-- dump date   	20140620_070249
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
266834000001	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
266834000002	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
266834000003	[4Fe-4S] binding site [ion binding]; other site
266834000004	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
266834000005	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
266834000006	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
266834000007	molybdopterin cofactor binding site; other site
266834000008	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
266834000009	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
266834000010	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
266834000011	Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864
266834000012	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
266834000013	Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058
266834000014	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
266834000015	seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474
266834000016	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
266834000017	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
266834000018	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
266834000019	catalytic residue [active]
266834000020	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
266834000021	Sel1-like repeats; Region: SEL1; smart00671
266834000022	Sel1-like repeats; Region: SEL1; smart00671
266834000023	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
266834000024	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
266834000025	G1 box; other site
266834000026	putative GEF interaction site [polypeptide binding]; other site
266834000027	GTP/Mg2+ binding site [chemical binding]; other site
266834000028	Switch I region; other site
266834000029	G2 box; other site
266834000030	G3 box; other site
266834000031	Switch II region; other site
266834000032	G4 box; other site
266834000033	G5 box; other site
266834000034	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
266834000035	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
266834000036	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
266834000037	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
266834000038	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
266834000039	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834000040	Homeodomain-like domain; Region: HTH_32; pfam13565
266834000041	DDE superfamily endonuclease; Region: DDE_3; pfam13358
266834000042	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
266834000043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834000044	active site
266834000045	phosphorylation site [posttranslational modification]
266834000046	intermolecular recognition site; other site
266834000047	dimerization interface [polypeptide binding]; other site
266834000048	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
266834000049	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
266834000050	selenophosphate synthetase; Provisional; Region: PRK00943
266834000051	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
266834000052	dimerization interface [polypeptide binding]; other site
266834000053	putative ATP binding site [chemical binding]; other site
266834000054	NADH dehydrogenase subunit C; Validated; Region: PRK07735
266834000055	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
266834000056	active site
266834000057	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
266834000058	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
266834000059	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
266834000060	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834000061	Walker A/P-loop; other site
266834000062	ATP binding site [chemical binding]; other site
266834000063	Q-loop/lid; other site
266834000064	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
266834000065	ABC transporter signature motif; other site
266834000066	Walker B; other site
266834000067	D-loop; other site
266834000068	ABC transporter; Region: ABC_tran_2; pfam12848
266834000069	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
266834000070	transcriptional regulator; Provisional; Region: PRK10632
266834000071	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834000072	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
266834000073	putative effector binding pocket; other site
266834000074	putative dimerization interface [polypeptide binding]; other site
266834000075	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
266834000076	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
266834000077	putative NAD(P) binding site [chemical binding]; other site
266834000078	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
266834000079	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
266834000080	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
266834000081	active site
266834000082	zinc binding site [ion binding]; other site
266834000083	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834000084	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
266834000085	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
266834000086	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
266834000087	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
266834000088	metal binding site [ion binding]; metal-binding site
266834000089	substrate binding pocket [chemical binding]; other site
266834000090	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
266834000091	dimerization interface [polypeptide binding]; other site
266834000092	putative active cleft [active]
266834000093	aldose dehydrogenase; Validated; Region: PRK06398
266834000094	classical (c) SDRs; Region: SDR_c; cd05233
266834000095	NAD(P) binding site [chemical binding]; other site
266834000096	active site
266834000097	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
266834000098	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834000099	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834000100	DNA-binding site [nucleotide binding]; DNA binding site
266834000101	FCD domain; Region: FCD; pfam07729
266834000102	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834000103	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834000104	DNA-binding site [nucleotide binding]; DNA binding site
266834000105	FCD domain; Region: FCD; pfam07729
266834000106	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
266834000107	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
266834000108	active site pocket [active]
266834000109	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834000110	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834000111	DNA-binding site [nucleotide binding]; DNA binding site
266834000112	FCD domain; Region: FCD; pfam07729
266834000113	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834000114	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
266834000115	putative ligand binding site [chemical binding]; other site
266834000116	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834000117	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834000118	TM-ABC transporter signature motif; other site
266834000119	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
266834000120	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834000121	Walker A/P-loop; other site
266834000122	ATP binding site [chemical binding]; other site
266834000123	Q-loop/lid; other site
266834000124	ABC transporter signature motif; other site
266834000125	Walker B; other site
266834000126	D-loop; other site
266834000127	H-loop/switch region; other site
266834000128	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
266834000129	classical (c) SDRs; Region: SDR_c; cd05233
266834000130	NAD(P) binding site [chemical binding]; other site
266834000131	active site
266834000132	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
266834000133	active site
266834000134	catalytic residues [active]
266834000135	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834000136	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834000137	DNA binding site [nucleotide binding]
266834000138	domain linker motif; other site
266834000139	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
266834000140	putative dimerization interface [polypeptide binding]; other site
266834000141	putative ligand binding site [chemical binding]; other site
266834000142	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834000143	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000144	dimer interface [polypeptide binding]; other site
266834000145	conserved gate region; other site
266834000146	putative PBP binding loops; other site
266834000147	ABC-ATPase subunit interface; other site
266834000148	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834000149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000150	dimer interface [polypeptide binding]; other site
266834000151	conserved gate region; other site
266834000152	putative PBP binding loops; other site
266834000153	ABC-ATPase subunit interface; other site
266834000154	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
266834000155	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834000156	substrate binding pocket [chemical binding]; other site
266834000157	membrane-bound complex binding site; other site
266834000158	hinge residues; other site
266834000159	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
266834000160	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
266834000161	Walker A/P-loop; other site
266834000162	ATP binding site [chemical binding]; other site
266834000163	Q-loop/lid; other site
266834000164	ABC transporter signature motif; other site
266834000165	Walker B; other site
266834000166	D-loop; other site
266834000167	H-loop/switch region; other site
266834000168	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
266834000169	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
266834000170	putative ligand binding site [chemical binding]; other site
266834000171	NAD binding site [chemical binding]; other site
266834000172	catalytic site [active]
266834000173	EthD domain; Region: EthD; cl17553
266834000174	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
266834000175	homotrimer interaction site [polypeptide binding]; other site
266834000176	putative active site [active]
266834000177	BA14K-like protein; Region: BA14K; pfam07886
266834000178	BA14K-like protein; Region: BA14K; pfam07886
266834000179	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
266834000180	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
266834000181	homodimer interface [polypeptide binding]; other site
266834000182	substrate-cofactor binding pocket; other site
266834000183	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834000184	catalytic residue [active]
266834000185	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
266834000186	homodimer interface [polypeptide binding]; other site
266834000187	homotetramer interface [polypeptide binding]; other site
266834000188	active site pocket [active]
266834000189	cleavage site
266834000190	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834000191	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834000192	LysR substrate binding domain; Region: LysR_substrate; pfam03466
266834000193	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
266834000194	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
266834000195	active site
266834000196	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
266834000197	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834000198	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834000199	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000200	dimer interface [polypeptide binding]; other site
266834000201	conserved gate region; other site
266834000202	putative PBP binding loops; other site
266834000203	ABC-ATPase subunit interface; other site
266834000204	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
266834000205	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000206	dimer interface [polypeptide binding]; other site
266834000207	conserved gate region; other site
266834000208	putative PBP binding loops; other site
266834000209	ABC-ATPase subunit interface; other site
266834000210	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
266834000211	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834000212	Walker A/P-loop; other site
266834000213	ATP binding site [chemical binding]; other site
266834000214	Q-loop/lid; other site
266834000215	ABC transporter signature motif; other site
266834000216	Walker B; other site
266834000217	D-loop; other site
266834000218	H-loop/switch region; other site
266834000219	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834000220	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
266834000221	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834000222	Walker A/P-loop; other site
266834000223	ATP binding site [chemical binding]; other site
266834000224	Q-loop/lid; other site
266834000225	ABC transporter signature motif; other site
266834000226	Walker B; other site
266834000227	D-loop; other site
266834000228	H-loop/switch region; other site
266834000229	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834000230	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
266834000231	Uncharacterized conserved protein [Function unknown]; Region: COG3791
266834000232	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834000233	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
266834000234	putative active site [active]
266834000235	heme pocket [chemical binding]; other site
266834000236	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834000237	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
266834000238	putative active site [active]
266834000239	heme pocket [chemical binding]; other site
266834000240	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834000241	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
266834000242	putative active site [active]
266834000243	heme pocket [chemical binding]; other site
266834000244	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834000245	putative active site [active]
266834000246	heme pocket [chemical binding]; other site
266834000247	PAS domain S-box; Region: sensory_box; TIGR00229
266834000248	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834000249	putative active site [active]
266834000250	heme pocket [chemical binding]; other site
266834000251	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
266834000252	HWE histidine kinase; Region: HWE_HK; pfam07536
266834000253	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834000254	active site
266834000255	phosphorylation site [posttranslational modification]
266834000256	intermolecular recognition site; other site
266834000257	dimerization interface [polypeptide binding]; other site
266834000258	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
266834000259	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
266834000260	HSP70 interaction site [polypeptide binding]; other site
266834000261	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
266834000262	substrate binding site [polypeptide binding]; other site
266834000263	dimer interface [polypeptide binding]; other site
266834000264	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
266834000265	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
266834000266	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
266834000267	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
266834000268	ring oligomerisation interface [polypeptide binding]; other site
266834000269	ATP/Mg binding site [chemical binding]; other site
266834000270	stacking interactions; other site
266834000271	hinge regions; other site
266834000272	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
266834000273	oligomerisation interface [polypeptide binding]; other site
266834000274	mobile loop; other site
266834000275	roof hairpin; other site
266834000276	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
266834000277	DNA-binding site [nucleotide binding]; DNA binding site
266834000278	RNA-binding motif; other site
266834000279	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
266834000280	Fatty acid desaturase; Region: FA_desaturase; pfam00487
266834000281	putative di-iron ligands [ion binding]; other site
266834000282	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
266834000283	Domain of unknown function DUF20; Region: UPF0118; pfam01594
266834000284	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322
266834000285	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
266834000286	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834000287	metal binding site [ion binding]; metal-binding site
266834000288	active site
266834000289	I-site; other site
266834000290	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834000291	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3865
266834000292	active site
266834000293	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
266834000294	active site
266834000295	catalytic triad [active]
266834000296	RNA polymerase sigma factor; Provisional; Region: PRK12547
266834000297	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
266834000298	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834000299	DNA binding residues [nucleotide binding]
266834000300	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
266834000301	transcription elongation factor regulatory protein; Validated; Region: PRK06342
266834000302	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
266834000303	malonyl-CoA synthase; Validated; Region: PRK07514
266834000304	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
266834000305	acyl-activating enzyme (AAE) consensus motif; other site
266834000306	active site
266834000307	AMP binding site [chemical binding]; other site
266834000308	CoA binding site [chemical binding]; other site
266834000309	DctM-like transporters; Region: DctM; pfam06808
266834000310	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
266834000311	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
266834000312	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
266834000313	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
266834000314	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
266834000315	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834000316	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834000317	DNA-binding site [nucleotide binding]; DNA binding site
266834000318	FCD domain; Region: FCD; pfam07729
266834000319	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
266834000320	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
266834000321	BON domain; Region: BON; pfam04972
266834000322	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
266834000323	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834000324	binding surface
266834000325	Tetratricopeptide repeat; Region: TPR_16; pfam13432
266834000326	TPR motif; other site
266834000327	hypothetical protein; Provisional; Region: PRK08317
266834000328	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834000329	S-adenosylmethionine binding site [chemical binding]; other site
266834000330	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834000331	S-adenosylmethionine binding site [chemical binding]; other site
266834000332	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
266834000333	Uncharacterized conserved protein [Function unknown]; Region: COG2326
266834000334	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
266834000335	Mechanosensitive ion channel; Region: MS_channel; pfam00924
266834000336	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
266834000337	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834000338	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
266834000339	dimerization interface [polypeptide binding]; other site
266834000340	substrate binding pocket [chemical binding]; other site
266834000341	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
266834000342	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
266834000343	DNA-binding site [nucleotide binding]; DNA binding site
266834000344	RNA-binding motif; other site
266834000345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834000346	putative substrate translocation pore; other site
266834000347	short chain dehydrogenase; Provisional; Region: PRK06701
266834000348	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834000349	NAD(P) binding site [chemical binding]; other site
266834000350	active site
266834000351	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834000352	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834000353	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
266834000354	putative hydrophobic ligand binding site [chemical binding]; other site
266834000355	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834000356	dimerization interface [polypeptide binding]; other site
266834000357	putative DNA binding site [nucleotide binding]; other site
266834000358	putative Zn2+ binding site [ion binding]; other site
266834000359	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
266834000360	Strictosidine synthase; Region: Str_synth; pfam03088
266834000361	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834000362	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834000363	TM-ABC transporter signature motif; other site
266834000364	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834000365	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834000366	TM-ABC transporter signature motif; other site
266834000367	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834000368	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834000369	Walker A/P-loop; other site
266834000370	ATP binding site [chemical binding]; other site
266834000371	Q-loop/lid; other site
266834000372	ABC transporter signature motif; other site
266834000373	Walker B; other site
266834000374	D-loop; other site
266834000375	H-loop/switch region; other site
266834000376	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834000377	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834000378	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
266834000379	putative ligand binding site [chemical binding]; other site
266834000380	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
266834000381	Histidine kinase; Region: HisKA_3; pfam07730
266834000382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834000383	ATP binding site [chemical binding]; other site
266834000384	Mg2+ binding site [ion binding]; other site
266834000385	G-X-G motif; other site
266834000386	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
266834000387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834000388	active site
266834000389	phosphorylation site [posttranslational modification]
266834000390	intermolecular recognition site; other site
266834000391	dimerization interface [polypeptide binding]; other site
266834000392	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
266834000393	DNA binding residues [nucleotide binding]
266834000394	Uncharacterized conserved protein [Function unknown]; Region: COG5397
266834000395	5-keto 4-deoxyuronate isomerase [Carbohydrate transport and metabolism]; Region: KduI; COG3717
266834000396	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
266834000397	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834000398	Walker A/P-loop; other site
266834000399	ATP binding site [chemical binding]; other site
266834000400	Q-loop/lid; other site
266834000401	ABC transporter signature motif; other site
266834000402	Walker B; other site
266834000403	D-loop; other site
266834000404	H-loop/switch region; other site
266834000405	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834000406	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834000407	TM-ABC transporter signature motif; other site
266834000408	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
266834000409	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
266834000410	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
266834000411	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
266834000412	NAD(P) binding site [chemical binding]; other site
266834000413	catalytic residues [active]
266834000414	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834000415	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834000416	DNA-binding site [nucleotide binding]; DNA binding site
266834000417	FCD domain; Region: FCD; pfam07729
266834000418	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834000419	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834000420	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
266834000421	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834000422	putative substrate translocation pore; other site
266834000423	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834000424	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
266834000425	glutamate dehydrogenase; Provisional; Region: PRK09414
266834000426	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
266834000427	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
266834000428	NAD(P) binding site [chemical binding]; other site
266834000429	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
266834000430	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
266834000431	Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782
266834000432	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
266834000433	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
266834000434	active site
266834000435	homotetramer interface [polypeptide binding]; other site
266834000436	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
266834000437	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
266834000438	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
266834000439	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834000440	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
266834000441	putative NAD(P) binding site [chemical binding]; other site
266834000442	active site
266834000443	putative substrate binding site [chemical binding]; other site
266834000444	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
266834000445	FAD binding domain; Region: FAD_binding_4; pfam01565
266834000446	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834000447	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834000448	DNA-binding site [nucleotide binding]; DNA binding site
266834000449	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
266834000450	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
266834000451	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
266834000452	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
266834000453	DctM-like transporters; Region: DctM; pfam06808
266834000454	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
266834000455	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
266834000456	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
266834000457	Uncharacterized conserved protein [Function unknown]; Region: COG5482
266834000458	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
266834000459	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
266834000460	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
266834000461	active site
266834000462	catalytic site [active]
266834000463	substrate binding site [chemical binding]; other site
266834000464	Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain.  TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929
266834000465	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
266834000466	FMN binding site [chemical binding]; other site
266834000467	active site
266834000468	homodimer interface [polypeptide binding]; other site
266834000469	putative catalytic residue [active]
266834000470	4Fe-4S cluster binding site [ion binding]; other site
266834000471	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
266834000472	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
266834000473	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
266834000474	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
266834000475	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
266834000476	tetramerization interface [polypeptide binding]; other site
266834000477	NAD(P) binding site [chemical binding]; other site
266834000478	catalytic residues [active]
266834000479	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
266834000480	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
266834000481	active site
266834000482	NAD binding site [chemical binding]; other site
266834000483	metal binding site [ion binding]; metal-binding site
266834000484	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
266834000485	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834000486	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834000487	DNA-binding site [nucleotide binding]; DNA binding site
266834000488	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
266834000489	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834000490	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834000491	Walker A/P-loop; other site
266834000492	ATP binding site [chemical binding]; other site
266834000493	Q-loop/lid; other site
266834000494	ABC transporter signature motif; other site
266834000495	Walker B; other site
266834000496	D-loop; other site
266834000497	H-loop/switch region; other site
266834000498	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834000499	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834000500	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834000501	TM-ABC transporter signature motif; other site
266834000502	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834000503	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311
266834000504	putative ligand binding site [chemical binding]; other site
266834000505	intracellular protease, PfpI family; Region: PfpI; TIGR01382
266834000506	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
266834000507	conserved cys residue [active]
266834000508	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
266834000509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834000510	S-adenosylmethionine binding site [chemical binding]; other site
266834000511	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
266834000512	Methylamine utilisation protein MauE; Region: MauE; pfam07291
266834000513	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
266834000514	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
266834000515	DNA binding residues [nucleotide binding]
266834000516	dimer interface [polypeptide binding]; other site
266834000517	mercury binding site [ion binding]; other site
266834000518	Protein of unknown function (DUF433); Region: DUF433; cl01030
266834000519	TIGR02588 family protein; Region: TIGR02588
266834000520	putative integral membrane protein TIGR02587; Region: TIGR02587
266834000521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834000522	active site
266834000523	phosphorylation site [posttranslational modification]
266834000524	intermolecular recognition site; other site
266834000525	dimerization interface [polypeptide binding]; other site
266834000526	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
266834000527	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834000528	Walker A/P-loop; other site
266834000529	ATP binding site [chemical binding]; other site
266834000530	Q-loop/lid; other site
266834000531	ABC transporter signature motif; other site
266834000532	Walker B; other site
266834000533	D-loop; other site
266834000534	H-loop/switch region; other site
266834000535	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
266834000536	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834000537	Walker A/P-loop; other site
266834000538	ATP binding site [chemical binding]; other site
266834000539	Q-loop/lid; other site
266834000540	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
266834000541	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000542	dimer interface [polypeptide binding]; other site
266834000543	conserved gate region; other site
266834000544	ABC-ATPase subunit interface; other site
266834000545	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834000546	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000547	conserved gate region; other site
266834000548	dimer interface [polypeptide binding]; other site
266834000549	putative PBP binding loops; other site
266834000550	ABC-ATPase subunit interface; other site
266834000551	Cupin domain; Region: Cupin_2; cl17218
266834000552	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834000553	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
266834000554	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
266834000555	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834000556	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
266834000557	dimerization interface [polypeptide binding]; other site
266834000558	substrate binding pocket [chemical binding]; other site
266834000559	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
266834000560	active sites [active]
266834000561	tetramer interface [polypeptide binding]; other site
266834000562	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
266834000563	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834000564	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
266834000565	putative dimerization interface [polypeptide binding]; other site
266834000566	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
266834000567	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834000568	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
266834000569	putative effector binding pocket; other site
266834000570	putative dimerization interface [polypeptide binding]; other site
266834000571	Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512
266834000572	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
266834000573	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
266834000574	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
266834000575	Cupin; Region: Cupin_6; pfam12852
266834000576	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
266834000577	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834000578	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834000579	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
266834000580	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834000581	NAD(P) binding site [chemical binding]; other site
266834000582	active site
266834000583	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
266834000584	Uncharacterized conserved protein [Function unknown]; Region: COG5470
266834000585	Uncharacterized conserved protein [Function unknown]; Region: COG1359
266834000586	short chain dehydrogenase; Provisional; Region: PRK06180
266834000587	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
266834000588	NADP binding site [chemical binding]; other site
266834000589	active site
266834000590	steroid binding site; other site
266834000591	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
266834000592	classical (c) SDRs; Region: SDR_c; cd05233
266834000593	NAD(P) binding site [chemical binding]; other site
266834000594	active site
266834000595	Predicted membrane protein [Function unknown]; Region: COG2259
266834000596	DoxX; Region: DoxX; pfam07681
266834000597	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
266834000598	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834000599	NAD(P) binding site [chemical binding]; other site
266834000600	active site
266834000601	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
266834000602	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834000603	classical (c) SDRs; Region: SDR_c; cd05233
266834000604	NAD(P) binding site [chemical binding]; other site
266834000605	active site
266834000606	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
266834000607	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
266834000608	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
266834000609	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
266834000610	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
266834000611	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834000612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834000613	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
266834000614	substrate binding pocket [chemical binding]; other site
266834000615	dimerization interface [polypeptide binding]; other site
266834000616	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
266834000617	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
266834000618	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
266834000619	Pirin-related protein [General function prediction only]; Region: COG1741
266834000620	Pirin; Region: Pirin; pfam02678
266834000621	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
266834000622	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834000623	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834000624	LysR substrate binding domain; Region: LysR_substrate; pfam03466
266834000625	dimerization interface [polypeptide binding]; other site
266834000626	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834000627	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834000628	Predicted acetyltransferase [General function prediction only]; Region: COG3153
266834000629	Predicted acetyltransferase [General function prediction only]; Region: COG3153
266834000630	Homeodomain-like domain; Region: HTH_23; cl17451
266834000631	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
266834000632	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
266834000633	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834000634	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834000635	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834000636	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834000637	putative effector binding pocket; other site
266834000638	dimerization interface [polypeptide binding]; other site
266834000639	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
266834000640	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834000641	Zn binding site [ion binding]; other site
266834000642	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
266834000643	Zn binding site [ion binding]; other site
266834000644	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
266834000645	Isochorismatase family; Region: Isochorismatase; pfam00857
266834000646	catalytic triad [active]
266834000647	dimer interface [polypeptide binding]; other site
266834000648	conserved cis-peptide bond; other site
266834000649	Protein of unknown function (DUF1427); Region: DUF1427; cl01771
266834000650	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
266834000651	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
266834000652	active site
266834000653	Predicted membrane protein [Function unknown]; Region: COG2259
266834000654	Transmembrane secretion effector; Region: MFS_3; pfam05977
266834000655	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834000656	putative substrate translocation pore; other site
266834000657	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834000658	MULE transposase domain; Region: MULE; pfam10551
266834000659	histidinol-phosphate aminotransferase; Provisional; Region: PRK05166
266834000660	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834000661	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834000662	homodimer interface [polypeptide binding]; other site
266834000663	catalytic residue [active]
266834000664	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834000665	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
266834000666	NAD(P) binding site [chemical binding]; other site
266834000667	active site
266834000668	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
266834000669	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834000670	Walker A/P-loop; other site
266834000671	ATP binding site [chemical binding]; other site
266834000672	Q-loop/lid; other site
266834000673	ABC transporter signature motif; other site
266834000674	Walker B; other site
266834000675	D-loop; other site
266834000676	H-loop/switch region; other site
266834000677	TOBE domain; Region: TOBE_2; pfam08402
266834000678	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
266834000679	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
266834000680	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000681	dimer interface [polypeptide binding]; other site
266834000682	conserved gate region; other site
266834000683	putative PBP binding loops; other site
266834000684	ABC-ATPase subunit interface; other site
266834000685	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834000686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000687	dimer interface [polypeptide binding]; other site
266834000688	conserved gate region; other site
266834000689	putative PBP binding loops; other site
266834000690	ABC-ATPase subunit interface; other site
266834000691	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
266834000692	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
266834000693	NAD binding site [chemical binding]; other site
266834000694	dimerization interface [polypeptide binding]; other site
266834000695	product binding site; other site
266834000696	substrate binding site [chemical binding]; other site
266834000697	zinc binding site [ion binding]; other site
266834000698	catalytic residues [active]
266834000699	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
266834000700	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
266834000701	NAD(P) binding site [chemical binding]; other site
266834000702	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
266834000703	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834000704	DNA-binding site [nucleotide binding]; DNA binding site
266834000705	UTRA domain; Region: UTRA; pfam07702
266834000706	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
266834000707	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
266834000708	phosphate binding site [ion binding]; other site
266834000709	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
266834000710	Uncharacterized conserved protein [Function unknown]; Region: COG5588
266834000711	conserved hypothetical protein; Region: TIGR02118
266834000712	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
266834000713	ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793
266834000714	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
266834000715	active site
266834000716	DNA binding site [nucleotide binding]
266834000717	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
266834000718	DNA binding site [nucleotide binding]
266834000719	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
266834000720	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
266834000721	Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]; Region: COG3285
266834000722	nucleotide binding site [chemical binding]; other site
266834000723	GXWXG protein; Region: GXWXG; pfam14231
266834000724	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
266834000725	Protein of unknown function (DUF768); Region: DUF768; pfam05589
266834000726	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
266834000727	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
266834000728	active site
266834000729	DNA binding site [nucleotide binding]
266834000730	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
266834000731	DNA binding site [nucleotide binding]
266834000732	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
266834000733	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
266834000734	putative DNA binding site [nucleotide binding]; other site
266834000735	putative homodimer interface [polypeptide binding]; other site
266834000736	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
266834000737	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
266834000738	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834000739	PAS domain; Region: PAS_9; pfam13426
266834000740	putative active site [active]
266834000741	heme pocket [chemical binding]; other site
266834000742	Protein of unknown function (DUF1810); Region: DUF1810; cl02370
266834000743	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
266834000744	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
266834000745	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
266834000746	HTH-like domain; Region: HTH_21; pfam13276
266834000747	Integrase core domain; Region: rve; pfam00665
266834000748	Integrase core domain; Region: rve_3; pfam13683
266834000749	Transposase; Region: HTH_Tnp_1; cl17663
266834000750	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834000751	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
266834000752	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
266834000753	oligomeric interface; other site
266834000754	putative active site [active]
266834000755	homodimer interface [polypeptide binding]; other site
266834000756	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834000757	MULE transposase domain; Region: MULE; pfam10551
266834000758	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819
266834000759	putative heme binding site [chemical binding]; other site
266834000760	putative substrate binding site [chemical binding]; other site
266834000761	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834000762	cyclase homology domain; Region: CHD; cd07302
266834000763	nucleotidyl binding site; other site
266834000764	metal binding site [ion binding]; metal-binding site
266834000765	dimer interface [polypeptide binding]; other site
266834000766	Predicted ATPase [General function prediction only]; Region: COG3899
266834000767	AAA ATPase domain; Region: AAA_16; pfam13191
266834000768	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834000769	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
266834000770	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834000771	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
266834000772	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
266834000773	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000774	dimer interface [polypeptide binding]; other site
266834000775	conserved gate region; other site
266834000776	putative PBP binding loops; other site
266834000777	ABC-ATPase subunit interface; other site
266834000778	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
266834000779	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834000780	Walker A/P-loop; other site
266834000781	ATP binding site [chemical binding]; other site
266834000782	Q-loop/lid; other site
266834000783	ABC transporter signature motif; other site
266834000784	Walker B; other site
266834000785	D-loop; other site
266834000786	H-loop/switch region; other site
266834000787	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834000788	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834000789	Walker A/P-loop; other site
266834000790	ATP binding site [chemical binding]; other site
266834000791	Q-loop/lid; other site
266834000792	ABC transporter signature motif; other site
266834000793	Walker B; other site
266834000794	D-loop; other site
266834000795	H-loop/switch region; other site
266834000796	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
266834000797	DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077
266834000798	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
266834000799	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
266834000800	Transposase domain (DUF772); Region: DUF772; pfam05598
266834000801	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
266834000802	formate dehydrogenase; Provisional; Region: PRK07574
266834000803	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
266834000804	dimerization interface [polypeptide binding]; other site
266834000805	ligand binding site [chemical binding]; other site
266834000806	NAD binding site [chemical binding]; other site
266834000807	catalytic site [active]
266834000808	ParB-like nuclease domain; Region: ParBc; cl02129
266834000809	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
266834000810	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
266834000811	active site
266834000812	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
266834000813	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
266834000814	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834000815	catalytic residue [active]
266834000816	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
266834000817	ornithine cyclodeaminase; Validated; Region: PRK06823
266834000818	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
266834000819	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
266834000820	Walker A/P-loop; other site
266834000821	ATP binding site [chemical binding]; other site
266834000822	Q-loop/lid; other site
266834000823	ABC transporter signature motif; other site
266834000824	Walker B; other site
266834000825	D-loop; other site
266834000826	H-loop/switch region; other site
266834000827	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834000828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000829	dimer interface [polypeptide binding]; other site
266834000830	conserved gate region; other site
266834000831	putative PBP binding loops; other site
266834000832	ABC-ATPase subunit interface; other site
266834000833	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834000834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000835	dimer interface [polypeptide binding]; other site
266834000836	conserved gate region; other site
266834000837	putative PBP binding loops; other site
266834000838	ABC-ATPase subunit interface; other site
266834000839	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
266834000840	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834000841	substrate binding pocket [chemical binding]; other site
266834000842	membrane-bound complex binding site; other site
266834000843	hinge residues; other site
266834000844	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
266834000845	YheO-like PAS domain; Region: PAS_6; pfam08348
266834000846	HTH domain; Region: HTH_22; pfam13309
266834000847	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834000848	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
266834000849	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
266834000850	dimerization interface [polypeptide binding]; other site
266834000851	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
266834000852	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
266834000853	Zn2+ binding site [ion binding]; other site
266834000854	Mg2+ binding site [ion binding]; other site
266834000855	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834000856	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000857	dimer interface [polypeptide binding]; other site
266834000858	conserved gate region; other site
266834000859	putative PBP binding loops; other site
266834000860	ABC-ATPase subunit interface; other site
266834000861	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834000862	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000863	dimer interface [polypeptide binding]; other site
266834000864	conserved gate region; other site
266834000865	putative PBP binding loops; other site
266834000866	ABC-ATPase subunit interface; other site
266834000867	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
266834000868	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834000869	substrate binding pocket [chemical binding]; other site
266834000870	membrane-bound complex binding site; other site
266834000871	hinge residues; other site
266834000872	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
266834000873	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
266834000874	Walker A/P-loop; other site
266834000875	ATP binding site [chemical binding]; other site
266834000876	Q-loop/lid; other site
266834000877	ABC transporter signature motif; other site
266834000878	Walker B; other site
266834000879	D-loop; other site
266834000880	H-loop/switch region; other site
266834000881	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
266834000882	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
266834000883	putative ligand binding site [chemical binding]; other site
266834000884	NAD binding site [chemical binding]; other site
266834000885	catalytic site [active]
266834000886	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
266834000887	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
266834000888	putative NAD(P) binding site [chemical binding]; other site
266834000889	catalytic Zn binding site [ion binding]; other site
266834000890	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
266834000891	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
266834000892	NADP binding site [chemical binding]; other site
266834000893	homodimer interface [polypeptide binding]; other site
266834000894	active site
266834000895	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
266834000896	AAA domain; Region: AAA_33; pfam13671
266834000897	ATP-binding site [chemical binding]; other site
266834000898	Gluconate-6-phosphate binding site [chemical binding]; other site
266834000899	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
266834000900	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
266834000901	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
266834000902	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
266834000903	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
266834000904	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
266834000905	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
266834000906	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
266834000907	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000908	dimer interface [polypeptide binding]; other site
266834000909	conserved gate region; other site
266834000910	putative PBP binding loops; other site
266834000911	ABC-ATPase subunit interface; other site
266834000912	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000913	dimer interface [polypeptide binding]; other site
266834000914	conserved gate region; other site
266834000915	putative PBP binding loops; other site
266834000916	ABC-ATPase subunit interface; other site
266834000917	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
266834000918	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
266834000919	Walker A/P-loop; other site
266834000920	ATP binding site [chemical binding]; other site
266834000921	Q-loop/lid; other site
266834000922	ABC transporter signature motif; other site
266834000923	Walker B; other site
266834000924	D-loop; other site
266834000925	H-loop/switch region; other site
266834000926	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
266834000927	catalytic core [active]
266834000928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834000929	S-adenosylmethionine binding site [chemical binding]; other site
266834000930	AsnC family; Region: AsnC_trans_reg; pfam01037
266834000931	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834000932	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
266834000933	SnoaL-like domain; Region: SnoaL_3; pfam13474
266834000934	PRC-barrel domain; Region: PRC; pfam05239
266834000935	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
266834000936	putative active site [active]
266834000937	homotetrameric interface [polypeptide binding]; other site
266834000938	metal binding site [ion binding]; metal-binding site
266834000939	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
266834000940	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151
266834000941	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
266834000942	active site
266834000943	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
266834000944	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834000945	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834000946	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
266834000947	putative effector binding pocket; other site
266834000948	putative dimerization interface [polypeptide binding]; other site
266834000949	Uncharacterized conserved protein [Function unknown]; Region: COG1359
266834000950	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
266834000951	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
266834000952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4334
266834000953	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834000954	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834000955	active site
266834000956	catalytic tetrad [active]
266834000957	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
266834000958	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
266834000959	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
266834000960	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
266834000961	CoA binding site [chemical binding]; other site
266834000962	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834000963	cyclase homology domain; Region: CHD; cd07302
266834000964	nucleotidyl binding site; other site
266834000965	metal binding site [ion binding]; metal-binding site
266834000966	dimer interface [polypeptide binding]; other site
266834000967	Predicted integral membrane protein [Function unknown]; Region: COG5616
266834000968	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834000969	TPR motif; other site
266834000970	binding surface
266834000971	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
266834000972	Uncharacterized conserved protein [Function unknown]; Region: COG3246
266834000973	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
266834000974	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
266834000975	dimerization interface [polypeptide binding]; other site
266834000976	ligand binding site [chemical binding]; other site
266834000977	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
266834000978	dimerization interface [polypeptide binding]; other site
266834000979	PAS fold; Region: PAS_7; pfam12860
266834000980	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834000981	cyclase homology domain; Region: CHD; cd07302
266834000982	nucleotidyl binding site; other site
266834000983	metal binding site [ion binding]; metal-binding site
266834000984	dimer interface [polypeptide binding]; other site
266834000985	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
266834000986	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
266834000987	Walker A/P-loop; other site
266834000988	ATP binding site [chemical binding]; other site
266834000989	Q-loop/lid; other site
266834000990	ABC transporter signature motif; other site
266834000991	Walker B; other site
266834000992	D-loop; other site
266834000993	H-loop/switch region; other site
266834000994	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
266834000995	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834000996	putative PBP binding loops; other site
266834000997	dimer interface [polypeptide binding]; other site
266834000998	ABC-ATPase subunit interface; other site
266834000999	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
266834001000	NMT1-like family; Region: NMT1_2; pfam13379
266834001001	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
266834001002	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
266834001003	HipA N-terminal domain; Region: Couple_hipA; pfam13657
266834001004	HipA-like N-terminal domain; Region: HipA_N; pfam07805
266834001005	HipA-like C-terminal domain; Region: HipA_C; pfam07804
266834001006	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834001007	non-specific DNA binding site [nucleotide binding]; other site
266834001008	salt bridge; other site
266834001009	sequence-specific DNA binding site [nucleotide binding]; other site
266834001010	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
266834001011	Predicted integral membrane protein [Function unknown]; Region: COG5616
266834001012	TPR repeat; Region: TPR_11; pfam13414
266834001013	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834001014	binding surface
266834001015	TPR motif; other site
266834001016	Predicted periplasmic protein [Function unknown]; Region: COG3900
266834001017	Uncharacterized conserved protein [Function unknown]; Region: COG5361
266834001018	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
266834001019	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
266834001020	Uncharacterized conserved protein [Function unknown]; Region: COG5361
266834001021	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
266834001022	Uncharacterized conserved protein [Function unknown]; Region: COG5361
266834001023	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
266834001024	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
266834001025	Low-spin heme binding site [chemical binding]; other site
266834001026	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
266834001027	Putative water exit pathway; other site
266834001028	Binuclear center (active site) [active]
266834001029	Putative proton exit pathway; other site
266834001030	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
266834001031	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
266834001032	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
266834001033	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
266834001034	Cytochrome c; Region: Cytochrom_C; pfam00034
266834001035	Cytochrome c; Region: Cytochrom_C; pfam00034
266834001036	Predicted integral membrane protein [Function unknown]; Region: COG5473
266834001037	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
266834001038	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
266834001039	metal-binding site [ion binding]
266834001040	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
266834001041	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834001042	motif II; other site
266834001043	Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197
266834001044	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
266834001045	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
266834001046	ligand binding site [chemical binding]; other site
266834001047	Predicted periplasmic protein [Function unknown]; Region: COG3900
266834001048	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
266834001049	amphipathic channel; other site
266834001050	Asn-Pro-Ala signature motifs; other site
266834001051	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
266834001052	Mechanosensitive ion channel; Region: MS_channel; pfam00924
266834001053	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
266834001054	FOG: CBS domain [General function prediction only]; Region: COG0517
266834001055	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
266834001056	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
266834001057	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
266834001058	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
266834001059	BA14K-like protein; Region: BA14K; pfam07886
266834001060	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
266834001061	Transposase; Region: DDE_Tnp_ISL3; pfam01610
266834001062	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
266834001063	HTH DNA binding domain; Region: HTH_13; pfam11972
266834001064	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
266834001065	Helix-turn-helix domain; Region: HTH_38; pfam13936
266834001066	DNA-binding interface [nucleotide binding]; DNA binding site
266834001067	Integrase core domain; Region: rve; pfam00665
266834001068	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
266834001069	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
266834001070	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
266834001071	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
266834001072	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
266834001073	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
266834001074	ligand binding site [chemical binding]; other site
266834001075	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
266834001076	putative switch regulator; other site
266834001077	non-specific DNA interactions [nucleotide binding]; other site
266834001078	DNA binding site [nucleotide binding]
266834001079	sequence specific DNA binding site [nucleotide binding]; other site
266834001080	putative cAMP binding site [chemical binding]; other site
266834001081	Predicted integral membrane protein [Function unknown]; Region: COG5616
266834001082	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834001083	TPR motif; other site
266834001084	binding surface
266834001085	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
266834001086	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
266834001087	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834001088	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
266834001089	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834001090	MULE transposase domain; Region: MULE; pfam10551
266834001091	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
266834001092	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
266834001093	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
266834001094	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834001095	substrate binding pocket [chemical binding]; other site
266834001096	membrane-bound complex binding site; other site
266834001097	hinge residues; other site
266834001098	putrescine transporter; Provisional; Region: potE; PRK10655
266834001099	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
266834001100	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
266834001101	ornithine decarboxylase; Provisional; Region: PRK13578
266834001102	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
266834001103	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
266834001104	catalytic residue [active]
266834001105	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
266834001106	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
266834001107	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
266834001108	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
266834001109	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
266834001110	catalytic residue [active]
266834001111	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
266834001112	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: COG3965
266834001113	arginine:agmatin antiporter; Provisional; Region: PRK10644
266834001114	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
266834001115	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
266834001116	arginine deiminase; Provisional; Region: PRK01388
266834001117	ornithine carbamoyltransferase; Validated; Region: PRK02102
266834001118	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
266834001119	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
266834001120	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
266834001121	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
266834001122	putative substrate binding site [chemical binding]; other site
266834001123	nucleotide binding site [chemical binding]; other site
266834001124	nucleotide binding site [chemical binding]; other site
266834001125	homodimer interface [polypeptide binding]; other site
266834001126	Ion channel; Region: Ion_trans_2; pfam07885
266834001127	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
266834001128	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
266834001129	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
266834001130	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
266834001131	inhibitor site; inhibition site
266834001132	active site
266834001133	dimer interface [polypeptide binding]; other site
266834001134	catalytic residue [active]
266834001135	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
266834001136	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
266834001137	active site pocket [active]
266834001138	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834001139	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834001140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834001141	dimer interface [polypeptide binding]; other site
266834001142	conserved gate region; other site
266834001143	putative PBP binding loops; other site
266834001144	ABC-ATPase subunit interface; other site
266834001145	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834001146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834001147	dimer interface [polypeptide binding]; other site
266834001148	conserved gate region; other site
266834001149	putative PBP binding loops; other site
266834001150	ABC-ATPase subunit interface; other site
266834001151	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834001152	Walker A/P-loop; other site
266834001153	ATP binding site [chemical binding]; other site
266834001154	ABC transporter; Region: ABC_tran; pfam00005
266834001155	Q-loop/lid; other site
266834001156	ABC transporter signature motif; other site
266834001157	Walker B; other site
266834001158	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
266834001159	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834001160	TOBE domain; Region: TOBE_2; pfam08402
266834001161	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834001162	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834001163	NAD(P) binding site [chemical binding]; other site
266834001164	active site
266834001165	Transcriptional regulator [Transcription]; Region: IclR; COG1414
266834001166	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
266834001167	Bacterial transcriptional regulator; Region: IclR; pfam01614
266834001168	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
266834001169	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
266834001170	classical (c) SDRs; Region: SDR_c; cd05233
266834001171	NAD(P) binding site [chemical binding]; other site
266834001172	active site
266834001173	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834001174	Transposase; Region: HTH_Tnp_1; cl17663
266834001175	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834001176	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
266834001177	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834001178	Coenzyme A binding pocket [chemical binding]; other site
266834001179	Uncharacterized conserved protein [Function unknown]; Region: COG5556
266834001180	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
266834001181	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
266834001182	DNA-binding site [nucleotide binding]; DNA binding site
266834001183	RNA-binding motif; other site
266834001184	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
266834001185	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
266834001186	ring oligomerisation interface [polypeptide binding]; other site
266834001187	ATP/Mg binding site [chemical binding]; other site
266834001188	stacking interactions; other site
266834001189	hinge regions; other site
266834001190	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
266834001191	oligomerisation interface [polypeptide binding]; other site
266834001192	mobile loop; other site
266834001193	roof hairpin; other site
266834001194	Predicted transcriptional regulator [Transcription]; Region: COG4957
266834001195	Integrase core domain; Region: rve_3; pfam13683
266834001196	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
266834001197	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834001198	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834001199	dimerization interface [polypeptide binding]; other site
266834001200	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
266834001201	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
266834001202	[2Fe-2S] cluster binding site [ion binding]; other site
266834001203	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
266834001204	putative alpha subunit interface [polypeptide binding]; other site
266834001205	putative active site [active]
266834001206	putative substrate binding site [chemical binding]; other site
266834001207	Fe binding site [ion binding]; other site
266834001208	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
266834001209	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
266834001210	FAD binding pocket [chemical binding]; other site
266834001211	FAD binding motif [chemical binding]; other site
266834001212	phosphate binding motif [ion binding]; other site
266834001213	beta-alpha-beta structure motif; other site
266834001214	NAD binding pocket [chemical binding]; other site
266834001215	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834001216	catalytic loop [active]
266834001217	iron binding site [ion binding]; other site
266834001218	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
266834001219	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834001220	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834001221	The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462
