366394007342 Uncharacterized conserved protein [Function unknown]; Region: COG2898 366394007343 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 366394007344 Response regulator receiver domain; Region: Response_reg; pfam00072 366394007345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394007346 active site 366394007347 phosphorylation site [posttranslational modification] 366394007348 intermolecular recognition site; other site 366394007349 dimerization interface [polypeptide binding]; other site 366394007350 Histidine kinase; Region: HisKA_2; pfam07568 366394007351 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 366394007352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394007353 ATP binding site [chemical binding]; other site 366394007354 Mg2+ binding site [ion binding]; other site 366394007355 G-X-G motif; other site 366394007356 Response regulator receiver domain; Region: Response_reg; pfam00072 366394007357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394007358 active site 366394007359 phosphorylation site [posttranslational modification] 366394007360 intermolecular recognition site; other site 366394007361 dimerization interface [polypeptide binding]; other site 366394007362 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394007363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394007364 dimer interface [polypeptide binding]; other site 366394007365 phosphorylation site [posttranslational modification] 366394007366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394007367 ATP binding site [chemical binding]; other site 366394007368 Mg2+ binding site [ion binding]; other site 366394007369 G-X-G motif; other site 366394007370 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 366394007371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394007372 active site 366394007373 phosphorylation site [posttranslational modification] 366394007374 intermolecular recognition site; other site 366394007375 dimerization interface [polypeptide binding]; other site 366394007376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394007377 Walker A motif; other site 366394007378 ATP binding site [chemical binding]; other site 366394007379 Walker B motif; other site 366394007380 arginine finger; other site 366394007381 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 366394007382 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 366394007383 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 366394007384 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 366394007385 catalytic residues [active] 366394007386 Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion]; Region: COG5555 366394007387 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 366394007388 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 366394007389 HTH domain; Region: HTH_11; pfam08279 366394007390 Predicted transcriptional regulator [Transcription]; Region: COG2378 366394007391 WYL domain; Region: WYL; pfam13280 366394007392 Uncharacterized conserved protein [Function unknown]; Region: COG5361 366394007393 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 366394007394 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 366394007395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 366394007396 DDE superfamily endonuclease; Region: DDE_3; pfam13358 366394007397 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 366394007398 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 366394007399 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 366394007400 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 366394007401 FAD binding pocket [chemical binding]; other site 366394007402 FAD binding motif [chemical binding]; other site 366394007403 phosphate binding motif [ion binding]; other site 366394007404 beta-alpha-beta structure motif; other site 366394007405 NAD binding pocket [chemical binding]; other site 366394007406 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394007407 catalytic loop [active] 366394007408 iron binding site [ion binding]; other site 366394007409 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 366394007410 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 366394007411 [2Fe-2S] cluster binding site [ion binding]; other site 366394007412 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 366394007413 putative alpha subunit interface [polypeptide binding]; other site 366394007414 putative active site [active] 366394007415 putative substrate binding site [chemical binding]; other site 366394007416 Fe binding site [ion binding]; other site 366394007417 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 366394007418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394007419 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394007420 dimerization interface [polypeptide binding]; other site 366394007421 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 366394007422 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 366394007423 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 366394007424 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 366394007425 Ferritin-like; Region: Ferritin-like; pfam12902 366394007426 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 366394007427 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 366394007428 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 366394007429 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 366394007430 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 366394007431 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 366394007432 dimer interface [polypeptide binding]; other site 366394007433 PYR/PP interface [polypeptide binding]; other site 366394007434 TPP binding site [chemical binding]; other site 366394007435 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 366394007436 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 366394007437 TPP-binding site [chemical binding]; other site 366394007438 Predicted transcriptional regulator [Transcription]; Region: COG4957 366394007439 Omptin family; Region: Omptin; cl01886 366394007440 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 366394007441 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 366394007442 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 366394007443 nudix motif; other site 366394007444 Integrase core domain; Region: rve; pfam00665 366394007445 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 366394007446 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 366394007447 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 366394007448 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 366394007449 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 366394007450 putative active site [active] 366394007451 putative substrate binding site [chemical binding]; other site 366394007452 putative cosubstrate binding site; other site 366394007453 catalytic site [active] 366394007454 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 366394007455 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 366394007456 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 366394007457 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 366394007458 active site 366394007459 FMN binding site [chemical binding]; other site 366394007460 substrate binding site [chemical binding]; other site 366394007461 3Fe-4S cluster binding site [ion binding]; other site 366394007462 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 366394007463 domain_subunit interface; other site 366394007464 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 366394007465 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 366394007466 putative active site [active] 366394007467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394007468 non-specific DNA binding site [nucleotide binding]; other site 366394007469 salt bridge; other site 366394007470 sequence-specific DNA binding site [nucleotide binding]; other site 366394007471 Cupin domain; Region: Cupin_2; pfam07883 366394007472 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 366394007473 Fic family protein [Function unknown]; Region: COG3177 366394007474 Fic/DOC family; Region: Fic; pfam02661 366394007475 Transposase; Region: HTH_Tnp_1; pfam01527 366394007476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 366394007477 Helix-turn-helix domain; Region: HTH_28; pfam13518 366394007478 Homeodomain-like domain; Region: HTH_32; pfam13565 366394007479 DDE superfamily endonuclease; Region: DDE_3; pfam13358 366394007480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 366394007481 Predicted transcriptional regulator [Transcription]; Region: COG4957 366394007482 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 366394007483 Moco binding site; other site 366394007484 metal coordination site [ion binding]; other site 366394007485 dimerization interface [polypeptide binding]; other site 366394007486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394007487 dimer interface [polypeptide binding]; other site 366394007488 phosphorylation site [posttranslational modification] 366394007489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394007490 ATP binding site [chemical binding]; other site 366394007491 Mg2+ binding site [ion binding]; other site 366394007492 G-X-G motif; other site 366394007493 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 366394007494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394007495 active site 366394007496 phosphorylation site [posttranslational modification] 366394007497 intermolecular recognition site; other site 366394007498 dimerization interface [polypeptide binding]; other site 366394007499 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394007500 DNA binding site [nucleotide binding] 366394007501 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 366394007502 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 366394007503 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 366394007504 Sulfatase; Region: Sulfatase; pfam00884 366394007505 Transposase, Mutator family; Region: Transposase_mut; pfam00872 366394007506 MULE transposase domain; Region: MULE; pfam10551 366394007507 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 366394007508 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 366394007509 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 366394007510 potassium uptake protein; Region: kup; TIGR00794 366394007511 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 366394007512 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 366394007513 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 366394007514 TPP-binding site [chemical binding]; other site 366394007515 Methyltransferase domain; Region: Methyltransf_31; pfam13847 366394007516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394007517 S-adenosylmethionine binding site [chemical binding]; other site 366394007518 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 366394007519 Omptin family; Region: Omptin; cl01886 366394007520 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 366394007521 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 366394007522 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 366394007523 nudix motif; other site 366394007524 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 366394007525 DNA-binding site [nucleotide binding]; DNA binding site 366394007526 RNA-binding motif; other site 366394007527 Protein export membrane protein; Region: SecD_SecF; cl14618 366394007528 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394007529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394007530 non-specific DNA binding site [nucleotide binding]; other site 366394007531 salt bridge; other site 366394007532 sequence-specific DNA binding site [nucleotide binding]; other site 366394007533 acyl carrier protein; Provisional; Region: acpP; PRK00982 366394007534 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 366394007535 oligomerisation interface [polypeptide binding]; other site 366394007536 mobile loop; other site 366394007537 roof hairpin; other site 366394007538 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 366394007539 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 366394007540 ring oligomerisation interface [polypeptide binding]; other site 366394007541 ATP/Mg binding site [chemical binding]; other site 366394007542 stacking interactions; other site 366394007543 hinge regions; other site 366394007544 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 366394007545 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 366394007546 Catalytic site; other site 366394007547 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 366394007548 active site 366394007549 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 366394007550 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 366394007551 active site 366394007552 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 366394007553 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 366394007554 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 366394007555 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 366394007556 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 366394007557 putative active site [active] 366394007558 putative NTP binding site [chemical binding]; other site 366394007559 putative nucleic acid binding site [nucleotide binding]; other site 366394007560 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 366394007561 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 366394007562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394007563 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 366394007564 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 366394007565 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394007566 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 366394007567 Methyltransferase domain; Region: Methyltransf_23; pfam13489 366394007568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394007569 S-adenosylmethionine binding site [chemical binding]; other site 366394007570 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 366394007571 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 366394007572 active site residue [active] 366394007573 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 366394007574 ATP binding site [chemical binding]; other site 366394007575 substrate interface [chemical binding]; other site 366394007576 Ubiquitin-like proteins; Region: UBQ; cl00155 366394007577 charged pocket; other site 366394007578 hydrophobic patch; other site 366394007579 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 366394007580 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 366394007581 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 366394007582 YcaO-like family; Region: YcaO; pfam02624 366394007583 TfuA-like protein; Region: TfuA; pfam07812 366394007584 Uncharacterized conserved protein [Function unknown]; Region: COG1944 366394007585 YcaO-like family; Region: YcaO; pfam02624 366394007586 nif11-like leader peptide domain; Region: ocin_TIGR03798 366394007587 nif11-like leader peptide domain; Region: ocin_TIGR03798 366394007588 nif11-like leader peptide domain; Region: ocin_TIGR03798 366394007589 nif11-like leader peptide domain; Region: ocin_TIGR03798 366394007590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 366394007591 DDE superfamily endonuclease; Region: DDE_3; pfam13358 366394007592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 366394007593 nif11-like leader peptide domain; Region: ocin_TIGR03798 366394007594 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 366394007595 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 366394007596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 366394007597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 366394007598 Transposase; Region: HTH_Tnp_1; pfam01527 366394007599 putative transposase OrfB; Reviewed; Region: PHA02517 366394007600 HTH-like domain; Region: HTH_21; pfam13276 366394007601 Integrase core domain; Region: rve; pfam00665 366394007602 Integrase core domain; Region: rve_3; pfam13683 366394007603 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 366394007604 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 366394007605 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 366394007606 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 366394007607 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 366394007608 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394007609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394007610 salt bridge; other site 366394007611 non-specific DNA binding site [nucleotide binding]; other site 366394007612 sequence-specific DNA binding site [nucleotide binding]; other site 366394007613 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 366394007614 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 366394007615 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 366394007616 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394007617 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394007618 metal binding site [ion binding]; metal-binding site 366394007619 active site 366394007620 I-site; other site 366394007621 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 366394007622 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 366394007623 Amb_all domain; Region: Amb_all; smart00656 366394007624 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 366394007625 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 366394007626 active site 366394007627 zinc binding site [ion binding]; other site 366394007628 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 366394007629 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 366394007630 NAD(P) binding site [chemical binding]; other site 366394007631 catalytic residues [active] 366394007632 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 366394007633 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 366394007634 Walker A motif; other site 366394007635 ATP binding site [chemical binding]; other site 366394007636 Walker B motif; other site 366394007637 two-component response regulator VirG; Provisional; Region: PRK13856 366394007638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394007639 active site 366394007640 phosphorylation site [posttranslational modification] 366394007641 intermolecular recognition site; other site 366394007642 dimerization interface [polypeptide binding]; other site 366394007643 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394007644 DNA binding site [nucleotide binding] 366394007645 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 366394007646 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 366394007647 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 366394007648 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 366394007649 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 366394007650 type IV secretion system protein VirB11; Provisional; Region: PRK13851 366394007651 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 366394007652 Walker A motif; other site 366394007653 hexamer interface [polypeptide binding]; other site 366394007654 ATP binding site [chemical binding]; other site 366394007655 Walker B motif; other site 366394007656 type IV secretion system protein VirB10; Provisional; Region: PRK13855 366394007657 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 366394007658 VirB7 interaction site; other site 366394007659 type IV secretion system protein VirB8; Provisional; Region: PRK13865 366394007660 type IV secretion system lipoprotein VirB7; Provisional; Region: PRK13859 366394007661 type IV secretion system protein VirB6; Provisional; Region: PRK13852 366394007662 type IV secretion system protein VirB5; Provisional; Region: PRK13860 366394007663 Domain of unknown function (DUF4141); Region: DUF4141; pfam13605 366394007664 type IV secretion system protein VirB4; Provisional; Region: PRK13853 366394007665 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 366394007666 type IV secretion system protein VirB3; Provisional; Region: PRK13854 366394007667 type IV secretion system pilin subunit VirB2; Provisional; Region: PRK13857 366394007668 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 366394007669 N-acetyl-D-glucosamine binding site [chemical binding]; other site 366394007670 catalytic residue [active] 366394007671 Homeodomain-like domain; Region: HTH_23; pfam13384 366394007672 Winged helix-turn helix; Region: HTH_29; pfam13551 366394007673 Homeodomain-like domain; Region: HTH_32; pfam13565 366394007674 DDE superfamily endonuclease; Region: DDE_3; pfam13358 366394007675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 366394007676 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 366394007677 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 366394007678 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 366394007679 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 366394007680 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 366394007681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 366394007682 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 366394007683 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 366394007684 glutaminase active site [active] 366394007685 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 366394007686 dimer interface [polypeptide binding]; other site 366394007687 active site 366394007688 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 366394007689 dimer interface [polypeptide binding]; other site 366394007690 active site 366394007691 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 366394007692 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394007693 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 366394007694 Protein export membrane protein; Region: SecD_SecF; cl14618 366394007695 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 366394007696 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 366394007697 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 366394007698 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394007699 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394007700 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 366394007701 putative substrate binding pocket [chemical binding]; other site 366394007702 putative dimerization interface [polypeptide binding]; other site 366394007703 Nodulation protein A (NodA); Region: NodA; pfam02474 366394007704 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 366394007705 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 366394007706 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 366394007707 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 366394007708 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 366394007709 DXD motif; other site 366394007710 nodulation factor exporter subunit NodI; Provisional; Region: PRK13536 366394007711 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 366394007712 Walker A/P-loop; other site 366394007713 ATP binding site [chemical binding]; other site 366394007714 Q-loop/lid; other site 366394007715 ABC transporter signature motif; other site 366394007716 Walker B; other site 366394007717 D-loop; other site 366394007718 H-loop/switch region; other site 366394007719 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 366394007720 ABC-2 type transporter, NodJ family; Region: nodJ; TIGR01291 366394007721 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 366394007722 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 366394007723 CysD dimerization site [polypeptide binding]; other site 366394007724 G1 box; other site 366394007725 putative GEF interaction site [polypeptide binding]; other site 366394007726 GTP/Mg2+ binding site [chemical binding]; other site 366394007727 Switch I region; other site 366394007728 G2 box; other site 366394007729 G3 box; other site 366394007730 Switch II region; other site 366394007731 G4 box; other site 366394007732 G5 box; other site 366394007733 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 366394007734 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 366394007735 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 366394007736 ligand-binding site [chemical binding]; other site 366394007737 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 366394007738 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 366394007739 Active Sites [active] 366394007740 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 366394007741 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 366394007742 NAD(P) binding site [chemical binding]; other site 366394007743 homotetramer interface [polypeptide binding]; other site 366394007744 homodimer interface [polypeptide binding]; other site 366394007745 active site 366394007746 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 366394007747 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 366394007748 dimer interface [polypeptide binding]; other site 366394007749 active site 366394007750 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 366394007751 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 366394007752 Transposase; Region: HTH_Tnp_1; pfam01527 366394007753 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 366394007754 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 366394007755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394007756 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 366394007757 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 366394007758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394007759 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 366394007760 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 366394007761 Int/Topo IB signature motif; other site 366394007762 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394007763 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394007764 The C-terminal substrate binding of LysR-type symbiotic regulator SyrM, which activates expression of nodulation gene NodD3, contains the type 2 periplasmic binding fold; Region: PBP2_SyrM; cd08467 366394007765 putative substrate binding pocket [chemical binding]; other site 366394007766 putative dimerization interface [polypeptide binding]; other site 366394007767 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394007768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394007769 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 366394007770 putative substrate binding pocket [chemical binding]; other site 366394007771 putative dimerization interface [polypeptide binding]; other site 366394007772 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394007773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394007774 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394007775 Exopolysaccharide production repressor; Region: SyrA; pfam11089 366394007776 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 366394007777 Rop-like; Region: Rop-like; pfam05082 366394007778 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 366394007779 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 366394007780 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 366394007781 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 366394007782 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 366394007783 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 366394007784 MoFe protein beta/alpha subunit interactions; other site 366394007785 Beta subunit P cluster binding residues; other site 366394007786 MoFe protein beta subunit/Fe protein contacts; other site 366394007787 MoFe protein dimer/ dimer interactions; other site 366394007788 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 366394007789 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 366394007790 MoFe protein alpha/beta subunit interactions; other site 366394007791 Alpha subunit P cluster binding residues; other site 366394007792 FeMoco binding residues [chemical binding]; other site 366394007793 MoFe protein alpha subunit/Fe protein contacts; other site 366394007794 MoFe protein dimer/ dimer interactions; other site 366394007795 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 366394007796 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 366394007797 Nucleotide-binding sites [chemical binding]; other site 366394007798 Walker A motif; other site 366394007799 Switch I region of nucleotide binding site; other site 366394007800 Fe4S4 binding sites [ion binding]; other site 366394007801 Switch II region of nucleotide binding site; other site 366394007802 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 366394007803 Ligand binding site [chemical binding]; other site 366394007804 Electron transfer flavoprotein domain; Region: ETF; pfam01012 366394007805 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 366394007806 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 366394007807 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 366394007808 oxidoreductase; Provisional; Region: PRK10015 366394007809 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 366394007810 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 366394007811 Nif-specific regulatory protein; Region: nifA; TIGR01817 366394007812 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 366394007813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394007814 Walker A motif; other site 366394007815 ATP binding site [chemical binding]; other site 366394007816 Walker B motif; other site 366394007817 arginine finger; other site 366394007818 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 366394007819 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 366394007820 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 366394007821 FeS/SAM binding site; other site 366394007822 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 366394007823 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 366394007824 Nitrogen fixation protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NifU; COG5554 366394007825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394007826 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394007827 non-specific DNA binding site [nucleotide binding]; other site 366394007828 salt bridge; other site 366394007829 sequence-specific DNA binding site [nucleotide binding]; other site 366394007830 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394007831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394007832 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394007833 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 366394007834 HTH-like domain; Region: HTH_21; pfam13276 366394007835 Integrase core domain; Region: rve; pfam00665 366394007836 Integrase core domain; Region: rve_3; pfam13683 366394007837 Transposase; Region: HTH_Tnp_1; pfam01527 366394007838 Transposase; Region: HTH_Tnp_1; cl17663 366394007839 succinic semialdehyde dehydrogenase; Region: PLN02278 366394007840 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 366394007841 tetramerization interface [polypeptide binding]; other site 366394007842 NAD(P) binding site [chemical binding]; other site 366394007843 catalytic residues [active] 366394007844 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394007845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394007846 Walker A/P-loop; other site 366394007847 ATP binding site [chemical binding]; other site 366394007848 Q-loop/lid; other site 366394007849 ABC transporter signature motif; other site 366394007850 Walker B; other site 366394007851 D-loop; other site 366394007852 H-loop/switch region; other site 366394007853 TOBE domain; Region: TOBE_2; pfam08402 366394007854 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394007855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394007856 dimer interface [polypeptide binding]; other site 366394007857 conserved gate region; other site 366394007858 putative PBP binding loops; other site 366394007859 ABC-ATPase subunit interface; other site 366394007860 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 366394007861 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 366394007862 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394007863 NIPSNAP; Region: NIPSNAP; pfam07978 366394007864 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 366394007865 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 366394007866 NAD(P) binding site [chemical binding]; other site 366394007867 catalytic residues [active] 366394007868 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 366394007869 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 366394007870 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 366394007871 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 366394007872 Amino acid synthesis; Region: AA_synth; pfam06684 366394007873 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394007874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394007875 DNA-binding site [nucleotide binding]; DNA binding site 366394007876 FCD domain; Region: FCD; pfam07729 366394007877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 366394007878 DDE superfamily endonuclease; Region: DDE_3; pfam13358 366394007879 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 366394007880 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 366394007881 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 366394007882 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 366394007883 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 366394007884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394007885 S-adenosylmethionine binding site [chemical binding]; other site 366394007886 maltose O-acetyltransferase; Provisional; Region: PRK10092 366394007887 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 366394007888 active site 366394007889 substrate binding site [chemical binding]; other site 366394007890 trimer interface [polypeptide binding]; other site 366394007891 CoA binding site [chemical binding]; other site 366394007892 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 366394007893 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 366394007894 metal-binding site [ion binding] 366394007895 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 366394007896 Cytochrome c; Region: Cytochrom_C; pfam00034 366394007897 Cytochrome c; Region: Cytochrom_C; pfam00034 366394007898 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 366394007899 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 366394007900 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 366394007901 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 366394007902 Low-spin heme binding site [chemical binding]; other site 366394007903 Putative water exit pathway; other site 366394007904 Binuclear center (active site) [active] 366394007905 Putative proton exit pathway; other site 366394007906 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 366394007907 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 366394007908 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 366394007909 ligand binding site [chemical binding]; other site 366394007910 flexible hinge region; other site 366394007911 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 366394007912 putative switch regulator; other site 366394007913 non-specific DNA interactions [nucleotide binding]; other site 366394007914 DNA binding site [nucleotide binding] 366394007915 sequence specific DNA binding site [nucleotide binding]; other site 366394007916 putative cAMP binding site [chemical binding]; other site 366394007917 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394007918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394007919 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394007920 response regulator FixJ; Provisional; Region: fixJ; PRK09390 366394007921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394007922 active site 366394007923 phosphorylation site [posttranslational modification] 366394007924 intermolecular recognition site; other site 366394007925 dimerization interface [polypeptide binding]; other site 366394007926 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394007927 DNA binding residues [nucleotide binding] 366394007928 dimerization interface [polypeptide binding]; other site 366394007929 PAS domain S-box; Region: sensory_box; TIGR00229 366394007930 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394007931 putative active site [active] 366394007932 heme pocket [chemical binding]; other site 366394007933 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394007934 dimer interface [polypeptide binding]; other site 366394007935 phosphorylation site [posttranslational modification] 366394007936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394007937 ATP binding site [chemical binding]; other site 366394007938 Mg2+ binding site [ion binding]; other site 366394007939 G-X-G motif; other site 366394007940 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 366394007941 pseudoazurin; Region: pseudoazurin; TIGR02375 366394007942 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 366394007943 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 366394007944 ligand binding site [chemical binding]; other site 366394007945 flexible hinge region; other site 366394007946 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 366394007947 putative switch regulator; other site 366394007948 non-specific DNA interactions [nucleotide binding]; other site 366394007949 DNA binding site [nucleotide binding] 366394007950 sequence specific DNA binding site [nucleotide binding]; other site 366394007951 putative cAMP binding site [chemical binding]; other site 366394007952 Uncharacterized conserved protein [Function unknown]; Region: COG1262 366394007953 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 366394007954 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 366394007955 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 366394007956 Multicopper oxidase; Region: Cu-oxidase; pfam00394 366394007957 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 366394007958 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 366394007959 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 366394007960 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 366394007961 Uncharacterized conserved protein [Function unknown]; Region: COG4309 366394007962 LabA_like proteins; Region: LabA_like/DUF88; cl10034 366394007963 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 366394007964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 366394007965 FeS/SAM binding site; other site 366394007966 HemN C-terminal domain; Region: HemN_C; pfam06969 366394007967 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 366394007968 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 366394007969 metal ion-dependent adhesion site (MIDAS); other site 366394007970 MoxR-like ATPases [General function prediction only]; Region: COG0714 366394007971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394007972 Walker A motif; other site 366394007973 ATP binding site [chemical binding]; other site 366394007974 Walker B motif; other site 366394007975 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 366394007976 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 366394007977 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 366394007978 D-pathway; other site 366394007979 K-pathway; other site 366394007980 Binuclear center (active site) [active] 366394007981 Putative proton exit pathway; other site 366394007982 Cytochrome c; Region: Cytochrom_C; pfam00034 366394007983 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 366394007984 Subunit I/III interface [polypeptide binding]; other site 366394007985 NnrU protein; Region: NnrU; cl17713 366394007986 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 366394007987 Flavoprotein; Region: Flavoprotein; pfam02441 366394007988 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 366394007989 SCP-2 sterol transfer family; Region: SCP2; cl01225 366394007990 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 366394007991 Peptidase family U32; Region: Peptidase_U32; pfam01136 366394007992 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 366394007993 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 366394007994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394007995 DNA-binding site [nucleotide binding]; DNA binding site 366394007996 UTRA domain; Region: UTRA; pfam07702 366394007997 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 366394007998 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 366394007999 NAD(P) binding site [chemical binding]; other site 366394008000 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 366394008001 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 366394008002 NAD binding site [chemical binding]; other site 366394008003 dimerization interface [polypeptide binding]; other site 366394008004 product binding site; other site 366394008005 substrate binding site [chemical binding]; other site 366394008006 zinc binding site [ion binding]; other site 366394008007 catalytic residues [active] 366394008008 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394008009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394008010 dimer interface [polypeptide binding]; other site 366394008011 conserved gate region; other site 366394008012 putative PBP binding loops; other site 366394008013 ABC-ATPase subunit interface; other site 366394008014 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 366394008015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394008016 dimer interface [polypeptide binding]; other site 366394008017 conserved gate region; other site 366394008018 putative PBP binding loops; other site 366394008019 ABC-ATPase subunit interface; other site 366394008020 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 366394008021 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394008022 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394008023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394008024 Walker A/P-loop; other site 366394008025 ATP binding site [chemical binding]; other site 366394008026 Q-loop/lid; other site 366394008027 ABC transporter signature motif; other site 366394008028 Walker B; other site 366394008029 D-loop; other site 366394008030 H-loop/switch region; other site 366394008031 TOBE domain; Region: TOBE_2; pfam08402 366394008032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394008033 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 366394008034 NAD(P) binding site [chemical binding]; other site 366394008035 active site 366394008036 histidinol-phosphate aminotransferase; Provisional; Region: PRK05166 366394008037 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394008038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394008039 homodimer interface [polypeptide binding]; other site 366394008040 catalytic residue [active] 366394008041 Uncharacterized conserved protein [Function unknown]; Region: COG5276 366394008042 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 366394008043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394008044 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 366394008045 putative dimerization interface [polypeptide binding]; other site 366394008046 putative substrate binding pocket [chemical binding]; other site 366394008047 osmolarity response regulator; Provisional; Region: ompR; PRK09468 366394008048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394008049 active site 366394008050 phosphorylation site [posttranslational modification] 366394008051 intermolecular recognition site; other site 366394008052 dimerization interface [polypeptide binding]; other site 366394008053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394008054 DNA binding site [nucleotide binding] 366394008055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394008056 dimer interface [polypeptide binding]; other site 366394008057 phosphorylation site [posttranslational modification] 366394008058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394008059 ATP binding site [chemical binding]; other site 366394008060 Mg2+ binding site [ion binding]; other site 366394008061 G-X-G motif; other site 366394008062 Cytochrome c2 [Energy production and conversion]; Region: COG3474 366394008063 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 366394008064 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394008065 catalytic loop [active] 366394008066 iron binding site [ion binding]; other site 366394008067 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 366394008068 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 366394008069 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394008070 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394008071 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 366394008072 putative effector binding pocket; other site 366394008073 dimerization interface [polypeptide binding]; other site 366394008074 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 366394008075 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 366394008076 FMN binding site [chemical binding]; other site 366394008077 active site 366394008078 substrate binding site [chemical binding]; other site 366394008079 catalytic residue [active] 366394008080 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 366394008081 active site 366394008082 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 366394008083 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 366394008084 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 366394008085 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 366394008086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 366394008087 Transposase; Region: HTH_Tnp_1; pfam01527 366394008088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394008089 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 366394008090 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 366394008091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394008092 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 366394008093 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 366394008094 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 366394008095 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 366394008096 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 366394008097 nSec1 interaction sites; other site 366394008098 interdomain interaction site; other site 366394008099 PAS domain; Region: PAS_10; pfam13596 366394008100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394008101 putative active site [active] 366394008102 heme pocket [chemical binding]; other site 366394008103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 366394008104 HWE histidine kinase; Region: HWE_HK; smart00911 366394008105 CheB methylesterase; Region: CheB_methylest; pfam01339 366394008106 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 366394008107 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 366394008108 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 366394008109 Transposase, Mutator family; Region: Transposase_mut; pfam00872 366394008110 Predicted small integral membrane protein [Function unknown]; Region: COG5478 366394008111 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 366394008112 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 366394008113 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 366394008114 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 366394008115 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 366394008116 Trp docking motif [polypeptide binding]; other site 366394008117 dimer interface [polypeptide binding]; other site 366394008118 active site 366394008119 small subunit binding site [polypeptide binding]; other site 366394008120 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 366394008121 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394008122 substrate binding pocket [chemical binding]; other site 366394008123 membrane-bound complex binding site; other site 366394008124 hinge residues; other site 366394008125 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 366394008126 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 366394008127 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 366394008128 Cytochrome c; Region: Cytochrom_C; pfam00034 366394008129 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 366394008130 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 366394008131 D-pathway; other site 366394008132 Putative ubiquinol binding site [chemical binding]; other site 366394008133 Low-spin heme (heme b) binding site [chemical binding]; other site 366394008134 Putative water exit pathway; other site 366394008135 Binuclear center (heme o3/CuB) [ion binding]; other site 366394008136 K-pathway; other site 366394008137 Putative proton exit pathway; other site 366394008138 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 366394008139 Subunit I/III interface [polypeptide binding]; other site 366394008140 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 366394008141 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 366394008142 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 366394008143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394008144 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 366394008145 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 366394008146 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 366394008147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394008148 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 366394008149 Transposase; Region: HTH_Tnp_1; pfam01527 366394008150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 366394008151 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 366394008152 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 366394008153 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 366394008154 Predicted transcriptional regulator [Transcription]; Region: COG4957 366394008155 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394008156 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394008157 non-specific DNA binding site [nucleotide binding]; other site 366394008158 salt bridge; other site 366394008159 sequence-specific DNA binding site [nucleotide binding]; other site 366394008160 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394008161 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394008162 non-specific DNA binding site [nucleotide binding]; other site 366394008163 salt bridge; other site 366394008164 sequence-specific DNA binding site [nucleotide binding]; other site 366394008165 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 366394008166 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 366394008167 P-loop; other site 366394008168 Magnesium ion binding site [ion binding]; other site 366394008169 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 366394008170 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 366394008171 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 366394008172 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 366394008173 dimanganese center [ion binding]; other site 366394008174 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 366394008175 Uncharacterized conserved protein [Function unknown]; Region: COG5361 366394008176 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 366394008177 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 366394008178 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 366394008179 Walker A motif; other site 366394008180 ATP binding site [chemical binding]; other site 366394008181 Walker B motif; other site 366394008182 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 366394008183 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 366394008184 Walker A motif; other site 366394008185 hexamer interface [polypeptide binding]; other site 366394008186 ATP binding site [chemical binding]; other site 366394008187 Walker B motif; other site 366394008188 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 366394008189 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 366394008190 VirB7 interaction site; other site 366394008191 VirB8 protein; Region: VirB8; pfam04335 366394008192 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 366394008193 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 366394008194 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 366394008195 N-acetyl-D-glucosamine binding site [chemical binding]; other site 366394008196 catalytic residue [active] 366394008197 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 366394008198 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 366394008199 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 366394008200 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 366394008201 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 366394008202 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 366394008203 N-acetyl-D-glucosamine binding site [chemical binding]; other site 366394008204 catalytic residue [active] 366394008205 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 366394008206 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 366394008207 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 366394008208 Staphylococcal nuclease homologues; Region: SNc; smart00318 366394008209 Catalytic site; other site 366394008210 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 366394008211 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 366394008212 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 366394008213 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 366394008214 DNA-binding interface [nucleotide binding]; DNA binding site 366394008215 Homeodomain-like domain; Region: HTH_32; pfam13565 366394008216 Integrase core domain; Region: rve; pfam00665 366394008217 Helix-turn-helix domain; Region: HTH_28; pfam13518 366394008218 Winged helix-turn helix; Region: HTH_29; pfam13551 366394008219 Homeodomain-like domain; Region: HTH_32; pfam13565 366394008220 Integrase core domain; Region: rve; pfam00665 366394008221 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 366394008222 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 366394008223 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 366394008224 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 366394008225 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 366394008226 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 366394008227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 366394008228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394008229 dimer interface [polypeptide binding]; other site 366394008230 conserved gate region; other site 366394008231 putative PBP binding loops; other site 366394008232 ABC-ATPase subunit interface; other site 366394008233 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 366394008234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394008235 dimer interface [polypeptide binding]; other site 366394008236 conserved gate region; other site 366394008237 putative PBP binding loops; other site 366394008238 ABC-ATPase subunit interface; other site 366394008239 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 366394008240 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 366394008241 Walker A/P-loop; other site 366394008242 ATP binding site [chemical binding]; other site 366394008243 Q-loop/lid; other site 366394008244 ABC transporter signature motif; other site 366394008245 Walker B; other site 366394008246 D-loop; other site 366394008247 H-loop/switch region; other site 366394008248 Protein of unknown function (DUF736); Region: DUF736; cl02303 366394008249 calcium/proton exchanger; Region: caca2; TIGR00846 366394008250 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 366394008251 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 366394008252 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 366394008253 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 366394008254 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 366394008255 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 366394008256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394008257 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394008258 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394008259 Homeodomain-like domain; Region: HTH_23; pfam13384 366394008260 Winged helix-turn helix; Region: HTH_29; pfam13551 366394008261 Homeodomain-like domain; Region: HTH_32; pfam13565 366394008262 DDE superfamily endonuclease; Region: DDE_3; pfam13358 366394008263 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 366394008264 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 366394008265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394008266 catalytic residue [active] 366394008267 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 366394008268 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394008269 putative DNA binding site [nucleotide binding]; other site 366394008270 putative Zn2+ binding site [ion binding]; other site 366394008271 AsnC family; Region: AsnC_trans_reg; pfam01037 366394008272 Transposase; Region: HTH_Tnp_1; pfam01527 366394008273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 366394008274 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 366394008275 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 366394008276 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 366394008277 Int/Topo IB signature motif; other site 366394008278 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 366394008279 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 366394008280 Int/Topo IB signature motif; other site 366394008281 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 366394008282 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 366394008283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394008284 Walker A motif; other site 366394008285 ATP binding site [chemical binding]; other site 366394008286 Walker B motif; other site 366394008287 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 366394008288 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 366394008289 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 366394008290 putative FMN binding site [chemical binding]; other site 366394008291 NADPH bind site [chemical binding]; other site 366394008292 Condensation domain; Region: Condensation; pfam00668 366394008293 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008294 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 366394008295 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 366394008296 acyl-activating enzyme (AAE) consensus motif; other site 366394008297 AMP binding site [chemical binding]; other site 366394008298 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008299 Condensation domain; Region: Condensation; pfam00668 366394008300 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008301 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 366394008302 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 366394008303 acyl-activating enzyme (AAE) consensus motif; other site 366394008304 AMP binding site [chemical binding]; other site 366394008305 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008306 Condensation domain; Region: Condensation; pfam00668 366394008307 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008308 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 366394008309 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 366394008310 acyl-activating enzyme (AAE) consensus motif; other site 366394008311 AMP binding site [chemical binding]; other site 366394008312 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008313 Condensation domain; Region: Condensation; pfam00668 366394008314 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008315 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 366394008316 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 366394008317 acyl-activating enzyme (AAE) consensus motif; other site 366394008318 AMP binding site [chemical binding]; other site 366394008319 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008320 Condensation domain; Region: Condensation; pfam00668 366394008321 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008322 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 366394008323 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 366394008324 acyl-activating enzyme (AAE) consensus motif; other site 366394008325 AMP binding site [chemical binding]; other site 366394008326 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008327 Condensation domain; Region: Condensation; pfam00668 366394008328 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008329 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 366394008330 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 366394008331 acyl-activating enzyme (AAE) consensus motif; other site 366394008332 AMP binding site [chemical binding]; other site 366394008333 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008334 Condensation domain; Region: Condensation; pfam00668 366394008335 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008336 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 366394008337 acyl-activating enzyme (AAE) consensus motif; other site 366394008338 AMP binding site [chemical binding]; other site 366394008339 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008340 Condensation domain; Region: Condensation; pfam00668 366394008341 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008342 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 366394008343 acyl-activating enzyme (AAE) consensus motif; other site 366394008344 AMP binding site [chemical binding]; other site 366394008345 Thioesterase domain; Region: Thioesterase; pfam00975 366394008346 N-terminal formyl transferase catalytic core domain of NRPS_like proteins, one of the proteins involved in the synthesis of Oxazolomycin; Region: FMT_core_NRPS_like; cd08649 366394008347 putative active site [active] 366394008348 putative substrate binding site [chemical binding]; other site 366394008349 putative cosubstrate binding site; other site 366394008350 catalytic site [active] 366394008351 Condensation domain; Region: Condensation; pfam00668 366394008352 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008353 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 366394008354 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 366394008355 acyl-activating enzyme (AAE) consensus motif; other site 366394008356 AMP binding site [chemical binding]; other site 366394008357 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008358 Condensation domain; Region: Condensation; pfam00668 366394008359 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 366394008360 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 366394008361 acyl-activating enzyme (AAE) consensus motif; other site 366394008362 AMP binding site [chemical binding]; other site 366394008363 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008364 Condensation domain; Region: Condensation; pfam00668 366394008365 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008366 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 366394008367 acyl-activating enzyme (AAE) consensus motif; other site 366394008368 AMP binding site [chemical binding]; other site 366394008369 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008370 Condensation domain; Region: Condensation; pfam00668 366394008371 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008372 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 366394008373 acyl-activating enzyme (AAE) consensus motif; other site 366394008374 AMP binding site [chemical binding]; other site 366394008375 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008376 Condensation domain; Region: Condensation; pfam00668 366394008377 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008378 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 366394008379 acyl-activating enzyme (AAE) consensus motif; other site 366394008380 AMP binding site [chemical binding]; other site 366394008381 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008382 Condensation domain; Region: Condensation; pfam00668 366394008383 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008384 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 366394008385 acyl-activating enzyme (AAE) consensus motif; other site 366394008386 AMP binding site [chemical binding]; other site 366394008387 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008388 Condensation domain; Region: Condensation; pfam00668 366394008389 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008390 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 366394008391 acyl-activating enzyme (AAE) consensus motif; other site 366394008392 AMP binding site [chemical binding]; other site 366394008393 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008394 Condensation domain; Region: Condensation; pfam00668 366394008395 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 366394008396 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 366394008397 acyl-activating enzyme (AAE) consensus motif; other site 366394008398 AMP binding site [chemical binding]; other site 366394008399 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 366394008400 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394008401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394008402 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 366394008403 putative effector binding pocket; other site 366394008404 dimerization interface [polypeptide binding]; other site 366394008405 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 366394008406 Homeodomain-like domain; Region: HTH_23; pfam13384 366394008407 Winged helix-turn helix; Region: HTH_29; pfam13551 366394008408 Homeodomain-like domain; Region: HTH_32; pfam13565 366394008409 DDE superfamily endonuclease; Region: DDE_3; pfam13358 366394008410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 366394008411 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 366394008412 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 366394008413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 366394008414 Protein of unknown function (DUF736); Region: DUF736; cl02303 366394008415 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 366394008416 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 366394008417 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 366394008418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394008419 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 366394008420 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 366394008421 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 366394008422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394008423 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 366394008424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 366394008425 Transposase; Region: HTH_Tnp_1; pfam01527 366394008426 Autoinducer synthetase; Region: Autoind_synth; cl17404 366394008427 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 366394008428 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 366394008429 DNA binding residues [nucleotide binding] 366394008430 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 366394008431 P-loop; other site 366394008432 Magnesium ion binding site [ion binding]; other site 366394008433 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 366394008434 Magnesium ion binding site [ion binding]; other site 366394008435 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 366394008436 ParB-like nuclease domain; Region: ParBc; pfam02195 366394008437 replication initiation protein RepC; Provisional; Region: PRK13824 366394008438 Replication protein C N-terminal domain; Region: RP-C; pfam03428 366394008439 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 366394008440 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 366394008441 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 366394008442 putative active site [active] 366394008443 homotetrameric interface [polypeptide binding]; other site 366394008444 metal binding site [ion binding]; metal-binding site 366394008445 Restriction endonuclease; Region: Mrr_cat; pfam04471 366394008446 Restriction endonuclease; Region: Mrr_cat; pfam04471 366394008447 TIR domain; Region: TIR_2; cl17458 366394008448 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 366394008449 5' RNA guide strand anchoring site; other site 366394008450 active site 366394008451 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 366394008452 HTH-like domain; Region: HTH_21; pfam13276 366394008453 Integrase core domain; Region: rve; pfam00665 366394008454 Integrase core domain; Region: rve_3; pfam13683 366394008455 Transposase; Region: HTH_Tnp_1; pfam01527 366394008456 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 366394008457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 366394008458 Transposase; Region: HTH_Tnp_1; pfam01527 366394008459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394008460 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 366394008461 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 366394008462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394008463 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 366394008464 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 366394008465 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 366394008466 HTH-like domain; Region: HTH_21; pfam13276 366394008467 Integrase core domain; Region: rve; pfam00665 366394008468 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 366394008469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394008470 Walker A motif; other site 366394008471 ATP binding site [chemical binding]; other site 366394008472 Walker B motif; other site 366394008473 arginine finger; other site 366394008474 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 366394008475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 366394008476 DNA-binding interface [nucleotide binding]; DNA binding site 366394008477 Integrase core domain; Region: rve; pfam00665 366394008478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394008479 active site 366394008480 phosphorylation site [posttranslational modification] 366394008481 intermolecular recognition site; other site 366394008482 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 366394008483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394008484 active site 366394008485 phosphorylation site [posttranslational modification] 366394008486 intermolecular recognition site; other site 366394008487 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 366394008488 catalytic residue [active] 366394008489 Domain of unknown function (DUF955); Region: DUF955; cl01076 366394008490 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 366394008491 active site 366394008492 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 366394008493 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 366394008494 DnaA N-terminal domain; Region: DnaA_N; pfam11638 366394008495 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 366394008496 Bacterial dnaA protein; Region: Bac_DnaA; pfam00308 366394008497 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 366394008498 DnaA box-binding interface [nucleotide binding]; other site 366394008499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 366394008500 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 366394008501 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 366394008502 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 366394008503 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 366394008504 putative hydrophobic ligand binding site [chemical binding]; other site 366394008505 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 366394008506 SnoaL-like domain; Region: SnoaL_3; pfam13474 366394008507 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 366394008508 putative dimer interface [polypeptide binding]; other site 366394008509 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394008510 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 366394008511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 366394008512 FeS/SAM binding site; other site 366394008513 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 366394008514 active site 366394008515 dimerization interface [polypeptide binding]; other site 366394008516 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394008517 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 366394008518 putative metal binding site [ion binding]; other site 366394008519 ribonuclease PH; Reviewed; Region: rph; PRK00173 366394008520 Ribonuclease PH; Region: RNase_PH_bact; cd11362 366394008521 hexamer interface [polypeptide binding]; other site 366394008522 active site 366394008523 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 366394008524 heat shock protein GrpE; Provisional; Region: PRK14141 366394008525 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 366394008526 dimer interface [polypeptide binding]; other site 366394008527 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 366394008528 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 366394008529 active site 366394008530 phosphorylation site [posttranslational modification] 366394008531 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 366394008532 30S subunit binding site; other site 366394008533 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 366394008534 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 366394008535 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 366394008536 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 366394008537 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 366394008538 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 366394008539 Walker A/P-loop; other site 366394008540 ATP binding site [chemical binding]; other site 366394008541 Q-loop/lid; other site 366394008542 ABC transporter signature motif; other site 366394008543 Walker B; other site 366394008544 D-loop; other site 366394008545 H-loop/switch region; other site 366394008546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 366394008547 OstA-like protein; Region: OstA; pfam03968 366394008548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 366394008549 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 366394008550 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 366394008551 tandem repeat interface [polypeptide binding]; other site 366394008552 oligomer interface [polypeptide binding]; other site 366394008553 active site residues [active] 366394008554 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 366394008555 IHF dimer interface [polypeptide binding]; other site 366394008556 IHF - DNA interface [nucleotide binding]; other site 366394008557 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 366394008558 putative hydrophobic ligand binding site [chemical binding]; other site 366394008559 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 366394008560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394008561 S-adenosylmethionine binding site [chemical binding]; other site 366394008562 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 366394008563 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 366394008564 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 366394008565 lipoprotein signal peptidase; Provisional; Region: PRK14795 366394008566 lipoprotein signal peptidase; Provisional; Region: PRK14787 366394008567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394008568 dimer interface [polypeptide binding]; other site 366394008569 phosphorylation site [posttranslational modification] 366394008570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394008571 ATP binding site [chemical binding]; other site 366394008572 Mg2+ binding site [ion binding]; other site 366394008573 G-X-G motif; other site 366394008574 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 366394008575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394008576 active site 366394008577 phosphorylation site [posttranslational modification] 366394008578 intermolecular recognition site; other site 366394008579 dimerization interface [polypeptide binding]; other site 366394008580 Putative hemolysin [General function prediction only]; Region: COG3176 366394008581 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 366394008582 Malic enzyme, N-terminal domain; Region: malic; pfam00390 366394008583 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 366394008584 putative NAD(P) binding site [chemical binding]; other site 366394008585 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 366394008586 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 366394008587 MutS domain I; Region: MutS_I; pfam01624 366394008588 MutS domain II; Region: MutS_II; pfam05188 366394008589 MutS domain III; Region: MutS_III; pfam05192 366394008590 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 366394008591 Walker A/P-loop; other site 366394008592 ATP binding site [chemical binding]; other site 366394008593 Q-loop/lid; other site 366394008594 ABC transporter signature motif; other site 366394008595 Walker B; other site 366394008596 D-loop; other site 366394008597 H-loop/switch region; other site 366394008598 PII uridylyl-transferase; Provisional; Region: PRK05092 366394008599 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 366394008600 metal binding triad; other site 366394008601 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 366394008602 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 366394008603 Zn2+ binding site [ion binding]; other site 366394008604 Mg2+ binding site [ion binding]; other site 366394008605 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 366394008606 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 366394008607 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 366394008608 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 366394008609 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394008610 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 366394008611 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 366394008612 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 366394008613 active site 366394008614 HIGH motif; other site 366394008615 dimer interface [polypeptide binding]; other site 366394008616 KMSKS motif; other site 366394008617 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 366394008618 Ligand Binding Site [chemical binding]; other site 366394008619 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 366394008620 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 366394008621 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 366394008622 Glycoprotease family; Region: Peptidase_M22; pfam00814 366394008623 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 366394008624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394008625 Coenzyme A binding pocket [chemical binding]; other site 366394008626 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 366394008627 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 366394008628 putative acyl-acceptor binding pocket; other site 366394008629 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 366394008630 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 366394008631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 366394008632 FeS/SAM binding site; other site 366394008633 TRAM domain; Region: TRAM; pfam01938 366394008634 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 366394008635 PhoH-like protein; Region: PhoH; pfam02562 366394008636 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 366394008637 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 366394008638 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 366394008639 Transporter associated domain; Region: CorC_HlyC; smart01091 366394008640 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 366394008641 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 366394008642 putative active site [active] 366394008643 catalytic triad [active] 366394008644 putative dimer interface [polypeptide binding]; other site 366394008645 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394008646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394008647 non-specific DNA binding site [nucleotide binding]; other site 366394008648 salt bridge; other site 366394008649 sequence-specific DNA binding site [nucleotide binding]; other site 366394008650 S-adenosylmethionine synthetase; Validated; Region: PRK05250 366394008651 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 366394008652 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 366394008653 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 366394008654 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 366394008655 Uncharacterized small protein [Function unknown]; Region: COG5568 366394008656 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 366394008657 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 366394008658 putative dimer interface [polypeptide binding]; other site 366394008659 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 366394008660 active site 366394008661 tetramer interface [polypeptide binding]; other site 366394008662 Cache domain; Region: Cache_1; pfam02743 366394008663 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 366394008664 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 366394008665 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 366394008666 dimer interface [polypeptide binding]; other site 366394008667 putative CheW interface [polypeptide binding]; other site 366394008668 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 366394008669 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 366394008670 substrate binding site [chemical binding]; other site 366394008671 dimer interface [polypeptide binding]; other site 366394008672 ATP binding site [chemical binding]; other site 366394008673 RmuC family; Region: RmuC; pfam02646 366394008674 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 366394008675 active site 366394008676 catalytic residues [active] 366394008677 metal binding site [ion binding]; metal-binding site 366394008678 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 366394008679 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 366394008680 putative active site [active] 366394008681 substrate binding site [chemical binding]; other site 366394008682 putative cosubstrate binding site; other site 366394008683 catalytic site [active] 366394008684 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 366394008685 substrate binding site [chemical binding]; other site 366394008686 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 366394008687 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 366394008688 dimerization interface 3.5A [polypeptide binding]; other site 366394008689 active site 366394008690 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 366394008691 CHASE2 domain; Region: CHASE2; pfam05226 366394008692 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394008693 cyclase homology domain; Region: CHD; cd07302 366394008694 nucleotidyl binding site; other site 366394008695 metal binding site [ion binding]; metal-binding site 366394008696 dimer interface [polypeptide binding]; other site 366394008697 FecR protein; Region: FecR; pfam04773 366394008698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394008699 TPR motif; other site 366394008700 TPR repeat; Region: TPR_11; pfam13414 366394008701 binding surface 366394008702 TPR repeat; Region: TPR_11; pfam13414 366394008703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394008704 binding surface 366394008705 TPR motif; other site 366394008706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394008707 binding surface 366394008708 Tetratricopeptide repeat; Region: TPR_16; pfam13432 366394008709 TPR motif; other site 366394008710 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 366394008711 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 366394008712 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 366394008713 metal binding site [ion binding]; metal-binding site 366394008714 dimer interface [polypeptide binding]; other site 366394008715 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 366394008716 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 366394008717 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 366394008718 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394008719 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 366394008720 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394008721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394008722 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 366394008723 putative effector binding pocket; other site 366394008724 putative dimerization interface [polypeptide binding]; other site 366394008725 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 366394008726 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 366394008727 ATP binding site [chemical binding]; other site 366394008728 Mg++ binding site [ion binding]; other site 366394008729 motif III; other site 366394008730 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 366394008731 nucleotide binding region [chemical binding]; other site 366394008732 ATP-binding site [chemical binding]; other site 366394008733 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 366394008734 RNA binding site [nucleotide binding]; other site 366394008735 Predicted membrane protein [Function unknown]; Region: COG3152 366394008736 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 366394008737 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 366394008738 trimer interface [polypeptide binding]; other site 366394008739 active site 366394008740 substrate binding site [chemical binding]; other site 366394008741 CoA binding site [chemical binding]; other site 366394008742 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 366394008743 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 366394008744 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 366394008745 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 366394008746 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 366394008747 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 366394008748 DNA binding site [nucleotide binding] 366394008749 active site 366394008750 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 366394008751 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 366394008752 tetramer interface [polypeptide binding]; other site 366394008753 active site 366394008754 Mg2+/Mn2+ binding site [ion binding]; other site 366394008755 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 366394008756 homohexameric interface [polypeptide binding]; other site 366394008757 feedback inhibition sensing region; other site 366394008758 carbamate kinase; Reviewed; Region: PRK12686 366394008759 nucleotide binding site [chemical binding]; other site 366394008760 N-acetyl-L-glutamate binding site [chemical binding]; other site 366394008761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 366394008762 Anti-sigma-K factor rskA; Region: RskA; pfam10099 366394008763 Predicted membrane protein [Function unknown]; Region: COG4803 366394008764 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 366394008765 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 366394008766 G1 box; other site 366394008767 GTP/Mg2+ binding site [chemical binding]; other site 366394008768 Switch I region; other site 366394008769 G2 box; other site 366394008770 G3 box; other site 366394008771 Switch II region; other site 366394008772 G4 box; other site 366394008773 G5 box; other site 366394008774 membrane protein insertase; Provisional; Region: PRK01318 366394008775 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 366394008776 ribonuclease P; Reviewed; Region: rnpA; PRK01313 366394008777 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 366394008778 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 366394008779 dimerization interface [polypeptide binding]; other site 366394008780 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 366394008781 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 366394008782 dimer interface [polypeptide binding]; other site 366394008783 putative CheW interface [polypeptide binding]; other site 366394008784 Uncharacterized conserved protein [Function unknown]; Region: COG0398 366394008785 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 366394008786 mercuric reductase; Validated; Region: PRK06370 366394008787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 366394008788 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394008789 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 366394008790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394008791 HAMP domain; Region: HAMP; pfam00672 366394008792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394008793 ATP binding site [chemical binding]; other site 366394008794 Mg2+ binding site [ion binding]; other site 366394008795 G-X-G motif; other site 366394008796 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 366394008797 trimer interface [polypeptide binding]; other site 366394008798 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 366394008799 trimer interface [polypeptide binding]; other site 366394008800 Haemagglutinin; Region: HIM; pfam05662 366394008801 YadA-like C-terminal region; Region: YadA; pfam03895 366394008802 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 366394008803 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 366394008804 putative deacylase active site [active] 366394008805 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 366394008806 Uncharacterized conserved protein [Function unknown]; Region: COG1739 366394008807 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 366394008808 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 366394008809 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 366394008810 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 366394008811 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 366394008812 Glutamate binding site [chemical binding]; other site 366394008813 NAD binding site [chemical binding]; other site 366394008814 catalytic residues [active] 366394008815 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 366394008816 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 366394008817 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 366394008818 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 366394008819 active site 366394008820 metal binding site [ion binding]; metal-binding site 366394008821 hexamer interface [polypeptide binding]; other site 366394008822 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 366394008823 FecR protein; Region: FecR; pfam04773 366394008824 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 366394008825 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 366394008826 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394008827 cyclase homology domain; Region: CHD; cd07302 366394008828 nucleotidyl binding site; other site 366394008829 metal binding site [ion binding]; metal-binding site 366394008830 dimer interface [polypeptide binding]; other site 366394008831 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 366394008832 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 366394008833 ligand binding site [chemical binding]; other site 366394008834 flexible hinge region; other site 366394008835 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 366394008836 putative switch regulator; other site 366394008837 non-specific DNA interactions [nucleotide binding]; other site 366394008838 DNA binding site [nucleotide binding] 366394008839 sequence specific DNA binding site [nucleotide binding]; other site 366394008840 putative cAMP binding site [chemical binding]; other site 366394008841 Predicted membrane protein [Function unknown]; Region: COG2259 366394008842 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 366394008843 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 366394008844 non-specific DNA interactions [nucleotide binding]; other site 366394008845 DNA binding site [nucleotide binding] 366394008846 sequence specific DNA binding site [nucleotide binding]; other site 366394008847 putative cAMP binding site [chemical binding]; other site 366394008848 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 366394008849 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 366394008850 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 366394008851 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 366394008852 ligand binding site [chemical binding]; other site 366394008853 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394008854 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394008855 TM-ABC transporter signature motif; other site 366394008856 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 366394008857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394008858 Walker A/P-loop; other site 366394008859 ATP binding site [chemical binding]; other site 366394008860 Q-loop/lid; other site 366394008861 ABC transporter signature motif; other site 366394008862 Walker B; other site 366394008863 D-loop; other site 366394008864 H-loop/switch region; other site 366394008865 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 366394008866 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 366394008867 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 366394008868 active site 366394008869 substrate binding pocket [chemical binding]; other site 366394008870 dimer interface [polypeptide binding]; other site 366394008871 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 366394008872 active site 366394008873 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 366394008874 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 366394008875 putative substrate binding site [chemical binding]; other site 366394008876 putative ATP binding site [chemical binding]; other site 366394008877 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 366394008878 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 366394008879 active site 366394008880 dimer interface [polypeptide binding]; other site 366394008881 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 366394008882 dimer interface [polypeptide binding]; other site 366394008883 active site 366394008884 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 366394008885 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 366394008886 acyl-activating enzyme (AAE) consensus motif; other site 366394008887 putative AMP binding site [chemical binding]; other site 366394008888 putative active site [active] 366394008889 putative CoA binding site [chemical binding]; other site 366394008890 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 366394008891 Domain of unknown function DUF20; Region: UPF0118; pfam01594 366394008892 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 366394008893 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 366394008894 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 366394008895 putative acyl-acceptor binding pocket; other site 366394008896 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 366394008897 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 366394008898 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 366394008899 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 366394008900 FMN binding site [chemical binding]; other site 366394008901 substrate binding site [chemical binding]; other site 366394008902 putative catalytic residue [active] 366394008903 Uncharacterized conserved protein [Function unknown]; Region: COG2326 366394008904 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 366394008905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394008906 dimer interface [polypeptide binding]; other site 366394008907 phosphorylation site [posttranslational modification] 366394008908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394008909 ATP binding site [chemical binding]; other site 366394008910 Mg2+ binding site [ion binding]; other site 366394008911 G-X-G motif; other site 366394008912 PBP superfamily domain; Region: PBP_like_2; pfam12849 366394008913 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 366394008914 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 366394008915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394008916 dimer interface [polypeptide binding]; other site 366394008917 conserved gate region; other site 366394008918 putative PBP binding loops; other site 366394008919 ABC-ATPase subunit interface; other site 366394008920 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 366394008921 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 366394008922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394008923 dimer interface [polypeptide binding]; other site 366394008924 conserved gate region; other site 366394008925 putative PBP binding loops; other site 366394008926 ABC-ATPase subunit interface; other site 366394008927 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 366394008928 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 366394008929 Walker A/P-loop; other site 366394008930 ATP binding site [chemical binding]; other site 366394008931 Q-loop/lid; other site 366394008932 ABC transporter signature motif; other site 366394008933 Walker B; other site 366394008934 D-loop; other site 366394008935 H-loop/switch region; other site 366394008936 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 366394008937 PhoU domain; Region: PhoU; pfam01895 366394008938 PhoU domain; Region: PhoU; pfam01895 366394008939 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 366394008940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394008941 active site 366394008942 phosphorylation site [posttranslational modification] 366394008943 intermolecular recognition site; other site 366394008944 dimerization interface [polypeptide binding]; other site 366394008945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394008946 DNA binding site [nucleotide binding] 366394008947 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 366394008948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394008949 Coenzyme A binding pocket [chemical binding]; other site 366394008950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 366394008951 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 366394008952 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 366394008953 inhibitor-cofactor binding pocket; inhibition site 366394008954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394008955 catalytic residue [active] 366394008956 ornithine carbamoyltransferase; Provisional; Region: PRK00779 366394008957 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 366394008958 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 366394008959 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 366394008960 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 366394008961 dimerization interface [polypeptide binding]; other site 366394008962 domain crossover interface; other site 366394008963 redox-dependent activation switch; other site 366394008964 Uncharacterized protein affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism]; Region: ApaG; COG2967 366394008965 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394008966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394008967 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394008968 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 366394008969 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 366394008970 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 366394008971 homodimer interface [polypeptide binding]; other site 366394008972 substrate-cofactor binding pocket; other site 366394008973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394008974 catalytic residue [active] 366394008975 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 366394008976 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 366394008977 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 366394008978 trimer interface [polypeptide binding]; other site 366394008979 active site 366394008980 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 366394008981 trimer interface [polypeptide binding]; other site 366394008982 active site 366394008983 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 366394008984 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394008985 substrate binding pocket [chemical binding]; other site 366394008986 membrane-bound complex binding site; other site 366394008987 hinge residues; other site 366394008988 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 366394008989 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 366394008990 tellurite resistance protein terB; Region: terB; cd07176 366394008991 putative metal binding site [ion binding]; other site 366394008992 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 366394008993 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 366394008994 Catalytic site; other site 366394008995 Predicted transcriptional regulator [Transcription]; Region: COG2932 366394008996 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 366394008997 Catalytic site [active] 366394008998 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 366394008999 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 366394009000 Predicted transcriptional regulators [Transcription]; Region: COG1733 366394009001 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 366394009002 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 366394009003 putative hydrophobic ligand binding site [chemical binding]; other site 366394009004 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 366394009005 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 366394009006 substrate binding site [chemical binding]; other site 366394009007 oxyanion hole (OAH) forming residues; other site 366394009008 trimer interface [polypeptide binding]; other site 366394009009 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 366394009010 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 366394009011 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 366394009012 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 366394009013 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 366394009014 dimer interface [polypeptide binding]; other site 366394009015 active site 366394009016 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 366394009017 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 366394009018 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 366394009019 FAD binding site [chemical binding]; other site 366394009020 substrate binding site [chemical binding]; other site 366394009021 catalytic residues [active] 366394009022 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 366394009023 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 366394009024 Sel1-like repeats; Region: SEL1; smart00671 366394009025 Sel1-like repeats; Region: SEL1; smart00671 366394009026 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 366394009027 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394009028 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 366394009029 conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186 366394009030 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394009031 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394009032 AsnC family; Region: AsnC_trans_reg; pfam01037 366394009033 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 366394009034 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 366394009035 putative active site [active] 366394009036 putative metal binding site [ion binding]; other site 366394009037 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 366394009038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 366394009039 ATP binding site [chemical binding]; other site 366394009040 putative Mg++ binding site [ion binding]; other site 366394009041 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 366394009042 nucleotide binding region [chemical binding]; other site 366394009043 ATP-binding site [chemical binding]; other site 366394009044 DEAD/H associated; Region: DEAD_assoc; pfam08494 366394009045 Rrf2 family protein; Region: rrf2_super; TIGR00738 366394009046 Transcriptional regulator; Region: Rrf2; pfam02082 366394009047 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 366394009048 Uncharacterized conserved protein [Function unknown]; Region: COG2128 366394009049 Uncharacterized conserved protein [Function unknown]; Region: COG1284 366394009050 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 366394009051 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 366394009052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394009053 S-adenosylmethionine binding site [chemical binding]; other site 366394009054 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 366394009055 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 366394009056 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 366394009057 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 366394009058 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 366394009059 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 366394009060 quinone interaction residues [chemical binding]; other site 366394009061 active site 366394009062 catalytic residues [active] 366394009063 FMN binding site [chemical binding]; other site 366394009064 substrate binding site [chemical binding]; other site 366394009065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 366394009066 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 366394009067 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394009068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394009069 active site 366394009070 phosphorylation site [posttranslational modification] 366394009071 intermolecular recognition site; other site 366394009072 dimerization interface [polypeptide binding]; other site 366394009073 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394009074 DNA binding residues [nucleotide binding] 366394009075 dimerization interface [polypeptide binding]; other site 366394009076 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 366394009077 Na binding site [ion binding]; other site 366394009078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394009079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394009080 dimer interface [polypeptide binding]; other site 366394009081 phosphorylation site [posttranslational modification] 366394009082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394009083 ATP binding site [chemical binding]; other site 366394009084 Mg2+ binding site [ion binding]; other site 366394009085 G-X-G motif; other site 366394009086 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 366394009087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394009088 active site 366394009089 phosphorylation site [posttranslational modification] 366394009090 intermolecular recognition site; other site 366394009091 dimerization interface [polypeptide binding]; other site 366394009092 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 366394009093 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 366394009094 aspartate aminotransferase; Provisional; Region: PRK06108 366394009095 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394009096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394009097 homodimer interface [polypeptide binding]; other site 366394009098 catalytic residue [active] 366394009099 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 366394009100 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 366394009101 NAD binding site [chemical binding]; other site 366394009102 homodimer interface [polypeptide binding]; other site 366394009103 active site 366394009104 substrate binding site [chemical binding]; other site 366394009105 chorismate mutase related enzymes; Region: CM-like; TIGR01803 366394009106 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 366394009107 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 366394009108 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 366394009109 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 366394009110 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 366394009111 metal binding site [ion binding]; metal-binding site 366394009112 putative dimer interface [polypeptide binding]; other site 366394009113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394009114 dimer interface [polypeptide binding]; other site 366394009115 conserved gate region; other site 366394009116 putative PBP binding loops; other site 366394009117 ABC-ATPase subunit interface; other site 366394009118 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 366394009119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394009120 dimer interface [polypeptide binding]; other site 366394009121 conserved gate region; other site 366394009122 putative PBP binding loops; other site 366394009123 ABC-ATPase subunit interface; other site 366394009124 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394009125 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 366394009126 substrate binding pocket [chemical binding]; other site 366394009127 membrane-bound complex binding site; other site 366394009128 hinge residues; other site 366394009129 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 366394009130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394009131 Walker A/P-loop; other site 366394009132 ATP binding site [chemical binding]; other site 366394009133 Q-loop/lid; other site 366394009134 ABC transporter signature motif; other site 366394009135 Walker B; other site 366394009136 D-loop; other site 366394009137 H-loop/switch region; other site 366394009138 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 366394009139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394009140 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 366394009141 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 366394009142 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394009143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394009144 homodimer interface [polypeptide binding]; other site 366394009145 catalytic residue [active] 366394009146 hypothetical protein; Provisional; Region: PRK07524 366394009147 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 366394009148 PYR/PP interface [polypeptide binding]; other site 366394009149 dimer interface [polypeptide binding]; other site 366394009150 TPP binding site [chemical binding]; other site 366394009151 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 366394009152 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 366394009153 TPP-binding site [chemical binding]; other site 366394009154 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 366394009155 Protein export membrane protein; Region: SecD_SecF; cl14618 366394009156 Protein export membrane protein; Region: SecD_SecF; pfam02355 366394009157 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394009158 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394009159 Walker A/P-loop; other site 366394009160 ATP binding site [chemical binding]; other site 366394009161 Q-loop/lid; other site 366394009162 ABC transporter signature motif; other site 366394009163 Walker B; other site 366394009164 D-loop; other site 366394009165 H-loop/switch region; other site 366394009166 TOBE domain; Region: TOBE_2; pfam08402 366394009167 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394009168 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394009169 DNA-binding site [nucleotide binding]; DNA binding site 366394009170 FCD domain; Region: FCD; pfam07729 366394009171 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 366394009172 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394009173 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394009174 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 366394009175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394009176 dimer interface [polypeptide binding]; other site 366394009177 conserved gate region; other site 366394009178 putative PBP binding loops; other site 366394009179 ABC-ATPase subunit interface; other site 366394009180 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394009181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 366394009182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394009183 putative PBP binding loops; other site 366394009184 ABC-ATPase subunit interface; other site 366394009185 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 366394009186 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 366394009187 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394009188 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394009189 Rrf2 family protein; Region: rrf2_super; TIGR00738 366394009190 Transcriptional regulator; Region: Rrf2; pfam02082 366394009191 KpsF/GutQ family protein; Region: kpsF; TIGR00393 366394009192 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 366394009193 putative active site [active] 366394009194 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 366394009195 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 366394009196 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 366394009197 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 366394009198 Sulfatase; Region: Sulfatase; cl17466 366394009199 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 366394009200 putative NAD(P) binding site [chemical binding]; other site 366394009201 short chain dehydrogenase; Provisional; Region: PRK06181 366394009202 homotetramer interface [polypeptide binding]; other site 366394009203 active site 366394009204 homodimer interface [polypeptide binding]; other site 366394009205 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 366394009206 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 366394009207 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 366394009208 catalytic residue [active] 366394009209 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 366394009210 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 366394009211 active site 366394009212 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 366394009213 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 366394009214 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 366394009215 Enoylreductase; Region: PKS_ER; smart00829 366394009216 NAD(P) binding site [chemical binding]; other site 366394009217 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 366394009218 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 366394009219 putative NADP binding site [chemical binding]; other site 366394009220 active site 366394009221 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 366394009222 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 366394009223 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 366394009224 SLBB domain; Region: SLBB; pfam10531 366394009225 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 366394009226 Isochorismatase family; Region: Isochorismatase; pfam00857 366394009227 catalytic triad [active] 366394009228 metal binding site [ion binding]; metal-binding site 366394009229 conserved cis-peptide bond; other site 366394009230 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 366394009231 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 366394009232 active site 366394009233 Transglycosylase; Region: Transgly; pfam00912 366394009234 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 366394009235 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 366394009236 BA14K-like protein; Region: BA14K; pfam07886 366394009237 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 366394009238 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 366394009239 hinge; other site 366394009240 active site 366394009241 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 366394009242 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 366394009243 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 366394009244 NAD binding site [chemical binding]; other site 366394009245 dimerization interface [polypeptide binding]; other site 366394009246 product binding site; other site 366394009247 substrate binding site [chemical binding]; other site 366394009248 zinc binding site [ion binding]; other site 366394009249 catalytic residues [active] 366394009250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5328 366394009251 Low molecular weight phosphatase family; Region: LMWPc; cd00115 366394009252 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 366394009253 active site 366394009254 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 366394009255 rRNA binding site [nucleotide binding]; other site 366394009256 predicted 30S ribosome binding site; other site 366394009257 Maf-like protein; Region: Maf; pfam02545 366394009258 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 366394009259 active site 366394009260 dimer interface [polypeptide binding]; other site 366394009261 zinc-binding protein; Provisional; Region: PRK01343 366394009262 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 366394009263 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 366394009264 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 366394009265 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 366394009266 putative deacylase active site [active] 366394009267 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952 366394009268 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 366394009269 short chain dehydrogenase; Validated; Region: PRK08324 366394009270 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 366394009271 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 366394009272 putative NAD(P) binding site [chemical binding]; other site 366394009273 active site 366394009274 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 366394009275 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 366394009276 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 366394009277 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 366394009278 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 366394009279 ligand binding site [chemical binding]; other site 366394009280 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394009281 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394009282 Walker A/P-loop; other site 366394009283 ATP binding site [chemical binding]; other site 366394009284 Q-loop/lid; other site 366394009285 ABC transporter signature motif; other site 366394009286 Walker B; other site 366394009287 D-loop; other site 366394009288 H-loop/switch region; other site 366394009289 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394009290 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394009291 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394009292 TM-ABC transporter signature motif; other site 366394009293 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394009294 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394009295 TM-ABC transporter signature motif; other site 366394009296 Uncharacterized conserved protein [Function unknown]; Region: COG3254 366394009297 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 366394009298 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 366394009299 N- and C-terminal domain interface [polypeptide binding]; other site 366394009300 putative active site [active] 366394009301 putative MgATP binding site [chemical binding]; other site 366394009302 putative catalytic site [active] 366394009303 metal binding site [ion binding]; metal-binding site 366394009304 putative carbohydrate binding site [chemical binding]; other site 366394009305 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 366394009306 heme-binding site [chemical binding]; other site 366394009307 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 366394009308 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 366394009309 dimer interface [polypeptide binding]; other site 366394009310 putative CheW interface [polypeptide binding]; other site 366394009311 STAS domain; Region: STAS_2; pfam13466 366394009312 Response regulator receiver domain; Region: Response_reg; pfam00072 366394009313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394009314 active site 366394009315 phosphorylation site [posttranslational modification] 366394009316 intermolecular recognition site; other site 366394009317 dimerization interface [polypeptide binding]; other site 366394009318 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 366394009319 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 366394009320 putative binding surface; other site 366394009321 active site 366394009322 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 366394009323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394009324 ATP binding site [chemical binding]; other site 366394009325 Mg2+ binding site [ion binding]; other site 366394009326 G-X-G motif; other site 366394009327 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 366394009328 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 366394009329 putative CheA interaction surface; other site 366394009330 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 366394009331 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 366394009332 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 366394009333 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 366394009334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394009335 active site 366394009336 phosphorylation site [posttranslational modification] 366394009337 intermolecular recognition site; other site 366394009338 dimerization interface [polypeptide binding]; other site 366394009339 CheB methylesterase; Region: CheB_methylest; pfam01339 366394009340 Response regulator receiver domain; Region: Response_reg; pfam00072 366394009341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394009342 active site 366394009343 phosphorylation site [posttranslational modification] 366394009344 intermolecular recognition site; other site 366394009345 dimerization interface [polypeptide binding]; other site 366394009346 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13497 366394009347 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 366394009348 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 366394009349 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 366394009350 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394009351 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394009352 dimerization interface [polypeptide binding]; other site 366394009353 DNA binding residues [nucleotide binding] 366394009354 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394009355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394009356 DNA binding residues [nucleotide binding] 366394009357 dimerization interface [polypeptide binding]; other site 366394009358 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 366394009359 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 366394009360 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 366394009361 MgtE intracellular N domain; Region: MgtE_N; smart00924 366394009362 FliG C-terminal domain; Region: FliG_C; pfam01706 366394009363 flagellar motor switch protein FliN; Region: fliN; TIGR02480 366394009364 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 366394009365 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 366394009366 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 366394009367 flagellar motor protein MotA; Validated; Region: PRK09110 366394009368 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 366394009369 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 366394009370 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 366394009371 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 366394009372 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 366394009373 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 366394009374 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 366394009375 Walker A motif; other site 366394009376 ATP binding site [chemical binding]; other site 366394009377 Walker B motif; other site 366394009378 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 366394009379 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 366394009380 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 366394009381 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 366394009382 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 366394009383 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 366394009384 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 366394009385 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 366394009386 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 366394009387 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 366394009388 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 366394009389 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 366394009390 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 366394009391 Uncharacterized conserved protein [Function unknown]; Region: COG3334 366394009392 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 366394009393 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 366394009394 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 366394009395 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 366394009396 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 366394009397 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 366394009398 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 366394009399 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 366394009400 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 366394009401 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 366394009402 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 366394009403 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 366394009404 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 366394009405 flagellin; Reviewed; Region: PRK12687 366394009406 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 366394009407 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 366394009408 flagellar motor protein MotB; Validated; Region: motB; PRK05996 366394009409 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 366394009410 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 366394009411 ligand binding site [chemical binding]; other site 366394009412 chemotaxis protein; Reviewed; Region: PRK12798 366394009413 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 366394009414 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 366394009415 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 366394009416 N-acetyl-D-glucosamine binding site [chemical binding]; other site 366394009417 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 366394009418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394009419 DNA binding site [nucleotide binding] 366394009420 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 366394009421 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 366394009422 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 366394009423 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 366394009424 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 366394009425 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 366394009426 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 366394009427 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 366394009428 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 366394009429 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 366394009430 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 366394009431 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 366394009432 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 366394009433 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 366394009434 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 366394009435 FHIPEP family; Region: FHIPEP; pfam00771 366394009436 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 366394009437 Rod binding protein; Region: Rod-binding; pfam10135 366394009438 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 366394009439 active site 366394009440 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 366394009441 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 366394009442 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 366394009443 homodimer interface [polypeptide binding]; other site 366394009444 NADP binding site [chemical binding]; other site 366394009445 substrate binding site [chemical binding]; other site 366394009446 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394009447 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394009448 DNA binding site [nucleotide binding] 366394009449 domain linker motif; other site 366394009450 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 366394009451 ligand binding site [chemical binding]; other site 366394009452 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394009453 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394009454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394009455 dimer interface [polypeptide binding]; other site 366394009456 conserved gate region; other site 366394009457 putative PBP binding loops; other site 366394009458 ABC-ATPase subunit interface; other site 366394009459 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394009460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394009461 dimer interface [polypeptide binding]; other site 366394009462 conserved gate region; other site 366394009463 putative PBP binding loops; other site 366394009464 ABC-ATPase subunit interface; other site 366394009465 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 366394009466 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 366394009467 active site 366394009468 catalytic site [active] 366394009469 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394009470 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394009471 Walker A/P-loop; other site 366394009472 ATP binding site [chemical binding]; other site 366394009473 Q-loop/lid; other site 366394009474 ABC transporter signature motif; other site 366394009475 Walker B; other site 366394009476 D-loop; other site 366394009477 H-loop/switch region; other site 366394009478 TOBE domain; Region: TOBE_2; pfam08402 366394009479 6-phosphogluconate dehydratase; Region: edd; TIGR01196 366394009480 phosphogluconate dehydratase; Validated; Region: PRK09054 366394009481 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 366394009482 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 366394009483 putative active site [active] 366394009484 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 366394009485 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 366394009486 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 366394009487 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 366394009488 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394009489 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 366394009490 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 366394009491 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 366394009492 Predicted flavoproteins [General function prediction only]; Region: COG2081 366394009493 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 366394009494 dimerization interface [polypeptide binding]; other site 366394009495 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 366394009496 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 366394009497 dimer interface [polypeptide binding]; other site 366394009498 putative CheW interface [polypeptide binding]; other site 366394009499 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394009500 isocitrate lyase; Provisional; Region: PRK15063 366394009501 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 366394009502 tetramer interface [polypeptide binding]; other site 366394009503 active site 366394009504 Mg2+/Mn2+ binding site [ion binding]; other site 366394009505 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394009506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394009507 non-specific DNA binding site [nucleotide binding]; other site 366394009508 salt bridge; other site 366394009509 sequence-specific DNA binding site [nucleotide binding]; other site 366394009510 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 366394009511 Domain of unknown function (DUF955); Region: DUF955; pfam06114 366394009512 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 366394009513 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 366394009514 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394009515 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394009516 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 366394009517 Walker A/P-loop; other site 366394009518 ATP binding site [chemical binding]; other site 366394009519 Q-loop/lid; other site 366394009520 ABC transporter signature motif; other site 366394009521 Walker B; other site 366394009522 D-loop; other site 366394009523 H-loop/switch region; other site 366394009524 TOBE domain; Region: TOBE_2; pfam08402 366394009525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394009526 dimer interface [polypeptide binding]; other site 366394009527 conserved gate region; other site 366394009528 putative PBP binding loops; other site 366394009529 ABC-ATPase subunit interface; other site 366394009530 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394009531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394009532 dimer interface [polypeptide binding]; other site 366394009533 conserved gate region; other site 366394009534 putative PBP binding loops; other site 366394009535 ABC-ATPase subunit interface; other site 366394009536 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 366394009537 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 366394009538 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 366394009539 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 366394009540 acyl-activating enzyme (AAE) consensus motif; other site 366394009541 putative AMP binding site [chemical binding]; other site 366394009542 putative active site [active] 366394009543 putative CoA binding site [chemical binding]; other site 366394009544 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 366394009545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394009546 dimer interface [polypeptide binding]; other site 366394009547 conserved gate region; other site 366394009548 putative PBP binding loops; other site 366394009549 ABC-ATPase subunit interface; other site 366394009550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394009551 dimer interface [polypeptide binding]; other site 366394009552 conserved gate region; other site 366394009553 putative PBP binding loops; other site 366394009554 ABC-ATPase subunit interface; other site 366394009555 PAS domain S-box; Region: sensory_box; TIGR00229 366394009556 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394009557 putative active site [active] 366394009558 heme pocket [chemical binding]; other site 366394009559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394009560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394009561 dimer interface [polypeptide binding]; other site 366394009562 phosphorylation site [posttranslational modification] 366394009563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394009564 ATP binding site [chemical binding]; other site 366394009565 Mg2+ binding site [ion binding]; other site 366394009566 G-X-G motif; other site 366394009567 Phasin protein; Region: Phasin_2; cl11491 366394009568 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394009569 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394009570 DNA binding residues [nucleotide binding] 366394009571 dimerization interface [polypeptide binding]; other site 366394009572 short chain dehydrogenase; Provisional; Region: PRK07063 366394009573 classical (c) SDRs; Region: SDR_c; cd05233 366394009574 NAD(P) binding site [chemical binding]; other site 366394009575 active site 366394009576 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 366394009577 FAD binding domain; Region: FAD_binding_4; pfam01565 366394009578 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 366394009579 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394009580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394009581 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394009582 dimerization interface [polypeptide binding]; other site 366394009583 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 366394009584 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 366394009585 tetrameric interface [polypeptide binding]; other site 366394009586 NAD binding site [chemical binding]; other site 366394009587 catalytic residues [active] 366394009588 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 366394009589 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 366394009590 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 366394009591 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 366394009592 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 366394009593 Rrf2 family protein; Region: rrf2_super; TIGR00738 366394009594 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394009595 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 366394009596 peptide binding site [polypeptide binding]; other site 366394009597 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394009598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394009599 dimer interface [polypeptide binding]; other site 366394009600 conserved gate region; other site 366394009601 putative PBP binding loops; other site 366394009602 ABC-ATPase subunit interface; other site 366394009603 dipeptide transporter; Provisional; Region: PRK10913 366394009604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394009605 dimer interface [polypeptide binding]; other site 366394009606 conserved gate region; other site 366394009607 putative PBP binding loops; other site 366394009608 ABC-ATPase subunit interface; other site 366394009609 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394009610 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 366394009611 Walker A/P-loop; other site 366394009612 ATP binding site [chemical binding]; other site 366394009613 Q-loop/lid; other site 366394009614 ABC transporter signature motif; other site 366394009615 Walker B; other site 366394009616 D-loop; other site 366394009617 H-loop/switch region; other site 366394009618 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394009619 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394009620 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 366394009621 Walker A/P-loop; other site 366394009622 ATP binding site [chemical binding]; other site 366394009623 Q-loop/lid; other site 366394009624 ABC transporter signature motif; other site 366394009625 Walker B; other site 366394009626 D-loop; other site 366394009627 H-loop/switch region; other site 366394009628 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394009629 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 366394009630 homotrimer interaction site [polypeptide binding]; other site 366394009631 putative active site [active] 366394009632 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 366394009633 two-component response regulator; Provisional; Region: PRK09191 366394009634 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 366394009635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394009636 active site 366394009637 phosphorylation site [posttranslational modification] 366394009638 intermolecular recognition site; other site 366394009639 dimerization interface [polypeptide binding]; other site 366394009640 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394009641 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 366394009642 hydroxyglutarate oxidase; Provisional; Region: PRK11728 366394009643 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 366394009644 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 366394009645 putative ligand binding site [chemical binding]; other site 366394009646 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394009647 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394009648 TM-ABC transporter signature motif; other site 366394009649 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 366394009650 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394009651 Walker A/P-loop; other site 366394009652 ATP binding site [chemical binding]; other site 366394009653 Q-loop/lid; other site 366394009654 ABC transporter signature motif; other site 366394009655 Walker B; other site 366394009656 D-loop; other site 366394009657 H-loop/switch region; other site 366394009658 acetylornithine deacetylase; Validated; Region: PRK06915 366394009659 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 366394009660 metal binding site [ion binding]; metal-binding site 366394009661 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 366394009662 MgtC family; Region: MgtC; pfam02308 366394009663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 366394009664 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 366394009665 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 366394009666 Phospholipid methyltransferase; Region: PEMT; pfam04191 366394009667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 366394009668 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 366394009669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 366394009670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394009671 DNA-binding site [nucleotide binding]; DNA binding site 366394009672 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394009673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 366394009674 DNA-binding site [nucleotide binding]; DNA binding site 366394009675 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 366394009676 aconitate hydratase; Provisional; Region: acnA; PRK12881 366394009677 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 366394009678 substrate binding site [chemical binding]; other site 366394009679 ligand binding site [chemical binding]; other site 366394009680 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 366394009681 substrate binding site [chemical binding]; other site 366394009682 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394009683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394009684 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 366394009685 putative effector binding pocket; other site 366394009686 putative dimerization interface [polypeptide binding]; other site 366394009687 SnoaL-like domain; Region: SnoaL_2; pfam12680 366394009688 short chain dehydrogenase; Provisional; Region: PRK06523 366394009689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394009690 NAD(P) binding site [chemical binding]; other site 366394009691 active site 366394009692 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 366394009693 MarR family; Region: MarR; pfam01047 366394009694 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 366394009695 Serine hydrolase; Region: Ser_hydrolase; cl17834 366394009696 choline dehydrogenase; Validated; Region: PRK02106 366394009697 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 366394009698 exopolyphosphatase; Region: exo_poly_only; TIGR03706 366394009699 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 366394009700 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 366394009701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394009702 S-adenosylmethionine binding site [chemical binding]; other site 366394009703 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394009704 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 366394009705 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394009706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394009707 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394009708 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394009709 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394009710 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394009711 putative transporter; Provisional; Region: PRK10504 366394009712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394009713 putative substrate translocation pore; other site 366394009714 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 366394009715 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 366394009716 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 366394009717 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 366394009718 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 366394009719 active site 366394009720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5331 366394009721 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 366394009722 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 366394009723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394009724 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 366394009725 dimerization interface [polypeptide binding]; other site 366394009726 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 366394009727 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 366394009728 tetramer interface [polypeptide binding]; other site 366394009729 heme binding pocket [chemical binding]; other site 366394009730 NADPH binding site [chemical binding]; other site 366394009731 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394009732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394009733 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394009734 dimerization interface [polypeptide binding]; other site 366394009735 Uncharacterized conserved protein [Function unknown]; Region: COG5403 366394009736 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 366394009737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 366394009738 RNA methyltransferase, RsmE family; Region: TIGR00046 366394009739 Phosphate transporter family; Region: PHO4; pfam01384 366394009740 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 366394009741 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 366394009742 nudix motif; other site 366394009743 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394009744 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394009745 DNA-binding site [nucleotide binding]; DNA binding site 366394009746 FCD domain; Region: FCD; pfam07729 366394009747 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4949 366394009748 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394009749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394009750 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 366394009751 putative effector binding pocket; other site 366394009752 dimerization interface [polypeptide binding]; other site 366394009753 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 366394009754 FAD binding domain; Region: FAD_binding_4; pfam01565 366394009755 FAD binding domain; Region: FAD_binding_4; pfam01565 366394009756 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 366394009757 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 366394009758 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 366394009759 Cysteine-rich domain; Region: CCG; pfam02754 366394009760 Cysteine-rich domain; Region: CCG; pfam02754 366394009761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 366394009762 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394009763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 366394009764 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394009765 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 366394009766 Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953 366394009767 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 366394009768 Na binding site [ion binding]; other site 366394009769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 366394009770 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 366394009771 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 366394009772 dimer interface [polypeptide binding]; other site 366394009773 motif 1; other site 366394009774 motif 2; other site 366394009775 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 366394009776 active site 366394009777 motif 3; other site 366394009778 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 366394009779 anticodon binding site; other site 366394009780 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 366394009781 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 366394009782 motif 1; other site 366394009783 dimer interface [polypeptide binding]; other site 366394009784 active site 366394009785 motif 2; other site 366394009786 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 366394009787 motif 3; other site 366394009788 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 366394009789 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 366394009790 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 366394009791 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 366394009792 C-terminal domain interface [polypeptide binding]; other site 366394009793 GSH binding site (G-site) [chemical binding]; other site 366394009794 dimer interface [polypeptide binding]; other site 366394009795 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 366394009796 N-terminal domain interface [polypeptide binding]; other site 366394009797 dimer interface [polypeptide binding]; other site 366394009798 substrate binding pocket (H-site) [chemical binding]; other site 366394009799 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 366394009800 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 366394009801 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394009802 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 366394009803 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 366394009804 ring oligomerisation interface [polypeptide binding]; other site 366394009805 ATP/Mg binding site [chemical binding]; other site 366394009806 stacking interactions; other site 366394009807 hinge regions; other site 366394009808 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 366394009809 oligomerisation interface [polypeptide binding]; other site 366394009810 mobile loop; other site 366394009811 roof hairpin; other site 366394009812 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 366394009813 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 366394009814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394009815 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 366394009816 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 366394009817 active site 366394009818 Riboflavin kinase; Region: Flavokinase; smart00904 366394009819 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 366394009820 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 366394009821 active site 366394009822 HIGH motif; other site 366394009823 nucleotide binding site [chemical binding]; other site 366394009824 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 366394009825 active site 366394009826 KMSKS motif; other site 366394009827 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 366394009828 tRNA binding surface [nucleotide binding]; other site 366394009829 anticodon binding site; other site 366394009830 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 366394009831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394009832 Coenzyme A binding pocket [chemical binding]; other site 366394009833 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 366394009834 nucleoside/Zn binding site; other site 366394009835 dimer interface [polypeptide binding]; other site 366394009836 catalytic motif [active] 366394009837 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 366394009838 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 366394009839 RNA binding surface [nucleotide binding]; other site 366394009840 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 366394009841 active site 366394009842 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 366394009843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394009844 S-adenosylmethionine binding site [chemical binding]; other site 366394009845 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 366394009846 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 366394009847 nucleophile elbow; other site 366394009848 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 366394009849 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 366394009850 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 366394009851 TrkA-N domain; Region: TrkA_N; pfam02254 366394009852 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 366394009853 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 366394009854 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 366394009855 active site 366394009856 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 366394009857 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 366394009858 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 366394009859 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 366394009860 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 366394009861 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394009862 motif II; other site 366394009863 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 366394009864 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 366394009865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 366394009866 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 366394009867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394009868 ATP binding site [chemical binding]; other site 366394009869 Mg2+ binding site [ion binding]; other site 366394009870 G-X-G motif; other site 366394009871 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 366394009872 ATP binding site [chemical binding]; other site 366394009873 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 366394009874 PAS fold; Region: PAS_4; pfam08448 366394009875 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394009876 putative active site [active] 366394009877 heme pocket [chemical binding]; other site 366394009878 Response regulator receiver domain; Region: Response_reg; pfam00072 366394009879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394009880 active site 366394009881 phosphorylation site [posttranslational modification] 366394009882 intermolecular recognition site; other site 366394009883 dimerization interface [polypeptide binding]; other site 366394009884 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394009885 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394009886 metal binding site [ion binding]; metal-binding site 366394009887 active site 366394009888 I-site; other site 366394009889 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 366394009890 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 366394009891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394009892 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 366394009893 dimerization interface [polypeptide binding]; other site 366394009894 substrate binding pocket [chemical binding]; other site 366394009895 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 366394009896 PRC-barrel domain; Region: PRC; pfam05239 366394009897 dihydroxy-acid dehydratase; Validated; Region: PRK06131 366394009898 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 366394009899 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 366394009900 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 366394009901 active site 366394009902 intersubunit interface [polypeptide binding]; other site 366394009903 catalytic residue [active] 366394009904 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 366394009905 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 366394009906 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 366394009907 classical (c) SDRs; Region: SDR_c; cd05233 366394009908 NAD(P) binding site [chemical binding]; other site 366394009909 active site 366394009910 Transcriptional regulator [Transcription]; Region: IclR; COG1414 366394009911 Bacterial transcriptional regulator; Region: IclR; pfam01614 366394009912 Autoinducer binding domain; Region: Autoind_bind; pfam03472 366394009913 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394009914 DNA binding residues [nucleotide binding] 366394009915 dimerization interface [polypeptide binding]; other site 366394009916 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 366394009917 Autoinducer binding domain; Region: Autoind_bind; pfam03472 366394009918 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394009919 DNA binding residues [nucleotide binding] 366394009920 dimerization interface [polypeptide binding]; other site 366394009921 Domain of unknown function DUF59; Region: DUF59; pfam01883 366394009922 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 366394009923 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 366394009924 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 366394009925 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 366394009926 Cl binding site [ion binding]; other site 366394009927 oligomer interface [polypeptide binding]; other site 366394009928 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 366394009929 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 366394009930 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 366394009931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 366394009932 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 366394009933 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 366394009934 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 366394009935 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 366394009936 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 366394009937 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 366394009938 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 366394009939 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 366394009940 RNA/DNA hybrid binding site [nucleotide binding]; other site 366394009941 active site 366394009942 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 366394009943 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 366394009944 FeS/SAM binding site; other site 366394009945 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 366394009946 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 366394009947 active site 366394009948 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 366394009949 MPT binding site; other site 366394009950 trimer interface [polypeptide binding]; other site 366394009951 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 366394009952 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 366394009953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394009954 binding surface 366394009955 TPR motif; other site 366394009956 TPR repeat; Region: TPR_11; pfam13414 366394009957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394009958 binding surface 366394009959 TPR motif; other site 366394009960 TPR repeat; Region: TPR_11; pfam13414 366394009961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394009962 binding surface 366394009963 TPR motif; other site 366394009964 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 366394009965 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 366394009966 substrate binding pocket [chemical binding]; other site 366394009967 chain length determination region; other site 366394009968 substrate-Mg2+ binding site; other site 366394009969 catalytic residues [active] 366394009970 aspartate-rich region 1; other site 366394009971 active site lid residues [active] 366394009972 aspartate-rich region 2; other site 366394009973 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 366394009974 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 366394009975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394009976 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 366394009977 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 366394009978 tandem repeat interface [polypeptide binding]; other site 366394009979 oligomer interface [polypeptide binding]; other site 366394009980 active site residues [active] 366394009981 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 366394009982 dimer interface [polypeptide binding]; other site 366394009983 motif 1; other site 366394009984 active site 366394009985 motif 2; other site 366394009986 motif 3; other site 366394009987 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 366394009988 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 366394009989 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 366394009990 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 366394009991 Uncharacterized conserved protein [Function unknown]; Region: COG1683 366394009992 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 366394009993 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 366394009994 oligomeric interface; other site 366394009995 putative active site [active] 366394009996 homodimer interface [polypeptide binding]; other site 366394009997 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 366394009998 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 366394009999 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 366394010000 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 366394010001 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394010002 metal binding site [ion binding]; metal-binding site 366394010003 active site 366394010004 I-site; other site 366394010005 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 366394010006 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 366394010007 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394010008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394010009 Major Facilitator Superfamily; Region: MFS_1; pfam07690 366394010010 putative substrate translocation pore; other site 366394010011 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 366394010012 Helix-turn-helix domain; Region: HTH_18; pfam12833 366394010013 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 366394010014 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 366394010015 UbiA prenyltransferase family; Region: UbiA; pfam01040 366394010016 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 366394010017 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 366394010018 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 366394010019 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 366394010020 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 366394010021 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 366394010022 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 366394010023 FAD binding domain; Region: FAD_binding_4; pfam01565 366394010024 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 366394010025 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 366394010026 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 366394010027 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 366394010028 [2Fe-2S] cluster binding site [ion binding]; other site 366394010029 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 366394010030 putative alpha subunit interface [polypeptide binding]; other site 366394010031 putative active site [active] 366394010032 putative substrate binding site [chemical binding]; other site 366394010033 Fe binding site [ion binding]; other site 366394010034 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 366394010035 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 366394010036 FAD binding pocket [chemical binding]; other site 366394010037 FAD binding motif [chemical binding]; other site 366394010038 phosphate binding motif [ion binding]; other site 366394010039 beta-alpha-beta structure motif; other site 366394010040 NAD binding pocket [chemical binding]; other site 366394010041 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394010042 catalytic loop [active] 366394010043 iron binding site [ion binding]; other site 366394010044 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 366394010045 active site 366394010046 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 366394010047 BA14K-like protein; Region: BA14K; pfam07886 366394010048 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 366394010049 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 366394010050 active site 366394010051 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 366394010052 enoyl-CoA hydratase; Provisional; Region: PRK06688 366394010053 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 366394010054 substrate binding site [chemical binding]; other site 366394010055 oxyanion hole (OAH) forming residues; other site 366394010056 trimer interface [polypeptide binding]; other site 366394010057 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 366394010058 Cache domain; Region: Cache_1; pfam02743 366394010059 HAMP domain; Region: HAMP; pfam00672 366394010060 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 366394010061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 366394010062 dimer interface [polypeptide binding]; other site 366394010063 putative CheW interface [polypeptide binding]; other site 366394010064 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 366394010065 TRAM domain; Region: TRAM; cl01282 366394010066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394010067 S-adenosylmethionine binding site [chemical binding]; other site 366394010068 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 366394010069 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 366394010070 RNA binding surface [nucleotide binding]; other site 366394010071 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 366394010072 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 366394010073 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 366394010074 TPP-binding site; other site 366394010075 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 366394010076 PYR/PP interface [polypeptide binding]; other site 366394010077 dimer interface [polypeptide binding]; other site 366394010078 TPP binding site [chemical binding]; other site 366394010079 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 366394010080 Pirin-related protein [General function prediction only]; Region: COG1741 366394010081 Pirin; Region: Pirin; pfam02678 366394010082 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 366394010083 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 366394010084 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 366394010085 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 366394010086 putative active site [active] 366394010087 Zn binding site [ion binding]; other site 366394010088 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 366394010089 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 366394010090 NADP binding site [chemical binding]; other site 366394010091 dimer interface [polypeptide binding]; other site 366394010092 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 366394010093 active site 366394010094 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 366394010095 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 366394010096 dimer interface [polypeptide binding]; other site 366394010097 active site 366394010098 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 366394010099 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 366394010100 acyl-activating enzyme (AAE) consensus motif; other site 366394010101 AMP binding site [chemical binding]; other site 366394010102 active site 366394010103 CoA binding site [chemical binding]; other site 366394010104 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 366394010105 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 366394010106 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 366394010107 Walker A/P-loop; other site 366394010108 ATP binding site [chemical binding]; other site 366394010109 Q-loop/lid; other site 366394010110 ABC transporter signature motif; other site 366394010111 Walker B; other site 366394010112 D-loop; other site 366394010113 H-loop/switch region; other site 366394010114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 366394010115 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 366394010116 protease TldD; Provisional; Region: tldD; PRK10735 366394010117 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 366394010118 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 366394010119 Sporulation related domain; Region: SPOR; cl10051 366394010120 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 366394010121 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 366394010122 putative active site [active] 366394010123 putative metal binding site [ion binding]; other site 366394010124 Predicted membrane protein [Function unknown]; Region: COG4325 366394010125 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 366394010126 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 366394010127 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 366394010128 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 366394010129 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 366394010130 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 366394010131 HSP70 interaction site [polypeptide binding]; other site 366394010132 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 366394010133 substrate binding site [polypeptide binding]; other site 366394010134 dimer interface [polypeptide binding]; other site 366394010135 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 366394010136 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 366394010137 NAD binding site [chemical binding]; other site 366394010138 homotetramer interface [polypeptide binding]; other site 366394010139 homodimer interface [polypeptide binding]; other site 366394010140 substrate binding site [chemical binding]; other site 366394010141 active site 366394010142 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 366394010143 catalytic core [active] 366394010144 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 366394010145 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 366394010146 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 366394010147 Tetramer interface [polypeptide binding]; other site 366394010148 active site 366394010149 FMN-binding site [chemical binding]; other site 366394010150 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 366394010151 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 366394010152 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 366394010153 dimerization interface [polypeptide binding]; other site 366394010154 active site 366394010155 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 366394010156 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00051 366394010157 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 366394010158 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 366394010159 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 366394010160 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 366394010161 Subunit I/III interface [polypeptide binding]; other site 366394010162 D-pathway; other site 366394010163 Subunit I/VIIc interface [polypeptide binding]; other site 366394010164 Subunit I/IV interface [polypeptide binding]; other site 366394010165 Subunit I/II interface [polypeptide binding]; other site 366394010166 Low-spin heme (heme a) binding site [chemical binding]; other site 366394010167 Subunit I/VIIa interface [polypeptide binding]; other site 366394010168 Subunit I/VIa interface [polypeptide binding]; other site 366394010169 Dimer interface; other site 366394010170 Putative water exit pathway; other site 366394010171 Binuclear center (heme a3/CuB) [ion binding]; other site 366394010172 K-pathway; other site 366394010173 Subunit I/Vb interface [polypeptide binding]; other site 366394010174 Putative proton exit pathway; other site 366394010175 Subunit I/VIb interface; other site 366394010176 Subunit I/VIc interface [polypeptide binding]; other site 366394010177 Electron transfer pathway; other site 366394010178 Subunit I/VIIIb interface [polypeptide binding]; other site 366394010179 Subunit I/VIIb interface [polypeptide binding]; other site 366394010180 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 366394010181 UbiA prenyltransferase family; Region: UbiA; pfam01040 366394010182 Coiled-coil domain-containing protein 56; Region: Coiled-coil_56; pfam09813 366394010183 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 366394010184 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 366394010185 Subunit III/VIIa interface [polypeptide binding]; other site 366394010186 Phospholipid binding site [chemical binding]; other site 366394010187 Subunit I/III interface [polypeptide binding]; other site 366394010188 Subunit III/VIb interface [polypeptide binding]; other site 366394010189 Subunit III/VIa interface; other site 366394010190 Subunit III/Vb interface [polypeptide binding]; other site 366394010191 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394010192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 366394010193 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 366394010194 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 366394010195 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 366394010196 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 366394010197 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 366394010198 putative active site [active] 366394010199 putative substrate binding site [chemical binding]; other site 366394010200 ATP binding site [chemical binding]; other site 366394010201 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 366394010202 RNA/DNA hybrid binding site [nucleotide binding]; other site 366394010203 active site 366394010204 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 366394010205 catalytic triad [active] 366394010206 dimer interface [polypeptide binding]; other site 366394010207 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 366394010208 hypothetical protein; Validated; Region: PRK00228 366394010209 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 366394010210 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 366394010211 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394010212 PAS fold; Region: PAS_3; pfam08447 366394010213 putative active site [active] 366394010214 heme pocket [chemical binding]; other site 366394010215 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394010216 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394010217 metal binding site [ion binding]; metal-binding site 366394010218 active site 366394010219 I-site; other site 366394010220 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 366394010221 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 366394010222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 366394010223 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 366394010224 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 366394010225 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 366394010226 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 366394010227 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 366394010228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394010229 catalytic residue [active] 366394010230 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 366394010231 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 366394010232 dimerization interface [polypeptide binding]; other site 366394010233 ligand binding site [chemical binding]; other site 366394010234 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 366394010235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394010236 motif II; other site 366394010237 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394010238 dimerization interface [polypeptide binding]; other site 366394010239 putative DNA binding site [nucleotide binding]; other site 366394010240 putative Zn2+ binding site [ion binding]; other site 366394010241 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 366394010242 DNA methylase; Region: N6_N4_Mtase; pfam01555 366394010243 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 366394010244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394010245 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 366394010246 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 366394010247 minor groove reading motif; other site 366394010248 helix-hairpin-helix signature motif; other site 366394010249 substrate binding pocket [chemical binding]; other site 366394010250 active site 366394010251 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 366394010252 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 366394010253 DNA binding and oxoG recognition site [nucleotide binding] 366394010254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 366394010255 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 366394010256 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 366394010257 catalytic residues [active] 366394010258 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 366394010259 putative active site [active] 366394010260 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 366394010261 AAA domain; Region: AAA_23; pfam13476 366394010262 Walker A/P-loop; other site 366394010263 ATP binding site [chemical binding]; other site 366394010264 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 366394010265 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 366394010266 ABC transporter signature motif; other site 366394010267 Walker B; other site 366394010268 D-loop; other site 366394010269 H-loop/switch region; other site 366394010270 pyruvate phosphate dikinase; Provisional; Region: PRK09279 366394010271 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 366394010272 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 366394010273 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 366394010274 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 366394010275 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 366394010276 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 366394010277 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 366394010278 Mechanosensitive ion channel; Region: MS_channel; pfam00924 366394010279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394010280 non-specific DNA binding site [nucleotide binding]; other site 366394010281 salt bridge; other site 366394010282 sequence-specific DNA binding site [nucleotide binding]; other site 366394010283 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 366394010284 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 366394010285 CysD dimerization site [polypeptide binding]; other site 366394010286 G1 box; other site 366394010287 putative GEF interaction site [polypeptide binding]; other site 366394010288 GTP/Mg2+ binding site [chemical binding]; other site 366394010289 Switch I region; other site 366394010290 G2 box; other site 366394010291 G3 box; other site 366394010292 Switch II region; other site 366394010293 G4 box; other site 366394010294 G5 box; other site 366394010295 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 366394010296 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 366394010297 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 366394010298 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 366394010299 Active Sites [active] 366394010300 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 366394010301 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 366394010302 Active Sites [active] 366394010303 choline dehydrogenase; Validated; Region: PRK02106 366394010304 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 366394010305 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 366394010306 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 366394010307 NAD(P) binding site [chemical binding]; other site 366394010308 catalytic residues [active] 366394010309 Sulfatase; Region: Sulfatase; cl17466 366394010310 choline-sulfatase; Region: chol_sulfatase; TIGR03417 366394010311 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 366394010312 transcriptional regulator BetI; Validated; Region: PRK00767 366394010313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394010314 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 366394010315 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 366394010316 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 366394010317 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 366394010318 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394010319 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394010320 metal binding site [ion binding]; metal-binding site 366394010321 active site 366394010322 I-site; other site 366394010323 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 366394010324 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 366394010325 NAD(P) binding site [chemical binding]; other site 366394010326 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 366394010327 L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448 366394010328 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394010329 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 366394010330 C-terminal domain interface [polypeptide binding]; other site 366394010331 GSH binding site (G-site) [chemical binding]; other site 366394010332 dimer interface [polypeptide binding]; other site 366394010333 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 366394010334 dimer interface [polypeptide binding]; other site 366394010335 N-terminal domain interface [polypeptide binding]; other site 366394010336 substrate binding pocket (H-site) [chemical binding]; other site 366394010337 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 366394010338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394010339 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 366394010340 dimerization interface [polypeptide binding]; other site 366394010341 substrate binding pocket [chemical binding]; other site 366394010342 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394010343 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 366394010344 putative C-terminal domain interface [polypeptide binding]; other site 366394010345 putative GSH binding site (G-site) [chemical binding]; other site 366394010346 putative dimer interface [polypeptide binding]; other site 366394010347 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 366394010348 dimer interface [polypeptide binding]; other site 366394010349 N-terminal domain interface [polypeptide binding]; other site 366394010350 putative substrate binding pocket (H-site) [chemical binding]; other site 366394010351 PAS fold; Region: PAS_4; pfam08448 366394010352 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 366394010353 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 366394010354 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394010355 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394010356 metal binding site [ion binding]; metal-binding site 366394010357 active site 366394010358 I-site; other site 366394010359 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 366394010360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 366394010361 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394010362 Transcriptional regulators [Transcription]; Region: MarR; COG1846 366394010363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394010364 putative DNA binding site [nucleotide binding]; other site 366394010365 putative Zn2+ binding site [ion binding]; other site 366394010366 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 366394010367 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 366394010368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 366394010369 Walker A motif; other site 366394010370 ATP binding site [chemical binding]; other site 366394010371 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394010372 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394010373 active site 366394010374 catalytic tetrad [active] 366394010375 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 366394010376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394010377 S-adenosylmethionine binding site [chemical binding]; other site 366394010378 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 366394010379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394010380 motif II; other site 366394010381 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 366394010382 