266834001222	putative substrate binding pocket [chemical binding]; other site
266834001223	putative dimerization interface [polypeptide binding]; other site
266834001224	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
266834001225	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
266834001226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
266834001227	dimerization interface [polypeptide binding]; other site
266834001228	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
266834001229	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
266834001230	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
266834001231	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
266834001232	ligand binding site [chemical binding]; other site
266834001233	flexible hinge region; other site
266834001234	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
266834001235	putative switch regulator; other site
266834001236	non-specific DNA interactions [nucleotide binding]; other site
266834001237	DNA binding site [nucleotide binding]
266834001238	sequence specific DNA binding site [nucleotide binding]; other site
266834001239	putative cAMP binding site [chemical binding]; other site
266834001240	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
266834001241	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
266834001242	Low-spin heme binding site [chemical binding]; other site
266834001243	Putative water exit pathway; other site
266834001244	Binuclear center (active site) [active]
266834001245	Putative proton exit pathway; other site
266834001246	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
266834001247	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
266834001248	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
266834001249	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
266834001250	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
266834001251	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
266834001252	maltose O-acetyltransferase; Provisional; Region: PRK10092
266834001253	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
266834001254	active site
266834001255	substrate binding site [chemical binding]; other site
266834001256	trimer interface [polypeptide binding]; other site
266834001257	CoA binding site [chemical binding]; other site
266834001258	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
266834001259	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834001260	S-adenosylmethionine binding site [chemical binding]; other site
266834001261	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
266834001262	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
266834001263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834001264	Walker A motif; other site
266834001265	ATP binding site [chemical binding]; other site
266834001266	Walker B motif; other site
266834001267	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
266834001268	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834001269	Winged helix-turn helix; Region: HTH_29; pfam13551
266834001270	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
266834001271	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
266834001272	catalytic residues [active]
266834001273	catalytic nucleophile [active]
266834001274	Recombinase; Region: Recombinase; pfam07508
266834001275	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
266834001276	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
266834001277	DNA binding residues [nucleotide binding]
266834001278	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
266834001279	Integrase core domain; Region: rve; pfam00665
266834001280	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834001281	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834001282	DNA-binding site [nucleotide binding]; DNA binding site
266834001283	FCD domain; Region: FCD; pfam07729
266834001284	Amino acid synthesis; Region: AA_synth; pfam06684
266834001285	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
266834001286	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
266834001287	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
266834001288	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
266834001289	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
266834001290	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
266834001291	NAD(P) binding site [chemical binding]; other site
266834001292	catalytic residues [active]
266834001293	NIPSNAP; Region: NIPSNAP; pfam07978
266834001294	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
266834001295	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
266834001296	ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176
266834001297	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834001298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834001299	dimer interface [polypeptide binding]; other site
266834001300	conserved gate region; other site
266834001301	putative PBP binding loops; other site
266834001302	ABC-ATPase subunit interface; other site
266834001303	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
266834001304	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834001305	Walker A/P-loop; other site
266834001306	ATP binding site [chemical binding]; other site
266834001307	Q-loop/lid; other site
266834001308	ABC transporter signature motif; other site
266834001309	Walker B; other site
266834001310	D-loop; other site
266834001311	H-loop/switch region; other site
266834001312	TOBE domain; Region: TOBE_2; pfam08402
266834001313	succinic semialdehyde dehydrogenase; Region: PLN02278
266834001314	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
266834001315	tetramerization interface [polypeptide binding]; other site
266834001316	NAD(P) binding site [chemical binding]; other site
266834001317	catalytic residues [active]
266834001318	Transposase; Region: HTH_Tnp_1; cl17663
266834001319	Nitrogen fixation protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NifU; COG5554
266834001320	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
266834001321	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
266834001322	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
266834001323	FeS/SAM binding site; other site
266834001324	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
266834001325	Nif-specific regulatory protein; Region: nifA; TIGR01817
266834001326	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
266834001327	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834001328	Walker A motif; other site
266834001329	ATP binding site [chemical binding]; other site
266834001330	Walker B motif; other site
266834001331	arginine finger; other site
266834001332	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
266834001333	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
266834001334	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
266834001335	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
266834001336	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
266834001337	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
266834001338	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
266834001339	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
266834001340	Ligand binding site [chemical binding]; other site
266834001341	Electron transfer flavoprotein domain; Region: ETF; pfam01012
266834001342	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
266834001343	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
266834001344	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
266834001345	Nucleotide-binding sites [chemical binding]; other site
266834001346	Walker A motif; other site
266834001347	Switch I region of nucleotide binding site; other site
266834001348	Fe4S4 binding sites [ion binding]; other site
266834001349	Switch II region of nucleotide binding site; other site
266834001350	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
266834001351	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
266834001352	MoFe protein alpha/beta subunit interactions; other site
266834001353	Alpha subunit P cluster binding residues; other site
266834001354	FeMoco binding residues [chemical binding]; other site
266834001355	MoFe protein alpha subunit/Fe protein contacts; other site
266834001356	MoFe protein dimer/ dimer interactions; other site
266834001357	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
266834001358	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
266834001359	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
266834001360	MoFe protein beta/alpha subunit interactions; other site
266834001361	Beta subunit P cluster binding residues; other site
266834001362	MoFe protein beta subunit/Fe protein contacts; other site
266834001363	MoFe protein dimer/ dimer interactions; other site
266834001364	nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478
266834001365	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
266834001366	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
266834001367	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5420
266834001368	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
266834001369	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
266834001370	Exopolysaccharide production repressor; Region: SyrA; pfam11089
266834001371	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834001372	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834001373	The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462
266834001374	putative substrate binding pocket [chemical binding]; other site
266834001375	putative dimerization interface [polypeptide binding]; other site
266834001376	Transposase; Region: HTH_Tnp_1; pfam01527
266834001377	Integrase core domain; Region: rve; pfam00665
266834001378	Integrase core domain; Region: rve_3; cl15866
266834001379	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834001380	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834001381	The C-terminal substrate binding of LysR-type symbiotic regulator SyrM, which activates expression of nodulation gene NodD3, contains the type 2 periplasmic binding fold; Region: PBP2_SyrM; cd08467
266834001382	putative substrate binding pocket [chemical binding]; other site
266834001383	putative dimerization interface [polypeptide binding]; other site
266834001384	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
266834001385	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
266834001386	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
266834001387	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
266834001388	dimer interface [polypeptide binding]; other site
266834001389	active site
266834001390	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
266834001391	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
266834001392	NAD(P) binding site [chemical binding]; other site
266834001393	homotetramer interface [polypeptide binding]; other site
266834001394	homodimer interface [polypeptide binding]; other site
266834001395	active site
266834001396	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
266834001397	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
266834001398	Active Sites [active]
266834001399	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
266834001400	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
266834001401	CysD dimerization site [polypeptide binding]; other site
266834001402	G1 box; other site
266834001403	putative GEF interaction site [polypeptide binding]; other site
266834001404	GTP/Mg2+ binding site [chemical binding]; other site
266834001405	Switch I region; other site
266834001406	G2 box; other site
266834001407	G3 box; other site
266834001408	Switch II region; other site
266834001409	G4 box; other site
266834001410	G5 box; other site
266834001411	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
266834001412	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
266834001413	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
266834001414	ligand-binding site [chemical binding]; other site
266834001415	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
266834001416	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834001417	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
266834001418	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
266834001419	ABC-2 type transporter, NodJ family; Region: nodJ; TIGR01291
266834001420	nodulation factor exporter subunit NodI; Provisional; Region: PRK13536
266834001421	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
266834001422	Walker A/P-loop; other site
266834001423	ATP binding site [chemical binding]; other site
266834001424	Q-loop/lid; other site
266834001425	ABC transporter signature motif; other site
266834001426	Walker B; other site
266834001427	D-loop; other site
266834001428	H-loop/switch region; other site
266834001429	chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242
266834001430	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
266834001431	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
266834001432	DXD motif; other site
266834001433	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
266834001434	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
266834001435	Nodulation protein A (NodA); Region: NodA; pfam02474
266834001436	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834001437	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834001438	The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462
266834001439	putative substrate binding pocket [chemical binding]; other site
266834001440	putative dimerization interface [polypeptide binding]; other site
266834001441	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
266834001442	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
266834001443	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
266834001444	putative active site [active]
266834001445	putative catalytic site [active]
266834001446	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
266834001447	Protein export membrane protein; Region: SecD_SecF; cl14618
266834001448	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
266834001449	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834001450	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
266834001451	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
266834001452	glutaminase active site [active]
266834001453	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
266834001454	dimer interface [polypeptide binding]; other site
266834001455	active site
266834001456	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
266834001457	dimer interface [polypeptide binding]; other site
266834001458	active site
266834001459	Uncharacterized conserved protein [Function unknown]; Region: COG2135
266834001460	Uncharacterized conserved protein [Function unknown]; Region: COG2135
266834001461	Y-family of DNA polymerases; Region: PolY; cl12025
266834001462	DNA binding site [nucleotide binding]
266834001463	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
266834001464	active site
266834001465	Uncharacterized conserved protein [Function unknown]; Region: COG4544
266834001466	DNA Polymerase Y-family; Region: PolY_like; cd03468
266834001467	active site
266834001468	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
266834001469	DNA binding site [nucleotide binding]
266834001470	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
266834001471	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
266834001472	putative active site [active]
266834001473	putative PHP Thumb interface [polypeptide binding]; other site
266834001474	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
266834001475	generic binding surface I; other site
266834001476	generic binding surface II; other site
266834001477	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
266834001478	Antirestriction protein; Region: Antirestrict; pfam03230
266834001479	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
266834001480	Helicase_C-like; Region: Helicase_C_4; pfam13871
266834001481	Toprim domain; Region: Toprim_3; pfam13362
266834001482	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
266834001483	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
266834001484	putative active site [active]
266834001485	Uncharacterized conserved protein [Function unknown]; Region: COG5489
266834001486	conjugal transfer coupling protein TraG; Provisional; Region: PRK13822
266834001487	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
266834001488	Walker A motif; other site
266834001489	ATP binding site [chemical binding]; other site
266834001490	Walker B motif; other site
266834001491	Conjugal transfer protein TraD; Region: TraD; pfam06412
266834001492	TraC-like protein; Region: TraC; pfam07820
266834001493	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
266834001494	MobA/MobL family; Region: MobA_MobL; pfam03389
266834001495	AAA domain; Region: AAA_30; pfam13604
266834001496	Family description; Region: UvrD_C_2; pfam13538
266834001497	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
266834001498	Mechanosensitive ion channel; Region: MS_channel; pfam00924
266834001499	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834001500	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834001501	dimer interface [polypeptide binding]; other site
266834001502	phosphorylation site [posttranslational modification]
266834001503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834001504	ATP binding site [chemical binding]; other site
266834001505	Mg2+ binding site [ion binding]; other site
266834001506	G-X-G motif; other site
266834001507	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
266834001508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834001509	active site
266834001510	phosphorylation site [posttranslational modification]
266834001511	intermolecular recognition site; other site
266834001512	dimerization interface [polypeptide binding]; other site
266834001513	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834001514	DNA binding residues [nucleotide binding]
266834001515	dimerization interface [polypeptide binding]; other site
266834001516	Response regulator receiver domain; Region: Response_reg; pfam00072
266834001517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834001518	active site
266834001519	phosphorylation site [posttranslational modification]
266834001520	intermolecular recognition site; other site
266834001521	dimerization interface [polypeptide binding]; other site
266834001522	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
266834001523	Sulfatase; Region: Sulfatase; pfam00884
266834001524	Sulfatase; Region: Sulfatase; cl17466
266834001525	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
266834001526	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834001527	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834001528	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834001529	dimer interface [polypeptide binding]; other site
266834001530	conserved gate region; other site
266834001531	putative PBP binding loops; other site
266834001532	ABC-ATPase subunit interface; other site
266834001533	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
266834001534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834001535	dimer interface [polypeptide binding]; other site
266834001536	conserved gate region; other site
266834001537	putative PBP binding loops; other site
266834001538	ABC-ATPase subunit interface; other site
266834001539	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
266834001540	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834001541	Walker A/P-loop; other site
266834001542	ATP binding site [chemical binding]; other site
266834001543	Q-loop/lid; other site
266834001544	ABC transporter signature motif; other site
266834001545	Walker B; other site
266834001546	D-loop; other site
266834001547	H-loop/switch region; other site
266834001548	TOBE domain; Region: TOBE_2; pfam08402
266834001549	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834001550	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834001551	DNA-binding site [nucleotide binding]; DNA binding site
266834001552	FCD domain; Region: FCD; pfam07729
266834001553	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
266834001554	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834001555	inhibitor-cofactor binding pocket; inhibition site
266834001556	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834001557	catalytic residue [active]
266834001558	acetolactate synthase catalytic subunit; Validated; Region: PRK06112
266834001559	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
266834001560	PYR/PP interface [polypeptide binding]; other site
266834001561	dimer interface [polypeptide binding]; other site
266834001562	TPP binding site [chemical binding]; other site
266834001563	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
266834001564	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
266834001565	TPP-binding site [chemical binding]; other site
266834001566	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
266834001567	classical (c) SDRs; Region: SDR_c; cd05233
266834001568	NAD(P) binding site [chemical binding]; other site
266834001569	active site
266834001570	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834001571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834001572	active site
266834001573	phosphorylation site [posttranslational modification]
266834001574	intermolecular recognition site; other site
266834001575	dimerization interface [polypeptide binding]; other site
266834001576	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834001577	DNA binding site [nucleotide binding]
266834001578	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
266834001579	active site
266834001580	NTP binding site [chemical binding]; other site
266834001581	metal binding triad [ion binding]; metal-binding site
266834001582	antibiotic binding site [chemical binding]; other site
266834001583	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
266834001584	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834001585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
266834001586	active site
266834001587	phosphorylation site [posttranslational modification]
266834001588	intermolecular recognition site; other site
266834001589	dimerization interface [polypeptide binding]; other site
266834001590	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834001591	DNA binding site [nucleotide binding]
266834001592	hypothetical protein; Provisional; Region: PRK07505
266834001593	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
266834001594	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
266834001595	catalytic residue [active]
266834001596	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834001597	MULE transposase domain; Region: MULE; pfam10551
266834001598	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
266834001599	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
266834001600	DNA-binding interface [nucleotide binding]; DNA binding site
266834001601	Homeodomain-like domain; Region: HTH_32; pfam13565
266834001602	Integrase core domain; Region: rve; pfam00665
266834001603	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
266834001604	oligomeric interface; other site
266834001605	putative active site [active]
266834001606	homodimer interface [polypeptide binding]; other site
266834001607	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834001608	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834001609	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834001610	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
266834001611	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834001612	MULE transposase domain; Region: MULE; pfam10551
266834001613	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834001614	MULE transposase domain; Region: MULE; pfam10551
266834001615	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
266834001616	HWE histidine kinase; Region: HWE_HK; pfam07536
266834001617	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
266834001618	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
266834001619	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
266834001620	Predicted metal-binding protein [General function prediction only]; Region: COG3019
266834001621	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
266834001622	metal-binding site [ion binding]
266834001623	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
266834001624	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
266834001625	ligand binding site [chemical binding]; other site
266834001626	flexible hinge region; other site
266834001627	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
266834001628	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
266834001629	metal-binding site [ion binding]
266834001630	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
266834001631	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
266834001632	metal-binding site [ion binding]
266834001633	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
266834001634	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834001635	motif II; other site
266834001636	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
266834001637	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
266834001638	DNA binding residues [nucleotide binding]
266834001639	dimer interface [polypeptide binding]; other site
266834001640	copper binding site [ion binding]; other site
266834001641	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
266834001642	Cytochrome C' Region: Cytochrom_C_2; cl01610
266834001643	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
266834001644	Predicted membrane protein [Function unknown]; Region: COG1238
266834001645	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
266834001646	HTH-like domain; Region: HTH_21; pfam13276
266834001647	Integrase core domain; Region: rve; pfam00665
266834001648	Integrase core domain; Region: rve_3; pfam13683
266834001649	Transposase; Region: HTH_Tnp_1; cl17663
266834001650	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834001651	Predicted membrane protein [Function unknown]; Region: COG1238
266834001652	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
266834001653	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
266834001654	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
266834001655	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
266834001656	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
266834001657	Uncharacterized conserved protein [Function unknown]; Region: COG5569
266834001658	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834001659	cyclase homology domain; Region: CHD; cd07302
266834001660	nucleotidyl binding site; other site
266834001661	metal binding site [ion binding]; metal-binding site
266834001662	dimer interface [polypeptide binding]; other site
266834001663	Predicted transporter component [General function prediction only]; Region: COG2391
266834001664	Sulphur transport; Region: Sulf_transp; pfam04143
266834001665	Predicted transporter component [General function prediction only]; Region: COG2391
266834001666	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
266834001667	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834001668	dimerization interface [polypeptide binding]; other site
266834001669	putative DNA binding site [nucleotide binding]; other site
266834001670	putative Zn2+ binding site [ion binding]; other site
266834001671	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453
266834001672	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
266834001673	Uncharacterized conserved protein [Function unknown]; Region: COG5361
266834001674	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
266834001675	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
266834001676	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
266834001677	Uncharacterized conserved protein [Function unknown]; Region: COG5361
266834001678	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
266834001679	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
266834001680	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
266834001681	ligand binding site [chemical binding]; other site
266834001682	flexible hinge region; other site
266834001683	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
266834001684	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
266834001685	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
266834001686	Integrase core domain; Region: rve; pfam00665
266834001687	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
266834001688	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
266834001689	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
266834001690	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834001691	Walker A motif; other site
266834001692	ATP binding site [chemical binding]; other site
266834001693	Walker B motif; other site
266834001694	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
266834001695	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834001696	non-specific DNA binding site [nucleotide binding]; other site
266834001697	salt bridge; other site
266834001698	sequence-specific DNA binding site [nucleotide binding]; other site
266834001699	Cupin domain; Region: Cupin_2; pfam07883
266834001700	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
266834001701	Fasciclin domain; Region: Fasciclin; pfam02469
266834001702	Uncharacterized conserved protein [Function unknown]; Region: COG2155
266834001703	TspO/MBR family; Region: TspO_MBR; pfam03073
266834001704	LTXXQ motif family protein; Region: LTXXQ; pfam07813
266834001705	putative phosphoketolase; Provisional; Region: PRK05261
266834001706	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
266834001707	TPP-binding site; other site
266834001708	XFP C-terminal domain; Region: XFP_C; pfam09363
266834001709	FOG: CBS domain [General function prediction only]; Region: COG0517
266834001710	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
266834001711	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
266834001712	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
266834001713	Soluble P-type ATPase [General function prediction only]; Region: COG4087
266834001714	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
266834001715	hydrophobic ligand binding site; other site
266834001716	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
266834001717	Ligand Binding Site [chemical binding]; other site
266834001718	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
266834001719	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
266834001720	Cytochrome c; Region: Cytochrom_C; pfam00034
266834001721	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
266834001722	Ligand Binding Site [chemical binding]; other site
266834001723	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
266834001724	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834001725	cyclase homology domain; Region: CHD; cd07302
266834001726	nucleotidyl binding site; other site
266834001727	metal binding site [ion binding]; metal-binding site
266834001728	dimer interface [polypeptide binding]; other site
266834001729	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
266834001730	Cytochrome c; Region: Cytochrom_C; pfam00034
266834001731	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834001732	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
266834001733	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
266834001734	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
266834001735	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
266834001736	putative dimer interface [polypeptide binding]; other site
266834001737	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
266834001738	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
266834001739	Walker A/P-loop; other site
266834001740	ATP binding site [chemical binding]; other site
266834001741	Q-loop/lid; other site
266834001742	ABC transporter signature motif; other site
266834001743	Walker B; other site
266834001744	D-loop; other site
266834001745	H-loop/switch region; other site
266834001746	FtsX-like permease family; Region: FtsX; pfam02687
266834001747	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
266834001748	FtsX-like permease family; Region: FtsX; pfam02687
266834001749	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
266834001750	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834001751	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
266834001752	Peptidase family M50; Region: Peptidase_M50; pfam02163
266834001753	active site
266834001754	putative substrate binding region [chemical binding]; other site
266834001755	FOG: CBS domain [General function prediction only]; Region: COG0517
266834001756	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639
266834001757	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
266834001758	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
266834001759	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
266834001760	protein binding site [polypeptide binding]; other site
266834001761	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
266834001762	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
266834001763	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
266834001764	Beta-Casp domain; Region: Beta-Casp; smart01027
266834001765	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
266834001766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
266834001767	active site
266834001768	dimerization interface [polypeptide binding]; other site
266834001769	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834001770	DNA binding site [nucleotide binding]
266834001771	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834001772	active site
266834001773	phosphorylation site [posttranslational modification]
266834001774	intermolecular recognition site; other site
266834001775	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
266834001776	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
266834001777	ligand binding site [chemical binding]; other site
266834001778	flexible hinge region; other site
266834001779	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
266834001780	putative switch regulator; other site
266834001781	non-specific DNA interactions [nucleotide binding]; other site
266834001782	DNA binding site [nucleotide binding]
266834001783	sequence specific DNA binding site [nucleotide binding]; other site
266834001784	putative cAMP binding site [chemical binding]; other site
266834001785	PAS domain S-box; Region: sensory_box; TIGR00229
266834001786	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834001787	putative active site [active]
266834001788	heme pocket [chemical binding]; other site
266834001789	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834001790	dimer interface [polypeptide binding]; other site
266834001791	phosphorylation site [posttranslational modification]
266834001792	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834001793	ATP binding site [chemical binding]; other site
266834001794	Mg2+ binding site [ion binding]; other site
266834001795	G-X-G motif; other site
266834001796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834001797	active site
266834001798	phosphorylation site [posttranslational modification]
266834001799	intermolecular recognition site; other site
266834001800	dimerization interface [polypeptide binding]; other site
266834001801	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
266834001802	CoA binding domain; Region: CoA_binding_2; pfam13380
266834001803	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
266834001804	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
266834001805	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
266834001806	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834001807	Coenzyme A binding pocket [chemical binding]; other site
266834001808	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
266834001809	Ligand Binding Site [chemical binding]; other site
266834001810	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
266834001811	Ligand Binding Site [chemical binding]; other site
266834001812	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
266834001813	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
266834001814	BON domain; Region: BON; pfam04972
266834001815	BON domain; Region: BON; pfam04972
266834001816	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
266834001817	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
266834001818	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
266834001819	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
266834001820	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834001821	motif II; other site
266834001822	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
266834001823	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
266834001824	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
266834001825	tetramer interface [polypeptide binding]; other site
266834001826	catalytic Zn binding site [ion binding]; other site
266834001827	NADP binding site [chemical binding]; other site
266834001828	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
266834001829	Ligand Binding Site [chemical binding]; other site
266834001830	Predicted membrane protein [Function unknown]; Region: COG3174
266834001831	Predicted membrane protein [Function unknown]; Region: COG3174
266834001832	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
266834001833	Predicted membrane protein [Function unknown]; Region: COG3174
266834001834	Predicted membrane protein [Function unknown]; Region: COG3619
266834001835	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
266834001836	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
266834001837	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
266834001838	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
266834001839	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
266834001840	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
266834001841	Cytochrome c; Region: Cytochrom_C; cl11414
266834001842	Integrase core domain; Region: rve; pfam00665
266834001843	Integrase core domain; Region: rve; pfam00665
266834001844	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
266834001845	Uncharacterized conserved protein [Function unknown]; Region: COG1633
266834001846	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
266834001847	diiron binding motif [ion binding]; other site
266834001848	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
266834001849	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
266834001850	4Fe-4S binding domain; Region: Fer4_5; pfam12801
266834001851	4Fe-4S binding domain; Region: Fer4_5; pfam12801
266834001852	nitrous-oxide reductase; Validated; Region: PRK02888
266834001853	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
266834001854	Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420
266834001855	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
266834001856	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
266834001857	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
266834001858	Walker A/P-loop; other site
266834001859	ATP binding site [chemical binding]; other site
266834001860	Q-loop/lid; other site
266834001861	ABC transporter signature motif; other site
266834001862	Walker B; other site
266834001863	D-loop; other site
266834001864	H-loop/switch region; other site
266834001865	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
266834001866	Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314
266834001867	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
266834001868	ApbE family; Region: ApbE; pfam02424
266834001869	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
266834001870	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
266834001871	heme-binding site [chemical binding]; other site
266834001872	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
266834001873	FAD binding pocket [chemical binding]; other site
266834001874	FAD binding motif [chemical binding]; other site
266834001875	phosphate binding motif [ion binding]; other site
266834001876	beta-alpha-beta structure motif; other site
266834001877	NAD binding pocket [chemical binding]; other site
266834001878	Heme binding  pocket [chemical binding]; other site
266834001879	Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213
266834001880	Regulator of cell morphogenesis and NO signaling [Cell division and chromosome partitioning]; Region: COG2846
266834001881	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
266834001882	Hemerythrin-like domain; Region: Hr-like; cd12108
266834001883	Fe binding site [ion binding]; other site
266834001884	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
266834001885	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
266834001886	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
266834001887	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
266834001888	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
266834001889	ligand binding site [chemical binding]; other site
266834001890	flexible hinge region; other site
266834001891	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
266834001892	cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847
266834001893	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
266834001894	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
266834001895	metal-binding site [ion binding]
266834001896	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
266834001897	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
266834001898	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
266834001899	FixH; Region: FixH; pfam05751
266834001900	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
266834001901	4Fe-4S binding domain; Region: Fer4_5; pfam12801
266834001902	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
266834001903	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
266834001904	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
266834001905	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
266834001906	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
266834001907	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
266834001908	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
266834001909	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
266834001910	Low-spin heme binding site [chemical binding]; other site
266834001911	Putative water exit pathway; other site
266834001912	Binuclear center (active site) [active]
266834001913	Putative proton exit pathway; other site
266834001914	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
266834001915	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
266834001916	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
266834001917	ligand binding site [chemical binding]; other site
266834001918	flexible hinge region; other site
266834001919	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
266834001920	putative switch regulator; other site
266834001921	non-specific DNA interactions [nucleotide binding]; other site
266834001922	DNA binding site [nucleotide binding]
266834001923	sequence specific DNA binding site [nucleotide binding]; other site
266834001924	putative cAMP binding site [chemical binding]; other site
266834001925	response regulator FixJ; Provisional; Region: fixJ; PRK09390
266834001926	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834001927	active site
266834001928	phosphorylation site [posttranslational modification]
266834001929	intermolecular recognition site; other site
266834001930	dimerization interface [polypeptide binding]; other site
266834001931	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834001932	DNA binding residues [nucleotide binding]
266834001933	dimerization interface [polypeptide binding]; other site
266834001934	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
266834001935	PAS domain S-box; Region: sensory_box; TIGR00229
266834001936	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834001937	putative active site [active]
266834001938	heme pocket [chemical binding]; other site
266834001939	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834001940	dimer interface [polypeptide binding]; other site
266834001941	phosphorylation site [posttranslational modification]
266834001942	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834001943	ATP binding site [chemical binding]; other site
266834001944	Mg2+ binding site [ion binding]; other site
266834001945	G-X-G motif; other site
266834001946	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
266834001947	Ligand Binding Site [chemical binding]; other site
266834001948	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
266834001949	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
266834001950	Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043
266834001951	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
266834001952	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
266834001953	[4Fe-4S] binding site [ion binding]; other site
266834001954	molybdopterin cofactor binding site; other site
266834001955	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
266834001956	molybdopterin cofactor binding site; other site
266834001957	Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062
266834001958	ferredoxin-type protein; Provisional; Region: PRK10194
266834001959	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
266834001960	4Fe-4S binding domain; Region: Fer4; pfam00037
266834001961	Periplasmic nitrate reductase system, NapE component [Energy production and conversion]; Region: NapE; COG4459
266834001962	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
266834001963	pseudoazurin; Region: pseudoazurin; TIGR02375
266834001964	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
266834001965	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
266834001966	ligand binding site [chemical binding]; other site
266834001967	flexible hinge region; other site
266834001968	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
266834001969	putative switch regulator; other site
266834001970	non-specific DNA interactions [nucleotide binding]; other site
266834001971	DNA binding site [nucleotide binding]
266834001972	sequence specific DNA binding site [nucleotide binding]; other site
266834001973	putative cAMP binding site [chemical binding]; other site
266834001974	Uncharacterized conserved protein [Function unknown]; Region: COG1262
266834001975	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
266834001976	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
266834001977	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
266834001978	Multicopper oxidase; Region: Cu-oxidase; pfam00394
266834001979	Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213
266834001980	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834001981	dimerization interface [polypeptide binding]; other site
266834001982	putative DNA binding site [nucleotide binding]; other site
266834001983	putative Zn2+ binding site [ion binding]; other site
266834001984	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
266834001985	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
266834001986	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
266834001987	Uncharacterized conserved protein [Function unknown]; Region: COG4309
266834001988	Pirin-related protein [General function prediction only]; Region: COG1741
266834001989	Pirin; Region: Pirin; pfam02678
266834001990	Uncharacterized conserved protein [Function unknown]; Region: COG1432
266834001991	LabA_like proteins; Region: LabA; cd10911
266834001992	putative metal binding site [ion binding]; other site
266834001993	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
266834001994	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
266834001995	FeS/SAM binding site; other site
266834001996	HemN C-terminal domain; Region: HemN_C; pfam06969
266834001997	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
266834001998	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
266834001999	metal ion-dependent adhesion site (MIDAS); other site
266834002000	MoxR-like ATPases [General function prediction only]; Region: COG0714
266834002001	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
266834002002	Walker A motif; other site
266834002003	ATP binding site [chemical binding]; other site
266834002004	Walker B motif; other site
266834002005	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
266834002006	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
266834002007	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
266834002008	D-pathway; other site
266834002009	K-pathway; other site
266834002010	Binuclear center (active site) [active]
266834002011	Putative proton exit pathway; other site
266834002012	Cytochrome c; Region: Cytochrom_C; pfam00034
266834002013	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
266834002014	Subunit I/III interface [polypeptide binding]; other site
266834002015	Predicted membrane protein [Function unknown]; Region: COG4094
266834002016	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
266834002017	Flavoprotein; Region: Flavoprotein; pfam02441
266834002018	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
266834002019	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
266834002020	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
266834002021	Peptidase family U32; Region: Peptidase_U32; pfam01136
266834002022	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
266834002023	putative protease; Provisional; Region: PRK15447
266834002024	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
266834002025	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
266834002026	NAD binding site [chemical binding]; other site
266834002027	substrate binding site [chemical binding]; other site
266834002028	catalytic Zn binding site [ion binding]; other site
266834002029	tetramer interface [polypeptide binding]; other site
266834002030	structural Zn binding site [ion binding]; other site
266834002031	Predicted membrane protein [Function unknown]; Region: COG3619
266834002032	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834002033	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834002034	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834002035	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
266834002036	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
266834002037	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
266834002038	Walker A motif; other site
266834002039	hexamer interface [polypeptide binding]; other site
266834002040	ATP binding site [chemical binding]; other site
266834002041	Walker B motif; other site
266834002042	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
266834002043	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
266834002044	VirB7 interaction site; other site
266834002045	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
266834002046	Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704
266834002047	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
266834002048	Type IV secretion system proteins; Region: T4SS; pfam07996
266834002049	Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
266834002050	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
266834002051	Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702
266834002052	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
266834002053	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
266834002054	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
266834002055	N-terminal domain interface [polypeptide binding]; other site
266834002056	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
266834002057	RibD C-terminal domain; Region: RibD_C; cl17279
266834002058	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
266834002059	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
266834002060	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
266834002061	TAP-like protein; Region: Abhydrolase_4; pfam08386
266834002062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834002063	metabolite-proton symporter; Region: 2A0106; TIGR00883
266834002064	putative substrate translocation pore; other site
266834002065	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
266834002066	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
266834002067	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
266834002068	active site
266834002069	Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140
266834002070	Cupin domain; Region: Cupin_2; pfam07883
266834002071	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
266834002072	Uncharacterized conserved protein [Function unknown]; Region: COG5441
266834002073	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
266834002074	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834002075	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834002076	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
266834002077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834002078	conserved gate region; other site
266834002079	dimer interface [polypeptide binding]; other site
266834002080	putative PBP binding loops; other site
266834002081	ABC-ATPase subunit interface; other site
266834002082	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834002083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834002084	dimer interface [polypeptide binding]; other site
266834002085	conserved gate region; other site
266834002086	putative PBP binding loops; other site
266834002087	ABC-ATPase subunit interface; other site
266834002088	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
266834002089	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834002090	Walker A/P-loop; other site
266834002091	ATP binding site [chemical binding]; other site
266834002092	Q-loop/lid; other site
266834002093	ABC transporter signature motif; other site
266834002094	Walker B; other site
266834002095	D-loop; other site
266834002096	H-loop/switch region; other site
266834002097	TOBE domain; Region: TOBE_2; pfam08402
266834002098	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
266834002099	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834002100	Walker A/P-loop; other site
266834002101	ATP binding site [chemical binding]; other site
266834002102	Q-loop/lid; other site
266834002103	ABC transporter signature motif; other site
266834002104	Walker B; other site
266834002105	D-loop; other site
266834002106	H-loop/switch region; other site
266834002107	TOBE domain; Region: TOBE_2; pfam08402
266834002108	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
266834002109	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
266834002110	ligand binding site [chemical binding]; other site
266834002111	NAD binding site [chemical binding]; other site
266834002112	dimerization interface [polypeptide binding]; other site
266834002113	catalytic site [active]
266834002114	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834002115	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834002116	DNA-binding site [nucleotide binding]; DNA binding site
266834002117	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
266834002118	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
266834002119	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
266834002120	active site pocket [active]
266834002121	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
266834002122	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
266834002123	DNA interaction; other site
266834002124	Metal-binding active site; metal-binding site
266834002125	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
266834002126	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
266834002127	Metal-binding active site; metal-binding site
266834002128	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
266834002129	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
266834002130	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
266834002131	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834002132	MULE transposase domain; Region: MULE; pfam10551
266834002133	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
266834002134	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834002135	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
266834002136	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834002137	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834002138	dimer interface [polypeptide binding]; other site
266834002139	conserved gate region; other site
266834002140	putative PBP binding loops; other site
266834002141	ABC-ATPase subunit interface; other site
266834002142	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
266834002143	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834002144	dimer interface [polypeptide binding]; other site
266834002145	putative PBP binding loops; other site
266834002146	ABC-ATPase subunit interface; other site
266834002147	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834002148	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
266834002149	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
266834002150	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
266834002151	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834002152	H-loop/switch region; other site
266834002153	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834002154	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834002155	NAD(P) binding site [chemical binding]; other site
266834002156	active site
266834002157	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
266834002158	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834002159	Walker A/P-loop; other site
266834002160	ATP binding site [chemical binding]; other site
266834002161	Q-loop/lid; other site
266834002162	ABC transporter signature motif; other site
266834002163	Walker B; other site
266834002164	D-loop; other site
266834002165	H-loop/switch region; other site
266834002166	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
266834002167	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
266834002168	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834002169	Walker A/P-loop; other site
266834002170	ATP binding site [chemical binding]; other site
266834002171	Q-loop/lid; other site
266834002172	ABC transporter signature motif; other site
266834002173	Walker B; other site
266834002174	D-loop; other site
266834002175	H-loop/switch region; other site
266834002176	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834002177	dipeptide transporter; Provisional; Region: PRK10913
266834002178	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834002179	dimer interface [polypeptide binding]; other site
266834002180	conserved gate region; other site
266834002181	putative PBP binding loops; other site
266834002182	ABC-ATPase subunit interface; other site
266834002183	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834002184	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834002185	dimer interface [polypeptide binding]; other site
266834002186	conserved gate region; other site
266834002187	putative PBP binding loops; other site
266834002188	ABC-ATPase subunit interface; other site
266834002189	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834002190	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
266834002191	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
266834002192	Amidase; Region: Amidase; cl11426
266834002193	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834002194	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
266834002195	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
266834002196	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
266834002197	catalytic loop [active]
266834002198	iron binding site [ion binding]; other site
266834002199	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834002200	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
266834002201	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834002202	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834002203	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
266834002204	dimerization interface [polypeptide binding]; other site
266834002205	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
266834002206	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
266834002207	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
266834002208	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
266834002209	Ligand binding site [chemical binding]; other site
266834002210	Electron transfer flavoprotein domain; Region: ETF; pfam01012
266834002211	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
266834002212	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
266834002213	Metal-binding active site; metal-binding site
266834002214	Protein of unknown function (DUF993); Region: DUF993; pfam06187
266834002215	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
266834002216	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834002217	NAD(P) binding site [chemical binding]; other site
266834002218	active site
266834002219	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
266834002220	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
266834002221	active site
266834002222	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834002223	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834002224	active site
266834002225	catalytic tetrad [active]
266834002226	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
266834002227	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
266834002228	MOFRL family; Region: MOFRL; pfam05161
266834002229	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
266834002230	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
266834002231	substrate binding site [chemical binding]; other site
266834002232	oxyanion hole (OAH) forming residues; other site
266834002233	trimer interface [polypeptide binding]; other site
266834002234	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
266834002235	Coenzyme A transferase; Region: CoA_trans; smart00882
266834002236	Coenzyme A transferase; Region: CoA_trans; cl17247
266834002237	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834002238	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834002239	active site
266834002240	catalytic tetrad [active]
266834002241	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
266834002242	choline dehydrogenase; Validated; Region: PRK02106
266834002243	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
266834002244	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
266834002245	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
266834002246	NAD(P) binding site [chemical binding]; other site
266834002247	catalytic residues [active]
266834002248	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
266834002249	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
266834002250	NAD(P) binding site [chemical binding]; other site
266834002251	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834002252	TM-ABC transporter signature motif; other site
266834002253	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834002254	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834002255	Walker A/P-loop; other site
266834002256	ATP binding site [chemical binding]; other site
266834002257	Q-loop/lid; other site
266834002258	ABC transporter signature motif; other site
266834002259	Walker B; other site
266834002260	D-loop; other site
266834002261	H-loop/switch region; other site
266834002262	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834002263	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834002264	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834002265	TM-ABC transporter signature motif; other site
266834002266	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834002267	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
266834002268	ligand binding site [chemical binding]; other site
266834002269	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834002270	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834002271	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
266834002272	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
266834002273	putative NAD(P) binding site [chemical binding]; other site
266834002274	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834002275	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
266834002276	active site
266834002277	metal binding site [ion binding]; metal-binding site
266834002278	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
266834002279	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834002280	Walker A/P-loop; other site
266834002281	ATP binding site [chemical binding]; other site
266834002282	Q-loop/lid; other site
266834002283	ABC transporter signature motif; other site
266834002284	Walker B; other site
266834002285	D-loop; other site
266834002286	H-loop/switch region; other site
266834002287	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
266834002288	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834002289	Walker A/P-loop; other site
266834002290	ATP binding site [chemical binding]; other site
266834002291	Q-loop/lid; other site
266834002292	ABC transporter signature motif; other site
266834002293	Walker B; other site
266834002294	D-loop; other site
266834002295	H-loop/switch region; other site
266834002296	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834002297	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
266834002298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834002299	dimer interface [polypeptide binding]; other site
266834002300	conserved gate region; other site
266834002301	putative PBP binding loops; other site
266834002302	ABC-ATPase subunit interface; other site
266834002303	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834002304	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834002305	dimer interface [polypeptide binding]; other site
266834002306	conserved gate region; other site
266834002307	putative PBP binding loops; other site
266834002308	ABC-ATPase subunit interface; other site
266834002309	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834002310	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491
266834002311	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
266834002312	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
266834002313	putative active site [active]
266834002314	catalytic residue [active]
266834002315	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834002316	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834002317	DNA-binding site [nucleotide binding]; DNA binding site
266834002318	FCD domain; Region: FCD; pfam07729
266834002319	Ferritin-like domain; Region: Ferritin_2; pfam13668
266834002320	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834002321	putative substrate translocation pore; other site
266834002322	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834002323	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
266834002324	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
266834002325	dimer interface [polypeptide binding]; other site
266834002326	active site
266834002327	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
266834002328	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
266834002329	NAD binding site [chemical binding]; other site
266834002330	homodimer interface [polypeptide binding]; other site
266834002331	homotetramer interface [polypeptide binding]; other site
266834002332	active site
266834002333	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
266834002334	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834002335	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834002336	Uncharacterized conserved protein [Function unknown]; Region: COG5654
266834002337	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
266834002338	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
266834002339	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
266834002340	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
266834002341	active site pocket [active]
266834002342	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
266834002343	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
266834002344	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834002345	dimer interface [polypeptide binding]; other site
266834002346	conserved gate region; other site
266834002347	putative PBP binding loops; other site
266834002348	ABC-ATPase subunit interface; other site
266834002349	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
266834002350	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
266834002351	Walker A/P-loop; other site
266834002352	ATP binding site [chemical binding]; other site
266834002353	Q-loop/lid; other site
266834002354	ABC transporter signature motif; other site
266834002355	Walker B; other site
266834002356	D-loop; other site
266834002357	H-loop/switch region; other site
266834002358	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
266834002359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834002360	dimer interface [polypeptide binding]; other site
266834002361	conserved gate region; other site
266834002362	ABC-ATPase subunit interface; other site
266834002363	Isochorismatase family; Region: Isochorismatase; pfam00857
266834002364	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
266834002365	catalytic triad [active]
266834002366	conserved cis-peptide bond; other site
266834002367	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
266834002368	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
266834002369	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
266834002370	active site
266834002371	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
266834002372	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
266834002373	conserved cys residue [active]
266834002374	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834002375	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834002376	Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253
266834002377	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
266834002378	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834002379	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834002380	dimerization interface [polypeptide binding]; other site
266834002381	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834002382	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834002383	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
266834002384	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
266834002385	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
266834002386	Uncharacterized conserved protein [Function unknown]; Region: COG4925
266834002387	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
266834002388	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834002389	putative substrate translocation pore; other site
266834002390	Cytochrome c2 [Energy production and conversion]; Region: COG3474
266834002391	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834002392	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
266834002393	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
266834002394	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834002395	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834002396	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
266834002397	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834002398	catalytic loop [active]
266834002399	iron binding site [ion binding]; other site
266834002400	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
266834002401	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834002402	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834002403	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
266834002404	putative effector binding pocket; other site
266834002405	putative dimerization interface [polypeptide binding]; other site
266834002406	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
266834002407	homodimer interface [polypeptide binding]; other site
266834002408	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834002409	catalytic residue [active]
266834002410	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834002411	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
266834002412	putative C-terminal domain interface [polypeptide binding]; other site
266834002413	putative GSH binding site (G-site) [chemical binding]; other site
266834002414	putative dimer interface [polypeptide binding]; other site
266834002415	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
266834002416	putative N-terminal domain interface [polypeptide binding]; other site
266834002417	putative dimer interface [polypeptide binding]; other site
266834002418	putative substrate binding pocket (H-site) [chemical binding]; other site
266834002419	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
266834002420	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
266834002421	[2Fe-2S] cluster binding site [ion binding]; other site
266834002422	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
266834002423	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
266834002424	FMN-binding pocket [chemical binding]; other site
266834002425	flavin binding motif; other site
266834002426	phosphate binding motif [ion binding]; other site
266834002427	beta-alpha-beta structure motif; other site
266834002428	NAD binding pocket [chemical binding]; other site
266834002429	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834002430	catalytic loop [active]
266834002431	iron binding site [ion binding]; other site
266834002432	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
266834002433	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
266834002434	hydrophobic ligand binding site; other site
266834002435	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
266834002436	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
266834002437	hydrophobic ligand binding site; other site
266834002438	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834002439	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834002440	DNA-binding site [nucleotide binding]; DNA binding site
266834002441	FCD domain; Region: FCD; pfam07729
266834002442	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
266834002443	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
266834002444	putative ligand binding site [chemical binding]; other site
266834002445	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
266834002446	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834002447	Walker A/P-loop; other site
266834002448	ATP binding site [chemical binding]; other site
266834002449	Q-loop/lid; other site
266834002450	ABC transporter signature motif; other site
266834002451	Walker B; other site
266834002452	D-loop; other site
266834002453	H-loop/switch region; other site
266834002454	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834002455	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834002456	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
266834002457	TM-ABC transporter signature motif; other site
266834002458	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834002459	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
266834002460	TM-ABC transporter signature motif; other site
266834002461	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
266834002462	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
266834002463	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
266834002464	4Fe-4S binding domain; Region: Fer4; pfam00037
266834002465	FOG: CBS domain [General function prediction only]; Region: COG0517
266834002466	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
266834002467	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
266834002468	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834002469	catalytic loop [active]
266834002470	iron binding site [ion binding]; other site
266834002471	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
266834002472	4Fe-4S binding domain; Region: Fer4; pfam00037
266834002473	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
266834002474	[4Fe-4S] binding site [ion binding]; other site
266834002475	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
266834002476	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
266834002477	SLBB domain; Region: SLBB; pfam10531
266834002478	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
266834002479	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
266834002480	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
266834002481	putative dimer interface [polypeptide binding]; other site
266834002482	[2Fe-2S] cluster binding site [ion binding]; other site
266834002483	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
266834002484	NADH dehydrogenase subunit D; Validated; Region: PRK06075
266834002485	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
266834002486	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
266834002487	NADH dehydrogenase subunit B; Validated; Region: PRK06411
266834002488	NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838
266834002489	proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770
266834002490	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
266834002491	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
266834002492	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
266834002493	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668
266834002494	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
266834002495	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
266834002496	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
266834002497	NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713
266834002498	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
266834002499	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
266834002500	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
266834002501	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834002502	S-adenosylmethionine binding site [chemical binding]; other site
266834002503	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834002504	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
266834002505	putative active site [active]
266834002506	heme pocket [chemical binding]; other site
266834002507	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
266834002508	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834002509	putative active site [active]
266834002510	heme pocket [chemical binding]; other site
266834002511	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834002512	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
266834002513	putative active site [active]
266834002514	heme pocket [chemical binding]; other site
266834002515	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834002516	putative active site [active]
266834002517	heme pocket [chemical binding]; other site
266834002518	PAS fold; Region: PAS_4; pfam08448
266834002519	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834002520	putative active site [active]
266834002521	heme pocket [chemical binding]; other site
266834002522	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
266834002523	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834002524	metal binding site [ion binding]; metal-binding site
266834002525	active site
266834002526	I-site; other site
266834002527	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834002528	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
266834002529	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834002530	active site
266834002531	phosphorylation site [posttranslational modification]
266834002532	intermolecular recognition site; other site
266834002533	dimerization interface [polypeptide binding]; other site
266834002534	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834002535	DNA binding residues [nucleotide binding]
266834002536	dimerization interface [polypeptide binding]; other site
266834002537	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
266834002538	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834002539	TPR repeat; Region: TPR_11; pfam13414
266834002540	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
266834002541	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
266834002542	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
266834002543	dimer interface [polypeptide binding]; other site
266834002544	putative CheW interface [polypeptide binding]; other site
266834002545	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
266834002546	putative binding surface; other site
266834002547	active site
266834002548	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
266834002549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834002550	ATP binding site [chemical binding]; other site
266834002551	Mg2+ binding site [ion binding]; other site
266834002552	G-X-G motif; other site
266834002553	CheW-like domain; Region: CheW; pfam01584
266834002554	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
266834002555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834002556	active site
266834002557	phosphorylation site [posttranslational modification]
266834002558	intermolecular recognition site; other site
266834002559	dimerization interface [polypeptide binding]; other site
266834002560	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
266834002561	CheB methylesterase; Region: CheB_methylest; pfam01339
266834002562	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
266834002563	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
266834002564	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
266834002565	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
266834002566	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
266834002567	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
266834002568	ATP binding site [chemical binding]; other site
266834002569	Walker A motif; other site
266834002570	hexamer interface [polypeptide binding]; other site
266834002571	Walker B motif; other site
266834002572	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
266834002573	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
266834002574	TadE-like protein; Region: TadE; pfam07811
266834002575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
266834002576	active site
266834002577	dimerization interface [polypeptide binding]; other site
266834002578	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
266834002579	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
266834002580	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
266834002581	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
266834002582	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
266834002583	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
266834002584	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
266834002585	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
266834002586	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
266834002587	Mechanosensitive ion channel; Region: MS_channel; pfam00924
266834002588	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834002589	cyclase homology domain; Region: CHD; cd07302
266834002590	nucleotidyl binding site; other site
266834002591	metal binding site [ion binding]; metal-binding site
266834002592	dimer interface [polypeptide binding]; other site
266834002593	Predicted integral membrane protein [Function unknown]; Region: COG5616
266834002594	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834002595	TPR motif; other site
266834002596	TPR repeat; Region: TPR_11; pfam13414
266834002597	binding surface
266834002598	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834002599	binding surface
266834002600	TPR motif; other site
266834002601	Tetratricopeptide repeat; Region: TPR_16; pfam13432
266834002602	Transposase; Region: HTH_Tnp_1; cl17663
266834002603	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
266834002604	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
266834002605	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
266834002606	active site
266834002607	catalytic residues [active]
266834002608	Predicted ester cyclase [General function prediction only]; Region: COG5485
266834002609	Sterile alpha motif; Region: SAM; smart00454
266834002610	SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487
266834002611	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834002612	cyclase homology domain; Region: CHD; cd07302
266834002613	nucleotidyl binding site; other site
266834002614	metal binding site [ion binding]; metal-binding site
266834002615	dimer interface [polypeptide binding]; other site
266834002616	Predicted ATPase [General function prediction only]; Region: COG3899
266834002617	AAA ATPase domain; Region: AAA_16; pfam13191
266834002618	Predicted ATPase [General function prediction only]; Region: COG3903
266834002619	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834002620	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
266834002621	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
266834002622	[2Fe-2S] cluster binding site [ion binding]; other site
266834002623	FAD dependent oxidoreductase; Region: DAO; pfam01266
266834002624	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
266834002625	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
266834002626	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
266834002627	putative cation:proton antiport protein; Provisional; Region: PRK10669
266834002628	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
266834002629	TrkA-N domain; Region: TrkA_N; pfam02254
266834002630	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834002631	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834002632	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834002633	putative effector binding pocket; other site
266834002634	dimerization interface [polypeptide binding]; other site
266834002635	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
266834002636	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
266834002637	FMN binding site [chemical binding]; other site
266834002638	active site
266834002639	substrate binding site [chemical binding]; other site
266834002640	catalytic residue [active]
266834002641	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
266834002642	NAD(P) binding site [chemical binding]; other site
266834002643	NADH(P)-binding; Region: NAD_binding_10; pfam13460
266834002644	putative active site [active]
266834002645	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
266834002646	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
266834002647	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
266834002648	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834002649	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
266834002650	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
266834002651	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834002652	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
266834002653	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
266834002654	HTH-like domain; Region: HTH_21; pfam13276
266834002655	Integrase core domain; Region: rve; pfam00665
266834002656	Integrase core domain; Region: rve_3; pfam13683
266834002657	Transposase; Region: HTH_Tnp_1; cl17663
266834002658	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834002659	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
266834002660	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
266834002661	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
266834002662	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
266834002663	active site
266834002664	DNA binding site [nucleotide binding]
266834002665	Int/Topo IB signature motif; other site
266834002666	INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187
266834002667	Int/Topo IB signature motif; other site
266834002668	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
266834002669	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
266834002670	Int/Topo IB signature motif; other site
266834002671	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834002672	Transposase; Region: HTH_Tnp_1; pfam01527
266834002673	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834002674	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834002675	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
266834002676	substrate binding pocket [chemical binding]; other site
266834002677	dimerization interface [polypeptide binding]; other site
266834002678	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803
266834002679	short chain dehydrogenase; Provisional; Region: PRK06523
266834002680	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834002681	NAD(P) binding site [chemical binding]; other site
266834002682	active site
266834002683	SnoaL-like domain; Region: SnoaL_2; pfam12680
266834002684	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834002685	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834002686	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
266834002687	putative effector binding pocket; other site
266834002688	putative dimerization interface [polypeptide binding]; other site
266834002689	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
266834002690	Transposase domain (DUF772); Region: DUF772; pfam05598
266834002691	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
266834002692	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
266834002693	Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154
266834002694	putative homodimer interface [polypeptide binding]; other site
266834002695	putative homotetramer interface [polypeptide binding]; other site
266834002696	putative metal binding site [ion binding]; other site
266834002697	putative homodimer-homodimer interface [polypeptide binding]; other site
266834002698	putative allosteric switch controlling residues; other site
266834002699	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834002700	putative substrate translocation pore; other site
266834002701	Predicted membrane protein [Function unknown]; Region: COG1238
266834002702	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
266834002703	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
266834002704	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834002705	Walker A/P-loop; other site
266834002706	ATP binding site [chemical binding]; other site
266834002707	Q-loop/lid; other site
266834002708	ABC transporter signature motif; other site
266834002709	Walker B; other site
266834002710	D-loop; other site
266834002711	H-loop/switch region; other site
266834002712	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
266834002713	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
266834002714	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834002715	Walker A/P-loop; other site
266834002716	ATP binding site [chemical binding]; other site
266834002717	Q-loop/lid; other site
266834002718	ABC transporter signature motif; other site
266834002719	Walker B; other site
266834002720	D-loop; other site
266834002721	H-loop/switch region; other site
266834002722	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834002723	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
266834002724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834002725	dimer interface [polypeptide binding]; other site
266834002726	conserved gate region; other site
266834002727	putative PBP binding loops; other site
266834002728	ABC-ATPase subunit interface; other site
266834002729	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834002730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834002731	dimer interface [polypeptide binding]; other site
266834002732	conserved gate region; other site
266834002733	putative PBP binding loops; other site
266834002734	ABC-ATPase subunit interface; other site
266834002735	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834002736	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
266834002737	substrate binding site [chemical binding]; other site
266834002738	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
266834002739	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
266834002740	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834002741	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834002742	DNA-binding site [nucleotide binding]; DNA binding site
266834002743	FCD domain; Region: FCD; pfam07729
266834002744	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
266834002745	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834002746	Coenzyme A binding pocket [chemical binding]; other site
266834002747	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
266834002748	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
266834002749	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
266834002750	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834002751	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834002752	Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350
266834002753	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
266834002754	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
266834002755	arginine deiminase; Provisional; Region: PRK01388
266834002756	Predicted membrane protein [Function unknown]; Region: COG4803
266834002757	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
266834002758	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
266834002759	Domain of unknown function DUF20; Region: UPF0118; pfam01594
266834002760	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
266834002761	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
266834002762	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
266834002763	active site
266834002764	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
266834002765	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834002766	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
266834002767	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
266834002768	TPR repeat; Region: TPR_11; pfam13414
266834002769	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834002770	TPR motif; other site
266834002771	binding surface
266834002772	Tetratricopeptide repeat; Region: TPR_16; pfam13432
266834002773	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
266834002774	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
266834002775	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834002776	motif II; other site
266834002777	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
266834002778	Sulfatase; Region: Sulfatase; pfam00884
266834002779	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834002780	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834002781	dimer interface [polypeptide binding]; other site
266834002782	phosphorylation site [posttranslational modification]
266834002783	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834002784	ATP binding site [chemical binding]; other site
266834002785	Mg2+ binding site [ion binding]; other site
266834002786	G-X-G motif; other site
266834002787	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
266834002788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834002789	active site
266834002790	phosphorylation site [posttranslational modification]
266834002791	intermolecular recognition site; other site
266834002792	dimerization interface [polypeptide binding]; other site
266834002793	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834002794	DNA binding residues [nucleotide binding]
266834002795	dimerization interface [polypeptide binding]; other site
266834002796	Response regulator receiver domain; Region: Response_reg; pfam00072
266834002797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834002798	active site
266834002799	phosphorylation site [posttranslational modification]
266834002800	intermolecular recognition site; other site
266834002801	dimerization interface [polypeptide binding]; other site
266834002802	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
266834002803	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
266834002804	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
266834002805	HWE histidine kinase; Region: HWE_HK; pfam07536
266834002806	Transposase; Region: HTH_Tnp_1; cl17663
266834002807	Predicted membrane protein [Function unknown]; Region: COG4292
266834002808	Predicted transcriptional regulator [Transcription]; Region: COG4957
266834002809	Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999
266834002810	active site
266834002811	Mn binding site [ion binding]; other site
266834002812	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
266834002813	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
266834002814	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
266834002815	active site
266834002816	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
266834002817	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
266834002818	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
266834002819	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
266834002820	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
266834002821	active site
266834002822	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
266834002823	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834002824	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834002825	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834002826	putative effector binding pocket; other site
266834002827	dimerization interface [polypeptide binding]; other site
266834002828	Isochorismatase family; Region: Isochorismatase; pfam00857
266834002829	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
266834002830	catalytic triad [active]
266834002831	conserved cis-peptide bond; other site
266834002832	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
266834002833	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
266834002834	conserved cys residue [active]
266834002835	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834002836	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
266834002837	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834002838	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
266834002839	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
266834002840	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
266834002841	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
266834002842	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
266834002843	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
266834002844	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
266834002845	NAD(P) binding site [chemical binding]; other site
266834002846	catalytic residues [active]
266834002847	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
266834002848	iron-sulfur cluster [ion binding]; other site
266834002849	[2Fe-2S] cluster binding site [ion binding]; other site
266834002850	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
266834002851	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
266834002852	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
266834002853	FAD binding pocket [chemical binding]; other site
266834002854	FAD binding motif [chemical binding]; other site
266834002855	phosphate binding motif [ion binding]; other site
266834002856	beta-alpha-beta structure motif; other site
266834002857	NAD binding pocket [chemical binding]; other site
266834002858	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834002859	catalytic loop [active]
266834002860	iron binding site [ion binding]; other site
266834002861	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834002862	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834002863	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
266834002864	dimerization interface [polypeptide binding]; other site
266834002865	Predicted membrane protein [Function unknown]; Region: COG2855
266834002866	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
266834002867	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
266834002868	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
266834002869	FAD binding pocket [chemical binding]; other site
266834002870	FAD binding motif [chemical binding]; other site
266834002871	phosphate binding motif [ion binding]; other site
266834002872	NAD binding pocket [chemical binding]; other site
266834002873	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
266834002874	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
266834002875	Walker A/P-loop; other site
266834002876	ATP binding site [chemical binding]; other site
266834002877	Q-loop/lid; other site
266834002878	ABC transporter signature motif; other site
266834002879	Walker B; other site
266834002880	D-loop; other site
266834002881	H-loop/switch region; other site
266834002882	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
266834002883	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
266834002884	ABC-ATPase subunit  interface; other site
266834002885	dimer interface [polypeptide binding]; other site
266834002886	putative PBP binding regions; other site
266834002887	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
266834002888	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
266834002889	ABC-ATPase subunit  interface; other site
266834002890	dimer interface [polypeptide binding]; other site
266834002891	putative PBP binding regions; other site
266834002892	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
266834002893	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
266834002894	intersubunit interface [polypeptide binding]; other site
266834002895	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
266834002896	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
266834002897	N-terminal plug; other site
266834002898	ligand-binding site [chemical binding]; other site
266834002899	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
266834002900	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834002901	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834002902	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834002903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834002904	dimer interface [polypeptide binding]; other site
266834002905	conserved gate region; other site
266834002906	putative PBP binding loops; other site
266834002907	ABC-ATPase subunit interface; other site
266834002908	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834002909	dimer interface [polypeptide binding]; other site
266834002910	conserved gate region; other site
266834002911	putative PBP binding loops; other site
266834002912	ABC-ATPase subunit interface; other site
266834002913	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
266834002914	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
266834002915	Walker A/P-loop; other site
266834002916	ATP binding site [chemical binding]; other site
266834002917	Q-loop/lid; other site
266834002918	ABC transporter signature motif; other site
266834002919	Walker B; other site
266834002920	D-loop; other site
266834002921	H-loop/switch region; other site
266834002922	TOBE domain; Region: TOBE_2; pfam08402
266834002923	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
266834002924	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
266834002925	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834002926	classical (c) SDRs; Region: SDR_c; cd05233
266834002927	NAD(P) binding site [chemical binding]; other site
266834002928	active site
266834002929	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834002930	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834002931	DNA-binding site [nucleotide binding]; DNA binding site
266834002932	FCD domain; Region: FCD; pfam07729
266834002933	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
266834002934	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
266834002935	active site
266834002936	ATP binding site [chemical binding]; other site
266834002937	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
266834002938	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834002939	inhibitor-cofactor binding pocket; inhibition site
266834002940	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834002941	catalytic residue [active]
266834002942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753
266834002943	Predicted membrane protein [Function unknown]; Region: COG2261
266834002944	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
266834002945	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
266834002946	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
266834002947	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834002948	Predicted membrane protein [Function unknown]; Region: COG4125
266834002949	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
266834002950	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
266834002951	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834002952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834002953	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
266834002954	dimerization interface [polypeptide binding]; other site
266834002955	Transposase domain (DUF772); Region: DUF772; pfam05598
266834002956	Sterile alpha motif; Region: SAM; smart00454
266834002957	SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487
266834002958	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834002959	cyclase homology domain; Region: CHD; cd07302
266834002960	nucleotidyl binding site; other site
266834002961	metal binding site [ion binding]; metal-binding site
266834002962	dimer interface [polypeptide binding]; other site
266834002963	Predicted ATPase [General function prediction only]; Region: COG3899
266834002964	AAA ATPase domain; Region: AAA_16; pfam13191
266834002965	Predicted ATPase [General function prediction only]; Region: COG3903
266834002966	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
266834002967	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
266834002968	DDE superfamily endonuclease; Region: DDE_3; pfam13358
266834002969	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
266834002970	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
266834002971	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
266834002972	putative active site [active]
266834002973	putative NTP binding site [chemical binding]; other site
266834002974	putative nucleic acid binding site [nucleotide binding]; other site
266834002975	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
266834002976	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
266834002977	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834002978	Homeodomain-like domain; Region: HTH_32; pfam13565
266834002979	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
266834002980	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
266834002981	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
266834002982	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
266834002983	Transmembrane secretion effector; Region: MFS_3; pfam05977
266834002984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834002985	putative substrate translocation pore; other site
266834002986	Predicted membrane protein [Function unknown]; Region: COG2259
266834002987	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
266834002988	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
266834002989	active site
266834002990	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4317
266834002991	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
266834002992	Isochorismatase family; Region: Isochorismatase; pfam00857
266834002993	catalytic triad [active]
266834002994	dimer interface [polypeptide binding]; other site
266834002995	conserved cis-peptide bond; other site
266834002996	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834002997	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834002998	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834002999	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834003000	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834003001	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834003002	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834003003	Helix-turn-helix domain; Region: HTH_18; pfam12833
266834003004	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834003005	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12680
266834003006	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003007	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834003008	putative effector binding pocket; other site
266834003009	dimerization interface [polypeptide binding]; other site
266834003010	Predicted esterase [General function prediction only]; Region: COG0400
266834003011	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
266834003012	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
266834003013	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
266834003014	acetylornithine deacetylase; Provisional; Region: PRK07522
266834003015	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
266834003016	metal binding site [ion binding]; metal-binding site
266834003017	putative dimer interface [polypeptide binding]; other site
266834003018	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
266834003019	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
266834003020	putative ligand binding site [chemical binding]; other site
266834003021	NAD binding site [chemical binding]; other site
266834003022	dimerization interface [polypeptide binding]; other site
266834003023	catalytic site [active]
266834003024	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
266834003025	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
266834003026	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
266834003027	NAD(P) binding site [chemical binding]; other site
266834003028	catalytic residues [active]
266834003029	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
266834003030	tartrate dehydrogenase; Region: TTC; TIGR02089
266834003031	succinic semialdehyde dehydrogenase; Region: PLN02278
266834003032	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
266834003033	tetramerization interface [polypeptide binding]; other site
266834003034	NAD(P) binding site [chemical binding]; other site
266834003035	catalytic residues [active]
266834003036	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
266834003037	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834003038	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
266834003039	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
266834003040	putative acetyltransferase; Provisional; Region: PRK03624
266834003041	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834003042	Coenzyme A binding pocket [chemical binding]; other site
266834003043	hypothetical protein; Provisional; Region: PRK05965
266834003044	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834003045	inhibitor-cofactor binding pocket; inhibition site
266834003046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834003047	catalytic residue [active]
266834003048	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
266834003049	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
266834003050	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834003051	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
266834003052	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834003053	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834003054	dimer interface [polypeptide binding]; other site
266834003055	conserved gate region; other site
266834003056	putative PBP binding loops; other site
266834003057	ABC-ATPase subunit interface; other site
266834003058	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
266834003059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834003060	dimer interface [polypeptide binding]; other site
266834003061	conserved gate region; other site
266834003062	ABC-ATPase subunit interface; other site
266834003063	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
266834003064	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834003065	Walker A/P-loop; other site
266834003066	ATP binding site [chemical binding]; other site
266834003067	Q-loop/lid; other site
266834003068	ABC transporter signature motif; other site
266834003069	Walker B; other site
266834003070	D-loop; other site
266834003071	H-loop/switch region; other site
266834003072	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834003073	Walker A/P-loop; other site
266834003074	ATP binding site [chemical binding]; other site
266834003075	Q-loop/lid; other site
266834003076	ABC transporter signature motif; other site
266834003077	Walker B; other site
266834003078	D-loop; other site
266834003079	H-loop/switch region; other site
266834003080	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834003081	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834003082	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834003083	putative DNA binding site [nucleotide binding]; other site
266834003084	putative Zn2+ binding site [ion binding]; other site
266834003085	AsnC family; Region: AsnC_trans_reg; pfam01037
266834003086	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834003087	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
266834003088	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
266834003089	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
266834003090	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
266834003091	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
266834003092	tetramer interface [polypeptide binding]; other site
266834003093	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834003094	catalytic residue [active]
266834003095	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
266834003096	DNA binding site [nucleotide binding]
266834003097	active site
266834003098	Int/Topo IB signature motif; other site
266834003099	catalytic residues [active]
266834003100	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
266834003101	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
266834003102	putative active site [active]
266834003103	putative NTP binding site [chemical binding]; other site
266834003104	putative nucleic acid binding site [nucleotide binding]; other site
266834003105	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
266834003106	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
266834003107	Sulfocyanin (SoxE); Region: SoxE; cl17563
266834003108	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834003109	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834003110	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
266834003111	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
266834003112	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834003113	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834003114	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834003115	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
266834003116	PHB binding site; other site
266834003117	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834003118	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
266834003119	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834003120	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003121	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
266834003122	dimerization interface [polypeptide binding]; other site
266834003123	methionine sulfoxide reductase B; Provisional; Region: PRK00222
266834003124	SelR domain; Region: SelR; pfam01641
266834003125	methionine sulfoxide reductase A; Provisional; Region: PRK14054
266834003126	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
266834003127	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
266834003128	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
266834003129	active site
266834003130	catalytic residues [active]
266834003131	Transglycosylase; Region: Transgly; pfam00912
266834003132	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
266834003133	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
266834003134	BA14K-like protein; Region: BA14K; pfam07886
266834003135	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
266834003136	Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004
266834003137	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
266834003138	transmembrane helices; other site
266834003139	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
266834003140	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
266834003141	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
266834003142	Predicted nucleotide kinase (related to CMP and AMP kinases) [Nucleotide transport and metabolism]; Region: COG1936
266834003143	AAA domain; Region: AAA_17; pfam13207
266834003144	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834003145	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003146	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834003147	dimerization interface [polypeptide binding]; other site
266834003148	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
266834003149	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
266834003150	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
266834003151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834003152	putative substrate translocation pore; other site
266834003153	hypothetical protein; Provisional; Region: PRK06834
266834003154	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
266834003155	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003156	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834003157	dimerization interface [polypeptide binding]; other site
266834003158	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
266834003159	EamA-like transporter family; Region: EamA; pfam00892
266834003160	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
266834003161	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
266834003162	ligand binding site [chemical binding]; other site
266834003163	flexible hinge region; other site
266834003164	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
266834003165	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
266834003166	Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666
266834003167	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
266834003168	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
266834003169	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
266834003170	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834003171	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003172	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
266834003173	substrate binding pocket [chemical binding]; other site
266834003174	dimerization interface [polypeptide binding]; other site
266834003175	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834003176	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003177	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
266834003178	substrate binding pocket [chemical binding]; other site
266834003179	dimerization interface [polypeptide binding]; other site
266834003180	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
266834003181	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834003182	NAD(P) binding site [chemical binding]; other site
266834003183	active site
266834003184	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
266834003185	Predicted transcriptional regulators [Transcription]; Region: COG1733
266834003186	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
266834003187	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
266834003188	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
266834003189	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
266834003190	Uncharacterized conserved protein [Function unknown]; Region: COG5607
266834003191	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834003192	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003193	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834003194	putative effector binding pocket; other site
266834003195	dimerization interface [polypeptide binding]; other site
266834003196	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834003197	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
266834003198	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
266834003199	potential catalytic triad [active]
266834003200	conserved cys residue [active]
266834003201	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
266834003202	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
266834003203	potential catalytic triad [active]
266834003204	conserved cys residue [active]
266834003205	Uncharacterized conserved protein [Function unknown]; Region: COG1359
266834003206	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834003207	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834003208	hypothetical protein; Provisional; Region: PRK06486
266834003209	intersubunit interface [polypeptide binding]; other site
266834003210	active site
266834003211	Zn2+ binding site [ion binding]; other site
266834003212	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
266834003213	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834003214	motif II; other site
266834003215	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834003216	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003217	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834003218	dimerization interface [polypeptide binding]; other site
266834003219	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834003220	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834003221	NAD(P) binding site [chemical binding]; other site
266834003222	active site
266834003223	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834003224	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003225	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834003226	putative effector binding pocket; other site
266834003227	dimerization interface [polypeptide binding]; other site
266834003228	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
266834003229	HicB family; Region: HicB; pfam05534
266834003230	SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839
266834003231	active site
266834003232	catalytic triad [active]
266834003233	oxyanion hole [active]
266834003234	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834003235	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834003236	TM-ABC transporter signature motif; other site
266834003237	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834003238	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834003239	TM-ABC transporter signature motif; other site
266834003240	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834003241	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834003242	Walker A/P-loop; other site
266834003243	ATP binding site [chemical binding]; other site
266834003244	Q-loop/lid; other site
266834003245	ABC transporter signature motif; other site
266834003246	Walker B; other site
266834003247	D-loop; other site
266834003248	H-loop/switch region; other site
266834003249	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834003250	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834003251	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
266834003252	putative ligand binding site [chemical binding]; other site
266834003253	SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839
266834003254	active site
266834003255	catalytic triad [active]
266834003256	oxyanion hole [active]
266834003257	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
266834003258	putative switch regulator; other site
266834003259	Transcriptional regulators [Transcription]; Region: MarR; COG1846
266834003260	non-specific DNA interactions [nucleotide binding]; other site
266834003261	DNA binding site [nucleotide binding]
266834003262	sequence specific DNA binding site [nucleotide binding]; other site
266834003263	putative cAMP binding site [chemical binding]; other site
266834003264	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
266834003265	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
266834003266	nucleotide binding site [chemical binding]; other site
266834003267	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834003268	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834003269	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
266834003270	putative dimer interface [polypeptide binding]; other site
266834003271	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834003272	Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172
266834003273	PLD-like domain; Region: PLDc_2; pfam13091
266834003274	putative active site [active]
266834003275	catalytic site [active]
266834003276	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
266834003277	PLD-like domain; Region: PLDc_2; pfam13091
266834003278	putative active site [active]
266834003279	catalytic site [active]
266834003280	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834003281	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834003282	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834003283	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003284	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834003285	dimerization interface [polypeptide binding]; other site
266834003286	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834003287	active site
266834003288	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
266834003289	MarR family; Region: MarR; pfam01047
266834003290	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
266834003291	Serine hydrolase; Region: Ser_hydrolase; cl17834
266834003292	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
266834003293	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
266834003294	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834003295	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003296	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834003297	putative effector binding pocket; other site
266834003298	dimerization interface [polypeptide binding]; other site
266834003299	Isochorismatase family; Region: Isochorismatase; pfam00857
266834003300	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
266834003301	catalytic triad [active]
266834003302	dimer interface [polypeptide binding]; other site
266834003303	conserved cis-peptide bond; other site
266834003304	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
266834003305	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
266834003306	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
266834003307	murein hydrolase B; Provisional; Region: PRK10760; cl17906
266834003308	Ubiquitin-like proteins; Region: UBQ; cl00155
266834003309	charged pocket; other site
266834003310	hydrophobic patch; other site
266834003311	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
266834003312	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
266834003313	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834003314	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
266834003315	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834003316	catalytic loop [active]
266834003317	iron binding site [ion binding]; other site
266834003318	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
266834003319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
266834003320	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
266834003321	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
266834003322	DDE superfamily endonuclease; Region: DDE_3; pfam13358
266834003323	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
266834003324	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
266834003325	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
266834003326	DNA-binding interface [nucleotide binding]; DNA binding site
266834003327	Homeodomain-like domain; Region: HTH_32; pfam13565
266834003328	Integrase core domain; Region: rve; pfam00665
266834003329	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834003330	DNA binding site [nucleotide binding]
266834003331	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834003332	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
266834003333	putative ligand binding site [chemical binding]; other site
266834003334	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
266834003335	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
266834003336	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
266834003337	[2Fe-2S] cluster binding site [ion binding]; other site
266834003338	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
266834003339	K+ potassium transporter; Region: K_trans; cl15781
266834003340	RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467
266834003341	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
266834003342	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
266834003343	Walker A motif; other site
266834003344	Walker A motif; other site
266834003345	ATP binding site [chemical binding]; other site
266834003346	Walker B motif; other site
266834003347	KaiC; Region: KaiC; pfam06745
266834003348	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
266834003349	Walker A motif; other site
266834003350	ATP binding site [chemical binding]; other site
266834003351	Walker B motif; other site
266834003352	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
266834003353	HWE histidine kinase; Region: HWE_HK; pfam07536
266834003354	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
266834003355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834003356	active site
266834003357	phosphorylation site [posttranslational modification]
266834003358	intermolecular recognition site; other site
266834003359	dimerization interface [polypeptide binding]; other site
266834003360	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
266834003361	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
266834003362	Walker A/P-loop; other site
266834003363	ATP binding site [chemical binding]; other site
266834003364	Q-loop/lid; other site
266834003365	ABC transporter signature motif; other site
266834003366	Walker B; other site
266834003367	D-loop; other site
266834003368	H-loop/switch region; other site
266834003369	TOBE-like domain; Region: TOBE_3; pfam12857
266834003370	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
266834003371	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
266834003372	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
266834003373	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
266834003374	Flavin binding site [chemical binding]; other site
266834003375	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834003376	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
266834003377	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834003378	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834003379	active site
266834003380	catalytic tetrad [active]
266834003381	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
266834003382	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834003383	Walker A/P-loop; other site
266834003384	ATP binding site [chemical binding]; other site
266834003385	Q-loop/lid; other site
266834003386	ABC transporter signature motif; other site
266834003387	Walker B; other site
266834003388	D-loop; other site
266834003389	H-loop/switch region; other site
266834003390	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
266834003391	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
266834003392	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834003393	Walker A/P-loop; other site
266834003394	ATP binding site [chemical binding]; other site
266834003395	Q-loop/lid; other site
266834003396	ABC transporter signature motif; other site
266834003397	Walker B; other site
266834003398	D-loop; other site
266834003399	H-loop/switch region; other site
266834003400	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834003401	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
266834003402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834003403	dimer interface [polypeptide binding]; other site
266834003404	conserved gate region; other site
266834003405	putative PBP binding loops; other site
266834003406	ABC-ATPase subunit interface; other site
266834003407	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834003408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834003409	dimer interface [polypeptide binding]; other site
266834003410	conserved gate region; other site
266834003411	putative PBP binding loops; other site
266834003412	ABC-ATPase subunit interface; other site
266834003413	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
266834003414	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
266834003415	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
266834003416	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
266834003417	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
266834003418	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
266834003419	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834003420	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
266834003421	NAD(P) binding site [chemical binding]; other site
266834003422	active site
266834003423	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
266834003424	hypothetical protein; Provisional; Region: PRK07236
266834003425	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
266834003426	Putative NADH-flavin reductase [General function prediction only]; Region: COG2910
266834003427	NADH(P)-binding; Region: NAD_binding_10; pfam13460
266834003428	NAD(P) binding site [chemical binding]; other site
266834003429	active site
266834003430	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
266834003431	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
266834003432	active site
266834003433	non-prolyl cis peptide bond; other site
266834003434	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
266834003435	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
266834003436	Moco binding site; other site
266834003437	metal coordination site [ion binding]; other site
266834003438	dimerization interface [polypeptide binding]; other site
266834003439	Fic family protein [Function unknown]; Region: COG3177
266834003440	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
266834003441	Fic/DOC family; Region: Fic; pfam02661
266834003442	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834003443	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003444	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834003445	putative effector binding pocket; other site
266834003446	dimerization interface [polypeptide binding]; other site
266834003447	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
266834003448	NmrA-like family; Region: NmrA; pfam05368
266834003449	NADP binding site [chemical binding]; other site
266834003450	active site
266834003451	regulatory binding site [polypeptide binding]; other site
266834003452	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
266834003453	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
266834003454	substrate binding site [chemical binding]; other site
266834003455	catalytic Zn binding site [ion binding]; other site
266834003456	NAD binding site [chemical binding]; other site
266834003457	structural Zn binding site [ion binding]; other site
266834003458	dimer interface [polypeptide binding]; other site
266834003459	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834003460	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
266834003461	putative C-terminal domain interface [polypeptide binding]; other site
266834003462	putative GSH binding site (G-site) [chemical binding]; other site
266834003463	putative dimer interface [polypeptide binding]; other site
266834003464	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
266834003465	putative N-terminal domain interface [polypeptide binding]; other site
266834003466	putative dimer interface [polypeptide binding]; other site
266834003467	putative substrate binding pocket (H-site) [chemical binding]; other site
266834003468	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
266834003469	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
266834003470	[2Fe-2S] cluster binding site [ion binding]; other site
266834003471	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
266834003472	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
266834003473	FMN-binding pocket [chemical binding]; other site
266834003474	flavin binding motif; other site
266834003475	phosphate binding motif [ion binding]; other site
266834003476	beta-alpha-beta structure motif; other site
266834003477	NAD binding pocket [chemical binding]; other site
266834003478	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834003479	catalytic loop [active]
266834003480	iron binding site [ion binding]; other site
266834003481	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
266834003482	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
266834003483	hydrophobic ligand binding site; other site
266834003484	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
266834003485	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
266834003486	hydrophobic ligand binding site; other site
266834003487	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834003488	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
266834003489	TM-ABC transporter signature motif; other site
266834003490	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834003491	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
266834003492	TM-ABC transporter signature motif; other site
266834003493	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
266834003494	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834003495	Walker A/P-loop; other site
266834003496	ATP binding site [chemical binding]; other site
266834003497	Q-loop/lid; other site
266834003498	ABC transporter signature motif; other site
266834003499	Walker B; other site
266834003500	D-loop; other site
266834003501	H-loop/switch region; other site
266834003502	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834003503	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
266834003504	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
266834003505	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
266834003506	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
266834003507	hydrophobic ligand binding site; other site
266834003508	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834003509	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834003510	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834003511	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
266834003512	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
266834003513	dimer interface [polypeptide binding]; other site
266834003514	active site
266834003515	glycine-pyridoxal phosphate binding site [chemical binding]; other site
266834003516	folate binding site [chemical binding]; other site
266834003517	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
266834003518	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
266834003519	dimerization interface [polypeptide binding]; other site
266834003520	ligand binding site [chemical binding]; other site
266834003521	NADP binding site [chemical binding]; other site
266834003522	catalytic site [active]
266834003523	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
266834003524	homodimer interface [polypeptide binding]; other site
266834003525	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834003526	catalytic residue [active]
266834003527	Formyltetrahydrofolate hydrolase [Nucleotide transport and metabolism]; Region: PurU; COG0788
266834003528	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
266834003529	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
266834003530	putative active site [active]
266834003531	putative substrate binding site [chemical binding]; other site
266834003532	putative cosubstrate binding site; other site
266834003533	catalytic site [active]
266834003534	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
266834003535	FAD binding site [chemical binding]; other site
266834003536	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
266834003537	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
266834003538	RepB plasmid partitioning protein; Region: RepB; pfam07506
266834003539	ParB-like nuclease domain; Region: ParB; smart00470
266834003540	RepB plasmid partitioning protein; Region: RepB; pfam07506
266834003541	Predicted transcriptional regulator [Transcription]; Region: COG2944
266834003542	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834003543	non-specific DNA binding site [nucleotide binding]; other site
266834003544	salt bridge; other site
266834003545	sequence-specific DNA binding site [nucleotide binding]; other site
266834003546	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834003547	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834003548	active site
266834003549	catalytic tetrad [active]
266834003550	Uncharacterized conserved protein [Function unknown]; Region: COG1262
266834003551	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
266834003552	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834003553	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834003554	short chain dehydrogenase; Provisional; Region: PRK06500
266834003555	classical (c) SDRs; Region: SDR_c; cd05233
266834003556	NAD(P) binding site [chemical binding]; other site
266834003557	active site
266834003558	Predicted transcriptional regulator [Transcription]; Region: COG4190
266834003559	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834003560	dimerization interface [polypeptide binding]; other site
266834003561	putative DNA binding site [nucleotide binding]; other site
266834003562	putative Zn2+ binding site [ion binding]; other site
266834003563	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
266834003564	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834003565	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
266834003566	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
266834003567	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
266834003568	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
266834003569	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
266834003570	Int/Topo IB signature motif; other site
266834003571	INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187
266834003572	Int/Topo IB signature motif; other site
266834003573	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
266834003574	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
266834003575	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
266834003576	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
266834003577	active site
266834003578	DNA binding site [nucleotide binding]
266834003579	Int/Topo IB signature motif; other site
266834003580	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834003581	Transposase; Region: HTH_Tnp_1; pfam01527
266834003582	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834003583	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834003584	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
266834003585	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
266834003586	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
266834003587	Walker A/P-loop; other site
266834003588	ATP binding site [chemical binding]; other site
266834003589	Q-loop/lid; other site
266834003590	ABC transporter signature motif; other site
266834003591	Walker B; other site
266834003592	D-loop; other site
266834003593	H-loop/switch region; other site
266834003594	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834003595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834003596	dimer interface [polypeptide binding]; other site
266834003597	conserved gate region; other site
266834003598	putative PBP binding loops; other site
266834003599	ABC-ATPase subunit interface; other site
266834003600	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834003601	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
266834003602	substrate binding pocket [chemical binding]; other site
266834003603	membrane-bound complex binding site; other site
266834003604	hinge residues; other site
266834003605	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
266834003606	homotrimer interaction site [polypeptide binding]; other site
266834003607	putative active site [active]
266834003608	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834003609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834003610	putative PBP binding loops; other site
266834003611	ABC-ATPase subunit interface; other site
266834003612	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
266834003613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834003614	dimer interface [polypeptide binding]; other site
266834003615	conserved gate region; other site
266834003616	putative PBP binding loops; other site
266834003617	ABC-ATPase subunit interface; other site
266834003618	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
266834003619	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834003620	Walker A/P-loop; other site
266834003621	ATP binding site [chemical binding]; other site
266834003622	Q-loop/lid; other site
266834003623	ABC transporter signature motif; other site
266834003624	Walker B; other site
266834003625	D-loop; other site
266834003626	H-loop/switch region; other site
266834003627	TOBE domain; Region: TOBE; pfam03459
266834003628	TOBE domain; Region: TOBE_2; pfam08402
266834003629	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
266834003630	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
266834003631	thiamine pyrophosphate protein; Validated; Region: PRK08199
266834003632	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