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 366394010383 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 366394010384 putative NAD(P) binding site [chemical binding]; other site 366394010385 catalytic Zn binding site [ion binding]; other site 366394010386 structural Zn binding site [ion binding]; other site 366394010387 aminotransferase; Provisional; Region: PRK13356 366394010388 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 366394010389 homodimer interface [polypeptide binding]; other site 366394010390 substrate-cofactor binding pocket; other site 366394010391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394010392 catalytic residue [active] 366394010393 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 366394010394 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394010395 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 366394010396 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 366394010397 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 366394010398 Predicted transcriptional regulator [Transcription]; Region: COG2378 366394010399 HTH domain; Region: HTH_11; pfam08279 366394010400 WYL domain; Region: WYL; pfam13280 366394010401 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 366394010402 Cytochrome c556 [Energy production and conversion]; Region: COG3909 366394010403 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 366394010404 Cytochrome c; Region: Cytochrom_C; pfam00034 366394010405 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 366394010406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394010407 Coenzyme A binding pocket [chemical binding]; other site 366394010408 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 366394010409 DNA binding residues [nucleotide binding] 366394010410 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 366394010411 dimer interface [polypeptide binding]; other site 366394010412 putative metal binding site [ion binding]; other site 366394010413 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 366394010414 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 366394010415 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 366394010416 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 366394010417 Trp docking motif [polypeptide binding]; other site 366394010418 putative active site [active] 366394010419 hypothetical protein; Validated; Region: PRK00029 366394010420 Uncharacterized conserved protein [Function unknown]; Region: COG0397 366394010421 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 366394010422 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 366394010423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 366394010424 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 366394010425 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 366394010426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394010427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394010428 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 366394010429 putative effector binding pocket; other site 366394010430 dimerization interface [polypeptide binding]; other site 366394010431 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 366394010432 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 366394010433 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 366394010434 putative metal binding site [ion binding]; other site 366394010435 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 366394010436 active site 366394010437 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 366394010438 Ligand Binding Site [chemical binding]; other site 366394010439 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 366394010440 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 366394010441 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 366394010442 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 366394010443 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 366394010444 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 366394010445 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 366394010446 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 366394010447 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658 366394010448 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 366394010449 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 366394010450 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 366394010451 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 366394010452 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 366394010453 Predicted transcriptional regulator [Transcription]; Region: COG4957 366394010454 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 366394010455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394010456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394010457 dimer interface [polypeptide binding]; other site 366394010458 phosphorylation site [posttranslational modification] 366394010459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394010460 ATP binding site [chemical binding]; other site 366394010461 Mg2+ binding site [ion binding]; other site 366394010462 G-X-G motif; other site 366394010463 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 366394010464 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394010465 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394010466 Uncharacterized conserved protein [Function unknown]; Region: COG5447 366394010467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 366394010468 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 366394010469 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 366394010470 Bacterial SH3 domain; Region: SH3_3; pfam08239 366394010471 Predicted integral membrane protein [Function unknown]; Region: COG5436 366394010472 Uncharacterized conserved protein [Function unknown]; Region: COG5402 366394010473 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 366394010474 Transglycosylase; Region: Transgly; pfam00912 366394010475 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 366394010476 hypothetical protein; Provisional; Region: PRK05170 366394010477 Protein of unknown function (DUF419); Region: DUF419; pfam04237 366394010478 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 366394010479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394010480 active site 366394010481 phosphorylation site [posttranslational modification] 366394010482 intermolecular recognition site; other site 366394010483 dimerization interface [polypeptide binding]; other site 366394010484 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394010485 DNA binding site [nucleotide binding] 366394010486 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394010487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394010488 ATP binding site [chemical binding]; other site 366394010489 Mg2+ binding site [ion binding]; other site 366394010490 G-X-G motif; other site 366394010491 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 366394010492 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 366394010493 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 366394010494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394010495 binding surface 366394010496 TPR motif; other site 366394010497 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 366394010498 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 366394010499 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 366394010500 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 366394010501 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 366394010502 protein binding site [polypeptide binding]; other site 366394010503 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 366394010504 protein binding site [polypeptide binding]; other site 366394010505 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 366394010506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394010507 active site 366394010508 phosphorylation site [posttranslational modification] 366394010509 intermolecular recognition site; other site 366394010510 dimerization interface [polypeptide binding]; other site 366394010511 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394010512 DNA binding site [nucleotide binding] 366394010513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394010514 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 366394010515 dimerization interface [polypeptide binding]; other site 366394010516 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394010517 dimer interface [polypeptide binding]; other site 366394010518 phosphorylation site [posttranslational modification] 366394010519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394010520 ATP binding site [chemical binding]; other site 366394010521 Mg2+ binding site [ion binding]; other site 366394010522 G-X-G motif; other site 366394010523 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 366394010524 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 366394010525 metal binding triad; other site 366394010526 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 366394010527 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 366394010528 metal binding triad; other site 366394010529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394010530 PAS fold; Region: PAS_3; pfam08447 366394010531 putative active site [active] 366394010532 heme pocket [chemical binding]; other site 366394010533 PAS fold; Region: PAS_7; pfam12860 366394010534 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394010535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394010536 dimer interface [polypeptide binding]; other site 366394010537 phosphorylation site [posttranslational modification] 366394010538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394010539 ATP binding site [chemical binding]; other site 366394010540 Mg2+ binding site [ion binding]; other site 366394010541 G-X-G motif; other site 366394010542 aminopeptidase N; Provisional; Region: pepN; PRK14015 366394010543 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 366394010544 active site 366394010545 Zn binding site [ion binding]; other site 366394010546 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 366394010547 EamA-like transporter family; Region: EamA; pfam00892 366394010548 EamA-like transporter family; Region: EamA; pfam00892 366394010549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394010550 Major Facilitator Superfamily; Region: MFS_1; pfam07690 366394010551 putative substrate translocation pore; other site 366394010552 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 366394010553 Fe-S cluster binding site [ion binding]; other site 366394010554 active site 366394010555 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 366394010556 putative chaperone; Provisional; Region: PRK11678 366394010557 nucleotide binding site [chemical binding]; other site 366394010558 putative NEF/HSP70 interaction site [polypeptide binding]; other site 366394010559 SBD interface [polypeptide binding]; other site 366394010560 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 366394010561 hydroxyglutarate oxidase; Provisional; Region: PRK11728 366394010562 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 366394010563 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 366394010564 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 366394010565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394010566 dimer interface [polypeptide binding]; other site 366394010567 conserved gate region; other site 366394010568 putative PBP binding loops; other site 366394010569 ABC-ATPase subunit interface; other site 366394010570 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 366394010571 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 366394010572 putative NAD(P) binding site [chemical binding]; other site 366394010573 dimer interface [polypeptide binding]; other site 366394010574 Predicted transcriptional regulators [Transcription]; Region: COG1733 366394010575 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 366394010576 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 366394010577 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 366394010578 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 366394010579 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 366394010580 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 366394010581 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 366394010582 Ligand binding site; other site 366394010583 Putative Catalytic site; other site 366394010584 DXD motif; other site 366394010585 AMP nucleosidase; Provisional; Region: PRK08292 366394010586 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 366394010587 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 366394010588 Uncharacterized conserved protein [Function unknown]; Region: COG1742 366394010589 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 366394010590 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 366394010591 C-terminal domain interface [polypeptide binding]; other site 366394010592 GSH binding site (G-site) [chemical binding]; other site 366394010593 dimer interface [polypeptide binding]; other site 366394010594 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 366394010595 N-terminal domain interface [polypeptide binding]; other site 366394010596 putative dimer interface [polypeptide binding]; other site 366394010597 active site 366394010598 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 366394010599 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 366394010600 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 366394010601 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394010602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394010603 homodimer interface [polypeptide binding]; other site 366394010604 catalytic residue [active] 366394010605 Porin subfamily; Region: Porin_2; pfam02530 366394010606 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 366394010607 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 366394010608 active site 366394010609 DNA binding site [nucleotide binding] 366394010610 Int/Topo IB signature motif; other site 366394010611 Porin subfamily; Region: Porin_2; pfam02530 366394010612 BA14K-like protein; Region: BA14K; pfam07886 366394010613 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 366394010614 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 366394010615 N-acetyl-D-glucosamine binding site [chemical binding]; other site 366394010616 catalytic residue [active] 366394010617 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 366394010618 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 366394010619 dimer interface [polypeptide binding]; other site 366394010620 active site 366394010621 catalytic residue [active] 366394010622 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 366394010623 SmpB-tmRNA interface; other site 366394010624 Uncharacterized conserved protein [Function unknown]; Region: COG1432 366394010625 LabA_like proteins; Region: LabA; cd10911 366394010626 putative metal binding site [ion binding]; other site 366394010627 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 366394010628 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 366394010629 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 366394010630 Zn2+ binding site [ion binding]; other site 366394010631 Mg2+ binding site [ion binding]; other site 366394010632 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 366394010633 synthetase active site [active] 366394010634 NTP binding site [chemical binding]; other site 366394010635 metal binding site [ion binding]; metal-binding site 366394010636 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 366394010637 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 366394010638 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 366394010639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 366394010640 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 366394010641 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 366394010642 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 366394010643 Catalytic site [active] 366394010644 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 366394010645 ribonuclease III; Reviewed; Region: PRK12371 366394010646 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 366394010647 dimerization interface [polypeptide binding]; other site 366394010648 active site 366394010649 metal binding site [ion binding]; metal-binding site 366394010650 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 366394010651 dsRNA binding site [nucleotide binding]; other site 366394010652 GTPase Era; Reviewed; Region: era; PRK00089 366394010653 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 366394010654 G1 box; other site 366394010655 GTP/Mg2+ binding site [chemical binding]; other site 366394010656 Switch I region; other site 366394010657 G2 box; other site 366394010658 Switch II region; other site 366394010659 G3 box; other site 366394010660 G4 box; other site 366394010661 G5 box; other site 366394010662 KH domain; Region: KH_2; pfam07650 366394010663 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 366394010664 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 366394010665 putative active site [active] 366394010666 catalytic site [active] 366394010667 putative metal binding site [ion binding]; other site 366394010668 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 366394010669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394010670 S-adenosylmethionine binding site [chemical binding]; other site 366394010671 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 366394010672 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 366394010673 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 366394010674 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 366394010675 RNA binding site [nucleotide binding]; other site 366394010676 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 366394010677 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 366394010678 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 366394010679 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 366394010680 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394010681 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 366394010682 putative NAD(P) binding site [chemical binding]; other site 366394010683 active site 366394010684 putative substrate binding site [chemical binding]; other site 366394010685 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394010686 dimerization interface [polypeptide binding]; other site 366394010687 putative DNA binding site [nucleotide binding]; other site 366394010688 putative Zn2+ binding site [ion binding]; other site 366394010689 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 366394010690 hydrophobic ligand binding site; other site 366394010691 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 366394010692 active site 366394010693 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 366394010694 Recombination protein O N terminal; Region: RecO_N; pfam11967 366394010695 Recombination protein O C terminal; Region: RecO_C; pfam02565 366394010696 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 366394010697 Predicted membrane protein [Function unknown]; Region: COG5373 366394010698 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 366394010699 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 366394010700 Zn2+ binding site [ion binding]; other site 366394010701 Mg2+ binding site [ion binding]; other site 366394010702 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 366394010703 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 366394010704 MOSC domain; Region: MOSC; pfam03473 366394010705 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 366394010706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394010707 putative substrate translocation pore; other site 366394010708 quinolinate synthetase; Provisional; Region: PRK09375 366394010709 L-aspartate oxidase; Provisional; Region: PRK07512 366394010710 L-aspartate oxidase; Provisional; Region: PRK06175 366394010711 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 366394010712 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 366394010713 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 366394010714 dimerization interface [polypeptide binding]; other site 366394010715 active site 366394010716 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 366394010717 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 366394010718 E-class dimer interface [polypeptide binding]; other site 366394010719 P-class dimer interface [polypeptide binding]; other site 366394010720 active site 366394010721 Cu2+ binding site [ion binding]; other site 366394010722 Zn2+ binding site [ion binding]; other site 366394010723 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 366394010724 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 366394010725 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 366394010726 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 366394010727 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 366394010728 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 366394010729 Protein of unknown function (DUF2385); Region: DUF2385; cl11490 366394010730 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 366394010731 nudix motif; other site 366394010732 Uncharacterized conserved protein [Function unknown]; Region: COG2135 366394010733 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 366394010734 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 366394010735 active site 366394010736 HIGH motif; other site 366394010737 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 366394010738 KMSKS motif; other site 366394010739 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 366394010740 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394010741 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394010742 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394010743 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 366394010744 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 366394010745 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 366394010746 active site 366394010747 catalytic residues [active] 366394010748 metal binding site [ion binding]; metal-binding site 366394010749 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 366394010750 Predicted permeases [General function prediction only]; Region: RarD; COG2962 366394010751 EamA-like transporter family; Region: EamA; cl17759 366394010752 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 366394010753 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 366394010754 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 366394010755 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 366394010756 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 366394010757 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 366394010758 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 366394010759 Walker A/P-loop; other site 366394010760 ATP binding site [chemical binding]; other site 366394010761 Q-loop/lid; other site 366394010762 ABC transporter signature motif; other site 366394010763 Walker B; other site 366394010764 D-loop; other site 366394010765 H-loop/switch region; other site 366394010766 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 366394010767 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 366394010768 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 366394010769 Transposase domain (DUF772); Region: DUF772; pfam05598 366394010770 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 366394010771 classical (c) SDRs; Region: SDR_c; cd05233 366394010772 NAD(P) binding site [chemical binding]; other site 366394010773 active site 366394010774 amidophosphoribosyltransferase; Provisional; Region: PRK09123 366394010775 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 366394010776 active site 366394010777 tetramer interface [polypeptide binding]; other site 366394010778 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 366394010779 active site 366394010780 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 366394010781 Colicin V production protein; Region: Colicin_V; pfam02674 366394010782 DNA repair protein RadA; Provisional; Region: PRK11823 366394010783 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 366394010784 Walker A motif/ATP binding site; other site 366394010785 ATP binding site [chemical binding]; other site 366394010786 Walker B motif; other site 366394010787 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 366394010788 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 366394010789 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 366394010790 active site 366394010791 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 366394010792 dimer interface [polypeptide binding]; other site 366394010793 substrate binding site [chemical binding]; other site 366394010794 catalytic residues [active] 366394010795 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 366394010796 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 366394010797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394010798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394010799 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 366394010800 Predicted membrane protein [Function unknown]; Region: COG4541 366394010801 replicative DNA helicase; Provisional; Region: PRK09165 366394010802 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 366394010803 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 366394010804 Walker A motif; other site 366394010805 ATP binding site [chemical binding]; other site 366394010806 Walker B motif; other site 366394010807 DNA binding loops [nucleotide binding] 366394010808 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 366394010809 MarR family; Region: MarR_2; pfam12802 366394010810 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 366394010811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394010812 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 366394010813 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 366394010814 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394010815 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 366394010816 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 366394010817 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 366394010818 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 366394010819 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 366394010820 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 366394010821 dimerization interface [polypeptide binding]; other site 366394010822 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394010823 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394010824 active site 366394010825 catalytic tetrad [active] 366394010826 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 366394010827 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 366394010828 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 366394010829 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 366394010830 NAD(P) binding site [chemical binding]; other site 366394010831 homotetramer interface [polypeptide binding]; other site 366394010832 homodimer interface [polypeptide binding]; other site 366394010833 active site 366394010834 acyl carrier protein; Provisional; Region: acpP; PRK00982 366394010835 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 366394010836 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 366394010837 dimer interface [polypeptide binding]; other site 366394010838 active site 366394010839 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 366394010840 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 366394010841 dimerization interface [polypeptide binding]; other site 366394010842 hypothetical protein; Provisional; Region: PRK07524 366394010843 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 366394010844 PYR/PP interface [polypeptide binding]; other site 366394010845 dimer interface [polypeptide binding]; other site 366394010846 TPP binding site [chemical binding]; other site 366394010847 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 366394010848 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 366394010849 TPP-binding site [chemical binding]; other site 366394010850 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 366394010851 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 366394010852 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 366394010853 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 366394010854 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 366394010855 active site 366394010856 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 366394010857 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 366394010858 metal binding site [ion binding]; metal-binding site 366394010859 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 366394010860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394010861 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 366394010862 dimerization interface [polypeptide binding]; other site 366394010863 substrate binding pocket [chemical binding]; other site 366394010864 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394010865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394010866 Walker A/P-loop; other site 366394010867 ATP binding site [chemical binding]; other site 366394010868 Q-loop/lid; other site 366394010869 ABC transporter signature motif; other site 366394010870 Walker B; other site 366394010871 D-loop; other site 366394010872 H-loop/switch region; other site 366394010873 TOBE domain; Region: TOBE_2; pfam08402 366394010874 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 366394010875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394010876 dimer interface [polypeptide binding]; other site 366394010877 ABC-ATPase subunit interface; other site 366394010878 putative PBP binding loops; other site 366394010879 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394010880 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 366394010881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394010882 dimer interface [polypeptide binding]; other site 366394010883 conserved gate region; other site 366394010884 putative PBP binding loops; other site 366394010885 ABC-ATPase subunit interface; other site 366394010886 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 366394010887 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 366394010888 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 366394010889 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 366394010890 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 366394010891 catalytic site [active] 366394010892 G-X2-G-X-G-K; other site 366394010893 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 366394010894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394010895 S-adenosylmethionine binding site [chemical binding]; other site 366394010896 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 366394010897 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 366394010898 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 366394010899 SurA N-terminal domain; Region: SurA_N; pfam09312 366394010900 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 366394010901 Organic solvent tolerance protein; Region: OstA_C; pfam04453 366394010902 Predicted permeases [General function prediction only]; Region: COG0795 366394010903 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 366394010904 Predicted permeases [General function prediction only]; Region: COG0795 366394010905 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 366394010906 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 366394010907 multifunctional aminopeptidase A; Provisional; Region: PRK00913 366394010908 interface (dimer of trimers) [polypeptide binding]; other site 366394010909 Substrate-binding/catalytic site; other site 366394010910 Zn-binding sites [ion binding]; other site 366394010911 DNA polymerase III subunit chi; Validated; Region: PRK05728 366394010912 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394010913 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394010914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394010915 Coenzyme A binding pocket [chemical binding]; other site 366394010916 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 366394010917 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 366394010918 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 366394010919 ABC transporter; Region: ABC_tran_2; pfam12848 366394010920 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 366394010921 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 366394010922 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 366394010923 acyl-activating enzyme (AAE) consensus motif; other site 366394010924 AMP binding site [chemical binding]; other site 366394010925 active site 366394010926 CoA binding site [chemical binding]; other site 366394010927 Acyltransferase family; Region: Acyl_transf_3; pfam01757 366394010928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 366394010929 DinB superfamily; Region: DinB_2; pfam12867 366394010930 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 366394010931 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394010932 putative C-terminal domain interface [polypeptide binding]; other site 366394010933 putative GSH binding site (G-site) [chemical binding]; other site 366394010934 putative dimer interface [polypeptide binding]; other site 366394010935 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 366394010936 putative N-terminal domain interface [polypeptide binding]; other site 366394010937 putative dimer interface [polypeptide binding]; other site 366394010938 putative substrate binding pocket (H-site) [chemical binding]; other site 366394010939 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 366394010940 active site 366394010941 multimer interface [polypeptide binding]; other site 366394010942 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 366394010943 CGNR zinc finger; Region: zf-CGNR; pfam11706 366394010944 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 366394010945 TM-ABC transporter signature motif; other site 366394010946 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 366394010947 MoaE homodimer interface [polypeptide binding]; other site 366394010948 MoaD interaction [polypeptide binding]; other site 366394010949 active site residues [active] 366394010950 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 366394010951 MoaE interaction surface [polypeptide binding]; other site 366394010952 MoeB interaction surface [polypeptide binding]; other site 366394010953 thiocarboxylated glycine; other site 366394010954 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 366394010955 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 366394010956 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 366394010957 GIY-YIG motif/motif A; other site 366394010958 active site 366394010959 catalytic site [active] 366394010960 putative DNA binding site [nucleotide binding]; other site 366394010961 metal binding site [ion binding]; metal-binding site 366394010962 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 366394010963 short chain dehydrogenase; Provisional; Region: PRK09134 366394010964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394010965 NAD(P) binding site [chemical binding]; other site 366394010966 active site 366394010967 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 366394010968 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394010969 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 366394010970 putative C-terminal domain interface [polypeptide binding]; other site 366394010971 putative GSH binding site (G-site) [chemical binding]; other site 366394010972 putative dimer interface [polypeptide binding]; other site 366394010973 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 366394010974 N-terminal domain interface [polypeptide binding]; other site 366394010975 dimer interface [polypeptide binding]; other site 366394010976 putative substrate binding pocket (H-site) [chemical binding]; other site 366394010977 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 366394010978 B1 nucleotide binding pocket [chemical binding]; other site 366394010979 B2 nucleotide binding pocket [chemical binding]; other site 366394010980 CAS motifs; other site 366394010981 active site 366394010982 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 366394010983 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 366394010984 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 366394010985 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 366394010986 putative [4Fe-4S] binding site [ion binding]; other site 366394010987 putative molybdopterin cofactor binding site [chemical binding]; other site 366394010988 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 366394010989 putative molybdopterin cofactor binding site; other site 366394010990 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 366394010991 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 366394010992 dimer interface [polypeptide binding]; other site 366394010993 ADP-ribose binding site [chemical binding]; other site 366394010994 active site 366394010995 nudix motif; other site 366394010996 metal binding site [ion binding]; metal-binding site 366394010997 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 366394010998 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 366394010999 active site 366394011000 substrate binding site [chemical binding]; other site 366394011001 cosubstrate binding site; other site 366394011002 catalytic site [active] 366394011003 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 366394011004 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 366394011005 dimerization interface [polypeptide binding]; other site 366394011006 putative ATP binding site [chemical binding]; other site 366394011007 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 366394011008 Domain of unknown function DUF20; Region: UPF0118; pfam01594 366394011009 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 366394011010 hypothetical protein; Validated; Region: PRK09087 366394011011 polyphosphate kinase; Provisional; Region: PRK05443 366394011012 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 366394011013 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 366394011014 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 366394011015 putative domain interface [polypeptide binding]; other site 366394011016 putative active site [active] 366394011017 catalytic site [active] 366394011018 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 366394011019 putative domain interface [polypeptide binding]; other site 366394011020 putative active site [active] 366394011021 catalytic site [active] 366394011022 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 366394011023 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 366394011024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 366394011025 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394011026 cyclase homology domain; Region: CHD; cd07302 366394011027 nucleotidyl binding site; other site 366394011028 metal binding site [ion binding]; metal-binding site 366394011029 dimer interface [polypeptide binding]; other site 366394011030 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 366394011031 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 366394011032 catalytic site [active] 366394011033 putative active site [active] 366394011034 putative substrate binding site [chemical binding]; other site 366394011035 HRDC domain; Region: HRDC; cl02578 366394011036 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 366394011037 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 366394011038 Multicopper oxidase; Region: Cu-oxidase; pfam00394 366394011039 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 366394011040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394011041 putative substrate translocation pore; other site 366394011042 putative MFS family transporter protein; Provisional; Region: PRK03633 366394011043 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 366394011044 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 366394011045 dimer interface [polypeptide binding]; other site 366394011046 anticodon binding site; other site 366394011047 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 366394011048 homodimer interface [polypeptide binding]; other site 366394011049 motif 1; other site 366394011050 active site 366394011051 motif 2; other site 366394011052 GAD domain; Region: GAD; pfam02938 366394011053 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 366394011054 active site 366394011055 motif 3; other site 366394011056 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394011057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394011058 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394011059 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 366394011060 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 366394011061 ring oligomerisation interface [polypeptide binding]; other site 366394011062 ATP/Mg binding site [chemical binding]; other site 366394011063 stacking interactions; other site 366394011064 hinge regions; other site 366394011065 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 366394011066 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 366394011067 CAP-like domain; other site 366394011068 active site 366394011069 primary dimer interface [polypeptide binding]; other site 366394011070 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394011071 putative DNA binding site [nucleotide binding]; other site 366394011072 putative Zn2+ binding site [ion binding]; other site 366394011073 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 366394011074 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 366394011075 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 366394011076 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 366394011077 Predicted membrane protein/domain [Function unknown]; Region: COG1714 366394011078 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 366394011079 dimer interface [polypeptide binding]; other site 366394011080 allosteric magnesium binding site [ion binding]; other site 366394011081 active site 366394011082 aspartate-rich active site metal binding site; other site 366394011083 Schiff base residues; other site 366394011084 Transcriptional regulators [Transcription]; Region: MarR; COG1846 366394011085 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 366394011086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 366394011087 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394011088 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394011089 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394011090 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 366394011091 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 366394011092 dimer interface [polypeptide binding]; other site 366394011093 active site 366394011094 glycine-pyridoxal phosphate binding site [chemical binding]; other site 366394011095 folate binding site [chemical binding]; other site 366394011096 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 366394011097 ATP cone domain; Region: ATP-cone; pfam03477 366394011098 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 366394011099 catalytic motif [active] 366394011100 Zn binding site [ion binding]; other site 366394011101 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 366394011102 RibD C-terminal domain; Region: RibD_C; cl17279 366394011103 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 366394011104 Lumazine binding domain; Region: Lum_binding; pfam00677 366394011105 Lumazine binding domain; Region: Lum_binding; pfam00677 366394011106 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 366394011107 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 366394011108 homopentamer interface [polypeptide binding]; other site 366394011109 active site 366394011110 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 366394011111 putative RNA binding site [nucleotide binding]; other site 366394011112 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 366394011113 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 366394011114 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 366394011115 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 366394011116 Uncharacterized conserved protein [Function unknown]; Region: COG5452 366394011117 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 366394011118 putative phosphate acyltransferase; Provisional; Region: PRK05331 366394011119 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 366394011120 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 366394011121 dimer interface [polypeptide binding]; other site 366394011122 active site 366394011123 CoA binding pocket [chemical binding]; other site 366394011124 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 366394011125 IHF dimer interface [polypeptide binding]; other site 366394011126 IHF - DNA interface [nucleotide binding]; other site 366394011127 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 366394011128 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 366394011129 DNA binding residues [nucleotide binding] 366394011130 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 366394011131 salt bridge; other site 366394011132 non-specific DNA binding site [nucleotide binding]; other site 366394011133 sequence-specific DNA binding site [nucleotide binding]; other site 366394011134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394011135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394011136 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 366394011137 putative effector binding pocket; other site 366394011138 putative dimerization interface [polypeptide binding]; other site 366394011139 Uncharacterized conserved protein [Function unknown]; Region: COG1359 366394011140 Uncharacterized conserved protein [Function unknown]; Region: COG1359 366394011141 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394011142 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394011143 active site 366394011144 catalytic tetrad [active] 366394011145 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 366394011146 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 366394011147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4334 366394011148 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 366394011149 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 366394011150 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 366394011151 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 366394011152 L-idonate 5-dehydrogenase; Region: PLN02702 366394011153 inhibitor binding site; inhibition site 366394011154 catalytic Zn binding site [ion binding]; other site 366394011155 structural Zn binding site [ion binding]; other site 366394011156 NADP binding site [chemical binding]; other site 366394011157 tetramer interface [polypeptide binding]; other site 366394011158 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 366394011159 O-Antigen ligase; Region: Wzy_C; pfam04932 366394011160 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 366394011161 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 366394011162 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 366394011163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394011164 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 366394011165 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 366394011166 SLBB domain; Region: SLBB; pfam10531 366394011167 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 366394011168 Chain length determinant protein; Region: Wzz; pfam02706 366394011169 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 366394011170 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 366394011171 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 366394011172 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 366394011173 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 366394011174 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 366394011175 active site 366394011176 metal binding site [ion binding]; metal-binding site 366394011177 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 366394011178 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 366394011179 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 366394011180 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 366394011181 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 366394011182 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 366394011183 agmatinase; Region: agmatinase; TIGR01230 366394011184 oligomer interface [polypeptide binding]; other site 366394011185 putative active site [active] 366394011186 Mn binding site [ion binding]; other site 366394011187 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 366394011188 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 366394011189 23S rRNA interface [nucleotide binding]; other site 366394011190 L3 interface [polypeptide binding]; other site 366394011191 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 366394011192 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 366394011193 CoenzymeA binding site [chemical binding]; other site 366394011194 subunit interaction site [polypeptide binding]; other site 366394011195 PHB binding site; other site 366394011196 enoyl-CoA hydratase; Validated; Region: PRK08139 366394011197 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 366394011198 substrate binding site [chemical binding]; other site 366394011199 oxyanion hole (OAH) forming residues; other site 366394011200 trimer interface [polypeptide binding]; other site 366394011201 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 366394011202 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 366394011203 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 366394011204 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 366394011205 homodimer interface [polypeptide binding]; other site 366394011206 substrate-cofactor binding pocket; other site 366394011207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394011208 catalytic residue [active] 366394011209 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 366394011210 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 366394011211 Cytochrome P450; Region: p450; cl12078 366394011212 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 366394011213 putative catalytic site [active] 366394011214 putative metal binding site [ion binding]; other site 366394011215 putative phosphate binding site [ion binding]; other site 366394011216 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 366394011217 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 366394011218 putative active site [active] 366394011219 catalytic site [active] 366394011220 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 366394011221 putative active site [active] 366394011222 catalytic site [active] 366394011223 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 366394011224 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 366394011225 oligomer interface [polypeptide binding]; other site 366394011226 active site residues [active] 366394011227 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 366394011228 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 366394011229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394011230 Walker A motif; other site 366394011231 ATP binding site [chemical binding]; other site 366394011232 Walker B motif; other site 366394011233 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 366394011234 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 366394011235 Found in ATP-dependent protease La (LON); Region: LON; smart00464 366394011236 Found in ATP-dependent protease La (LON); Region: LON; smart00464 366394011237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394011238 Walker A motif; other site 366394011239 ATP binding site [chemical binding]; other site 366394011240 Walker B motif; other site 366394011241 arginine finger; other site 366394011242 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 366394011243 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 366394011244 IHF dimer interface [polypeptide binding]; other site 366394011245 IHF - DNA interface [nucleotide binding]; other site 366394011246 Uncharacterized conserved protein [Function unknown]; Region: COG3391 366394011247 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 366394011248 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 366394011249 MarR family; Region: MarR; pfam01047 366394011250 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 366394011251 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 366394011252 active site 366394011253 metal binding site [ion binding]; metal-binding site 366394011254 DNA binding site [nucleotide binding] 366394011255 Uncharacterized conserved protein [Function unknown]; Region: COG4717 366394011256 P-loop containing region of AAA domain; Region: AAA_29; cl17516 366394011257 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 366394011258 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 366394011259 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 366394011260 putative active site [active] 366394011261 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 366394011262 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394011263 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 366394011264 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 366394011265 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 366394011266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394011267 Walker A/P-loop; other site 366394011268 ATP binding site [chemical binding]; other site 366394011269 Q-loop/lid; other site 366394011270 ABC transporter signature motif; other site 366394011271 Walker B; other site 366394011272 D-loop; other site 366394011273 H-loop/switch region; other site 366394011274 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 366394011275 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 366394011276 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 366394011277 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 366394011278 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 366394011279 NADH dehydrogenase subunit D; Validated; Region: PRK06075 366394011280 NADH dehydrogenase subunit E; Validated; Region: PRK07539 366394011281 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 366394011282 putative dimer interface [polypeptide binding]; other site 366394011283 [2Fe-2S] cluster binding site [ion binding]; other site 366394011284 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 366394011285 SLBB domain; Region: SLBB; pfam10531 366394011286 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 366394011287 Uncharacterized conserved protein [Function unknown]; Region: COG3743 366394011288 NADH dehydrogenase subunit G; Validated; Region: PRK09130 366394011289 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394011290 catalytic loop [active] 366394011291 iron binding site [ion binding]; other site 366394011292 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 366394011293 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 366394011294 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 366394011295 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 366394011296 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 366394011297 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 366394011298 4Fe-4S binding domain; Region: Fer4; pfam00037 366394011299 4Fe-4S binding domain; Region: Fer4; pfam00037 366394011300 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 366394011301 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 366394011302 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 366394011303 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 366394011304 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 366394011305 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 366394011306 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 366394011307 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 366394011308 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 366394011309 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 366394011310 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 366394011311 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 366394011312 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 366394011313 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 366394011314 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 366394011315 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 366394011316 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394011317 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 366394011318 dimer interface [polypeptide binding]; other site 366394011319 substrate binding site [chemical binding]; other site 366394011320 metal binding site [ion binding]; metal-binding site 366394011321 Protein of unknown function (DUF1467); Region: DUF1467; cl11569 366394011322 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 366394011323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 366394011324 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394011325 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 366394011326 [2Fe-2S] cluster binding site [ion binding]; other site 366394011327 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 366394011328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394011329 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 366394011330 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 366394011331 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394011332 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394011333 TM-ABC transporter signature motif; other site 366394011334 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 366394011335 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394011336 Walker A/P-loop; other site 366394011337 ATP binding site [chemical binding]; other site 366394011338 Q-loop/lid; other site 366394011339 ABC transporter signature motif; other site 366394011340 Walker B; other site 366394011341 D-loop; other site 366394011342 H-loop/switch region; other site 366394011343 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 366394011344 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 366394011345 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394011346 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394011347 DNA binding site [nucleotide binding] 366394011348 domain linker motif; other site 366394011349 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 366394011350 putative ligand binding site [chemical binding]; other site 366394011351 prolyl-tRNA synthetase; Provisional; Region: PRK12325 366394011352 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 366394011353 dimer interface [polypeptide binding]; other site 366394011354 motif 1; other site 366394011355 active site 366394011356 motif 2; other site 366394011357 motif 3; other site 366394011358 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 366394011359 anticodon binding site; other site 366394011360 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 366394011361 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 366394011362 FtsX-like permease family; Region: FtsX; pfam02687 366394011363 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 366394011364 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 366394011365 Walker A/P-loop; other site 366394011366 ATP binding site [chemical binding]; other site 366394011367 Q-loop/lid; other site 366394011368 ABC transporter signature motif; other site 366394011369 Walker B; other site 366394011370 D-loop; other site 366394011371 H-loop/switch region; other site 366394011372 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 366394011373 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 366394011374 putative active site [active] 366394011375 putative PHP Thumb interface [polypeptide binding]; other site 366394011376 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 366394011377 generic binding surface II; other site 366394011378 generic binding surface I; other site 366394011379 hypothetical protein; Provisional; Region: PRK06132 366394011380 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394011381 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394011382 DNA polymerase IV; Provisional; Region: PRK02794 366394011383 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 366394011384 active site 366394011385 DNA binding site [nucleotide binding] 366394011386 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 366394011387 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 366394011388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394011389 active site 366394011390 phosphorylation site [posttranslational modification] 366394011391 intermolecular recognition site; other site 366394011392 dimerization interface [polypeptide binding]; other site 366394011393 response regulator PleD; Reviewed; Region: pleD; PRK09581 366394011394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394011395 active site 366394011396 phosphorylation site [posttranslational modification] 366394011397 intermolecular recognition site; other site 366394011398 dimerization interface [polypeptide binding]; other site 366394011399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394011400 active site 366394011401 phosphorylation site [posttranslational modification] 366394011402 intermolecular recognition site; other site 366394011403 dimerization interface [polypeptide binding]; other site 366394011404 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394011405 metal binding site [ion binding]; metal-binding site 366394011406 active site 366394011407 I-site; other site 366394011408 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 366394011409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394011410 putative substrate translocation pore; other site 366394011411 Major Facilitator Superfamily; Region: MFS_1; pfam07690 366394011412 hypothetical protein; Provisional; Region: PRK05978 366394011413 ribonuclease R; Region: RNase_R; TIGR02063 366394011414 RNB domain; Region: RNB; pfam00773 366394011415 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 366394011416 RNA binding site [nucleotide binding]; other site 366394011417 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 366394011418 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 366394011419 active site 366394011420 interdomain interaction site; other site 366394011421 putative metal-binding site [ion binding]; other site 366394011422 nucleotide binding site [chemical binding]; other site 366394011423 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 366394011424 domain I; other site 366394011425 DNA binding groove [nucleotide binding] 366394011426 phosphate binding site [ion binding]; other site 366394011427 domain II; other site 366394011428 domain III; other site 366394011429 nucleotide binding site [chemical binding]; other site 366394011430 catalytic site [active] 366394011431 domain IV; other site 366394011432 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 366394011433 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 366394011434 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 366394011435 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 366394011436 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 366394011437 DNA protecting protein DprA; Region: dprA; TIGR00732 366394011438 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 366394011439 dihydroorotase; Validated; Region: PRK09059 366394011440 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 366394011441 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 366394011442 active site 366394011443 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 366394011444 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 366394011445 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 366394011446 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 366394011447 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 366394011448 active site 366394011449 Predicted permeases [General function prediction only]; Region: COG0679 366394011450 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 366394011451 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 366394011452 metal-dependent hydrolase; Provisional; Region: PRK00685 366394011453 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 366394011454 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 366394011455 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 366394011456 hypothetical protein; Provisional; Region: PRK13687 366394011457 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 366394011458 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 366394011459 GatB domain; Region: GatB_Yqey; smart00845 366394011460 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 366394011461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394011462 Coenzyme A binding pocket [chemical binding]; other site 366394011463 NADH dehydrogenase; Validated; Region: PRK08183 366394011464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 366394011465 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 366394011466 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 366394011467 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 366394011468 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 366394011469 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 366394011470 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 366394011471 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 366394011472 carboxyltransferase (CT) interaction site; other site 366394011473 biotinylation site [posttranslational modification]; other site 366394011474 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 366394011475 Dehydroquinase class II; Region: DHquinase_II; pfam01220 366394011476 trimer interface [polypeptide binding]; other site 366394011477 active site 366394011478 dimer interface [polypeptide binding]; other site 366394011479 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 366394011480 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 366394011481 catalytic residues [active] 366394011482 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 366394011483 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 366394011484 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 366394011485 AMIN domain; Region: AMIN; pfam11741 366394011486 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 366394011487 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 366394011488 active site 366394011489 metal binding site [ion binding]; metal-binding site 366394011490 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 366394011491 Transglycosylase; Region: Transgly; pfam00912 366394011492 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 366394011493 peptide chain release factor 2; Provisional; Region: PRK07342 366394011494 This domain is found in peptide chain release factors; Region: PCRF; smart00937 366394011495 RF-1 domain; Region: RF-1; pfam00472 366394011496 ATP-NAD kinase; Region: NAD_kinase; pfam01513 366394011497 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 366394011498 LysR family transcriptional regulator; Provisional; Region: PRK14997 366394011499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394011500 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 366394011501 putative effector binding pocket; other site 366394011502 putative dimerization interface [polypeptide binding]; other site 366394011503 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 366394011504 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 366394011505 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 366394011506 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 366394011507 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 366394011508 elongation factor Tu; Reviewed; Region: PRK00049 366394011509 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 366394011510 G1 box; other site 366394011511 GEF interaction site [polypeptide binding]; other site 366394011512 GTP/Mg2+ binding site [chemical binding]; other site 366394011513 Switch I region; other site 366394011514 G2 box; other site 366394011515 G3 box; other site 366394011516 Switch II region; other site 366394011517 G4 box; other site 366394011518 G5 box; other site 366394011519 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 366394011520 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 366394011521 Antibiotic Binding Site [chemical binding]; other site 366394011522 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394011523 extended (e) SDRs; Region: SDR_e; cd08946 366394011524 NAD(P) binding site [chemical binding]; other site 366394011525 active site 366394011526 substrate binding site [chemical binding]; other site 366394011527 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 366394011528 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 366394011529 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 366394011530 putative homodimer interface [polypeptide binding]; other site 366394011531 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 366394011532 heterodimer interface [polypeptide binding]; other site 366394011533 homodimer interface [polypeptide binding]; other site 366394011534 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 366394011535 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 366394011536 23S rRNA interface [nucleotide binding]; other site 366394011537 L7/L12 interface [polypeptide binding]; other site 366394011538 putative thiostrepton binding site; other site 366394011539 L25 interface [polypeptide binding]; other site 366394011540 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 366394011541 mRNA/rRNA interface [nucleotide binding]; other site 366394011542 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 366394011543 23S rRNA interface [nucleotide binding]; other site 366394011544 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 366394011545 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 366394011546 core dimer interface [polypeptide binding]; other site 366394011547 peripheral dimer interface [polypeptide binding]; other site 366394011548 L10 interface [polypeptide binding]; other site 366394011549 L11 interface [polypeptide binding]; other site 366394011550 putative EF-Tu interaction site [polypeptide binding]; other site 366394011551 putative EF-G interaction site [polypeptide binding]; other site 366394011552 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 366394011553 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 366394011554 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 366394011555 RPB11 interaction site [polypeptide binding]; other site 366394011556 RPB12 interaction site [polypeptide binding]; other site 366394011557 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 366394011558 RPB1 interaction site [polypeptide binding]; other site 366394011559 RPB11 interaction site [polypeptide binding]; other site 366394011560 RPB10 interaction site [polypeptide binding]; other site 366394011561 RPB3 interaction site [polypeptide binding]; other site 366394011562 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 366394011563 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 366394011564 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 366394011565 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 366394011566 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 366394011567 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 366394011568 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 366394011569 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 366394011570 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 366394011571 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 366394011572 DNA binding site [nucleotide binding] 366394011573 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 366394011574 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 366394011575 S17 interaction site [polypeptide binding]; other site 366394011576 S8 interaction site; other site 366394011577 16S rRNA interaction site [nucleotide binding]; other site 366394011578 streptomycin interaction site [chemical binding]; other site 366394011579 23S rRNA interaction site [nucleotide binding]; other site 366394011580 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 366394011581 30S ribosomal protein S7; Validated; Region: PRK05302 366394011582 elongation factor G; Reviewed; Region: PRK00007 366394011583 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 366394011584 G1 box; other site 366394011585 putative GEF interaction site [polypeptide binding]; other site 366394011586 GTP/Mg2+ binding site [chemical binding]; other site 366394011587 Switch I region; other site 366394011588 G2 box; other site 366394011589 G3 box; other site 366394011590 Switch II region; other site 366394011591 G4 box; other site 366394011592 G5 box; other site 366394011593 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 366394011594 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 366394011595 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 366394011596 elongation factor Tu; Reviewed; Region: PRK00049 366394011597 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 366394011598 G1 box; other site 366394011599 GEF interaction site [polypeptide binding]; other site 366394011600 GTP/Mg2+ binding site [chemical binding]; other site 366394011601 Switch I region; other site 366394011602 G2 box; other site 366394011603 G3 box; other site 366394011604 Switch II region; other site 366394011605 G4 box; other site 366394011606 G5 box; other site 366394011607 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 366394011608 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 366394011609 Antibiotic Binding Site [chemical binding]; other site 366394011610 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 366394011611 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 366394011612 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 366394011613 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 366394011614 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 366394011615 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 366394011616 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 366394011617 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 366394011618 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 366394011619 putative translocon binding site; other site 366394011620 protein-rRNA interface [nucleotide binding]; other site 366394011621 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 366394011622 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 366394011623 G-X-X-G motif; other site 366394011624 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 366394011625 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 366394011626 23S rRNA interface [nucleotide binding]; other site 366394011627 5S rRNA interface [nucleotide binding]; other site 366394011628 putative antibiotic binding site [chemical binding]; other site 366394011629 L25 interface [polypeptide binding]; other site 366394011630 L27 interface [polypeptide binding]; other site 366394011631 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 366394011632 23S rRNA interface [nucleotide binding]; other site 366394011633 putative translocon interaction site; other site 366394011634 signal recognition particle (SRP54) interaction site; other site 366394011635 L23 interface [polypeptide binding]; other site 366394011636 trigger factor interaction site; other site 366394011637 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 366394011638 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 366394011639 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 366394011640 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 366394011641 RNA binding site [nucleotide binding]; other site 366394011642 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 366394011643 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 366394011644 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 366394011645 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 366394011646 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 366394011647 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 366394011648 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 366394011649 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 366394011650 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 366394011651 23S rRNA interface [nucleotide binding]; other site 366394011652 L21e interface [polypeptide binding]; other site 366394011653 5S rRNA interface [nucleotide binding]; other site 366394011654 L27 interface [polypeptide binding]; other site 366394011655 L5 interface [polypeptide binding]; other site 366394011656 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 366394011657 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 366394011658 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 366394011659 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 366394011660 23S rRNA binding site [nucleotide binding]; other site 366394011661 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 366394011662 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 366394011663 SecY translocase; Region: SecY; pfam00344 366394011664 adenylate kinase; Reviewed; Region: adk; PRK00279 366394011665 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 366394011666 AMP-binding site [chemical binding]; other site 366394011667 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 366394011668 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 366394011669 30S ribosomal protein S13; Region: bact_S13; TIGR03631 366394011670 30S ribosomal protein S11; Validated; Region: PRK05309 366394011671 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 366394011672 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 366394011673 alphaNTD homodimer interface [polypeptide binding]; other site 366394011674 alphaNTD - beta interaction site [polypeptide binding]; other site 366394011675 alphaNTD - beta' interaction site [polypeptide binding]; other site 366394011676 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 366394011677 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 366394011678 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 366394011679 TMAO/DMSO reductase; Reviewed; Region: PRK05363 366394011680 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 366394011681 Moco binding site; other site 366394011682 metal coordination site [ion binding]; other site 366394011683 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 366394011684 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 366394011685 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 366394011686 protein binding site [polypeptide binding]; other site 366394011687 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 366394011688 protein binding site [polypeptide binding]; other site 366394011689 recombination factor protein RarA; Reviewed; Region: PRK13342 366394011690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394011691 Walker A motif; other site 366394011692 ATP binding site [chemical binding]; other site 366394011693 Walker B motif; other site 366394011694 arginine finger; other site 366394011695 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 366394011696 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 366394011697 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 366394011698 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 366394011699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394011700 motif II; other site 366394011701 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 366394011702 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 366394011703 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 366394011704 active site 366394011705 camphor resistance protein CrcB; Provisional; Region: PRK14195 366394011706 S-formylglutathione hydrolase; Region: PLN02442 366394011707 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 366394011708 Predicted membrane protein [Function unknown]; Region: COG4291 366394011709 hypothetical protein; Validated; Region: PRK00124 366394011710 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 366394011711 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 366394011712 substrate binding site [chemical binding]; other site 366394011713 catalytic Zn binding site [ion binding]; other site 366394011714 NAD binding site [chemical binding]; other site 366394011715 structural Zn binding site [ion binding]; other site 366394011716 dimer interface [polypeptide binding]; other site 366394011717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394011718 non-specific DNA binding site [nucleotide binding]; other site 366394011719 salt bridge; other site 366394011720 sequence-specific DNA binding site [nucleotide binding]; other site 366394011721 lipoate-protein ligase B; Provisional; Region: PRK14341 366394011722 PrkA family serine protein kinase; Provisional; Region: PRK15455 366394011723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 366394011724 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 366394011725 Uncharacterized conserved protein [Function unknown]; Region: COG2718 366394011726 SpoVR family protein; Provisional; Region: PRK11767 366394011727 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 366394011728 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 366394011729 active site 366394011730 catalytic residues [active] 366394011731 metal binding site [ion binding]; metal-binding site 366394011732 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 366394011733 MgtE intracellular N domain; Region: MgtE_N; smart00924 366394011734 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 366394011735 Divalent cation transporter; Region: MgtE; cl00786 366394011736 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 366394011737 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 366394011738 DNA binding residues [nucleotide binding] 366394011739 putative dimer interface [polypeptide binding]; other site 366394011740 Predicted membrane protein [Function unknown]; Region: COG3503 366394011741 Predicted membrane protein [Function unknown]; Region: COG3821 366394011742 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 366394011743 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 366394011744 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 366394011745 Uncharacterized conserved protein [Function unknown]; Region: COG5458 366394011746 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 366394011747 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 366394011748 Sporulation related domain; Region: SPOR; pfam05036 366394011749 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 366394011750 PilZ domain; Region: PilZ; pfam07238 366394011751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 366394011752 PAS domain; Region: PAS_5; pfam07310 366394011753 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 366394011754 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 366394011755 FOG: CBS domain [General function prediction only]; Region: COG0517 366394011756 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 366394011757 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 366394011758 nucleophile elbow; other site 366394011759 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 366394011760 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 366394011761 GTP cyclohydrolase I; Provisional; Region: PLN03044 366394011762 active site 366394011763 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 366394011764 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 366394011765 trimerization site [polypeptide binding]; other site 366394011766 active site 366394011767 hypothetical protein; Validated; Region: PRK00041 366394011768 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 366394011769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 366394011770 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 366394011771 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 366394011772 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 366394011773 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 366394011774 active site 366394011775 dimer interface [polypeptide binding]; other site 366394011776 motif 1; other site 366394011777 motif 2; other site 366394011778 motif 3; other site 366394011779 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 366394011780 anticodon binding site; other site 366394011781 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 366394011782 putative FMN binding site [chemical binding]; other site 366394011783 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 366394011784 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 366394011785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 366394011786 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 366394011787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394011788 Coenzyme A binding pocket [chemical binding]; other site 366394011789 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 366394011790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394011791 Mg2+ binding site [ion binding]; other site 366394011792 G-X-G motif; other site 366394011793 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 366394011794 anchoring element; other site 366394011795 dimer interface [polypeptide binding]; other site 366394011796 ATP binding site [chemical binding]; other site 366394011797 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 366394011798 active site 366394011799 metal binding site [ion binding]; metal-binding site 366394011800 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 366394011801 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 366394011802 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 366394011803 FAD binding domain; Region: FAD_binding_4; pfam01565 366394011804 Uncharacterized conserved protein [Function unknown]; Region: COG2353 366394011805 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 366394011806 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 366394011807 triosephosphate isomerase; Provisional; Region: PRK14565 366394011808 substrate binding site [chemical binding]; other site 366394011809 dimer interface [polypeptide binding]; other site 366394011810 catalytic triad [active] 366394011811 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 366394011812 CTP synthetase; Validated; Region: pyrG; PRK05380 366394011813 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 366394011814 Catalytic site [active] 366394011815 active site 366394011816 UTP binding site [chemical binding]; other site 366394011817 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 366394011818 active site 366394011819 putative oxyanion hole; other site 366394011820 catalytic triad [active] 366394011821 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 366394011822 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 366394011823 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 366394011824 enolase; Provisional; Region: eno; PRK00077 366394011825 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 366394011826 dimer interface [polypeptide binding]; other site 366394011827 metal binding site [ion binding]; metal-binding site 366394011828 substrate binding pocket [chemical binding]; other site 366394011829 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 366394011830 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 366394011831 Septum formation initiator; Region: DivIC; pfam04977 366394011832 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 366394011833 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 366394011834 tetramer interface [polypeptide binding]; other site 366394011835 TPP-binding site [chemical binding]; other site 366394011836 heterodimer interface [polypeptide binding]; other site 366394011837 phosphorylation loop region [posttranslational modification] 366394011838 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 366394011839 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 366394011840 E3 interaction surface; other site 366394011841 lipoyl attachment site [posttranslational modification]; other site 366394011842 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 366394011843 alpha subunit interface [polypeptide binding]; other site 366394011844 TPP binding site [chemical binding]; other site 366394011845 heterodimer interface [polypeptide binding]; other site 366394011846 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 366394011847 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 366394011848 E3 interaction surface; other site 366394011849 lipoyl attachment site [posttranslational modification]; other site 366394011850 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 366394011851 e3 binding domain; Region: E3_binding; pfam02817 366394011852 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 366394011853 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 366394011854 active site 366394011855 catalytic triad [active] 366394011856 oxyanion hole [active] 366394011857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 366394011858 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 366394011859 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 366394011860 Coenzyme A binding pocket [chemical binding]; other site 366394011861 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 366394011862 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 366394011863 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394011864 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 366394011865 Predicted membrane protein [Function unknown]; Region: COG2261 366394011866 lipoyl synthase; Provisional; Region: PRK05481 366394011867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 366394011868 FeS/SAM binding site; other site 366394011869 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 366394011870 putative coenzyme Q binding site [chemical binding]; other site 366394011871 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 366394011872 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 366394011873 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 366394011874 substrate binding site; other site 366394011875 dimer interface; other site 366394011876 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 366394011877 homotrimer interaction site [polypeptide binding]; other site 366394011878 zinc binding site [ion binding]; other site 366394011879 CDP-binding sites; other site 366394011880 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 366394011881 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 366394011882 FMN binding site [chemical binding]; other site 366394011883 active site 366394011884 catalytic residues [active] 366394011885 substrate binding site [chemical binding]; other site 366394011886 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 366394011887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394011888 dimer interface [polypeptide binding]; other site 366394011889 phosphorylation site [posttranslational modification] 366394011890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394011891 ATP binding site [chemical binding]; other site 366394011892 Mg2+ binding site [ion binding]; other site 366394011893 G-X-G motif; other site 366394011894 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 366394011895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394011896 active site 366394011897 phosphorylation site [posttranslational modification] 366394011898 intermolecular recognition site; other site 366394011899 dimerization interface [polypeptide binding]; other site 