266834003633	PYR/PP interface [polypeptide binding]; other site
266834003634	dimer interface [polypeptide binding]; other site
266834003635	TPP binding site [chemical binding]; other site
266834003636	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
266834003637	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
266834003638	TPP-binding site [chemical binding]; other site
266834003639	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
266834003640	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
266834003641	NAD(P) binding site [chemical binding]; other site
266834003642	catalytic residues [active]
266834003643	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
266834003644	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834003645	DNA-binding site [nucleotide binding]; DNA binding site
266834003646	UTRA domain; Region: UTRA; pfam07702
266834003647	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
266834003648	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
266834003649	Flavoprotein; Region: Flavoprotein; pfam02441
266834003650	hypothetical protein; Provisional; Region: PRK07475
266834003651	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834003652	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834003653	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
266834003654	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
266834003655	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
266834003656	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834003657	DNA-binding site [nucleotide binding]; DNA binding site
266834003658	UTRA domain; Region: UTRA; pfam07702
266834003659	Protein of unknown function (DUF2390); Region: DUF2390; cl02376
266834003660	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487
266834003661	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
266834003662	Bacteriophage protein gp37 [Function unknown]; Region: COG4422
266834003663	Superfamily II helicase [General function prediction only]; Region: COG1204
266834003664	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
266834003665	ATP binding site [chemical binding]; other site
266834003666	putative Mg++ binding site [ion binding]; other site
266834003667	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
266834003668	Protein of unknown function (DUF904); Region: DUF904; pfam06005
266834003669	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
266834003670	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
266834003671	putative active site [active]
266834003672	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
266834003673	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
266834003674	active site
266834003675	DNA binding site [nucleotide binding]
266834003676	Int/Topo IB signature motif; other site
266834003677	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
266834003678	putative dimer interface [polypeptide binding]; other site
266834003679	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834003680	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
266834003681	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
266834003682	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
266834003683	Uncharacterized conserved protein [Function unknown]; Region: COG5654
266834003684	Uncharacterized conserved protein [Function unknown]; Region: COG5642
266834003685	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
266834003686	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003687	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
266834003688	dimerization interface [polypeptide binding]; other site
266834003689	substrate binding pocket [chemical binding]; other site
266834003690	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
266834003691	homotrimer interaction site [polypeptide binding]; other site
266834003692	putative active site [active]
266834003693	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
266834003694	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
266834003695	active site
266834003696	FMN binding site [chemical binding]; other site
266834003697	substrate binding site [chemical binding]; other site
266834003698	putative catalytic residue [active]
266834003699	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
266834003700	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003701	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834003702	dimerization interface [polypeptide binding]; other site
266834003703	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
266834003704	Transglycosylase; Region: Transgly; pfam00912
266834003705	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
266834003706	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
266834003707	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
266834003708	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
266834003709	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
266834003710	Bacterial SH3 domain; Region: SH3_3; pfam08239
266834003711	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
266834003712	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834003713	metal binding site [ion binding]; metal-binding site
266834003714	active site
266834003715	I-site; other site
266834003716	non-specific DNA interactions [nucleotide binding]; other site
266834003717	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
266834003718	DNA binding site [nucleotide binding]
266834003719	sequence specific DNA binding site [nucleotide binding]; other site
266834003720	putative cAMP binding site [chemical binding]; other site
266834003721	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
266834003722	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
266834003723	nucleotide binding site [chemical binding]; other site
266834003724	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
266834003725	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834003726	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834003727	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
266834003728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834003729	dimer interface [polypeptide binding]; other site
266834003730	conserved gate region; other site
266834003731	putative PBP binding loops; other site
266834003732	ABC-ATPase subunit interface; other site
266834003733	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834003734	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834003735	dimer interface [polypeptide binding]; other site
266834003736	conserved gate region; other site
266834003737	putative PBP binding loops; other site
266834003738	ABC-ATPase subunit interface; other site
266834003739	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
266834003740	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834003741	Walker A/P-loop; other site
266834003742	ATP binding site [chemical binding]; other site
266834003743	Q-loop/lid; other site
266834003744	ABC transporter signature motif; other site
266834003745	Walker B; other site
266834003746	D-loop; other site
266834003747	H-loop/switch region; other site
266834003748	TOBE domain; Region: TOBE_2; pfam08402
266834003749	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834003750	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834003751	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
266834003752	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834003753	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834003754	active site
266834003755	catalytic tetrad [active]
266834003756	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
266834003757	active site
266834003758	NTP binding site [chemical binding]; other site
266834003759	metal binding triad [ion binding]; metal-binding site
266834003760	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
266834003761	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
266834003762	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
266834003763	putative C-terminal domain interface [polypeptide binding]; other site
266834003764	putative GSH binding site (G-site) [chemical binding]; other site
266834003765	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834003766	putative dimer interface [polypeptide binding]; other site
266834003767	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
266834003768	dimer interface [polypeptide binding]; other site
266834003769	N-terminal domain interface [polypeptide binding]; other site
266834003770	putative substrate binding pocket (H-site) [chemical binding]; other site
266834003771	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
266834003772	Part of AAA domain; Region: AAA_19; pfam13245
266834003773	Family description; Region: UvrD_C_2; pfam13538
266834003774	Ion channel; Region: Ion_trans_2; pfam07885
266834003775	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834003776	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834003777	active site
266834003778	phosphorylation site [posttranslational modification]
266834003779	intermolecular recognition site; other site
266834003780	dimerization interface [polypeptide binding]; other site
266834003781	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834003782	DNA binding site [nucleotide binding]
266834003783	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
266834003784	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
266834003785	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
266834003786	Ligand Binding Site [chemical binding]; other site
266834003787	GAF domain; Region: GAF_3; pfam13492
266834003788	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834003789	dimer interface [polypeptide binding]; other site
266834003790	phosphorylation site [posttranslational modification]
266834003791	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834003792	ATP binding site [chemical binding]; other site
266834003793	Mg2+ binding site [ion binding]; other site
266834003794	G-X-G motif; other site
266834003795	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
266834003796	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
266834003797	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
266834003798	Soluble P-type ATPase [General function prediction only]; Region: COG4087
266834003799	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
266834003800	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
266834003801	muropeptide transporter; Validated; Region: ampG; cl17669
266834003802	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
266834003803	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834003804	inhibitor-cofactor binding pocket; inhibition site
266834003805	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834003806	catalytic residue [active]
266834003807	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
266834003808	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834003809	catalytic residue [active]
266834003810	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
266834003811	IucA / IucC family; Region: IucA_IucC; pfam04183
266834003812	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
266834003813	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
266834003814	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
266834003815	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
266834003816	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
266834003817	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
266834003818	IucA / IucC family; Region: IucA_IucC; pfam04183
266834003819	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
266834003820	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834003821	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834003822	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
266834003823	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
266834003824	N-terminal plug; other site
266834003825	ligand-binding site [chemical binding]; other site
266834003826	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
266834003827	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
266834003828	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834003829	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834003830	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
266834003831	putative effector binding pocket; other site
266834003832	putative dimerization interface [polypeptide binding]; other site
266834003833	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
266834003834	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834003835	NAD(P) binding site [chemical binding]; other site
266834003836	active site
266834003837	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
266834003838	Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512
266834003839	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834003840	S-adenosylmethionine binding site [chemical binding]; other site
266834003841	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
266834003842	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834003843	catalytic loop [active]
266834003844	iron binding site [ion binding]; other site
266834003845	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
266834003846	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
266834003847	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
266834003848	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
266834003849	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
266834003850	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834003851	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
266834003852	active site
266834003853	DNA polymerase IV; Validated; Region: PRK02406
266834003854	DNA binding site [nucleotide binding]
266834003855	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834003856	cyclase homology domain; Region: CHD; cd07302
266834003857	nucleotidyl binding site; other site
266834003858	metal binding site [ion binding]; metal-binding site
266834003859	dimer interface [polypeptide binding]; other site
266834003860	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
266834003861	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
266834003862	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
266834003863	putative ligand binding site [chemical binding]; other site
266834003864	amidase; Provisional; Region: PRK07869
266834003865	Amidase; Region: Amidase; cl11426
266834003866	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
266834003867	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834003868	Walker A/P-loop; other site
266834003869	ATP binding site [chemical binding]; other site
266834003870	Q-loop/lid; other site
266834003871	ABC transporter signature motif; other site
266834003872	Walker B; other site
266834003873	D-loop; other site
266834003874	H-loop/switch region; other site
266834003875	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834003876	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834003877	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
266834003878	TM-ABC transporter signature motif; other site
266834003879	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834003880	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
266834003881	TM-ABC transporter signature motif; other site
266834003882	cytosine deaminase; Validated; Region: PRK07572
266834003883	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
266834003884	active site
266834003885	Transcriptional activator [Transcription]; Region: ChrR; COG3806
266834003886	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
266834003887	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
266834003888	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834003889	Homeodomain-like domain; Region: HTH_32; pfam13565
266834003890	DDE superfamily endonuclease; Region: DDE_3; pfam13358
266834003891	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
266834003892	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834003893	putative substrate translocation pore; other site
266834003894	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
266834003895	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
266834003896	dimer interface [polypeptide binding]; other site
266834003897	active site
266834003898	heme binding site [chemical binding]; other site
266834003899	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
266834003900	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834003901	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834003902	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
266834003903	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
266834003904	NADP binding site [chemical binding]; other site
266834003905	dimer interface [polypeptide binding]; other site
266834003906	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
266834003907	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834003908	Walker A/P-loop; other site
266834003909	ATP binding site [chemical binding]; other site
266834003910	Q-loop/lid; other site
266834003911	ABC transporter signature motif; other site
266834003912	Walker B; other site
266834003913	D-loop; other site
266834003914	H-loop/switch region; other site
266834003915	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
266834003916	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834003917	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834003918	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
266834003919	replication initiation protein RepC; Provisional; Region: PRK13824
266834003920	Replication protein C N-terminal domain; Region: RP-C; pfam03428
266834003921	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
266834003922	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
266834003923	ParB-like nuclease domain; Region: ParB; smart00470
266834003924	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
266834003925	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
266834003926	P-loop; other site
266834003927	Magnesium ion binding site [ion binding]; other site
266834003928	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
266834003929	Magnesium ion binding site [ion binding]; other site
266834003930	PEP synthetase regulatory protein; Provisional; Region: PRK05339
266834003931	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
266834003932	active site
266834003933	dimer interface [polypeptide binding]; other site
266834003934	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
266834003935	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
266834003936	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
266834003937	shikimate binding site; other site
266834003938	NAD(P) binding site [chemical binding]; other site
266834003939	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
266834003940	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
266834003941	CoA-binding site [chemical binding]; other site
266834003942	ATP-binding [chemical binding]; other site
266834003943	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
266834003944	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
266834003945	active site
266834003946	catalytic site [active]
266834003947	substrate binding site [chemical binding]; other site
266834003948	Preprotein translocase subunit SecB [Intracellular trafficking and secretion]; Region: SecB; COG1952
266834003949	SecA binding site; other site
266834003950	Preprotein binding site; other site
266834003951	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
266834003952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
266834003953	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
266834003954	MltA specific insert domain; Region: MltA; pfam03562
266834003955	3D domain; Region: 3D; pfam06725
266834003956	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
266834003957	Smr domain; Region: Smr; pfam01713
266834003958	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
266834003959	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834003960	non-specific DNA binding site [nucleotide binding]; other site
266834003961	salt bridge; other site
266834003962	sequence-specific DNA binding site [nucleotide binding]; other site
266834003963	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
266834003964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834003965	Mg2+ binding site [ion binding]; other site
266834003966	G-X-G motif; other site
266834003967	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
266834003968	anchoring element; other site
266834003969	dimer interface [polypeptide binding]; other site
266834003970	ATP binding site [chemical binding]; other site
266834003971	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
266834003972	active site
266834003973	putative metal-binding site [ion binding]; other site
266834003974	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
266834003975	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
266834003976	putative FMN binding site [chemical binding]; other site
266834003977	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
266834003978	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
266834003979	tetramerization interface [polypeptide binding]; other site
266834003980	NAD(P) binding site [chemical binding]; other site
266834003981	catalytic residues [active]
266834003982	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
266834003983	Transposase; Region: DEDD_Tnp_IS110; pfam01548
266834003984	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
266834003985	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
266834003986	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
266834003987	DNA-binding site [nucleotide binding]; DNA binding site
266834003988	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834003989	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
266834003990	DNA-binding site [nucleotide binding]; DNA binding site
266834003991	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
266834003992	galactarate dehydratase; Region: galactar-dH20; TIGR03248
266834003993	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
266834003994	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
266834003995	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834003996	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834003997	active site
266834003998	catalytic tetrad [active]
266834003999	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
266834004000	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
266834004001	putative ligand binding site [chemical binding]; other site
266834004002	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834004003	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834004004	Walker A/P-loop; other site
266834004005	ATP binding site [chemical binding]; other site
266834004006	Q-loop/lid; other site
266834004007	ABC transporter signature motif; other site
266834004008	Walker B; other site
266834004009	D-loop; other site
266834004010	H-loop/switch region; other site
266834004011	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834004012	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834004013	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834004014	TM-ABC transporter signature motif; other site
266834004015	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
266834004016	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
266834004017	putative NAD(P) binding site [chemical binding]; other site
266834004018	catalytic Zn binding site [ion binding]; other site
266834004019	structural Zn binding site [ion binding]; other site
266834004020	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
266834004021	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
266834004022	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
266834004023	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
266834004024	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
266834004025	active site
266834004026	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
266834004027	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
266834004028	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834004029	catalytic residue [active]
266834004030	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
266834004031	substrate binding site [chemical binding]; other site
266834004032	active site
266834004033	catalytic residues [active]
266834004034	heterodimer interface [polypeptide binding]; other site
266834004035	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
266834004036	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
266834004037	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
266834004038	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
266834004039	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
266834004040	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
266834004041	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
266834004042	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
266834004043	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
266834004044	catalytic residues [active]
266834004045	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
266834004046	Family description; Region: UvrD_C_2; pfam13538
266834004047	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
266834004048	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
266834004049	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
266834004050	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
266834004051	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
266834004052	Substrate binding site; other site
266834004053	metal-binding site
266834004054	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
266834004055	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
266834004056	Phosphotransferase enzyme family; Region: APH; pfam01636
266834004057	PAS fold; Region: PAS_7; pfam12860
266834004058	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
266834004059	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834004060	dimer interface [polypeptide binding]; other site
266834004061	phosphorylation site [posttranslational modification]
266834004062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834004063	ATP binding site [chemical binding]; other site
266834004064	Mg2+ binding site [ion binding]; other site
266834004065	G-X-G motif; other site
266834004066	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
266834004067	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
266834004068	homotetramer interface [polypeptide binding]; other site
266834004069	ligand binding site [chemical binding]; other site
266834004070	catalytic site [active]
266834004071	NAD binding site [chemical binding]; other site
266834004072	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
266834004073	dimerization domain swap beta strand [polypeptide binding]; other site
266834004074	regulatory protein interface [polypeptide binding]; other site
266834004075	active site
266834004076	regulatory phosphorylation site [posttranslational modification]; other site
266834004077	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
266834004078	active pocket/dimerization site; other site
266834004079	active site
266834004080	phosphorylation site [posttranslational modification]
266834004081	Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493
266834004082	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
266834004083	Hpr binding site; other site
266834004084	active site
266834004085	homohexamer subunit interaction site [polypeptide binding]; other site
266834004086	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
266834004087	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
266834004088	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834004089	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
266834004090	dimerization interface [polypeptide binding]; other site
266834004091	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834004092	dimer interface [polypeptide binding]; other site
266834004093	phosphorylation site [posttranslational modification]
266834004094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834004095	ATP binding site [chemical binding]; other site
266834004096	Mg2+ binding site [ion binding]; other site
266834004097	G-X-G motif; other site
266834004098	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834004099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834004100	active site
266834004101	phosphorylation site [posttranslational modification]
266834004102	intermolecular recognition site; other site
266834004103	dimerization interface [polypeptide binding]; other site
266834004104	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834004105	DNA binding site [nucleotide binding]
266834004106	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
266834004107	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
266834004108	active site
266834004109	substrate-binding site [chemical binding]; other site
266834004110	metal-binding site [ion binding]
266834004111	ATP binding site [chemical binding]; other site
266834004112	hypothetical protein; Provisional; Region: PRK09256
266834004113	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
266834004114	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
266834004115	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
266834004116	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
266834004117	pantothenate kinase; Provisional; Region: PRK05439
266834004118	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
266834004119	ATP-binding site [chemical binding]; other site
266834004120	CoA-binding site [chemical binding]; other site
266834004121	Mg2+-binding site [ion binding]; other site
266834004122	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
266834004123	metal binding site [ion binding]; metal-binding site
266834004124	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
266834004125	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
266834004126	substrate binding site [chemical binding]; other site
266834004127	glutamase interaction surface [polypeptide binding]; other site
266834004128	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
266834004129	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
266834004130	catalytic residues [active]
266834004131	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
266834004132	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
266834004133	putative active site [active]
266834004134	oxyanion strand; other site
266834004135	catalytic triad [active]
266834004136	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
266834004137	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
266834004138	putative active site pocket [active]
266834004139	4-fold oligomerization interface [polypeptide binding]; other site
266834004140	metal binding residues [ion binding]; metal-binding site
266834004141	3-fold/trimer interface [polypeptide binding]; other site
266834004142	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
266834004143	active site
266834004144	HslU subunit interaction site [polypeptide binding]; other site
266834004145	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
266834004146	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
266834004147	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
266834004148	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
266834004149	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834004150	Walker A motif; other site
266834004151	ATP binding site [chemical binding]; other site
266834004152	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
266834004153	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
266834004154	Protein of unknown function (DUF1402); Region: DUF1402; pfam07182
266834004155	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
266834004156	Cytochrome P450; Region: p450; cl12078
266834004157	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
266834004158	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
266834004159	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
266834004160	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
266834004161	active site
266834004162	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
266834004163	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
266834004164	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5321
266834004165	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
266834004166	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834004167	active site
266834004168	phosphorylation site [posttranslational modification]
266834004169	intermolecular recognition site; other site
266834004170	dimerization interface [polypeptide binding]; other site
266834004171	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
266834004172	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834004173	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834004174	dimer interface [polypeptide binding]; other site
266834004175	phosphorylation site [posttranslational modification]
266834004176	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834004177	ATP binding site [chemical binding]; other site
266834004178	Mg2+ binding site [ion binding]; other site
266834004179	G-X-G motif; other site
266834004180	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
266834004181	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
266834004182	ATP binding site [chemical binding]; other site
266834004183	putative Mg++ binding site [ion binding]; other site
266834004184	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
266834004185	nucleotide binding region [chemical binding]; other site
266834004186	ATP-binding site [chemical binding]; other site
266834004187	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
266834004188	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
266834004189	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834004190	Walker A/P-loop; other site
266834004191	ATP binding site [chemical binding]; other site
266834004192	Q-loop/lid; other site
266834004193	ABC transporter signature motif; other site
266834004194	Walker B; other site
266834004195	D-loop; other site
266834004196	H-loop/switch region; other site
266834004197	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135
266834004198	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834004199	dimer interface [polypeptide binding]; other site
266834004200	conserved gate region; other site
266834004201	putative PBP binding loops; other site
266834004202	ABC-ATPase subunit interface; other site
266834004203	hypothetical protein; Provisional; Region: PRK11622
266834004204	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
266834004205	rrn OR SMc02938; predicted by Homology
266834004206	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
266834004207	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
266834004208	O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080
266834004209	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
266834004210	homodimer interface [polypeptide binding]; other site
266834004211	substrate-cofactor binding pocket; other site
266834004212	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834004213	catalytic residue [active]
266834004214	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834004215	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834004216	LysR substrate binding domain; Region: LysR_substrate; pfam03466
266834004217	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
266834004218	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
266834004219	HPP family; Region: HPP; pfam04982
266834004220	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
266834004221	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
266834004222	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
266834004223	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
266834004224	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
266834004225	homodimer interface [polypeptide binding]; other site
266834004226	NADP binding site [chemical binding]; other site
266834004227	substrate binding site [chemical binding]; other site
266834004228	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
266834004229	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
266834004230	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
266834004231	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
266834004232	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
266834004233	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
266834004234	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834004235	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
266834004236	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
266834004237	conserved cys residue [active]
266834004238	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834004239	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
266834004240	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
266834004241	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
266834004242	putative active site [active]
266834004243	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
266834004244	domain_subunit interface; other site
266834004245	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
266834004246	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
266834004247	active site
266834004248	FMN binding site [chemical binding]; other site
266834004249	substrate binding site [chemical binding]; other site
266834004250	3Fe-4S cluster binding site [ion binding]; other site
266834004251	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
266834004252	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
266834004253	ethanolamine permease; Region: 2A0305; TIGR00908
266834004254	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
266834004255	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834004256	non-specific DNA binding site [nucleotide binding]; other site
266834004257	salt bridge; other site
266834004258	sequence-specific DNA binding site [nucleotide binding]; other site
266834004259	Cupin domain; Region: Cupin_2; pfam07883
266834004260	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
266834004261	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
266834004262	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
266834004263	putative active site [active]
266834004264	putative substrate binding site [chemical binding]; other site
266834004265	putative cosubstrate binding site; other site
266834004266	catalytic site [active]
266834004267	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
266834004268	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
266834004269	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
266834004270	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
266834004271	FMN-binding pocket [chemical binding]; other site
266834004272	flavin binding motif; other site
266834004273	phosphate binding motif [ion binding]; other site
266834004274	beta-alpha-beta structure motif; other site
266834004275	NAD binding pocket [chemical binding]; other site
266834004276	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834004277	catalytic loop [active]
266834004278	iron binding site [ion binding]; other site
266834004279	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
266834004280	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
266834004281	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
266834004282	Uncharacterized conserved protein [Function unknown]; Region: COG3665
266834004283	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
266834004284	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
266834004285	Amino acid permease; Region: AA_permease_2; pfam13520
266834004286	putative phosphoketolase; Provisional; Region: PRK05261
266834004287	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
266834004288	TPP-binding site; other site
266834004289	XFP C-terminal domain; Region: XFP_C; pfam09363
266834004290	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834004291	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
266834004292	NAD(P) binding site [chemical binding]; other site
266834004293	active site
266834004294	dihydroxy-acid dehydratase; Provisional; Region: PRK13016
266834004295	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834004296	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834004297	DNA-binding site [nucleotide binding]; DNA binding site
266834004298	FCD domain; Region: FCD; pfam07729
266834004299	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
266834004300	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834004301	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
266834004302	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
266834004303	N-terminal domain interface [polypeptide binding]; other site
266834004304	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834004305	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834004306	Walker A/P-loop; other site
266834004307	ATP binding site [chemical binding]; other site
266834004308	Q-loop/lid; other site
266834004309	ABC transporter signature motif; other site
266834004310	Walker B; other site
266834004311	D-loop; other site
266834004312	H-loop/switch region; other site
266834004313	TOBE domain; Region: TOBE_2; pfam08402
266834004314	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834004315	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834004316	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
266834004317	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834004318	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834004319	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
266834004320	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834004321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834004322	dimer interface [polypeptide binding]; other site
266834004323	conserved gate region; other site
266834004324	putative PBP binding loops; other site
266834004325	ABC-ATPase subunit interface; other site
266834004326	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
266834004327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834004328	dimer interface [polypeptide binding]; other site
266834004329	conserved gate region; other site
266834004330	putative PBP binding loops; other site
266834004331	ABC-ATPase subunit interface; other site
266834004332	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834004333	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834004334	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
266834004335	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834004336	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834004337	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834004338	Protein of unknown function (DUF993); Region: DUF993; pfam06187
266834004339	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
266834004340	metal binding site [ion binding]; metal-binding site
266834004341	substrate binding pocket [chemical binding]; other site
266834004342	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
266834004343	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
266834004344	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834004345	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834004346	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
266834004347	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
266834004348	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
266834004349	metal-binding site [ion binding]
266834004350	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
266834004351	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
266834004352	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834004353	Walker A/P-loop; other site
266834004354	ATP binding site [chemical binding]; other site
266834004355	Q-loop/lid; other site
266834004356	ABC transporter signature motif; other site
266834004357	Walker B; other site
266834004358	D-loop; other site
266834004359	H-loop/switch region; other site
266834004360	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834004361	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834004362	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
266834004363	TM-ABC transporter signature motif; other site
266834004364	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834004365	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
266834004366	TM-ABC transporter signature motif; other site
266834004367	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
266834004368	active site
266834004369	catalytic motif [active]
266834004370	Zn binding site [ion binding]; other site
266834004371	purine nucleoside phosphorylase; Provisional; Region: PRK08202
266834004372	thymidine phosphorylase; Region: T_phosphoryl; TIGR02643
266834004373	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
266834004374	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
266834004375	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
266834004376	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
266834004377	active site
266834004378	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
266834004379	adenosine deaminase; Provisional; Region: PRK09358
266834004380	active site
266834004381	phosphopentomutase; Provisional; Region: PRK05362
266834004382	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
266834004383	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
266834004384	TadE-like protein; Region: TadE; pfam07811
266834004385	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
266834004386	TadE-like protein; Region: TadE; pfam07811
266834004387	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
266834004388	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
266834004389	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
266834004390	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
266834004391	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
266834004392	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
266834004393	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
266834004394	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
266834004395	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
266834004396	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
266834004397	BON domain; Region: BON; pfam04972
266834004398	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
266834004399	Type IV pili component [Cell motility and secretion]; Region: COG5461
266834004400	pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522
266834004401	AAA domain; Region: AAA_31; pfam13614
266834004402	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
266834004403	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
266834004404	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
266834004405	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
266834004406	ATP binding site [chemical binding]; other site
266834004407	Walker A motif; other site
266834004408	hexamer interface [polypeptide binding]; other site
266834004409	Walker B motif; other site
266834004410	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
266834004411	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
266834004412	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
266834004413	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
266834004414	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
266834004415	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
266834004416	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
266834004417	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
266834004418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834004419	TPR motif; other site
266834004420	binding surface
266834004421	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
266834004422	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
266834004423	interface (dimer of trimers) [polypeptide binding]; other site
266834004424	Substrate-binding/catalytic site; other site
266834004425	Zn-binding sites [ion binding]; other site
266834004426	Transcriptional regulators [Transcription]; Region: MarR; COG1846
266834004427	MarR family; Region: MarR; pfam01047
266834004428	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
266834004429	NlpC/P60 family; Region: NLPC_P60; cl17555
266834004430	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
266834004431	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
266834004432	putative ligand binding site [chemical binding]; other site
266834004433	NAD binding site [chemical binding]; other site
266834004434	dimerization interface [polypeptide binding]; other site
266834004435	catalytic site [active]
266834004436	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
266834004437	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834004438	Walker A/P-loop; other site
266834004439	ATP binding site [chemical binding]; other site
266834004440	Q-loop/lid; other site
266834004441	ABC transporter signature motif; other site
266834004442	Walker B; other site
266834004443	D-loop; other site
266834004444	H-loop/switch region; other site
266834004445	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
266834004446	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834004447	Walker A/P-loop; other site
266834004448	ATP binding site [chemical binding]; other site
266834004449	Q-loop/lid; other site
266834004450	ABC transporter signature motif; other site
266834004451	Walker B; other site
266834004452	D-loop; other site
266834004453	H-loop/switch region; other site
266834004454	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834004455	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
266834004456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834004457	dimer interface [polypeptide binding]; other site
266834004458	conserved gate region; other site
266834004459	putative PBP binding loops; other site
266834004460	ABC-ATPase subunit interface; other site
266834004461	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
266834004462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834004463	dimer interface [polypeptide binding]; other site
266834004464	conserved gate region; other site
266834004465	putative PBP binding loops; other site
266834004466	ABC-ATPase subunit interface; other site
266834004467	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
266834004468	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
266834004469	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
266834004470	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
266834004471	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
266834004472	active site
266834004473	dimer interfaces [polypeptide binding]; other site
266834004474	catalytic residues [active]
266834004475	glucokinase; Provisional; Region: glk; PRK00292
266834004476	glucokinase, proteobacterial type; Region: glk; TIGR00749
266834004477	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
266834004478	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834004479	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
266834004480	Walker A/P-loop; other site
266834004481	ATP binding site [chemical binding]; other site
266834004482	Q-loop/lid; other site
266834004483	ABC transporter signature motif; other site
266834004484	Walker B; other site
266834004485	D-loop; other site
266834004486	H-loop/switch region; other site
266834004487	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
266834004488	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
266834004489	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
266834004490	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
266834004491	catalytic core [active]
266834004492	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834004493	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834004494	MULE transposase domain; Region: MULE; pfam10551
266834004495	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834004496	MULE transposase domain; Region: MULE; pfam10551
266834004497	Helix-turn-helix domain; Region: HTH_18; pfam12833
266834004498	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
266834004499	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
266834004500	DNA binding site [nucleotide binding]
266834004501	active site
266834004502	Integral membrane protein [Function unknown]; Region: COG5488
266834004503	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
266834004504	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
266834004505	minor groove reading motif; other site
266834004506	helix-hairpin-helix signature motif; other site
266834004507	substrate binding pocket [chemical binding]; other site
266834004508	active site
266834004509	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
266834004510	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834004511	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
266834004512	putative dimer interface [polypeptide binding]; other site
266834004513	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834004514	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
266834004515	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
266834004516	substrate binding site [chemical binding]; other site
266834004517	ATP binding site [chemical binding]; other site
266834004518	Predicted kinase [General function prediction only]; Region: COG0645
266834004519	AAA domain; Region: AAA_17; pfam13207
266834004520	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
266834004521	Bacterial SH3 domain; Region: SH3_4; pfam06347
266834004522	Bacterial SH3 domain; Region: SH3_4; pfam06347
266834004523	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
266834004524	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
266834004525	dimerization interface [polypeptide binding]; other site
266834004526	ligand binding site [chemical binding]; other site
266834004527	NADP binding site [chemical binding]; other site
266834004528	catalytic site [active]
266834004529	5'-3' exonuclease; Region: 53EXOc; smart00475
266834004530	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
266834004531	active site
266834004532	metal binding site 1 [ion binding]; metal-binding site
266834004533	putative 5' ssDNA interaction site; other site
266834004534	metal binding site 3; metal-binding site
266834004535	metal binding site 2 [ion binding]; metal-binding site
266834004536	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
266834004537	putative DNA binding site [nucleotide binding]; other site
266834004538	putative metal binding site [ion binding]; other site
266834004539	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
266834004540	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
266834004541	active site
266834004542	catalytic site [active]
266834004543	substrate binding site [chemical binding]; other site
266834004544	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
266834004545	active site
266834004546	DNA binding site [nucleotide binding]
266834004547	catalytic site [active]
266834004548	MarR family; Region: MarR; pfam01047
266834004549	hypothetical protein; Validated; Region: PRK09104
266834004550	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
266834004551	metal binding site [ion binding]; metal-binding site
266834004552	putative dimer interface [polypeptide binding]; other site
266834004553	Predicted integral membrane protein [Function unknown]; Region: COG0392
266834004554	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
266834004555	EamA-like transporter family; Region: EamA; pfam00892
266834004556	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
266834004557	Transglycosylase; Region: Transgly; pfam00912
266834004558	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
266834004559	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
266834004560	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
266834004561	nucleotide binding site [chemical binding]; other site
266834004562	NEF interaction site [polypeptide binding]; other site
266834004563	SBD interface [polypeptide binding]; other site
266834004564	chaperone protein DnaJ; Provisional; Region: PRK10767
266834004565	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
266834004566	HSP70 interaction site [polypeptide binding]; other site
266834004567	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
266834004568	substrate binding site [polypeptide binding]; other site
266834004569	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
266834004570	Zn binding sites [ion binding]; other site
266834004571	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
266834004572	dimer interface [polypeptide binding]; other site
266834004573	Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486
266834004574	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
266834004575	Uncharacterized conserved protein [Function unknown]; Region: COG5588
266834004576	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
266834004577	Protein of unknown function DUF47; Region: PhoU_div; pfam01865
266834004578	recombination protein F; Reviewed; Region: recF; PRK00064
266834004579	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
266834004580	Walker A/P-loop; other site
266834004581	ATP binding site [chemical binding]; other site
266834004582	Q-loop/lid; other site
266834004583	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834004584	ABC transporter signature motif; other site
266834004585	Walker B; other site
266834004586	D-loop; other site
266834004587	H-loop/switch region; other site
266834004588	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
266834004589	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
266834004590	ATP binding site [chemical binding]; other site
266834004591	substrate interface [chemical binding]; other site
266834004592	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834004593	Coenzyme A binding pocket [chemical binding]; other site
266834004594	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834004595	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
266834004596	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
266834004597	Protein export membrane protein; Region: SecD_SecF; cl14618
266834004598	Protein export membrane protein; Region: SecD_SecF; cl14618
266834004599	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
266834004600	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834004601	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834004602	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834004603	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834004604	Walker A/P-loop; other site
266834004605	ATP binding site [chemical binding]; other site
266834004606	Q-loop/lid; other site
266834004607	ABC transporter signature motif; other site
266834004608	Walker B; other site
266834004609	D-loop; other site
266834004610	H-loop/switch region; other site
266834004611	TOBE domain; Region: TOBE_2; pfam08402
266834004612	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834004613	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834004614	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834004615	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834004616	dimer interface [polypeptide binding]; other site
266834004617	conserved gate region; other site
266834004618	putative PBP binding loops; other site
266834004619	ABC-ATPase subunit interface; other site
266834004620	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834004621	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834004622	dimer interface [polypeptide binding]; other site
266834004623	conserved gate region; other site
266834004624	putative PBP binding loops; other site
266834004625	ABC-ATPase subunit interface; other site
266834004626	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834004627	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834004628	Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103
266834004629	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
266834004630	putative active site [active]
266834004631	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
266834004632	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
266834004633	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834004634	DNA-binding site [nucleotide binding]; DNA binding site
266834004635	UTRA domain; Region: UTRA; pfam07702
266834004636	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
266834004637	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
266834004638	dimer interface [polypeptide binding]; other site
266834004639	active site
266834004640	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
266834004641	dimer interface [polypeptide binding]; other site
266834004642	active site
266834004643	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
266834004644	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
266834004645	active site
266834004646	dimer interface [polypeptide binding]; other site
266834004647	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
266834004648	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
266834004649	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
266834004650	hypothetical protein; Provisional; Region: PRK06102
266834004651	Amidase; Region: Amidase; cl11426
266834004652	CysZ-like protein; Reviewed; Region: PRK12768
266834004653	hypothetical protein; Provisional; Region: PRK00736
266834004654	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
266834004655	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
266834004656	ligand binding site [chemical binding]; other site
266834004657	methionine sulfoxide reductase A; Provisional; Region: PRK00058
266834004658	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
266834004659	HicB family; Region: HicB; pfam05534
266834004660	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
266834004661	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834004662	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834004663	muropeptide transporter; Validated; Region: ampG; cl17669
266834004664	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
266834004665	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
266834004666	N-terminal plug; other site
266834004667	ligand-binding site [chemical binding]; other site
266834004668	hypothetical protein; Provisional; Region: PRK07588
266834004669	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
266834004670	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834004671	putative substrate translocation pore; other site
266834004672	Major Facilitator Superfamily; Region: MFS_1; pfam07690
266834004673	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834004674	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834004675	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834004676	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
266834004677	putative substrate binding pocket [chemical binding]; other site
266834004678	putative dimerization interface [polypeptide binding]; other site
266834004679	Predicted permeases [General function prediction only]; Region: COG0679
266834004680	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
266834004681	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
266834004682	homodimer interface [polypeptide binding]; other site
266834004683	substrate-cofactor binding pocket; other site
266834004684	catalytic residue [active]
266834004685	Cytochrome c2 [Energy production and conversion]; Region: COG3474
266834004686	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
266834004687	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
266834004688	Ligand binding site; other site
266834004689	oligomer interface; other site
266834004690	prephenate dehydratase; Provisional; Region: PRK11899
266834004691	Prephenate dehydratase; Region: PDT; pfam00800
266834004692	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
266834004693	putative L-Phe binding site [chemical binding]; other site
266834004694	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
266834004695	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
266834004696	putative dimer interface [polypeptide binding]; other site
266834004697	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834004698	Predicted transcriptional regulator [Transcription]; Region: COG2378
266834004699	HTH domain; Region: HTH_11; pfam08279
266834004700	WYL domain; Region: WYL; pfam13280
266834004701	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
266834004702	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
266834004703	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
266834004704	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
266834004705	putative NADH binding site [chemical binding]; other site
266834004706	putative active site [active]
266834004707	nudix motif; other site
266834004708	putative metal binding site [ion binding]; other site
266834004709	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
266834004710	nucleotide binding site/active site [active]
266834004711	HIT family signature motif; other site
266834004712	catalytic residue [active]
266834004713	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
266834004714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834004715	Walker A motif; other site
266834004716	ATP binding site [chemical binding]; other site
266834004717	Walker B motif; other site
266834004718	arginine finger; other site
266834004719	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
266834004720	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
266834004721	hypothetical protein; Validated; Region: PRK00153
266834004722	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
266834004723	recombination protein RecR; Reviewed; Region: recR; PRK00076
266834004724	RecR protein; Region: RecR; pfam02132
266834004725	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
266834004726	putative active site [active]
266834004727	putative metal-binding site [ion binding]; other site
266834004728	tetramer interface [polypeptide binding]; other site
266834004729	Transglycosylase SLT domain; Region: SLT_2; pfam13406
266834004730	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
266834004731	N-acetyl-D-glucosamine binding site [chemical binding]; other site
266834004732	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834004733	Transmembrane secretion effector; Region: MFS_3; pfam05977
266834004734	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834004735	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834004736	ribosome maturation protein RimP; Reviewed; Region: PRK00092
266834004737	Sm and related proteins; Region: Sm_like; cl00259
266834004738	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
266834004739	putative oligomer interface [polypeptide binding]; other site
266834004740	putative RNA binding site [nucleotide binding]; other site
266834004741	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
266834004742	NusA N-terminal domain; Region: NusA_N; pfam08529
266834004743	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
266834004744	RNA binding site [nucleotide binding]; other site
266834004745	homodimer interface [polypeptide binding]; other site
266834004746	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
266834004747	G-X-X-G motif; other site
266834004748	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
266834004749	G-X-X-G motif; other site
266834004750	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
266834004751	hypothetical protein; Provisional; Region: PRK09190
266834004752	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
266834004753	putative RNA binding cleft [nucleotide binding]; other site
266834004754	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
266834004755	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
266834004756	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
266834004757	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
266834004758	G1 box; other site
266834004759	putative GEF interaction site [polypeptide binding]; other site
266834004760	GTP/Mg2+ binding site [chemical binding]; other site
266834004761	Switch I region; other site
266834004762	G2 box; other site
266834004763	G3 box; other site
266834004764	Switch II region; other site
266834004765	G4 box; other site
266834004766	G5 box; other site
266834004767	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
266834004768	Translation-initiation factor 2; Region: IF-2; pfam11987
266834004769	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
266834004770	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
266834004771	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
266834004772	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
266834004773	RNA binding site [nucleotide binding]; other site
266834004774	active site
266834004775	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
266834004776	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
266834004777	HWE histidine kinase; Region: HWE_HK; pfam07536
266834004778	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
266834004779	16S/18S rRNA binding site [nucleotide binding]; other site
266834004780	S13e-L30e interaction site [polypeptide binding]; other site
266834004781	25S rRNA binding site [nucleotide binding]; other site
266834004782	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
266834004783	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
266834004784	RNase E interface [polypeptide binding]; other site
266834004785	trimer interface [polypeptide binding]; other site
266834004786	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
266834004787	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
266834004788	RNase E interface [polypeptide binding]; other site
266834004789	trimer interface [polypeptide binding]; other site
266834004790	active site
266834004791	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
266834004792	putative nucleic acid binding region [nucleotide binding]; other site
266834004793	G-X-X-G motif; other site
266834004794	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
266834004795	RNA binding site [nucleotide binding]; other site
266834004796	domain interface; other site
266834004797	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
266834004798	Methyltransferase small domain; Region: MTS; pfam05175
266834004799	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
266834004800	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
266834004801	NAD binding site [chemical binding]; other site
266834004802	homotetramer interface [polypeptide binding]; other site
266834004803	homodimer interface [polypeptide binding]; other site
266834004804	substrate binding site [chemical binding]; other site
266834004805	active site
266834004806	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
266834004807	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
266834004808	dimer interface [polypeptide binding]; other site
266834004809	active site
266834004810	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
266834004811	active site 1 [active]
266834004812	dimer interface [polypeptide binding]; other site
266834004813	active site 2 [active]
266834004814	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
266834004815	metal binding site 2 [ion binding]; metal-binding site
266834004816	putative DNA binding helix; other site
266834004817	metal binding site 1 [ion binding]; metal-binding site
266834004818	dimer interface [polypeptide binding]; other site
266834004819	Predicted membrane protein [Function unknown]; Region: COG2860
266834004820	UPF0126 domain; Region: UPF0126; pfam03458
266834004821	UPF0126 domain; Region: UPF0126; pfam03458
266834004822	Uncharacterized conserved protein [Function unknown]; Region: COG1434
266834004823	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
266834004824	putative active site [active]
266834004825	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
266834004826	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
266834004827	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
266834004828	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
266834004829	hinge; other site
266834004830	active site
266834004831	cytidylate kinase; Provisional; Region: cmk; PRK00023
266834004832	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
266834004833	CMP-binding site; other site
266834004834	The sites determining sugar specificity; other site
266834004835	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
266834004836	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
266834004837	RNA binding site [nucleotide binding]; other site
266834004838	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
266834004839	RNA binding site [nucleotide binding]; other site
266834004840	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
266834004841	RNA binding site [nucleotide binding]; other site
266834004842	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
266834004843	RNA binding site [nucleotide binding]; other site
266834004844	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
266834004845	RNA binding site [nucleotide binding]; other site
266834004846	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
266834004847	RNA binding site [nucleotide binding]; other site
266834004848	BA14K-like protein; Region: BA14K; pfam07886
266834004849	Cache domain; Region: Cache_1; pfam02743
266834004850	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
266834004851	dimerization interface [polypeptide binding]; other site
266834004852	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834004853	cyclase homology domain; Region: CHD; cd07302
266834004854	nucleotidyl binding site; other site
266834004855	metal binding site [ion binding]; metal-binding site
266834004856	dimer interface [polypeptide binding]; other site
266834004857	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
266834004858	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
266834004859	putative ligand binding site [chemical binding]; other site
266834004860	putative NAD binding site [chemical binding]; other site
266834004861	catalytic site [active]
266834004862	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
266834004863	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
266834004864	catalytic site [active]
266834004865	putative active site [active]
266834004866	putative substrate binding site [chemical binding]; other site
266834004867	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834004868	Winged helix-turn helix; Region: HTH_29; pfam13551
266834004869	Homeodomain-like domain; Region: HTH_32; pfam13565
266834004870	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
266834004871	Integrase core domain; Region: rve; pfam00665
266834004872	Integrase core domain; Region: rve_3; pfam13683
266834004873	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
266834004874	GIY-YIG motif/motif A; other site
266834004875	putative active site [active]
266834004876	putative metal binding site [ion binding]; other site
266834004877	Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526
266834004878	Predicted membrane protein [Function unknown]; Region: COG2259
266834004879	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
266834004880	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
266834004881	Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302
266834004882	GTP-binding protein LepA; Provisional; Region: PRK05433
266834004883	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
266834004884	G1 box; other site
266834004885	putative GEF interaction site [polypeptide binding]; other site
266834004886	GTP/Mg2+ binding site [chemical binding]; other site
266834004887	Switch I region; other site
266834004888	G2 box; other site
266834004889	G3 box; other site
266834004890	Switch II region; other site
266834004891	G4 box; other site
266834004892	G5 box; other site
266834004893	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
266834004894	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
266834004895	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
266834004896	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834004897	putative substrate translocation pore; other site
266834004898	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
266834004899	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834004900	sequence-specific DNA binding site [nucleotide binding]; other site
266834004901	salt bridge; other site
266834004902	Cupin domain; Region: Cupin_2; pfam07883
266834004903	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834004904	Coenzyme A binding pocket [chemical binding]; other site
266834004905	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
266834004906	putative outer membrane lipoprotein; Provisional; Region: PRK10510
266834004907	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
266834004908	ligand binding site [chemical binding]; other site
266834004909	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
266834004910	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
266834004911	FeS/SAM binding site; other site
266834004912	Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269
266834004913	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
266834004914	motif 1; other site
266834004915	dimer interface [polypeptide binding]; other site
266834004916	active site
266834004917	motif 2; other site
266834004918	motif 3; other site
266834004919	elongation factor P; Validated; Region: PRK00529
266834004920	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
266834004921	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
266834004922	RNA binding site [nucleotide binding]; other site
266834004923	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
266834004924	RNA binding site [nucleotide binding]; other site
266834004925	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
266834004926	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
266834004927	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834004928	S-adenosylmethionine binding site [chemical binding]; other site
266834004929	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
266834004930	diiron binding motif [ion binding]; other site
266834004931	Uncharacterized conserved protein [Function unknown]; Region: COG1633
266834004932	CCC1-related protein family; Region: CCC1_like_1; cd02437
266834004933	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
266834004934	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
266834004935	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
266834004936	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
266834004937	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
266834004938	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
266834004939	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
266834004940	23S rRNA binding site [nucleotide binding]; other site
266834004941	L21 binding site [polypeptide binding]; other site
266834004942	L13 binding site [polypeptide binding]; other site
266834004943	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
266834004944	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
266834004945	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
266834004946	dimer interface [polypeptide binding]; other site
266834004947	motif 1; other site
266834004948	active site
266834004949	motif 2; other site
266834004950	motif 3; other site
266834004951	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
266834004952	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
266834004953	putative tRNA-binding site [nucleotide binding]; other site
266834004954	B3/4 domain; Region: B3_4; pfam03483
266834004955	tRNA synthetase B5 domain; Region: B5; smart00874
266834004956	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
266834004957	dimer interface [polypeptide binding]; other site
266834004958	motif 1; other site
266834004959	motif 3; other site
266834004960	motif 2; other site
266834004961	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
266834004962	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
266834004963	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834004964	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834004965	active site
266834004966	catalytic tetrad [active]
266834004967	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
266834004968	catalytic tetrad [active]
266834004969	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834004970	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834004971	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
266834004972	putative effector binding pocket; other site
266834004973	putative dimerization interface [polypeptide binding]; other site
266834004974	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
266834004975	dimerization interface [polypeptide binding]; other site
266834004976	metal binding site [ion binding]; metal-binding site
266834004977	short chain dehydrogenase; Provisional; Region: PRK07478
266834004978	classical (c) SDRs; Region: SDR_c; cd05233
266834004979	NAD(P) binding site [chemical binding]; other site
266834004980	active site
266834004981	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834004982	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834004983	active site
266834004984	catalytic tetrad [active]
266834004985	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834004986	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834004987	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
266834004988	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
266834004989	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834004990	non-specific DNA binding site [nucleotide binding]; other site
266834004991	salt bridge; other site
266834004992	sequence-specific DNA binding site [nucleotide binding]; other site
266834004993	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
266834004994	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
266834004995	generic binding surface II; other site
266834004996	generic binding surface I; other site
266834004997	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
266834004998	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
266834004999	MarR family; Region: MarR_2; cl17246
266834005000	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
266834005001	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
266834005002	EamA-like transporter family; Region: EamA; pfam00892
266834005003	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
266834005004	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
266834005005	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834005006	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
266834005007	C-terminal domain interface [polypeptide binding]; other site
266834005008	GSH binding site (G-site) [chemical binding]; other site
266834005009	dimer interface [polypeptide binding]; other site
266834005010	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
266834005011	N-terminal domain interface [polypeptide binding]; other site
266834005012	dimer interface [polypeptide binding]; other site
266834005013	substrate binding pocket (H-site) [chemical binding]; other site
266834005014	Transcriptional regulators [Transcription]; Region: MarR; COG1846
266834005015	MarR family; Region: MarR_2; pfam12802
266834005016	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
266834005017	putative deacylase active site [active]
266834005018	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
266834005019	ArsC family; Region: ArsC; pfam03960
266834005020	putative catalytic residues [active]
266834005021	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
266834005022	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834005023	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834005024	homodimer interface [polypeptide binding]; other site
266834005025	catalytic residue [active]
266834005026	Predicted deacylase [General function prediction only]; Region: COG3608
266834005027	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
266834005028	active site
266834005029	Zn binding site [ion binding]; other site
266834005030	VirB8 protein; Region: VirB8; cl01500
266834005031	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
266834005032	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
266834005033	putative active site [active]
266834005034	GMP synthase; Reviewed; Region: guaA; PRK00074
266834005035	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
266834005036	AMP/PPi binding site [chemical binding]; other site
266834005037	candidate oxyanion hole; other site
266834005038	catalytic triad [active]
266834005039	potential glutamine specificity residues [chemical binding]; other site
266834005040	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
266834005041	ATP Binding subdomain [chemical binding]; other site
266834005042	Ligand Binding sites [chemical binding]; other site
266834005043	Dimerization subdomain; other site
266834005044	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705
266834005045	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026
266834005046	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
266834005047	CoenzymeA binding site [chemical binding]; other site
266834005048	subunit interaction site [polypeptide binding]; other site
266834005049	PHB binding site; other site
266834005050	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
266834005051	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834005052	Coenzyme A binding pocket [chemical binding]; other site
266834005053	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490
266834005054	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
266834005055	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
266834005056	Cl binding site [ion binding]; other site
266834005057	oligomer interface [polypeptide binding]; other site
266834005058	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG3489
266834005059	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
266834005060	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
266834005061	Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487
266834005062	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
266834005063	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834005064	S-adenosylmethionine binding site [chemical binding]; other site
266834005065	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
266834005066	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
266834005067	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834005068	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
266834005069	putative NAD(P) binding site [chemical binding]; other site
266834005070	epoxyqueuosine reductase; Region: TIGR00276
266834005071	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
266834005072	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834005073	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
266834005074	C-terminal domain interface [polypeptide binding]; other site
266834005075	GSH binding site (G-site) [chemical binding]; other site
266834005076	dimer interface [polypeptide binding]; other site
266834005077	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
266834005078	N-terminal domain interface [polypeptide binding]; other site
266834005079	dimer interface [polypeptide binding]; other site
266834005080	substrate binding pocket (H-site) [chemical binding]; other site
266834005081	Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968
266834005082	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
266834005083	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
266834005084	putative NAD(P) binding site [chemical binding]; other site
266834005085	active site
266834005086	Uncharacterized conserved protein [Function unknown]; Region: COG5470
266834005087	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
266834005088	active site
266834005089	dimer interface [polypeptide binding]; other site
266834005090	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
266834005091	catalytic core [active]
266834005092	Methyltransferase domain; Region: Methyltransf_31; pfam13847
266834005093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834005094	S-adenosylmethionine binding site [chemical binding]; other site
266834005095	DNA polymerase III subunit beta; Validated; Region: PRK05643
266834005096	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
266834005097	putative DNA binding surface [nucleotide binding]; other site
266834005098	dimer interface [polypeptide binding]; other site
266834005099	beta-clamp/clamp loader binding surface; other site
266834005100	beta-clamp/translesion DNA polymerase binding surface; other site
266834005101	Predicted methyltransferases [General function prediction only]; Region: COG0313
266834005102	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
266834005103	putative SAM binding site [chemical binding]; other site
266834005104	putative homodimer interface [polypeptide binding]; other site
266834005105	hypothetical protein; Reviewed; Region: PRK12497
266834005106	glutathione synthetase; Provisional; Region: PRK05246
266834005107	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
266834005108	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
266834005109	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
266834005110	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
266834005111	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834005112	Walker A motif; other site
266834005113	ATP binding site [chemical binding]; other site
266834005114	Walker B motif; other site
266834005115	arginine finger; other site
266834005116	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
266834005117	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
266834005118	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
266834005119	dimer interface [polypeptide binding]; other site
266834005120	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834005121	catalytic residue [active]
266834005122	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
266834005123	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
266834005124	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
266834005125	EamA-like transporter family; Region: EamA; pfam00892
266834005126	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834005127	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834005128	putative DNA binding site [nucleotide binding]; other site
266834005129	putative Zn2+ binding site [ion binding]; other site
266834005130	AsnC family; Region: AsnC_trans_reg; pfam01037
266834005131	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
266834005132	trimer interface [polypeptide binding]; other site
266834005133	active site
266834005134	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
266834005135	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
266834005136	G1 box; other site
266834005137	putative GEF interaction site [polypeptide binding]; other site
266834005138	GTP/Mg2+ binding site [chemical binding]; other site
266834005139	Switch I region; other site
266834005140	G2 box; other site
266834005141	G3 box; other site
266834005142	Switch II region; other site
266834005143	G4 box; other site
266834005144	G5 box; other site
266834005145	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
266834005146	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
266834005147	EamA-like transporter family; Region: EamA; pfam00892
266834005148	EamA-like transporter family; Region: EamA; pfam00892
266834005149	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
266834005150	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
266834005151	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834005152	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834005153	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834005154	NAD(P) binding site [chemical binding]; other site
266834005155	active site
266834005156	Uncharacterized conserved protein [Function unknown]; Region: COG3791
266834005157	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
266834005158	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
266834005159	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
266834005160	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
266834005161	dimer interface [polypeptide binding]; other site
266834005162	PYR/PP interface [polypeptide binding]; other site
266834005163	TPP binding site [chemical binding]; other site
266834005164	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
266834005165	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
266834005166	TPP-binding site [chemical binding]; other site
266834005167	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
266834005168	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
266834005169	substrate binding site [chemical binding]; other site
266834005170	ATP binding site [chemical binding]; other site
266834005171	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
266834005172	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
266834005173	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
266834005174	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
266834005175	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
266834005176	putative active site [active]
266834005177	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834005178	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834005179	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
266834005180	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
266834005181	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
266834005182	putative active site [active]
266834005183	putative dimer interface [polypeptide binding]; other site
266834005184	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
266834005185	Flavoprotein; Region: Flavoprotein; pfam02441
266834005186	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
266834005187	Predicted transcriptional regulator [Transcription]; Region: COG1959
266834005188	Transcriptional regulator; Region: Rrf2; pfam02082
266834005189	Transcriptional regulator; Region: Rrf2; cl17282
266834005190	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
266834005191	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
266834005192	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
266834005193	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
266834005194	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
266834005195	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834005196	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834005197	NAD(P) binding site [chemical binding]; other site
266834005198	active site
266834005199	ABC1 family; Region: ABC1; cl17513
266834005200	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
266834005201	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
266834005202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834005203	S-adenosylmethionine binding site [chemical binding]; other site
266834005204	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
266834005205	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
266834005206	DNA binding site [nucleotide binding]
266834005207	catalytic residue [active]
266834005208	H2TH interface [polypeptide binding]; other site
266834005209	putative catalytic residues [active]
266834005210	turnover-facilitating residue; other site
266834005211	intercalation triad [nucleotide binding]; other site
266834005212	8OG recognition residue [nucleotide binding]; other site
266834005213	putative reading head residues; other site
266834005214	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
266834005215	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
266834005216	enoyl-CoA hydratase; Provisional; Region: PRK05862
266834005217	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
266834005218	substrate binding site [chemical binding]; other site
266834005219	oxyanion hole (OAH) forming residues; other site
266834005220	trimer interface [polypeptide binding]; other site
266834005221	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
266834005222	DnaA N-terminal domain; Region: DnaA_N; pfam11638
266834005223	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
266834005224	Bacterial dnaA protein; Region: Bac_DnaA; pfam00308
266834005225	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
266834005226	DnaA box-binding interface [nucleotide binding]; other site
266834005227	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
266834005228	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
266834005229	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
266834005230	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
266834005231	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
266834005232	putative hydrophobic ligand binding site [chemical binding]; other site
266834005233	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
266834005234	SnoaL-like domain; Region: SnoaL_3; pfam13474
266834005235	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
266834005236	putative dimer interface [polypeptide binding]; other site
266834005237	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834005238	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
266834005239	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
266834005240	FeS/SAM binding site; other site
266834005241	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
266834005242	active site
266834005243	dimerization interface [polypeptide binding]; other site
266834005244	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
266834005245	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834005246	active site
266834005247	ribonuclease PH; Reviewed; Region: rph; PRK00173
266834005248	Ribonuclease PH; Region: RNase_PH_bact; cd11362
266834005249	hexamer interface [polypeptide binding]; other site
266834005250	active site
266834005251	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
266834005252	heat shock protein GrpE; Provisional; Region: PRK14141
266834005253	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
266834005254	dimer interface [polypeptide binding]; other site
266834005255	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
266834005256	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
266834005257	active site
266834005258	phosphorylation site [posttranslational modification]
266834005259	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
266834005260	30S subunit binding site; other site
266834005261	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
266834005262	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
266834005263	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
266834005264	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
266834005265	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
266834005266	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
266834005267	Walker A/P-loop; other site
266834005268	ATP binding site [chemical binding]; other site
266834005269	Q-loop/lid; other site
266834005270	ABC transporter signature motif; other site
266834005271	Walker B; other site
266834005272	D-loop; other site
266834005273	H-loop/switch region; other site
266834005274	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
266834005275	OstA-like protein; Region: OstA; pfam03968
266834005276	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
266834005277	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
266834005278	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
266834005279	tandem repeat interface [polypeptide binding]; other site
266834005280	oligomer interface [polypeptide binding]; other site
266834005281	active site residues [active]
266834005282	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
266834005283	IHF dimer interface [polypeptide binding]; other site
266834005284	IHF - DNA interface [nucleotide binding]; other site
266834005285	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
266834005286	putative hydrophobic ligand binding site [chemical binding]; other site
266834005287	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
266834005288	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834005289	S-adenosylmethionine binding site [chemical binding]; other site
266834005290	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
266834005291	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
266834005292	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
266834005293	lipoprotein signal peptidase; Provisional; Region: PRK14795
266834005294	PAS fold; Region: PAS_4; pfam08448
266834005295	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834005296	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834005297	dimer interface [polypeptide binding]; other site
266834005298	phosphorylation site [posttranslational modification]
266834005299	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834005300	ATP binding site [chemical binding]; other site
266834005301	Mg2+ binding site [ion binding]; other site
266834005302	G-X-G motif; other site
266834005303	Response regulator receiver domain; Region: Response_reg; pfam00072
266834005304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834005305	active site
266834005306	phosphorylation site [posttranslational modification]
266834005307	intermolecular recognition site; other site
266834005308	dimerization interface [polypeptide binding]; other site
266834005309	Putative hemolysin [General function prediction only]; Region: COG3176
266834005310	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
266834005311	Malic enzyme, N-terminal domain; Region: malic; pfam00390
266834005312	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
266834005313	putative NAD(P) binding site [chemical binding]; other site
266834005314	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
266834005315	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
266834005316	MutS domain I; Region: MutS_I; pfam01624
266834005317	MutS domain II; Region: MutS_II; pfam05188
266834005318	MutS domain III; Region: MutS_III; pfam05192
266834005319	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
266834005320	Walker A/P-loop; other site
266834005321	ATP binding site [chemical binding]; other site
266834005322	Q-loop/lid; other site
266834005323	ABC transporter signature motif; other site
266834005324	Walker B; other site
266834005325	D-loop; other site
266834005326	H-loop/switch region; other site
266834005327	PII uridylyl-transferase; Provisional; Region: PRK05092
266834005328	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
266834005329	metal binding triad; other site
266834005330	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
266834005331	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
266834005332	Zn2+ binding site [ion binding]; other site
266834005333	Mg2+ binding site [ion binding]; other site
266834005334	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
266834005335	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
266834005336	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
266834005337	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
266834005338	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834005339	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
266834005340	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
266834005341	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
266834005342	active site
266834005343	HIGH motif; other site
266834005344	dimer interface [polypeptide binding]; other site
266834005345	KMSKS motif; other site
266834005346	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
266834005347	Ligand Binding Site [chemical binding]; other site
266834005348	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
266834005349	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
266834005350	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
266834005351	Glycoprotease family; Region: Peptidase_M22; pfam00814
266834005352	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
266834005353	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834005354	Coenzyme A binding pocket [chemical binding]; other site
266834005355	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
266834005356	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
266834005357	putative acyl-acceptor binding pocket; other site
266834005358	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
266834005359	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
266834005360	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
266834005361	FeS/SAM binding site; other site
266834005362	TRAM domain; Region: TRAM; pfam01938
266834005363	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
266834005364	PhoH-like protein; Region: PhoH; pfam02562
266834005365	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
266834005366	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
266834005367	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
266834005368	Transporter associated domain; Region: CorC_HlyC; smart01091
266834005369	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
266834005370	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
266834005371	putative active site [active]
266834005372	catalytic triad [active]
266834005373	putative dimer interface [polypeptide binding]; other site
266834005374	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
266834005375	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834005376	non-specific DNA binding site [nucleotide binding]; other site
266834005377	salt bridge; other site
266834005378	sequence-specific DNA binding site [nucleotide binding]; other site
266834005379	S-adenosylmethionine synthetase; Validated; Region: PRK05250
266834005380	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
266834005381	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
266834005382	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
266834005383	Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220
266834005384	Uncharacterized small protein [Function unknown]; Region: COG5568
266834005385	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
266834005386	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
266834005387	putative dimer interface [polypeptide binding]; other site
266834005388	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
266834005389	active site
266834005390	tetramer interface [polypeptide binding]; other site
266834005391	Cache domain; Region: Cache_1; pfam02743
266834005392	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
266834005393	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
266834005394	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
266834005395	dimer interface [polypeptide binding]; other site
266834005396	putative CheW interface [polypeptide binding]; other site
266834005397	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
266834005398	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
266834005399	substrate binding site [chemical binding]; other site
266834005400	dimer interface [polypeptide binding]; other site
266834005401	ATP binding site [chemical binding]; other site
266834005402	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
266834005403	RmuC family; Region: RmuC; pfam02646
266834005404	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
266834005405	active site
266834005406	catalytic residues [active]
266834005407	metal binding site [ion binding]; metal-binding site
266834005408	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
266834005409	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
266834005410	putative active site [active]
266834005411	substrate binding site [chemical binding]; other site
266834005412	putative cosubstrate binding site; other site
266834005413	catalytic site [active]
266834005414	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
266834005415	substrate binding site [chemical binding]; other site
266834005416	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
266834005417	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
266834005418	dimerization interface 3.5A [polypeptide binding]; other site
266834005419	active site
266834005420	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
266834005421	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
266834005422	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
266834005423	Transposase; Region: DEDD_Tnp_IS110; pfam01548
266834005424	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
266834005425	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
266834005426	metal binding site [ion binding]; metal-binding site
266834005427	dimer interface [polypeptide binding]; other site
266834005428	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
266834005429	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
266834005430	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834005431	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834005432	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
266834005433	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834005434	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834005435	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
266834005436	putative effector binding pocket; other site
266834005437	putative dimerization interface [polypeptide binding]; other site
266834005438	Predicted transcriptional regulators [Transcription]; Region: COG1733
266834005439	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
266834005440	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
266834005441	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
266834005442	ATP binding site [chemical binding]; other site
266834005443	putative Mg++ binding site [ion binding]; other site
266834005444	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
266834005445	nucleotide binding region [chemical binding]; other site
266834005446	ATP-binding site [chemical binding]; other site
266834005447	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
266834005448	RNA binding site [nucleotide binding]; other site
266834005449	Predicted membrane protein [Function unknown]; Region: COG3152
266834005450	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
266834005451	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
266834005452	trimer interface [polypeptide binding]; other site
266834005453	active site
266834005454	substrate binding site [chemical binding]; other site
266834005455	CoA binding site [chemical binding]; other site
266834005456	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
266834005457	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
266834005458	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
266834005459	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
266834005460	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
266834005461	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
266834005462	DNA binding site [nucleotide binding]
266834005463	active site
266834005464	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
266834005465	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
266834005466	tetramer interface [polypeptide binding]; other site
266834005467	active site
266834005468	Mg2+/Mn2+ binding site [ion binding]; other site
266834005469	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
266834005470	homohexameric interface [polypeptide binding]; other site
266834005471	feedback inhibition sensing region; other site
266834005472	carbamate kinase; Reviewed; Region: PRK12686
266834005473	nucleotide binding site [chemical binding]; other site
266834005474	N-acetyl-L-glutamate binding site [chemical binding]; other site
266834005475	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
266834005476	Anti-sigma-K factor rskA; Region: RskA; pfam10099
266834005477	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
266834005478	SelR domain; Region: SelR; pfam01641
266834005479	Predicted membrane protein [Function unknown]; Region: COG4803
266834005480	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
266834005481	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
266834005482	G1 box; other site
266834005483	GTP/Mg2+ binding site [chemical binding]; other site
266834005484	Switch I region; other site
266834005485	G2 box; other site
266834005486	G3 box; other site
266834005487	Switch II region; other site
266834005488	G4 box; other site
266834005489	G5 box; other site
266834005490	membrane protein insertase; Provisional; Region: PRK01318
266834005491	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
266834005492	ribonuclease P; Reviewed; Region: rnpA; PRK01313
266834005493	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
266834005494	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
266834005495	dimerization interface [polypeptide binding]; other site
266834005496	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
266834005497	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
266834005498	dimer interface [polypeptide binding]; other site
266834005499	putative CheW interface [polypeptide binding]; other site
266834005500	Uncharacterized conserved protein [Function unknown]; Region: COG0398
266834005501	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
266834005502	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
266834005503	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
266834005504	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834005505	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
266834005506	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834005507	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834005508	ATP binding site [chemical binding]; other site
266834005509	Mg2+ binding site [ion binding]; other site
266834005510	G-X-G motif; other site
266834005511	tetracycline repressor protein TetR; Provisional; Region: PRK13756
266834005512	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834005513	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
266834005514	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
266834005515	homotrimer interaction site [polypeptide binding]; other site
266834005516	putative active site [active]
266834005517	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
266834005518	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
266834005519	phosphate binding site [ion binding]; other site
266834005520	Domain of unknown function DUF11; Region: DUF11; cl17728
266834005521	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
266834005522	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
266834005523	Domain of unknown function DUF11; Region: DUF11; cl17728
266834005524	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
266834005525	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
266834005526	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
266834005527	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
266834005528	trimer interface [polypeptide binding]; other site
266834005529	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
266834005530	trimer interface [polypeptide binding]; other site
266834005531	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
266834005532	trimer interface [polypeptide binding]; other site
266834005533	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
266834005534	trimer interface [polypeptide binding]; other site
266834005535	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
266834005536	trimer interface [polypeptide binding]; other site
266834005537	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
266834005538	Haemagglutinin; Region: HIM; pfam05662
266834005539	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
266834005540	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
266834005541	putative deacylase active site [active]
266834005542	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
266834005543	Uncharacterized conserved protein [Function unknown]; Region: COG5579
266834005544	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834005545	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834005546	active site
266834005547	catalytic tetrad [active]
266834005548	Uncharacterized conserved protein [Function unknown]; Region: COG1739
266834005549	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
266834005550	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
266834005551	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
266834005552	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
266834005553	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
266834005554	Glutamate binding site [chemical binding]; other site
266834005555	NAD binding site [chemical binding]; other site
266834005556	catalytic residues [active]
266834005557	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
266834005558	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
266834005559	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
266834005560	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
266834005561	active site
266834005562	metal binding site [ion binding]; metal-binding site
266834005563	hexamer interface [polypeptide binding]; other site
266834005564	FecR protein; Region: FecR; pfam04773
266834005565	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
266834005566	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
266834005567	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834005568	cyclase homology domain; Region: CHD; cd07302
266834005569	nucleotidyl binding site; other site
266834005570	metal binding site [ion binding]; metal-binding site
266834005571	dimer interface [polypeptide binding]; other site
266834005572	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
266834005573	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
266834005574	ligand binding site [chemical binding]; other site
266834005575	flexible hinge region; other site
266834005576	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
266834005577	putative switch regulator; other site
266834005578	non-specific DNA interactions [nucleotide binding]; other site
266834005579	DNA binding site [nucleotide binding]
266834005580	sequence specific DNA binding site [nucleotide binding]; other site
266834005581	putative cAMP binding site [chemical binding]; other site
266834005582	Predicted membrane protein [Function unknown]; Region: COG2259
266834005583	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
266834005584	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
266834005585	non-specific DNA interactions [nucleotide binding]; other site
266834005586	DNA binding site [nucleotide binding]
266834005587	sequence specific DNA binding site [nucleotide binding]; other site
266834005588	putative cAMP binding site [chemical binding]; other site
266834005589	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
266834005590	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
266834005591	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834005592	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
266834005593	ligand binding site [chemical binding]; other site
266834005594	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834005595	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834005596	TM-ABC transporter signature motif; other site
266834005597	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
266834005598	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834005599	Walker A/P-loop; other site
266834005600	ATP binding site [chemical binding]; other site
266834005601	Q-loop/lid; other site
266834005602	ABC transporter signature motif; other site
266834005603	Walker B; other site
266834005604	D-loop; other site
266834005605	H-loop/switch region; other site
266834005606	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
266834005607	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
266834005608	active site
266834005609	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
266834005610	active site
266834005611	substrate binding pocket [chemical binding]; other site
266834005612	dimer interface [polypeptide binding]; other site
266834005613	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
266834005614	active site
266834005615	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
266834005616	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
266834005617	putative substrate binding site [chemical binding]; other site
266834005618	putative ATP binding site [chemical binding]; other site
266834005619	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
266834005620	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
266834005621	active site
266834005622	dimer interface [polypeptide binding]; other site
266834005623	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
266834005624	dimer interface [polypeptide binding]; other site
266834005625	active site
266834005626	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
266834005627	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
266834005628	acyl-activating enzyme (AAE) consensus motif; other site
266834005629	putative AMP binding site [chemical binding]; other site
266834005630	putative active site [active]
266834005631	putative CoA binding site [chemical binding]; other site
266834005632	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
266834005633	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834005634	putative substrate translocation pore; other site
266834005635	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
266834005636	Domain of unknown function DUF20; Region: UPF0118; pfam01594
266834005637	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
266834005638	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
266834005639	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
266834005640	putative acyl-acceptor binding pocket; other site
266834005641	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
266834005642	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
266834005643	Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588
266834005644	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
266834005645	integrase; Provisional; Region: PRK09692
266834005646	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
266834005647	active site
266834005648	Int/Topo IB signature motif; other site
266834005649	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
266834005650	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
266834005651	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834005652	non-specific DNA binding site [nucleotide binding]; other site
266834005653	salt bridge; other site
266834005654	sequence-specific DNA binding site [nucleotide binding]; other site
266834005655	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
266834005656	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
266834005657	Protein of unknown function (DUF499); Region: DUF499; pfam04465
266834005658	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
266834005659	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
266834005660	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
266834005661	TIGR02646 family protein; Region: TIGR02646
266834005662	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
266834005663	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834005664	Walker A/P-loop; other site
266834005665	ATP binding site [chemical binding]; other site
266834005666	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834005667	Q-loop/lid; other site
266834005668	ABC transporter signature motif; other site
266834005669	Walker B; other site
266834005670	D-loop; other site
266834005671	H-loop/switch region; other site
266834005672	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
266834005673	ATP binding site [chemical binding]; other site
266834005674	putative Mg++ binding site [ion binding]; other site
266834005675	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
266834005676	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
266834005677	nucleotide binding region [chemical binding]; other site
266834005678	ATP-binding site [chemical binding]; other site
266834005679	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
266834005680	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
266834005681	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834005682	sequence-specific DNA binding site [nucleotide binding]; other site
266834005683	salt bridge; other site
266834005684	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
266834005685	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
266834005686	FMN binding site [chemical binding]; other site
266834005687	substrate binding site [chemical binding]; other site
266834005688	putative catalytic residue [active]
266834005689	Uncharacterized conserved protein [Function unknown]; Region: COG2326
266834005690	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
266834005691	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834005692	dimer interface [polypeptide binding]; other site
266834005693	phosphorylation site [posttranslational modification]
266834005694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834005695	ATP binding site [chemical binding]; other site
266834005696	Mg2+ binding site [ion binding]; other site
266834005697	G-X-G motif; other site
266834005698	PBP superfamily domain; Region: PBP_like_2; pfam12849
266834005699	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
266834005700	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
266834005701	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834005702	dimer interface [polypeptide binding]; other site
266834005703	conserved gate region; other site
266834005704	putative PBP binding loops; other site
266834005705	ABC-ATPase subunit interface; other site
266834005706	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
266834005707	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
266834005708	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834005709	dimer interface [polypeptide binding]; other site
266834005710	conserved gate region; other site
266834005711	putative PBP binding loops; other site
266834005712	ABC-ATPase subunit interface; other site
266834005713	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
266834005714	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
266834005715	Walker A/P-loop; other site
266834005716	ATP binding site [chemical binding]; other site
266834005717	Q-loop/lid; other site
266834005718	ABC transporter signature motif; other site
266834005719	Walker B; other site
266834005720	D-loop; other site
266834005721	H-loop/switch region; other site
266834005722	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
266834005723	PhoU domain; Region: PhoU; pfam01895
266834005724	PhoU domain; Region: PhoU; pfam01895
266834005725	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
266834005726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834005727	active site
266834005728	phosphorylation site [posttranslational modification]
266834005729	intermolecular recognition site; other site
266834005730	dimerization interface [polypeptide binding]; other site
266834005731	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834005732	DNA binding site [nucleotide binding]
266834005733	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352
266834005734	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
266834005735	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834005736	inhibitor-cofactor binding pocket; inhibition site
266834005737	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834005738	catalytic residue [active]
266834005739	ornithine carbamoyltransferase; Provisional; Region: PRK00779
266834005740	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
266834005741	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
266834005742	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
266834005743	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
266834005744	dimerization interface [polypeptide binding]; other site
266834005745	domain crossover interface; other site
266834005746	redox-dependent activation switch; other site
266834005747	Uncharacterized protein affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism]; Region: ApaG; COG2967
266834005748	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
266834005749	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
266834005750	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
266834005751	homodimer interface [polypeptide binding]; other site
266834005752	substrate-cofactor binding pocket; other site
266834005753	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834005754	catalytic residue [active]
266834005755	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
266834005756	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
266834005757	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
266834005758	trimer interface [polypeptide binding]; other site
266834005759	active site
266834005760	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
266834005761	trimer interface [polypeptide binding]; other site
266834005762	active site
266834005763	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
266834005764	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834005765	substrate binding pocket [chemical binding]; other site
266834005766	membrane-bound complex binding site; other site
266834005767	hinge residues; other site
266834005768	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
266834005769	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
266834005770	tellurite resistance protein terB; Region: terB; cd07176
266834005771	putative metal binding site [ion binding]; other site
266834005772	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
266834005773	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
266834005774	Predicted transcriptional regulator [Transcription]; Region: COG2932
266834005775	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
266834005776	Catalytic site [active]
266834005777	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
266834005778	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
266834005779	Predicted transcriptional regulators [Transcription]; Region: COG1733
266834005780	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
266834005781	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900
266834005782	putative hydrophobic ligand binding site [chemical binding]; other site
266834005783	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
266834005784	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
266834005785	substrate binding site [chemical binding]; other site
266834005786	oxyanion hole (OAH) forming residues; other site
266834005787	trimer interface [polypeptide binding]; other site
266834005788	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
266834005789	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
266834005790	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
266834005791	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
266834005792	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
266834005793	dimer interface [polypeptide binding]; other site
266834005794	active site
266834005795	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
266834005796	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
266834005797	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
266834005798	FAD binding site [chemical binding]; other site
266834005799	substrate binding site [chemical binding]; other site
266834005800	catalytic residues [active]
266834005801	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
266834005802	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
266834005803	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
266834005804	Sel1-like repeats; Region: SEL1; smart00671
266834005805	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
266834005806	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834005807	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
266834005808	conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186
266834005809	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834005810	AsnC family; Region: AsnC_trans_reg; pfam01037
266834005811	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
266834005812	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
266834005813	putative active site [active]
266834005814	putative metal binding site [ion binding]; other site
266834005815	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
266834005816	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
266834005817	ATP binding site [chemical binding]; other site
266834005818	putative Mg++ binding site [ion binding]; other site
266834005819	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
266834005820	nucleotide binding region [chemical binding]; other site
266834005821	ATP-binding site [chemical binding]; other site
266834005822	DEAD/H associated; Region: DEAD_assoc; pfam08494
266834005823	Predicted transcriptional regulator [Transcription]; Region: COG1959
266834005824	Transcriptional regulator; Region: Rrf2; pfam02082
266834005825	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
266834005826	Uncharacterized conserved protein [Function unknown]; Region: COG2128
266834005827	Uncharacterized conserved protein [Function unknown]; Region: COG1284
266834005828	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
266834005829	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
266834005830	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
266834005831	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834005832	S-adenosylmethionine binding site [chemical binding]; other site
266834005833	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
266834005834	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
266834005835	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
266834005836	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
266834005837	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
266834005838	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
266834005839	quinone interaction residues [chemical binding]; other site
266834005840	active site
266834005841	catalytic residues [active]
266834005842	FMN binding site [chemical binding]; other site
266834005843	substrate binding site [chemical binding]; other site
266834005844	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
266834005845	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
266834005846	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834005847	active site
266834005848	phosphorylation site [posttranslational modification]
266834005849	intermolecular recognition site; other site
266834005850	dimerization interface [polypeptide binding]; other site
266834005851	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834005852	DNA binding residues [nucleotide binding]
266834005853	dimerization interface [polypeptide binding]; other site
266834005854	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
266834005855	Na binding site [ion binding]; other site
266834005856	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834005857	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834005858	dimer interface [polypeptide binding]; other site
266834005859	phosphorylation site [posttranslational modification]
266834005860	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834005861	ATP binding site [chemical binding]; other site
266834005862	Mg2+ binding site [ion binding]; other site
266834005863	G-X-G motif; other site
266834005864	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
266834005865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834005866	active site
266834005867	phosphorylation site [posttranslational modification]
266834005868	intermolecular recognition site; other site
266834005869	dimerization interface [polypeptide binding]; other site
266834005870	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
266834005871	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
266834005872	aspartate aminotransferase; Provisional; Region: PRK06108
266834005873	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834005874	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834005875	homodimer interface [polypeptide binding]; other site
266834005876	catalytic residue [active]
266834005877	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
266834005878	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
266834005879	NAD binding site [chemical binding]; other site
266834005880	homodimer interface [polypeptide binding]; other site
266834005881	active site
266834005882	substrate binding site [chemical binding]; other site
266834005883	chorismate mutase related enzymes; Region: CM-like; TIGR01803
266834005884	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
266834005885	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
266834005886	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
266834005887	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
266834005888	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
266834005889	metal binding site [ion binding]; metal-binding site
266834005890	putative dimer interface [polypeptide binding]; other site
266834005891	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834005892	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834005893	dimer interface [polypeptide binding]; other site
266834005894	conserved gate region; other site
266834005895	putative PBP binding loops; other site
266834005896	ABC-ATPase subunit interface; other site
266834005897	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834005898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834005899	dimer interface [polypeptide binding]; other site
266834005900	conserved gate region; other site
266834005901	putative PBP binding loops; other site
266834005902	ABC-ATPase subunit interface; other site
266834005903	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834005904	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
266834005905	substrate binding pocket [chemical binding]; other site
266834005906	membrane-bound complex binding site; other site
266834005907	hinge residues; other site
266834005908	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
266834005909	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834005910	Walker A/P-loop; other site
266834005911	ATP binding site [chemical binding]; other site
266834005912	Q-loop/lid; other site
266834005913	ABC transporter signature motif; other site
266834005914	Walker B; other site
266834005915	D-loop; other site
266834005916	H-loop/switch region; other site
266834005917	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
266834005918	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834005919	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
266834005920	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
266834005921	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834005922	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834005923	homodimer interface [polypeptide binding]; other site
266834005924	catalytic residue [active]
266834005925	hypothetical protein; Provisional; Region: PRK07524
266834005926	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
266834005927	PYR/PP interface [polypeptide binding]; other site
266834005928	dimer interface [polypeptide binding]; other site
266834005929	TPP binding site [chemical binding]; other site
266834005930	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
266834005931	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
266834005932	TPP-binding site [chemical binding]; other site
266834005933	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
266834005934	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
266834005935	Protein export membrane protein; Region: SecD_SecF; pfam02355
266834005936	Rrf2 family protein; Region: rrf2_super; TIGR00738
266834005937	Transcriptional regulator; Region: Rrf2; pfam02082
266834005938	KpsF/GutQ family protein; Region: kpsF; TIGR00393
266834005939	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
266834005940	putative active site [active]
266834005941	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
266834005942	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
266834005943	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
266834005944	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
266834005945	Sulfatase; Region: Sulfatase; cl17466
266834005946	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
266834005947	3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939
266834005948	putative NAD(P) binding site [chemical binding]; other site
266834005949	homotetramer interface [polypeptide binding]; other site
266834005950	active site
266834005951	homodimer interface [polypeptide binding]; other site
266834005952	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
266834005953	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
266834005954	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
266834005955	catalytic residue [active]
266834005956	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
266834005957	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
266834005958	active site
266834005959	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
266834005960	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
266834005961	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
266834005962	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
266834005963	Enoylreductase; Region: PKS_ER; smart00829
266834005964	NAD(P) binding site [chemical binding]; other site
266834005965	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
266834005966	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
266834005967	putative NADP binding site [chemical binding]; other site
266834005968	active site
266834005969	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
266834005970	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
266834005971	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
266834005972	SLBB domain; Region: SLBB; pfam10531
266834005973	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
266834005974	Isochorismatase family; Region: Isochorismatase; pfam00857
266834005975	catalytic triad [active]
266834005976	metal binding site [ion binding]; metal-binding site
266834005977	conserved cis-peptide bond; other site
266834005978	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
266834005979	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
266834005980	active site
266834005981	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
266834005982	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
266834005983	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
266834005984	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
266834005985	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
266834005986	Uncharacterized conserved protein [Function unknown]; Region: COG5569
266834005987	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834005988	cyclase homology domain; Region: CHD; cd07302
266834005989	nucleotidyl binding site; other site
266834005990	metal binding site [ion binding]; metal-binding site
266834005991	dimer interface [polypeptide binding]; other site
266834005992	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
266834005993	RNA/DNA hybrid binding site [nucleotide binding]; other site
266834005994	active site
266834005995	multiple promoter invertase; Provisional; Region: mpi; PRK13413
266834005996	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
266834005997	catalytic residues [active]
266834005998	catalytic nucleophile [active]
266834005999	Presynaptic Site I dimer interface [polypeptide binding]; other site
266834006000	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
266834006001	Synaptic Flat tetramer interface [polypeptide binding]; other site
266834006002	Synaptic Site I dimer interface [polypeptide binding]; other site
266834006003	DNA binding site [nucleotide binding]
266834006004	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
266834006005	DDE superfamily endonuclease; Region: DDE_3; pfam13358
266834006006	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
266834006007	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
266834006008	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
266834006009	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834006010	Homeodomain-like domain; Region: HTH_32; pfam13565
266834006011	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
266834006012	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
266834006013	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
266834006014	ATP binding site [chemical binding]; other site
266834006015	putative Mg++ binding site [ion binding]; other site
266834006016	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
266834006017	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
266834006018	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
266834006019	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
266834006020	HsdM N-terminal domain; Region: HsdM_N; pfam12161
266834006021	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834006022	S-adenosylmethionine binding site [chemical binding]; other site
266834006023	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
266834006024	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
266834006025	Int/Topo IB signature motif; other site
266834006026	Transposase; Region: HTH_Tnp_1; cl17663
266834006027	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834006028	HTH-like domain; Region: HTH_21; pfam13276
266834006029	Integrase core domain; Region: rve; pfam00665
266834006030	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
266834006031	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
266834006032	catalytic residues [active]
266834006033	catalytic nucleophile [active]
266834006034	Recombinase; Region: Recombinase; pfam07508
266834006035	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
266834006036	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834006037	Winged helix-turn helix; Region: HTH_29; pfam13551