366394011900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394011901 Walker A motif; other site 366394011902 ATP binding site [chemical binding]; other site 366394011903 Walker B motif; other site 366394011904 arginine finger; other site 366394011905 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 366394011906 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 366394011907 HAMP domain; Region: HAMP; pfam00672 366394011908 dimerization interface [polypeptide binding]; other site 366394011909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394011910 dimer interface [polypeptide binding]; other site 366394011911 phosphorylation site [posttranslational modification] 366394011912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394011913 ATP binding site [chemical binding]; other site 366394011914 Mg2+ binding site [ion binding]; other site 366394011915 G-X-G motif; other site 366394011916 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 366394011917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394011918 active site 366394011919 phosphorylation site [posttranslational modification] 366394011920 intermolecular recognition site; other site 366394011921 dimerization interface [polypeptide binding]; other site 366394011922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394011923 Walker A motif; other site 366394011924 ATP binding site [chemical binding]; other site 366394011925 Walker B motif; other site 366394011926 arginine finger; other site 366394011927 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 366394011928 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 366394011929 TrkA-N domain; Region: TrkA_N; pfam02254 366394011930 TrkA-C domain; Region: TrkA_C; pfam02080 366394011931 TrkA-N domain; Region: TrkA_N; pfam02254 366394011932 TrkA-C domain; Region: TrkA_C; pfam02080 366394011933 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 366394011934 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 366394011935 homodimer interface [polypeptide binding]; other site 366394011936 substrate-cofactor binding pocket; other site 366394011937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394011938 catalytic residue [active] 366394011939 bacterial Hfq-like; Region: Hfq; cd01716 366394011940 hexamer interface [polypeptide binding]; other site 366394011941 Sm1 motif; other site 366394011942 RNA binding site [nucleotide binding]; other site 366394011943 Sm2 motif; other site 366394011944 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 366394011945 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 366394011946 HflX GTPase family; Region: HflX; cd01878 366394011947 G1 box; other site 366394011948 GTP/Mg2+ binding site [chemical binding]; other site 366394011949 Switch I region; other site 366394011950 G2 box; other site 366394011951 G3 box; other site 366394011952 Switch II region; other site 366394011953 G4 box; other site 366394011954 G5 box; other site 366394011955 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 366394011956 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 366394011957 homodimer interface [polypeptide binding]; other site 366394011958 metal binding site [ion binding]; metal-binding site 366394011959 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 366394011960 homodimer interface [polypeptide binding]; other site 366394011961 active site 366394011962 putative chemical substrate binding site [chemical binding]; other site 366394011963 metal binding site [ion binding]; metal-binding site 366394011964 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 366394011965 nucleoside/Zn binding site; other site 366394011966 dimer interface [polypeptide binding]; other site 366394011967 catalytic motif [active] 366394011968 siroheme synthase; Provisional; Region: cysG; PRK10637 366394011969 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 366394011970 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 366394011971 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 366394011972 active site 366394011973 SAM binding site [chemical binding]; other site 366394011974 homodimer interface [polypeptide binding]; other site 366394011975 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 366394011976 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 366394011977 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 366394011978 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 366394011979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 366394011980 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 366394011981 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 366394011982 FAD binding pocket [chemical binding]; other site 366394011983 FAD binding motif [chemical binding]; other site 366394011984 phosphate binding motif [ion binding]; other site 366394011985 beta-alpha-beta structure motif; other site 366394011986 NAD binding pocket [chemical binding]; other site 366394011987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 366394011988 Helix-turn-helix domain; Region: HTH_28; pfam13518 366394011989 Homeodomain-like domain; Region: HTH_32; pfam13565 366394011990 DDE superfamily endonuclease; Region: DDE_3; pfam13358 366394011991 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 366394011992 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 366394011993 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 366394011994 Walker A/P-loop; other site 366394011995 ATP binding site [chemical binding]; other site 366394011996 Q-loop/lid; other site 366394011997 ABC transporter signature motif; other site 366394011998 Walker B; other site 366394011999 D-loop; other site 366394012000 H-loop/switch region; other site 366394012001 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 366394012002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394012003 dimer interface [polypeptide binding]; other site 366394012004 conserved gate region; other site 366394012005 putative PBP binding loops; other site 366394012006 ABC-ATPase subunit interface; other site 366394012007 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 366394012008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 366394012009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394012010 dimer interface [polypeptide binding]; other site 366394012011 conserved gate region; other site 366394012012 putative PBP binding loops; other site 366394012013 ABC-ATPase subunit interface; other site 366394012014 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 366394012015 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394012016 substrate binding pocket [chemical binding]; other site 366394012017 membrane-bound complex binding site; other site 366394012018 hinge residues; other site 366394012019 cystathionine beta-lyase; Provisional; Region: PRK05967 366394012020 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 366394012021 homodimer interface [polypeptide binding]; other site 366394012022 substrate-cofactor binding pocket; other site 366394012023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394012024 catalytic residue [active] 366394012025 salicylate hydroxylase; Provisional; Region: PRK08163 366394012026 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 366394012027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 366394012028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 366394012029 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 366394012030 serine acetyltransferase; Provisional; Region: cysE; PRK11132 366394012031 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 366394012032 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 366394012033 trimer interface [polypeptide binding]; other site 366394012034 active site 366394012035 substrate binding site [chemical binding]; other site 366394012036 CoA binding site [chemical binding]; other site 366394012037 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 366394012038 Phasin protein; Region: Phasin_2; pfam09361 366394012039 Uncharacterized conserved protein [Function unknown]; Region: COG2127 366394012040 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 366394012041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394012042 Walker A motif; other site 366394012043 ATP binding site [chemical binding]; other site 366394012044 Walker B motif; other site 366394012045 arginine finger; other site 366394012046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394012047 Walker A motif; other site 366394012048 ATP binding site [chemical binding]; other site 366394012049 Walker B motif; other site 366394012050 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 366394012051 AzlC protein; Region: AzlC; pfam03591 366394012052 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 366394012053 HIT family signature motif; other site 366394012054 catalytic residue [active] 366394012055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 366394012056 Protein of unknown function, DUF482; Region: DUF482; pfam04339 366394012057 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 366394012058 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 366394012059 putative active site [active] 366394012060 catalytic site [active] 366394012061 putative metal binding site [ion binding]; other site 366394012062 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 366394012063 homotrimer interaction site [polypeptide binding]; other site 366394012064 putative active site [active] 366394012065 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 366394012066 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 366394012067 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 366394012068 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 366394012069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394012070 dimer interface [polypeptide binding]; other site 366394012071 conserved gate region; other site 366394012072 putative PBP binding loops; other site 366394012073 ABC-ATPase subunit interface; other site 366394012074 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 366394012075 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 366394012076 Walker A/P-loop; other site 366394012077 ATP binding site [chemical binding]; other site 366394012078 Q-loop/lid; other site 366394012079 ABC transporter signature motif; other site 366394012080 Walker B; other site 366394012081 D-loop; other site 366394012082 H-loop/switch region; other site 366394012083 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 366394012084 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394012085 substrate binding pocket [chemical binding]; other site 366394012086 membrane-bound complex binding site; other site 366394012087 hinge residues; other site 366394012088 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 366394012089 Sulfatase; Region: Sulfatase; cl17466 366394012090 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 366394012091 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 366394012092 rRNA interaction site [nucleotide binding]; other site 366394012093 S8 interaction site; other site 366394012094 putative laminin-1 binding site; other site 366394012095 elongation factor Ts; Provisional; Region: tsf; PRK09377 366394012096 UBA/TS-N domain; Region: UBA; pfam00627 366394012097 Elongation factor TS; Region: EF_TS; pfam00889 366394012098 Elongation factor TS; Region: EF_TS; pfam00889 366394012099 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 366394012100 putative nucleotide binding site [chemical binding]; other site 366394012101 uridine monophosphate binding site [chemical binding]; other site 366394012102 homohexameric interface [polypeptide binding]; other site 366394012103 ribosome recycling factor; Reviewed; Region: frr; PRK00083 366394012104 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 366394012105 hinge region; other site 366394012106 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 366394012107 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 366394012108 catalytic residue [active] 366394012109 putative FPP diphosphate binding site; other site 366394012110 putative FPP binding hydrophobic cleft; other site 366394012111 dimer interface [polypeptide binding]; other site 366394012112 putative IPP diphosphate binding site; other site 366394012113 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 366394012114 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 366394012115 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 366394012116 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 366394012117 active site 366394012118 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 366394012119 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 366394012120 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 366394012121 putative substrate binding region [chemical binding]; other site 366394012122 putative substrate binding region [chemical binding]; other site 366394012123 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 366394012124 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 366394012125 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 366394012126 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 366394012127 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 366394012128 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 366394012129 Surface antigen; Region: Bac_surface_Ag; pfam01103 366394012130 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 366394012131 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 366394012132 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 366394012133 trimer interface [polypeptide binding]; other site 366394012134 active site 366394012135 UDP-GlcNAc binding site [chemical binding]; other site 366394012136 lipid binding site [chemical binding]; lipid-binding site 366394012137 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 366394012138 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 366394012139 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 366394012140 active site 366394012141 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 366394012142 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 366394012143 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 366394012144 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 366394012145 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 366394012146 dimer interface [polypeptide binding]; other site 366394012147 active site 366394012148 citrylCoA binding site [chemical binding]; other site 366394012149 NADH binding [chemical binding]; other site 366394012150 cationic pore residues; other site 366394012151 oxalacetate/citrate binding site [chemical binding]; other site 366394012152 coenzyme A binding site [chemical binding]; other site 366394012153 catalytic triad [active] 366394012154 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 366394012155 Competence protein; Region: Competence; pfam03772 366394012156 tonB-system energizer ExbB; Region: exbB; TIGR02797 366394012157 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 366394012158 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 366394012159 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 366394012160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 366394012161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394012162 S-adenosylmethionine binding site [chemical binding]; other site 366394012163 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 366394012164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 366394012165 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 366394012166 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 366394012167 HIGH motif; other site 366394012168 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 366394012169 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 366394012170 active site 366394012171 KMSKS motif; other site 366394012172 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 366394012173 tRNA binding surface [nucleotide binding]; other site 366394012174 anticodon binding site; other site 366394012175 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 366394012176 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 366394012177 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 366394012178 Sel1-like repeats; Region: SEL1; smart00671 366394012179 Sel1-like repeats; Region: SEL1; smart00671 366394012180 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 366394012181 putative catalytic site [active] 366394012182 putative phosphate binding site [ion binding]; other site 366394012183 active site 366394012184 metal binding site A [ion binding]; metal-binding site 366394012185 DNA binding site [nucleotide binding] 366394012186 putative AP binding site [nucleotide binding]; other site 366394012187 putative metal binding site B [ion binding]; other site 366394012188 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 366394012189 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 366394012190 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 366394012191 putative active site [active] 366394012192 catalytic site [active] 366394012193 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 366394012194 putative active site [active] 366394012195 catalytic site [active] 366394012196 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 366394012197 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 366394012198 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 366394012199 Zn2+ binding site [ion binding]; other site 366394012200 Mg2+ binding site [ion binding]; other site 366394012201 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 366394012202 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 366394012203 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 366394012204 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 366394012205 active site 366394012206 HIGH motif; other site 366394012207 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 366394012208 KMSK motif region; other site 366394012209 tRNA binding surface [nucleotide binding]; other site 366394012210 DALR anticodon binding domain; Region: DALR_1; smart00836 366394012211 anticodon binding site; other site 366394012212 Sporulation related domain; Region: SPOR; pfam05036 366394012213 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 366394012214 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 366394012215 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 366394012216 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 366394012217 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394012218 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 366394012219 Walker A/P-loop; other site 366394012220 ATP binding site [chemical binding]; other site 366394012221 Q-loop/lid; other site 366394012222 ABC transporter signature motif; other site 366394012223 Walker B; other site 366394012224 D-loop; other site 366394012225 H-loop/switch region; other site 366394012226 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 366394012227 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 366394012228 sec-independent translocase; Provisional; Region: PRK00708 366394012229 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 366394012230 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 366394012231 seryl-tRNA synthetase; Provisional; Region: PRK05431 366394012232 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 366394012233 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 366394012234 dimer interface [polypeptide binding]; other site 366394012235 active site 366394012236 motif 1; other site 366394012237 motif 2; other site 366394012238 motif 3; other site 366394012239 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 366394012240 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 366394012241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394012242 S-adenosylmethionine binding site [chemical binding]; other site 366394012243 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 366394012244 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 366394012245 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 366394012246 Peptidase family M23; Region: Peptidase_M23; pfam01551 366394012247 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 366394012248 Protein of unknown function (DUF815); Region: DUF815; pfam05673 366394012249 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 366394012250 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 366394012251 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 366394012252 Protein export membrane protein; Region: SecD_SecF; cl14618 366394012253 Protein export membrane protein; Region: SecD_SecF; pfam02355 366394012254 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 366394012255 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 366394012256 substrate binding pocket [chemical binding]; other site 366394012257 aspartate-rich region 1; other site 366394012258 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 366394012259 Glucose inhibited division protein A; Region: GIDA; pfam01134 366394012260 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 366394012261 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 366394012262 trigger factor; Provisional; Region: tig; PRK01490 366394012263 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 366394012264 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 366394012265 glycine dehydrogenase; Provisional; Region: PRK05367 366394012266 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 366394012267 tetramer interface [polypeptide binding]; other site 366394012268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394012269 catalytic residue [active] 366394012270 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 366394012271 tetramer interface [polypeptide binding]; other site 366394012272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394012273 catalytic residue [active] 366394012274 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 366394012275 lipoyl attachment site [posttranslational modification]; other site 366394012276 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 366394012277 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 366394012278 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 366394012279 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 366394012280 TniQ; Region: TniQ; pfam06527 366394012281 Bacterial TniB protein; Region: TniB; pfam05621 366394012282 AAA domain; Region: AAA_22; pfam13401 366394012283 Integrase core domain; Region: rve; pfam00665 366394012284 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 366394012285 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 366394012286 oligomeric interface; other site 366394012287 putative active site [active] 366394012288 homodimer interface [polypeptide binding]; other site 366394012289 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 366394012290 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 366394012291 DNA binding residues [nucleotide binding] 366394012292 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 366394012293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394012294 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 366394012295 Walker A motif; other site 366394012296 ATP binding site [chemical binding]; other site 366394012297 Walker B motif; other site 366394012298 arginine finger; other site 366394012299 Peptidase family M41; Region: Peptidase_M41; pfam01434 366394012300 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 366394012301 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 366394012302 cofactor binding site; other site 366394012303 DNA binding site [nucleotide binding] 366394012304 substrate interaction site [chemical binding]; other site 366394012305 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 366394012306 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 366394012307 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394012308 DNA binding site [nucleotide binding] 366394012309 Predicted ATPase [General function prediction only]; Region: COG3903 366394012310 Domain of unknown function (DUF336); Region: DUF336; cl01249 366394012311 short chain dehydrogenase; Provisional; Region: PRK09291 366394012312 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 366394012313 NADP binding site [chemical binding]; other site 366394012314 active site 366394012315 steroid binding site; other site 366394012316 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 366394012317 short chain dehydrogenase; Provisional; Region: PRK06180 366394012318 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 366394012319 NADP binding site [chemical binding]; other site 366394012320 active site 366394012321 steroid binding site; other site 366394012322 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 366394012323 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 366394012324 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 366394012325 TrkA-N domain; Region: TrkA_N; pfam02254 366394012326 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 366394012327 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 366394012328 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 366394012329 catalytic residue [active] 366394012330 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 366394012331 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 366394012332 putative active site pocket [active] 366394012333 dimerization interface [polypeptide binding]; other site 366394012334 putative catalytic residue [active] 366394012335 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 366394012336 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 366394012337 active site 366394012338 metal binding site [ion binding]; metal-binding site 366394012339 Protein of unknown function (DUF3223); Region: DUF3223; pfam11523 366394012340 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 366394012341 Transposase; Region: HTH_Tnp_1; pfam01527 366394012342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 366394012343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394012344 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 366394012345 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 366394012346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 366394012347 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 366394012348 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 366394012349 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 366394012350 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 366394012351 putative active site [active] 366394012352 putative NTP binding site [chemical binding]; other site 366394012353 putative nucleic acid binding site [nucleotide binding]; other site 366394012354 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 366394012355 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 366394012356 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 366394012357 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 366394012358 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 366394012359 active site 366394012360 nucleophile elbow; other site 366394012361 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 366394012362 active site 366394012363 NTP binding site [chemical binding]; other site 366394012364 metal binding triad [ion binding]; metal-binding site 366394012365 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 366394012366 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 366394012367 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 366394012368 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 366394012369 active site 366394012370 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 366394012371 TSCPD domain; Region: TSCPD; pfam12637 366394012372 Uncharacterized conserved protein [Function unknown]; Region: COG1801 366394012373 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 366394012374 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 366394012375 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 366394012376 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 366394012377 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 366394012378 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 366394012379 dimer interface [polypeptide binding]; other site 366394012380 ssDNA binding site [nucleotide binding]; other site 366394012381 tetramer (dimer of dimers) interface [polypeptide binding]; other site 366394012382 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 366394012383 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 366394012384 TPR repeat; Region: TPR_11; pfam13414 366394012385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394012386 TPR motif; other site 366394012387 binding surface 366394012388 Tetratricopeptide repeat; Region: TPR_16; pfam13432 366394012389 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 366394012390 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 366394012391 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394012392 motif II; other site 366394012393 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 366394012394 Sulfatase; Region: Sulfatase; pfam00884 366394012395 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 366394012396 DNA gyrase subunit A; Validated; Region: PRK05560 366394012397 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 366394012398 CAP-like domain; other site 366394012399 active site 366394012400 primary dimer interface [polypeptide binding]; other site 366394012401 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 366394012402 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 366394012403 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 366394012404 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 366394012405 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 366394012406 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 366394012407 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 366394012408 N-acetyl-D-glucosamine binding site [chemical binding]; other site 366394012409 catalytic residue [active] 366394012410 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 366394012411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394012412 Coenzyme A binding pocket [chemical binding]; other site 366394012413 Streptomycin 6-kinase [Defense mechanisms]; Region: StrB; COG3570 366394012414 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 366394012415 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 366394012416 FMN binding site [chemical binding]; other site 366394012417 active site 366394012418 substrate binding site [chemical binding]; other site 366394012419 catalytic residue [active] 366394012420 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394012421 dimerization interface [polypeptide binding]; other site 366394012422 putative DNA binding site [nucleotide binding]; other site 366394012423 putative Zn2+ binding site [ion binding]; other site 366394012424 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394012425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394012426 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 366394012427 putative effector binding pocket; other site 366394012428 dimerization interface [polypeptide binding]; other site 366394012429 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 366394012430 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 366394012431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394012432 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394012433 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394012434 putative DNA binding site [nucleotide binding]; other site 366394012435 putative Zn2+ binding site [ion binding]; other site 366394012436 AsnC family; Region: AsnC_trans_reg; pfam01037 366394012437 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 366394012438 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 366394012439 putative metal binding site; other site 366394012440 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394012441 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 366394012442 putative ADP-binding pocket [chemical binding]; other site 366394012443 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394012444 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 366394012445 putative ADP-binding pocket [chemical binding]; other site 366394012446 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 366394012447 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 366394012448 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 366394012449 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 366394012450 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 366394012451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394012452 Major Facilitator Superfamily; Region: MFS_1; pfam07690 366394012453 putative substrate translocation pore; other site 366394012454 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 366394012455 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 366394012456 ATP-grasp domain; Region: ATP-grasp_4; cl17255 366394012457 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 366394012458 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 366394012459 ATP-grasp domain; Region: ATP-grasp_4; cl17255 366394012460 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 366394012461 IMP binding site; other site 366394012462 dimer interface [polypeptide binding]; other site 366394012463 partial ornithine binding site; other site 366394012464 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 366394012465 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 366394012466 putative NAD(P) binding site [chemical binding]; other site 366394012467 catalytic Zn binding site [ion binding]; other site 366394012468 Predicted metalloprotease [General function prediction only]; Region: COG2321 366394012469 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 366394012470 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394012471 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394012472 active site 366394012473 catalytic tetrad [active] 366394012474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394012475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394012476 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 366394012477 putative effector binding pocket; other site 366394012478 putative dimerization interface [polypeptide binding]; other site 366394012479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394012480 Major Facilitator Superfamily; Region: MFS_1; pfam07690 366394012481 putative substrate translocation pore; other site 366394012482 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 366394012483 putative efflux protein, MATE family; Region: matE; TIGR00797 366394012484 cation binding site [ion binding]; other site 366394012485 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 366394012486 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 366394012487 active site 366394012488 (T/H)XGH motif; other site 366394012489 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 366394012490 active site 366394012491 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 366394012492 active site 366394012493 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 366394012494 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 366394012495 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 366394012496 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 366394012497 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 366394012498 classical (c) SDRs; Region: SDR_c; cd05233 366394012499 NAD(P) binding site [chemical binding]; other site 366394012500 active site 366394012501 SEC-C motif; Region: SEC-C; pfam02810 366394012502 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 366394012503 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 366394012504 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 366394012505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 366394012506 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394012507 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394012508 classical (c) SDRs; Region: SDR_c; cd05233 366394012509 NAD(P) binding site [chemical binding]; other site 366394012510 active site 366394012511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394012512 Major Facilitator Superfamily; Region: MFS_1; pfam07690 366394012513 putative substrate translocation pore; other site 366394012514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394012515 DNA binding site [nucleotide binding] 366394012516 Predicted integral membrane protein [Function unknown]; Region: COG5616 366394012517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394012518 TPR motif; other site 366394012519 binding surface 366394012520 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394012521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 366394012522 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 366394012523 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 366394012524 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 366394012525 ring oligomerisation interface [polypeptide binding]; other site 366394012526 ATP/Mg binding site [chemical binding]; other site 366394012527 stacking interactions; other site 366394012528 hinge regions; other site 366394012529 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 366394012530 oligomerisation interface [polypeptide binding]; other site 366394012531 mobile loop; other site 366394012532 roof hairpin; other site 366394012533 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 366394012534 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 366394012535 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 366394012536 FMN binding site [chemical binding]; other site 366394012537 active site 366394012538 homodimer interface [polypeptide binding]; other site 366394012539 putative catalytic residue [active] 366394012540 4Fe-4S cluster binding site [ion binding]; other site 366394012541 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 366394012542 Helix-turn-helix domain; Region: HTH_28; pfam13518 366394012543 Winged helix-turn helix; Region: HTH_29; pfam13551 366394012544 Homeodomain-like domain; Region: HTH_32; pfam13565 366394012545 Integrase core domain; Region: rve; pfam00665 366394012546 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 366394012547 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 366394012548 DNA-binding interface [nucleotide binding]; DNA binding site 366394012549 Homeodomain-like domain; Region: HTH_32; pfam13565 366394012550 Integrase core domain; Region: rve; pfam00665 366394012551 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 366394012552 putative hydrolase; Provisional; Region: PRK02113 366394012553 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 366394012554 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 366394012555 active site 366394012556 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 366394012557 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 366394012558 active site 366394012559 HIGH motif; other site 366394012560 KMSKS motif; other site 366394012561 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 366394012562 tRNA binding surface [nucleotide binding]; other site 366394012563 anticodon binding site; other site 366394012564 DNA polymerase III subunit delta'; Validated; Region: PRK09112 366394012565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 366394012566 DNA polymerase III subunit delta'; Validated; Region: PRK08485 366394012567 Peptidase family M23; Region: Peptidase_M23; pfam01551 366394012568 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 366394012569 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 366394012570 TMP-binding site; other site 366394012571 ATP-binding site [chemical binding]; other site 366394012572 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 366394012573 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 366394012574 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 366394012575 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 366394012576 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 366394012577 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394012578 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394012579 non-specific DNA binding site [nucleotide binding]; other site 366394012580 salt bridge; other site 366394012581 sequence-specific DNA binding site [nucleotide binding]; other site 366394012582 Sulfatase; Region: Sulfatase; cl17466 366394012583 Helix-turn-helix domain; Region: HTH_17; pfam12728 366394012584 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 366394012585 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 366394012586 active site 366394012587 DNA binding site [nucleotide binding] 366394012588 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 366394012589 DNA binding site [nucleotide binding] 366394012590 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 366394012591 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 366394012592 catalytic residue [active] 366394012593 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 366394012594 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394012595 HNH endonuclease; Region: HNH_3; pfam13392 366394012596 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 366394012597 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 366394012598 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 366394012599 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 366394012600 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 366394012601 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 366394012602 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 366394012603 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 366394012604 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 366394012605 oligomerization interface [polypeptide binding]; other site 366394012606 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 366394012607 Phage capsid family; Region: Phage_capsid; pfam05065 366394012608 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 366394012609 Phage portal protein; Region: Phage_portal; pfam04860 366394012610 Phage-related protein [Function unknown]; Region: COG4695 366394012611 Phage Terminase; Region: Terminase_1; pfam03354 366394012612 Phage terminase, small subunit; Region: Terminase_4; pfam05119 366394012613 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 366394012614 active site 366394012615 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 366394012616 polymerase nucleotide-binding site; other site 366394012617 DNA-binding residues [nucleotide binding]; DNA binding site 366394012618 nucleotide binding site [chemical binding]; other site 366394012619 primase nucleotide-binding site [nucleotide binding]; other site 366394012620 integrase; Provisional; Region: PRK09692 366394012621 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 366394012622 active site 366394012623 Int/Topo IB signature motif; other site 366394012624 YCII-related domain; Region: YCII; cl00999 366394012625 YfzA-like protein; Region: YfzA; pfam14118 366394012626 LexA repressor; Validated; Region: PRK00215 366394012627 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 366394012628 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 366394012629 Catalytic site [active] 366394012630 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 366394012631 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 366394012632 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 366394012633 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 366394012634 short chain dehydrogenase; Provisional; Region: PRK07024 366394012635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394012636 NAD(P) binding site [chemical binding]; other site 366394012637 active site 366394012638 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 366394012639 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 366394012640 dimer interface [polypeptide binding]; other site 366394012641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394012642 catalytic residue [active] 366394012643 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 366394012644 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 366394012645 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 366394012646 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 366394012647 active site residue [active] 366394012648 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 366394012649 active site residue [active] 366394012650 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 366394012651 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 366394012652 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 366394012653 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 366394012654 hexamer interface [polypeptide binding]; other site 366394012655 ligand binding site [chemical binding]; other site 366394012656 putative active site [active] 366394012657 NAD(P) binding site [chemical binding]; other site 366394012658 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394012659 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394012660 putative DNA binding site [nucleotide binding]; other site 366394012661 putative Zn2+ binding site [ion binding]; other site 366394012662 AsnC family; Region: AsnC_trans_reg; pfam01037 366394012663 Uncharacterized conserved protein [Function unknown]; Region: COG5453 366394012664 threonine dehydratase; Validated; Region: PRK08639 366394012665 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 366394012666 tetramer interface [polypeptide binding]; other site 366394012667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394012668 catalytic residue [active] 366394012669 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 366394012670 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 366394012671 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 366394012672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 366394012673 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 366394012674 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 366394012675 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 366394012676 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 366394012677 putative MPT binding site; other site 366394012678 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 366394012679 active site 366394012680 Uncharacterized conserved protein [Function unknown]; Region: COG0062 366394012681 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 366394012682 putative substrate binding site [chemical binding]; other site 366394012683 putative ATP binding site [chemical binding]; other site 366394012684 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 366394012685 Nitrogen regulatory protein P-II; Region: P-II; smart00938 366394012686 glutamine synthetase; Provisional; Region: glnA; PRK09469 366394012687 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 366394012688 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 366394012689 Uncharacterized conserved protein [Function unknown]; Region: COG3785 366394012690 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 366394012691 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 366394012692 Walker A/P-loop; other site 366394012693 ATP binding site [chemical binding]; other site 366394012694 Q-loop/lid; other site 366394012695 ABC transporter signature motif; other site 366394012696 Walker B; other site 366394012697 D-loop; other site 366394012698 H-loop/switch region; other site 366394012699 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 366394012700 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 366394012701 ABC-ATPase subunit interface; other site 366394012702 dimer interface [polypeptide binding]; other site 366394012703 putative PBP binding regions; other site 366394012704 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 366394012705 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 366394012706 ABC-ATPase subunit interface; other site 366394012707 dimer interface [polypeptide binding]; other site 366394012708 putative PBP binding regions; other site 366394012709 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 366394012710 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 366394012711 intersubunit interface [polypeptide binding]; other site 366394012712 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 366394012713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394012714 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394012715 dimerization interface [polypeptide binding]; other site 366394012716 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 366394012717 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 366394012718 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 366394012719 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 366394012720 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 366394012721 catalytic residues [active] 366394012722 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 366394012723 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 366394012724 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 366394012725 ATP binding site [chemical binding]; other site 366394012726 putative Mg++ binding site [ion binding]; other site 366394012727 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 366394012728 nucleotide binding region [chemical binding]; other site 366394012729 ATP-binding site [chemical binding]; other site 366394012730 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 366394012731 Uncharacterized conserved protein [Function unknown]; Region: COG2938 366394012732 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 366394012733 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 366394012734 generic binding surface II; other site 366394012735 ssDNA binding site; other site 366394012736 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 366394012737 ATP binding site [chemical binding]; other site 366394012738 putative Mg++ binding site [ion binding]; other site 366394012739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 366394012740 nucleotide binding region [chemical binding]; other site 366394012741 ATP-binding site [chemical binding]; other site 366394012742 Uncharacterized conserved protein [Function unknown]; Region: COG2928 366394012743 putative acetyltransferase; Provisional; Region: PRK03624 366394012744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394012745 Coenzyme A binding pocket [chemical binding]; other site 366394012746 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 366394012747 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 366394012748 glutaminase active site [active] 366394012749 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 366394012750 dimer interface [polypeptide binding]; other site 366394012751 active site 366394012752 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 366394012753 dimer interface [polypeptide binding]; other site 366394012754 active site 366394012755 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 366394012756 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 366394012757 Substrate binding site; other site 366394012758 Mg++ binding site; other site 366394012759 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 366394012760 active site 366394012761 substrate binding site [chemical binding]; other site 366394012762 CoA binding site [chemical binding]; other site 366394012763 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 366394012764 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 366394012765 PhoU domain; Region: PhoU; pfam01895 366394012766 PhoU domain; Region: PhoU; pfam01895 366394012767 SurA N-terminal domain; Region: SurA_N_3; cl07813 366394012768 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 366394012769 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 366394012770 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 366394012771 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 366394012772 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 366394012773 active site 366394012774 ribulose/triose binding site [chemical binding]; other site 366394012775 phosphate binding site [ion binding]; other site 366394012776 substrate (anthranilate) binding pocket [chemical binding]; other site 366394012777 product (indole) binding pocket [chemical binding]; other site 366394012778 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 366394012779 trimer interface [polypeptide binding]; other site 366394012780 dimer interface [polypeptide binding]; other site 366394012781 putative active site [active] 366394012782 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 366394012783 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 366394012784 dimer interface [polypeptide binding]; other site 366394012785 putative functional site; other site 366394012786 putative MPT binding site; other site 366394012787 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 366394012788 Domain of unknown function DUF21; Region: DUF21; pfam01595 366394012789 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 366394012790 Transporter associated domain; Region: CorC_HlyC; smart01091 366394012791 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394012792 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394012793 DNA-binding site [nucleotide binding]; DNA binding site 366394012794 FCD domain; Region: FCD; pfam07729 366394012795 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 366394012796 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 366394012797 putative ligand binding site [chemical binding]; other site 366394012798 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394012799 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 366394012800 TM-ABC transporter signature motif; other site 366394012801 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394012802 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 366394012803 TM-ABC transporter signature motif; other site 366394012804 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 366394012805 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394012806 Walker A/P-loop; other site 366394012807 ATP binding site [chemical binding]; other site 366394012808 Q-loop/lid; other site 366394012809 ABC transporter signature motif; other site 366394012810 Walker B; other site 366394012811 D-loop; other site 366394012812 H-loop/switch region; other site 366394012813 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394012814 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 366394012815 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 366394012816 NADP binding site [chemical binding]; other site 366394012817 dimer interface [polypeptide binding]; other site 366394012818 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 366394012819 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 366394012820 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 366394012821 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 366394012822 Predicted permeases [General function prediction only]; Region: COG0679 366394012823 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 366394012824 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 366394012825 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 366394012826 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 366394012827 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 366394012828 putative DNA binding site [nucleotide binding]; other site 366394012829 putative homodimer interface [polypeptide binding]; other site 366394012830 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 366394012831 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 366394012832 putative DNA binding site [nucleotide binding]; other site 366394012833 putative homodimer interface [polypeptide binding]; other site 366394012834 Methyltransferase domain; Region: Methyltransf_31; pfam13847 366394012835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394012836 S-adenosylmethionine binding site [chemical binding]; other site 366394012837 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 366394012838 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 366394012839 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 366394012840 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 366394012841 conserved cys residue [active] 366394012842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394012843 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 366394012844 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394012845 classical (c) SDRs; Region: SDR_c; cd05233 366394012846 NAD(P) binding site [chemical binding]; other site 366394012847 active site 366394012848 acyl-CoA synthetase; Validated; Region: PRK07470 366394012849 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 366394012850 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 366394012851 acyl-activating enzyme (AAE) consensus motif; other site 366394012852 acyl-activating enzyme (AAE) consensus motif; other site 366394012853 putative AMP binding site [chemical binding]; other site 366394012854 putative active site [active] 366394012855 putative CoA binding site [chemical binding]; other site 366394012856 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 366394012857 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 366394012858 active site 366394012859 Transcriptional regulator [Transcription]; Region: IclR; COG1414 366394012860 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 366394012861 Bacterial transcriptional regulator; Region: IclR; pfam01614 366394012862 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 366394012863 classical (c) SDRs; Region: SDR_c; cd05233 366394012864 NAD(P) binding site [chemical binding]; other site 366394012865 active site 366394012866 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 366394012867 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 366394012868 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 366394012869 DctM-like transporters; Region: DctM; pfam06808 366394012870 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 366394012871 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 366394012872 Uncharacterized conserved protein [Function unknown]; Region: COG1430 366394012873 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 366394012874 DNA-binding site [nucleotide binding]; DNA binding site 366394012875 RNA-binding motif; other site 366394012876 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 366394012877 DNA-binding site [nucleotide binding]; DNA binding site 366394012878 RNA-binding motif; other site 366394012879 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394012880 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 366394012881 dimer interface [polypeptide binding]; other site 366394012882 active site 366394012883 metal binding site [ion binding]; metal-binding site 366394012884 glutathione binding site [chemical binding]; other site 366394012885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 366394012886 Peptidase M15; Region: Peptidase_M15_3; cl01194 366394012887 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 366394012888 DHH family; Region: DHH; pfam01368 366394012889 DHHA1 domain; Region: DHHA1; pfam02272 366394012890 homoserine dehydrogenase; Provisional; Region: PRK06349 366394012891 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 366394012892 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 366394012893 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 366394012894 aminotransferase; Validated; Region: PRK09148 366394012895 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394012896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394012897 homodimer interface [polypeptide binding]; other site 366394012898 catalytic residue [active] 366394012899 Short C-terminal domain; Region: SHOCT; pfam09851 366394012900 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 366394012901 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 366394012902 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 366394012903 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 366394012904 active site 366394012905 hypothetical protein; Reviewed; Region: PRK00024 366394012906 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 366394012907 MPN+ (JAMM) motif; other site 366394012908 Zinc-binding site [ion binding]; other site 366394012909 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 366394012910 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 366394012911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394012912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394012913 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 366394012914 substrate binding pocket [chemical binding]; other site 366394012915 dimerization interface [polypeptide binding]; other site 366394012916 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 366394012917 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 366394012918 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394012919 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 366394012920 FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997 366394012921 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 366394012922 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 366394012923 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 366394012924 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 366394012925 catalytic residue [active] 366394012926 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 366394012927 FeS assembly protein SufD; Region: sufD; TIGR01981 366394012928 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 366394012929 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 366394012930 Walker A/P-loop; other site 366394012931 ATP binding site [chemical binding]; other site 366394012932 Q-loop/lid; other site 366394012933 ABC transporter signature motif; other site 366394012934 Walker B; other site 366394012935 D-loop; other site 366394012936 H-loop/switch region; other site 366394012937 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 366394012938 putative ABC transporter; Region: ycf24; CHL00085 366394012939 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 366394012940 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 366394012941 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 366394012942 catalytic residue [active] 366394012943 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 366394012944 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394012945 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394012946 metal binding site [ion binding]; metal-binding site 366394012947 active site 366394012948 I-site; other site 366394012949 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 366394012950 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 366394012951 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 366394012952 active site 366394012953 HIGH motif; other site 366394012954 dimer interface [polypeptide binding]; other site 366394012955 KMSKS motif; other site 366394012956 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 366394012957 RNA binding surface [nucleotide binding]; other site 366394012958 Protein of unknown function; Region: DUF3971; pfam13116 366394012959 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 366394012960 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 366394012961 catalytic triad [active] 366394012962 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 366394012963 dinuclear metal binding motif [ion binding]; other site 366394012964 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 366394012965 Peptidase family M23; Region: Peptidase_M23; pfam01551 366394012966 helicase 45; Provisional; Region: PTZ00424 366394012967 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 366394012968 ATP binding site [chemical binding]; other site 366394012969 Mg++ binding site [ion binding]; other site 366394012970 motif III; other site 366394012971 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 366394012972 nucleotide binding region [chemical binding]; other site 366394012973 ATP-binding site [chemical binding]; other site 366394012974 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 366394012975 nudix motif; other site 366394012976 TfoX N-terminal domain; Region: TfoX_N; pfam04993 366394012977 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 366394012978 putative MPT binding site; other site 366394012979 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 366394012980 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 366394012981 Ligand binding site; other site 366394012982 metal-binding site 366394012983 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 366394012984 XdhC Rossmann domain; Region: XdhC_C; pfam13478 366394012985 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 366394012986 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 366394012987 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 366394012988 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 366394012989 metal ion-dependent adhesion site (MIDAS); other site 366394012990 MoxR-like ATPases [General function prediction only]; Region: COG0714 366394012991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394012992 Walker A motif; other site 366394012993 ATP binding site [chemical binding]; other site 366394012994 Walker B motif; other site 366394012995 arginine finger; other site 366394012996 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 366394012997 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 366394012998 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 366394012999 ligand binding site [chemical binding]; other site 366394013000 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 366394013001 putative active site pocket [active] 366394013002 cleavage site 366394013003 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 366394013004 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 366394013005 substrate binding site [chemical binding]; other site 366394013006 hexamer interface [polypeptide binding]; other site 366394013007 metal binding site [ion binding]; metal-binding site 366394013008 Predicted secreted protein (DUF2259); Region: DUF2259; pfam10016 366394013009 adenylosuccinate lyase; Provisional; Region: PRK07492 366394013010 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 366394013011 tetramer interface [polypeptide binding]; other site 366394013012 active site 366394013013 Predicted integral membrane protein [Function unknown]; Region: COG5473 366394013014 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 366394013015 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 366394013016 Uncharacterized conserved protein [Function unknown]; Region: COG5467 366394013017 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 366394013018 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 366394013019 ATP binding site [chemical binding]; other site 366394013020 active site 366394013021 substrate binding site [chemical binding]; other site 366394013022 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 366394013023 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 366394013024 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 366394013025 putative active site [active] 366394013026 catalytic triad [active] 366394013027 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 366394013028 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 366394013029 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394013030 DNA-binding site [nucleotide binding]; DNA binding site 366394013031 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394013032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394013033 homodimer interface [polypeptide binding]; other site 366394013034 catalytic residue [active] 366394013035 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 366394013036 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 366394013037 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 366394013038 dimerization interface [polypeptide binding]; other site 366394013039 ATP binding site [chemical binding]; other site 366394013040 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 366394013041 dimerization interface [polypeptide binding]; other site 366394013042 ATP binding site [chemical binding]; other site 366394013043 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 366394013044 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 366394013045 putative GSH binding site [chemical binding]; other site 366394013046 catalytic residues [active] 366394013047 Major Facilitator Superfamily; Region: MFS_1; pfam07690 366394013048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394013049 putative substrate translocation pore; other site 366394013050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394013051 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 366394013052 putative substrate translocation pore; other site 366394013053 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 366394013054 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 366394013055 active site 366394013056 putative lithium-binding site [ion binding]; other site 366394013057 substrate binding site [chemical binding]; other site 366394013058 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 366394013059 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 366394013060 Ligand Binding Site [chemical binding]; other site 366394013061 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 366394013062 glutaminase; Provisional; Region: PRK00971 366394013063 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 366394013064 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 366394013065 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 366394013066 RNA binding surface [nucleotide binding]; other site 366394013067 Domain of unknown function DUF87; Region: DUF87; pfam01935 366394013068 HerA helicase [Replication, recombination, and repair]; Region: COG0433 366394013069 glutamate racemase; Provisional; Region: PRK00865 366394013070 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 366394013071 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 366394013072 Predicted membrane protein [Function unknown]; Region: COG1289 366394013073 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 366394013074 isocitrate dehydrogenase; Validated; Region: PRK08299 366394013075 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 366394013076 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 366394013077 motif 1; other site 366394013078 active site 366394013079 motif 2; other site 366394013080 motif 3; other site 366394013081 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 366394013082 recombinase A; Provisional; Region: recA; PRK09354 366394013083 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 366394013084 hexamer interface [polypeptide binding]; other site 366394013085 Walker A motif; other site 366394013086 ATP binding site [chemical binding]; other site 366394013087 Walker B motif; other site 366394013088 Uncharacterized enzyme involved in pigment biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IndA; COG2313 366394013089 PAS domain; Region: PAS; smart00091 366394013090 PAS domain; Region: PAS_9; pfam13426 366394013091 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 366394013092 PAS domain; Region: PAS; smart00091 366394013093 putative active site [active] 366394013094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394013095 heme pocket [chemical binding]; other site 366394013096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394013097 dimer interface [polypeptide binding]; other site 366394013098 phosphorylation site [posttranslational modification] 366394013099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394013100 ATP binding site [chemical binding]; other site 366394013101 Mg2+ binding site [ion binding]; other site 366394013102 G-X-G motif; other site 366394013103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394013104 Response regulator receiver domain; Region: Response_reg; pfam00072 366394013105 active site 366394013106 phosphorylation site [posttranslational modification] 366394013107 intermolecular recognition site; other site 366394013108 dimerization interface [polypeptide binding]; other site 366394013109 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 366394013110 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 366394013111 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 366394013112 catalytic core [active] 366394013113 Predicted ATPase [General function prediction only]; Region: COG3106 366394013114 Predicted membrane protein [Function unknown]; Region: COG3768 366394013115 Domain of unknown function (DUF697); Region: DUF697; cl12064 366394013116 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 366394013117 catalytic center binding site [active] 366394013118 ATP binding site [chemical binding]; other site 366394013119 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 366394013120 homooctamer interface [polypeptide binding]; other site 366394013121 active site 366394013122 dihydropteroate synthase; Region: DHPS; TIGR01496 366394013123 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 366394013124 substrate binding pocket [chemical binding]; other site 366394013125 dimer interface [polypeptide binding]; other site 366394013126 inhibitor binding site; inhibition site 366394013127 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661 366394013128 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 366394013129 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394013130 catalytic loop [active] 366394013131 iron binding site [ion binding]; other site 366394013132 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 366394013133 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 366394013134 cytochrome b; Provisional; Region: CYTB; MTH00191 366394013135 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 366394013136 Qi binding site; other site 366394013137 intrachain domain interface; other site 366394013138 interchain domain interface [polypeptide binding]; other site 366394013139 heme bH binding site [chemical binding]; other site 366394013140 heme bL binding site [chemical binding]; other site 366394013141 Qo binding site; other site 366394013142 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 366394013143 interchain domain interface [polypeptide binding]; other site 366394013144 intrachain domain interface; other site 366394013145 Qi binding site; other site 366394013146 Qo binding site; other site 366394013147 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 366394013148 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 366394013149 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 366394013150 [2Fe-2S] cluster binding site [ion binding]; other site 366394013151 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 366394013152 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 366394013153 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 366394013154 Walker A/P-loop; other site 366394013155 ATP binding site [chemical binding]; other site 366394013156 Q-loop/lid; other site 366394013157 ABC transporter signature motif; other site 366394013158 Walker B; other site 366394013159 D-loop; other site 366394013160 H-loop/switch region; other site 366394013161 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 366394013162 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 366394013163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394013164 Walker A/P-loop; other site 366394013165 ATP binding site [chemical binding]; other site 366394013166 Q-loop/lid; other site 366394013167 ABC transporter signature motif; other site 366394013168 Walker B; other site 366394013169 D-loop; other site 366394013170 H-loop/switch region; other site 366394013171 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 366394013172 Predicted flavoprotein [General function prediction only]; Region: COG0431 366394013173 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 366394013174 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 366394013175 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 366394013176 DNA binding residues [nucleotide binding] 366394013177 dimer interface [polypeptide binding]; other site 366394013178 [2Fe-2S] cluster binding site [ion binding]; other site 366394013179 Coproporphyrinogen III oxidase [Coenzyme metabolism]; Region: HemF; COG0408 366394013180 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 366394013181 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 366394013182 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 366394013183 mce related protein; Region: MCE; pfam02470 366394013184 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 366394013185 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 366394013186 Walker A/P-loop; other site 366394013187 ATP binding site [chemical binding]; other site 366394013188 Q-loop/lid; other site 366394013189 ABC transporter signature motif; other site 366394013190 Walker B; other site 366394013191 D-loop; other site 366394013192 H-loop/switch region; other site 366394013193 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 366394013194 Permease; Region: Permease; pfam02405 366394013195 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 366394013196 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 366394013197 active site 366394013198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394013199 putative substrate translocation pore; other site 366394013200 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 366394013201 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 366394013202 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 366394013203 putative active site [active] 366394013204 putative metal binding site [ion binding]; other site 366394013205 malic enzyme; Reviewed; Region: PRK12862 366394013206 Malic enzyme, N-terminal domain; Region: malic; pfam00390 366394013207 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 366394013208 putative NAD(P) binding site [chemical binding]; other site 366394013209 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 366394013210 Autoinducer binding domain; Region: Autoind_bind; pfam03472 366394013211 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394013212 DNA binding residues [nucleotide binding] 366394013213 dimerization interface [polypeptide binding]; other site 366394013214 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 366394013215 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 366394013216 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 366394013217 putative FMN binding site [chemical binding]; other site 366394013218 short chain dehydrogenase; Provisional; Region: PRK06198 366394013219 classical (c) SDRs; Region: SDR_c; cd05233 366394013220 NAD(P) binding site [chemical binding]; other site 366394013221 active site 366394013222 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 366394013223 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 366394013224 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 366394013225 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 366394013226 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 366394013227 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 366394013228 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 366394013229 NAD synthetase; Provisional; Region: PRK13981 366394013230 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 366394013231 multimer interface [polypeptide binding]; other site 366394013232 active site 366394013233 catalytic triad [active] 366394013234 protein interface 1 [polypeptide binding]; other site 366394013235 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 366394013236 homodimer interface [polypeptide binding]; other site 366394013237 NAD binding pocket [chemical binding]; other site 366394013238 ATP binding pocket [chemical binding]; other site 366394013239 Mg binding site [ion binding]; other site 366394013240 active-site loop [active] 366394013241 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 366394013242 Sulfatase; Region: Sulfatase; pfam00884 366394013243 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394013244 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 366394013245 glutathione reductase; Validated; Region: PRK06116 366394013246 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394013247 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 366394013248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 366394013249 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 366394013250 tetramer (dimer of dimers) interface [polypeptide binding]; other site 366394013251 active site 366394013252 dimer interface [polypeptide binding]; other site 366394013253 phosphoglycolate phosphatase; Provisional; Region: PRK13222 366394013254 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394013255 motif II; other site 366394013256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 366394013257 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394013258 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394013259 fumarate hydratase; Reviewed; Region: fumC; PRK00485 366394013260 Class II fumarases; Region: Fumarase_classII; cd01362 366394013261 active site 366394013262 tetramer interface [polypeptide binding]; other site 366394013263 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 366394013264 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 366394013265 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 366394013266 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 366394013267 Transcriptional regulators [Transcription]; Region: MarR; COG1846 366394013268 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394013269 dimerization interface [polypeptide binding]; other site 366394013270 putative Zn2+ binding site [ion binding]; other site 366394013271 putative DNA binding site [nucleotide binding]; other site 366394013272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 366394013273 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 366394013274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 366394013275 FeS/SAM binding site; other site 366394013276 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 366394013277 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 366394013278 EamA-like transporter family; Region: EamA; pfam00892 366394013279 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 366394013280 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 366394013281 GTP binding site; other site 366394013282 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 366394013283 Walker A motif; other site 366394013284 Sel1-like repeats; Region: SEL1; smart00671 366394013285 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 366394013286 Sel1-like repeats; Region: SEL1; smart00671 366394013287 Sel1-like repeats; Region: SEL1; smart00671 366394013288 Sel1-like repeats; Region: SEL1; smart00671 366394013289 Sel1-like repeats; Region: SEL1; smart00671 366394013290 Sel1-like repeats; Region: SEL1; smart00671 366394013291 Sel1-like repeats; Region: SEL1; smart00671 366394013292 Sel1-like repeats; Region: SEL1; smart00671 366394013293 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 366394013294 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 366394013295 ligand binding site [chemical binding]; other site 366394013296 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 366394013297 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394013298 substrate binding pocket [chemical binding]; other site 366394013299 membrane-bound complex binding site; other site 366394013300 hinge residues; other site 366394013301 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 366394013302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394013303 dimer interface [polypeptide binding]; other site 366394013304 conserved gate region; other site 366394013305 putative PBP binding loops; other site 366394013306 ABC-ATPase subunit interface; other site 366394013307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394013308 dimer interface [polypeptide binding]; other site 366394013309 conserved gate region; other site 366394013310 putative PBP binding loops; other site 366394013311 ABC-ATPase subunit interface; other site 366394013312 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 366394013313 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 366394013314 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 366394013315 putative NAD(P) binding site [chemical binding]; other site 366394013316 putative active site [active] 366394013317 Predicted integral membrane protein [Function unknown]; Region: COG5530 366394013318 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 366394013319 Tetratricopeptide repeat; Region: TPR_1; pfam00515 366394013320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394013321 S-adenosylmethionine binding site [chemical binding]; other site 366394013322 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 366394013323 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 366394013324 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 366394013325 A new structural DNA glycosylase; Region: AlkD_like; cd06561 366394013326 active site 366394013327 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394013328 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394013329 putative DNA binding site [nucleotide binding]; other site 366394013330 putative Zn2+ binding site [ion binding]; other site 366394013331 AsnC family; Region: AsnC_trans_reg; pfam01037 366394013332 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 366394013333 putative uracil binding site [chemical binding]; other site 366394013334 putative active site [active] 366394013335 Staphylococcal nuclease homologues; Region: SNc; smart00318 366394013336 Catalytic site; other site 366394013337 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 366394013338 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394013339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394013340 dimer interface [polypeptide binding]; other site 366394013341 phosphorylation site [posttranslational modification] 366394013342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394013343 ATP binding site [chemical binding]; other site 366394013344 Mg2+ binding site [ion binding]; other site 366394013345 G-X-G motif; other site 366394013346 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394013347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394013348 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394013349 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 366394013350 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 366394013351 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 366394013352 putative dimer interface [polypeptide binding]; other site 366394013353 active site pocket [active] 366394013354 putative cataytic base [active] 366394013355 cobalamin synthase; Reviewed; Region: cobS; PRK00235 366394013356 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 366394013357 Predicted aspartyl protease [General function prediction only]; Region: COG3577 366394013358 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 366394013359 catalytic motif [active] 366394013360 Catalytic residue [active] 366394013361 ABC-2 type transporter; Region: ABC2_membrane; cl17235 366394013362 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 366394013363 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 366394013364 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 366394013365 Walker A/P-loop; other site 366394013366 ATP binding site [chemical binding]; other site 366394013367 Q-loop/lid; other site 366394013368 ABC transporter signature motif; other site 366394013369 Walker B; other site 366394013370 D-loop; other site 366394013371 H-loop/switch region; other site 366394013372 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394013373 dimerization interface [polypeptide binding]; other site 366394013374 putative DNA binding site [nucleotide binding]; other site 366394013375 putative Zn2+ binding site [ion binding]; other site 366394013376 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 366394013377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 366394013378 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 366394013379 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097 366394013380 Cache domain; Region: Cache_2; pfam08269 366394013381 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 366394013382 dimerization interface [polypeptide binding]; other site 366394013383 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 366394013384 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 366394013385 dimer interface [polypeptide binding]; other site 366394013386 putative CheW interface [polypeptide binding]; other site 366394013387 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 366394013388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169 366394013389 excinuclease ABC subunit B; Provisional; Region: PRK05298 366394013390 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 366394013391 ATP binding site [chemical binding]; other site 366394013392 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 366394013393 nucleotide binding region [chemical binding]; other site 366394013394 ATP-binding site [chemical binding]; other site 366394013395 Ultra-violet resistance protein B; Region: UvrB; pfam12344 366394013396 UvrB/uvrC motif; Region: UVR; pfam02151 366394013397 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 366394013398 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 366394013399 HSP70 interaction site [polypeptide binding]; other site 366394013400 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 366394013401 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 366394013402 DNA-binding site [nucleotide binding]; DNA binding site 366394013403 RNA-binding motif; other site 366394013404 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 366394013405 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 366394013406 FMN binding site [chemical binding]; other site 366394013407 active site 366394013408 catalytic residues [active] 366394013409 substrate binding site [chemical binding]; other site 366394013410 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 366394013411 active site 366394013412 DNA binding site [nucleotide binding] 366394013413 Int/Topo IB signature motif; other site 366394013414 Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; Region: Bromodomain; cl02556 366394013415 acetyllysine binding site; other site 366394013416 Predicted nucleotide kinase (related to CMP and AMP kinases) [Nucleotide transport and metabolism]; Region: COG1936 366394013417 AAA domain; Region: AAA_17; pfam13207 366394013418 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 366394013419 active site 366394013420 catalytic residues [active] 366394013421 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 366394013422 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 366394013423 catalytic residues [active] 366394013424 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 366394013425 catalytic residues [active] 366394013426 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 366394013427 Protein export membrane protein; Region: SecD_SecF; cl14618 366394013428 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 366394013429 catalytic residue [active] 366394013430 autotransport protein MisL; Provisional; Region: PRK15313 366394013431 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 366394013432 outer membrane protease; Reviewed; Region: PRK10993 366394013433 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 366394013434 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 366394013435 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 366394013436 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 366394013437 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 366394013438 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 366394013439 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 