266834006038	Integrase core domain; Region: rve_3; pfam13683
266834006039	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
266834006040	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
266834006041	hinge; other site
266834006042	active site
266834006043	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
266834006044	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
266834006045	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
266834006046	NAD binding site [chemical binding]; other site
266834006047	dimerization interface [polypeptide binding]; other site
266834006048	product binding site; other site
266834006049	substrate binding site [chemical binding]; other site
266834006050	zinc binding site [ion binding]; other site
266834006051	catalytic residues [active]
266834006052	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5328
266834006053	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
266834006054	Low molecular weight phosphatase family; Region: LMWPc; cd00115
266834006055	active site
266834006056	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
266834006057	rRNA binding site [nucleotide binding]; other site
266834006058	predicted 30S ribosome binding site; other site
266834006059	Maf-like protein; Region: Maf; pfam02545
266834006060	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
266834006061	active site
266834006062	dimer interface [polypeptide binding]; other site
266834006063	zinc-binding protein; Provisional; Region: PRK01343
266834006064	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
266834006065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514
266834006066	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
266834006067	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
266834006068	active site
266834006069	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
266834006070	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
266834006071	putative deacylase active site [active]
266834006072	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952
266834006073	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
266834006074	short chain dehydrogenase; Validated; Region: PRK08324
266834006075	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
266834006076	active site
266834006077	Zn2+ binding site [ion binding]; other site
266834006078	intersubunit interface [polypeptide binding]; other site
266834006079	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
266834006080	putative NAD(P) binding site [chemical binding]; other site
266834006081	active site
266834006082	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
266834006083	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
266834006084	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
266834006085	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
266834006086	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
266834006087	ligand binding site [chemical binding]; other site
266834006088	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834006089	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834006090	Walker A/P-loop; other site
266834006091	ATP binding site [chemical binding]; other site
266834006092	Q-loop/lid; other site
266834006093	ABC transporter signature motif; other site
266834006094	Walker B; other site
266834006095	D-loop; other site
266834006096	H-loop/switch region; other site
266834006097	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834006098	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834006099	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834006100	TM-ABC transporter signature motif; other site
266834006101	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834006102	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834006103	TM-ABC transporter signature motif; other site
266834006104	Uncharacterized conserved protein [Function unknown]; Region: COG3254
266834006105	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
266834006106	Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772
266834006107	N- and C-terminal domain interface [polypeptide binding]; other site
266834006108	putative active site [active]
266834006109	putative MgATP binding site [chemical binding]; other site
266834006110	putative catalytic site [active]
266834006111	metal binding site [ion binding]; metal-binding site
266834006112	putative carbohydrate binding site [chemical binding]; other site
266834006113	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
266834006114	heme-binding site [chemical binding]; other site
266834006115	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
266834006116	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
266834006117	dimer interface [polypeptide binding]; other site
266834006118	putative CheW interface [polypeptide binding]; other site
266834006119	STAS domain; Region: STAS_2; pfam13466
266834006120	Response regulator receiver domain; Region: Response_reg; pfam00072
266834006121	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834006122	active site
266834006123	phosphorylation site [posttranslational modification]
266834006124	intermolecular recognition site; other site
266834006125	dimerization interface [polypeptide binding]; other site
266834006126	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
266834006127	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
266834006128	putative binding surface; other site
266834006129	active site
266834006130	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
266834006131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834006132	ATP binding site [chemical binding]; other site
266834006133	Mg2+ binding site [ion binding]; other site
266834006134	G-X-G motif; other site
266834006135	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
266834006136	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
266834006137	putative CheA interaction surface; other site
266834006138	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
266834006139	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
266834006140	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
266834006141	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
266834006142	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834006143	active site
266834006144	phosphorylation site [posttranslational modification]
266834006145	intermolecular recognition site; other site
266834006146	dimerization interface [polypeptide binding]; other site
266834006147	CheB methylesterase; Region: CheB_methylest; pfam01339
266834006148	Response regulator receiver domain; Region: Response_reg; pfam00072
266834006149	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834006150	active site
266834006151	phosphorylation site [posttranslational modification]
266834006152	intermolecular recognition site; other site
266834006153	dimerization interface [polypeptide binding]; other site
266834006154	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13497
266834006155	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
266834006156	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
266834006157	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
266834006158	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834006159	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
266834006160	dimerization interface [polypeptide binding]; other site
266834006161	DNA binding residues [nucleotide binding]
266834006162	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
266834006163	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834006164	DNA binding residues [nucleotide binding]
266834006165	dimerization interface [polypeptide binding]; other site
266834006166	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
266834006167	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
266834006168	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
266834006169	FliG C-terminal domain; Region: FliG_C; pfam01706
266834006170	flagellar motor switch protein FliN; Region: fliN; TIGR02480
266834006171	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
266834006172	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
266834006173	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
266834006174	flagellar motor protein MotA; Validated; Region: PRK09110
266834006175	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
266834006176	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
266834006177	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
266834006178	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
266834006179	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
266834006180	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
266834006181	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
266834006182	Walker A motif; other site
266834006183	ATP binding site [chemical binding]; other site
266834006184	Walker B motif; other site
266834006185	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
266834006186	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
266834006187	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
266834006188	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
266834006189	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
266834006190	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
266834006191	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
266834006192	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
266834006193	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
266834006194	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
266834006195	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
266834006196	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
266834006197	Uncharacterized conserved protein [Function unknown]; Region: COG3334
266834006198	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
266834006199	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
266834006200	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
266834006201	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
266834006202	Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344
266834006203	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
266834006204	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
266834006205	Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344
266834006206	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
266834006207	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
266834006208	Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344
266834006209	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
266834006210	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
266834006211	flagellin; Reviewed; Region: PRK12687
266834006212	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
266834006213	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
266834006214	flagellar motor protein MotB; Validated; Region: motB; PRK05996
266834006215	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
266834006216	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
266834006217	ligand binding site [chemical binding]; other site
266834006218	chemotaxis protein; Reviewed; Region: PRK12798
266834006219	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
266834006220	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
266834006221	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
266834006222	N-acetyl-D-glucosamine binding site [chemical binding]; other site
266834006223	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834006224	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834006225	DNA binding site [nucleotide binding]
266834006226	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
266834006227	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
266834006228	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
266834006229	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
266834006230	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
266834006231	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
266834006232	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
266834006233	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
266834006234	Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442
266834006235	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
266834006236	Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443
266834006237	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
266834006238	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
266834006239	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
266834006240	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
266834006241	FHIPEP family; Region: FHIPEP; pfam00771
266834006242	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
266834006243	Rod binding protein; Region: Rod-binding; pfam10135
266834006244	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
266834006245	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
266834006246	active site
266834006247	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
266834006248	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
266834006249	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
266834006250	homodimer interface [polypeptide binding]; other site
266834006251	NADP binding site [chemical binding]; other site
266834006252	substrate binding site [chemical binding]; other site
266834006253	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834006254	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834006255	DNA binding site [nucleotide binding]
266834006256	domain linker motif; other site
266834006257	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
266834006258	ligand binding site [chemical binding]; other site
266834006259	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834006260	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834006261	dimer interface [polypeptide binding]; other site
266834006262	conserved gate region; other site
266834006263	putative PBP binding loops; other site
266834006264	ABC-ATPase subunit interface; other site
266834006265	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834006266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834006267	dimer interface [polypeptide binding]; other site
266834006268	conserved gate region; other site
266834006269	putative PBP binding loops; other site
266834006270	ABC-ATPase subunit interface; other site
266834006271	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
266834006272	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
266834006273	active site
266834006274	catalytic site [active]
266834006275	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834006276	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834006277	Walker A/P-loop; other site
266834006278	ATP binding site [chemical binding]; other site
266834006279	Q-loop/lid; other site
266834006280	ABC transporter signature motif; other site
266834006281	Walker B; other site
266834006282	D-loop; other site
266834006283	H-loop/switch region; other site
266834006284	TOBE domain; Region: TOBE_2; pfam08402
266834006285	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
266834006286	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
266834006287	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
266834006288	6-phosphogluconate dehydratase; Region: edd; TIGR01196
266834006289	phosphogluconate dehydratase; Validated; Region: PRK09054
266834006290	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
266834006291	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
266834006292	putative active site [active]
266834006293	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
266834006294	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
266834006295	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
266834006296	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
266834006297	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834006298	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
266834006299	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
266834006300	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
266834006301	Predicted flavoproteins [General function prediction only]; Region: COG2081
266834006302	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834006303	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
266834006304	dimerization interface [polypeptide binding]; other site
266834006305	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
266834006306	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
266834006307	dimer interface [polypeptide binding]; other site
266834006308	putative CheW interface [polypeptide binding]; other site
266834006309	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834006310	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834006311	isocitrate lyase; Provisional; Region: PRK15063
266834006312	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
266834006313	tetramer interface [polypeptide binding]; other site
266834006314	active site
266834006315	Mg2+/Mn2+ binding site [ion binding]; other site
266834006316	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
266834006317	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834006318	non-specific DNA binding site [nucleotide binding]; other site
266834006319	salt bridge; other site
266834006320	sequence-specific DNA binding site [nucleotide binding]; other site
266834006321	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
266834006322	Domain of unknown function (DUF955); Region: DUF955; pfam06114
266834006323	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
266834006324	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
266834006325	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
266834006326	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
266834006327	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
266834006328	Walker A/P-loop; other site
266834006329	ATP binding site [chemical binding]; other site
266834006330	Q-loop/lid; other site
266834006331	ABC transporter signature motif; other site
266834006332	Walker B; other site
266834006333	D-loop; other site
266834006334	H-loop/switch region; other site
266834006335	TOBE domain; Region: TOBE_2; pfam08402
266834006336	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834006337	dimer interface [polypeptide binding]; other site
266834006338	conserved gate region; other site
266834006339	putative PBP binding loops; other site
266834006340	ABC-ATPase subunit interface; other site
266834006341	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834006342	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834006343	dimer interface [polypeptide binding]; other site
266834006344	conserved gate region; other site
266834006345	putative PBP binding loops; other site
266834006346	ABC-ATPase subunit interface; other site
266834006347	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
266834006348	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
266834006349	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
266834006350	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
266834006351	acyl-activating enzyme (AAE) consensus motif; other site
266834006352	putative AMP binding site [chemical binding]; other site
266834006353	putative active site [active]
266834006354	putative CoA binding site [chemical binding]; other site
266834006355	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
266834006356	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834006357	dimer interface [polypeptide binding]; other site
266834006358	conserved gate region; other site
266834006359	putative PBP binding loops; other site
266834006360	ABC-ATPase subunit interface; other site
266834006361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834006362	dimer interface [polypeptide binding]; other site
266834006363	conserved gate region; other site
266834006364	putative PBP binding loops; other site
266834006365	ABC-ATPase subunit interface; other site
266834006366	PAS domain S-box; Region: sensory_box; TIGR00229
266834006367	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834006368	putative active site [active]
266834006369	heme pocket [chemical binding]; other site
266834006370	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834006371	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834006372	dimer interface [polypeptide binding]; other site
266834006373	phosphorylation site [posttranslational modification]
266834006374	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834006375	ATP binding site [chemical binding]; other site
266834006376	Mg2+ binding site [ion binding]; other site
266834006377	G-X-G motif; other site
266834006378	Uncharacterized conserved protein [Function unknown]; Region: COG5490
266834006379	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
266834006380	classical (c) SDRs; Region: SDR_c; cd05233
266834006381	NAD(P) binding site [chemical binding]; other site
266834006382	active site
266834006383	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
266834006384	FAD binding domain; Region: FAD_binding_4; pfam01565
266834006385	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
266834006386	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834006387	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834006388	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834006389	dimerization interface [polypeptide binding]; other site
266834006390	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
266834006391	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
266834006392	tetrameric interface [polypeptide binding]; other site
266834006393	NAD binding site [chemical binding]; other site
266834006394	catalytic residues [active]
266834006395	Predicted membrane protein [Function unknown]; Region: COG4269
266834006396	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
266834006397	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
266834006398	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
266834006399	iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920
266834006400	Rrf2 family protein; Region: rrf2_super; TIGR00738
266834006401	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834006402	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
266834006403	peptide binding site [polypeptide binding]; other site
266834006404	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834006405	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834006406	dimer interface [polypeptide binding]; other site
266834006407	conserved gate region; other site
266834006408	putative PBP binding loops; other site
266834006409	ABC-ATPase subunit interface; other site
266834006410	dipeptide transporter; Provisional; Region: PRK10913
266834006411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834006412	dimer interface [polypeptide binding]; other site
266834006413	conserved gate region; other site
266834006414	putative PBP binding loops; other site
266834006415	ABC-ATPase subunit interface; other site
266834006416	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834006417	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
266834006418	Walker A/P-loop; other site
266834006419	ATP binding site [chemical binding]; other site
266834006420	Q-loop/lid; other site
266834006421	ABC transporter signature motif; other site
266834006422	Walker B; other site
266834006423	D-loop; other site
266834006424	H-loop/switch region; other site
266834006425	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834006426	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834006427	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
266834006428	Walker A/P-loop; other site
266834006429	ATP binding site [chemical binding]; other site
266834006430	Q-loop/lid; other site
266834006431	ABC transporter signature motif; other site
266834006432	Walker B; other site
266834006433	D-loop; other site
266834006434	H-loop/switch region; other site
266834006435	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834006436	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
266834006437	homotrimer interaction site [polypeptide binding]; other site
266834006438	putative active site [active]
266834006439	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
266834006440	two-component response regulator; Provisional; Region: PRK09191
266834006441	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
266834006442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834006443	active site
266834006444	phosphorylation site [posttranslational modification]
266834006445	intermolecular recognition site; other site
266834006446	dimerization interface [polypeptide binding]; other site
266834006447	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834006448	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
266834006449	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834006450	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
266834006451	MgtC family; Region: MgtC; pfam02308
266834006452	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312
266834006453	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
266834006454	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
266834006455	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
266834006456	Chromate transporter; Region: Chromate_transp; pfam02417
266834006457	exopolyphosphatase; Region: exo_poly_only; TIGR03706
266834006458	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
266834006459	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
266834006460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834006461	S-adenosylmethionine binding site [chemical binding]; other site
266834006462	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
266834006463	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834006464	Major Facilitator Superfamily; Region: MFS_1; pfam07690
266834006465	putative substrate translocation pore; other site
266834006466	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
266834006467	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
266834006468	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
266834006469	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
266834006470	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
266834006471	active site
266834006472	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5331
266834006473	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
266834006474	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834006475	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
266834006476	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
266834006477	dimerization interface [polypeptide binding]; other site
266834006478	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
266834006479	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
266834006480	tetramer interface [polypeptide binding]; other site
266834006481	heme binding pocket [chemical binding]; other site
266834006482	NADPH binding site [chemical binding]; other site
266834006483	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
266834006484	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834006485	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834006486	dimerization interface [polypeptide binding]; other site
266834006487	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
266834006488	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834006489	non-specific DNA binding site [nucleotide binding]; other site
266834006490	salt bridge; other site
266834006491	sequence-specific DNA binding site [nucleotide binding]; other site
266834006492	Uncharacterized conserved protein [Function unknown]; Region: COG5403
266834006493	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
266834006494	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
266834006495	RNA methyltransferase, RsmE family; Region: TIGR00046
266834006496	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
266834006497	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
266834006498	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
266834006499	nudix motif; other site
266834006500	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834006501	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834006502	DNA-binding site [nucleotide binding]; DNA binding site
266834006503	FCD domain; Region: FCD; pfam07729
266834006504	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4949
266834006505	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834006506	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834006507	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834006508	putative effector binding pocket; other site
266834006509	dimerization interface [polypeptide binding]; other site
266834006510	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
266834006511	FAD binding domain; Region: FAD_binding_4; pfam01565
266834006512	FAD binding domain; Region: FAD_binding_4; pfam01565
266834006513	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
266834006514	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
266834006515	Cysteine-rich domain; Region: CCG; pfam02754
266834006516	Cysteine-rich domain; Region: CCG; pfam02754
266834006517	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
266834006518	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
266834006519	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
266834006520	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
266834006521	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
266834006522	Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953
266834006523	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
266834006524	Na binding site [ion binding]; other site
266834006525	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
266834006526	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
266834006527	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
266834006528	dimer interface [polypeptide binding]; other site
266834006529	motif 1; other site
266834006530	active site
266834006531	motif 2; other site
266834006532	motif 3; other site
266834006533	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
266834006534	anticodon binding site; other site
266834006535	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
266834006536	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
266834006537	motif 1; other site
266834006538	dimer interface [polypeptide binding]; other site
266834006539	active site
266834006540	motif 2; other site
266834006541	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
266834006542	motif 3; other site
266834006543	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
266834006544	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
266834006545	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
266834006546	C-terminal domain interface [polypeptide binding]; other site
266834006547	GSH binding site (G-site) [chemical binding]; other site
266834006548	dimer interface [polypeptide binding]; other site
266834006549	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
266834006550	dimer interface [polypeptide binding]; other site
266834006551	substrate binding pocket (H-site) [chemical binding]; other site
266834006552	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
266834006553	N-terminal domain interface [polypeptide binding]; other site
266834006554	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
266834006555	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
266834006556	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834006557	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
266834006558	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
266834006559	ring oligomerisation interface [polypeptide binding]; other site
266834006560	ATP/Mg binding site [chemical binding]; other site
266834006561	stacking interactions; other site
266834006562	hinge regions; other site
266834006563	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
266834006564	oligomerisation interface [polypeptide binding]; other site
266834006565	mobile loop; other site
266834006566	roof hairpin; other site
266834006567	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
266834006568	active site residue [active]
266834006569	Uncharacterized conserved protein [Function unknown]; Region: COG4275
266834006570	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
266834006571	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
266834006572	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
266834006573	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
266834006574	active site
266834006575	Riboflavin kinase; Region: Flavokinase; smart00904
266834006576	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
266834006577	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
266834006578	active site
266834006579	HIGH motif; other site
266834006580	nucleotide binding site [chemical binding]; other site
266834006581	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
266834006582	active site
266834006583	KMSKS motif; other site
266834006584	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
266834006585	tRNA binding surface [nucleotide binding]; other site
266834006586	anticodon binding site; other site
266834006587	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
266834006588	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834006589	Coenzyme A binding pocket [chemical binding]; other site
266834006590	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
266834006591	nucleoside/Zn binding site; other site
266834006592	dimer interface [polypeptide binding]; other site
266834006593	catalytic motif [active]
266834006594	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
266834006595	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
266834006596	RNA binding surface [nucleotide binding]; other site
266834006597	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
266834006598	active site
266834006599	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
266834006600	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834006601	S-adenosylmethionine binding site [chemical binding]; other site
266834006602	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
266834006603	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
266834006604	nucleophile elbow; other site
266834006605	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
266834006606	putative active site [active]
266834006607	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
266834006608	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
266834006609	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
266834006610	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
266834006611	TrkA-N domain; Region: TrkA_N; pfam02254
266834006612	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
266834006613	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
266834006614	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
266834006615	active site
266834006616	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
266834006617	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
266834006618	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
266834006619	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
266834006620	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
266834006621	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834006622	motif II; other site
266834006623	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
266834006624	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
266834006625	DDE superfamily endonuclease; Region: DDE_3; pfam13358
266834006626	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
266834006627	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
266834006628	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834006629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
266834006630	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
266834006631	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834006632	ATP binding site [chemical binding]; other site
266834006633	Mg2+ binding site [ion binding]; other site
266834006634	G-X-G motif; other site
266834006635	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
266834006636	ATP binding site [chemical binding]; other site
266834006637	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
266834006638	PAS fold; Region: PAS_4; pfam08448
266834006639	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834006640	putative active site [active]
266834006641	heme pocket [chemical binding]; other site
266834006642	Response regulator receiver domain; Region: Response_reg; pfam00072
266834006643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834006644	active site
266834006645	phosphorylation site [posttranslational modification]
266834006646	intermolecular recognition site; other site
266834006647	dimerization interface [polypeptide binding]; other site
266834006648	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834006649	metal binding site [ion binding]; metal-binding site
266834006650	active site
266834006651	I-site; other site
266834006652	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834006653	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
266834006654	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834006655	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
266834006656	dimerization interface [polypeptide binding]; other site
266834006657	substrate binding pocket [chemical binding]; other site
266834006658	Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253
266834006659	PRC-barrel domain; Region: PRC; pfam05239
266834006660	dihydroxy-acid dehydratase; Validated; Region: PRK06131
266834006661	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
266834006662	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
266834006663	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
266834006664	active site
266834006665	intersubunit interface [polypeptide binding]; other site
266834006666	catalytic residue [active]
266834006667	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
266834006668	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
266834006669	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834006670	classical (c) SDRs; Region: SDR_c; cd05233
266834006671	NAD(P) binding site [chemical binding]; other site
266834006672	active site
266834006673	Transcriptional regulator [Transcription]; Region: IclR; COG1414
266834006674	Bacterial transcriptional regulator; Region: IclR; pfam01614
266834006675	transcriptional regulator TraR; Provisional; Region: PRK13870
266834006676	Autoinducer binding domain; Region: Autoind_bind; pfam03472
266834006677	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834006678	DNA binding residues [nucleotide binding]
266834006679	dimerization interface [polypeptide binding]; other site
266834006680	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
266834006681	Autoinducer binding domain; Region: Autoind_bind; pfam03472
266834006682	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834006683	DNA binding residues [nucleotide binding]
266834006684	dimerization interface [polypeptide binding]; other site
266834006685	Domain of unknown function DUF59; Region: DUF59; pfam01883
266834006686	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
266834006687	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
266834006688	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
266834006689	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
266834006690	Cl binding site [ion binding]; other site
266834006691	oligomer interface [polypeptide binding]; other site
266834006692	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
266834006693	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
266834006694	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
266834006695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
266834006696	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
266834006697	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
266834006698	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
266834006699	F0F1 ATP synthase subunit B'; Validated; Region: PRK09174
266834006700	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
266834006701	F0F1 ATP synthase subunit B; Validated; Region: PRK09173
266834006702	F0F1 ATP synthase subunit B; Provisional; Region: PRK14475
266834006703	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
266834006704	RNA/DNA hybrid binding site [nucleotide binding]; other site
266834006705	active site
266834006706	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
266834006707	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
266834006708	FeS/SAM binding site; other site
266834006709	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
266834006710	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
266834006711	active site
266834006712	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
266834006713	MPT binding site; other site
266834006714	trimer interface [polypeptide binding]; other site
266834006715	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
266834006716	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
266834006717	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
266834006718	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834006719	TPR motif; other site
266834006720	binding surface
266834006721	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834006722	binding surface
266834006723	TPR motif; other site
266834006724	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834006725	binding surface
266834006726	TPR motif; other site
266834006727	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
266834006728	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
266834006729	substrate binding pocket [chemical binding]; other site
266834006730	chain length determination region; other site
266834006731	substrate-Mg2+ binding site; other site
266834006732	catalytic residues [active]
266834006733	aspartate-rich region 1; other site
266834006734	active site lid residues [active]
266834006735	aspartate-rich region 2; other site
266834006736	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
266834006737	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
266834006738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834006739	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
266834006740	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
266834006741	tandem repeat interface [polypeptide binding]; other site
266834006742	oligomer interface [polypeptide binding]; other site
266834006743	active site residues [active]
266834006744	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
266834006745	dimer interface [polypeptide binding]; other site
266834006746	motif 1; other site
266834006747	active site
266834006748	motif 2; other site
266834006749	motif 3; other site
266834006750	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
266834006751	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
266834006752	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
266834006753	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
266834006754	Uncharacterized conserved protein [Function unknown]; Region: COG1683
266834006755	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
266834006756	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
266834006757	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
266834006758	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
266834006759	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
266834006760	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834006761	metal binding site [ion binding]; metal-binding site
266834006762	active site
266834006763	I-site; other site
266834006764	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834006765	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
266834006766	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
266834006767	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834006768	Major Facilitator Superfamily; Region: MFS_1; pfam07690
266834006769	putative substrate translocation pore; other site
266834006770	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
266834006771	Helix-turn-helix domain; Region: HTH_18; pfam12833
266834006772	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
266834006773	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
266834006774	UbiA prenyltransferase family; Region: UbiA; pfam01040
266834006775	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
266834006776	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
266834006777	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
266834006778	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
266834006779	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
266834006780	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
266834006781	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
266834006782	FAD binding domain; Region: FAD_binding_4; pfam01565
266834006783	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
266834006784	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
266834006785	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
266834006786	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
266834006787	[2Fe-2S] cluster binding site [ion binding]; other site
266834006788	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
266834006789	putative alpha subunit interface [polypeptide binding]; other site
266834006790	putative active site [active]
266834006791	putative substrate binding site [chemical binding]; other site
266834006792	Fe binding site [ion binding]; other site
266834006793	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
266834006794	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
266834006795	FAD binding pocket [chemical binding]; other site
266834006796	FAD binding motif [chemical binding]; other site
266834006797	phosphate binding motif [ion binding]; other site
266834006798	beta-alpha-beta structure motif; other site
266834006799	NAD binding pocket [chemical binding]; other site
266834006800	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834006801	catalytic loop [active]
266834006802	iron binding site [ion binding]; other site
266834006803	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
266834006804	active site
266834006805	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
266834006806	BA14K-like protein; Region: BA14K; pfam07886
266834006807	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
266834006808	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
266834006809	Cl binding site [ion binding]; other site
266834006810	oligomer interface [polypeptide binding]; other site
266834006811	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
266834006812	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
266834006813	active site
266834006814	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
266834006815	enoyl-CoA hydratase; Provisional; Region: PRK06688
266834006816	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
266834006817	substrate binding site [chemical binding]; other site
266834006818	oxyanion hole (OAH) forming residues; other site
266834006819	trimer interface [polypeptide binding]; other site
266834006820	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
266834006821	Cache domain; Region: Cache_1; pfam02743
266834006822	HAMP domain; Region: HAMP; pfam00672
266834006823	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
266834006824	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
266834006825	dimer interface [polypeptide binding]; other site
266834006826	putative CheW interface [polypeptide binding]; other site
266834006827	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
266834006828	TRAM domain; Region: TRAM; cl01282
266834006829	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834006830	S-adenosylmethionine binding site [chemical binding]; other site
266834006831	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
266834006832	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
266834006833	RNA binding surface [nucleotide binding]; other site
266834006834	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
266834006835	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
266834006836	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
266834006837	TPP-binding site; other site
266834006838	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
266834006839	PYR/PP interface [polypeptide binding]; other site
266834006840	dimer interface [polypeptide binding]; other site
266834006841	TPP binding site [chemical binding]; other site
266834006842	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
266834006843	Pirin-related protein [General function prediction only]; Region: COG1741
266834006844	Pirin; Region: Pirin; pfam02678
266834006845	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
266834006846	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
266834006847	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
266834006848	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
266834006849	putative active site [active]
266834006850	Zn binding site [ion binding]; other site
266834006851	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
266834006852	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
266834006853	NADP binding site [chemical binding]; other site
266834006854	dimer interface [polypeptide binding]; other site
266834006855	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
266834006856	active site
266834006857	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
266834006858	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
266834006859	dimer interface [polypeptide binding]; other site
266834006860	active site
266834006861	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
266834006862	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
266834006863	acyl-activating enzyme (AAE) consensus motif; other site
266834006864	AMP binding site [chemical binding]; other site
266834006865	active site
266834006866	CoA binding site [chemical binding]; other site
266834006867	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
266834006868	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
266834006869	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
266834006870	Walker A/P-loop; other site
266834006871	ATP binding site [chemical binding]; other site
266834006872	Q-loop/lid; other site
266834006873	ABC transporter signature motif; other site
266834006874	Walker B; other site
266834006875	D-loop; other site
266834006876	H-loop/switch region; other site
266834006877	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
266834006878	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
266834006879	protease TldD; Provisional; Region: tldD; PRK10735
266834006880	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
266834006881	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
266834006882	Sporulation related domain; Region: SPOR; pfam05036
266834006883	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
266834006884	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
266834006885	putative active site [active]
266834006886	putative metal binding site [ion binding]; other site
266834006887	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
266834006888	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
266834006889	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
266834006890	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
266834006891	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
266834006892	HSP70 interaction site [polypeptide binding]; other site
266834006893	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
266834006894	substrate binding site [polypeptide binding]; other site
266834006895	dimer interface [polypeptide binding]; other site
266834006896	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
266834006897	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
266834006898	NAD binding site [chemical binding]; other site
266834006899	homotetramer interface [polypeptide binding]; other site
266834006900	homodimer interface [polypeptide binding]; other site
266834006901	substrate binding site [chemical binding]; other site
266834006902	active site
266834006903	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
266834006904	catalytic core [active]
266834006905	Protein of unknown function (DUF1344); Region: DUF1344; pfam07076
266834006906	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
266834006907	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
266834006908	Tetramer interface [polypeptide binding]; other site
266834006909	active site
266834006910	FMN-binding site [chemical binding]; other site
266834006911	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
266834006912	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
266834006913	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
266834006914	dimerization interface [polypeptide binding]; other site
266834006915	active site
266834006916	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
266834006917	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00051
266834006918	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
266834006919	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
266834006920	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
266834006921	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
266834006922	Subunit I/III interface [polypeptide binding]; other site
266834006923	D-pathway; other site
266834006924	Subunit I/VIIc interface [polypeptide binding]; other site
266834006925	Subunit I/IV interface [polypeptide binding]; other site
266834006926	Subunit I/II interface [polypeptide binding]; other site
266834006927	Low-spin heme (heme a) binding site [chemical binding]; other site
266834006928	Subunit I/VIIa interface [polypeptide binding]; other site
266834006929	Subunit I/VIa interface [polypeptide binding]; other site
266834006930	Dimer interface; other site
266834006931	Putative water exit pathway; other site
266834006932	Binuclear center (heme a3/CuB) [ion binding]; other site
266834006933	K-pathway; other site
266834006934	Subunit I/Vb interface [polypeptide binding]; other site
266834006935	Putative proton exit pathway; other site
266834006936	Subunit I/VIb interface; other site
266834006937	Subunit I/VIc interface [polypeptide binding]; other site
266834006938	Electron transfer pathway; other site
266834006939	Subunit I/VIIIb interface [polypeptide binding]; other site
266834006940	Subunit I/VIIb interface [polypeptide binding]; other site
266834006941	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
266834006942	UbiA prenyltransferase family; Region: UbiA; pfam01040
266834006943	Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175
266834006944	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
266834006945	Subunit III/VIIa interface [polypeptide binding]; other site
266834006946	Phospholipid binding site [chemical binding]; other site
266834006947	Subunit I/III interface [polypeptide binding]; other site
266834006948	Subunit III/VIb interface [polypeptide binding]; other site
266834006949	Subunit III/VIa interface; other site
266834006950	Subunit III/Vb interface [polypeptide binding]; other site
266834006951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
266834006952	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
266834006953	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
266834006954	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
266834006955	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
266834006956	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
266834006957	putative active site [active]
266834006958	putative substrate binding site [chemical binding]; other site
266834006959	ATP binding site [chemical binding]; other site
266834006960	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
266834006961	RNA/DNA hybrid binding site [nucleotide binding]; other site
266834006962	active site
266834006963	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
266834006964	catalytic triad [active]
266834006965	dimer interface [polypeptide binding]; other site
266834006966	Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
266834006967	hypothetical protein; Validated; Region: PRK00228
266834006968	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
266834006969	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
266834006970	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834006971	PAS fold; Region: PAS_3; pfam08447
266834006972	putative active site [active]
266834006973	heme pocket [chemical binding]; other site
266834006974	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
266834006975	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834006976	metal binding site [ion binding]; metal-binding site
266834006977	active site
266834006978	I-site; other site
266834006979	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834006980	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
266834006981	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
266834006982	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
266834006983	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
266834006984	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
266834006985	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
266834006986	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
266834006987	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834006988	catalytic residue [active]
266834006989	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
266834006990	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
266834006991	dimerization interface [polypeptide binding]; other site
266834006992	ligand binding site [chemical binding]; other site
266834006993	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
266834006994	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834006995	motif II; other site
266834006996	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834006997	dimerization interface [polypeptide binding]; other site
266834006998	putative DNA binding site [nucleotide binding]; other site
266834006999	putative Zn2+ binding site [ion binding]; other site
266834007000	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
266834007001	DNA methylase; Region: N6_N4_Mtase; pfam01555
266834007002	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
266834007003	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
266834007004	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
266834007005	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
266834007006	minor groove reading motif; other site
266834007007	helix-hairpin-helix signature motif; other site
266834007008	substrate binding pocket [chemical binding]; other site
266834007009	active site
266834007010	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
266834007011	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
266834007012	DNA binding and oxoG recognition site [nucleotide binding]
266834007013	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389
266834007014	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
266834007015	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
266834007016	catalytic residues [active]
266834007017	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
266834007018	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
266834007019	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
266834007020	Walker A/P-loop; other site
266834007021	ATP binding site [chemical binding]; other site
266834007022	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
266834007023	ABC transporter signature motif; other site
266834007024	Walker B; other site
266834007025	D-loop; other site
266834007026	H-loop/switch region; other site
266834007027	pyruvate phosphate dikinase; Provisional; Region: PRK09279
266834007028	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
266834007029	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
266834007030	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
266834007031	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
266834007032	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
266834007033	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
266834007034	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
266834007035	Mechanosensitive ion channel; Region: MS_channel; pfam00924
266834007036	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834007037	non-specific DNA binding site [nucleotide binding]; other site
266834007038	salt bridge; other site
266834007039	sequence-specific DNA binding site [nucleotide binding]; other site
266834007040	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
266834007041	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
266834007042	CysD dimerization site [polypeptide binding]; other site
266834007043	G1 box; other site
266834007044	putative GEF interaction site [polypeptide binding]; other site
266834007045	GTP/Mg2+ binding site [chemical binding]; other site
266834007046	Switch I region; other site
266834007047	G2 box; other site
266834007048	G3 box; other site
266834007049	Switch II region; other site
266834007050	G4 box; other site
266834007051	G5 box; other site
266834007052	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
266834007053	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
266834007054	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
266834007055	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
266834007056	Active Sites [active]
266834007057	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
266834007058	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
266834007059	Active Sites [active]
266834007060	choline dehydrogenase; Validated; Region: PRK02106
266834007061	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
266834007062	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
266834007063	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
266834007064	NAD(P) binding site [chemical binding]; other site
266834007065	catalytic residues [active]
266834007066	Sulfatase; Region: Sulfatase; cl17466
266834007067	choline-sulfatase; Region: chol_sulfatase; TIGR03417
266834007068	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
266834007069	transcriptional regulator BetI; Validated; Region: PRK00767
266834007070	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834007071	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
266834007072	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
266834007073	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834007074	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
266834007075	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
266834007076	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834007077	metal binding site [ion binding]; metal-binding site
266834007078	active site
266834007079	I-site; other site
266834007080	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
266834007081	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
266834007082	NAD(P) binding site [chemical binding]; other site
266834007083	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
266834007084	L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448
266834007085	glutathionine S-transferase; Provisional; Region: PRK10542
266834007086	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
266834007087	C-terminal domain interface [polypeptide binding]; other site
266834007088	GSH binding site (G-site) [chemical binding]; other site
266834007089	dimer interface [polypeptide binding]; other site
266834007090	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
266834007091	dimer interface [polypeptide binding]; other site
266834007092	N-terminal domain interface [polypeptide binding]; other site
266834007093	substrate binding pocket (H-site) [chemical binding]; other site
266834007094	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
266834007095	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834007096	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
266834007097	dimerization interface [polypeptide binding]; other site
266834007098	substrate binding pocket [chemical binding]; other site
266834007099	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834007100	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
266834007101	putative C-terminal domain interface [polypeptide binding]; other site
266834007102	putative GSH binding site (G-site) [chemical binding]; other site
266834007103	putative dimer interface [polypeptide binding]; other site
266834007104	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
266834007105	dimer interface [polypeptide binding]; other site
266834007106	N-terminal domain interface [polypeptide binding]; other site
266834007107	putative substrate binding pocket (H-site) [chemical binding]; other site
266834007108	PAS fold; Region: PAS_4; pfam08448
266834007109	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
266834007110	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
266834007111	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
266834007112	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834007113	metal binding site [ion binding]; metal-binding site
266834007114	active site
266834007115	I-site; other site
266834007116	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834007117	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
266834007118	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
266834007119	Transcriptional regulators [Transcription]; Region: MarR; COG1846
266834007120	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834007121	putative Zn2+ binding site [ion binding]; other site
266834007122	putative DNA binding site [nucleotide binding]; other site
266834007123	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
266834007124	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
266834007125	PhnA protein; Region: PhnA; pfam03831
266834007126	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
266834007127	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
266834007128	Walker A motif; other site
266834007129	ATP binding site [chemical binding]; other site
266834007130	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834007131	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834007132	active site
266834007133	catalytic tetrad [active]
266834007134	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
266834007135	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834007136	S-adenosylmethionine binding site [chemical binding]; other site
266834007137	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
266834007138	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834007139	motif II; other site
266834007140	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
266834007141	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
266834007142	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260
266834007143	putative NAD(P) binding site [chemical binding]; other site
266834007144	catalytic Zn binding site [ion binding]; other site
266834007145	structural Zn binding site [ion binding]; other site
266834007146	aminotransferase; Provisional; Region: PRK13356
266834007147	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
266834007148	homodimer interface [polypeptide binding]; other site
266834007149	substrate-cofactor binding pocket; other site
266834007150	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834007151	catalytic residue [active]
266834007152	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
266834007153	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834007154	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
266834007155	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
266834007156	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
266834007157	Predicted transcriptional regulator [Transcription]; Region: COG2378
266834007158	HTH domain; Region: HTH_11; pfam08279
266834007159	WYL domain; Region: WYL; pfam13280
266834007160	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
266834007161	Cytochrome c556 [Energy production and conversion]; Region: COG3909
266834007162	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
266834007163	Cytochrome c; Region: Cytochrom_C; cl11414
266834007164	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
266834007165	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834007166	Coenzyme A binding pocket [chemical binding]; other site
266834007167	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
266834007168	DNA binding residues [nucleotide binding]
266834007169	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
266834007170	dimer interface [polypeptide binding]; other site
266834007171	putative metal binding site [ion binding]; other site
266834007172	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
266834007173	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
266834007174	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
266834007175	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
266834007176	Trp docking motif [polypeptide binding]; other site
266834007177	putative active site [active]
266834007178	Uncharacterized conserved protein [Function unknown]; Region: COG0397
266834007179	hypothetical protein; Validated; Region: PRK00029
266834007180	Protein of unknown function (DUF1697); Region: DUF1697; cl01557
266834007181	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
266834007182	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
266834007183	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
266834007184	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
266834007185	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
266834007186	putative metal binding site [ion binding]; other site
266834007187	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
266834007188	active site
266834007189	metal binding site [ion binding]; metal-binding site
266834007190	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
266834007191	Ligand Binding Site [chemical binding]; other site
266834007192	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
266834007193	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
266834007194	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
266834007195	methionine sulfoxide reductase B; Provisional; Region: PRK00222
266834007196	SelR domain; Region: SelR; pfam01641
266834007197	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
266834007198	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
266834007199	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
266834007200	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
266834007201	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
266834007202	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658
266834007203	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
266834007204	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
266834007205	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
266834007206	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
266834007207	Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320
266834007208	Predicted transcriptional regulator [Transcription]; Region: COG4957
266834007209	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
266834007210	two-component sensor protein; Provisional; Region: cpxA; PRK09470
266834007211	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834007212	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834007213	dimer interface [polypeptide binding]; other site
266834007214	phosphorylation site [posttranslational modification]
266834007215	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834007216	ATP binding site [chemical binding]; other site
266834007217	Mg2+ binding site [ion binding]; other site
266834007218	G-X-G motif; other site
266834007219	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
266834007220	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834007221	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834007222	Uncharacterized conserved protein [Function unknown]; Region: COG5447
266834007223	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
266834007224	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
266834007225	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
266834007226	Bacterial SH3 domain; Region: SH3_3; pfam08239
266834007227	Predicted integral membrane protein [Function unknown]; Region: COG5436
266834007228	Uncharacterized conserved protein [Function unknown]; Region: COG5402
266834007229	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
266834007230	Transglycosylase; Region: Transgly; pfam00912
266834007231	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
266834007232	hypothetical protein; Provisional; Region: PRK05170
266834007233	Protein of unknown function (DUF419); Region: DUF419; pfam04237
266834007234	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834007235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834007236	active site