366394013440 tandem repeat interface [polypeptide binding]; other site 366394013441 oligomer interface [polypeptide binding]; other site 366394013442 active site residues [active] 366394013443 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 366394013444 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 366394013445 gpW; Region: gpW; pfam02831 366394013446 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 366394013447 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 366394013448 Transcription antiterminator [Transcription]; Region: NusG; COG0250 366394013449 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 366394013450 heterodimer interface [polypeptide binding]; other site 366394013451 homodimer interface [polypeptide binding]; other site 366394013452 Helix-turn-helix domain; Region: HTH_36; pfam13730 366394013453 Protein of unknown function (DUF982); Region: DUF982; pfam06169 366394013454 MT-A70; Region: MT-A70; cl01947 366394013455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394013456 non-specific DNA binding site [nucleotide binding]; other site 366394013457 salt bridge; other site 366394013458 sequence-specific DNA binding site [nucleotide binding]; other site 366394013459 Predicted transcriptional regulator [Transcription]; Region: COG2932 366394013460 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 366394013461 Catalytic site [active] 366394013462 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 366394013463 HNH endonuclease; Region: HNH_3; pfam13392 366394013464 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 366394013465 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 366394013466 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 366394013467 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 366394013468 catalytic site [active] 366394013469 Sterile alpha motif; Region: SAM; smart00454 366394013470 SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487 366394013471 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394013472 cyclase homology domain; Region: CHD; cd07302 366394013473 nucleotidyl binding site; other site 366394013474 metal binding site [ion binding]; metal-binding site 366394013475 dimer interface [polypeptide binding]; other site 366394013476 AAA ATPase domain; Region: AAA_16; pfam13191 366394013477 Predicted ATPase [General function prediction only]; Region: COG3903 366394013478 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 366394013479 Protein of unknown function (DUF982); Region: DUF982; pfam06169 366394013480 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 366394013481 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 366394013482 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 366394013483 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 366394013484 trimer interface [polypeptide binding]; other site 366394013485 putative metal binding site [ion binding]; other site 366394013486 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 366394013487 metal binding site 2 [ion binding]; metal-binding site 366394013488 putative DNA binding helix; other site 366394013489 metal binding site 1 [ion binding]; metal-binding site 366394013490 dimer interface [polypeptide binding]; other site 366394013491 structural Zn2+ binding site [ion binding]; other site 366394013492 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 366394013493 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 366394013494 ABC-ATPase subunit interface; other site 366394013495 dimer interface [polypeptide binding]; other site 366394013496 putative PBP binding regions; other site 366394013497 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 366394013498 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 366394013499 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 366394013500 intersubunit interface [polypeptide binding]; other site 366394013501 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 366394013502 metal binding site [ion binding]; metal-binding site 366394013503 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 366394013504 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394013505 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394013506 Walker A/P-loop; other site 366394013507 ATP binding site [chemical binding]; other site 366394013508 Q-loop/lid; other site 366394013509 ABC transporter signature motif; other site 366394013510 Walker B; other site 366394013511 D-loop; other site 366394013512 H-loop/switch region; other site 366394013513 TOBE domain; Region: TOBE_2; pfam08402 366394013514 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394013515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394013516 dimer interface [polypeptide binding]; other site 366394013517 conserved gate region; other site 366394013518 putative PBP binding loops; other site 366394013519 ABC-ATPase subunit interface; other site 366394013520 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 366394013521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394013522 dimer interface [polypeptide binding]; other site 366394013523 ABC-ATPase subunit interface; other site 366394013524 putative PBP binding loops; other site 366394013525 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394013526 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394013527 transposase; Provisional; Region: PRK06526 366394013528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394013529 Walker A motif; other site 366394013530 ATP binding site [chemical binding]; other site 366394013531 Walker B motif; other site 366394013532 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 366394013533 Integrase core domain; Region: rve; pfam00665 366394013534 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394013535 classical (c) SDRs; Region: SDR_c; cd05233 366394013536 NAD(P) binding site [chemical binding]; other site 366394013537 active site 366394013538 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394013539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394013540 DNA-binding site [nucleotide binding]; DNA binding site 366394013541 FCD domain; Region: FCD; pfam07729 366394013542 Predicted integral membrane protein [Function unknown]; Region: COG5455 366394013543 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 366394013544 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 366394013545 inhibitor binding site; inhibition site 366394013546 active site 366394013547 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 366394013548 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 366394013549 DctM-like transporters; Region: DctM; pfam06808 366394013550 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 366394013551 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 366394013552 histidinol dehydrogenase; Region: hisD; TIGR00069 366394013553 NAD binding site [chemical binding]; other site 366394013554 dimerization interface [polypeptide binding]; other site 366394013555 product binding site; other site 366394013556 substrate binding site [chemical binding]; other site 366394013557 zinc binding site [ion binding]; other site 366394013558 catalytic residues [active] 366394013559 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394013560 sequence-specific DNA binding site [nucleotide binding]; other site 366394013561 salt bridge; other site 366394013562 Cupin domain; Region: Cupin_2; pfam07883 366394013563 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 366394013564 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394013565 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394013566 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 366394013567 Walker A/P-loop; other site 366394013568 ATP binding site [chemical binding]; other site 366394013569 Q-loop/lid; other site 366394013570 ABC transporter signature motif; other site 366394013571 Walker B; other site 366394013572 D-loop; other site 366394013573 H-loop/switch region; other site 366394013574 TOBE domain; Region: TOBE_2; pfam08402 366394013575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394013576 dimer interface [polypeptide binding]; other site 366394013577 conserved gate region; other site 366394013578 putative PBP binding loops; other site 366394013579 ABC-ATPase subunit interface; other site 366394013580 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394013581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394013582 dimer interface [polypeptide binding]; other site 366394013583 conserved gate region; other site 366394013584 putative PBP binding loops; other site 366394013585 ABC-ATPase subunit interface; other site 366394013586 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 366394013587 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 366394013588 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394013589 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394013590 active site 366394013591 catalytic tetrad [active] 366394013592 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394013593 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394013594 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 366394013595 Acylphosphatase; Region: Acylphosphatase; cl00551 366394013596 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 366394013597 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 366394013598 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 366394013599 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 366394013600 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394013601 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394013602 Walker A/P-loop; other site 366394013603 ATP binding site [chemical binding]; other site 366394013604 Q-loop/lid; other site 366394013605 ABC transporter signature motif; other site 366394013606 Walker B; other site 366394013607 D-loop; other site 366394013608 H-loop/switch region; other site 366394013609 TOBE domain; Region: TOBE_2; pfam08402 366394013610 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394013611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394013612 dimer interface [polypeptide binding]; other site 366394013613 conserved gate region; other site 366394013614 putative PBP binding loops; other site 366394013615 ABC-ATPase subunit interface; other site 366394013616 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 366394013617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394013618 dimer interface [polypeptide binding]; other site 366394013619 conserved gate region; other site 366394013620 putative PBP binding loops; other site 366394013621 ABC-ATPase subunit interface; other site 366394013622 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394013623 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394013624 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394013625 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394013626 DNA binding site [nucleotide binding] 366394013627 domain linker motif; other site 366394013628 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 366394013629 ligand binding site [chemical binding]; other site 366394013630 Frequency clock protein; Region: FRQ; pfam09421 366394013631 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 366394013632 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 366394013633 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 366394013634 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 366394013635 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394013636 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 366394013637 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 366394013638 putative acyl-acceptor binding pocket; other site 366394013639 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 366394013640 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 366394013641 putative NAD(P) binding site [chemical binding]; other site 366394013642 structural Zn binding site [ion binding]; other site 366394013643 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 366394013644 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 366394013645 dimer interface [polypeptide binding]; other site 366394013646 active site 366394013647 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 366394013648 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 366394013649 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 366394013650 active site 366394013651 active site 366394013652 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 366394013653 active site 2 [active] 366394013654 active site 1 [active] 366394013655 acyl carrier protein; Provisional; Region: PRK06508 366394013656 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 366394013657 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 366394013658 ligand binding site [chemical binding]; other site 366394013659 flexible hinge region; other site 366394013660 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 366394013661 putative switch regulator; other site 366394013662 non-specific DNA interactions [nucleotide binding]; other site 366394013663 DNA binding site [nucleotide binding] 366394013664 sequence specific DNA binding site [nucleotide binding]; other site 366394013665 putative cAMP binding site [chemical binding]; other site 366394013666 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 366394013667 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 366394013668 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394013669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394013670 homodimer interface [polypeptide binding]; other site 366394013671 catalytic residue [active] 366394013672 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 366394013673 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 366394013674 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 366394013675 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 366394013676 active site 366394013677 SAM binding site [chemical binding]; other site 366394013678 homodimer interface [polypeptide binding]; other site 366394013679 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 366394013680 hypothetical protein; Provisional; Region: PRK10621 366394013681 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 366394013682 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 366394013683 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394013684 Walker A/P-loop; other site 366394013685 ATP binding site [chemical binding]; other site 366394013686 Q-loop/lid; other site 366394013687 ABC transporter signature motif; other site 366394013688 Walker B; other site 366394013689 D-loop; other site 366394013690 H-loop/switch region; other site 366394013691 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394013692 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394013693 Walker A/P-loop; other site 366394013694 ATP binding site [chemical binding]; other site 366394013695 Q-loop/lid; other site 366394013696 ABC transporter signature motif; other site 366394013697 Walker B; other site 366394013698 D-loop; other site 366394013699 H-loop/switch region; other site 366394013700 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 366394013701 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 366394013702 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394013703 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 366394013704 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394013705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394013706 dimer interface [polypeptide binding]; other site 366394013707 conserved gate region; other site 366394013708 putative PBP binding loops; other site 366394013709 ABC-ATPase subunit interface; other site 366394013710 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 366394013711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394013712 dimer interface [polypeptide binding]; other site 366394013713 conserved gate region; other site 366394013714 putative PBP binding loops; other site 366394013715 ABC-ATPase subunit interface; other site 366394013716 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 366394013717 ANTAR domain; Region: ANTAR; pfam03861 366394013718 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 366394013719 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 366394013720 ligand binding site [chemical binding]; other site 366394013721 regulator interaction site; other site 366394013722 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 366394013723 Predicted membrane protein [Function unknown]; Region: COG2510 366394013724 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 366394013725 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 366394013726 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 366394013727 homodimer interface [polypeptide binding]; other site 366394013728 Walker A motif; other site 366394013729 ATP binding site [chemical binding]; other site 366394013730 hydroxycobalamin binding site [chemical binding]; other site 366394013731 Walker B motif; other site 366394013732 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 366394013733 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 366394013734 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 366394013735 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 366394013736 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 366394013737 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 366394013738 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 366394013739 homotrimer interface [polypeptide binding]; other site 366394013740 Walker A motif; other site 366394013741 GTP binding site [chemical binding]; other site 366394013742 Walker B motif; other site 366394013743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 366394013744 FecR protein; Region: FecR; pfam04773 366394013745 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 366394013746 CHASE2 domain; Region: CHASE2; pfam05226 366394013747 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394013748 cyclase homology domain; Region: CHD; cd07302 366394013749 nucleotidyl binding site; other site 366394013750 metal binding site [ion binding]; metal-binding site 366394013751 dimer interface [polypeptide binding]; other site 366394013752 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 366394013753 cobyric acid synthase; Provisional; Region: PRK00784 366394013754 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 366394013755 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 366394013756 catalytic triad [active] 366394013757 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 366394013758 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 366394013759 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 366394013760 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 366394013761 Walker A/P-loop; other site 366394013762 ATP binding site [chemical binding]; other site 366394013763 Q-loop/lid; other site 366394013764 ABC transporter signature motif; other site 366394013765 Walker B; other site 366394013766 D-loop; other site 366394013767 H-loop/switch region; other site 366394013768 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 366394013769 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 366394013770 active site 1 [active] 366394013771 dimer interface [polypeptide binding]; other site 366394013772 hexamer interface [polypeptide binding]; other site 366394013773 active site 2 [active] 366394013774 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 366394013775 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394013776 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394013777 dimerization interface [polypeptide binding]; other site 366394013778 methionine synthase I; Validated; Region: PRK07534 366394013779 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 366394013780 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 366394013781 Predicted periplasmic protein [Function unknown]; Region: COG3698 366394013782 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 366394013783 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 366394013784 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 366394013785 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 366394013786 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 366394013787 B12 binding site [chemical binding]; other site 366394013788 cobalt ligand [ion binding]; other site 366394013789 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 366394013790 Entericidin EcnA/B family; Region: Entericidin; cl02322 366394013791 BA14K-like protein; Region: BA14K; pfam07886 366394013792 Virulence factor; Region: Virulence_fact; pfam13769 366394013793 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 366394013794 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 366394013795 FAD binding site [chemical binding]; other site 366394013796 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 366394013797 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 366394013798 substrate binding pocket [chemical binding]; other site 366394013799 dimer interface [polypeptide binding]; other site 366394013800 inhibitor binding site; inhibition site 366394013801 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 366394013802 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394013803 catalytic loop [active] 366394013804 iron binding site [ion binding]; other site 366394013805 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 366394013806 AAA domain; Region: AAA_33; pfam13671 366394013807 P-loop motif; other site 366394013808 ATP binding site [chemical binding]; other site 366394013809 Chloramphenicol (Cm) binding site [chemical binding]; other site 366394013810 catalytic residue [active] 366394013811 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394013812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394013813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394013814 dimerization interface [polypeptide binding]; other site 366394013815 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 366394013816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 366394013817 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 366394013818 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 366394013819 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 366394013820 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 366394013821 putative metal binding site [ion binding]; other site 366394013822 putative homodimer interface [polypeptide binding]; other site 366394013823 putative homotetramer interface [polypeptide binding]; other site 366394013824 putative homodimer-homodimer interface [polypeptide binding]; other site 366394013825 putative allosteric switch controlling residues; other site 366394013826 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 366394013827 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 366394013828 conserved cys residue [active] 366394013829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394013830 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 366394013831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394013832 active site 366394013833 phosphorylation site [posttranslational modification] 366394013834 intermolecular recognition site; other site 366394013835 dimerization interface [polypeptide binding]; other site 366394013836 Response regulator receiver domain; Region: Response_reg; pfam00072 366394013837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394013838 active site 366394013839 phosphorylation site [posttranslational modification] 366394013840 intermolecular recognition site; other site 366394013841 dimerization interface [polypeptide binding]; other site 366394013842 RibD C-terminal domain; Region: RibD_C; cl17279 366394013843 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 366394013844 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 366394013845 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 366394013846 Mechanosensitive ion channel; Region: MS_channel; pfam00924 366394013847 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394013848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 366394013849 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 366394013850 transmembrane helices; other site 366394013851 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 366394013852 TrkA-C domain; Region: TrkA_C; pfam02080 366394013853 TrkA-C domain; Region: TrkA_C; pfam02080 366394013854 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 366394013855 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 366394013856 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 366394013857 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 366394013858 catalytic residue [active] 366394013859 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 366394013860 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 366394013861 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 366394013862 trimer interface [polypeptide binding]; other site 366394013863 active site 366394013864 substrate binding site [chemical binding]; other site 366394013865 CoA binding site [chemical binding]; other site 366394013866 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 366394013867 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 366394013868 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 366394013869 putative mechanosensitive channel protein; Provisional; Region: PRK10929 366394013870 Terminase-like family; Region: Terminase_6; pfam03237 366394013871 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 366394013872 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394013873 transposase; Provisional; Region: PRK06526 366394013874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394013875 Walker A motif; other site 366394013876 ATP binding site [chemical binding]; other site 366394013877 Walker B motif; other site 366394013878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 366394013879 Integrase core domain; Region: rve; pfam00665 366394013880 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394013881 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394013882 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394013883 BA14K-like protein; Region: BA14K; pfam07886 366394013884 Bacterial dnaA protein helix-turn-helix domain; Region: Bac_DnaA_C; smart00760 366394013885 DnaA box-binding interface [nucleotide binding]; other site 366394013886 Predicted transcriptional regulator [Transcription]; Region: COG2932 366394013887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394013888 non-specific DNA binding site [nucleotide binding]; other site 366394013889 salt bridge; other site 366394013890 sequence-specific DNA binding site [nucleotide binding]; other site 366394013891 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 366394013892 Catalytic site [active] 366394013893 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 366394013894 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 366394013895 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 366394013896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 366394013897 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 366394013898 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 366394013899 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 366394013900 catalytic residues [active] 366394013901 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 366394013902 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 366394013903 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 366394013904 catalytic residues [active] 366394013905 Predicted chitinase [General function prediction only]; Region: COG3179 366394013906 catalytic residue [active] 366394013907 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394013908 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 366394013909 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 366394013910 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 366394013911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 366394013912 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 366394013913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 366394013914 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 366394013915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567 366394013916 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 366394013917 Phage terminase large subunit; Region: Terminase_3; cl12054 366394013918 Terminase-like family; Region: Terminase_6; pfam03237 366394013919 Uncharacterized conserved protein [Function unknown]; Region: COG5323 366394013920 Terminase small subunit; Region: Terminase_2; cl01513 366394013921 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 366394013922 acyl carrier protein; Provisional; Region: acpP; PRK00982 366394013923 Transcription termination factor nusG; Region: NusG; pfam02357 366394013924 GcrA cell cycle regulator; Region: GcrA; cl11564 366394013925 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 366394013926 Protein of unknown function (DUF982); Region: DUF982; pfam06169 366394013927 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 366394013928 Predicted transcriptional regulator [Transcription]; Region: COG2932 366394013929 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 366394013930 Catalytic site [active] 366394013931 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 366394013932 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 366394013933 RecT family; Region: RecT; cl04285 366394013934 Protein of unknown function (DUF968); Region: DUF968; pfam06147 366394013935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4333 366394013936 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 366394013937 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 366394013938 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 366394013939 active site 366394013940 catalytic residues [active] 366394013941 DNA binding site [nucleotide binding] 366394013942 Int/Topo IB signature motif; other site 366394013943 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 366394013944 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 366394013945 nudix motif; other site 366394013946 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 366394013947 TIGR02594 family protein; Region: TIGR02594 366394013948 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 366394013949 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 366394013950 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 366394013951 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 366394013952 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 366394013953 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394013954 cyclase homology domain; Region: CHD; cd07302 366394013955 nucleotidyl binding site; other site 366394013956 metal binding site [ion binding]; metal-binding site 366394013957 dimer interface [polypeptide binding]; other site 366394013958 Predicted integral membrane protein [Function unknown]; Region: COG5616 366394013959 TPR repeat; Region: TPR_11; pfam13414 366394013960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394013961 binding surface 366394013962 TPR motif; other site 366394013963 TPR repeat; Region: TPR_11; pfam13414 366394013964 cell division protein FtsZ; Provisional; Region: PRK13018 366394013965 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 366394013966 nucleotide binding site [chemical binding]; other site 366394013967 SulA interaction site; other site 366394013968 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 366394013969 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394013970 active site 366394013971 motif I; other site 366394013972 motif II; other site 366394013973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394013974 motif II; other site 366394013975 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394013976 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 366394013977 Walker A/P-loop; other site 366394013978 ATP binding site [chemical binding]; other site 366394013979 Q-loop/lid; other site 366394013980 ABC transporter signature motif; other site 366394013981 Walker B; other site 366394013982 D-loop; other site 366394013983 H-loop/switch region; other site 366394013984 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 366394013985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394013986 dimer interface [polypeptide binding]; other site 366394013987 conserved gate region; other site 366394013988 ABC-ATPase subunit interface; other site 366394013989 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 366394013990 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 366394013991 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 366394013992 DNA-binding site [nucleotide binding]; DNA binding site 366394013993 RNA-binding motif; other site 366394013994 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 366394013995 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 366394013996 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394013997 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 366394013998 C-terminal domain interface [polypeptide binding]; other site 366394013999 GSH binding site (G-site) [chemical binding]; other site 366394014000 dimer interface [polypeptide binding]; other site 366394014001 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 366394014002 N-terminal domain interface [polypeptide binding]; other site 366394014003 dimer interface [polypeptide binding]; other site 366394014004 substrate binding pocket (H-site) [chemical binding]; other site 366394014005 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394014006 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 366394014007 active site 366394014008 catalytic tetrad [active] 366394014009 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 366394014010 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394014011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394014012 homodimer interface [polypeptide binding]; other site 366394014013 catalytic residue [active] 366394014014 Methyltransferase domain; Region: Methyltransf_23; pfam13489 366394014015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394014016 S-adenosylmethionine binding site [chemical binding]; other site 366394014017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 366394014018 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394014019 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 366394014020 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 366394014021 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394014022 cyclase homology domain; Region: CHD; cd07302 366394014023 nucleotidyl binding site; other site 366394014024 metal binding site [ion binding]; metal-binding site 366394014025 dimer interface [polypeptide binding]; other site 366394014026 ketol-acid reductoisomerase; Provisional; Region: PRK05479 366394014027 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 366394014028 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 366394014029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394014030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394014031 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 366394014032 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 366394014033 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 366394014034 Catalytic site; other site 366394014035 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 366394014036 Phosphotransferase enzyme family; Region: APH; pfam01636 366394014037 putative active site [active] 366394014038 putative substrate binding site [chemical binding]; other site 366394014039 ATP binding site [chemical binding]; other site 366394014040 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 366394014041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 366394014042 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394014043 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394014044 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394014045 putative DNA binding site [nucleotide binding]; other site 366394014046 AsnC family; Region: AsnC_trans_reg; pfam01037 366394014047 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 366394014048 aspartate racemase; Region: asp_race; TIGR00035 366394014049 Predicted transcriptional regulators [Transcription]; Region: COG1733 366394014050 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 366394014051 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 366394014052 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 366394014053 NADP binding site [chemical binding]; other site 366394014054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 366394014055 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 366394014056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394014057 DNA-binding site [nucleotide binding]; DNA binding site 366394014058 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394014059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394014060 homodimer interface [polypeptide binding]; other site 366394014061 catalytic residue [active] 366394014062 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 366394014063 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 366394014064 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394014065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394014066 DNA binding residues [nucleotide binding] 366394014067 dimerization interface [polypeptide binding]; other site 366394014068 Acyltransferase family; Region: Acyl_transf_3; pfam01757 366394014069 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 366394014070 active site 366394014071 hydrophilic channel; other site 366394014072 dimerization interface [polypeptide binding]; other site 366394014073 catalytic residues [active] 366394014074 active site lid [active] 366394014075 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 366394014076 EF-hand domain pair; Region: EF_hand_5; pfam13499 366394014077 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 366394014078 Ca2+ binding site [ion binding]; other site 366394014079 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 366394014080 Zn binding site [ion binding]; other site 366394014081 Uncharacterized conserved protein [Function unknown]; Region: COG3482 366394014082 Uncharacterized conserved protein [Function unknown]; Region: COG1944 366394014083 YcaO-like family; Region: YcaO; pfam02624 366394014084 cyclase homology domain; Region: CHD; cd07302 366394014085 nucleotidyl binding site; other site 366394014086 metal binding site [ion binding]; metal-binding site 366394014087 dimer interface [polypeptide binding]; other site 366394014088 Predicted ATPase [General function prediction only]; Region: COG3899 366394014089 AAA ATPase domain; Region: AAA_16; pfam13191 366394014090 Predicted ATPase [General function prediction only]; Region: COG3903 366394014091 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 366394014092 AAA domain; Region: AAA_30; pfam13604 366394014093 Family description; Region: UvrD_C_2; pfam13538 366394014094 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 366394014095 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 366394014096 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 366394014097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 366394014098 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 366394014099 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 366394014100 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 366394014101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 366394014102 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 366394014103 DNA binding residues [nucleotide binding] 366394014104 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 366394014105 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 366394014106 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 366394014107 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 366394014108 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 366394014109 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 366394014110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394014111 S-adenosylmethionine binding site [chemical binding]; other site 366394014112 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 366394014113 DNA-binding site [nucleotide binding]; DNA binding site 366394014114 RNA-binding motif; other site 366394014115 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394014116 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394014117 active site 366394014118 catalytic tetrad [active] 366394014119 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 366394014120 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 366394014121 putative valine binding site [chemical binding]; other site 366394014122 dimer interface [polypeptide binding]; other site 366394014123 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 366394014124 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 366394014125 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 366394014126 PYR/PP interface [polypeptide binding]; other site 366394014127 dimer interface [polypeptide binding]; other site 366394014128 TPP binding site [chemical binding]; other site 366394014129 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 366394014130 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 366394014131 TPP-binding site [chemical binding]; other site 366394014132 dimer interface [polypeptide binding]; other site 366394014133 HAS barrel domain; Region: HAS-barrel; pfam09378 366394014134 HerA helicase [Replication, recombination, and repair]; Region: COG0433 366394014135 Domain of unknown function DUF87; Region: DUF87; pfam01935 366394014136 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 366394014137 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 366394014138 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 366394014139 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 366394014140 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 366394014141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394014142 motif II; other site 366394014143 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 366394014144 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 366394014145 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 366394014146 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 366394014147 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 366394014148 protein binding site [polypeptide binding]; other site 366394014149 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 366394014150 protein binding site [polypeptide binding]; other site 366394014151 Uncharacterized conserved protein [Function unknown]; Region: COG3603 366394014152 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 366394014153 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 366394014154 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 366394014155 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 366394014156 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 366394014157 HflK protein; Region: hflK; TIGR01933 366394014158 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 366394014159 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 366394014160 folate binding site [chemical binding]; other site 366394014161 NADP+ binding site [chemical binding]; other site 366394014162 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394014163 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 366394014164 putative C-terminal domain interface [polypeptide binding]; other site 366394014165 putative GSH binding site (G-site) [chemical binding]; other site 366394014166 putative dimer interface [polypeptide binding]; other site 366394014167 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 366394014168 N-terminal domain interface [polypeptide binding]; other site 366394014169 dimer interface [polypeptide binding]; other site 366394014170 substrate binding pocket (H-site) [chemical binding]; other site 366394014171 thymidylate synthase; Reviewed; Region: thyA; PRK01827 366394014172 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 366394014173 dimerization interface [polypeptide binding]; other site 366394014174 active site 366394014175 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 366394014176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 366394014177 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 366394014178 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 366394014179 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 366394014180 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 366394014181 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 366394014182 FAD binding domain; Region: FAD_binding_4; pfam01565 366394014183 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 366394014184 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 366394014185 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 366394014186 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 366394014187 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394014188 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 366394014189 Uncharacterized conserved protein [Function unknown]; Region: COG2128 366394014190 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 366394014191 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 366394014192 Part of AAA domain; Region: AAA_19; pfam13245 366394014193 Family description; Region: UvrD_C_2; pfam13538 366394014194 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394014195 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394014196 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394014197 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394014198 DNA binding site [nucleotide binding] 366394014199 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 366394014200 putative ligand binding site [chemical binding]; other site 366394014201 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394014202 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 366394014203 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394014204 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394014205 TM-ABC transporter signature motif; other site 366394014206 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 366394014207 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394014208 Walker A/P-loop; other site 366394014209 ATP binding site [chemical binding]; other site 366394014210 Q-loop/lid; other site 366394014211 ABC transporter signature motif; other site 366394014212 Walker B; other site 366394014213 D-loop; other site 366394014214 H-loop/switch region; other site 366394014215 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 366394014216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394014217 Coenzyme A binding pocket [chemical binding]; other site 366394014218 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 366394014219 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394014220 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394014221 metal binding site [ion binding]; metal-binding site 366394014222 active site 366394014223 I-site; other site 366394014224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 366394014225 CreA protein; Region: CreA; pfam05981 366394014226 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 366394014227 putative CheA interaction surface; other site 366394014228 HAMP domain; Region: HAMP; pfam00672 366394014229 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 366394014230 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 366394014231 dimer interface [polypeptide binding]; other site 366394014232 putative CheW interface [polypeptide binding]; other site 366394014233 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 366394014234 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 366394014235 Cu(I) binding site [ion binding]; other site 366394014236 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 366394014237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394014238 S-adenosylmethionine binding site [chemical binding]; other site 366394014239 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 366394014240 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 366394014241 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 366394014242 active site 366394014243 Predicted membrane protein [Function unknown]; Region: COG4541 366394014244 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 366394014245 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 366394014246 active site 366394014247 oligomerization interface [polypeptide binding]; other site 366394014248 metal binding site [ion binding]; metal-binding site 366394014249 pantoate--beta-alanine ligase; Region: panC; TIGR00018 366394014250 Pantoate-beta-alanine ligase; Region: PanC; cd00560 366394014251 active site 366394014252 ATP-binding site [chemical binding]; other site 366394014253 pantoate-binding site; other site 366394014254 HXXH motif; other site 366394014255 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 366394014256 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394014257 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 366394014258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014259 ABC-ATPase subunit interface; other site 366394014260 putative PBP binding loops; other site 366394014261 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394014262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014263 dimer interface [polypeptide binding]; other site 366394014264 conserved gate region; other site 366394014265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 366394014266 ABC-ATPase subunit interface; other site 366394014267 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 366394014268 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394014269 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 366394014270 Sulfatase; Region: Sulfatase; pfam00884 366394014271 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394014272 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394014273 Walker A/P-loop; other site 366394014274 ATP binding site [chemical binding]; other site 366394014275 Q-loop/lid; other site 366394014276 ABC transporter signature motif; other site 366394014277 Walker B; other site 366394014278 D-loop; other site 366394014279 H-loop/switch region; other site 366394014280 TOBE domain; Region: TOBE_2; pfam08402 366394014281 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 366394014282 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 366394014283 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 366394014284 Sulfatase; Region: Sulfatase; cl17466 366394014285 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394014286 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394014287 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 366394014288 dimerization interface [polypeptide binding]; other site 366394014289 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 366394014290 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 366394014291 nucleotide binding pocket [chemical binding]; other site 366394014292 K-X-D-G motif; other site 366394014293 catalytic site [active] 366394014294 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 366394014295 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 366394014296 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 366394014297 Dimer interface [polypeptide binding]; other site 366394014298 BRCT sequence motif; other site 366394014299 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 366394014300 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 366394014301 Walker A/P-loop; other site 366394014302 ATP binding site [chemical binding]; other site 366394014303 Q-loop/lid; other site 366394014304 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 366394014305 ABC transporter signature motif; other site 366394014306 Walker B; other site 366394014307 D-loop; other site 366394014308 H-loop/switch region; other site 366394014309 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 366394014310 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 366394014311 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 366394014312 cell division protein FtsZ; Validated; Region: PRK09330 366394014313 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 366394014314 nucleotide binding site [chemical binding]; other site 366394014315 SulA interaction site; other site 366394014316 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 366394014317 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 366394014318 Cell division protein FtsA; Region: FtsA; smart00842 366394014319 Cell division protein FtsA; Region: FtsA; pfam14450 366394014320 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 366394014321 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 366394014322 Cell division protein FtsQ; Region: FtsQ; pfam03799 366394014323 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 366394014324 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 366394014325 ATP-grasp domain; Region: ATP-grasp_4; cl17255 366394014326 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 366394014327 amphipathic channel; other site 366394014328 Asn-Pro-Ala signature motifs; other site 366394014329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394014330 metabolite-proton symporter; Region: 2A0106; TIGR00883 366394014331 putative substrate translocation pore; other site 366394014332 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 366394014333 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 366394014334 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 366394014335 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 366394014336 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 366394014337 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 366394014338 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 366394014339 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 366394014340 homodimer interface [polypeptide binding]; other site 366394014341 active site 366394014342 cell division protein FtsW; Region: ftsW; TIGR02614 366394014343 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 366394014344 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 366394014345 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 366394014346 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 366394014347 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 366394014348 Mg++ binding site [ion binding]; other site 366394014349 putative catalytic motif [active] 366394014350 putative substrate binding site [chemical binding]; other site 366394014351 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 366394014352 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 366394014353 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 366394014354 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 366394014355 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 366394014356 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 366394014357 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 366394014358 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 366394014359 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 366394014360 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 366394014361 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 366394014362 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 366394014363 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 366394014364 MraW methylase family; Region: Methyltransf_5; cl17771 366394014365 cell division protein MraZ; Reviewed; Region: PRK00326 366394014366 MraZ protein; Region: MraZ; pfam02381 366394014367 D-serine dehydratase; Provisional; Region: PRK02991 366394014368 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 366394014369 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 366394014370 catalytic residue [active] 366394014371 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 366394014372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 366394014373 hydroxyglutarate oxidase; Provisional; Region: PRK11728 366394014374 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 366394014375 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 366394014376 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 366394014377 putative active site [active] 366394014378 putative substrate binding site [chemical binding]; other site 366394014379 putative cosubstrate binding site; other site 366394014380 catalytic site [active] 366394014381 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 366394014382 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 366394014383 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 366394014384 homodimer interface [polypeptide binding]; other site 366394014385 NADP binding site [chemical binding]; other site 366394014386 substrate binding site [chemical binding]; other site 366394014387 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 366394014388 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 366394014389 dimer interface [polypeptide binding]; other site 366394014390 active site 366394014391 glycine-pyridoxal phosphate binding site [chemical binding]; other site 366394014392 folate binding site [chemical binding]; other site 366394014393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394014394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394014395 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 366394014396 putative dimerization interface [polypeptide binding]; other site 366394014397 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 366394014398 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394014399 substrate binding pocket [chemical binding]; other site 366394014400 membrane-bound complex binding site; other site 366394014401 hinge residues; other site 366394014402 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 366394014403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014404 conserved gate region; other site 366394014405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014406 dimer interface [polypeptide binding]; other site 366394014407 conserved gate region; other site 366394014408 putative PBP binding loops; other site 366394014409 ABC-ATPase subunit interface; other site 366394014410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014411 dimer interface [polypeptide binding]; other site 366394014412 conserved gate region; other site 366394014413 putative PBP binding loops; other site 366394014414 ABC-ATPase subunit interface; other site 366394014415 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 366394014416 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 366394014417 Walker A/P-loop; other site 366394014418 ATP binding site [chemical binding]; other site 366394014419 Q-loop/lid; other site 366394014420 ABC transporter signature motif; other site 366394014421 Walker B; other site 366394014422 D-loop; other site 366394014423 H-loop/switch region; other site 366394014424 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394014425 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 366394014426 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 366394014427 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 366394014428 N-acetyl-D-glucosamine binding site [chemical binding]; other site 366394014429 catalytic residue [active] 366394014430 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 366394014431 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 366394014432 amidase catalytic site [active] 366394014433 Zn binding residues [ion binding]; other site 366394014434 substrate binding site [chemical binding]; other site 366394014435 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394014436 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 366394014437 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 366394014438 putative metal binding site [ion binding]; other site 366394014439 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 366394014440 HSP70 interaction site [polypeptide binding]; other site 366394014441 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 366394014442 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 366394014443 active site 366394014444 ADP/pyrophosphate binding site [chemical binding]; other site 366394014445 dimerization interface [polypeptide binding]; other site 366394014446 allosteric effector site; other site 366394014447 fructose-1,6-bisphosphate binding site; other site 366394014448 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 366394014449 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 366394014450 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 366394014451 N-acetyl-D-glucosamine binding site [chemical binding]; other site 366394014452 catalytic residue [active] 366394014453 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 366394014454 Beta-lactamase; Region: Beta-lactamase; pfam00144 366394014455 S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379 366394014456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394014457 S-adenosylmethionine binding site [chemical binding]; other site 366394014458 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 366394014459 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 366394014460 active site 366394014461 lytic murein transglycosylase; Region: MltB_2; TIGR02283 366394014462 murein hydrolase B; Provisional; Region: PRK10760; cl17906 366394014463 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394014464 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 366394014465 EamA-like transporter family; Region: EamA; pfam00892 366394014466 EamA-like transporter family; Region: EamA; pfam00892 366394014467 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 366394014468 FAD binding site [chemical binding]; other site 366394014469 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394014470 dimerization interface [polypeptide binding]; other site 366394014471 putative DNA binding site [nucleotide binding]; other site 366394014472 putative Zn2+ binding site [ion binding]; other site 366394014473 Methyltransferase domain; Region: Methyltransf_31; pfam13847 366394014474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394014475 S-adenosylmethionine binding site [chemical binding]; other site 366394014476 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 366394014477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394014478 Walker A/P-loop; other site 366394014479 ATP binding site [chemical binding]; other site 366394014480 Q-loop/lid; other site 366394014481 ABC transporter signature motif; other site 366394014482 Walker B; other site 366394014483 D-loop; other site 366394014484 H-loop/switch region; other site 366394014485 ABC transporter; Region: ABC_tran_2; pfam12848 366394014486 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 366394014487 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 366394014488 B1 nucleotide binding pocket [chemical binding]; other site 366394014489 B2 nucleotide binding pocket [chemical binding]; other site 366394014490 CAS motifs; other site 366394014491 active site 366394014492 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 366394014493 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 366394014494 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 366394014495 EamA-like transporter family; Region: EamA; pfam00892 366394014496 thiamine pyrophosphate protein; Validated; Region: PRK08199 366394014497 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 366394014498 PYR/PP interface [polypeptide binding]; other site 366394014499 dimer interface [polypeptide binding]; other site 366394014500 TPP binding site [chemical binding]; other site 366394014501 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 366394014502 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 366394014503 TPP-binding site [chemical binding]; other site 366394014504 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394014505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394014506 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394014507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 366394014508 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 366394014509 active site 366394014510 catalytic residues [active] 366394014511 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394014512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 366394014513 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394014514 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 366394014515 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394014516 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 366394014517 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 366394014518 P-loop; other site 366394014519 Magnesium ion binding site [ion binding]; other site 366394014520 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 366394014521 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 366394014522 putative active site [active] 366394014523 metal binding site [ion binding]; metal-binding site 366394014524 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 366394014525 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 366394014526 NAD(P) binding site [chemical binding]; other site 366394014527 catalytic residues [active] 366394014528 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 366394014529 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 366394014530 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 366394014531 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 366394014532 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 366394014533 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 366394014534 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 366394014535 putative active site [active] 366394014536 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 366394014537 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 366394014538 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394014539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014540 dimer interface [polypeptide binding]; other site 366394014541 conserved gate region; other site 366394014542 putative PBP binding loops; other site 366394014543 ABC-ATPase subunit interface; other site 366394014544 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394014545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014546 dimer interface [polypeptide binding]; other site 366394014547 conserved gate region; other site 366394014548 putative PBP binding loops; other site 366394014549 ABC-ATPase subunit interface; other site 366394014550 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394014551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394014552 Walker A/P-loop; other site 366394014553 ATP binding site [chemical binding]; other site 366394014554 Q-loop/lid; other site 366394014555 ABC transporter signature motif; other site 366394014556 Walker B; other site 366394014557 D-loop; other site 366394014558 H-loop/switch region; other site 366394014559 TOBE domain; Region: TOBE_2; pfam08402 366394014560 riboflavin synthase subunit beta; Provisional; Region: PRK12419 366394014561 active site 366394014562 homopentamer interface [polypeptide binding]; other site 366394014563 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 366394014564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394014565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394014566 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 366394014567 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 366394014568 N-terminal plug; other site 366394014569 ligand-binding site [chemical binding]; other site 366394014570 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 366394014571 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 366394014572 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 366394014573 active site 366394014574 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394014575 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394014576 Walker A/P-loop; other site 366394014577 ATP binding site [chemical binding]; other site 366394014578 Q-loop/lid; other site 366394014579 ABC transporter signature motif; other site 366394014580 Walker B; other site 366394014581 D-loop; other site 366394014582 H-loop/switch region; other site 366394014583 TOBE domain; Region: TOBE; pfam03459 366394014584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 366394014585 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 366394014586 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394014587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014588 dimer interface [polypeptide binding]; other site 366394014589 conserved gate region; other site 366394014590 putative PBP binding loops; other site 366394014591 ABC-ATPase subunit interface; other site 366394014592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014593 putative PBP binding loops; other site 366394014594 ABC-ATPase subunit interface; other site 366394014595 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394014596 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394014597 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394014598 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394014599 DNA binding site [nucleotide binding] 366394014600 domain linker motif; other site 366394014601 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 366394014602 dimerization interface [polypeptide binding]; other site 366394014603 ligand binding site [chemical binding]; other site 366394014604 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 366394014605 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 366394014606 substrate binding site [chemical binding]; other site 366394014607 dimer interface [polypeptide binding]; other site 366394014608 triosephosphate isomerase; Provisional; Region: PRK14565 366394014609 catalytic triad [active] 366394014610 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 366394014611 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 366394014612 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 366394014613 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 366394014614 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 366394014615 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 366394014616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394014617 active site 366394014618 motif I; other site 366394014619 motif II; other site 366394014620 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 366394014621 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 366394014622 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 366394014623 nucleotide binding site [chemical binding]; other site 366394014624 Uncharacterized conserved protein [Function unknown]; Region: COG3347 366394014625 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 366394014626 intersubunit interface [polypeptide binding]; other site 366394014627 active site 366394014628 Zn2+ binding site [ion binding]; other site 366394014629 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 366394014630 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 366394014631 intersubunit interface [polypeptide binding]; other site 366394014632 active site 366394014633 Zn2+ binding site [ion binding]; other site 366394014634 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 366394014635 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 366394014636 putative ligand binding site [chemical binding]; other site 366394014637 putative NAD binding site [chemical binding]; other site 366394014638 catalytic site [active] 366394014639 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 366394014640 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 366394014641 putative N- and C-terminal domain interface [polypeptide binding]; other site 366394014642 putative active site [active] 366394014643 MgATP binding site [chemical binding]; other site 366394014644 catalytic site [active] 366394014645 metal binding site [ion binding]; metal-binding site 366394014646 putative xylulose binding site [chemical binding]; other site 366394014647 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394014648 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 366394014649 Walker A/P-loop; other site 366394014650 ATP binding site [chemical binding]; other site 366394014651 Q-loop/lid; other site 366394014652 ABC transporter signature motif; other site 366394014653 Walker B; other site 366394014654 D-loop; other site 366394014655 H-loop/switch region; other site 366394014656 TOBE domain; Region: TOBE_2; pfam08402 366394014657 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394014658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394014659 Walker A/P-loop; other site 366394014660 ATP binding site [chemical binding]; other site 366394014661 Q-loop/lid; other site 366394014662 ABC transporter signature motif; other site 366394014663 Walker B; other site 366394014664 D-loop; other site 366394014665 H-loop/switch region; other site 366394014666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 366394014667 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394014668 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394014669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014670 dimer interface [polypeptide binding]; other site 366394014671 conserved gate region; other site 366394014672 putative PBP binding loops; other site 366394014673 ABC-ATPase subunit interface; other site 366394014674 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394014675 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394014676 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 366394014677 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 366394014678 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394014679 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394014680 DNA binding residues [nucleotide binding] 366394014681 dimerization interface [polypeptide binding]; other site 366394014682 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394014683 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 366394014684 Walker A/P-loop; other site 366394014685 ATP binding site [chemical binding]; other site 366394014686 Q-loop/lid; other site 366394014687 ABC transporter signature motif; other site 366394014688 Walker B; other site 366394014689 D-loop; other site 366394014690 H-loop/switch region; other site 366394014691 TOBE domain; Region: TOBE_2; pfam08402 366394014692 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 366394014693 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394014694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014695 dimer interface [polypeptide binding]; other site 366394014696 conserved gate region; other site 366394014697 putative PBP binding loops; other site 366394014698 ABC-ATPase subunit interface; other site 366394014699 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394014700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014701 dimer interface [polypeptide binding]; other site 366394014702 conserved gate region; other site 366394014703 putative PBP binding loops; other site 366394014704 ABC-ATPase subunit interface; other site 366394014705 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394014706 classical (c) SDRs; Region: SDR_c; cd05233 366394014707 NAD(P) binding site [chemical binding]; other site 366394014708 active site 366394014709 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 366394014710 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 366394014711 conserved cys residue [active] 366394014712 Uncharacterized conserved protein [Function unknown]; Region: COG3246 366394014713 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531 366394014714 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 366394014715 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 366394014716 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 366394014717 active site 366394014718 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 366394014719 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 366394014720 active site 366394014721 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 366394014722 CoA binding domain; Region: CoA_binding_2; pfam13380 366394014723 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 366394014724 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 366394014725 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 366394014726 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 366394014727 substrate binding site [chemical binding]; other site 366394014728 oxyanion hole (OAH) forming residues; other site 366394014729 trimer interface [polypeptide binding]; other site 366394014730 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394014731 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 366394014732 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394014733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014734 dimer interface [polypeptide binding]; other site 366394014735 conserved gate region; other site 366394014736 ABC-ATPase subunit interface; other site 366394014737 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 366394014738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014739 dimer interface [polypeptide binding]; other site 366394014740 conserved gate region; other site 366394014741 ABC-ATPase subunit interface; other site 366394014742 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 366394014743 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394014744 Walker A/P-loop; other site 366394014745 ATP binding site [chemical binding]; other site 366394014746 Q-loop/lid; other site 366394014747 ABC transporter signature motif; other site 366394014748 Walker B; other site 366394014749 D-loop; other site 366394014750 H-loop/switch region; other site 366394014751 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394014752 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394014753 Walker A/P-loop; other site 366394014754 ATP binding site [chemical binding]; other site 366394014755 Q-loop/lid; other site 366394014756 ABC transporter signature motif; other site 366394014757 Walker B; other site 366394014758 D-loop; other site 366394014759 H-loop/switch region; other site 366394014760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394014761 sequence-specific DNA binding site [nucleotide binding]; other site 366394014762 salt bridge; other site 366394014763 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394014764 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 366394014765 Predicted acyl esterases [General function prediction only]; Region: COG2936 366394014766 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 366394014767 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 366394014768 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394014769 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394014770 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 366394014771 putative substrate binding pocket [chemical binding]; other site 366394014772 dimerization interface [polypeptide binding]; other site 366394014773 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 366394014774 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394014775 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394014776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394014777 Walker A/P-loop; other site 366394014778 ATP binding site [chemical binding]; other site 366394014779 Q-loop/lid; other site 366394014780 ABC transporter signature motif; other site 366394014781 Walker B; other site 366394014782 D-loop; other site 366394014783 H-loop/switch region; other site 366394014784 TOBE domain; Region: TOBE_2; pfam08402 366394014785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014786 putative PBP binding loops; other site 366394014787 dimer interface [polypeptide binding]; other site 366394014788 ABC-ATPase subunit interface; other site 366394014789 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394014790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394014791 dimer interface [polypeptide binding]; other site 366394014792 conserved gate region; other site 366394014793 putative PBP binding loops; other site 366394014794 ABC-ATPase subunit interface; other site 366394014795 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 366394014796 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 366394014797 tetrameric interface [polypeptide binding]; other site 366394014798 NAD binding site [chemical binding]; other site 366394014799 catalytic residues [active] 366394014800 substrate binding site [chemical binding]; other site 366394014801 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 366394014802 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 366394014803 N-terminal plug; other site 366394014804 ligand-binding site [chemical binding]; other site 366394014805 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 366394014806 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 366394014807 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 366394014808 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 366394014809 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 366394014810 putative ligand binding residues [chemical binding]; other site 366394014811 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 366394014812 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394014813 hydroxyglutarate oxidase; Provisional; Region: PRK11728 366394014814 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 366394014815 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 366394014816 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 366394014817 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394014818 hydroxyglutarate oxidase; Provisional; Region: PRK11728 366394014819 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 366394014820 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 366394014821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394014822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394014823 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 366394014824 dimerization interface [polypeptide binding]; other site 366394014825 Predicted membrane protein [Function unknown]; Region: COG4425 366394014826 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 366394014827 methionine gamma-lyase; Validated; Region: PRK07049 366394014828 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 366394014829 homodimer interface [polypeptide binding]; other site 366394014830 substrate-cofactor binding pocket; other site 366394014831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394014832 catalytic residue [active] 366394014833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394014834 non-specific DNA binding site [nucleotide binding]; other site 366394014835 salt bridge; other site 366394014836 sequence-specific DNA binding site [nucleotide binding]; other site 366394014837 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 366394014838 dimer interface [polypeptide binding]; other site 366394014839 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394014840 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394014841 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394014842 enoyl-CoA hydratase; Provisional; Region: PRK05980 366394014843 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 366394014844 substrate binding site [chemical binding]; other site 366394014845 oxyanion hole (OAH) forming residues; other site 366394014846 trimer interface [polypeptide binding]; other site 366394014847 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 366394014848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 366394014849 Putative glucoamylase; Region: Glycoamylase; pfam10091 366394014850 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 366394014851 Uncharacterized conserved protein [Function unknown]; Region: COG1944 366394014852 YcaO-like family; Region: YcaO; pfam02624 366394014853 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 366394014854 Predicted integral membrane protein [Function unknown]; Region: COG5616 366394014855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394014856 TPR motif; other site 366394014857 binding surface 366394014858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394014859 TPR motif; other site 366394014860 Tetratricopeptide repeat; Region: TPR_16; pfam13432 366394014861 binding surface 366394014862 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 366394014863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394014864 salt bridge; other site 366394014865 non-specific DNA binding site [nucleotide binding]; other site 366394014866 sequence-specific DNA binding site [nucleotide binding]; other site 366394014867 Uncharacterized conserved protein [Function unknown]; Region: COG2968 366394014868 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 366394014869 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 366394014870 Uncharacterized conserved protein [Function unknown]; Region: COG0432 366394014871 Uncharacterized conserved protein [Function unknown]; Region: COG5507 366394014872 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 366394014873 N-acetyl-D-glucosamine binding site [chemical binding]; other site 366394014874 catalytic residue [active] 366394014875 Uncharacterized conserved protein [Function unknown]; Region: COG4274 366394014876 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 366394014877 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 366394014878 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 366394014879 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 366394014880 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 366394014881 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 366394014882 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 366394014883 DNA binding residues [nucleotide binding] 366394014884 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 366394014885 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 366394014886 NAD(P) binding site [chemical binding]; other site 366394014887 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 366394014888 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 366394014889 substrate-cofactor binding pocket; other site 366394014890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394014891 catalytic residue [active] 366394014892 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 366394014893 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 366394014894 ATP binding site [chemical binding]; other site 366394014895 putative Mg++ binding site [ion binding]; other site 366394014896 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 366394014897 nucleotide binding region [chemical binding]; other site 366394014898 ATP-binding site [chemical binding]; other site 366394014899 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 366394014900 HRDC domain; Region: HRDC; pfam00570 366394014901 DNA primase; Validated; Region: dnaG; PRK05667 366394014902 CHC2 zinc finger; Region: zf-CHC2; cl17510 366394014903 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 366394014904 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 366394014905 active site 366394014906 metal binding site [ion binding]; metal-binding site 366394014907 interdomain interaction site; other site 366394014908 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 366394014909 Uncharacterized conserved protein [Function unknown]; Region: COG1610 366394014910 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 366394014911 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 366394014912 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 366394014913 catalytic site [active] 366394014914 subunit interface [polypeptide binding]; other site 366394014915 LysR family transcriptional regulator; Provisional; Region: PRK14997 366394014916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394014917 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 366394014918 putative effector binding pocket; other site 366394014919 dimerization interface [polypeptide binding]; other site 366394014920 short chain dehydrogenase; Provisional; Region: PRK06500 366394014921 classical (c) SDRs; Region: SDR_c; cd05233 366394014922 NAD(P) binding site [chemical binding]; other site 366394014923 active site 366394014924 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 366394014925 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 366394014926 aspartate aminotransferase; Provisional; Region: PRK05764 366394014927 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394014928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394014929 homodimer interface [polypeptide binding]; other site 366394014930 catalytic residue [active] 366394014931 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 366394014932 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 366394014933 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 366394014934 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 366394014935 DNA-binding site [nucleotide binding]; DNA binding site 366394014936 RNA-binding motif; other site 366394014937 BA14K-like protein; Region: BA14K; pfam07886 366394014938 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 366394014939 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 366394014940 Bacterial SH3 domain; Region: SH3_3; pfam08239 366394014941 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 366394014942 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 366394014943 MarR family; Region: MarR_2; pfam12802 366394014944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 366394014945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394014946 active site 366394014947 phosphorylation site [posttranslational modification] 366394014948 intermolecular recognition site; other site 366394014949 dimerization interface [polypeptide binding]; other site 366394014950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394014951 DNA binding site [nucleotide binding] 366394014952 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394014953 HAMP domain; Region: HAMP; pfam00672 366394014954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 366394014955 dimer interface [polypeptide binding]; other site 366394014956 phosphorylation site [posttranslational modification] 366394014957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394014958 ATP binding site [chemical binding]; other site 366394014959 Mg2+ binding site [ion binding]; other site 366394014960 G-X-G motif; other site 366394014961 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 366394014962 dimer interface [polypeptide binding]; other site 366394014963 putative tRNA-binding site [nucleotide binding]; other site 366394014964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394014965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394014966 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 366394014967 putative effector binding pocket; other site 366394014968 dimerization interface [polypeptide binding]; other site 366394014969 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 366394014970 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 366394014971 Uncharacterized conserved protein [Function unknown]; Region: COG5465 366394014972 Membrane fusogenic activity; Region: BMFP; pfam04380 366394014973 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 366394014974 Uncharacterized conserved protein [Function unknown]; Region: COG1565 366394014975 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 366394014976 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 366394014977 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 366394014978 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 366394014979 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 366394014980 active site 366394014981 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 366394014982 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 366394014983 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 