266834007237	phosphorylation site [posttranslational modification]
266834007238	intermolecular recognition site; other site
266834007239	dimerization interface [polypeptide binding]; other site
266834007240	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834007241	DNA binding site [nucleotide binding]
266834007242	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834007243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834007244	ATP binding site [chemical binding]; other site
266834007245	Mg2+ binding site [ion binding]; other site
266834007246	G-X-G motif; other site
266834007247	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
266834007248	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
266834007249	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
266834007250	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834007251	binding surface
266834007252	TPR motif; other site
266834007253	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
266834007254	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
266834007255	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
266834007256	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
266834007257	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
266834007258	protein binding site [polypeptide binding]; other site
266834007259	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
266834007260	protein binding site [polypeptide binding]; other site
266834007261	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834007262	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834007263	active site
266834007264	phosphorylation site [posttranslational modification]
266834007265	intermolecular recognition site; other site
266834007266	dimerization interface [polypeptide binding]; other site
266834007267	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834007268	DNA binding site [nucleotide binding]
266834007269	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834007270	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
266834007271	dimerization interface [polypeptide binding]; other site
266834007272	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834007273	dimer interface [polypeptide binding]; other site
266834007274	phosphorylation site [posttranslational modification]
266834007275	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834007276	ATP binding site [chemical binding]; other site
266834007277	Mg2+ binding site [ion binding]; other site
266834007278	G-X-G motif; other site
266834007279	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
266834007280	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
266834007281	metal binding triad; other site
266834007282	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
266834007283	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
266834007284	metal binding triad; other site
266834007285	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834007286	PAS fold; Region: PAS_3; pfam08447
266834007287	putative active site [active]
266834007288	heme pocket [chemical binding]; other site
266834007289	PAS fold; Region: PAS_7; pfam12860
266834007290	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834007291	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834007292	dimer interface [polypeptide binding]; other site
266834007293	phosphorylation site [posttranslational modification]
266834007294	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834007295	ATP binding site [chemical binding]; other site
266834007296	Mg2+ binding site [ion binding]; other site
266834007297	G-X-G motif; other site
266834007298	aminopeptidase N; Provisional; Region: pepN; PRK14015
266834007299	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
266834007300	active site
266834007301	Zn binding site [ion binding]; other site
266834007302	EamA-like transporter family; Region: EamA; pfam00892
266834007303	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
266834007304	EamA-like transporter family; Region: EamA; pfam00892
266834007305	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834007306	putative MFS family transporter protein; Provisional; Region: PRK03633
266834007307	putative substrate translocation pore; other site
266834007308	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
266834007309	Fe-S cluster binding site [ion binding]; other site
266834007310	active site
266834007311	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
266834007312	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
266834007313	nucleotide binding site [chemical binding]; other site
266834007314	putative NEF/HSP70 interaction site [polypeptide binding]; other site
266834007315	SBD interface [polypeptide binding]; other site
266834007316	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
266834007317	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834007318	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
266834007319	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
266834007320	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
266834007321	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
266834007322	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834007323	dimer interface [polypeptide binding]; other site
266834007324	conserved gate region; other site
266834007325	putative PBP binding loops; other site
266834007326	ABC-ATPase subunit interface; other site
266834007327	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
266834007328	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
266834007329	putative NAD(P) binding site [chemical binding]; other site
266834007330	dimer interface [polypeptide binding]; other site
266834007331	Predicted transcriptional regulators [Transcription]; Region: COG1733
266834007332	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
266834007333	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
266834007334	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
266834007335	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
266834007336	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
266834007337	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
266834007338	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
266834007339	Ligand binding site; other site
266834007340	Putative Catalytic site; other site
266834007341	DXD motif; other site
266834007342	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
266834007343	AMP nucleosidase; Provisional; Region: PRK08292
266834007344	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
266834007345	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
266834007346	Uncharacterized conserved protein [Function unknown]; Region: COG1742
266834007347	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
266834007348	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
266834007349	C-terminal domain interface [polypeptide binding]; other site
266834007350	GSH binding site (G-site) [chemical binding]; other site
266834007351	dimer interface [polypeptide binding]; other site
266834007352	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
266834007353	N-terminal domain interface [polypeptide binding]; other site
266834007354	putative dimer interface [polypeptide binding]; other site
266834007355	active site
266834007356	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731
266834007357	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
266834007358	histidinol-phosphate aminotransferase; Provisional; Region: PRK08153
266834007359	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834007360	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834007361	homodimer interface [polypeptide binding]; other site
266834007362	catalytic residue [active]
266834007363	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
266834007364	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834007365	sequence-specific DNA binding site [nucleotide binding]; other site
266834007366	salt bridge; other site
266834007367	Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549
266834007368	Porin subfamily; Region: Porin_2; pfam02530
266834007369	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
266834007370	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
266834007371	active site
266834007372	DNA binding site [nucleotide binding]
266834007373	Int/Topo IB signature motif; other site
266834007374	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
266834007375	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834007376	Homeodomain-like domain; Region: HTH_32; pfam13565
266834007377	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
266834007378	DDE superfamily endonuclease; Region: DDE_3; pfam13358
266834007379	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
266834007380	Porin subfamily; Region: Porin_2; pfam02530
266834007381	BA14K-like protein; Region: BA14K; pfam07886
266834007382	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
266834007383	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
266834007384	N-acetyl-D-glucosamine binding site [chemical binding]; other site
266834007385	catalytic residue [active]
266834007386	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
266834007387	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
266834007388	dimer interface [polypeptide binding]; other site
266834007389	active site
266834007390	catalytic residue [active]
266834007391	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
266834007392	SmpB-tmRNA interface; other site
266834007393	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
266834007394	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
266834007395	Autotransporter beta-domain; Region: Autotransporter; pfam03797
266834007396	EBNA-3C; Provisional; Region: PHA03377
266834007397	Uncharacterized conserved protein [Function unknown]; Region: COG1432
266834007398	LabA_like proteins; Region: LabA; cd10911
266834007399	putative metal binding site [ion binding]; other site
266834007400	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
266834007401	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
266834007402	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
266834007403	Zn2+ binding site [ion binding]; other site
266834007404	Mg2+ binding site [ion binding]; other site
266834007405	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
266834007406	synthetase active site [active]
266834007407	NTP binding site [chemical binding]; other site
266834007408	metal binding site [ion binding]; metal-binding site
266834007409	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
266834007410	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
266834007411	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
266834007412	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
266834007413	Protein of unknown function (DUF3563); Region: DUF3563; pfam12086
266834007414	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216
266834007415	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
266834007416	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
266834007417	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
266834007418	Catalytic site [active]
266834007419	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
266834007420	ribonuclease III; Reviewed; Region: PRK12371
266834007421	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
266834007422	dimerization interface [polypeptide binding]; other site
266834007423	active site
266834007424	metal binding site [ion binding]; metal-binding site
266834007425	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
266834007426	dsRNA binding site [nucleotide binding]; other site
266834007427	GTPase Era; Reviewed; Region: era; PRK00089
266834007428	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
266834007429	G1 box; other site
266834007430	GTP/Mg2+ binding site [chemical binding]; other site
266834007431	Switch I region; other site
266834007432	G2 box; other site
266834007433	Switch II region; other site
266834007434	G3 box; other site
266834007435	G4 box; other site
266834007436	G5 box; other site
266834007437	KH domain; Region: KH_2; pfam07650
266834007438	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
266834007439	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
266834007440	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
266834007441	ArsC family; Region: ArsC; pfam03960
266834007442	catalytic residues [active]
266834007443	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
266834007444	amphipathic channel; other site
266834007445	Asn-Pro-Ala signature motifs; other site
266834007446	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834007447	dimerization interface [polypeptide binding]; other site
266834007448	putative DNA binding site [nucleotide binding]; other site
266834007449	putative Zn2+ binding site [ion binding]; other site
266834007450	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial  homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613
266834007451	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
266834007452	putative active site [active]
266834007453	catalytic site [active]
266834007454	putative metal binding site [ion binding]; other site
266834007455	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
266834007456	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834007457	S-adenosylmethionine binding site [chemical binding]; other site
266834007458	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
266834007459	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
266834007460	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
266834007461	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
266834007462	RNA binding site [nucleotide binding]; other site
266834007463	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
266834007464	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
266834007465	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
266834007466	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
266834007467	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834007468	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
266834007469	putative NAD(P) binding site [chemical binding]; other site
266834007470	active site
266834007471	putative substrate binding site [chemical binding]; other site
266834007472	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834007473	dimerization interface [polypeptide binding]; other site
266834007474	putative DNA binding site [nucleotide binding]; other site
266834007475	putative Zn2+ binding site [ion binding]; other site
266834007476	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
266834007477	hydrophobic ligand binding site; other site
266834007478	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
266834007479	active site
266834007480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
266834007481	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
266834007482	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
266834007483	Recombination protein O N terminal; Region: RecO_N; pfam11967
266834007484	Recombination protein O C terminal; Region: RecO_C; pfam02565
266834007485	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
266834007486	Predicted membrane protein [Function unknown]; Region: COG5373
266834007487	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
266834007488	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
266834007489	Zn2+ binding site [ion binding]; other site
266834007490	Mg2+ binding site [ion binding]; other site
266834007491	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
266834007492	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
266834007493	MOSC domain; Region: MOSC; pfam03473
266834007494	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
266834007495	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834007496	putative substrate translocation pore; other site
266834007497	quinolinate synthetase; Provisional; Region: PRK09375
266834007498	L-aspartate oxidase; Provisional; Region: PRK07512
266834007499	L-aspartate oxidase; Provisional; Region: PRK06175
266834007500	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
266834007501	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
266834007502	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
266834007503	dimerization interface [polypeptide binding]; other site
266834007504	active site
266834007505	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
266834007506	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
266834007507	E-class dimer interface [polypeptide binding]; other site
266834007508	P-class dimer interface [polypeptide binding]; other site
266834007509	active site
266834007510	Cu2+ binding site [ion binding]; other site
266834007511	Zn2+ binding site [ion binding]; other site
266834007512	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
266834007513	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834007514	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834007515	Walker A/P-loop; other site
266834007516	ATP binding site [chemical binding]; other site
266834007517	Q-loop/lid; other site
266834007518	ABC transporter signature motif; other site
266834007519	Walker B; other site
266834007520	D-loop; other site
266834007521	H-loop/switch region; other site
266834007522	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
266834007523	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834007524	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834007525	ACP:hemolysin acyltransferase (hemolysin-activating protein) [Posttranslational modification, protein turnover, chaperones]; Region: HlyC; COG2994
266834007526	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
266834007527	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
266834007528	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
266834007529	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
266834007530	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
266834007531	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
266834007532	Predicted secreted protein [Function unknown]; Region: COG5451
266834007533	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
266834007534	nudix motif; other site
266834007535	Uncharacterized conserved protein [Function unknown]; Region: COG2135
266834007536	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
266834007537	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
266834007538	active site
266834007539	HIGH motif; other site
266834007540	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
266834007541	KMSKS motif; other site
266834007542	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
266834007543	Uncharacterized conserved protein [Function unknown]; Region: COG3791
266834007544	Uncharacterized conserved protein [Function unknown]; Region: COG3791
266834007545	Uncharacterized conserved protein [Function unknown]; Region: COG3791
266834007546	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
266834007547	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
266834007548	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
266834007549	active site
266834007550	catalytic residues [active]
266834007551	metal binding site [ion binding]; metal-binding site
266834007552	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
266834007553	Predicted permeases [General function prediction only]; Region: RarD; COG2962
266834007554	EamA-like transporter family; Region: EamA; cl17759
266834007555	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
266834007556	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
266834007557	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
266834007558	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
266834007559	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834007560	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
266834007561	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
266834007562	Walker A/P-loop; other site
266834007563	ATP binding site [chemical binding]; other site
266834007564	Q-loop/lid; other site
266834007565	ABC transporter signature motif; other site
266834007566	Walker B; other site
266834007567	D-loop; other site
266834007568	H-loop/switch region; other site
266834007569	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
266834007570	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
266834007571	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
266834007572	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
266834007573	classical (c) SDRs; Region: SDR_c; cd05233
266834007574	NAD(P) binding site [chemical binding]; other site
266834007575	active site
266834007576	amidophosphoribosyltransferase; Provisional; Region: PRK09123
266834007577	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
266834007578	active site
266834007579	tetramer interface [polypeptide binding]; other site
266834007580	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
266834007581	active site
266834007582	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
266834007583	Colicin V production protein; Region: Colicin_V; pfam02674
266834007584	DNA repair protein RadA; Provisional; Region: PRK11823
266834007585	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
266834007586	Walker A motif/ATP binding site; other site
266834007587	ATP binding site [chemical binding]; other site
266834007588	Walker B motif; other site
266834007589	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
266834007590	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
266834007591	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
266834007592	active site
266834007593	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
266834007594	dimer interface [polypeptide binding]; other site
266834007595	substrate binding site [chemical binding]; other site
266834007596	catalytic residues [active]
266834007597	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
266834007598	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
266834007599	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834007600	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834007601	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
266834007602	Predicted membrane protein [Function unknown]; Region: COG4541
266834007603	replicative DNA helicase; Provisional; Region: PRK09165
266834007604	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
266834007605	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
266834007606	Walker A motif; other site
266834007607	ATP binding site [chemical binding]; other site
266834007608	Walker B motif; other site
266834007609	DNA binding loops [nucleotide binding]
266834007610	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
266834007611	MarR family; Region: MarR_2; pfam12802
266834007612	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
266834007613	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834007614	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
266834007615	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834007616	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834007617	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
266834007618	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
266834007619	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
266834007620	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
266834007621	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
266834007622	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
266834007623	dimerization interface [polypeptide binding]; other site
266834007624	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834007625	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834007626	active site
266834007627	catalytic tetrad [active]
266834007628	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
266834007629	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
266834007630	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
266834007631	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
266834007632	NAD(P) binding site [chemical binding]; other site
266834007633	homotetramer interface [polypeptide binding]; other site
266834007634	homodimer interface [polypeptide binding]; other site
266834007635	active site
266834007636	acyl carrier protein; Provisional; Region: acpP; PRK00982
266834007637	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
266834007638	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
266834007639	dimer interface [polypeptide binding]; other site
266834007640	active site
266834007641	YceG-like family; Region: YceG; pfam02618
266834007642	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
266834007643	dimerization interface [polypeptide binding]; other site
266834007644	Uncharacterized stress-induced protein [Function unknown]; Region: COG1561
266834007645	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
266834007646	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
266834007647	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
266834007648	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
266834007649	catalytic site [active]
266834007650	G-X2-G-X-G-K; other site
266834007651	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
266834007652	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834007653	S-adenosylmethionine binding site [chemical binding]; other site
266834007654	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
266834007655	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
266834007656	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
266834007657	SurA N-terminal domain; Region: SurA_N; pfam09312
266834007658	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
266834007659	Organic solvent tolerance protein; Region: OstA_C; pfam04453
266834007660	Predicted permeases [General function prediction only]; Region: COG0795
266834007661	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
266834007662	Predicted permeases [General function prediction only]; Region: COG0795
266834007663	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
266834007664	multifunctional aminopeptidase A; Provisional; Region: PRK00913
266834007665	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
266834007666	interface (dimer of trimers) [polypeptide binding]; other site
266834007667	Substrate-binding/catalytic site; other site
266834007668	Zn-binding sites [ion binding]; other site
266834007669	DNA polymerase III subunit chi; Validated; Region: PRK05728
266834007670	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
266834007671	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
266834007672	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
266834007673	Transposase [DNA replication, recombination, and repair]; Region: COG5433
266834007674	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834007675	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834007676	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834007677	Coenzyme A binding pocket [chemical binding]; other site
266834007678	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
266834007679	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
266834007680	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
266834007681	ABC transporter; Region: ABC_tran_2; pfam12848
266834007682	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
266834007683	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
266834007684	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
266834007685	acyl-activating enzyme (AAE) consensus motif; other site
266834007686	AMP binding site [chemical binding]; other site
266834007687	active site
266834007688	CoA binding site [chemical binding]; other site
266834007689	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
266834007690	Acyltransferase family; Region: Acyl_transf_3; pfam01757
266834007691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
266834007692	DinB superfamily; Region: DinB_2; pfam12867
266834007693	GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038
266834007694	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834007695	putative C-terminal domain interface [polypeptide binding]; other site
266834007696	putative GSH binding site (G-site) [chemical binding]; other site
266834007697	putative dimer interface [polypeptide binding]; other site
266834007698	C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202
266834007699	putative N-terminal domain interface [polypeptide binding]; other site
266834007700	putative dimer interface [polypeptide binding]; other site
266834007701	putative substrate binding pocket (H-site) [chemical binding]; other site
266834007702	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
266834007703	active site
266834007704	multimer interface [polypeptide binding]; other site
266834007705	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
266834007706	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
266834007707	CGNR zinc finger; Region: zf-CGNR; pfam11706
266834007708	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
266834007709	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834007710	TM-ABC transporter signature motif; other site
266834007711	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
266834007712	MoaE homodimer interface [polypeptide binding]; other site
266834007713	MoaD interaction [polypeptide binding]; other site
266834007714	active site residues [active]
266834007715	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
266834007716	MoaE interaction surface [polypeptide binding]; other site
266834007717	MoeB interaction surface [polypeptide binding]; other site
266834007718	thiocarboxylated glycine; other site
266834007719	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
266834007720	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
266834007721	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
266834007722	GIY-YIG motif/motif A; other site
266834007723	active site
266834007724	catalytic site [active]
266834007725	putative DNA binding site [nucleotide binding]; other site
266834007726	metal binding site [ion binding]; metal-binding site
266834007727	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
266834007728	short chain dehydrogenase; Provisional; Region: PRK09134
266834007729	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
266834007730	NADP binding site [chemical binding]; other site
266834007731	substrate binding pocket [chemical binding]; other site
266834007732	active site
266834007733	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
266834007734	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834007735	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
266834007736	putative C-terminal domain interface [polypeptide binding]; other site
266834007737	putative GSH binding site (G-site) [chemical binding]; other site
266834007738	putative dimer interface [polypeptide binding]; other site
266834007739	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
266834007740	N-terminal domain interface [polypeptide binding]; other site
266834007741	dimer interface [polypeptide binding]; other site
266834007742	putative substrate binding pocket (H-site) [chemical binding]; other site
266834007743	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
266834007744	B1 nucleotide binding pocket [chemical binding]; other site
266834007745	B2 nucleotide binding pocket [chemical binding]; other site
266834007746	CAS motifs; other site
266834007747	active site
266834007748	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
266834007749	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
266834007750	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
266834007751	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
266834007752	putative [4Fe-4S] binding site [ion binding]; other site
266834007753	putative molybdopterin cofactor binding site [chemical binding]; other site
266834007754	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
266834007755	putative molybdopterin cofactor binding site; other site
266834007756	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
266834007757	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
266834007758	dimer interface [polypeptide binding]; other site
266834007759	ADP-ribose binding site [chemical binding]; other site
266834007760	active site
266834007761	nudix motif; other site
266834007762	metal binding site [ion binding]; metal-binding site
266834007763	Predicted integral membrane protein [Function unknown]; Region: COG0392
266834007764	Uncharacterized conserved protein [Function unknown]; Region: COG2898
266834007765	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
266834007766	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
266834007767	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
266834007768	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
266834007769	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
266834007770	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
266834007771	active site
266834007772	substrate binding site [chemical binding]; other site
266834007773	cosubstrate binding site; other site
266834007774	catalytic site [active]
266834007775	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
266834007776	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
266834007777	dimerization interface [polypeptide binding]; other site
266834007778	putative ATP binding site [chemical binding]; other site
266834007779	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
266834007780	Domain of unknown function DUF20; Region: UPF0118; pfam01594
266834007781	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
266834007782	hypothetical protein; Validated; Region: PRK09087
266834007783	polyphosphate kinase; Provisional; Region: PRK05443
266834007784	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
266834007785	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
266834007786	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
266834007787	putative domain interface [polypeptide binding]; other site
266834007788	putative active site [active]
266834007789	catalytic site [active]
266834007790	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
266834007791	putative domain interface [polypeptide binding]; other site
266834007792	putative active site [active]
266834007793	catalytic site [active]
266834007794	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
266834007795	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
266834007796	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
266834007797	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834007798	cyclase homology domain; Region: CHD; cd07302
266834007799	nucleotidyl binding site; other site
266834007800	metal binding site [ion binding]; metal-binding site
266834007801	dimer interface [polypeptide binding]; other site
266834007802	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
266834007803	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
266834007804	catalytic site [active]
266834007805	putative active site [active]
266834007806	putative substrate binding site [chemical binding]; other site
266834007807	HRDC domain; Region: HRDC; pfam00570
266834007808	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
266834007809	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
266834007810	Multicopper oxidase; Region: Cu-oxidase; pfam00394
266834007811	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
266834007812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834007813	putative substrate translocation pore; other site
266834007814	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
266834007815	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
266834007816	dimer interface [polypeptide binding]; other site
266834007817	anticodon binding site; other site
266834007818	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
266834007819	homodimer interface [polypeptide binding]; other site
266834007820	motif 1; other site
266834007821	active site
266834007822	motif 2; other site
266834007823	GAD domain; Region: GAD; pfam02938
266834007824	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
266834007825	active site
266834007826	motif 3; other site
266834007827	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
266834007828	active site
266834007829	catalytic residue [active]
266834007830	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
266834007831	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
266834007832	ring oligomerisation interface [polypeptide binding]; other site
266834007833	ATP/Mg binding site [chemical binding]; other site
266834007834	stacking interactions; other site
266834007835	hinge regions; other site
266834007836	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
266834007837	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
266834007838	CAP-like domain; other site
266834007839	active site
266834007840	primary dimer interface [polypeptide binding]; other site
266834007841	EamA-like transporter family; Region: EamA; cl17759
266834007842	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
266834007843	Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935
266834007844	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
266834007845	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
266834007846	Predicted membrane protein/domain [Function unknown]; Region: COG1714
266834007847	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
266834007848	dimer interface [polypeptide binding]; other site
266834007849	allosteric magnesium binding site [ion binding]; other site
266834007850	active site
266834007851	aspartate-rich active site metal binding site; other site
266834007852	Schiff base residues; other site
266834007853	Transcriptional regulators [Transcription]; Region: MarR; COG1846
266834007854	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
266834007855	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
266834007856	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834007857	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
266834007858	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
266834007859	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
266834007860	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
266834007861	dimer interface [polypeptide binding]; other site
266834007862	active site
266834007863	glycine-pyridoxal phosphate binding site [chemical binding]; other site
266834007864	folate binding site [chemical binding]; other site
266834007865	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
266834007866	ATP cone domain; Region: ATP-cone; pfam03477
266834007867	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
266834007868	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
266834007869	catalytic motif [active]
266834007870	Zn binding site [ion binding]; other site
266834007871	RibD C-terminal domain; Region: RibD_C; cl17279
266834007872	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
266834007873	Lumazine binding domain; Region: Lum_binding; pfam00677
266834007874	Lumazine binding domain; Region: Lum_binding; pfam00677
266834007875	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
266834007876	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837
266834007877	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
266834007878	homopentamer interface [polypeptide binding]; other site
266834007879	active site
266834007880	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
266834007881	putative RNA binding site [nucleotide binding]; other site
266834007882	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834007883	Major Facilitator Superfamily; Region: MFS_1; pfam07690
266834007884	putative substrate translocation pore; other site
266834007885	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808
266834007886	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
266834007887	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
266834007888	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
266834007889	Uncharacterized conserved protein [Function unknown]; Region: COG5452
266834007890	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
266834007891	putative phosphate acyltransferase; Provisional; Region: PRK05331
266834007892	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
266834007893	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
266834007894	dimer interface [polypeptide binding]; other site
266834007895	active site
266834007896	CoA binding pocket [chemical binding]; other site
266834007897	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
266834007898	IHF dimer interface [polypeptide binding]; other site
266834007899	IHF - DNA interface [nucleotide binding]; other site
266834007900	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
266834007901	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
266834007902	DNA binding residues [nucleotide binding]
266834007903	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
266834007904	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834007905	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
266834007906	O-Antigen ligase; Region: Wzy_C; pfam04932
266834007907	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
266834007908	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
266834007909	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
266834007910	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834007911	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
266834007912	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
266834007913	SLBB domain; Region: SLBB; pfam10531
266834007914	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
266834007915	Chain length determinant protein; Region: Wzz; pfam02706
266834007916	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
266834007917	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
266834007918	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
266834007919	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
266834007920	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
266834007921	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
266834007922	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
266834007923	trimer interface [polypeptide binding]; other site
266834007924	active site
266834007925	substrate binding site [chemical binding]; other site
266834007926	CoA binding site [chemical binding]; other site
266834007927	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
266834007928	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
266834007929	active site
266834007930	metal binding site [ion binding]; metal-binding site
266834007931	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
266834007932	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
266834007933	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
266834007934	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
266834007935	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
266834007936	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
266834007937	agmatinase; Region: agmatinase; TIGR01230
266834007938	oligomer interface [polypeptide binding]; other site
266834007939	putative active site [active]
266834007940	Mn binding site [ion binding]; other site
266834007941	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
266834007942	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
266834007943	23S rRNA interface [nucleotide binding]; other site
266834007944	L3 interface [polypeptide binding]; other site
266834007945	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
266834007946	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
266834007947	CoenzymeA binding site [chemical binding]; other site
266834007948	subunit interaction site [polypeptide binding]; other site
266834007949	PHB binding site; other site
266834007950	enoyl-CoA hydratase; Validated; Region: PRK08139
266834007951	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
266834007952	substrate binding site [chemical binding]; other site
266834007953	oxyanion hole (OAH) forming residues; other site
266834007954	trimer interface [polypeptide binding]; other site
266834007955	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
266834007956	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
266834007957	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
266834007958	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
266834007959	homodimer interface [polypeptide binding]; other site
266834007960	substrate-cofactor binding pocket; other site
266834007961	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834007962	catalytic residue [active]
266834007963	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
266834007964	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834007965	Winged helix-turn helix; Region: HTH_29; pfam13551
266834007966	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
266834007967	Integrase core domain; Region: rve; pfam00665
266834007968	Integrase core domain; Region: rve_3; pfam13683
266834007969	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
266834007970	Cytochrome P450; Region: p450; cl12078
266834007971	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
266834007972	putative catalytic site [active]
266834007973	putative metal binding site [ion binding]; other site
266834007974	putative phosphate binding site [ion binding]; other site
266834007975	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
266834007976	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
266834007977	putative active site [active]
266834007978	catalytic site [active]
266834007979	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
266834007980	putative active site [active]
266834007981	catalytic site [active]
266834007982	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
266834007983	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
266834007984	oligomer interface [polypeptide binding]; other site
266834007985	active site residues [active]
266834007986	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
266834007987	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
266834007988	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834007989	Walker A motif; other site
266834007990	ATP binding site [chemical binding]; other site
266834007991	Walker B motif; other site
266834007992	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
266834007993	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
266834007994	Found in ATP-dependent protease La (LON); Region: LON; smart00464
266834007995	Found in ATP-dependent protease La (LON); Region: LON; smart00464
266834007996	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834007997	Walker A motif; other site
266834007998	ATP binding site [chemical binding]; other site
266834007999	Walker B motif; other site
266834008000	arginine finger; other site
266834008001	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
266834008002	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
266834008003	IHF dimer interface [polypeptide binding]; other site
266834008004	IHF - DNA interface [nucleotide binding]; other site
266834008005	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
266834008006	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
266834008007	MarR family; Region: MarR; pfam01047
266834008008	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
266834008009	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
266834008010	active site
266834008011	metal binding site [ion binding]; metal-binding site
266834008012	DNA binding site [nucleotide binding]
266834008013	Uncharacterized conserved protein [Function unknown]; Region: COG4717
266834008014	P-loop containing region of AAA domain; Region: AAA_29; cl17516
266834008015	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
266834008016	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
266834008017	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
266834008018	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
266834008019	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
266834008020	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
266834008021	NADH dehydrogenase subunit D; Validated; Region: PRK06075
266834008022	NADH dehydrogenase subunit E; Validated; Region: PRK07539
266834008023	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
266834008024	putative dimer interface [polypeptide binding]; other site
266834008025	[2Fe-2S] cluster binding site [ion binding]; other site
266834008026	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
266834008027	SLBB domain; Region: SLBB; pfam10531
266834008028	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
266834008029	Uncharacterized conserved protein [Function unknown]; Region: COG3743
266834008030	NADH dehydrogenase subunit G; Validated; Region: PRK09130
266834008031	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834008032	catalytic loop [active]
266834008033	iron binding site [ion binding]; other site
266834008034	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
266834008035	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
266834008036	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
266834008037	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
266834008038	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
266834008039	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
266834008040	4Fe-4S binding domain; Region: Fer4; pfam00037
266834008041	4Fe-4S binding domain; Region: Fer4; pfam00037
266834008042	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
266834008043	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
266834008044	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
266834008045	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
266834008046	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
266834008047	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
266834008048	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
266834008049	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
266834008050	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
266834008051	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
266834008052	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
266834008053	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
266834008054	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
266834008055	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
266834008056	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
266834008057	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
266834008058	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
266834008059	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834008060	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
266834008061	dimer interface [polypeptide binding]; other site
266834008062	substrate binding site [chemical binding]; other site
266834008063	metal binding site [ion binding]; metal-binding site
266834008064	Predicted secreted protein [Function unknown]; Region: COG5454
266834008065	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
266834008066	oligomeric interface; other site
266834008067	putative active site [active]
266834008068	homodimer interface [polypeptide binding]; other site
266834008069	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
266834008070	prolyl-tRNA synthetase; Provisional; Region: PRK12325
266834008071	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
266834008072	dimer interface [polypeptide binding]; other site
266834008073	motif 1; other site
266834008074	active site
266834008075	motif 2; other site
266834008076	motif 3; other site
266834008077	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
266834008078	anticodon binding site; other site
266834008079	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
266834008080	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
266834008081	FtsX-like permease family; Region: FtsX; pfam02687
266834008082	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
266834008083	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
266834008084	Walker A/P-loop; other site
266834008085	ATP binding site [chemical binding]; other site
266834008086	Q-loop/lid; other site
266834008087	ABC transporter signature motif; other site
266834008088	Walker B; other site
266834008089	D-loop; other site
266834008090	H-loop/switch region; other site
266834008091	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
266834008092	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
266834008093	putative active site [active]
266834008094	putative PHP Thumb interface [polypeptide binding]; other site
266834008095	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
266834008096	generic binding surface II; other site
266834008097	generic binding surface I; other site
266834008098	hypothetical protein; Provisional; Region: PRK06132
266834008099	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
266834008100	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834008101	DNA polymerase IV; Provisional; Region: PRK02794
266834008102	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
266834008103	active site
266834008104	DNA binding site [nucleotide binding]
266834008105	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
266834008106	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
266834008107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834008108	active site
266834008109	phosphorylation site [posttranslational modification]
266834008110	intermolecular recognition site; other site
266834008111	dimerization interface [polypeptide binding]; other site
266834008112	response regulator PleD; Reviewed; Region: pleD; PRK09581
266834008113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834008114	active site
266834008115	phosphorylation site [posttranslational modification]
266834008116	intermolecular recognition site; other site
266834008117	dimerization interface [polypeptide binding]; other site
266834008118	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834008119	active site
266834008120	phosphorylation site [posttranslational modification]
266834008121	intermolecular recognition site; other site
266834008122	dimerization interface [polypeptide binding]; other site
266834008123	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834008124	metal binding site [ion binding]; metal-binding site
266834008125	active site
266834008126	I-site; other site
266834008127	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
266834008128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834008129	putative substrate translocation pore; other site
266834008130	Major Facilitator Superfamily; Region: MFS_1; pfam07690
266834008131	hypothetical protein; Provisional; Region: PRK05978
266834008132	ribonuclease R; Region: RNase_R; TIGR02063
266834008133	RNB domain; Region: RNB; pfam00773
266834008134	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
266834008135	RNA binding site [nucleotide binding]; other site
266834008136	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
266834008137	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
266834008138	active site
266834008139	interdomain interaction site; other site
266834008140	putative metal-binding site [ion binding]; other site
266834008141	nucleotide binding site [chemical binding]; other site
266834008142	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
266834008143	domain I; other site
266834008144	DNA binding groove [nucleotide binding]
266834008145	phosphate binding site [ion binding]; other site
266834008146	domain II; other site
266834008147	domain III; other site
266834008148	nucleotide binding site [chemical binding]; other site
266834008149	catalytic site [active]
266834008150	domain IV; other site
266834008151	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
266834008152	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
266834008153	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
266834008154	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
266834008155	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
266834008156	DNA protecting protein DprA; Region: dprA; TIGR00732
266834008157	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
266834008158	dihydroorotase; Validated; Region: PRK09059
266834008159	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
266834008160	active site
266834008161	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
266834008162	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
266834008163	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
266834008164	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
266834008165	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
266834008166	active site
266834008167	Predicted permeases [General function prediction only]; Region: COG0679
266834008168	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
266834008169	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
266834008170	metal-dependent hydrolase; Provisional; Region: PRK00685
266834008171	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
266834008172	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
266834008173	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
266834008174	hypothetical protein; Provisional; Region: PRK13687
266834008175	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
266834008176	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
266834008177	GatB domain; Region: GatB_Yqey; smart00845
266834008178	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
266834008179	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834008180	Coenzyme A binding pocket [chemical binding]; other site
266834008181	NADH dehydrogenase; Validated; Region: PRK08183
266834008182	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
266834008183	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
266834008184	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
266834008185	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
266834008186	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
266834008187	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
266834008188	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
266834008189	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
266834008190	carboxyltransferase (CT) interaction site; other site
266834008191	biotinylation site [posttranslational modification]; other site
266834008192	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
266834008193	Dehydroquinase class II; Region: DHquinase_II; pfam01220
266834008194	trimer interface [polypeptide binding]; other site
266834008195	active site
266834008196	dimer interface [polypeptide binding]; other site
266834008197	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
266834008198	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
266834008199	catalytic residues [active]
266834008200	aspartate aminotransferase; Provisional; Region: PRK05764
266834008201	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834008202	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834008203	homodimer interface [polypeptide binding]; other site
266834008204	catalytic residue [active]
266834008205	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
266834008206	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834008207	Homeodomain-like domain; Region: HTH_32; pfam13565
266834008208	DDE superfamily endonuclease; Region: DDE_3; pfam13358
266834008209	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
266834008210	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
266834008211	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
266834008212	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
266834008213	AMIN domain; Region: AMIN; pfam11741
266834008214	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
266834008215	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
266834008216	active site
266834008217	metal binding site [ion binding]; metal-binding site
266834008218	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
266834008219	Transglycosylase; Region: Transgly; pfam00912
266834008220	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
266834008221	peptide chain release factor 2; Provisional; Region: PRK07342
266834008222	This domain is found in peptide chain release factors; Region: PCRF; smart00937
266834008223	RF-1 domain; Region: RF-1; pfam00472
266834008224	ATP-NAD kinase; Region: NAD_kinase; pfam01513
266834008225	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
266834008226	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
266834008227	dimer interface [polypeptide binding]; other site
266834008228	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834008229	ligand binding site [chemical binding]; other site
266834008230	LysR family transcriptional regulator; Provisional; Region: PRK14997
266834008231	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834008232	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
266834008233	putative effector binding pocket; other site
266834008234	putative dimerization interface [polypeptide binding]; other site
266834008235	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
266834008236	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
266834008237	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
266834008238	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
266834008239	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
266834008240	elongation factor Tu; Reviewed; Region: PRK00049
266834008241	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
266834008242	G1 box; other site
266834008243	GEF interaction site [polypeptide binding]; other site
266834008244	GTP/Mg2+ binding site [chemical binding]; other site
266834008245	Switch I region; other site
266834008246	G2 box; other site
266834008247	G3 box; other site
266834008248	Switch II region; other site
266834008249	G4 box; other site
266834008250	G5 box; other site
266834008251	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
266834008252	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
266834008253	Antibiotic Binding Site [chemical binding]; other site
266834008254	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834008255	extended (e) SDRs; Region: SDR_e; cd08946
266834008256	NAD(P) binding site [chemical binding]; other site
266834008257	active site
266834008258	substrate binding site [chemical binding]; other site
266834008259	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
266834008260	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
266834008261	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
266834008262	putative homodimer interface [polypeptide binding]; other site
266834008263	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
266834008264	heterodimer interface [polypeptide binding]; other site
266834008265	homodimer interface [polypeptide binding]; other site
266834008266	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
266834008267	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
266834008268	23S rRNA interface [nucleotide binding]; other site
266834008269	L7/L12 interface [polypeptide binding]; other site
266834008270	putative thiostrepton binding site; other site
266834008271	L25 interface [polypeptide binding]; other site
266834008272	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
266834008273	mRNA/rRNA interface [nucleotide binding]; other site
266834008274	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
266834008275	23S rRNA interface [nucleotide binding]; other site
266834008276	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
266834008277	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
266834008278	core dimer interface [polypeptide binding]; other site
266834008279	peripheral dimer interface [polypeptide binding]; other site
266834008280	L10 interface [polypeptide binding]; other site
266834008281	L11 interface [polypeptide binding]; other site
266834008282	putative EF-Tu interaction site [polypeptide binding]; other site
266834008283	putative EF-G interaction site [polypeptide binding]; other site
266834008284	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
266834008285	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
266834008286	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
266834008287	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
266834008288	RPB11 interaction site [polypeptide binding]; other site
266834008289	RPB12 interaction site [polypeptide binding]; other site
266834008290	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
266834008291	RPB1 interaction site [polypeptide binding]; other site
266834008292	RPB11 interaction site [polypeptide binding]; other site
266834008293	RPB10 interaction site [polypeptide binding]; other site
266834008294	RPB3 interaction site [polypeptide binding]; other site
266834008295	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
266834008296	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
266834008297	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
266834008298	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
266834008299	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
266834008300	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
266834008301	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
266834008302	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
266834008303	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
266834008304	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
266834008305	DNA binding site [nucleotide binding]
266834008306	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
266834008307	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
266834008308	S17 interaction site [polypeptide binding]; other site
266834008309	S8 interaction site; other site
266834008310	16S rRNA interaction site [nucleotide binding]; other site
266834008311	streptomycin interaction site [chemical binding]; other site
266834008312	23S rRNA interaction site [nucleotide binding]; other site
266834008313	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
266834008314	30S ribosomal protein S7; Validated; Region: PRK05302
266834008315	elongation factor G; Reviewed; Region: PRK00007
266834008316	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
266834008317	G1 box; other site
266834008318	putative GEF interaction site [polypeptide binding]; other site
266834008319	GTP/Mg2+ binding site [chemical binding]; other site
266834008320	Switch I region; other site
266834008321	G2 box; other site
266834008322	G3 box; other site
266834008323	Switch II region; other site
266834008324	G4 box; other site
266834008325	G5 box; other site
266834008326	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
266834008327	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
266834008328	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
266834008329	elongation factor Tu; Reviewed; Region: PRK00049
266834008330	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
266834008331	G1 box; other site
266834008332	GEF interaction site [polypeptide binding]; other site
266834008333	GTP/Mg2+ binding site [chemical binding]; other site
266834008334	Switch I region; other site
266834008335	G2 box; other site
266834008336	G3 box; other site
266834008337	Switch II region; other site
266834008338	G4 box; other site
266834008339	G5 box; other site
266834008340	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
266834008341	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
266834008342	Antibiotic Binding Site [chemical binding]; other site
266834008343	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
266834008344	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
266834008345	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
266834008346	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
266834008347	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
266834008348	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
266834008349	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
266834008350	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
266834008351	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
266834008352	putative translocon binding site; other site
266834008353	protein-rRNA interface [nucleotide binding]; other site
266834008354	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
266834008355	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
266834008356	G-X-X-G motif; other site
266834008357	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
266834008358	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
266834008359	23S rRNA interface [nucleotide binding]; other site
266834008360	5S rRNA interface [nucleotide binding]; other site
266834008361	putative antibiotic binding site [chemical binding]; other site
266834008362	L25 interface [polypeptide binding]; other site
266834008363	L27 interface [polypeptide binding]; other site
266834008364	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
266834008365	23S rRNA interface [nucleotide binding]; other site
266834008366	putative translocon interaction site; other site
266834008367	signal recognition particle (SRP54) interaction site; other site
266834008368	L23 interface [polypeptide binding]; other site
266834008369	trigger factor interaction site; other site
266834008370	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
266834008371	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
266834008372	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
266834008373	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
266834008374	RNA binding site [nucleotide binding]; other site
266834008375	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
266834008376	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
266834008377	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
266834008378	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
266834008379	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
266834008380	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
266834008381	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
266834008382	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
266834008383	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
266834008384	23S rRNA interface [nucleotide binding]; other site
266834008385	L21e interface [polypeptide binding]; other site
266834008386	5S rRNA interface [nucleotide binding]; other site
266834008387	L27 interface [polypeptide binding]; other site
266834008388	L5 interface [polypeptide binding]; other site
266834008389	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
266834008390	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
266834008391	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
266834008392	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
266834008393	23S rRNA binding site [nucleotide binding]; other site
266834008394	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
266834008395	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
266834008396	SecY translocase; Region: SecY; pfam00344
266834008397	adenylate kinase; Reviewed; Region: adk; PRK00279
266834008398	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
266834008399	AMP-binding site [chemical binding]; other site
266834008400	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
266834008401	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
266834008402	30S ribosomal protein S13; Region: bact_S13; TIGR03631
266834008403	30S ribosomal protein S11; Validated; Region: PRK05309
266834008404	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
266834008405	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
266834008406	alphaNTD homodimer interface [polypeptide binding]; other site
266834008407	alphaNTD - beta interaction site [polypeptide binding]; other site
266834008408	alphaNTD - beta' interaction site [polypeptide binding]; other site
266834008409	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
266834008410	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
266834008411	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
266834008412	TMAO/DMSO reductase; Reviewed; Region: PRK05363
266834008413	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
266834008414	Moco binding site; other site
266834008415	metal coordination site [ion binding]; other site
266834008416	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
266834008417	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
266834008418	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
266834008419	protein binding site [polypeptide binding]; other site
266834008420	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
266834008421	protein binding site [polypeptide binding]; other site
266834008422	recombination factor protein RarA; Reviewed; Region: PRK13342
266834008423	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834008424	Walker A motif; other site
266834008425	ATP binding site [chemical binding]; other site
266834008426	Walker B motif; other site