366394014984 active site 366394014985 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 366394014986 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 366394014987 tetramer interface [polypeptide binding]; other site 366394014988 active site 366394014989 Mg2+/Mn2+ binding site [ion binding]; other site 366394014990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 366394014991 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 366394014992 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 366394014993 NAD(P) binding site [chemical binding]; other site 366394014994 catalytic residues [active] 366394014995 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 366394014996 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 366394014997 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 366394014998 benzoate transporter; Region: benE; TIGR00843 366394014999 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 366394015000 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 366394015001 5S rRNA interface [nucleotide binding]; other site 366394015002 CTC domain interface [polypeptide binding]; other site 366394015003 L16 interface [polypeptide binding]; other site 366394015004 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 366394015005 putative active site [active] 366394015006 catalytic residue [active] 366394015007 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 366394015008 GTP-binding protein YchF; Reviewed; Region: PRK09601 366394015009 YchF GTPase; Region: YchF; cd01900 366394015010 G1 box; other site 366394015011 GTP/Mg2+ binding site [chemical binding]; other site 366394015012 Switch I region; other site 366394015013 G2 box; other site 366394015014 Switch II region; other site 366394015015 G3 box; other site 366394015016 G4 box; other site 366394015017 G5 box; other site 366394015018 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 366394015019 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 366394015020 putative active site [active] 366394015021 putative catalytic site [active] 366394015022 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 366394015023 putative active site [active] 366394015024 putative catalytic site [active] 366394015025 Domain of unknown function (DUF1873); Region: DUF1873; pfam08969 366394015026 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 366394015027 active site 366394015028 Predicted small metal-binding protein [Function unknown]; Region: COG5466 366394015029 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 366394015030 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 366394015031 active site 366394015032 NTP binding site [chemical binding]; other site 366394015033 metal binding triad [ion binding]; metal-binding site 366394015034 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 366394015035 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 366394015036 putative active site [active] 366394015037 putative CoA binding site [chemical binding]; other site 366394015038 nudix motif; other site 366394015039 metal binding site [ion binding]; metal-binding site 366394015040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 366394015041 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 366394015042 MoxR-like ATPases [General function prediction only]; Region: COG0714 366394015043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394015044 Walker A motif; other site 366394015045 ATP binding site [chemical binding]; other site 366394015046 Walker B motif; other site 366394015047 arginine finger; other site 366394015048 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 366394015049 Protein of unknown function DUF58; Region: DUF58; pfam01882 366394015050 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 366394015051 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 366394015052 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 366394015053 CARDB; Region: CARDB; pfam07705 366394015054 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 366394015055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 366394015056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394015057 Coenzyme A binding pocket [chemical binding]; other site 366394015058 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 366394015059 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 366394015060 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 366394015061 putative dimer interface [polypeptide binding]; other site 366394015062 N-terminal domain interface [polypeptide binding]; other site 366394015063 putative substrate binding pocket (H-site) [chemical binding]; other site 366394015064 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 366394015065 nudix motif; other site 366394015066 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 366394015067 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 366394015068 putative active site [active] 366394015069 putative metal binding site [ion binding]; other site 366394015070 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 366394015071 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 366394015072 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 366394015073 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 366394015074 DNA binding residues [nucleotide binding] 366394015075 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 366394015076 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 366394015077 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 366394015078 2-isopropylmalate synthase; Validated; Region: PRK03739 366394015079 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 366394015080 active site 366394015081 catalytic residues [active] 366394015082 metal binding site [ion binding]; metal-binding site 366394015083 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 366394015084 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 366394015085 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 366394015086 oligomer interface [polypeptide binding]; other site 366394015087 active site residues [active] 366394015088 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 366394015089 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 366394015090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394015091 Coenzyme A binding pocket [chemical binding]; other site 366394015092 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 366394015093 active site 366394015094 ATP binding site [chemical binding]; other site 366394015095 Phosphotransferase enzyme family; Region: APH; pfam01636 366394015096 antibiotic binding site [chemical binding]; other site 366394015097 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 366394015098 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 366394015099 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 366394015100 anthranilate synthase; Provisional; Region: PRK13566 366394015101 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 366394015102 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 366394015103 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 366394015104 glutamine binding [chemical binding]; other site 366394015105 catalytic triad [active] 366394015106 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 366394015107 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 366394015108 N-terminal plug; other site 366394015109 ligand-binding site [chemical binding]; other site 366394015110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 366394015111 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 366394015112 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 366394015113 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 366394015114 Potassium binding sites [ion binding]; other site 366394015115 Cesium cation binding sites [ion binding]; other site 366394015116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 366394015117 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 366394015118 putative active site [active] 366394015119 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 366394015120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 366394015121 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 366394015122 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 366394015123 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 366394015124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015125 dimer interface [polypeptide binding]; other site 366394015126 conserved gate region; other site 366394015127 putative PBP binding loops; other site 366394015128 ABC-ATPase subunit interface; other site 366394015129 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 366394015130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394015131 Walker A/P-loop; other site 366394015132 ATP binding site [chemical binding]; other site 366394015133 Q-loop/lid; other site 366394015134 ABC transporter signature motif; other site 366394015135 Walker B; other site 366394015136 D-loop; other site 366394015137 H-loop/switch region; other site 366394015138 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 366394015139 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 366394015140 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 366394015141 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 366394015142 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394015143 dimerization interface [polypeptide binding]; other site 366394015144 putative DNA binding site [nucleotide binding]; other site 366394015145 putative Zn2+ binding site [ion binding]; other site 366394015146 AAA domain; Region: AAA_33; pfam13671 366394015147 AAA domain; Region: AAA_17; pfam13207 366394015148 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394015149 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394015150 Walker A/P-loop; other site 366394015151 ATP binding site [chemical binding]; other site 366394015152 Q-loop/lid; other site 366394015153 ABC transporter signature motif; other site 366394015154 Walker B; other site 366394015155 D-loop; other site 366394015156 H-loop/switch region; other site 366394015157 TOBE domain; Region: TOBE_2; pfam08402 366394015158 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 366394015159 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394015160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015161 dimer interface [polypeptide binding]; other site 366394015162 conserved gate region; other site 366394015163 putative PBP binding loops; other site 366394015164 ABC-ATPase subunit interface; other site 366394015165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015166 dimer interface [polypeptide binding]; other site 366394015167 conserved gate region; other site 366394015168 putative PBP binding loops; other site 366394015169 ABC-ATPase subunit interface; other site 366394015170 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394015171 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394015172 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394015173 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394015174 DNA binding site [nucleotide binding] 366394015175 domain linker motif; other site 366394015176 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 366394015177 dimerization interface [polypeptide binding]; other site 366394015178 ligand binding site [chemical binding]; other site 366394015179 omega amino acid--pyruvate transaminase; Provisional; Region: PRK13360 366394015180 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 366394015181 inhibitor-cofactor binding pocket; inhibition site 366394015182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394015183 catalytic residue [active] 366394015184 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 366394015185 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 366394015186 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 366394015187 active site 366394015188 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 366394015189 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 366394015190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394015191 non-specific DNA binding site [nucleotide binding]; other site 366394015192 salt bridge; other site 366394015193 sequence-specific DNA binding site [nucleotide binding]; other site 366394015194 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 366394015195 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 366394015196 active site 366394015197 catalytic site [active] 366394015198 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 366394015199 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 366394015200 substrate binding site [chemical binding]; other site 366394015201 ATP binding site [chemical binding]; other site 366394015202 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 366394015203 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394015204 Walker A/P-loop; other site 366394015205 ATP binding site [chemical binding]; other site 366394015206 Q-loop/lid; other site 366394015207 ABC transporter signature motif; other site 366394015208 Walker B; other site 366394015209 D-loop; other site 366394015210 H-loop/switch region; other site 366394015211 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 366394015212 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394015213 Walker A/P-loop; other site 366394015214 ATP binding site [chemical binding]; other site 366394015215 Q-loop/lid; other site 366394015216 ABC transporter signature motif; other site 366394015217 Walker B; other site 366394015218 D-loop; other site 366394015219 H-loop/switch region; other site 366394015220 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394015221 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 366394015222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015223 ABC-ATPase subunit interface; other site 366394015224 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394015225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015226 dimer interface [polypeptide binding]; other site 366394015227 conserved gate region; other site 366394015228 putative PBP binding loops; other site 366394015229 ABC-ATPase subunit interface; other site 366394015230 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394015231 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 366394015232 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 366394015233 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 366394015234 active site 366394015235 dimer interface [polypeptide binding]; other site 366394015236 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 366394015237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394015238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394015239 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 366394015240 apolar tunnel; other site 366394015241 heme binding site [chemical binding]; other site 366394015242 dimerization interface [polypeptide binding]; other site 366394015243 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 366394015244 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 366394015245 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 366394015246 Gram-negative bacterial tonB protein; Region: TonB; cl10048 366394015247 Hemin uptake protein hemP; Region: hemP; cl10043 366394015248 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 366394015249 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 366394015250 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 366394015251 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 366394015252 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 366394015253 putative hemin binding site; other site 366394015254 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 366394015255 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 366394015256 ABC-ATPase subunit interface; other site 366394015257 dimer interface [polypeptide binding]; other site 366394015258 putative PBP binding regions; other site 366394015259 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 366394015260 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 366394015261 Walker A/P-loop; other site 366394015262 ATP binding site [chemical binding]; other site 366394015263 Q-loop/lid; other site 366394015264 ABC transporter signature motif; other site 366394015265 Walker B; other site 366394015266 D-loop; other site 366394015267 H-loop/switch region; other site 366394015268 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 366394015269 GAF domain; Region: GAF; pfam01590 366394015270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394015271 putative active site [active] 366394015272 PAS fold; Region: PAS_3; pfam08447 366394015273 heme pocket [chemical binding]; other site 366394015274 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 366394015275 HWE histidine kinase; Region: HWE_HK; pfam07536 366394015276 RNA polymerase sigma factor; Provisional; Region: PRK12516 366394015277 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 366394015278 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 366394015279 DNA binding residues [nucleotide binding] 366394015280 two-component response regulator; Provisional; Region: PRK09191 366394015281 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 366394015282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394015283 active site 366394015284 phosphorylation site [posttranslational modification] 366394015285 intermolecular recognition site; other site 366394015286 dimerization interface [polypeptide binding]; other site 366394015287 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 366394015288 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 366394015289 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394015290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394015291 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 366394015292 putative effector binding pocket; other site 366394015293 putative dimerization interface [polypeptide binding]; other site 366394015294 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 366394015295 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 366394015296 N- and C-terminal domain interface [polypeptide binding]; other site 366394015297 active site 366394015298 MgATP binding site [chemical binding]; other site 366394015299 catalytic site [active] 366394015300 metal binding site [ion binding]; metal-binding site 366394015301 carbohydrate binding site [chemical binding]; other site 366394015302 putative homodimer interface [polypeptide binding]; other site 366394015303 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 366394015304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 366394015305 motif II; other site 366394015306 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 366394015307 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 366394015308 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 366394015309 sorbitol dehydrogenase; Provisional; Region: PRK07067 366394015310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394015311 NAD(P) binding site [chemical binding]; other site 366394015312 active site 366394015313 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394015314 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394015315 Walker A/P-loop; other site 366394015316 ATP binding site [chemical binding]; other site 366394015317 Q-loop/lid; other site 366394015318 ABC transporter signature motif; other site 366394015319 Walker B; other site 366394015320 D-loop; other site 366394015321 H-loop/switch region; other site 366394015322 TOBE domain; Region: TOBE_2; pfam08402 366394015323 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394015324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015325 dimer interface [polypeptide binding]; other site 366394015326 conserved gate region; other site 366394015327 putative PBP binding loops; other site 366394015328 ABC-ATPase subunit interface; other site 366394015329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015330 dimer interface [polypeptide binding]; other site 366394015331 conserved gate region; other site 366394015332 putative PBP binding loops; other site 366394015333 ABC-ATPase subunit interface; other site 366394015334 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394015335 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394015336 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 366394015337 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 366394015338 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 366394015339 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 366394015340 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 366394015341 homodimer interface [polypeptide binding]; other site 366394015342 active site 366394015343 FMN binding site [chemical binding]; other site 366394015344 substrate binding site [chemical binding]; other site 366394015345 4Fe-4S binding domain; Region: Fer4_6; pfam12837 366394015346 4Fe-4S binding domain; Region: Fer4; pfam00037 366394015347 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 366394015348 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 366394015349 putative NAD(P) binding site [chemical binding]; other site 366394015350 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394015351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394015352 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 366394015353 putative effector binding pocket; other site 366394015354 putative dimerization interface [polypeptide binding]; other site 366394015355 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 366394015356 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394015357 catalytic loop [active] 366394015358 iron binding site [ion binding]; other site 366394015359 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394015360 cyclase homology domain; Region: CHD; cd07302 366394015361 nucleotidyl binding site; other site 366394015362 metal binding site [ion binding]; metal-binding site 366394015363 dimer interface [polypeptide binding]; other site 366394015364 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 366394015365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394015366 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 366394015367 allantoate amidohydrolase; Reviewed; Region: PRK12893 366394015368 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 366394015369 active site 366394015370 metal binding site [ion binding]; metal-binding site 366394015371 dimer interface [polypeptide binding]; other site 366394015372 phenylhydantoinase; Validated; Region: PRK08323 366394015373 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 366394015374 tetramer interface [polypeptide binding]; other site 366394015375 active site 366394015376 Cupin domain; Region: Cupin_2; cl17218 366394015377 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 366394015378 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 366394015379 Walker A/P-loop; other site 366394015380 ATP binding site [chemical binding]; other site 366394015381 Q-loop/lid; other site 366394015382 ABC transporter signature motif; other site 366394015383 Walker B; other site 366394015384 D-loop; other site 366394015385 H-loop/switch region; other site 366394015386 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 366394015387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394015388 Coenzyme A binding pocket [chemical binding]; other site 366394015389 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 366394015390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015391 dimer interface [polypeptide binding]; other site 366394015392 conserved gate region; other site 366394015393 putative PBP binding loops; other site 366394015394 ABC-ATPase subunit interface; other site 366394015395 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 366394015396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015397 dimer interface [polypeptide binding]; other site 366394015398 conserved gate region; other site 366394015399 putative PBP binding loops; other site 366394015400 ABC-ATPase subunit interface; other site 366394015401 NMT1/THI5 like; Region: NMT1; pfam09084 366394015402 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 366394015403 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394015404 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 366394015405 Protein export membrane protein; Region: SecD_SecF; cl14618 366394015406 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 366394015407 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 366394015408 ligand binding site [chemical binding]; other site 366394015409 flexible hinge region; other site 366394015410 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 366394015411 putative switch regulator; other site 366394015412 non-specific DNA interactions [nucleotide binding]; other site 366394015413 DNA binding site [nucleotide binding] 366394015414 sequence specific DNA binding site [nucleotide binding]; other site 366394015415 putative cAMP binding site [chemical binding]; other site 366394015416 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 366394015417 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 366394015418 UreF; Region: UreF; pfam01730 366394015419 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 366394015420 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 366394015421 dimer interface [polypeptide binding]; other site 366394015422 catalytic residues [active] 366394015423 Uncharacterized conserved protein [Function unknown]; Region: COG1359 366394015424 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 366394015425 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 366394015426 catalytic triad [active] 366394015427 dimer interface [polypeptide binding]; other site 366394015428 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 366394015429 urease subunit alpha; Reviewed; Region: ureC; PRK13207 366394015430 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 366394015431 subunit interactions [polypeptide binding]; other site 366394015432 active site 366394015433 flap region; other site 366394015434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 366394015435 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 366394015436 gamma-beta subunit interface [polypeptide binding]; other site 366394015437 alpha-beta subunit interface [polypeptide binding]; other site 366394015438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 366394015439 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 366394015440 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 366394015441 alpha-gamma subunit interface [polypeptide binding]; other site 366394015442 beta-gamma subunit interface [polypeptide binding]; other site 366394015443 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 366394015444 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 366394015445 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 366394015446 dimerization interface [polypeptide binding]; other site 366394015447 ligand binding site [chemical binding]; other site 366394015448 NADP binding site [chemical binding]; other site 366394015449 catalytic site [active] 366394015450 Pepsin-like aspartic proteases, bilobal enzymes that cleave bonds in peptides at acidic pH; Region: pepsin_like; cd05471 366394015451 Eukaryotic aspartyl protease; Region: Asp; pfam00026 366394015452 inhibitor binding site; inhibition site 366394015453 catalytic motif [active] 366394015454 catalytic residue [active] 366394015455 Active site flap [active] 366394015456 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 366394015457 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 366394015458 dimerization interface [polypeptide binding]; other site 366394015459 ligand binding site [chemical binding]; other site 366394015460 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 366394015461 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 366394015462 Walker A/P-loop; other site 366394015463 ATP binding site [chemical binding]; other site 366394015464 Q-loop/lid; other site 366394015465 ABC transporter signature motif; other site 366394015466 Walker B; other site 366394015467 D-loop; other site 366394015468 H-loop/switch region; other site 366394015469 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 366394015470 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 366394015471 Walker A/P-loop; other site 366394015472 ATP binding site [chemical binding]; other site 366394015473 Q-loop/lid; other site 366394015474 ABC transporter signature motif; other site 366394015475 Walker B; other site 366394015476 D-loop; other site 366394015477 H-loop/switch region; other site 366394015478 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 366394015479 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 366394015480 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 366394015481 TM-ABC transporter signature motif; other site 366394015482 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394015483 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 366394015484 TM-ABC transporter signature motif; other site 366394015485 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 366394015486 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 366394015487 active site 366394015488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 366394015489 active site 366394015490 phosphorylation site [posttranslational modification] 366394015491 intermolecular recognition site; other site 366394015492 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 366394015493 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 366394015494 ligand binding site [chemical binding]; other site 366394015495 flexible hinge region; other site 366394015496 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 366394015497 putative switch regulator; other site 366394015498 non-specific DNA interactions [nucleotide binding]; other site 366394015499 DNA binding site [nucleotide binding] 366394015500 sequence specific DNA binding site [nucleotide binding]; other site 366394015501 putative cAMP binding site [chemical binding]; other site 366394015502 short chain dehydrogenase; Provisional; Region: PRK07326 366394015503 classical (c) SDRs; Region: SDR_c; cd05233 366394015504 NAD(P) binding site [chemical binding]; other site 366394015505 active site 366394015506 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 366394015507 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394015508 Zn binding site [ion binding]; other site 366394015509 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 366394015510 Zn binding site [ion binding]; other site 366394015511 Predicted esterase [General function prediction only]; Region: COG0400 366394015512 putative hydrolase; Provisional; Region: PRK11460 366394015513 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 366394015514 Predicted flavoprotein [General function prediction only]; Region: COG0431 366394015515 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 366394015516 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394015517 Zn binding site [ion binding]; other site 366394015518 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 366394015519 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394015520 Zn binding site [ion binding]; other site 366394015521 Predicted amidohydrolase [General function prediction only]; Region: COG0388 366394015522 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 366394015523 putative active site [active] 366394015524 catalytic triad [active] 366394015525 putative dimer interface [polypeptide binding]; other site 366394015526 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394015527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015528 dimer interface [polypeptide binding]; other site 366394015529 conserved gate region; other site 366394015530 putative PBP binding loops; other site 366394015531 ABC-ATPase subunit interface; other site 366394015532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015533 dimer interface [polypeptide binding]; other site 366394015534 conserved gate region; other site 366394015535 putative PBP binding loops; other site 366394015536 ABC-ATPase subunit interface; other site 366394015537 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394015538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394015539 Walker A/P-loop; other site 366394015540 ATP binding site [chemical binding]; other site 366394015541 Q-loop/lid; other site 366394015542 ABC transporter signature motif; other site 366394015543 Walker B; other site 366394015544 D-loop; other site 366394015545 H-loop/switch region; other site 366394015546 TOBE domain; Region: TOBE_2; pfam08402 366394015547 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 366394015548 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394015549 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 366394015550 agmatinase; Region: agmatinase; TIGR01230 366394015551 oligomer interface [polypeptide binding]; other site 366394015552 putative active site [active] 366394015553 Mn binding site [ion binding]; other site 366394015554 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 366394015555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394015556 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 366394015557 dimerization interface [polypeptide binding]; other site 366394015558 substrate binding pocket [chemical binding]; other site 366394015559 hypothetical protein; Provisional; Region: PRK07550 366394015560 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394015561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394015562 homodimer interface [polypeptide binding]; other site 366394015563 catalytic residue [active] 366394015564 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 366394015565 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 366394015566 NAD binding site [chemical binding]; other site 366394015567 catalytic residues [active] 366394015568 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 366394015569 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394015570 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 366394015571 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 366394015572 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394015573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394015574 DNA-binding site [nucleotide binding]; DNA binding site 366394015575 FCD domain; Region: FCD; pfam07729 366394015576 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394015577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394015578 DNA-binding site [nucleotide binding]; DNA binding site 366394015579 FCD domain; Region: FCD; pfam07729 366394015580 hypothetical protein; Provisional; Region: PRK05968 366394015581 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 366394015582 homodimer interface [polypeptide binding]; other site 366394015583 substrate-cofactor binding pocket; other site 366394015584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394015585 catalytic residue [active] 366394015586 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394015587 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394015588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015589 dimer interface [polypeptide binding]; other site 366394015590 conserved gate region; other site 366394015591 putative PBP binding loops; other site 366394015592 ABC-ATPase subunit interface; other site 366394015593 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394015594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015595 dimer interface [polypeptide binding]; other site 366394015596 conserved gate region; other site 366394015597 putative PBP binding loops; other site 366394015598 ABC-ATPase subunit interface; other site 366394015599 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394015600 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394015601 Walker A/P-loop; other site 366394015602 ATP binding site [chemical binding]; other site 366394015603 Q-loop/lid; other site 366394015604 ABC transporter signature motif; other site 366394015605 Walker B; other site 366394015606 D-loop; other site 366394015607 H-loop/switch region; other site 366394015608 TOBE domain; Region: TOBE_2; pfam08402 366394015609 Cytochrome c2 [Energy production and conversion]; Region: COG3474 366394015610 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 366394015611 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 366394015612 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 366394015613 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 366394015614 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 366394015615 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 366394015616 Subunit I/III interface [polypeptide binding]; other site 366394015617 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 366394015618 Subunit I/III interface [polypeptide binding]; other site 366394015619 Predicted small integral membrane protein [Function unknown]; Region: COG5605 366394015620 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394015621 hydroxyglutarate oxidase; Provisional; Region: PRK11728 366394015622 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 366394015623 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 366394015624 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 366394015625 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 366394015626 EamA-like transporter family; Region: EamA; pfam00892 366394015627 EamA-like transporter family; Region: EamA; pfam00892 366394015628 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394015629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394015630 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 366394015631 dimerization interface [polypeptide binding]; other site 366394015632 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394015633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394015634 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 366394015635 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 366394015636 putative metal binding site [ion binding]; other site 366394015637 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394015638 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 366394015639 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 366394015640 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 366394015641 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 366394015642 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394015643 Walker A/P-loop; other site 366394015644 ATP binding site [chemical binding]; other site 366394015645 Q-loop/lid; other site 366394015646 ABC transporter signature motif; other site 366394015647 Walker B; other site 366394015648 D-loop; other site 366394015649 H-loop/switch region; other site 366394015650 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394015651 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394015652 Walker A/P-loop; other site 366394015653 ATP binding site [chemical binding]; other site 366394015654 Q-loop/lid; other site 366394015655 ABC transporter signature motif; other site 366394015656 Walker B; other site 366394015657 D-loop; other site 366394015658 H-loop/switch region; other site 366394015659 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394015660 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 366394015661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015662 dimer interface [polypeptide binding]; other site 366394015663 conserved gate region; other site 366394015664 putative PBP binding loops; other site 366394015665 ABC-ATPase subunit interface; other site 366394015666 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394015667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 366394015668 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394015669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394015670 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 366394015671 putative dimerization interface [polypeptide binding]; other site 366394015672 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394015673 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394015674 TM-ABC transporter signature motif; other site 366394015675 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394015676 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394015677 Walker A/P-loop; other site 366394015678 ATP binding site [chemical binding]; other site 366394015679 Q-loop/lid; other site 366394015680 ABC transporter signature motif; other site 366394015681 Walker B; other site 366394015682 D-loop; other site 366394015683 H-loop/switch region; other site 366394015684 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394015685 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394015686 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 366394015687 ligand binding site [chemical binding]; other site 366394015688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394015689 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394015690 NAD(P) binding site [chemical binding]; other site 366394015691 active site 366394015692 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 366394015693 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 366394015694 NAD binding site [chemical binding]; other site 366394015695 catalytic residues [active] 366394015696 substrate binding site [chemical binding]; other site 366394015697 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 366394015698 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 366394015699 putative NAD(P) binding site [chemical binding]; other site 366394015700 substrate binding site [chemical binding]; other site 366394015701 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394015702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394015703 NAD(P) binding site [chemical binding]; other site 366394015704 active site 366394015705 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 366394015706 choline dehydrogenase; Validated; Region: PRK02106 366394015707 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 366394015708 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 366394015709 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394015710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394015711 Walker A/P-loop; other site 366394015712 ATP binding site [chemical binding]; other site 366394015713 Q-loop/lid; other site 366394015714 ABC transporter signature motif; other site 366394015715 Walker B; other site 366394015716 D-loop; other site 366394015717 H-loop/switch region; other site 366394015718 TOBE domain; Region: TOBE_2; pfam08402 366394015719 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394015720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394015721 Walker A/P-loop; other site 366394015722 ATP binding site [chemical binding]; other site 366394015723 Q-loop/lid; other site 366394015724 ABC transporter signature motif; other site 366394015725 Walker B; other site 366394015726 D-loop; other site 366394015727 H-loop/switch region; other site 366394015728 TOBE domain; Region: TOBE_2; pfam08402 366394015729 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394015730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015731 dimer interface [polypeptide binding]; other site 366394015732 conserved gate region; other site 366394015733 putative PBP binding loops; other site 366394015734 ABC-ATPase subunit interface; other site 366394015735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394015736 dimer interface [polypeptide binding]; other site 366394015737 conserved gate region; other site 366394015738 putative PBP binding loops; other site 366394015739 ABC-ATPase subunit interface; other site 366394015740 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394015741 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 366394015742 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 366394015743 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394015744 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394015745 DNA-binding site [nucleotide binding]; DNA binding site 366394015746 FCD domain; Region: FCD; pfam07729 366394015747 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394015748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394015749 NAD(P) binding site [chemical binding]; other site 366394015750 active site 366394015751 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 366394015752 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 366394015753 dimer interface [polypeptide binding]; other site 366394015754 active site 366394015755 metal binding site [ion binding]; metal-binding site 366394015756 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 366394015757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394015758 NAD(P) binding site [chemical binding]; other site 366394015759 active site 366394015760 short chain dehydrogenase; Provisional; Region: PRK06841 366394015761 classical (c) SDRs; Region: SDR_c; cd05233 366394015762 NAD(P) binding site [chemical binding]; other site 366394015763 active site 366394015764 glucose-6-phosphate isomerase; Provisional; Region: PRK04190 366394015765 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 366394015766 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 366394015767 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 366394015768 active site 366394015769 intersubunit interface [polypeptide binding]; other site 366394015770 catalytic residue [active] 366394015771 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 366394015772 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 366394015773 NAD(P) binding pocket [chemical binding]; other site 366394015774 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 366394015775 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 366394015776 NAD binding site [chemical binding]; other site 366394015777 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 366394015778 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 366394015779 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 366394015780 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 366394015781 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 366394015782 putative active site [active] 366394015783 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 366394015784 intersubunit interface [polypeptide binding]; other site 366394015785 active site 366394015786 catalytic residue [active] 366394015787 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 366394015788 glycerol kinase-like protein; Provisional; Region: PTZ00294 366394015789 N- and C-terminal domain interface [polypeptide binding]; other site 366394015790 active site 366394015791 MgATP binding site [chemical binding]; other site 366394015792 catalytic site [active] 366394015793 metal binding site [ion binding]; metal-binding site 366394015794 xylulose binding site [chemical binding]; other site 366394015795 putative homodimer interface [polypeptide binding]; other site 366394015796 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 366394015797 D-xylulose kinases, subgroup 3; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_3; cd07811 366394015798 putative N- and C-terminal domain interface [polypeptide binding]; other site 366394015799 putative active site [active] 366394015800 putative MgATP binding site [chemical binding]; other site 366394015801 catalytic site [active] 366394015802 metal binding site [ion binding]; metal-binding site 366394015803 putative xylulose binding site [chemical binding]; other site 366394015804 putative homodimer interface [polypeptide binding]; other site 366394015805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394015806 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 366394015807 NAD(P) binding site [chemical binding]; other site 366394015808 active site 366394015809 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394015810 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394015811 TM-ABC transporter signature motif; other site 366394015812 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394015813 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394015814 Walker A/P-loop; other site 366394015815 ATP binding site [chemical binding]; other site 366394015816 Q-loop/lid; other site 366394015817 ABC transporter signature motif; other site 366394015818 Walker B; other site 366394015819 D-loop; other site 366394015820 H-loop/switch region; other site 366394015821 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394015822 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394015823 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 366394015824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394015825 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394015826 NAD(P) binding site [chemical binding]; other site 366394015827 active site 366394015828 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 366394015829 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394015830 DNA-binding site [nucleotide binding]; DNA binding site 366394015831 UTRA domain; Region: UTRA; pfam07702 366394015832 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 366394015833 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 366394015834 N- and C-terminal domain interface [polypeptide binding]; other site 366394015835 active site 366394015836 MgATP binding site [chemical binding]; other site 366394015837 catalytic site [active] 366394015838 metal binding site [ion binding]; metal-binding site 366394015839 xylulose binding site [chemical binding]; other site 366394015840 homodimer interface [polypeptide binding]; other site 366394015841 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 366394015842 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 366394015843 TPP-binding site [chemical binding]; other site 366394015844 dimer interface [polypeptide binding]; other site 366394015845 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 366394015846 PYR/PP interface [polypeptide binding]; other site 366394015847 dimer interface [polypeptide binding]; other site 366394015848 TPP binding site [chemical binding]; other site 366394015849 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 366394015850 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 366394015851 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 366394015852 DctM-like transporters; Region: DctM; pfam06808 366394015853 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 366394015854 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 366394015855 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 366394015856 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 366394015857 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394015858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394015859 DNA-binding site [nucleotide binding]; DNA binding site 366394015860 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 366394015861 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 366394015862 FAD binding domain; Region: FAD_binding_4; pfam01565 366394015863 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394015864 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 366394015865 putative NAD(P) binding site [chemical binding]; other site 366394015866 active site 366394015867 putative substrate binding site [chemical binding]; other site 366394015868 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 366394015869 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 366394015870 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 366394015871 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 366394015872 AMP binding site [chemical binding]; other site 366394015873 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 366394015874 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 366394015875 siderophore binding site; other site 366394015876 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 366394015877 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 366394015878 ABC-ATPase subunit interface; other site 366394015879 dimer interface [polypeptide binding]; other site 366394015880 putative PBP binding regions; other site 366394015881 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 366394015882 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 366394015883 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 366394015884 ABC-ATPase subunit interface; other site 366394015885 dimer interface [polypeptide binding]; other site 366394015886 putative PBP binding regions; other site 366394015887 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 366394015888 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 366394015889 Walker A/P-loop; other site 366394015890 ATP binding site [chemical binding]; other site 366394015891 Q-loop/lid; other site 366394015892 ABC transporter signature motif; other site 366394015893 Walker B; other site 366394015894 D-loop; other site 366394015895 H-loop/switch region; other site 366394015896 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 366394015897 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 366394015898 N-terminal plug; other site 366394015899 ligand-binding site [chemical binding]; other site 366394015900 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 366394015901 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 366394015902 FAD binding pocket [chemical binding]; other site 366394015903 FAD binding motif [chemical binding]; other site 366394015904 phosphate binding motif [ion binding]; other site 366394015905 NAD binding pocket [chemical binding]; other site 366394015906 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 366394015907 Peptidase family M23; Region: Peptidase_M23; pfam01551 366394015908 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 366394015909 Clp amino terminal domain; Region: Clp_N; pfam02861 366394015910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394015911 Walker A motif; other site 366394015912 ATP binding site [chemical binding]; other site 366394015913 Walker B motif; other site 366394015914 arginine finger; other site 366394015915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394015916 Walker A motif; other site 366394015917 ATP binding site [chemical binding]; other site 366394015918 Walker B motif; other site 366394015919 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 366394015920 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 366394015921 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 366394015922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394015923 S-adenosylmethionine binding site [chemical binding]; other site 366394015924 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 366394015925 peptide chain release factor 1; Validated; Region: prfA; PRK00591 366394015926 This domain is found in peptide chain release factors; Region: PCRF; smart00937 366394015927 RF-1 domain; Region: RF-1; pfam00472 366394015928 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 366394015929 GAF domain; Region: GAF; pfam01590 366394015930 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 366394015931 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 366394015932 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 366394015933 aspartate kinase; Reviewed; Region: PRK06635 366394015934 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 366394015935 putative nucleotide binding site [chemical binding]; other site 366394015936 putative catalytic residues [active] 366394015937 putative Mg ion binding site [ion binding]; other site 366394015938 putative aspartate binding site [chemical binding]; other site 366394015939 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 366394015940 putative allosteric regulatory site; other site 366394015941 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 366394015942 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 366394015943 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 366394015944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394015945 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 366394015946 Walker A/P-loop; other site 366394015947 ATP binding site [chemical binding]; other site 366394015948 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 366394015949 Methyltransferase domain; Region: Methyltransf_11; pfam08241 366394015950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 366394015951 Predicted amidohydrolase [General function prediction only]; Region: COG0388 366394015952 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 366394015953 putative active site [active] 366394015954 catalytic triad [active] 366394015955 dimer interface [polypeptide binding]; other site 366394015956 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 366394015957 GSH binding site [chemical binding]; other site 366394015958 catalytic residues [active] 366394015959 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 366394015960 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 366394015961 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 366394015962 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 366394015963 active site 366394015964 8-oxo-dGMP binding site [chemical binding]; other site 366394015965 nudix motif; other site 366394015966 metal binding site [ion binding]; metal-binding site 366394015967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394015968 Coenzyme A binding pocket [chemical binding]; other site 366394015969 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 366394015970 heterotetramer interface [polypeptide binding]; other site 366394015971 active site pocket [active] 366394015972 cleavage site 366394015973 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 366394015974 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 366394015975 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 366394015976 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 366394015977 SEC-C motif; Region: SEC-C; pfam02810 366394015978 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 366394015979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394015980 putative substrate translocation pore; other site 366394015981 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 366394015982 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 366394015983 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 366394015984 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 366394015985 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 366394015986 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 366394015987 active site 366394015988 acyl-activating enzyme (AAE) consensus motif; other site 366394015989 putative CoA binding site [chemical binding]; other site 366394015990 AMP binding site [chemical binding]; other site 366394015991 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 366394015992 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 366394015993 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 366394015994 active site 366394015995 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 366394015996 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 366394015997 minor groove reading motif; other site 366394015998 helix-hairpin-helix signature motif; other site 366394015999 substrate binding pocket [chemical binding]; other site 366394016000 active site 366394016001 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 366394016002 active site 366394016003 HIGH motif; other site 366394016004 nucleotide binding site [chemical binding]; other site 366394016005 active site 366394016006 KMSKS motif; other site 366394016007 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 366394016008 short chain dehydrogenase; Provisional; Region: PRK05993 366394016009 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 366394016010 NADP binding site [chemical binding]; other site 366394016011 active site 366394016012 steroid binding site; other site 366394016013 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 366394016014 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 366394016015 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 366394016016 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 366394016017 Ligand binding site [chemical binding]; other site 366394016018 Electron transfer flavoprotein domain; Region: ETF; pfam01012 366394016019 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 366394016020 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 366394016021 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 366394016022 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 366394016023 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 366394016024 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 366394016025 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 366394016026 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 366394016027 catalytic residues [active] 366394016028 argininosuccinate lyase; Provisional; Region: PRK00855 366394016029 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 366394016030 active sites [active] 366394016031 tetramer interface [polypeptide binding]; other site 366394016032 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 366394016033 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 366394016034 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 366394016035 active site 366394016036 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 366394016037 substrate binding site [chemical binding]; other site 366394016038 catalytic residues [active] 366394016039 dimer interface [polypeptide binding]; other site 366394016040 TIGR02302 family protein; Region: aProt_lowcomp 366394016041 Response regulator receiver domain; Region: Response_reg; pfam00072 366394016042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394016043 active site 366394016044 phosphorylation site [posttranslational modification] 366394016045 intermolecular recognition site; other site 366394016046 dimerization interface [polypeptide binding]; other site 366394016047 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 366394016048 active site 366394016049 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 366394016050 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 366394016051 Walker A/P-loop; other site 366394016052 ATP binding site [chemical binding]; other site 366394016053 Q-loop/lid; other site 366394016054 ABC transporter signature motif; other site 366394016055 Walker B; other site 366394016056 D-loop; other site 366394016057 H-loop/switch region; other site 366394016058 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 366394016059 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 366394016060 Uncharacterized conserved protein [Function unknown]; Region: COG1434 366394016061 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 366394016062 putative active site [active] 366394016063 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 366394016064 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 366394016065 putative acyl-acceptor binding pocket; other site 366394016066 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 366394016067 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 366394016068 putative active site pocket [active] 366394016069 dimerization interface [polypeptide binding]; other site 366394016070 putative catalytic residue [active] 366394016071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 366394016072 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 366394016073 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 366394016074 prephenate dehydrogenase; Validated; Region: PRK08507 366394016075 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 366394016076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394016077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394016078 homodimer interface [polypeptide binding]; other site 366394016079 catalytic residue [active] 366394016080 Methyltransferase domain; Region: Methyltransf_23; pfam13489 366394016081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394016082 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 366394016083 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 366394016084 aromatic amino acid exporter; Provisional; Region: PRK11689 366394016085 EamA-like transporter family; Region: EamA; pfam00892 366394016086 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 366394016087 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 366394016088 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 366394016089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 366394016090 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 366394016091 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 366394016092 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 366394016093 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 366394016094 metal ion-dependent adhesion site (MIDAS); other site 366394016095 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 366394016096 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 366394016097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 366394016098 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 366394016099 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 366394016100 HSP70 interaction site [polypeptide binding]; other site 366394016101 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 366394016102 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 366394016103 Domain of unknown function DUF21; Region: DUF21; pfam01595 366394016104 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 366394016105 Transporter associated domain; Region: CorC_HlyC; smart01091 366394016106 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 366394016107 active site 366394016108 dimer interface [polypeptide binding]; other site 366394016109 metal binding site [ion binding]; metal-binding site 366394016110 shikimate kinase; Provisional; Region: PRK13946 366394016111 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 366394016112 ADP binding site [chemical binding]; other site 366394016113 magnesium binding site [ion binding]; other site 366394016114 putative shikimate binding site; other site 366394016115 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 366394016116 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 366394016117 active site 366394016118 DNA binding site [nucleotide binding] 366394016119 Int/Topo IB signature motif; other site 366394016120 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 366394016121 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 366394016122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 366394016123 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 366394016124 CPxP motif; other site 366394016125 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 366394016126 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 366394016127 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 366394016128 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 366394016129 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 366394016130 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 366394016131 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 366394016132 metal binding site [ion binding]; metal-binding site 366394016133 putative dimer interface [polypeptide binding]; other site 366394016134 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394016135 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394016136 putative DNA binding site [nucleotide binding]; other site 366394016137 putative Zn2+ binding site [ion binding]; other site 366394016138 AsnC family; Region: AsnC_trans_reg; pfam01037 366394016139 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 366394016140 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 366394016141 putative NAD(P) binding site [chemical binding]; other site 366394016142 putative substrate binding site [chemical binding]; other site 366394016143 catalytic Zn binding site [ion binding]; other site 366394016144 structural Zn binding site [ion binding]; other site 366394016145 dimer interface [polypeptide binding]; other site 366394016146 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 366394016147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394016148 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 366394016149 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394016150 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 366394016151 AsnC family; Region: AsnC_trans_reg; pfam01037 366394016152 hypothetical protein; Provisional; Region: PRK06148 366394016153 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 366394016154 active site 366394016155 ATP binding site [chemical binding]; other site 366394016156 Peptidase family M23; Region: Peptidase_M23; pfam01551 366394016157 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 366394016158 inhibitor-cofactor binding pocket; inhibition site 366394016159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394016160 catalytic residue [active] 366394016161 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 366394016162 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394016163 substrate binding pocket [chemical binding]; other site 366394016164 membrane-bound complex binding site; other site 366394016165 hinge residues; other site 366394016166 hypothetical protein; Provisional; Region: PRK06149 366394016167 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 366394016168 active site 366394016169 substrate binding site [chemical binding]; other site 366394016170 ATP binding site [chemical binding]; other site 366394016171 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 366394016172 inhibitor-cofactor binding pocket; inhibition site 366394016173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394016174 catalytic residue [active] 366394016175 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 366394016176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394016177 DNA-binding site [nucleotide binding]; DNA binding site 366394016178 UTRA domain; Region: UTRA; pfam07702 366394016179 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 366394016180 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 366394016181 active site 366394016182 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 366394016183 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 366394016184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394016185 dimer interface [polypeptide binding]; other site 366394016186 conserved gate region; other site 366394016187 putative PBP binding loops; other site 366394016188 ABC-ATPase subunit interface; other site 366394016189 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 366394016190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394016191 Walker A/P-loop; other site 366394016192 ATP binding site [chemical binding]; other site 366394016193 Q-loop/lid; other site 366394016194 ABC transporter signature motif; other site 366394016195 Walker B; other site 366394016196 D-loop; other site 366394016197 H-loop/switch region; other site 366394016198 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 366394016199 active sites [active] 366394016200 tetramer interface [polypeptide binding]; other site 366394016201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 366394016202 Nucleoside recognition; Region: Gate; pfam07670 366394016203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 366394016204 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 366394016205 homotrimer interaction site [polypeptide binding]; other site 366394016206 putative active site [active] 366394016207 tetracycline repressor protein TetR; Provisional; Region: PRK13756 366394016208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394016209 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 366394016210 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 366394016211 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 366394016212 Isochorismatase family; Region: Isochorismatase; pfam00857 366394016213 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 366394016214 catalytic triad [active] 366394016215 conserved cis-peptide bond; other site 366394016216 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 366394016217 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 366394016218 conserved cys residue [active] 366394016219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394016220 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 366394016221 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 366394016222 Ligand Binding Site [chemical binding]; other site 366394016223 Autoinducer binding domain; Region: Autoind_bind; pfam03472 366394016224 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394016225 DNA binding residues [nucleotide binding] 366394016226 dimerization interface [polypeptide binding]; other site 366394016227 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 366394016228 Predicted acetyltransferase [General function prediction only]; Region: COG2388 366394016229 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 366394016230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394016231 active site 366394016232 phosphorylation site [posttranslational modification] 366394016233 intermolecular recognition site; other site 366394016234 dimerization interface [polypeptide binding]; other site 366394016235 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394016236 DNA binding site [nucleotide binding] 366394016237 Response regulator receiver domain; Region: Response_reg; pfam00072 366394016238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394016239 active site 366394016240 phosphorylation site [posttranslational modification] 366394016241 intermolecular recognition site; other site 366394016242 dimerization interface [polypeptide binding]; other site 366394016243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 366394016244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400 366394016245 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 366394016246 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 366394016247 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 366394016248 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 366394016249 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 366394016250 RNA binding surface [nucleotide binding]; other site 366394016251 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 366394016252 active site 366394016253 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 366394016254 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 366394016255 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 366394016256 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 366394016257 DNA binding residues [nucleotide binding] 366394016258 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 366394016259 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 366394016260 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 366394016261 GDP-binding site [chemical binding]; other site 366394016262 ACT binding site; other site 366394016263 IMP binding site; other site 366394016264 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 366394016265 EamA-like transporter family; Region: EamA; pfam00892 366394016266 EamA-like transporter family; Region: EamA; pfam00892 366394016267 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 366394016268 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 366394016269 ligand binding site [chemical binding]; other site 366394016270 NAD binding site [chemical binding]; other site 366394016271 dimerization interface [polypeptide binding]; other site 366394016272 catalytic site [active] 366394016273 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 366394016274 putative L-serine binding site [chemical binding]; other site 366394016275 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 366394016276 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 366394016277 catalytic residue [active] 366394016278 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 366394016279 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 366394016280 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 366394016281 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 366394016282 active site 366394016283 substrate binding site [chemical binding]; other site 366394016284 metal binding site [ion binding]; metal-binding site 366394016285 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 366394016286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394016287 Walker A motif; other site 366394016288 ATP binding site [chemical binding]; other site 366394016289 Walker B motif; other site 366394016290 arginine finger; other site 366394016291 Peptidase family M41; Region: Peptidase_M41; pfam01434 366394016292 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 366394016293 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 366394016294 Ligand Binding Site [chemical binding]; other site 366394016295 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 366394016296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394016297 binding surface 366394016298 TPR motif; other site 366394016299 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 366394016300 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 366394016301 ligand binding site [chemical binding]; other site 366394016302 translocation protein TolB; Provisional; Region: tolB; PRK05137 366394016303 TolB amino-terminal domain; Region: TolB_N; pfam04052 366394016304 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 366394016305 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 366394016306 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 366394016307 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 366394016308 TolR protein; Region: tolR; TIGR02801 366394016309 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 366394016310 TolQ protein; Region: tolQ; TIGR02796 366394016311 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 366394016312 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 366394016313 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 366394016314 active site 366394016315 DNA binding site [nucleotide binding] 366394016316 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 366394016317 DNA binding site [nucleotide binding] 366394016318 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 366394016319 nucleotide binding site [chemical binding]; other site 366394016320 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 366394016321 active site 366394016322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394016323 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394016324 NAD(P) binding site [chemical binding]; other site 366394016325 active site 366394016326 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 366394016327 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 366394016328 substrate binding site; other site 366394016329 Manganese binding site; other site 366394016330 dimer interface; other site 366394016331 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394016332 extended (e) SDRs; Region: SDR_e; cd08946 366394016333 NAD(P) binding site [chemical binding]; other site 366394016334 active site 366394016335 substrate binding site [chemical binding]; other site 366394016336 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 366394016337 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 366394016338 putative active site [active] 366394016339 putative metal binding site [ion binding]; other site 366394016340 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 366394016341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394016342 Walker A motif; other site 366394016343 ATP binding site [chemical binding]; other site 366394016344 Walker B motif; other site 366394016345 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 366394016346 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 366394016347 RuvA N terminal domain; Region: RuvA_N; pfam01330 366394016348 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 366394016349 active site 366394016350 putative DNA-binding cleft [nucleotide binding]; other site 366394016351 dimer interface [polypeptide binding]; other site 366394016352 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 366394016353 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 366394016354 hypothetical protein; Validated; Region: PRK00110 366394016355 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 366394016356 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 366394016357 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 366394016358 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 366394016359 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 366394016360 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394016361 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 366394016362 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 366394016363 putative active site [active] 366394016364 metal binding site [ion binding]; metal-binding site 366394016365 homodimer binding site [polypeptide binding]; other site 366394016366 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 366394016367 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 366394016368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394016369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394016370 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394016371 dimerization interface [polypeptide binding]; other site 366394016372 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 366394016373 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 366394016374 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 366394016375 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 366394016376 TPP-binding site [chemical binding]; other site 366394016377 dimer interface [polypeptide binding]; other site 366394016378 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 366394016379 PYR/PP interface [polypeptide binding]; other site 366394016380 dimer interface [polypeptide binding]; other site 366394016381 TPP binding site [chemical binding]; other site 366394016382 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 366394016383 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 366394016384 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 366394016385 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 366394016386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 366394016387 Phosphoglycerate kinase; Region: PGK; pfam00162 366394016388 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 366394016389 substrate binding site [chemical binding]; other site 366394016390 hinge regions; other site 366394016391 ADP binding site [chemical binding]; other site 366394016392 catalytic site [active] 366394016393 Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: COG3588 366394016394 catalytic residue [active] 366394016395 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 366394016396 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394016397 cyclase homology domain; Region: CHD; cd07302 366394016398 nucleotidyl binding site; other site 366394016399 metal binding site [ion binding]; metal-binding site 366394016400 dimer interface [polypeptide binding]; other site 366394016401 Predicted integral membrane protein [Function unknown]; Region: COG5616 366394016402 Tetratricopeptide repeat; Region: TPR_12; pfam13424 366394016403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394016404 TPR motif; other site 366394016405 TPR repeat; Region: TPR_11; pfam13414 366394016406 binding surface 366394016407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394016408 binding surface 366394016409 TPR motif; other site 366394016410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394016411 putative substrate translocation pore; other site 366394016412 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 366394016413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 366394016414 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 366394016415 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 366394016416 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 366394016417 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 366394016418 Walker A/P-loop; other site 366394016419 ATP binding site [chemical binding]; other site 366394016420 Q-loop/lid; other site 366394016421 ABC transporter signature motif; other site 366394016422 Walker B; other site 366394016423 D-loop; other site 366394016424 H-loop/switch region; other site 366394016425 hypothetical protein; Validated; Region: PRK09039 366394016426 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 366394016427 ligand binding site [chemical binding]; other site 366394016428 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 366394016429 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 366394016430 active site 366394016431 dimerization interface [polypeptide binding]; other site 366394016432 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 366394016433 Sel1-like repeats; Region: SEL1; smart00671 366394016434 Sel1-like repeats; Region: SEL1; smart00671 366394016435 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 366394016436 thiamine phosphate binding site [chemical binding]; other site 366394016437 active site 366394016438 pyrophosphate binding site [ion binding]; other site 366394016439 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 366394016440 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394016441 dimerization interface [polypeptide binding]; other site 366394016442 putative DNA binding site [nucleotide binding]; other site 366394016443 putative Zn2+ binding site [ion binding]; other site 366394016444 Uncharacterized small protein [Function unknown]; Region: COG5570 366394016445 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 366394016446 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 366394016447 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 366394016448 ATP-grasp domain; Region: ATP-grasp; pfam02222 366394016449 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 366394016450 TPR repeat; Region: TPR_11; pfam13414 366394016451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394016452 TPR motif; other site 366394016453 binding surface 366394016454 TPR repeat; Region: TPR_11; pfam13414 366394016455 pyruvate kinase; Provisional; Region: PRK06247 366394016456 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 366394016457 domain interfaces; other site 366394016458 active site 366394016459 Predicted integral membrane protein [Function unknown]; Region: COG5480 366394016460 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 366394016461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 366394016462 hypothetical protein; Provisional; Region: PRK13694 366394016463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 366394016464 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 366394016465 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 366394016466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394016467 active site 366394016468 phosphorylation site [posttranslational modification] 366394016469 intermolecular recognition site; other site 366394016470 dimerization interface [polypeptide binding]; other site 366394016471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394016472 Walker A motif; other site 366394016473 ATP binding site [chemical binding]; other site 366394016474 Walker B motif; other site 366394016475 arginine finger; other site 366394016476 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 366394016477 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 366394016478 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 366394016479 active site 366394016480 Zn binding site [ion binding]; other site 366394016481 aminodeoxychorismate synthase; Provisional; Region: PRK07508 366394016482 chorismate binding enzyme; Region: Chorismate_bind; cl10555 366394016483 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 366394016484 hypothetical protein; Provisional; Region: PRK07546 366394016485 substrate-cofactor binding pocket; other site 366394016486 homodimer interface [polypeptide binding]; other site 366394016487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394016488 catalytic residue [active] 366394016489 PAS fold; Region: PAS_7; pfam12860 366394016490 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394016491 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394016492 metal binding site [ion binding]; metal-binding site 366394016493 active site 366394016494 I-site; other site 366394016495 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 366394016496 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 366394016497 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 366394016498 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 366394016499 active site 366394016500 metal binding site [ion binding]; metal-binding site 366394016501 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 366394016502 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 366394016503 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 366394016504 ferrochelatase; Reviewed; Region: hemH; PRK00035 366394016505 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 366394016506 C-terminal domain interface [polypeptide binding]; other site 366394016507 active site 366394016508 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 366394016509 active site 366394016510 N-terminal domain interface [polypeptide binding]; other site 366394016511 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 366394016512 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 366394016513 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 366394016514 short chain dehydrogenase; Validated; Region: PRK08324 366394016515 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 366394016516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394016517 NAD(P) binding site [chemical binding]; other site 366394016518 active site 366394016519 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394016520 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394016521 Walker A/P-loop; other site 366394016522 ATP binding site [chemical binding]; other site 366394016523 Q-loop/lid; other site 366394016524 ABC transporter signature motif; other site 366394016525 Walker B; other site 366394016526 D-loop; other site 366394016527 H-loop/switch region; other site 366394016528 TOBE domain; Region: TOBE_2; pfam08402 366394016529 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 366394016530 classical (c) SDRs; Region: SDR_c; cd05233 366394016531 NAD(P) binding site [chemical binding]; other site 366394016532 active site 366394016533 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394016534 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394016535 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394016536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394016537 dimer interface [polypeptide binding]; other site 366394016538 conserved gate region; other site 366394016539 putative PBP binding loops; other site 366394016540 ABC-ATPase subunit interface; other site 366394016541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394016542 dimer interface [polypeptide binding]; other site 366394016543 conserved gate region; other site 366394016544 putative PBP binding loops; other site 366394016545 ABC-ATPase subunit interface; other site 366394016546 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 366394016547 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 366394016548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 366394016549 active site 366394016550 motif I; other site 366394016551 motif II; other site 366394016552 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 366394016553 active site 366394016554 metal binding site [ion binding]; metal-binding site 366394016555 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 366394016556 Helix-turn-helix domain; Region: HTH_28; pfam13518 366394016557 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 366394016558 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 366394016559 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 366394016560 putative N- and C-terminal domain interface [polypeptide binding]; other site 366394016561 putative active site [active] 366394016562 MgATP binding site [chemical binding]; other site 366394016563 catalytic site [active] 366394016564 metal binding site [ion binding]; metal-binding site 366394016565 putative carbohydrate binding site [chemical binding]; other site 366394016566 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 366394016567 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 366394016568 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 366394016569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338 366394016570 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 366394016571 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 366394016572 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 366394016573 active site 366394016574 tetramer interface; other site 366394016575 Transglycosylase SLT domain; Region: SLT_2; pfam13406 366394016576 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 366394016577 N-acetyl-D-glucosamine binding site [chemical binding]; other site 366394016578 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394016579 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 366394016580 active site 366394016581 catalytic triad [active] 366394016582 oxyanion hole [active] 366394016583 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 366394016584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394016585 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 366394016586 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 366394016587 active site 366394016588 dimer interface [polypeptide binding]; other site 366394016589 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 366394016590 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 366394016591 active site 366394016592 FMN binding site [chemical binding]; other site 366394016593 substrate binding site [chemical binding]; other site 366394016594 3Fe-4S cluster binding site [ion binding]; other site 366394016595 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 366394016596 domain interface; other site 366394016597 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 366394016598 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 366394016599 tetramer interface [polypeptide binding]; other site 366394016600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394016601 catalytic residue [active] 366394016602 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394016603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394016604 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394016605 dimerization interface [polypeptide binding]; other site 366394016606 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 366394016607 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 366394016608 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 366394016609 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 366394016610 putative dimer interface [polypeptide binding]; other site 366394016611 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 366394016612 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 366394016613 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 366394016614 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 366394016615 active site 366394016616 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 366394016617 Response regulator receiver domain; Region: Response_reg; pfam00072 366394016618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394016619 active site 366394016620 phosphorylation site [posttranslational modification] 366394016621 intermolecular recognition site; other site 366394016622 dimerization interface [polypeptide binding]; other site 366394016623 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 366394016624 HicB family; Region: HicB; pfam05534 366394016625 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 366394016626 Sel1-like repeats; Region: SEL1; smart00671 366394016627 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 366394016628 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394016629 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 366394016630 MarR family; Region: MarR_2; pfam12802 366394016631 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 366394016632 pseudoazurin; Region: pseudoazurin; TIGR02375 366394016633 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 366394016634 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 366394016635 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 366394016636 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 366394016637 Moco binding site; other site 366394016638 metal coordination site [ion binding]; other site 366394016639 dimerization interface [polypeptide binding]; other site 366394016640 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 366394016641 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 366394016642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 366394016643 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 366394016644 DNA binding residues [nucleotide binding] 366394016645 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 366394016646 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 366394016647 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 366394016648 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394016649 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 366394016650 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 366394016651 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394016652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394016653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394016654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 366394016655 dimerization interface [polypeptide binding]; other site 366394016656 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394016657 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394016658 active site 366394016659 catalytic tetrad [active] 366394016660 Uncharacterized conserved protein [Function unknown]; Region: COG2308 366394016661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 366394016662 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 366394016663 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 366394016664 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 366394016665 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 366394016666 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 366394016667 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 366394016668 metal ion-dependent adhesion site (MIDAS); other site 366394016669 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 366394016670 homodimer interface [polypeptide binding]; other site 366394016671 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 366394016672 active site pocket [active] 366394016673 glycogen branching enzyme; Provisional; Region: PRK05402 366394016674 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 366394016675 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 366394016676 active site 366394016677 catalytic site [active] 366394016678 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 366394016679 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 366394016680 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 366394016681 ligand binding site; other site 366394016682 oligomer interface; other site 366394016683 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 366394016684 dimer interface [polypeptide binding]; other site 366394016685 N-terminal domain interface [polypeptide binding]; other site 366394016686 sulfate 1 binding site; other site 366394016687 glycogen synthase; Provisional; Region: glgA; PRK00654 366394016688 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 366394016689 ADP-binding pocket [chemical binding]; other site 366394016690 homodimer interface [polypeptide binding]; other site 366394016691 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 366394016692 phosphoglucomutase; Region: PLN02307 366394016693 substrate binding site [chemical binding]; other site 366394016694 dimer interface [polypeptide binding]; other site 366394016695 active site 366394016696 metal binding site [ion binding]; metal-binding site 366394016697 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 366394016698 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 366394016699 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 366394016700 active site 366394016701 catalytic site [active] 366394016702 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 366394016703 putative active site [active] 366394016704 putative catalytic site [active] 366394016705 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 366394016706 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 366394016707 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 366394016708 NAD binding site [chemical binding]; other site 366394016709 catalytic Zn binding site [ion binding]; other site 366394016710 substrate binding site [chemical binding]; other site 366394016711 structural Zn binding site [ion binding]; other site 366394016712 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 366394016713 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 366394016714 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 366394016715 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 366394016716 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 366394016717 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 366394016718 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 366394016719 hydroxyglutarate oxidase; Provisional; Region: PRK11728 366394016720 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 366394016721 TPR repeat; Region: TPR_11; pfam13414 366394016722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394016723 TPR motif; other site 366394016724 binding surface 366394016725 TPR repeat; Region: TPR_11; pfam13414 366394016726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394016727 binding surface 366394016728 TPR motif; other site 366394016729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394016730 TPR repeat; Region: TPR_11; pfam13414 366394016731 binding surface 366394016732 TPR motif; other site 366394016733 Protein of unknown function (DUF992); Region: DUF992; pfam06186 366394016734 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394016735 cyclase homology domain; Region: CHD; cd07302 366394016736 nucleotidyl binding site; other site 366394016737 metal binding site [ion binding]; metal-binding site 366394016738 dimer interface [polypeptide binding]; other site 366394016739 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 366394016740 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 366394016741 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 366394016742 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 366394016743 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 366394016744 ligand binding site [chemical binding]; other site 366394016745 homodimer interface [polypeptide binding]; other site 366394016746 NAD(P) binding site [chemical binding]; other site 366394016747 trimer interface B [polypeptide binding]; other site 366394016748 trimer interface A [polypeptide binding]; other site 366394016749 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 366394016750 PAS domain; Region: PAS; smart00091 366394016751 PAS fold; Region: PAS_7; pfam12860 366394016752 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394016753 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394016754 metal binding site [ion binding]; metal-binding site 366394016755 active site 366394016756 I-site; other site 366394016757 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 366394016758 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 366394016759 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 366394016760 catalytic triad [active] 366394016761 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 366394016762 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 366394016763 putative ligand binding site [chemical binding]; other site 366394016764 NAD binding site [chemical binding]; other site 366394016765 catalytic site [active] 366394016766 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394016767 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394016768 DNA binding site [nucleotide binding] 366394016769 domain linker motif; other site 366394016770 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 366394016771 putative dimerization interface [polypeptide binding]; other site 366394016772 putative ligand binding site [chemical binding]; other site 366394016773 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 366394016774 MarR family; Region: MarR_2; cl17246 366394016775 Creatinine amidohydrolase; Region: Creatininase; pfam02633 366394016776 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 366394016777 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 366394016778 P-loop, Walker A motif; other site 366394016779 Base recognition motif; other site 366394016780 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 366394016781 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 366394016782 structural tetrad; other site 366394016783 FOG: WD40 repeat [General function prediction only]; Region: COG2319 366394016784 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 366394016785 Predicted acetyltransferase [General function prediction only]; Region: COG3153 366394016786 Coenzyme A binding pocket [chemical binding]; other site 366394016787 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 366394016788 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 366394016789 dimer interface [polypeptide binding]; other site 366394016790 active site 366394016791 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 366394016792 catalytic residues [active] 366394016793 substrate binding site [chemical binding]; other site 366394016794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394016795 LysR family transcriptional regulator; Provisional; Region: PRK14997 366394016796 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 366394016797 putative effector binding pocket; other site 366394016798 dimerization interface [polypeptide binding]; other site 366394016799 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 366394016800 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 366394016801 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 366394016802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 366394016803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 366394016804 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 366394016805 putative metal binding site [ion binding]; other site 366394016806 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 366394016807 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 366394016808 active site 366394016809 intersubunit interface [polypeptide binding]; other site 366394016810 catalytic residue [active] 366394016811 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 366394016812 putative active site [active] 366394016813 putative metal binding residues [ion binding]; other site 366394016814 signature motif; other site 366394016815 putative dimer interface [polypeptide binding]; other site 366394016816 putative phosphate binding site [ion binding]; other site 366394016817 CHAD domain; Region: CHAD; pfam05235 366394016818 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 366394016819 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 366394016820 active site residue [active] 366394016821 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 366394016822 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 366394016823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394016824 dimer interface [polypeptide binding]; other site 366394016825 conserved gate region; other site 366394016826 ABC-ATPase subunit interface; other site 366394016827 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 366394016828 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 366394016829 Walker A/P-loop; other site 366394016830 ATP binding site [chemical binding]; other site 366394016831 Q-loop/lid; other site 366394016832 ABC transporter signature motif; other site 366394016833 Walker B; other site 366394016834 D-loop; other site 366394016835 H-loop/switch region; other site 366394016836 NIL domain; Region: NIL; pfam09383 366394016837 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 366394016838 beta-galactosidase; Region: BGL; TIGR03356 366394016839 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394016840 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394016841 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394016842 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 366394016843 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 366394016844 xylose isomerase; Provisional; Region: PRK05474 366394016845 xylose isomerase; Region: xylose_isom_A; TIGR02630 366394016846 SnoaL-like domain; Region: SnoaL_2; pfam12680 366394016847 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 366394016848 N- and C-terminal domain interface [polypeptide binding]; other site 366394016849 D-xylulose kinase; Region: XylB; TIGR01312 366394016850 active site 366394016851 MgATP binding site [chemical binding]; other site 366394016852 catalytic site [active] 366394016853 metal binding site [ion binding]; metal-binding site 366394016854 xylulose binding site [chemical binding]; other site 366394016855 homodimer interface [polypeptide binding]; other site 366394016856 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394016857 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394016858 DNA binding site [nucleotide binding] 366394016859 domain linker motif; other site 366394016860 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 366394016861 putative ligand binding site [chemical binding]; other site 366394016862 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 366394016863 Active site serine [active] 366394016864 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 366394016865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394016866 putative substrate translocation pore; other site 366394016867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394016868 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 366394016869 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 366394016870 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394016871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 366394016872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394016873 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 366394016874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394016875 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 366394016876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394016877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 366394016878 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 366394016879 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 366394016880 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 366394016881 HIGH motif; other site 366394016882 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 366394016883 active site 366394016884 KMSKS motif; other site 366394016885 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 366394016886 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 366394016887 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 366394016888 active site residue [active] 366394016889 dimer interface [polypeptide binding]; other site 366394016890 putative anticodon binding site; other site 366394016891 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 366394016892 motif 1; other site 366394016893 active site 366394016894 motif 2; other site 366394016895 motif 3; other site 366394016896 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 366394016897 active site 366394016898 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 366394016899 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 366394016900 ATP-dependent DNA ligase; Validated; Region: PRK09247 366394016901 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 366394016902 active site 366394016903 DNA binding site [nucleotide binding] 366394016904 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 366394016905 DNA binding site [nucleotide binding] 366394016906 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3452 366394016907 PAS fold; Region: PAS_3; pfam08447 366394016908 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394016909 metal binding site [ion binding]; metal-binding site 366394016910 active site 366394016911 I-site; other site 366394016912 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 366394016913 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 366394016914 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 366394016915 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 366394016916 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 366394016917 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 366394016918 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 366394016919 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 366394016920 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 366394016921 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 366394016922 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 366394016923 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 366394016924 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 366394016925 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 366394016926 active site 366394016927 SAM binding site [chemical binding]; other site 366394016928 homodimer interface [polypeptide binding]; other site 366394016929 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 366394016930 active site 366394016931 putative homodimer interface [polypeptide binding]; other site 366394016932 SAM binding site [chemical binding]; other site 366394016933 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 366394016934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394016935 S-adenosylmethionine binding site [chemical binding]; other site 366394016936 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 366394016937 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 366394016938 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 366394016939 active site 366394016940 SAM binding site [chemical binding]; other site 366394016941 homodimer interface [polypeptide binding]; other site 366394016942 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 366394016943 active site 366394016944 SAM binding site [chemical binding]; other site 366394016945 homodimer interface [polypeptide binding]; other site 366394016946 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 366394016947 Precorrin-8X methylmutase; Region: CbiC; pfam02570 366394016948 precorrin-3B synthase; Region: CobG; TIGR02435 366394016949 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 366394016950 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 366394016951 active site 366394016952 SAM binding site [chemical binding]; other site 366394016953 homodimer interface [polypeptide binding]; other site 366394016954 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 366394016955 ligand binding site [chemical binding]; other site 366394016956 active site 366394016957 UGI interface [polypeptide binding]; other site 366394016958 catalytic site [active] 366394016959 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 366394016960 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 366394016961 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 366394016962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394016963 dimer interface [polypeptide binding]; other site 366394016964 conserved gate region; other site 366394016965 putative PBP binding loops; other site 366394016966 ABC-ATPase subunit interface; other site 366394016967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394016968 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 366394016969 Walker A/P-loop; other site 366394016970 ATP binding site [chemical binding]; other site 366394016971 Q-loop/lid; other site 366394016972 ABC transporter signature motif; other site 366394016973 Walker B; other site 366394016974 D-loop; other site 366394016975 H-loop/switch region; other site 366394016976 TOBE domain; Region: TOBE; cl01440 366394016977 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 366394016978 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394016979 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 366394016980 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 366394016981 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 366394016982 tetramer interface [polypeptide binding]; other site 366394016983 TPP-binding site [chemical binding]; other site 366394016984 heterodimer interface [polypeptide binding]; other site 366394016985 phosphorylation loop region [posttranslational modification] 366394016986 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 366394016987 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 366394016988 alpha subunit interface [polypeptide binding]; other site 366394016989 TPP binding site [chemical binding]; other site 366394016990 heterodimer interface [polypeptide binding]; other site 366394016991 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 366394016992 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 366394016993 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 366394016994 E3 interaction surface; other site 366394016995 lipoyl attachment site [posttranslational modification]; other site 366394016996 e3 binding domain; Region: E3_binding; pfam02817 366394016997 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 366394016998 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 366394016999 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 366394017000 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394017001 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 366394017002 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 366394017003 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 366394017004 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 366394017005 putative active site [active] 366394017006 putative substrate binding site [chemical binding]; other site 366394017007 putative cosubstrate binding site; other site 366394017008 catalytic site [active] 366394017009 maleylacetoacetate isomerase; Region: maiA; TIGR01262 366394017010 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 366394017011 C-terminal domain interface [polypeptide binding]; other site 366394017012 GSH binding site (G-site) [chemical binding]; other site 366394017013 putative dimer interface [polypeptide binding]; other site 366394017014 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 366394017015 dimer interface [polypeptide binding]; other site 366394017016 N-terminal domain interface [polypeptide binding]; other site 366394017017 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 366394017018 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 366394017019 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 366394017020 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 366394017021 Transcriptional regulators [Transcription]; Region: MarR; COG1846 366394017022 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394017023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394017024 putative DNA binding site [nucleotide binding]; other site 366394017025 putative Zn2+ binding site [ion binding]; other site 366394017026 AsnC family; Region: AsnC_trans_reg; pfam01037 366394017027 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 366394017028 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 366394017029 dimer interface [polypeptide binding]; other site 366394017030 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 366394017031 active site 366394017032 Fe binding site [ion binding]; other site 366394017033 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 366394017034 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394017035 DNA binding residues [nucleotide binding] 366394017036 dimerization interface [polypeptide binding]; other site 366394017037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394017038 binding surface 366394017039 Tetratricopeptide repeat; Region: TPR_16; pfam13432 366394017040 TPR motif; other site 366394017041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 366394017042 TPR motif; other site 366394017043 Tetratricopeptide repeat; Region: TPR_16; pfam13432 366394017044 binding surface 366394017045 Methyltransferase domain; Region: Methyltransf_25; pfam13649 366394017046 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 366394017047 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 366394017048 metal binding site [ion binding]; metal-binding site 366394017049 active site 366394017050 I-site; other site 366394017051 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 366394017052 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 366394017053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394017054 DNA-binding site [nucleotide binding]; DNA binding site 366394017055 UTRA domain; Region: UTRA; pfam07702 366394017056 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 366394017057 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 366394017058 putative active site [active] 366394017059 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 366394017060 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 366394017061 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 366394017062 substrate binding site [chemical binding]; other site 366394017063 ATP binding site [chemical binding]; other site 366394017064 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 366394017065 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 366394017066 Walker A/P-loop; other site 366394017067 ATP binding site [chemical binding]; other site 366394017068 Q-loop/lid; other site 366394017069 ABC transporter signature motif; other site 366394017070 Walker B; other site 366394017071 D-loop; other site 366394017072 H-loop/switch region; other site 366394017073 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 366394017074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394017075 dimer interface [polypeptide binding]; other site 366394017076 conserved gate region; other site 366394017077 putative PBP binding loops; other site 366394017078 ABC-ATPase subunit interface; other site 366394017079 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 366394017080 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 366394017081 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 366394017082 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394017083 substrate binding pocket [chemical binding]; other site 366394017084 membrane-bound complex binding site; other site 366394017085 hinge residues; other site 366394017086 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 366394017087 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 366394017088 AP (apurinic/apyrimidinic) site pocket; other site 366394017089 DNA interaction; other site 366394017090 Metal-binding active site; metal-binding site 366394017091 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 366394017092 Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565 366394017093 active site 366394017094 catalytic site [active] 366394017095 metal binding site [ion binding]; metal-binding site 366394017096 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 366394017097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 366394017098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394017099 dimer interface [polypeptide binding]; other site 366394017100 conserved gate region; other site 366394017101 putative PBP binding loops; other site 366394017102 ABC-ATPase subunit interface; other site 366394017103 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394017104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394017105 dimer interface [polypeptide binding]; other site 366394017106 conserved gate region; other site 366394017107 putative PBP binding loops; other site 366394017108 ABC-ATPase subunit interface; other site 366394017109 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 366394017110 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394017111 Walker A/P-loop; other site 366394017112 ATP binding site [chemical binding]; other site 366394017113 Q-loop/lid; other site 366394017114 ABC transporter signature motif; other site 366394017115 Walker B; other site 366394017116 D-loop; other site 366394017117 H-loop/switch region; other site 366394017118 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 366394017119 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 366394017120 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394017121 Walker A/P-loop; other site 366394017122 ATP binding site [chemical binding]; other site 366394017123 Q-loop/lid; other site 366394017124 ABC transporter signature motif; other site 366394017125 Walker B; other site 366394017126 D-loop; other site 366394017127 H-loop/switch region; other site 366394017128 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 366394017129 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394017130 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 366394017131 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 366394017132 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 366394017133 DNA binding residues [nucleotide binding] 366394017134 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 366394017135 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 366394017136 putative active site [active] 366394017137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 366394017138 HTH-like domain; Region: HTH_21; pfam13276 366394017139 Integrase core domain; Region: rve; pfam00665 366394017140 Integrase core domain; Region: rve_3; pfam13683 366394017141 Transposase; Region: HTH_Tnp_1; pfam01527 366394017142 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 366394017143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394017144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394017145 LysR substrate binding domain; Region: LysR_substrate; pfam03466 366394017146 dimerization interface [polypeptide binding]; other site 366394017147 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 366394017148 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 366394017149 putative ligand binding site [chemical binding]; other site 366394017150 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 366394017151 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 366394017152 Walker A/P-loop; other site 366394017153 ATP binding site [chemical binding]; other site 366394017154 Q-loop/lid; other site 366394017155 ABC transporter signature motif; other site 366394017156 Walker B; other site 366394017157 D-loop; other site 366394017158 H-loop/switch region; other site 366394017159 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 366394017160 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 366394017161 Walker A/P-loop; other site 366394017162 ATP binding site [chemical binding]; other site 366394017163 Q-loop/lid; other site 366394017164 ABC transporter signature motif; other site 366394017165 Walker B; other site 366394017166 D-loop; other site 366394017167 H-loop/switch region; other site 366394017168 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 366394017169 TM-ABC transporter signature motif; other site 366394017170 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 366394017171 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 366394017172 TM-ABC transporter signature motif; other site 366394017173 choline dehydrogenase; Validated; Region: PRK02106 366394017174 lycopene cyclase; Region: lycopene_cycl; TIGR01789 366394017175 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 366394017176 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 366394017177 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 366394017178 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 366394017179 substrate binding pocket [chemical binding]; other site 366394017180 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 366394017181 B12 binding site [chemical binding]; other site 366394017182 cobalt ligand [ion binding]; other site 366394017183 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 366394017184 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 366394017185 dimerization interface [polypeptide binding]; other site 366394017186 putative active cleft [active] 366394017187 hypothetical protein; Provisional; Region: PRK02487 366394017188 fructokinase; Reviewed; Region: PRK09557 366394017189 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 366394017190 nucleotide binding site [chemical binding]; other site 366394017191 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 366394017192 DNA-binding site [nucleotide binding]; DNA binding site 366394017193 RNA-binding motif; other site 366394017194 PRC-barrel domain; Region: PRC; pfam05239 366394017195 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 366394017196 Predicted periplasmic protein [General function prediction only]; Region: COG3895 366394017197 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 366394017198 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 366394017199 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 366394017200 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 366394017201 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 366394017202 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 366394017203 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 366394017204 substrate-cofactor binding pocket; other site 366394017205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394017206 catalytic residue [active] 366394017207 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 366394017208 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 366394017209 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 366394017210 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 366394017211 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 366394017212 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 366394017213 catalytic loop [active] 366394017214 iron binding site [ion binding]; other site 366394017215 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 366394017216 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394017217 cyclase homology domain; Region: CHD; cd07302 366394017218 nucleotidyl binding site; other site 366394017219 metal binding site [ion binding]; metal-binding site 366394017220 dimer interface [polypeptide binding]; other site 366394017221 Predicted integral membrane protein [Function unknown]; Region: COG5616 366394017222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394017223 TPR motif; other site 366394017224 binding surface 366394017225 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 366394017226 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 366394017227 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 366394017228 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 366394017229 Surface antigen; Region: Bac_surface_Ag; pfam01103 366394017230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 366394017231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 366394017232 Family of unknown function (DUF490); Region: DUF490; pfam04357 366394017233 Family of unknown function (DUF490); Region: DUF490; pfam04357 366394017234 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 366394017235 putative dimer interface [polypeptide binding]; other site 366394017236 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394017237 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394017238 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 366394017239 AsnC family; Region: AsnC_trans_reg; pfam01037 366394017240 Arginase family; Region: Arginase; cd09989 366394017241 active site 366394017242 Mn binding site [ion binding]; other site 366394017243 oligomer interface [polypeptide binding]; other site 366394017244 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 366394017245 putative CheA interaction surface; other site 366394017246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394017247 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 366394017248 putative active site [active] 366394017249 heme pocket [chemical binding]; other site 366394017250 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 366394017251 putative active site [active] 366394017252 heme pocket [chemical binding]; other site 366394017253 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 366394017254 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 366394017255 dimer interface [polypeptide binding]; other site 366394017256 putative CheW interface [polypeptide binding]; other site 366394017257 Transposase; Region: DEDD_Tnp_IS110; pfam01548 366394017258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 366394017259 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 366394017260 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 366394017261 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 366394017262 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 366394017263 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394017264 catalytic loop [active] 366394017265 iron binding site [ion binding]; other site 366394017266 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 366394017267 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 366394017268 [4Fe-4S] binding site [ion binding]; other site 366394017269 molybdopterin cofactor binding site; other site 366394017270 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 366394017271 molybdopterin cofactor binding site; other site 366394017272 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 366394017273 putative dimer interface [polypeptide binding]; other site 366394017274 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 366394017275 SLBB domain; Region: SLBB; pfam10531 366394017276 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 366394017277 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 366394017278 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 366394017279 putative dimer interface [polypeptide binding]; other site 366394017280 [2Fe-2S] cluster binding site [ion binding]; other site 366394017281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394017282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394017283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 366394017284 dimerization interface [polypeptide binding]; other site 366394017285 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 366394017286 classical (c) SDRs; Region: SDR_c; cd05233 366394017287 NAD(P) binding site [chemical binding]; other site 366394017288 active site 366394017289 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 366394017290 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 366394017291 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 366394017292 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 366394017293 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394017294 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 366394017295 Walker A/P-loop; other site 366394017296 ATP binding site [chemical binding]; other site 366394017297 Q-loop/lid; other site 366394017298 ABC transporter signature motif; other site 366394017299 Walker B; other site 366394017300 D-loop; other site 366394017301 H-loop/switch region; other site 366394017302 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 366394017303 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 366394017304 Walker A/P-loop; other site 366394017305 ATP binding site [chemical binding]; other site 366394017306 Q-loop/lid; other site 366394017307 ABC transporter signature motif; other site 366394017308 Walker B; other site 366394017309 D-loop; other site 366394017310 H-loop/switch region; other site 366394017311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394017312 dimer interface [polypeptide binding]; other site 366394017313 conserved gate region; other site 366394017314 putative PBP binding loops; other site 366394017315 ABC-ATPase subunit interface; other site 366394017316 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394017317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394017318 dimer interface [polypeptide binding]; other site 366394017319 conserved gate region; other site 366394017320 putative PBP binding loops; other site 366394017321 ABC-ATPase subunit interface; other site 366394017322 Predicted small integral membrane protein [Function unknown]; Region: COG5477 366394017323 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394017324 xanthine permease; Region: pbuX; TIGR03173 366394017325 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 366394017326 EamA-like transporter family; Region: EamA; pfam00892 366394017327 EamA-like transporter family; Region: EamA; pfam00892 366394017328 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 366394017329 metal binding site 2 [ion binding]; metal-binding site 366394017330 putative DNA binding helix; other site 366394017331 metal binding site 1 [ion binding]; metal-binding site 366394017332 dimer interface [polypeptide binding]; other site 366394017333 structural Zn2+ binding site [ion binding]; other site 366394017334 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 366394017335 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 366394017336 metal binding site [ion binding]; metal-binding site 366394017337 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 366394017338 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 366394017339 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 366394017340 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 366394017341 ABC-ATPase subunit interface; other site 366394017342 dimer interface [polypeptide binding]; other site 366394017343 putative PBP binding regions; other site 366394017344 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 366394017345 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 366394017346 ABC-ATPase subunit interface; other site 366394017347 dimer interface [polypeptide binding]; other site 366394017348 putative PBP binding regions; other site 366394017349 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394017350 putative DNA binding site [nucleotide binding]; other site 366394017351 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 366394017352 putative Zn2+ binding site [ion binding]; other site 366394017353 AsnC family; Region: AsnC_trans_reg; pfam01037 366394017354 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 366394017355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394017356 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 366394017357 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 366394017358 gamma subunit interface [polypeptide binding]; other site 366394017359 epsilon subunit interface [polypeptide binding]; other site 366394017360 LBP interface [polypeptide binding]; other site 366394017361 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 366394017362 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 366394017363 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 366394017364 alpha subunit interaction interface [polypeptide binding]; other site 366394017365 Walker A motif; other site 366394017366 ATP binding site [chemical binding]; other site 366394017367 Walker B motif; other site 366394017368 inhibitor binding site; inhibition site 366394017369 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 366394017370 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 366394017371 core domain interface [polypeptide binding]; other site 366394017372 delta subunit interface [polypeptide binding]; other site 366394017373 epsilon subunit interface [polypeptide binding]; other site 366394017374 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 366394017375 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 366394017376 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 366394017377 beta subunit interaction interface [polypeptide binding]; other site 366394017378 Walker A motif; other site 366394017379 ATP binding site [chemical binding]; other site 366394017380 Walker B motif; other site 366394017381 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 366394017382 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 366394017383 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 366394017384 primosome assembly protein PriA; Validated; Region: PRK05580 366394017385 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 366394017386 ATP binding site [chemical binding]; other site 366394017387 putative Mg++ binding site [ion binding]; other site 366394017388 helicase superfamily c-terminal domain; Region: HELICc; smart00490 366394017389 nucleotide binding region [chemical binding]; other site 366394017390 ATP-binding site [chemical binding]; other site 366394017391 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 366394017392 active site 366394017393 intersubunit interactions; other site 366394017394 catalytic residue [active] 366394017395 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 366394017396 Protein of unknown function (DUF560); Region: DUF560; pfam04575 366394017397 Predicted ATPase [General function prediction only]; Region: COG4637 366394017398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394017399 Walker A/P-loop; other site 366394017400 ATP binding site [chemical binding]; other site 366394017401 Q-loop/lid; other site 366394017402 Putative hemolysin [General function prediction only]; Region: COG3176 366394017403 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 366394017404 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 366394017405 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 366394017406 active site 366394017407 DNA binding site [nucleotide binding] 366394017408 Int/Topo IB signature motif; other site 366394017409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 366394017410 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 366394017411 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 366394017412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 366394017413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 366394017414 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 366394017415 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 366394017416 classical (c) SDRs; Region: SDR_c; cd05233 366394017417 NAD(P) binding site [chemical binding]; other site 366394017418 active site 366394017419 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 366394017420 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 366394017421 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 366394017422 E3 interaction surface; other site 366394017423 lipoyl attachment site [posttranslational modification]; other site 366394017424 e3 binding domain; Region: E3_binding; pfam02817 366394017425 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 366394017426 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 366394017427 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 366394017428 TPP-binding site [chemical binding]; other site 366394017429 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 366394017430 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 366394017431 CoA binding domain; Region: CoA_binding; smart00881 366394017432 CoA-ligase; Region: Ligase_CoA; pfam00549 366394017433 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 366394017434 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 366394017435 CoA-ligase; Region: Ligase_CoA; pfam00549 366394017436 malate dehydrogenase; Reviewed; Region: PRK06223 366394017437 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 366394017438 NAD(P) binding site [chemical binding]; other site 366394017439 dimer interface [polypeptide binding]; other site 366394017440 tetramer (dimer of dimers) interface [polypeptide binding]; other site 366394017441 substrate binding site [chemical binding]; other site 366394017442 Predicted ATPase [General function prediction only]; Region: COG1485 366394017443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394017444 Walker B; other site 366394017445 D-loop; other site 366394017446 H-loop/switch region; other site 366394017447 Protease inhibitor Inh; Region: Inh; pfam02974 366394017448 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394017449 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394017450 Walker A/P-loop; other site 366394017451 ATP binding site [chemical binding]; other site 366394017452 Q-loop/lid; other site 366394017453 ABC transporter signature motif; other site 366394017454 Walker B; other site 366394017455 D-loop; other site 366394017456 H-loop/switch region; other site 366394017457 TOBE domain; Region: TOBE; pfam03459 366394017458 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394017459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394017460 dimer interface [polypeptide binding]; other site 366394017461 conserved gate region; other site 366394017462 putative PBP binding loops; other site 366394017463 ABC-ATPase subunit interface; other site 366394017464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394017465 dimer interface [polypeptide binding]; other site 366394017466 conserved gate region; other site 366394017467 putative PBP binding loops; other site 366394017468 ABC-ATPase subunit interface; other site 366394017469 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394017470 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394017471 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 366394017472 putative Zn2+ binding site [ion binding]; other site 366394017473 putative DNA binding site [nucleotide binding]; other site 366394017474 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 366394017475 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 366394017476 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394017477 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394017478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828 366394017479 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 366394017480 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 366394017481 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 366394017482 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 366394017483 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 366394017484 L-aspartate oxidase; Provisional; Region: PRK06175 366394017485 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 366394017486 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 366394017487 putative SdhC subunit interface [polypeptide binding]; other site 366394017488 putative proximal heme binding site [chemical binding]; other site 366394017489 putative Iron-sulfur protein interface [polypeptide binding]; other site 366394017490 putative proximal quinone binding site; other site 366394017491 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 366394017492 Iron-sulfur protein interface; other site 366394017493 proximal quinone binding site [chemical binding]; other site 366394017494 SdhD (CybS) interface [polypeptide binding]; other site 366394017495 proximal heme binding site [chemical binding]; other site 366394017496 Predicted methyltransferase [General function prediction only]; Region: COG3897 366394017497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 366394017498 Uncharacterized conserved protein [Function unknown]; Region: COG2947 366394017499 YciI-like protein; Reviewed; Region: PRK12865 366394017500 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 366394017501 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 366394017502 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 366394017503 UGMP family protein; Validated; Region: PRK09604 366394017504 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 366394017505 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 366394017506 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 366394017507 domain interfaces; other site 366394017508 active site 366394017509 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 366394017510 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 366394017511 active site 366394017512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 366394017513 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 366394017514 HemY protein N-terminus; Region: HemY_N; pfam07219 366394017515 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 366394017516 putative metal binding site [ion binding]; other site 366394017517 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 366394017518 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 366394017519 catalytic triad [active] 366394017520 H+ Antiporter protein; Region: 2A0121; TIGR00900 366394017521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394017522 putative substrate translocation pore; other site 366394017523 YGGT family; Region: YGGT; pfam02325 366394017524 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 366394017525 dimer interface [polypeptide binding]; other site 366394017526 substrate binding site [chemical binding]; other site 366394017527 metal binding sites [ion binding]; metal-binding site 366394017528 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 366394017529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394017530 Coenzyme A binding pocket [chemical binding]; other site 366394017531 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 366394017532 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 366394017533 G1 box; other site 366394017534 putative GEF interaction site [polypeptide binding]; other site 366394017535 GTP/Mg2+ binding site [chemical binding]; other site 366394017536 Switch I region; other site 366394017537 G2 box; other site 366394017538 G3 box; other site 366394017539 Switch II region; other site 366394017540 G4 box; other site 366394017541 G5 box; other site 366394017542 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 366394017543 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 366394017544 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 366394017545 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 366394017546 putative active site [active] 366394017547 putative metal binding site [ion binding]; other site 366394017548 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394017549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394017550 DNA-binding site [nucleotide binding]; DNA binding site 366394017551 FCD domain; Region: FCD; pfam07729 366394017552 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 366394017553 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394017554 substrate binding pocket [chemical binding]; other site 366394017555 membrane-bound complex binding site; other site 366394017556 hinge residues; other site 366394017557 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 366394017558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394017559 dimer interface [polypeptide binding]; other site 366394017560 conserved gate region; other site 366394017561 putative PBP binding loops; other site 366394017562 ABC-ATPase subunit interface; other site 366394017563 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 366394017564 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 366394017565 Walker A/P-loop; other site 366394017566 ATP binding site [chemical binding]; other site 366394017567 Q-loop/lid; other site 366394017568 ABC transporter signature motif; other site 366394017569 Walker B; other site 366394017570 D-loop; other site 366394017571 H-loop/switch region; other site 366394017572 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 366394017573 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 366394017574 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 366394017575 catalytic residue [active] 366394017576 dihydropyrimidinase; Provisional; Region: PRK13404 366394017577 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 366394017578 tetramer interface [polypeptide binding]; other site 366394017579 active site 366394017580 amidase; Provisional; Region: PRK07056 366394017581 amidase; Validated; Region: PRK05962 366394017582 Phytochelatin synthase; Region: Phytochelatin; pfam05023 366394017583 Isochorismatase family; Region: Isochorismatase; pfam00857 366394017584 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 366394017585 catalytic triad [active] 366394017586 conserved cis-peptide bond; other site 366394017587 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 366394017588 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 366394017589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 366394017590 Putative glucoamylase; Region: Glycoamylase; pfam10091 366394017591 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 366394017592 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 366394017593 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 366394017594 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 366394017595 catalytic core [active] 366394017596 putative phosphoketolase; Provisional; Region: PRK05261 366394017597 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 366394017598 TPP-binding site; other site 366394017599 XFP C-terminal domain; Region: XFP_C; pfam09363 366394017600 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 366394017601 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 366394017602 NAD binding site [chemical binding]; other site 366394017603 substrate binding site [chemical binding]; other site 366394017604 catalytic Zn binding site [ion binding]; other site 366394017605 tetramer interface [polypeptide binding]; other site 366394017606 structural Zn binding site [ion binding]; other site 366394017607 FOG: CBS domain [General function prediction only]; Region: COG0517 366394017608 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 366394017609 BON domain; Region: BON; pfam04972 366394017610 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 366394017611 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 366394017612 Mechanosensitive ion channel; Region: MS_channel; pfam00924 366394017613 Uncharacterized conserved protein [Function unknown]; Region: COG2966 366394017614 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 366394017615 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 366394017616 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 366394017617 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 366394017618 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 366394017619 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 366394017620 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 366394017621 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 366394017622 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 366394017623 GTPase CgtA; Reviewed; Region: obgE; PRK12299 366394017624 GTP1/OBG; Region: GTP1_OBG; pfam01018 366394017625 Obg GTPase; Region: Obg; cd01898 366394017626 G1 box; other site 366394017627 GTP/Mg2+ binding site [chemical binding]; other site 366394017628 Switch I region; other site 366394017629 G2 box; other site 366394017630 G3 box; other site 366394017631 Switch II region; other site 366394017632 G4 box; other site 366394017633 G5 box; other site 366394017634 gamma-glutamyl kinase; Provisional; Region: PRK05429 366394017635 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 366394017636 nucleotide binding site [chemical binding]; other site 366394017637 homotetrameric interface [polypeptide binding]; other site 366394017638 putative phosphate binding site [ion binding]; other site 366394017639 putative allosteric binding site; other site 366394017640 PUA domain; Region: PUA; pfam01472 366394017641 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 366394017642 putative catalytic cysteine [active] 366394017643 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 366394017644 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 366394017645 active site 366394017646 (T/H)XGH motif; other site 366394017647 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 366394017648 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 366394017649 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 366394017650 Peptidase family M23; Region: Peptidase_M23; pfam01551 366394017651 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 366394017652 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 366394017653 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 366394017654 protein binding site [polypeptide binding]; other site 366394017655 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 366394017656 Catalytic dyad [active] 366394017657 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 366394017658 NodB motif; other site 366394017659 putative active site [active] 366394017660 putative catalytic site [active] 366394017661 Zn binding site [ion binding]; other site 366394017662 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 366394017663 putative active site [active] 366394017664 Ap4A binding site [chemical binding]; other site 366394017665 nudix motif; other site 366394017666 putative metal binding site [ion binding]; other site 366394017667 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 366394017668 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 366394017669 heme binding site [chemical binding]; other site 366394017670 ferroxidase pore; other site 366394017671 ferroxidase diiron center [ion binding]; other site 366394017672 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 366394017673 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 366394017674 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 366394017675 putative active site [active] 366394017676 putative PHP Thumb interface [polypeptide binding]; other site 366394017677 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 366394017678 generic binding surface II; other site 366394017679 generic binding surface I; other site 366394017680 DNA Polymerase Y-family; Region: PolY_like; cd03468 366394017681 active site 366394017682 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 366394017683 DNA binding site [nucleotide binding] 366394017684 Uncharacterized conserved protein [Function unknown]; Region: COG4544 366394017685 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 366394017686 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 366394017687 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 366394017688 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 366394017689 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 366394017690 substrate binding site [chemical binding]; other site 366394017691 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 366394017692 homotrimer interaction site [polypeptide binding]; other site 366394017693 putative active site [active] 366394017694 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 366394017695 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 366394017696 proposed active site lysine [active] 366394017697 conserved cys residue [active] 366394017698 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 366394017699 active site 366394017700 catalytic residues [active] 366394017701 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394017702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394017703 NAD(P) binding site [chemical binding]; other site 366394017704 active site 366394017705 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 366394017706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394017707 NAD(P) binding site [chemical binding]; other site 366394017708 active site 366394017709 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 366394017710 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 366394017711 nucleotide binding site [chemical binding]; other site 366394017712 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 366394017713 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 366394017714 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 366394017715 E3 interaction surface; other site 366394017716 lipoyl attachment site [posttranslational modification]; other site 366394017717 e3 binding domain; Region: E3_binding; pfam02817 366394017718 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 366394017719 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 366394017720 alpha subunit interface [polypeptide binding]; other site 366394017721 TPP binding site [chemical binding]; other site 366394017722 heterodimer interface [polypeptide binding]; other site 366394017723 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 366394017724 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 366394017725 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 366394017726 tetramer interface [polypeptide binding]; other site 366394017727 TPP-binding site [chemical binding]; other site 366394017728 heterodimer interface [polypeptide binding]; other site 366394017729 phosphorylation loop region [posttranslational modification] 366394017730 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394017731 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394017732 TM-ABC transporter signature motif; other site 366394017733 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394017734 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394017735 Walker A/P-loop; other site 366394017736 ATP binding site [chemical binding]; other site 366394017737 Q-loop/lid; other site 366394017738 ABC transporter signature motif; other site 366394017739 Walker B; other site 366394017740 D-loop; other site 366394017741 H-loop/switch region; other site 366394017742 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394017743 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394017744 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 366394017745 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 366394017746 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 366394017747 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 366394017748 putative deacylase active site [active] 366394017749 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 366394017750 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 366394017751 catalytic residues [active] 366394017752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394017753 binding surface 366394017754 TPR motif; other site 366394017755 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 366394017756 Uncharacterized conserved protein [Function unknown]; Region: COG2835 366394017757 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 366394017758 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 366394017759 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 366394017760 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 366394017761 active site 366394017762 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 366394017763 catalytic triad [active] 366394017764 dimer interface [polypeptide binding]; other site 366394017765 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 366394017766 Nitrogen regulatory protein P-II; Region: P-II; smart00938 366394017767 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 366394017768 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 366394017769 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 366394017770 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 366394017771 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 366394017772 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 366394017773 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 366394017774 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 366394017775 putative catalytic site [active] 366394017776 putative phosphate binding site [ion binding]; other site 366394017777 active site 366394017778 metal binding site A [ion binding]; metal-binding site 366394017779 DNA binding site [nucleotide binding] 366394017780 putative AP binding site [nucleotide binding]; other site 366394017781 putative metal binding site B [ion binding]; other site 366394017782 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 366394017783 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 366394017784 ligand binding site [chemical binding]; other site 366394017785 flexible hinge region; other site 366394017786 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 366394017787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394017788 active site 366394017789 phosphorylation site [posttranslational modification] 366394017790 intermolecular recognition site; other site 366394017791 dimerization interface [polypeptide binding]; other site 366394017792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394017793 DNA binding site [nucleotide binding] 366394017794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 366394017795 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 366394017796 catalytic core [active] 366394017797 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 366394017798 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 366394017799 substrate binding site [chemical binding]; other site 366394017800 ligand binding site [chemical binding]; other site 366394017801 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 366394017802 MarR family; Region: MarR; pfam01047 366394017803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394017804 Major Facilitator Superfamily; Region: MFS_1; pfam07690 366394017805 putative substrate translocation pore; other site 366394017806 argininosuccinate synthase; Provisional; Region: PRK13820 366394017807 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 366394017808 ANP binding site [chemical binding]; other site 366394017809 Substrate Binding Site II [chemical binding]; other site 366394017810 Substrate Binding Site I [chemical binding]; other site 366394017811 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 366394017812 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 366394017813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394017814 Walker A/P-loop; other site 366394017815 ATP binding site [chemical binding]; other site 366394017816 Q-loop/lid; other site 366394017817 ABC transporter signature motif; other site 366394017818 Walker B; other site 366394017819 D-loop; other site 366394017820 H-loop/switch region; other site 366394017821 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394017822 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 366394017823 TM-ABC transporter signature motif; other site 366394017824 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 366394017825 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 366394017826 zinc binding site [ion binding]; other site 366394017827 putative ligand binding site [chemical binding]; other site 366394017828 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 366394017829 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 366394017830 FeS/SAM binding site; other site 366394017831 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 366394017832 Uncharacterized conserved protein [Function unknown]; Region: COG3339 366394017833 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 366394017834 aromatic arch; other site 366394017835 DCoH dimer interaction site [polypeptide binding]; other site 366394017836 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 366394017837 DCoH tetramer interaction site [polypeptide binding]; other site 366394017838 substrate binding site [chemical binding]; other site 366394017839 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 366394017840 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 366394017841 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 366394017842 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 366394017843 active site 366394017844 catalytic triad [active] 366394017845 oxyanion hole [active] 366394017846 switch loop; other site 366394017847 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 366394017848 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 366394017849 Walker A/P-loop; other site 366394017850 ATP binding site [chemical binding]; other site 366394017851 Q-loop/lid; other site 366394017852 ABC transporter signature motif; other site 366394017853 Walker B; other site 366394017854 D-loop; other site 366394017855 H-loop/switch region; other site 366394017856 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 366394017857 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 366394017858 FtsX-like permease family; Region: FtsX; pfam02687 366394017859 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 366394017860 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 366394017861 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 366394017862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394017863 Coenzyme A binding pocket [chemical binding]; other site 366394017864 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 366394017865 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 366394017866 oligomer interface [polypeptide binding]; other site 366394017867 active site residues [active] 366394017868 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 366394017869 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394017870 dimerization interface [polypeptide binding]; other site 366394017871 putative DNA binding site [nucleotide binding]; other site 366394017872 putative Zn2+ binding site [ion binding]; other site 366394017873 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 366394017874 Uncharacterized secreted protein [Function unknown]; Region: COG5429 366394017875 aconitate hydratase; Validated; Region: PRK09277 366394017876 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 366394017877 substrate binding site [chemical binding]; other site 366394017878 ligand binding site [chemical binding]; other site 366394017879 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 366394017880 substrate binding site [chemical binding]; other site 366394017881 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 366394017882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394017883 Walker A/P-loop; other site 366394017884 ATP binding site [chemical binding]; other site 366394017885 Q-loop/lid; other site 366394017886 ABC transporter signature motif; other site 366394017887 Walker B; other site 366394017888 D-loop; other site 366394017889 H-loop/switch region; other site 366394017890 heme exporter protein CcmB; Region: ccmB; TIGR01190 366394017891 heme exporter protein CcmC; Region: ccmC; TIGR01191 366394017892 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 366394017893 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 366394017894 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 366394017895 catalytic residues [active] 366394017896 central insert; other site 366394017897 hypothetical protein; Provisional; Region: PRK00944 366394017898 intracellular septation protein A; Reviewed; Region: PRK00259 366394017899 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 366394017900 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 366394017901 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 366394017902 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 366394017903 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 366394017904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 366394017905 FeS/SAM binding site; other site 366394017906 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 366394017907 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 366394017908 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 366394017909 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 366394017910 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 366394017911 signal recognition particle protein; Provisional; Region: PRK10867 366394017912 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 366394017913 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 366394017914 P loop; other site 366394017915 GTP binding site [chemical binding]; other site 366394017916 Signal peptide binding domain; Region: SRP_SPB; pfam02978 366394017917 chorismate mutase; Provisional; Region: PRK09239 366394017918 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 366394017919 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 366394017920 RimM N-terminal domain; Region: RimM; pfam01782 366394017921 PRC-barrel domain; Region: PRC; pfam05239 366394017922 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 366394017923 hypothetical protein; Provisional; Region: PRK10621 366394017924 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 366394017925 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 366394017926 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 366394017927 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394017928 substrate binding pocket [chemical binding]; other site 366394017929 membrane-bound complex binding site; other site 366394017930 hinge residues; other site 366394017931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394017932 dimer interface [polypeptide binding]; other site 366394017933 conserved gate region; other site 366394017934 putative PBP binding loops; other site 366394017935 ABC-ATPase subunit interface; other site 366394017936 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 366394017937 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 366394017938 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 366394017939 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 366394017940 Thiamine pyrophosphokinase; Region: TPK; cd07995 366394017941 active site 366394017942 dimerization interface [polypeptide binding]; other site 366394017943 thiamine binding site [chemical binding]; other site 366394017944 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 366394017945 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 366394017946 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 366394017947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394017948 dimer interface [polypeptide binding]; other site 366394017949 conserved gate region; other site 366394017950 putative PBP binding loops; other site 366394017951 ABC-ATPase subunit interface; other site 366394017952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394017953 dimer interface [polypeptide binding]; other site 366394017954 conserved gate region; other site 366394017955 putative PBP binding loops; other site 366394017956 ABC-ATPase subunit interface; other site 366394017957 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 366394017958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394017959 Walker A/P-loop; other site 366394017960 ATP binding site [chemical binding]; other site 366394017961 Q-loop/lid; other site 366394017962 ABC transporter signature motif; other site 366394017963 Walker B; other site 366394017964 D-loop; other site 366394017965 H-loop/switch region; other site 366394017966 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 366394017967 Peptidase family M48; Region: Peptidase_M48; pfam01435 366394017968 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 366394017969 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 366394017970 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 366394017971 DNA binding residues [nucleotide binding] 366394017972 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 366394017973 Ferredoxin [Energy production and conversion]; Region: COG1146 366394017974 4Fe-4S binding domain; Region: Fer4; pfam00037 366394017975 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 366394017976 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 366394017977 RNA binding surface [nucleotide binding]; other site 366394017978 DEAD/DEAH box helicase; Region: DEAD; pfam00270 366394017979 ATP binding site [chemical binding]; other site 366394017980 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 366394017981 putative Mg++ binding site [ion binding]; other site 366394017982 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 366394017983 nucleotide binding region [chemical binding]; other site 366394017984 ATP-binding site [chemical binding]; other site 366394017985 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 366394017986 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 366394017987 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 366394017988 NAD(P) binding site [chemical binding]; other site 366394017989 homotetramer interface [polypeptide binding]; other site 366394017990 homodimer interface [polypeptide binding]; other site 366394017991 active site 366394017992 putative acyltransferase; Provisional; Region: PRK05790 366394017993 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 366394017994 dimer interface [polypeptide binding]; other site 366394017995 active site 366394017996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 366394017997 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 366394017998 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 366394017999 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 366394018000 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 366394018001 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394018002 putative C-terminal domain interface [polypeptide binding]; other site 366394018003 putative GSH binding site (G-site) [chemical binding]; other site 366394018004 putative dimer interface [polypeptide binding]; other site 366394018005 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 366394018006 putative N-terminal domain interface [polypeptide binding]; other site 366394018007 putative dimer interface [polypeptide binding]; other site 366394018008 putative substrate binding pocket (H-site) [chemical binding]; other site 366394018009 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 366394018010 Transglycosylase; Region: Transgly; pfam00912 366394018011 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 366394018012 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 366394018013 substrate binding pocket [chemical binding]; other site 366394018014 chain length determination region; other site 366394018015 substrate-Mg2+ binding site; other site 366394018016 catalytic residues [active] 366394018017 aspartate-rich region 1; other site 366394018018 active site lid residues [active] 366394018019 aspartate-rich region 2; other site 366394018020 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 366394018021 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394018022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394018023 homodimer interface [polypeptide binding]; other site 366394018024 catalytic residue [active] 366394018025 short chain dehydrogenase; Provisional; Region: PRK06114 366394018026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394018027 NAD(P) binding site [chemical binding]; other site 366394018028 active site 366394018029 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394018030 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394018031 Walker A/P-loop; other site 366394018032 ATP binding site [chemical binding]; other site 366394018033 Q-loop/lid; other site 366394018034 ABC transporter signature motif; other site 366394018035 Walker B; other site 366394018036 D-loop; other site 366394018037 H-loop/switch region; other site 366394018038 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394018039 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 366394018040 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 366394018041 ligand binding site [chemical binding]; other site 366394018042 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394018043 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394018044 TM-ABC transporter signature motif; other site 366394018045 transketolase; Reviewed; Region: PRK05899 366394018046 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 366394018047 TPP-binding site [chemical binding]; other site 366394018048 dimer interface [polypeptide binding]; other site 366394018049 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 366394018050 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 366394018051 PYR/PP interface [polypeptide binding]; other site 366394018052 dimer interface [polypeptide binding]; other site 366394018053 TPP binding site [chemical binding]; other site 366394018054 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 366394018055 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 366394018056 N- and C-terminal domain interface [polypeptide binding]; other site 366394018057 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 366394018058 active site 366394018059 MgATP binding site [chemical binding]; other site 366394018060 catalytic site [active] 366394018061 metal binding site [ion binding]; metal-binding site 366394018062 putative homotetramer interface [polypeptide binding]; other site 366394018063 putative homodimer interface [polypeptide binding]; other site 366394018064 glycerol binding site [chemical binding]; other site 366394018065 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 366394018066 MarR family; Region: MarR_2; cl17246 366394018067 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 366394018068 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394018069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394018070 NAD(P) binding site [chemical binding]; other site 366394018071 active site 366394018072 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 366394018073 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 366394018074 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 366394018075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394018076 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 366394018077 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 366394018078 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 366394018079 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 366394018080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394018081 substrate binding pocket [chemical binding]; other site 366394018082 membrane-bound complex binding site; other site 366394018083 hinge residues; other site 366394018084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394018085 dimer interface [polypeptide binding]; other site 366394018086 conserved gate region; other site 366394018087 putative PBP binding loops; other site 366394018088 ABC-ATPase subunit interface; other site 366394018089 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 366394018090 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 366394018091 Walker A/P-loop; other site 366394018092 ATP binding site [chemical binding]; other site 366394018093 Q-loop/lid; other site 366394018094 ABC transporter signature motif; other site 366394018095 Walker B; other site 366394018096 D-loop; other site 366394018097 H-loop/switch region; other site 366394018098 pyruvate carboxylase; Reviewed; Region: PRK12999 366394018099 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 366394018100 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 366394018101 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 366394018102 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 366394018103 active site 366394018104 catalytic residues [active] 366394018105 metal binding site [ion binding]; metal-binding site 366394018106 homodimer binding site [polypeptide binding]; other site 366394018107 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 366394018108 carboxyltransferase (CT) interaction site; other site 366394018109 biotinylation site [posttranslational modification]; other site 366394018110 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 366394018111 Autoinducer binding domain; Region: Autoind_bind; pfam03472 366394018112 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 366394018113 DNA binding residues [nucleotide binding] 366394018114 dimerization interface [polypeptide binding]; other site 366394018115 glucan exporter ATP-binding protein; Region: chvA; TIGR01192 366394018116 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 366394018117 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 366394018118 Walker A/P-loop; other site 366394018119 ATP binding site [chemical binding]; other site 366394018120 Q-loop/lid; other site 366394018121 ABC transporter signature motif; other site 366394018122 Walker B; other site 366394018123 D-loop; other site 366394018124 H-loop/switch region; other site 366394018125 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394018126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394018127 DNA-binding site [nucleotide binding]; DNA binding site 366394018128 FCD domain; Region: FCD; pfam07729 366394018129 Sulfatase; Region: Sulfatase; cl17466 366394018130 choline-sulfatase; Region: chol_sulfatase; TIGR03417 366394018131 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 366394018132 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 366394018133 membrane-bound complex binding site; other site 366394018134 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 366394018135 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 366394018136 Walker A/P-loop; other site 366394018137 ATP binding site [chemical binding]; other site 366394018138 Q-loop/lid; other site 366394018139 ABC transporter signature motif; other site 366394018140 Walker B; other site 366394018141 D-loop; other site 366394018142 H-loop/switch region; other site 366394018143 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 366394018144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394018145 dimer interface [polypeptide binding]; other site 366394018146 conserved gate region; other site 366394018147 putative PBP binding loops; other site 366394018148 ABC-ATPase subunit interface; other site 366394018149 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 366394018150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394018151 dimer interface [polypeptide binding]; other site 366394018152 conserved gate region; other site 366394018153 putative PBP binding loops; other site 366394018154 ABC-ATPase subunit interface; other site 366394018155 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394018156 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394018157 active site 366394018158 catalytic tetrad [active] 366394018159 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 366394018160 Amidohydrolase; Region: Amidohydro_2; pfam04909 366394018161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645 366394018162 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 366394018163 Putative glucoamylase; Region: Glycoamylase; pfam10091 366394018164 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 366394018165 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 366394018166 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 366394018167 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 366394018168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394018169 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 366394018170 dimerization interface [polypeptide binding]; other site 366394018171 substrate binding pocket [chemical binding]; other site 366394018172 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 366394018173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 366394018174 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 366394018175 FAD binding domain; Region: FAD_binding_4; pfam01565 366394018176 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 366394018177 aldehyde dehydrogenase family 7 member; Region: PLN02315 366394018178 tetrameric interface [polypeptide binding]; other site 366394018179 NAD binding site [chemical binding]; other site 366394018180 catalytic residues [active] 366394018181 aspartate aminotransferase; Provisional; Region: PRK05764 366394018182 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394018183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394018184 homodimer interface [polypeptide binding]; other site 366394018185 catalytic residue [active] 366394018186 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394018187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394018188 sequence-specific DNA binding site [nucleotide binding]; other site 366394018189 salt bridge; other site 366394018190 Cupin domain; Region: Cupin_2; pfam07883 366394018191 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 366394018192 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 366394018193 inhibitor-cofactor binding pocket; inhibition site 366394018194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394018195 catalytic residue [active] 366394018196 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 366394018197 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 366394018198 MOFRL family; Region: MOFRL; pfam05161 366394018199 choline dehydrogenase; Validated; Region: PRK02106 366394018200 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 366394018201 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 366394018202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394018203 NAD(P) binding site [chemical binding]; other site 366394018204 active site 366394018205 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 366394018206 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 366394018207 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394018208 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394018209 Walker A/P-loop; other site 366394018210 ATP binding site [chemical binding]; other site 366394018211 Q-loop/lid; other site 366394018212 ABC transporter signature motif; other site 366394018213 Walker B; other site 366394018214 D-loop; other site 366394018215 H-loop/switch region; other site 366394018216 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394018217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394018218 dimer interface [polypeptide binding]; other site 366394018219 conserved gate region; other site 366394018220 putative PBP binding loops; other site 366394018221 ABC-ATPase subunit interface; other site 366394018222 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394018223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394018224 dimer interface [polypeptide binding]; other site 366394018225 conserved gate region; other site 366394018226 putative PBP binding loops; other site 366394018227 ABC-ATPase subunit interface; other site 366394018228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394018229 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 366394018230 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 366394018231 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 366394018232 NAD(P) binding site [chemical binding]; other site 366394018233 catalytic residues [active] 366394018234 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 366394018235 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 366394018236 substrate binding site [chemical binding]; other site 366394018237 oxyanion hole (OAH) forming residues; other site 366394018238 trimer interface [polypeptide binding]; other site 366394018239 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 366394018240 Coenzyme A transferase; Region: CoA_trans; smart00882 366394018241 Coenzyme A transferase; Region: CoA_trans; cl17247 366394018242 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394018243 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394018244 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394018245 Transcriptional regulators [Transcription]; Region: PurR; COG1609 366394018246 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 366394018247 DNA binding site [nucleotide binding] 366394018248 domain linker motif; other site 366394018249 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 366394018250 putative dimerization interface [polypeptide binding]; other site 366394018251 putative ligand binding site [chemical binding]; other site 366394018252 Protein of unknown function (DUF993); Region: DUF993; pfam06187 366394018253 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 366394018254 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 366394018255 active site 366394018256 Zn binding site [ion binding]; other site 366394018257 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 366394018258 tartrate dehydrogenase; Region: TTC; TIGR02089 366394018259 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 366394018260 active site 366394018261 metabolite-proton symporter; Region: 2A0106; TIGR00883 366394018262 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 366394018263 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 366394018264 Transglycosylase SLT domain; Region: SLT_2; pfam13406 366394018265 murein hydrolase B; Provisional; Region: PRK10760; cl17906 366394018266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 366394018267 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 366394018268 active site clefts [active] 366394018269 zinc binding site [ion binding]; other site 366394018270 dimer interface [polypeptide binding]; other site 366394018271 pyridoxamine kinase; Validated; Region: PRK05756 366394018272 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 366394018273 pyridoxal binding site [chemical binding]; other site 366394018274 dimer interface [polypeptide binding]; other site 366394018275 ATP binding site [chemical binding]; other site 366394018276 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 366394018277 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 366394018278 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 366394018279 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 366394018280 purine monophosphate binding site [chemical binding]; other site 366394018281 dimer interface [polypeptide binding]; other site 366394018282 putative catalytic residues [active] 366394018283 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 366394018284 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 366394018285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 366394018286 NusB family; Region: NusB; pfam01029 366394018287 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 366394018288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394018289 S-adenosylmethionine binding site [chemical binding]; other site 366394018290 heat shock protein HtpX; Provisional; Region: PRK01345 366394018291 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 366394018292 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 366394018293 acetyl-CoA synthetase; Provisional; Region: PRK00174 366394018294 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 366394018295 active site 366394018296 CoA binding site [chemical binding]; other site 366394018297 acyl-activating enzyme (AAE) consensus motif; other site 366394018298 AMP binding site [chemical binding]; other site 366394018299 acetate binding site [chemical binding]; other site 366394018300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 366394018301 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 366394018302 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 366394018303 acyl-activating enzyme (AAE) consensus motif; other site 366394018304 AMP binding site [chemical binding]; other site 366394018305 active site 366394018306 CoA binding site [chemical binding]; other site 366394018307 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 366394018308 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 366394018309 catalytic residue [active] 366394018310 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 366394018311 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 366394018312 HIGH motif; other site 366394018313 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 366394018314 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 366394018315 active site 366394018316 KMSKS motif; other site 366394018317 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 366394018318 tRNA binding surface [nucleotide binding]; other site 366394018319 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 366394018320 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 366394018321 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 366394018322 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 366394018323 ParB-like nuclease domain; Region: ParBc; pfam02195 366394018324 KorB domain; Region: KorB; pfam08535 366394018325 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 366394018326 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 366394018327 P-loop; other site 366394018328 Magnesium ion binding site [ion binding]; other site 366394018329 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 366394018330 Magnesium ion binding site [ion binding]; other site 366394018331 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 366394018332 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 366394018333 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 366394018334 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 366394018335 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 366394018336 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 366394018337 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 366394018338 trmE is a tRNA modification GTPase; Region: trmE; cd04164 366394018339 G1 box; other site 366394018340 GTP/Mg2+ binding site [chemical binding]; other site 366394018341 Switch I region; other site 366394018342 G2 box; other site 366394018343 Switch II region; other site 366394018344 G3 box; other site 366394018345 G4 box; other site 366394018346 G5 box; other site 366394018347 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 366394018348 transcription termination factor Rho; Provisional; Region: rho; PRK09376 366394018349 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 366394018350 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 366394018351 RNA binding site [nucleotide binding]; other site 366394018352 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 366394018353 multimer interface [polypeptide binding]; other site 366394018354 Walker A motif; other site 366394018355 ATP binding site [chemical binding]; other site 366394018356 Walker B motif; other site 366394018357 Predicted membrane protein [Function unknown]; Region: COG1981 366394018358 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 366394018359 substrate binding site [chemical binding]; other site 366394018360 active site 366394018361 PEP synthetase regulatory protein; Provisional; Region: PRK05339 366394018362 Maf-like protein; Reviewed; Region: PRK00078 366394018363 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 366394018364 active site 366394018365 dimer interface [polypeptide binding]; other site 366394018366 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 366394018367 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 366394018368 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 366394018369 shikimate binding site; other site 366394018370 NAD(P) binding site [chemical binding]; other site 366394018371 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 366394018372 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 366394018373 CoA-binding site [chemical binding]; other site 366394018374 ATP-binding [chemical binding]; other site 366394018375 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 366394018376 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 366394018377 active site 366394018378 catalytic site [active] 366394018379 substrate binding site [chemical binding]; other site 366394018380 Preprotein translocase subunit SecB [Intracellular trafficking and secretion]; Region: SecB; COG1952 366394018381 SecA binding site; other site 366394018382 Preprotein binding site; other site 366394018383 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 366394018384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 366394018385 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 366394018386 MltA specific insert domain; Region: MltA; smart00925 366394018387 3D domain; Region: 3D; pfam06725 366394018388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 366394018389 Smr domain; Region: Smr; pfam01713 366394018390 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394018391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394018392 non-specific DNA binding site [nucleotide binding]; other site 366394018393 salt bridge; other site 366394018394 sequence-specific DNA binding site [nucleotide binding]; other site 366394018395 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 366394018396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394018397 Mg2+ binding site [ion binding]; other site 366394018398 G-X-G motif; other site 366394018399 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 366394018400 anchoring element; other site 366394018401 dimer interface [polypeptide binding]; other site 366394018402 ATP binding site [chemical binding]; other site 366394018403 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 366394018404 active site 366394018405 putative metal-binding site [ion binding]; other site 366394018406 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 366394018407 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 366394018408 putative FMN binding site [chemical binding]; other site 366394018409 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 366394018410 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 366394018411 tetramerization interface [polypeptide binding]; other site 366394018412 NAD(P) binding site [chemical binding]; other site 366394018413 catalytic residues [active] 366394018414 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 366394018415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 366394018416 DNA-binding site [nucleotide binding]; DNA binding site 366394018417 Transcriptional regulators [Transcription]; Region: GntR; COG1802 366394018418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 366394018419 DNA-binding site [nucleotide binding]; DNA binding site 366394018420 FCD domain; Region: FCD; pfam07729 366394018421 galactarate dehydratase; Region: galactar-dH20; TIGR03248 366394018422 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 366394018423 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 366394018424 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394018425 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394018426 active site 366394018427 catalytic tetrad [active] 366394018428 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 366394018429 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 366394018430 putative ligand binding site [chemical binding]; other site 366394018431 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 366394018432 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394018433 Walker A/P-loop; other site 366394018434 ATP binding site [chemical binding]; other site 366394018435 Q-loop/lid; other site 366394018436 ABC transporter signature motif; other site 366394018437 Walker B; other site 366394018438 D-loop; other site 366394018439 H-loop/switch region; other site 366394018440 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394018441 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394018442 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 366394018443 TM-ABC transporter signature motif; other site 366394018444 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 366394018445 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 366394018446 putative NAD(P) binding site [chemical binding]; other site 366394018447 catalytic Zn binding site [ion binding]; other site 366394018448 structural Zn binding site [ion binding]; other site 366394018449 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 366394018450 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 366394018451 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 366394018452 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 366394018453 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 366394018454 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 366394018455 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 366394018456 active site 366394018457 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 366394018458 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 366394018459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394018460 catalytic residue [active] 366394018461 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 366394018462 substrate binding site [chemical binding]; other site 366394018463 active site 366394018464 catalytic residues [active] 366394018465 heterodimer interface [polypeptide binding]; other site 366394018466 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 366394018467 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 366394018468 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 366394018469 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 366394018470 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 366394018471 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 366394018472 catalytic residues [active] 366394018473 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 366394018474 Family description; Region: UvrD_C_2; pfam13538 366394018475 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 366394018476 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 366394018477 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 366394018478 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 366394018479 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 366394018480 Substrate binding site; other site 366394018481 metal-binding site 366394018482 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 366394018483 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 366394018484 Phosphotransferase enzyme family; Region: APH; pfam01636 366394018485 PAS fold; Region: PAS_7; pfam12860 366394018486 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 366394018487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394018488 dimer interface [polypeptide binding]; other site 366394018489 phosphorylation site [posttranslational modification] 366394018490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394018491 ATP binding site [chemical binding]; other site 366394018492 Mg2+ binding site [ion binding]; other site 366394018493 G-X-G motif; other site 366394018494 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 366394018495 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 366394018496 homotetramer interface [polypeptide binding]; other site 366394018497 ligand binding site [chemical binding]; other site 366394018498 catalytic site [active] 366394018499 NAD binding site [chemical binding]; other site 366394018500 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 366394018501 dimerization domain swap beta strand [polypeptide binding]; other site 366394018502 regulatory protein interface [polypeptide binding]; other site 366394018503 active site 366394018504 regulatory phosphorylation site [posttranslational modification]; other site 366394018505 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 366394018506 active pocket/dimerization site; other site 366394018507 active site 366394018508 phosphorylation site [posttranslational modification] 366394018509 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 366394018510 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 366394018511 Hpr binding site; other site 366394018512 active site 366394018513 homohexamer subunit interaction site [polypeptide binding]; other site 366394018514 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 366394018515 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 366394018516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394018517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 366394018518 dimerization interface [polypeptide binding]; other site 366394018519 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394018520 dimer interface [polypeptide binding]; other site 366394018521 phosphorylation site [posttranslational modification] 366394018522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394018523 ATP binding site [chemical binding]; other site 366394018524 Mg2+ binding site [ion binding]; other site 366394018525 G-X-G motif; other site 366394018526 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 366394018527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394018528 active site 366394018529 phosphorylation site [posttranslational modification] 366394018530 intermolecular recognition site; other site 366394018531 dimerization interface [polypeptide binding]; other site 366394018532 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394018533 DNA binding site [nucleotide binding] 366394018534 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 366394018535 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 366394018536 active site 366394018537 substrate-binding site [chemical binding]; other site 366394018538 metal-binding site [ion binding] 366394018539 ATP binding site [chemical binding]; other site 366394018540 hypothetical protein; Provisional; Region: PRK09256 366394018541 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 366394018542 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 366394018543 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 366394018544 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 366394018545 pantothenate kinase; Provisional; Region: PRK05439 366394018546 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 366394018547 ATP-binding site [chemical binding]; other site 366394018548 CoA-binding site [chemical binding]; other site 366394018549 Mg2+-binding site [ion binding]; other site 366394018550 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 366394018551 metal binding site [ion binding]; metal-binding site 366394018552 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 366394018553 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 366394018554 substrate binding site [chemical binding]; other site 366394018555 glutamase interaction surface [polypeptide binding]; other site 366394018556 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 366394018557 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 366394018558 catalytic residues [active] 366394018559 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 366394018560 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 366394018561 putative active site [active] 366394018562 oxyanion strand; other site 366394018563 catalytic triad [active] 366394018564 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 366394018565 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 366394018566 putative active site pocket [active] 366394018567 4-fold oligomerization interface [polypeptide binding]; other site 366394018568 metal binding residues [ion binding]; metal-binding site 366394018569 3-fold/trimer interface [polypeptide binding]; other site 366394018570 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 366394018571 active site 366394018572 HslU subunit interaction site [polypeptide binding]; other site 366394018573 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 366394018574 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 366394018575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 366394018576 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 366394018577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394018578 Walker A motif; other site 366394018579 ATP binding site [chemical binding]; other site 366394018580 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 366394018581 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 366394018582 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 366394018583 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 366394018584 Cytochrome P450; Region: p450; cl12078 366394018585 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 366394018586 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 366394018587 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 366394018588 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 366394018589 active site 366394018590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 366394018591 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 366394018592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5321 366394018593 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 366394018594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394018595 active site 366394018596 phosphorylation site [posttranslational modification] 366394018597 intermolecular recognition site; other site 366394018598 dimerization interface [polypeptide binding]; other site 366394018599 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 366394018600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 366394018601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 366394018602 dimer interface [polypeptide binding]; other site 366394018603 phosphorylation site [posttranslational modification] 366394018604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394018605 ATP binding site [chemical binding]; other site 366394018606 Mg2+ binding site [ion binding]; other site 366394018607 G-X-G motif; other site 366394018608 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 366394018609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 366394018610 ATP binding site [chemical binding]; other site 366394018611 putative Mg++ binding site [ion binding]; other site 366394018612 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 366394018613 nucleotide binding region [chemical binding]; other site 366394018614 ATP-binding site [chemical binding]; other site 366394018615 Helicase associated domain (HA2); Region: HA2; pfam04408 366394018616 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 366394018617 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 366394018618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394018619 Walker A/P-loop; other site 366394018620 ATP binding site [chemical binding]; other site 366394018621 Q-loop/lid; other site 366394018622 ABC transporter signature motif; other site 366394018623 Walker B; other site 366394018624 D-loop; other site 366394018625 H-loop/switch region; other site 366394018626 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 366394018627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 366394018628 hypothetical protein; Provisional; Region: PRK11622 366394018629 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 366394018630 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 366394018631 HAMP domain; Region: HAMP; pfam00672 366394018632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 366394018633 ATP binding site [chemical binding]; other site 366394018634 Mg2+ binding site [ion binding]; other site 366394018635 G-X-G motif; other site 366394018636 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 366394018637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394018638 active site 366394018639 phosphorylation site [posttranslational modification] 366394018640 intermolecular recognition site; other site 366394018641 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 366394018642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 366394018643 active site 366394018644 phosphorylation site [posttranslational modification] 366394018645 intermolecular recognition site; other site 366394018646 dimerization interface [polypeptide binding]; other site 366394018647 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 366394018648 DNA binding site [nucleotide binding] 366394018649 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 366394018650 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 366394018651 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 366394018652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394018653 Walker A/P-loop; other site 366394018654 ATP binding site [chemical binding]; other site 366394018655 Q-loop/lid; other site 366394018656 ABC transporter signature motif; other site 366394018657 Walker B; other site 366394018658 D-loop; other site 366394018659 H-loop/switch region; other site 366394018660 TOBE domain; Region: TOBE_2; pfam08402 366394018661 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 366394018662 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 366394018663 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 366394018664 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 366394018665 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 366394018666 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 366394018667 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 366394018668 hydroxyglutarate oxidase; Provisional; Region: PRK11728 366394018669 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 366394018670 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 366394018671 conserved cys residue [active] 366394018672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394018673 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 366394018674 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 366394018675 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 366394018676 putative active site [active] 366394018677 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 366394018678 domain_subunit interface; other site 366394018679 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 366394018680 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 366394018681 active site 366394018682 FMN binding site [chemical binding]; other site 366394018683 substrate binding site [chemical binding]; other site 366394018684 3Fe-4S cluster binding site [ion binding]; other site 366394018685 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 366394018686 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 366394018687 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 366394018688 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 366394018689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394018690 non-specific DNA binding site [nucleotide binding]; other site 366394018691 salt bridge; other site 366394018692 sequence-specific DNA binding site [nucleotide binding]; other site 366394018693 Cupin domain; Region: Cupin_2; pfam07883 366394018694 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 366394018695 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394018696 Walker A/P-loop; other site 366394018697 ATP binding site [chemical binding]; other site 366394018698 Q-loop/lid; other site 366394018699 ABC transporter signature motif; other site 366394018700 Walker B; other site 366394018701 D-loop; other site 366394018702 H-loop/switch region; other site 366394018703 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 366394018704 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 366394018705 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394018706 Walker A/P-loop; other site 366394018707 ATP binding site [chemical binding]; other site 366394018708 Q-loop/lid; other site 366394018709 ABC transporter signature motif; other site 366394018710 Walker B; other site 366394018711 D-loop; other site 366394018712 H-loop/switch region; other site 366394018713 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 366394018714 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 366394018715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394018716 dimer interface [polypeptide binding]; other site 366394018717 conserved gate region; other site 366394018718 putative PBP binding loops; other site 366394018719 ABC-ATPase subunit interface; other site 366394018720 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 366394018721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394018722 dimer interface [polypeptide binding]; other site 366394018723 conserved gate region; other site 366394018724 putative PBP binding loops; other site 366394018725 ABC-ATPase subunit interface; other site 366394018726 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 366394018727 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 366394018728 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 366394018729 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 366394018730 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 366394018731 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 366394018732 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 366394018733 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394018734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394018735 non-specific DNA binding site [nucleotide binding]; other site 366394018736 salt bridge; other site 366394018737 sequence-specific DNA binding site [nucleotide binding]; other site 366394018738 Cupin domain; Region: Cupin_2; pfam07883 366394018739 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 366394018740 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 366394018741 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 366394018742 putative active site [active] 366394018743 putative substrate binding site [chemical binding]; other site 366394018744 putative cosubstrate binding site; other site 366394018745 catalytic site [active] 366394018746 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 366394018747 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 366394018748 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 366394018749 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 366394018750 FMN-binding pocket [chemical binding]; other site 366394018751 flavin binding motif; other site 366394018752 phosphate binding motif [ion binding]; other site 366394018753 beta-alpha-beta structure motif; other site 366394018754 NAD binding pocket [chemical binding]; other site 366394018755 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 366394018756 catalytic loop [active] 366394018757 iron binding site [ion binding]; other site 366394018758 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 366394018759 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 366394018760 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 366394018761 Uncharacterized conserved protein [Function unknown]; Region: COG3665 366394018762 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 366394018763 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 366394018764 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 366394018765 Amino acid permease; Region: AA_permease_2; pfam13520 366394018766 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 366394018767 extended (e) SDRs; Region: SDR_e; cd08946 366394018768 NAD(P) binding site [chemical binding]; other site 366394018769 active site 366394018770 substrate binding site [chemical binding]; other site 366394018771 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 366394018772 Transcriptional regulators [Transcription]; Region: FadR; COG2186 366394018773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394018774 DNA-binding site [nucleotide binding]; DNA binding site 366394018775 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 366394018776 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 366394018777 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394018778 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 366394018779 C-terminal domain interface [polypeptide binding]; other site 366394018780 GSH binding site (G-site) [chemical binding]; other site 366394018781 dimer interface [polypeptide binding]; other site 366394018782 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 366394018783 N-terminal domain interface [polypeptide binding]; other site 366394018784 dimer interface [polypeptide binding]; other site 366394018785 substrate binding pocket (H-site) [chemical binding]; other site 366394018786 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394018787 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394018788 Walker A/P-loop; other site 366394018789 ATP binding site [chemical binding]; other site 366394018790 Q-loop/lid; other site 366394018791 ABC transporter signature motif; other site 366394018792 Walker B; other site 366394018793 D-loop; other site 366394018794 H-loop/switch region; other site 366394018795 TOBE domain; Region: TOBE; cl01440 366394018796 TOBE domain; Region: TOBE_2; pfam08402 366394018797 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394018798 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394018799 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394018800 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394018801 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394018802 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394018803 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394018804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394018805 dimer interface [polypeptide binding]; other site 366394018806 conserved gate region; other site 366394018807 putative PBP binding loops; other site 366394018808 ABC-ATPase subunit interface; other site 366394018809 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394018810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394018811 dimer interface [polypeptide binding]; other site 366394018812 conserved gate region; other site 366394018813 putative PBP binding loops; other site 366394018814 ABC-ATPase subunit interface; other site 366394018815 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394018816 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394018817 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 366394018818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394018819 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394018820 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394018821 Protein of unknown function (DUF993); Region: DUF993; pfam06187 366394018822 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 366394018823 metal binding site [ion binding]; metal-binding site 366394018824 substrate binding pocket [chemical binding]; other site 366394018825 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 366394018826 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 366394018827 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394018828 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394018829 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394018830 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 366394018831 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 366394018832 metal-binding site [ion binding] 366394018833 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 366394018834 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 366394018835 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 366394018836 Walker A/P-loop; other site 366394018837 ATP binding site [chemical binding]; other site 366394018838 Q-loop/lid; other site 366394018839 ABC transporter signature motif; other site 366394018840 Walker B; other site 366394018841 D-loop; other site 366394018842 H-loop/switch region; other site 366394018843 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 366394018844 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394018845 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 366394018846 TM-ABC transporter signature motif; other site 366394018847 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 366394018848 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 366394018849 TM-ABC transporter signature motif; other site 366394018850 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 366394018851 active site 366394018852 catalytic motif [active] 366394018853 Zn binding site [ion binding]; other site 366394018854 purine nucleoside phosphorylase; Provisional; Region: PRK08202 366394018855 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 366394018856 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 366394018857 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 366394018858 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 366394018859 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 366394018860 active site 366394018861 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 366394018862 adenosine deaminase; Provisional; Region: PRK09358 366394018863 active site 366394018864 phosphopentomutase; Provisional; Region: PRK05362 366394018865 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 366394018866 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 366394018867 TadE-like protein; Region: TadE; pfam07811 366394018868 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 366394018869 TadE-like protein; Region: TadE; pfam07811 366394018870 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 366394018871 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 366394018872 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 366394018873 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 366394018874 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 366394018875 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 366394018876 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 366394018877 BON domain; Region: BON; pfam04972 366394018878 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 366394018879 Type IV pili component [Cell motility and secretion]; Region: COG5461 366394018880 pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522 366394018881 AAA domain; Region: AAA_31; pfam13614 366394018882 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 366394018883 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 366394018884 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 366394018885 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 366394018886 ATP binding site [chemical binding]; other site 366394018887 Walker A motif; other site 366394018888 hexamer interface [polypeptide binding]; other site 366394018889 Walker B motif; other site 366394018890 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 366394018891 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 366394018892 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 366394018893 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 366394018894 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 366394018895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 366394018896 TPR motif; other site 366394018897 binding surface 366394018898 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 366394018899 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 366394018900 interface (dimer of trimers) [polypeptide binding]; other site 366394018901 Substrate-binding/catalytic site; other site 366394018902 Zn-binding sites [ion binding]; other site 366394018903 Transcriptional regulators [Transcription]; Region: MarR; COG1846 366394018904 MarR family; Region: MarR; pfam01047 366394018905 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 366394018906 NlpC/P60 family; Region: NLPC_P60; cl17555 366394018907 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 366394018908 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 366394018909 putative ligand binding site [chemical binding]; other site 366394018910 NAD binding site [chemical binding]; other site 366394018911 dimerization interface [polypeptide binding]; other site 366394018912 catalytic site [active] 366394018913 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 366394018914 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394018915 Walker A/P-loop; other site 366394018916 ATP binding site [chemical binding]; other site 366394018917 Q-loop/lid; other site 366394018918 ABC transporter signature motif; other site 366394018919 Walker B; other site 366394018920 D-loop; other site 366394018921 H-loop/switch region; other site 366394018922 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 366394018923 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 366394018924 Walker A/P-loop; other site 366394018925 ATP binding site [chemical binding]; other site 366394018926 Q-loop/lid; other site 366394018927 ABC transporter signature motif; other site 366394018928 Walker B; other site 366394018929 D-loop; other site 366394018930 H-loop/switch region; other site 366394018931 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 366394018932 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 366394018933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394018934 dimer interface [polypeptide binding]; other site 366394018935 conserved gate region; other site 366394018936 putative PBP binding loops; other site 366394018937 ABC-ATPase subunit interface; other site 366394018938 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 366394018939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394018940 dimer interface [polypeptide binding]; other site 366394018941 conserved gate region; other site 366394018942 putative PBP binding loops; other site 366394018943 ABC-ATPase subunit interface; other site 366394018944 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 366394018945 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 366394018946 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 366394018947 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 366394018948 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 366394018949 active site 366394018950 dimer interfaces [polypeptide binding]; other site 366394018951 catalytic residues [active] 366394018952 glucokinase; Provisional; Region: glk; PRK00292 366394018953 glucokinase, proteobacterial type; Region: glk; TIGR00749 366394018954 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 366394018955 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 366394018956 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 366394018957 Walker A/P-loop; other site 366394018958 ATP binding site [chemical binding]; other site 366394018959 Q-loop/lid; other site 366394018960 ABC transporter signature motif; other site 366394018961 Walker B; other site 366394018962 D-loop; other site 366394018963 H-loop/switch region; other site 366394018964 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 366394018965 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 366394018966 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 366394018967 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 366394018968 catalytic core [active] 366394018969 Helix-turn-helix domain; Region: HTH_18; pfam12833 366394018970 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 366394018971 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 366394018972 DNA binding site [nucleotide binding] 366394018973 active site 366394018974 Integral membrane protein [Function unknown]; Region: COG5488 366394018975 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 366394018976 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 366394018977 minor groove reading motif; other site 366394018978 helix-hairpin-helix signature motif; other site 366394018979 substrate binding pocket [chemical binding]; other site 366394018980 active site 366394018981 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 366394018982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394018983 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 366394018984 putative dimer interface [polypeptide binding]; other site 366394018985 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394018986 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 366394018987 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 366394018988 substrate binding site [chemical binding]; other site 366394018989 ATP binding site [chemical binding]; other site 366394018990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 366394018991 Bacterial SH3 domain; Region: SH3_4; pfam06347 366394018992 Bacterial SH3 domain; Region: SH3_4; pfam06347 366394018993 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 366394018994 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 366394018995 dimerization interface [polypeptide binding]; other site 366394018996 ligand binding site [chemical binding]; other site 366394018997 NADP binding site [chemical binding]; other site 366394018998 catalytic site [active] 366394018999 5'-3' exonuclease; Region: 53EXOc; smart00475 366394019000 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 366394019001 active site 366394019002 metal binding site 1 [ion binding]; metal-binding site 366394019003 putative 5' ssDNA interaction site; other site 366394019004 metal binding site 3; metal-binding site 366394019005 metal binding site 2 [ion binding]; metal-binding site 366394019006 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 366394019007 putative DNA binding site [nucleotide binding]; other site 366394019008 putative metal binding site [ion binding]; other site 366394019009 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 366394019010 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 366394019011 active site 366394019012 catalytic site [active] 366394019013 substrate binding site [chemical binding]; other site 366394019014 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 366394019015 active site 366394019016 DNA binding site [nucleotide binding] 366394019017 catalytic site [active] 366394019018 MarR family; Region: MarR; pfam01047 366394019019 hypothetical protein; Validated; Region: PRK09104 366394019020 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 366394019021 metal binding site [ion binding]; metal-binding site 366394019022 putative dimer interface [polypeptide binding]; other site 366394019023 Predicted integral membrane protein [Function unknown]; Region: COG0392 366394019024 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 366394019025 EamA-like transporter family; Region: EamA; pfam00892 366394019026 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 366394019027 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 366394019028 Transglycosylase; Region: Transgly; pfam00912 366394019029 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 366394019030 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 366394019031 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 366394019032 nucleotide binding site [chemical binding]; other site 366394019033 NEF interaction site [polypeptide binding]; other site 366394019034 SBD interface [polypeptide binding]; other site 366394019035 chaperone protein DnaJ; Provisional; Region: PRK10767 366394019036 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 366394019037 HSP70 interaction site [polypeptide binding]; other site 366394019038 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 366394019039 substrate binding site [polypeptide binding]; other site 366394019040 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 366394019041 Zn binding sites [ion binding]; other site 366394019042 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 366394019043 dimer interface [polypeptide binding]; other site 366394019044 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 366394019045 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 366394019046 Uncharacterized conserved protein [Function unknown]; Region: COG5588 366394019047 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 366394019048 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 366394019049 recombination protein F; Reviewed; Region: recF; PRK00064 366394019050 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 366394019051 Walker A/P-loop; other site 366394019052 ATP binding site [chemical binding]; other site 366394019053 Q-loop/lid; other site 366394019054 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 366394019055 ABC transporter signature motif; other site 366394019056 Walker B; other site 366394019057 D-loop; other site 366394019058 H-loop/switch region; other site 366394019059 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 366394019060 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 366394019061 ATP binding site [chemical binding]; other site 366394019062 substrate interface [chemical binding]; other site 366394019063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 366394019064 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 366394019065 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 366394019066 Protein export membrane protein; Region: SecD_SecF; cl14618 366394019067 Protein export membrane protein; Region: SecD_SecF; cl14618 366394019068 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 366394019069 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 366394019070 HlyD family secretion protein; Region: HlyD_3; pfam13437 366394019071 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 366394019072 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 366394019073 Walker A/P-loop; other site 366394019074 ATP binding site [chemical binding]; other site 366394019075 Q-loop/lid; other site 366394019076 ABC transporter signature motif; other site 366394019077 Walker B; other site 366394019078 D-loop; other site 366394019079 H-loop/switch region; other site 366394019080 TOBE domain; Region: TOBE_2; pfam08402 366394019081 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394019082 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394019083 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 366394019084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394019085 dimer interface [polypeptide binding]; other site 366394019086 conserved gate region; other site 366394019087 putative PBP binding loops; other site 366394019088 ABC-ATPase subunit interface; other site 366394019089 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 366394019090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 366394019091 dimer interface [polypeptide binding]; other site 366394019092 conserved gate region; other site 366394019093 putative PBP binding loops; other site 366394019094 ABC-ATPase subunit interface; other site 366394019095 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 366394019096 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 366394019097 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 366394019098 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 366394019099 putative active site [active] 366394019100 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 366394019101 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 366394019102 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 366394019103 DNA-binding site [nucleotide binding]; DNA binding site 366394019104 UTRA domain; Region: UTRA; pfam07702 366394019105 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 366394019106 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 366394019107 dimer interface [polypeptide binding]; other site 366394019108 active site 366394019109 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 366394019110 dimer interface [polypeptide binding]; other site 366394019111 active site 366394019112 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 366394019113 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 366394019114 active site 366394019115 dimer interface [polypeptide binding]; other site 366394019116 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 366394019117 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 366394019118 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 366394019119 nucleotide binding site [chemical binding]; other site 366394019120 hypothetical protein; Provisional; Region: PRK06102 366394019121 Amidase; Region: Amidase; cl11426 366394019122 CysZ-like protein; Reviewed; Region: PRK12768 366394019123 hypothetical protein; Provisional; Region: PRK00736 366394019124 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 366394019125 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 366394019126 ligand binding site [chemical binding]; other site 366394019127 methionine sulfoxide reductase A; Provisional; Region: PRK00058 366394019128 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394019129 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394019130 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 366394019131 putative substrate binding pocket [chemical binding]; other site 366394019132 putative dimerization interface [polypeptide binding]; other site 366394019133 BON domain; Region: BON; pfam04972 366394019134 Predicted permeases [General function prediction only]; Region: COG0679 366394019135 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 366394019136 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 366394019137 homodimer interface [polypeptide binding]; other site 366394019138 substrate-cofactor binding pocket; other site 366394019139 catalytic residue [active] 366394019140 Cytochrome c2 [Energy production and conversion]; Region: COG3474 366394019141 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 366394019142 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 366394019143 Ligand binding site; other site 366394019144 oligomer interface; other site 366394019145 prephenate dehydratase; Provisional; Region: PRK11899 366394019146 Prephenate dehydratase; Region: PDT; pfam00800 366394019147 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 366394019148 putative L-Phe binding site [chemical binding]; other site 366394019149 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 366394019150 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 366394019151 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 366394019152 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 366394019153 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 366394019154 putative NADH binding site [chemical binding]; other site 366394019155 putative active site [active] 366394019156 nudix motif; other site 366394019157 putative metal binding site [ion binding]; other site 366394019158 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 366394019159 nucleotide binding site/active site [active] 366394019160 HIT family signature motif; other site 366394019161 catalytic residue [active] 366394019162 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 366394019163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394019164 Walker A motif; other site 366394019165 ATP binding site [chemical binding]; other site 366394019166 Walker B motif; other site 366394019167 arginine finger; other site 366394019168 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 366394019169 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 366394019170 hypothetical protein; Validated; Region: PRK00153 366394019171 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 366394019172 recombination protein RecR; Reviewed; Region: recR; PRK00076 366394019173 RecR protein; Region: RecR; pfam02132 366394019174 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 366394019175 putative active site [active] 366394019176 putative metal-binding site [ion binding]; other site 366394019177 tetramer interface [polypeptide binding]; other site 366394019178 Transglycosylase SLT domain; Region: SLT_2; pfam13406 366394019179 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 366394019180 N-acetyl-D-glucosamine binding site [chemical binding]; other site 366394019181 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 366394019182 Transmembrane secretion effector; Region: MFS_3; pfam05977 366394019183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394019184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394019185 ribosome maturation protein RimP; Reviewed; Region: PRK00092 366394019186 Sm and related proteins; Region: Sm_like; cl00259 366394019187 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 366394019188 putative oligomer interface [polypeptide binding]; other site 366394019189 putative RNA binding site [nucleotide binding]; other site 366394019190 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 366394019191 NusA N-terminal domain; Region: NusA_N; pfam08529 366394019192 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 366394019193 RNA binding site [nucleotide binding]; other site 366394019194 homodimer interface [polypeptide binding]; other site 366394019195 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 366394019196 G-X-X-G motif; other site 366394019197 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 366394019198 G-X-X-G motif; other site 366394019199 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 366394019200 hypothetical protein; Provisional; Region: PRK09190 366394019201 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 366394019202 putative RNA binding cleft [nucleotide binding]; other site 366394019203 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 366394019204 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 366394019205 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 366394019206 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 366394019207 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 366394019208 G1 box; other site 366394019209 putative GEF interaction site [polypeptide binding]; other site 366394019210 GTP/Mg2+ binding site [chemical binding]; other site 366394019211 Switch I region; other site 366394019212 G2 box; other site 366394019213 G3 box; other site 366394019214 Switch II region; other site 366394019215 G4 box; other site 366394019216 G5 box; other site 366394019217 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 366394019218 Translation-initiation factor 2; Region: IF-2; pfam11987 366394019219 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 366394019220 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 366394019221 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 366394019222 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 366394019223 RNA binding site [nucleotide binding]; other site 366394019224 active site 366394019225 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 366394019226 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 366394019227 HWE histidine kinase; Region: HWE_HK; pfam07536 366394019228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 366394019229 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 366394019230 16S/18S rRNA binding site [nucleotide binding]; other site 366394019231 S13e-L30e interaction site [polypeptide binding]; other site 366394019232 25S rRNA binding site [nucleotide binding]; other site 366394019233 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 366394019234 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 366394019235 RNase E interface [polypeptide binding]; other site 366394019236 trimer interface [polypeptide binding]; other site 366394019237 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 366394019238 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 366394019239 RNase E interface [polypeptide binding]; other site 366394019240 trimer interface [polypeptide binding]; other site 366394019241 active site 366394019242 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 366394019243 putative nucleic acid binding region [nucleotide binding]; other site 366394019244 G-X-X-G motif; other site 366394019245 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 366394019246 RNA binding site [nucleotide binding]; other site 366394019247 domain interface; other site 366394019248 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 366394019249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 366394019250 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 366394019251 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 366394019252 NAD binding site [chemical binding]; other site 366394019253 homotetramer interface [polypeptide binding]; other site 366394019254 homodimer interface [polypeptide binding]; other site 366394019255 substrate binding site [chemical binding]; other site 366394019256 active site 366394019257 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 366394019258 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 366394019259 dimer interface [polypeptide binding]; other site 366394019260 active site 366394019261 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 366394019262 active site 1 [active] 366394019263 dimer interface [polypeptide binding]; other site 366394019264 active site 2 [active] 366394019265 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 366394019266 metal binding site 2 [ion binding]; metal-binding site 366394019267 putative DNA binding helix; other site 366394019268 metal binding site 1 [ion binding]; metal-binding site 366394019269 dimer interface [polypeptide binding]; other site 366394019270 Predicted membrane protein [Function unknown]; Region: COG2860 366394019271 UPF0126 domain; Region: UPF0126; pfam03458 366394019272 UPF0126 domain; Region: UPF0126; pfam03458 366394019273 Uncharacterized conserved protein [Function unknown]; Region: COG1434 366394019274 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 366394019275 putative active site [active] 366394019276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 366394019277 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 366394019278 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 366394019279 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 366394019280 hinge; other site 366394019281 active site 366394019282 cytidylate kinase; Provisional; Region: cmk; PRK00023 366394019283 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 366394019284 CMP-binding site; other site 366394019285 The sites determining sugar specificity; other site 366394019286 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 366394019287 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 366394019288 RNA binding site [nucleotide binding]; other site 366394019289 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 366394019290 RNA binding site [nucleotide binding]; other site 366394019291 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 366394019292 RNA binding site [nucleotide binding]; other site 366394019293 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 366394019294 RNA binding site [nucleotide binding]; other site 366394019295 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 366394019296 RNA binding site [nucleotide binding]; other site 366394019297 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 366394019298 RNA binding site [nucleotide binding]; other site 366394019299 BA14K-like protein; Region: BA14K; pfam07886 366394019300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 366394019301 dimerization interface [polypeptide binding]; other site 366394019302 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 366394019303 cyclase homology domain; Region: CHD; cd07302 366394019304 nucleotidyl binding site; other site 366394019305 metal binding site [ion binding]; metal-binding site 366394019306 dimer interface [polypeptide binding]; other site 366394019307 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 366394019308 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 366394019309 catalytic site [active] 366394019310 putative active site [active] 366394019311 putative substrate binding site [chemical binding]; other site 366394019312 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 366394019313 Predicted membrane protein [Function unknown]; Region: COG2259 366394019314 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 366394019315 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 366394019316 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394019317 GTP-binding protein LepA; Provisional; Region: PRK05433 366394019318 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 366394019319 G1 box; other site 366394019320 putative GEF interaction site [polypeptide binding]; other site 366394019321 GTP/Mg2+ binding site [chemical binding]; other site 366394019322 Switch I region; other site 366394019323 G2 box; other site 366394019324 G3 box; other site 366394019325 Switch II region; other site 366394019326 G4 box; other site 366394019327 G5 box; other site 366394019328 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 366394019329 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 366394019330 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 366394019331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 366394019332 putative substrate translocation pore; other site 366394019333 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394019334 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394019335 non-specific DNA binding site [nucleotide binding]; other site 366394019336 salt bridge; other site 366394019337 sequence-specific DNA binding site [nucleotide binding]; other site 366394019338 Cupin domain; Region: Cupin_2; cl17218 366394019339 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 366394019340 Coenzyme A binding pocket [chemical binding]; other site 366394019341 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 366394019342 putative outer membrane lipoprotein; Provisional; Region: PRK10510 366394019343 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 366394019344 ligand binding site [chemical binding]; other site 366394019345 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 366394019346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 366394019347 FeS/SAM binding site; other site 366394019348 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 366394019349 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 366394019350 motif 1; other site 366394019351 dimer interface [polypeptide binding]; other site 366394019352 active site 366394019353 motif 2; other site 366394019354 motif 3; other site 366394019355 elongation factor P; Validated; Region: PRK00529 366394019356 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 366394019357 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 366394019358 RNA binding site [nucleotide binding]; other site 366394019359 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 366394019360 RNA binding site [nucleotide binding]; other site 366394019361 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 366394019362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 366394019363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394019364 S-adenosylmethionine binding site [chemical binding]; other site 366394019365 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 366394019366 diiron binding motif [ion binding]; other site 366394019367 Uncharacterized conserved protein [Function unknown]; Region: COG1633 366394019368 CCC1-related protein family; Region: CCC1_like_1; cd02437 366394019369 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 366394019370 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 366394019371 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 366394019372 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 366394019373 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 366394019374 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 366394019375 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 366394019376 23S rRNA binding site [nucleotide binding]; other site 366394019377 L21 binding site [polypeptide binding]; other site 366394019378 L13 binding site [polypeptide binding]; other site 366394019379 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 366394019380 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 366394019381 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 366394019382 dimer interface [polypeptide binding]; other site 366394019383 motif 1; other site 366394019384 active site 366394019385 motif 2; other site 366394019386 motif 3; other site 366394019387 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 366394019388 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 366394019389 putative tRNA-binding site [nucleotide binding]; other site 366394019390 B3/4 domain; Region: B3_4; pfam03483 366394019391 tRNA synthetase B5 domain; Region: B5; smart00874 366394019392 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 366394019393 dimer interface [polypeptide binding]; other site 366394019394 motif 1; other site 366394019395 motif 3; other site 366394019396 motif 2; other site 366394019397 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 366394019398 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 366394019399 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394019400 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394019401 active site 366394019402 catalytic tetrad [active] 366394019403 Transcriptional regulator [Transcription]; Region: LysR; COG0583 366394019404 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 366394019405 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 366394019406 putative effector binding pocket; other site 366394019407 putative dimerization interface [polypeptide binding]; other site 366394019408 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 366394019409 dimerization interface [polypeptide binding]; other site 366394019410 metal binding site [ion binding]; metal-binding site 366394019411 short chain dehydrogenase; Provisional; Region: PRK07478 366394019412 classical (c) SDRs; Region: SDR_c; cd05233 366394019413 NAD(P) binding site [chemical binding]; other site 366394019414 active site 366394019415 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 366394019416 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 366394019417 active site 366394019418 catalytic tetrad [active] 366394019419 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394019420 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394019421 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394019422 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 366394019423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 366394019424 non-specific DNA binding site [nucleotide binding]; other site 366394019425 salt bridge; other site 366394019426 sequence-specific DNA binding site [nucleotide binding]; other site 366394019427 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 366394019428 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 366394019429 generic binding surface II; other site 366394019430 generic binding surface I; other site 366394019431 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 366394019432 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 366394019433 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 366394019434 MarR family; Region: MarR; pfam01047 366394019435 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 366394019436 EamA-like transporter family; Region: EamA; pfam00892 366394019437 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 366394019438 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 366394019439 active site 366394019440 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 366394019441 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 366394019442 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 366394019443 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394019444 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 366394019445 C-terminal domain interface [polypeptide binding]; other site 366394019446 GSH binding site (G-site) [chemical binding]; other site 366394019447 dimer interface [polypeptide binding]; other site 366394019448 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 366394019449 N-terminal domain interface [polypeptide binding]; other site 366394019450 dimer interface [polypeptide binding]; other site 366394019451 substrate binding pocket (H-site) [chemical binding]; other site 366394019452 MarR family; Region: MarR_2; pfam12802 366394019453 Transcriptional regulators [Transcription]; Region: MarR; COG1846 366394019454 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 366394019455 putative deacylase active site [active] 366394019456 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 366394019457 ArsC family; Region: ArsC; pfam03960 366394019458 putative catalytic residues [active] 366394019459 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 366394019460 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 366394019461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394019462 homodimer interface [polypeptide binding]; other site 366394019463 catalytic residue [active] 366394019464 Predicted deacylase [General function prediction only]; Region: COG3608 366394019465 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 366394019466 active site 366394019467 Zn binding site [ion binding]; other site 366394019468 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394019469 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 366394019470 putative hydrophobic ligand binding site [chemical binding]; other site 366394019471 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394019472 putative DNA binding site [nucleotide binding]; other site 366394019473 dimerization interface [polypeptide binding]; other site 366394019474 putative Zn2+ binding site [ion binding]; other site 366394019475 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 366394019476 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 366394019477 phosphate binding site [ion binding]; other site 366394019478 GMP synthase; Reviewed; Region: guaA; PRK00074 366394019479 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 366394019480 AMP/PPi binding site [chemical binding]; other site 366394019481 candidate oxyanion hole; other site 366394019482 catalytic triad [active] 366394019483 potential glutamine specificity residues [chemical binding]; other site 366394019484 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 366394019485 ATP Binding subdomain [chemical binding]; other site 366394019486 Ligand Binding sites [chemical binding]; other site 366394019487 Dimerization subdomain; other site 366394019488 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 366394019489 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 366394019490 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 366394019491 CoenzymeA binding site [chemical binding]; other site 366394019492 subunit interaction site [polypeptide binding]; other site 366394019493 PHB binding site; other site 366394019494 TspO/MBR family; Region: TspO_MBR; pfam03073 366394019495 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 366394019496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 366394019497 Coenzyme A binding pocket [chemical binding]; other site 366394019498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 366394019499 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 366394019500 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 366394019501 haemagglutination activity domain; Region: Haemagg_act; smart00912 366394019502 FG-GAP repeat; Region: FG-GAP_2; pfam14312 366394019503 FG-GAP repeat; Region: FG-GAP_2; pfam14312 366394019504 FG-GAP repeat; Region: FG-GAP_2; pfam14312 366394019505 FG-GAP repeat; Region: FG-GAP_2; pfam14312 366394019506 FG-GAP repeat; Region: FG-GAP_2; pfam14312 366394019507 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 366394019508 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG3489 366394019509 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 366394019510 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 366394019511 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 366394019512 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 366394019513 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 366394019514 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 366394019515 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 366394019516 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 366394019517 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 366394019518 putative NAD(P) binding site [chemical binding]; other site 366394019519 epoxyqueuosine reductase; Region: TIGR00276 366394019520 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 366394019521 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 366394019522 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 366394019523 C-terminal domain interface [polypeptide binding]; other site 366394019524 GSH binding site (G-site) [chemical binding]; other site 366394019525 dimer interface [polypeptide binding]; other site 366394019526 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 366394019527 N-terminal domain interface [polypeptide binding]; other site 366394019528 dimer interface [polypeptide binding]; other site 366394019529 substrate binding pocket (H-site) [chemical binding]; other site 366394019530 Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968 366394019531 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 366394019532 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 366394019533 putative NAD(P) binding site [chemical binding]; other site 366394019534 active site 366394019535 Uncharacterized conserved protein [Function unknown]; Region: COG5470 366394019536 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 366394019537 active site 366394019538 dimer interface [polypeptide binding]; other site 366394019539 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 366394019540 catalytic core [active] 366394019541 Methyltransferase domain; Region: Methyltransf_31; pfam13847 366394019542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394019543 S-adenosylmethionine binding site [chemical binding]; other site 366394019544 DNA polymerase III subunit beta; Validated; Region: PRK05643 366394019545 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 366394019546 putative DNA binding surface [nucleotide binding]; other site 366394019547 dimer interface [polypeptide binding]; other site 366394019548 beta-clamp/clamp loader binding surface; other site 366394019549 beta-clamp/translesion DNA polymerase binding surface; other site 366394019550 Predicted methyltransferases [General function prediction only]; Region: COG0313 366394019551 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 366394019552 putative SAM binding site [chemical binding]; other site 366394019553 putative homodimer interface [polypeptide binding]; other site 366394019554 hypothetical protein; Reviewed; Region: PRK12497 366394019555 glutathione synthetase; Provisional; Region: PRK05246 366394019556 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 366394019557 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 366394019558 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 366394019559 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 366394019560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 366394019561 Walker A motif; other site 366394019562 ATP binding site [chemical binding]; other site 366394019563 Walker B motif; other site 366394019564 arginine finger; other site 366394019565 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 366394019566 Src Homology 3 domain superfamily; Region: SH3; cl17036 366394019567 Src Homology 3 domain superfamily; Region: SH3; cd00174 366394019568 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 366394019569 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 366394019570 dimer interface [polypeptide binding]; other site 366394019571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 366394019572 catalytic residue [active] 366394019573 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 366394019574 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 366394019575 EamA-like transporter family; Region: EamA; pfam00892 366394019576 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 366394019577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 366394019578 putative DNA binding site [nucleotide binding]; other site 366394019579 putative Zn2+ binding site [ion binding]; other site 366394019580 AsnC family; Region: AsnC_trans_reg; pfam01037 366394019581 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 366394019582 trimer interface [polypeptide binding]; other site 366394019583 active site 366394019584 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 366394019585 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 366394019586 G1 box; other site 366394019587 putative GEF interaction site [polypeptide binding]; other site 366394019588 GTP/Mg2+ binding site [chemical binding]; other site 366394019589 Switch I region; other site 366394019590 G2 box; other site 366394019591 G3 box; other site 366394019592 Switch II region; other site 366394019593 G4 box; other site 366394019594 G5 box; other site 366394019595 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 366394019596 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 366394019597 EamA-like transporter family; Region: EamA; pfam00892 366394019598 EamA-like transporter family; Region: EamA; pfam00892 366394019599 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 366394019600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 366394019601 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 366394019602 Uncharacterized conserved protein [Function unknown]; Region: COG3791 366394019603 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 366394019604 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 366394019605 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 366394019606 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 366394019607 dimer interface [polypeptide binding]; other site 366394019608 PYR/PP interface [polypeptide binding]; other site 366394019609 TPP binding site [chemical binding]; other site 366394019610 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 366394019611 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 366394019612 TPP-binding site [chemical binding]; other site 366394019613 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 366394019614 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 366394019615 substrate binding site [chemical binding]; other site 366394019616 ATP binding site [chemical binding]; other site 366394019617 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 366394019618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 366394019619 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 366394019620 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 366394019621 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 366394019622 putative active site [active] 366394019623 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 366394019624 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 366394019625 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 366394019626 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 366394019627 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 366394019628 putative active site [active] 366394019629 putative dimer interface [polypeptide binding]; other site 366394019630 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 366394019631 Flavoprotein; Region: Flavoprotein; pfam02441 366394019632 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 366394019633 Predicted transcriptional regulator [Transcription]; Region: COG1959 366394019634 Transcriptional regulator; Region: Rrf2; pfam02082 366394019635 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 366394019636 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 366394019637 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 366394019638 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 366394019639 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 366394019640 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 366394019641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 366394019642 NAD(P) binding site [chemical binding]; other site 366394019643 active site 366394019644 ABC1 family; Region: ABC1; cl17513 366394019645 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 366394019646 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 366394019647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 366394019648 S-adenosylmethionine binding site [chemical binding]; other site 366394019649 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 366394019650 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 366394019651 DNA binding site [nucleotide binding] 366394019652 catalytic residue [active] 366394019653 H2TH interface [polypeptide binding]; other site 366394019654 putative catalytic residues [active] 366394019655 turnover-facilitating residue; other site 366394019656 intercalation triad [nucleotide binding]; other site 366394019657 8OG recognition residue [nucleotide binding]; other site 366394019658 putative reading head residues; other site 366394019659 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 366394019660 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 366394019661 enoyl-CoA hydratase; Provisional; Region: PRK05862 366394019662 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 366394019663 substrate binding site [chemical binding]; other site 366394019664 oxyanion hole (OAH) forming residues; other site 366394019665 trimer interface [polypeptide binding]; other site