266834008427	arginine finger; other site
266834008428	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
266834008429	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
266834008430	Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387
266834008431	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
266834008432	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834008433	motif II; other site
266834008434	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
266834008435	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
266834008436	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
266834008437	active site
266834008438	camphor resistance protein CrcB; Provisional; Region: PRK14195
266834008439	S-formylglutathione hydrolase; Region: PLN02442
266834008440	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
266834008441	Predicted membrane protein [Function unknown]; Region: COG4291
266834008442	hypothetical protein; Validated; Region: PRK00124
266834008443	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
266834008444	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
266834008445	substrate binding site [chemical binding]; other site
266834008446	catalytic Zn binding site [ion binding]; other site
266834008447	NAD binding site [chemical binding]; other site
266834008448	structural Zn binding site [ion binding]; other site
266834008449	dimer interface [polypeptide binding]; other site
266834008450	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834008451	non-specific DNA binding site [nucleotide binding]; other site
266834008452	salt bridge; other site
266834008453	sequence-specific DNA binding site [nucleotide binding]; other site
266834008454	lipoate-protein ligase B; Provisional; Region: PRK14341
266834008455	PrkA family serine protein kinase; Provisional; Region: PRK15455
266834008456	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
266834008457	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
266834008458	Uncharacterized conserved protein [Function unknown]; Region: COG2718
266834008459	SpoVR family protein; Provisional; Region: PRK11767
266834008460	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
266834008461	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
266834008462	active site
266834008463	catalytic residues [active]
266834008464	metal binding site [ion binding]; metal-binding site
266834008465	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
266834008466	MgtE intracellular N domain; Region: MgtE_N; smart00924
266834008467	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
266834008468	Divalent cation transporter; Region: MgtE; cl00786
266834008469	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
266834008470	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
266834008471	DNA binding residues [nucleotide binding]
266834008472	putative dimer interface [polypeptide binding]; other site
266834008473	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
266834008474	Predicted membrane protein [Function unknown]; Region: COG3503
266834008475	Predicted membrane protein [Function unknown]; Region: COG3821
266834008476	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
266834008477	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
266834008478	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
266834008479	Uncharacterized conserved protein [Function unknown]; Region: COG5458
266834008480	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
266834008481	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
266834008482	Sporulation related domain; Region: SPOR; pfam05036
266834008483	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
266834008484	PilZ domain; Region: PilZ; pfam07238
266834008485	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
266834008486	PAS domain; Region: PAS_5; pfam07310
266834008487	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
266834008488	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
266834008489	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
266834008490	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
266834008491	nucleophile elbow; other site
266834008492	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
266834008493	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
266834008494	GTP cyclohydrolase I; Provisional; Region: PLN03044
266834008495	active site
266834008496	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
266834008497	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
266834008498	trimerization site [polypeptide binding]; other site
266834008499	active site
266834008500	hypothetical protein; Validated; Region: PRK00041
266834008501	Uncharacterized conserved protein [Function unknown]; Region: COG5502
266834008502	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
266834008503	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
266834008504	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
266834008505	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
266834008506	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
266834008507	active site
266834008508	dimer interface [polypeptide binding]; other site
266834008509	motif 1; other site
266834008510	motif 2; other site
266834008511	motif 3; other site
266834008512	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
266834008513	anticodon binding site; other site
266834008514	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
266834008515	putative FMN binding site [chemical binding]; other site
266834008516	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
266834008517	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
266834008518	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
266834008519	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
266834008520	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834008521	Coenzyme A binding pocket [chemical binding]; other site
266834008522	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
266834008523	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834008524	Mg2+ binding site [ion binding]; other site
266834008525	G-X-G motif; other site
266834008526	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
266834008527	anchoring element; other site
266834008528	dimer interface [polypeptide binding]; other site
266834008529	ATP binding site [chemical binding]; other site
266834008530	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
266834008531	active site
266834008532	metal binding site [ion binding]; metal-binding site
266834008533	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
266834008534	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
266834008535	FAD binding domain; Region: FAD_binding_4; pfam01565
266834008536	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
266834008537	Uncharacterized conserved protein [Function unknown]; Region: COG2353
266834008538	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
266834008539	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
266834008540	triosephosphate isomerase; Provisional; Region: PRK14565
266834008541	substrate binding site [chemical binding]; other site
266834008542	dimer interface [polypeptide binding]; other site
266834008543	catalytic triad [active]
266834008544	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
266834008545	CTP synthetase; Validated; Region: pyrG; PRK05380
266834008546	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
266834008547	Catalytic site [active]
266834008548	active site
266834008549	UTP binding site [chemical binding]; other site
266834008550	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
266834008551	active site
266834008552	putative oxyanion hole; other site
266834008553	catalytic triad [active]
266834008554	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
266834008555	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
266834008556	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
266834008557	enolase; Provisional; Region: eno; PRK00077
266834008558	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
266834008559	dimer interface [polypeptide binding]; other site
266834008560	metal binding site [ion binding]; metal-binding site
266834008561	substrate binding pocket [chemical binding]; other site
266834008562	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
266834008563	Septum formation initiator; Region: DivIC; pfam04977
266834008564	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
266834008565	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
266834008566	tetramer interface [polypeptide binding]; other site
266834008567	TPP-binding site [chemical binding]; other site
266834008568	heterodimer interface [polypeptide binding]; other site
266834008569	phosphorylation loop region [posttranslational modification]
266834008570	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
266834008571	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
266834008572	E3 interaction surface; other site
266834008573	lipoyl attachment site [posttranslational modification]; other site
266834008574	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
266834008575	alpha subunit interface [polypeptide binding]; other site
266834008576	TPP binding site [chemical binding]; other site
266834008577	heterodimer interface [polypeptide binding]; other site
266834008578	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
266834008579	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
266834008580	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
266834008581	E3 interaction surface; other site
266834008582	lipoyl attachment site [posttranslational modification]; other site
266834008583	e3 binding domain; Region: E3_binding; pfam02817
266834008584	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
266834008585	SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839
266834008586	active site
266834008587	catalytic triad [active]
266834008588	oxyanion hole [active]
266834008589	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834008590	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
266834008591	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
266834008592	Coenzyme A binding pocket [chemical binding]; other site
266834008593	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
266834008594	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
266834008595	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834008596	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
266834008597	Predicted membrane protein [Function unknown]; Region: COG2261
266834008598	lipoyl synthase; Provisional; Region: PRK05481
266834008599	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
266834008600	FeS/SAM binding site; other site
266834008601	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
266834008602	putative coenzyme Q binding site [chemical binding]; other site
266834008603	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
266834008604	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
266834008605	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
266834008606	substrate binding site; other site
266834008607	dimer interface; other site
266834008608	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
266834008609	homotrimer interaction site [polypeptide binding]; other site
266834008610	zinc binding site [ion binding]; other site
266834008611	CDP-binding sites; other site
266834008612	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
266834008613	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
266834008614	FMN binding site [chemical binding]; other site
266834008615	active site
266834008616	catalytic residues [active]
266834008617	substrate binding site [chemical binding]; other site
266834008618	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
266834008619	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834008620	dimer interface [polypeptide binding]; other site
266834008621	phosphorylation site [posttranslational modification]
266834008622	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834008623	ATP binding site [chemical binding]; other site
266834008624	Mg2+ binding site [ion binding]; other site
266834008625	G-X-G motif; other site
266834008626	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
266834008627	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834008628	active site
266834008629	phosphorylation site [posttranslational modification]
266834008630	intermolecular recognition site; other site
266834008631	dimerization interface [polypeptide binding]; other site
266834008632	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834008633	Walker A motif; other site
266834008634	ATP binding site [chemical binding]; other site
266834008635	Walker B motif; other site
266834008636	arginine finger; other site
266834008637	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
266834008638	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
266834008639	HAMP domain; Region: HAMP; pfam00672
266834008640	dimerization interface [polypeptide binding]; other site
266834008641	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834008642	dimer interface [polypeptide binding]; other site
266834008643	phosphorylation site [posttranslational modification]
266834008644	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834008645	ATP binding site [chemical binding]; other site
266834008646	Mg2+ binding site [ion binding]; other site
266834008647	G-X-G motif; other site
266834008648	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
266834008649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834008650	active site
266834008651	phosphorylation site [posttranslational modification]
266834008652	intermolecular recognition site; other site
266834008653	dimerization interface [polypeptide binding]; other site
266834008654	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834008655	Walker A motif; other site
266834008656	ATP binding site [chemical binding]; other site
266834008657	Walker B motif; other site
266834008658	arginine finger; other site
266834008659	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
266834008660	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
266834008661	TrkA-N domain; Region: TrkA_N; pfam02254
266834008662	TrkA-C domain; Region: TrkA_C; pfam02080
266834008663	TrkA-N domain; Region: TrkA_N; pfam02254
266834008664	TrkA-C domain; Region: TrkA_C; pfam02080
266834008665	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
266834008666	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
266834008667	homodimer interface [polypeptide binding]; other site
266834008668	substrate-cofactor binding pocket; other site
266834008669	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834008670	catalytic residue [active]
266834008671	bacterial Hfq-like; Region: Hfq; cd01716
266834008672	hexamer interface [polypeptide binding]; other site
266834008673	Sm1 motif; other site
266834008674	RNA binding site [nucleotide binding]; other site
266834008675	Sm2 motif; other site
266834008676	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
266834008677	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
266834008678	HflX GTPase family; Region: HflX; cd01878
266834008679	G1 box; other site
266834008680	GTP/Mg2+ binding site [chemical binding]; other site
266834008681	Switch I region; other site
266834008682	G2 box; other site
266834008683	G3 box; other site
266834008684	Switch II region; other site
266834008685	G4 box; other site
266834008686	G5 box; other site
266834008687	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834008688	Winged helix-turn helix; Region: HTH_29; pfam13551
266834008689	Homeodomain-like domain; Region: HTH_32; pfam13565
266834008690	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
266834008691	Integrase core domain; Region: rve; pfam00665
266834008692	Integrase core domain; Region: rve_3; pfam13683
266834008693	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
266834008694	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
266834008695	homodimer interface [polypeptide binding]; other site
266834008696	metal binding site [ion binding]; metal-binding site
266834008697	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
266834008698	homodimer interface [polypeptide binding]; other site
266834008699	active site
266834008700	putative chemical substrate binding site [chemical binding]; other site
266834008701	metal binding site [ion binding]; metal-binding site
266834008702	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
266834008703	nucleoside/Zn binding site; other site
266834008704	dimer interface [polypeptide binding]; other site
266834008705	catalytic motif [active]
266834008706	siroheme synthase; Provisional; Region: cysG; PRK10637
266834008707	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
266834008708	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
266834008709	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
266834008710	active site
266834008711	SAM binding site [chemical binding]; other site
266834008712	homodimer interface [polypeptide binding]; other site
266834008713	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
266834008714	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
266834008715	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
266834008716	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
266834008717	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749
266834008718	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
266834008719	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
266834008720	FAD binding pocket [chemical binding]; other site
266834008721	FAD binding motif [chemical binding]; other site
266834008722	phosphate binding motif [ion binding]; other site
266834008723	beta-alpha-beta structure motif; other site
266834008724	NAD binding pocket [chemical binding]; other site
266834008725	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
266834008726	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
266834008727	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
266834008728	Walker A/P-loop; other site
266834008729	ATP binding site [chemical binding]; other site
266834008730	Q-loop/lid; other site
266834008731	ABC transporter signature motif; other site
266834008732	Walker B; other site
266834008733	D-loop; other site
266834008734	H-loop/switch region; other site
266834008735	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834008736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834008737	dimer interface [polypeptide binding]; other site
266834008738	conserved gate region; other site
266834008739	putative PBP binding loops; other site
266834008740	ABC-ATPase subunit interface; other site
266834008741	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
266834008742	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
266834008743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834008744	dimer interface [polypeptide binding]; other site
266834008745	conserved gate region; other site
266834008746	putative PBP binding loops; other site
266834008747	ABC-ATPase subunit interface; other site
266834008748	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
266834008749	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834008750	substrate binding pocket [chemical binding]; other site
266834008751	membrane-bound complex binding site; other site
266834008752	hinge residues; other site
266834008753	cystathionine beta-lyase; Provisional; Region: PRK05967
266834008754	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
266834008755	homodimer interface [polypeptide binding]; other site
266834008756	substrate-cofactor binding pocket; other site
266834008757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834008758	catalytic residue [active]
266834008759	salicylate hydroxylase; Provisional; Region: PRK08163
266834008760	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
266834008761	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
266834008762	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
266834008763	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
266834008764	serine acetyltransferase; Provisional; Region: cysE; PRK11132
266834008765	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
266834008766	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
266834008767	trimer interface [polypeptide binding]; other site
266834008768	active site
266834008769	substrate binding site [chemical binding]; other site
266834008770	CoA binding site [chemical binding]; other site
266834008771	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
266834008772	Phasin protein; Region: Phasin_2; pfam09361
266834008773	Uncharacterized conserved protein [Function unknown]; Region: COG2127
266834008774	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
266834008775	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834008776	Walker A motif; other site
266834008777	ATP binding site [chemical binding]; other site
266834008778	Walker B motif; other site
266834008779	arginine finger; other site
266834008780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834008781	Walker A motif; other site
266834008782	ATP binding site [chemical binding]; other site
266834008783	Walker B motif; other site
266834008784	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
266834008785	AzlC protein; Region: AzlC; pfam03591
266834008786	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
266834008787	HIT family signature motif; other site
266834008788	catalytic residue [active]
266834008789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
266834008790	Protein of unknown function, DUF482; Region: DUF482; pfam04339
266834008791	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
266834008792	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
266834008793	putative active site [active]
266834008794	catalytic site [active]
266834008795	putative metal binding site [ion binding]; other site
266834008796	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
266834008797	homotrimer interaction site [polypeptide binding]; other site
266834008798	putative active site [active]
266834008799	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
266834008800	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
266834008801	rRNA interaction site [nucleotide binding]; other site
266834008802	S8 interaction site; other site
266834008803	putative laminin-1 binding site; other site
266834008804	elongation factor Ts; Provisional; Region: tsf; PRK09377
266834008805	UBA/TS-N domain; Region: UBA; pfam00627
266834008806	Elongation factor TS; Region: EF_TS; pfam00889
266834008807	Elongation factor TS; Region: EF_TS; pfam00889
266834008808	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
266834008809	putative nucleotide binding site [chemical binding]; other site
266834008810	uridine monophosphate binding site [chemical binding]; other site
266834008811	homohexameric interface [polypeptide binding]; other site
266834008812	ribosome recycling factor; Reviewed; Region: frr; PRK00083
266834008813	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
266834008814	hinge region; other site
266834008815	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
266834008816	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
266834008817	catalytic residue [active]
266834008818	putative FPP diphosphate  binding site; other site
266834008819	putative FPP binding hydrophobic cleft; other site
266834008820	dimer interface [polypeptide binding]; other site
266834008821	putative IPP diphosphate binding site; other site
266834008822	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
266834008823	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
266834008824	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
266834008825	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
266834008826	active site
266834008827	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
266834008828	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
266834008829	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
266834008830	putative substrate binding region [chemical binding]; other site
266834008831	putative substrate binding region [chemical binding]; other site
266834008832	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
266834008833	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
266834008834	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
266834008835	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
266834008836	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
266834008837	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
266834008838	Surface antigen; Region: Bac_surface_Ag; pfam01103
266834008839	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
266834008840	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
266834008841	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
266834008842	trimer interface [polypeptide binding]; other site
266834008843	active site
266834008844	UDP-GlcNAc binding site [chemical binding]; other site
266834008845	lipid binding site [chemical binding]; lipid-binding site
266834008846	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
266834008847	Acyl-[acyl carrier protein]; Region: LpxA; COG1043
266834008848	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
266834008849	active site
266834008850	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494
266834008851	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
266834008852	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
266834008853	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
266834008854	GIY-YIG motif/motif A; other site
266834008855	putative active site [active]
266834008856	putative metal binding site [ion binding]; other site
266834008857	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
266834008858	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
266834008859	dimer interface [polypeptide binding]; other site
266834008860	active site
266834008861	citrylCoA binding site [chemical binding]; other site
266834008862	NADH binding [chemical binding]; other site
266834008863	cationic pore residues; other site
266834008864	oxalacetate/citrate binding site [chemical binding]; other site
266834008865	coenzyme A binding site [chemical binding]; other site
266834008866	catalytic triad [active]
266834008867	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
266834008868	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
266834008869	Competence protein; Region: Competence; pfam03772
266834008870	tonB-system energizer ExbB; Region: exbB; TIGR02797
266834008871	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
266834008872	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
266834008873	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
266834008874	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
266834008875	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834008876	S-adenosylmethionine binding site [chemical binding]; other site
266834008877	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
266834008878	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827
266834008879	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
266834008880	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
266834008881	HIGH motif; other site
266834008882	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
266834008883	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
266834008884	active site
266834008885	KMSKS motif; other site
266834008886	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
266834008887	tRNA binding surface [nucleotide binding]; other site
266834008888	anticodon binding site; other site
266834008889	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
266834008890	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
266834008891	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
266834008892	Sel1-like repeats; Region: SEL1; smart00671
266834008893	Sel1-like repeats; Region: SEL1; smart00671
266834008894	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
266834008895	putative catalytic site [active]
266834008896	putative phosphate binding site [ion binding]; other site
266834008897	active site
266834008898	metal binding site A [ion binding]; metal-binding site
266834008899	DNA binding site [nucleotide binding]
266834008900	putative AP binding site [nucleotide binding]; other site
266834008901	putative metal binding site B [ion binding]; other site
266834008902	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
266834008903	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
266834008904	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
266834008905	putative active site [active]
266834008906	catalytic site [active]
266834008907	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
266834008908	putative active site [active]
266834008909	catalytic site [active]
266834008910	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
266834008911	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
266834008912	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
266834008913	Zn2+ binding site [ion binding]; other site
266834008914	Mg2+ binding site [ion binding]; other site
266834008915	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
266834008916	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
266834008917	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
266834008918	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
266834008919	active site
266834008920	HIGH motif; other site
266834008921	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
266834008922	KMSK motif region; other site
266834008923	tRNA binding surface [nucleotide binding]; other site
266834008924	DALR anticodon binding domain; Region: DALR_1; smart00836
266834008925	anticodon binding site; other site
266834008926	Sporulation related domain; Region: SPOR; pfam05036
266834008927	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
266834008928	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
266834008929	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
266834008930	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
266834008931	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
266834008932	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
266834008933	Walker A/P-loop; other site
266834008934	ATP binding site [chemical binding]; other site
266834008935	Q-loop/lid; other site
266834008936	ABC transporter signature motif; other site
266834008937	Walker B; other site
266834008938	D-loop; other site
266834008939	H-loop/switch region; other site
266834008940	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
266834008941	sec-independent translocase; Provisional; Region: PRK00708
266834008942	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
266834008943	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
266834008944	seryl-tRNA synthetase; Provisional; Region: PRK05431
266834008945	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
266834008946	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
266834008947	dimer interface [polypeptide binding]; other site
266834008948	active site
266834008949	motif 1; other site
266834008950	motif 2; other site
266834008951	motif 3; other site
266834008952	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
266834008953	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
266834008954	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834008955	S-adenosylmethionine binding site [chemical binding]; other site
266834008956	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
266834008957	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
266834008958	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
266834008959	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
266834008960	Peptidase family M23; Region: Peptidase_M23; pfam01551
266834008961	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
266834008962	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834008963	Walker A motif; other site
266834008964	ATP binding site [chemical binding]; other site
266834008965	Walker B motif; other site
266834008966	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
266834008967	bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726
266834008968	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
266834008969	Protein export membrane protein; Region: SecD_SecF; cl14618
266834008970	Protein export membrane protein; Region: SecD_SecF; pfam02355
266834008971	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
266834008972	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
266834008973	substrate binding pocket [chemical binding]; other site
266834008974	aspartate-rich region 1; other site
266834008975	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
266834008976	Glucose inhibited division protein A; Region: GIDA; pfam01134
266834008977	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
266834008978	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
266834008979	trigger factor; Provisional; Region: tig; PRK01490
266834008980	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
266834008981	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
266834008982	glycine dehydrogenase; Provisional; Region: PRK05367
266834008983	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
266834008984	tetramer interface [polypeptide binding]; other site
266834008985	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834008986	catalytic residue [active]
266834008987	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
266834008988	tetramer interface [polypeptide binding]; other site
266834008989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834008990	catalytic residue [active]
266834008991	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
266834008992	lipoyl attachment site [posttranslational modification]; other site
266834008993	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
266834008994	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
266834008995	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
266834008996	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
266834008997	CRISPR-associated protein, Csx11 family; Region: cas_csx11; TIGR02682
266834008998	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834008999	MULE transposase domain; Region: MULE; pfam10551
266834009000	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
266834009001	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834009002	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
266834009003	dimer interface [polypeptide binding]; other site
266834009004	N-terminal domain interface [polypeptide binding]; other site
266834009005	substrate binding pocket (H-site) [chemical binding]; other site
266834009006	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
266834009007	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
266834009008	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
266834009009	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
266834009010	active site
266834009011	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
266834009012	TSCPD domain; Region: TSCPD; pfam12637
266834009013	Uncharacterized conserved protein [Function unknown]; Region: COG1801
266834009014	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
266834009015	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
266834009016	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
266834009017	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
266834009018	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
266834009019	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
266834009020	dimer interface [polypeptide binding]; other site
266834009021	ssDNA binding site [nucleotide binding]; other site
266834009022	tetramer (dimer of dimers) interface [polypeptide binding]; other site
266834009023	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
266834009024	DNA gyrase subunit A; Validated; Region: PRK05560
266834009025	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
266834009026	CAP-like domain; other site
266834009027	active site
266834009028	primary dimer interface [polypeptide binding]; other site
266834009029	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
266834009030	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
266834009031	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
266834009032	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
266834009033	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
266834009034	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
266834009035	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
266834009036	N-acetyl-D-glucosamine binding site [chemical binding]; other site
266834009037	catalytic residue [active]
266834009038	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
266834009039	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834009040	Coenzyme A binding pocket [chemical binding]; other site
266834009041	Streptomycin 6-kinase [Defense mechanisms]; Region: StrB; COG3570
266834009042	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
266834009043	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
266834009044	FMN binding site [chemical binding]; other site
266834009045	active site
266834009046	substrate binding site [chemical binding]; other site
266834009047	catalytic residue [active]
266834009048	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834009049	dimerization interface [polypeptide binding]; other site
266834009050	putative DNA binding site [nucleotide binding]; other site
266834009051	putative Zn2+ binding site [ion binding]; other site
266834009052	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834009053	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834009054	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834009055	putative effector binding pocket; other site
266834009056	dimerization interface [polypeptide binding]; other site
266834009057	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
266834009058	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
266834009059	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834009060	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834009061	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834009062	putative DNA binding site [nucleotide binding]; other site
266834009063	putative Zn2+ binding site [ion binding]; other site
266834009064	AsnC family; Region: AsnC_trans_reg; pfam01037
266834009065	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
266834009066	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
266834009067	putative metal binding site; other site
266834009068	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834009069	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
266834009070	putative ADP-binding pocket [chemical binding]; other site
266834009071	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834009072	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
266834009073	putative ADP-binding pocket [chemical binding]; other site
266834009074	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
266834009075	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834009076	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
266834009077	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
266834009078	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
266834009079	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834009080	putative substrate translocation pore; other site
266834009081	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
266834009082	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
266834009083	ATP-grasp domain; Region: ATP-grasp_4; cl17255
266834009084	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
266834009085	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
266834009086	ATP-grasp domain; Region: ATP-grasp_4; cl17255
266834009087	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
266834009088	IMP binding site; other site
266834009089	dimer interface [polypeptide binding]; other site
266834009090	partial ornithine binding site; other site
266834009091	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
266834009092	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
266834009093	putative NAD(P) binding site [chemical binding]; other site
266834009094	catalytic Zn binding site [ion binding]; other site
266834009095	Predicted metalloprotease [General function prediction only]; Region: COG2321
266834009096	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
266834009097	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834009098	Major Facilitator Superfamily; Region: MFS_1; pfam07690
266834009099	putative substrate translocation pore; other site
266834009100	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
266834009101	putative efflux protein, MATE family; Region: matE; TIGR00797
266834009102	cation binding site [ion binding]; other site
266834009103	Protein of unknown function DUF86; Region: DUF86; cl01031
266834009104	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
266834009105	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
266834009106	active site
266834009107	(T/H)XGH motif; other site
266834009108	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
266834009109	active site
266834009110	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
266834009111	active site
266834009112	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
266834009113	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
266834009114	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
266834009115	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
266834009116	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
266834009117	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834009118	substrate binding pocket [chemical binding]; other site
266834009119	membrane-bound complex binding site; other site
266834009120	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
266834009121	classical (c) SDRs; Region: SDR_c; cd05233
266834009122	NAD(P) binding site [chemical binding]; other site
266834009123	active site
266834009124	SEC-C motif; Region: SEC-C; pfam02810
266834009125	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
266834009126	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
266834009127	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
266834009128	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834009129	classical (c) SDRs; Region: SDR_c; cd05233
266834009130	NAD(P) binding site [chemical binding]; other site
266834009131	active site
266834009132	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834009133	putative substrate translocation pore; other site
266834009134	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
266834009135	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834009136	DNA binding site [nucleotide binding]
266834009137	Predicted integral membrane protein [Function unknown]; Region: COG5616
266834009138	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834009139	TPR motif; other site
266834009140	binding surface
266834009141	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834009142	TPR motif; other site
266834009143	binding surface
266834009144	Uncharacterized conserved protein [Function unknown]; Region: COG3791
266834009145	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
266834009146	Winged helix-turn helix; Region: HTH_29; pfam13551
266834009147	DNA-binding interface [nucleotide binding]; DNA binding site
266834009148	Homeodomain-like domain; Region: HTH_32; pfam13565
266834009149	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
266834009150	putative hydrolase; Provisional; Region: PRK02113
266834009151	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
266834009152	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
266834009153	active site
266834009154	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
266834009155	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
266834009156	active site
266834009157	HIGH motif; other site
266834009158	KMSKS motif; other site
266834009159	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
266834009160	tRNA binding surface [nucleotide binding]; other site
266834009161	anticodon binding site; other site
266834009162	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538
266834009163	metal binding site [ion binding]; metal-binding site
266834009164	DNA polymerase III subunit delta'; Validated; Region: PRK09112
266834009165	AAA ATPase domain; Region: AAA_16; pfam13191
266834009166	DNA polymerase III subunit delta'; Validated; Region: PRK08485
266834009167	Peptidase family M23; Region: Peptidase_M23; pfam01551
266834009168	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
266834009169	Thymidylate kinase; Region: Thymidylate_kin; pfam02223
266834009170	TMP-binding site; other site
266834009171	ATP-binding site [chemical binding]; other site
266834009172	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
266834009173	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
266834009174	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
266834009175	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
266834009176	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
266834009177	Uncharacterized conserved protein [Function unknown]; Region: COG5361
266834009178	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
266834009179	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
266834009180	Uncharacterized conserved protein [Function unknown]; Region: COG5361
266834009181	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
266834009182	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
266834009183	LexA repressor; Validated; Region: PRK00215
266834009184	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
266834009185	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
266834009186	Catalytic site [active]
266834009187	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
266834009188	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
266834009189	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
266834009190	putative active site [active]
266834009191	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
266834009192	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
266834009193	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834009194	short chain dehydrogenase; Provisional; Region: PRK06101
266834009195	NAD(P) binding site [chemical binding]; other site
266834009196	active site
266834009197	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
266834009198	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
266834009199	dimer interface [polypeptide binding]; other site
266834009200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834009201	catalytic residue [active]
266834009202	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
266834009203	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
266834009204	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
266834009205	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
266834009206	active site residue [active]
266834009207	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
266834009208	active site residue [active]
266834009209	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
266834009210	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
266834009211	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
266834009212	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
266834009213	hexamer interface [polypeptide binding]; other site
266834009214	ligand binding site [chemical binding]; other site
266834009215	putative active site [active]
266834009216	NAD(P) binding site [chemical binding]; other site
266834009217	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834009218	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834009219	putative DNA binding site [nucleotide binding]; other site
266834009220	putative Zn2+ binding site [ion binding]; other site
266834009221	AsnC family; Region: AsnC_trans_reg; pfam01037
266834009222	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
266834009223	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
266834009224	active site
266834009225	metal binding site [ion binding]; metal-binding site
266834009226	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
266834009227	Uncharacterized conserved protein [Function unknown]; Region: COG5453
266834009228	threonine dehydratase; Validated; Region: PRK08639
266834009229	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
266834009230	tetramer interface [polypeptide binding]; other site
266834009231	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834009232	catalytic residue [active]
266834009233	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
266834009234	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
266834009235	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
266834009236	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
266834009237	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
266834009238	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
266834009239	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
266834009240	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
266834009241	putative MPT binding site; other site
266834009242	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
266834009243	active site
266834009244	Uncharacterized conserved protein [Function unknown]; Region: COG0062
266834009245	putative carbohydrate kinase; Provisional; Region: PRK10565
266834009246	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
266834009247	putative substrate binding site [chemical binding]; other site
266834009248	putative ATP binding site [chemical binding]; other site
266834009249	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
266834009250	Nitrogen regulatory protein P-II; Region: P-II; smart00938
266834009251	glutamine synthetase; Provisional; Region: glnA; PRK09469
266834009252	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
266834009253	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
266834009254	Uncharacterized conserved protein [Function unknown]; Region: COG3785
266834009255	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
266834009256	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
266834009257	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
266834009258	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
266834009259	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
266834009260	catalytic residues [active]
266834009261	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
266834009262	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834009263	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834009264	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
266834009265	Sulfatase; Region: Sulfatase; pfam00884
266834009266	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
266834009267	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
266834009268	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
266834009269	putative catalytic site [active]
266834009270	putative phosphate binding site [ion binding]; other site
266834009271	active site
266834009272	metal binding site A [ion binding]; metal-binding site
266834009273	DNA binding site [nucleotide binding]
266834009274	putative AP binding site [nucleotide binding]; other site
266834009275	putative metal binding site B [ion binding]; other site
266834009276	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
266834009277	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
266834009278	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
266834009279	ATP binding site [chemical binding]; other site
266834009280	putative Mg++ binding site [ion binding]; other site
266834009281	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
266834009282	nucleotide binding region [chemical binding]; other site
266834009283	ATP-binding site [chemical binding]; other site
266834009284	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
266834009285	Uncharacterized conserved protein [Function unknown]; Region: COG2938
266834009286	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
266834009287	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
266834009288	generic binding surface II; other site
266834009289	ssDNA binding site; other site
266834009290	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
266834009291	ATP binding site [chemical binding]; other site
266834009292	putative Mg++ binding site [ion binding]; other site
266834009293	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
266834009294	nucleotide binding region [chemical binding]; other site
266834009295	ATP-binding site [chemical binding]; other site
266834009296	Uncharacterized conserved protein [Function unknown]; Region: COG2928
266834009297	putative acetyltransferase; Provisional; Region: PRK03624
266834009298	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834009299	Coenzyme A binding pocket [chemical binding]; other site
266834009300	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
266834009301	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
266834009302	glutaminase active site [active]
266834009303	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
266834009304	dimer interface [polypeptide binding]; other site
266834009305	active site
266834009306	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
266834009307	dimer interface [polypeptide binding]; other site
266834009308	active site
266834009309	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
266834009310	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
266834009311	Substrate binding site; other site
266834009312	Mg++ binding site; other site
266834009313	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
266834009314	active site
266834009315	substrate binding site [chemical binding]; other site
266834009316	CoA binding site [chemical binding]; other site
266834009317	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
266834009318	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
266834009319	PhoU domain; Region: PhoU; pfam01895
266834009320	PhoU domain; Region: PhoU; pfam01895
266834009321	SurA N-terminal domain; Region: SurA_N_3; cl07813
266834009322	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
266834009323	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
266834009324	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
266834009325	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
266834009326	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
266834009327	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
266834009328	active site
266834009329	ribulose/triose binding site [chemical binding]; other site
266834009330	phosphate binding site [ion binding]; other site
266834009331	substrate (anthranilate) binding pocket [chemical binding]; other site
266834009332	product (indole) binding pocket [chemical binding]; other site
266834009333	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
266834009334	trimer interface [polypeptide binding]; other site
266834009335	dimer interface [polypeptide binding]; other site
266834009336	putative active site [active]
266834009337	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
266834009338	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
266834009339	dimer interface [polypeptide binding]; other site
266834009340	putative functional site; other site
266834009341	putative MPT binding site; other site
266834009342	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
266834009343	Domain of unknown function DUF21; Region: DUF21; pfam01595
266834009344	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
266834009345	Transporter associated domain; Region: CorC_HlyC; smart01091
266834009346	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834009347	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834009348	DNA-binding site [nucleotide binding]; DNA binding site
266834009349	FCD domain; Region: FCD; pfam07729
266834009350	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
266834009351	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
266834009352	putative ligand binding site [chemical binding]; other site
266834009353	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834009354	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
266834009355	TM-ABC transporter signature motif; other site
266834009356	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834009357	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
266834009358	TM-ABC transporter signature motif; other site
266834009359	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
266834009360	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834009361	Walker A/P-loop; other site
266834009362	ATP binding site [chemical binding]; other site
266834009363	Q-loop/lid; other site
266834009364	ABC transporter signature motif; other site
266834009365	Walker B; other site
266834009366	D-loop; other site
266834009367	H-loop/switch region; other site
266834009368	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834009369	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
266834009370	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
266834009371	NADP binding site [chemical binding]; other site
266834009372	dimer interface [polypeptide binding]; other site
266834009373	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
266834009374	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
266834009375	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
266834009376	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
266834009377	Predicted permeases [General function prediction only]; Region: COG0679
266834009378	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
266834009379	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
266834009380	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
266834009381	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
266834009382	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
266834009383	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
266834009384	conserved cys residue [active]
266834009385	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834009386	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
266834009387	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cl00720
266834009388	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834009389	classical (c) SDRs; Region: SDR_c; cd05233
266834009390	NAD(P) binding site [chemical binding]; other site
266834009391	active site
266834009392	acyl-CoA synthetase; Validated; Region: PRK07470
266834009393	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
266834009394	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
266834009395	acyl-activating enzyme (AAE) consensus motif; other site
266834009396	acyl-activating enzyme (AAE) consensus motif; other site
266834009397	putative AMP binding site [chemical binding]; other site
266834009398	putative active site [active]
266834009399	putative CoA binding site [chemical binding]; other site
266834009400	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
266834009401	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
266834009402	active site
266834009403	Transcriptional regulator [Transcription]; Region: IclR; COG1414
266834009404	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
266834009405	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834009406	classical (c) SDRs; Region: SDR_c; cd05233
266834009407	NAD(P) binding site [chemical binding]; other site
266834009408	active site
266834009409	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
266834009410	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
266834009411	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
266834009412	DctM-like transporters; Region: DctM; pfam06808
266834009413	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
266834009414	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
266834009415	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834009416	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834009417	NAD(P) binding site [chemical binding]; other site
266834009418	active site
266834009419	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
266834009420	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
266834009421	PYR/PP interface [polypeptide binding]; other site
266834009422	dimer interface [polypeptide binding]; other site
266834009423	TPP binding site [chemical binding]; other site
266834009424	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
266834009425	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
266834009426	TPP-binding site [chemical binding]; other site
266834009427	dimer interface [polypeptide binding]; other site
266834009428	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
266834009429	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
266834009430	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
266834009431	DctM-like transporters; Region: DctM; pfam06808
266834009432	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
266834009433	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
266834009434	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
266834009435	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
266834009436	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834009437	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
266834009438	dimerization interface [polypeptide binding]; other site
266834009439	substrate binding pocket [chemical binding]; other site
266834009440	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
266834009441	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
266834009442	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
266834009443	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
266834009444	catalytic residue [active]
266834009445	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834009446	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834009447	putative DNA binding site [nucleotide binding]; other site
266834009448	putative Zn2+ binding site [ion binding]; other site
266834009449	AsnC family; Region: AsnC_trans_reg; pfam01037
266834009450	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
266834009451	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
266834009452	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803
266834009453	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834009454	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834009455	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
266834009456	substrate binding pocket [chemical binding]; other site
266834009457	dimerization interface [polypeptide binding]; other site
266834009458	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834009459	MULE transposase domain; Region: MULE; pfam10551
266834009460	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
266834009461	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
266834009462	Uncharacterized conserved protein [Function unknown]; Region: COG1430
266834009463	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
266834009464	DNA-binding site [nucleotide binding]; DNA binding site
266834009465	RNA-binding motif; other site
266834009466	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
266834009467	DNA-binding site [nucleotide binding]; DNA binding site
266834009468	RNA-binding motif; other site
266834009469	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834009470	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
266834009471	dimer interface [polypeptide binding]; other site
266834009472	active site
266834009473	metal binding site [ion binding]; metal-binding site
266834009474	glutathione binding site [chemical binding]; other site
266834009475	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
266834009476	Peptidase M15; Region: Peptidase_M15_3; pfam08291
266834009477	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
266834009478	DHH family; Region: DHH; pfam01368
266834009479	DHHA1 domain; Region: DHHA1; pfam02272
266834009480	homoserine dehydrogenase; Provisional; Region: PRK06349
266834009481	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
266834009482	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
266834009483	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
266834009484	aminotransferase; Validated; Region: PRK09148
266834009485	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834009486	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834009487	homodimer interface [polypeptide binding]; other site
266834009488	catalytic residue [active]
266834009489	Short C-terminal domain; Region: SHOCT; pfam09851
266834009490	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
266834009491	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
266834009492	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
266834009493	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
266834009494	active site
266834009495	hypothetical protein; Reviewed; Region: PRK00024
266834009496	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
266834009497	MPN+ (JAMM) motif; other site
266834009498	Zinc-binding site [ion binding]; other site
266834009499	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
266834009500	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
266834009501	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
266834009502	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834009503	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
266834009504	FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997
266834009505	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
266834009506	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
266834009507	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
266834009508	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
266834009509	catalytic residue [active]
266834009510	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
266834009511	FeS assembly protein SufD; Region: sufD; TIGR01981
266834009512	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
266834009513	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
266834009514	Walker A/P-loop; other site
266834009515	ATP binding site [chemical binding]; other site
266834009516	Q-loop/lid; other site
266834009517	ABC transporter signature motif; other site
266834009518	Walker B; other site
266834009519	D-loop; other site
266834009520	H-loop/switch region; other site
266834009521	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
266834009522	putative ABC transporter; Region: ycf24; CHL00085
266834009523	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
266834009524	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
266834009525	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
266834009526	catalytic residue [active]
266834009527	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
266834009528	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
266834009529	Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377
266834009530	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
266834009531	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
266834009532	active site
266834009533	HIGH motif; other site
266834009534	dimer interface [polypeptide binding]; other site
266834009535	KMSKS motif; other site
266834009536	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
266834009537	RNA binding surface [nucleotide binding]; other site
266834009538	Protein of unknown function; Region: DUF3971; pfam13116
266834009539	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
266834009540	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
266834009541	catalytic triad [active]
266834009542	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
266834009543	dinuclear metal binding motif [ion binding]; other site
266834009544	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2833
266834009545	dinuclear metal binding motif [ion binding]; other site
266834009546	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
266834009547	Peptidase family M23; Region: Peptidase_M23; pfam01551
266834009548	helicase 45; Provisional; Region: PTZ00424
266834009549	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
266834009550	ATP binding site [chemical binding]; other site
266834009551	Mg++ binding site [ion binding]; other site
266834009552	motif III; other site
266834009553	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
266834009554	nucleotide binding region [chemical binding]; other site
266834009555	ATP-binding site [chemical binding]; other site
266834009556	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_20; cd04679
266834009557	nudix motif; other site
266834009558	TfoX N-terminal domain; Region: TfoX_N; pfam04993
266834009559	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
266834009560	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
266834009561	putative MPT binding site; other site
266834009562	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
266834009563	Ligand binding site; other site
266834009564	metal-binding site
266834009565	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
266834009566	XdhC Rossmann domain; Region: XdhC_C; pfam13478
266834009567	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
266834009568	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
266834009569	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
266834009570	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
266834009571	metal ion-dependent adhesion site (MIDAS); other site
266834009572	MoxR-like ATPases [General function prediction only]; Region: COG0714
266834009573	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834009574	Walker A motif; other site
266834009575	ATP binding site [chemical binding]; other site
266834009576	Walker B motif; other site
266834009577	arginine finger; other site
266834009578	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
266834009579	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
266834009580	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
266834009581	ligand binding site [chemical binding]; other site
266834009582	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
266834009583	putative active site pocket [active]
266834009584	cleavage site
266834009585	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
266834009586	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
266834009587	substrate binding site [chemical binding]; other site
266834009588	hexamer interface [polypeptide binding]; other site
266834009589	metal binding site [ion binding]; metal-binding site
266834009590	Predicted secreted protein [Function unknown]; Region: COG5497
266834009591	DZF domain; Region: DZF; cl02675
266834009592	adenylosuccinate lyase; Provisional; Region: PRK07492
266834009593	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
266834009594	tetramer interface [polypeptide binding]; other site
266834009595	active site
266834009596	PilZ domain; Region: PilZ; cl01260
266834009597	Predicted integral membrane protein [Function unknown]; Region: COG5473
266834009598	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
266834009599	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
266834009600	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834009601	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834009602	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
266834009603	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834009604	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834009605	dimerization interface [polypeptide binding]; other site
266834009606	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
266834009607	hypothetical protein; Provisional; Region: PRK09262
266834009608	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
266834009609	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
266834009610	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
266834009611	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
266834009612	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
266834009613	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
266834009614	Uncharacterized conserved protein [Function unknown]; Region: COG5467
266834009615	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
266834009616	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
266834009617	ATP binding site [chemical binding]; other site
266834009618	active site
266834009619	substrate binding site [chemical binding]; other site
266834009620	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
266834009621	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
266834009622	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
266834009623	putative active site [active]
266834009624	catalytic triad [active]
266834009625	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
266834009626	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
266834009627	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834009628	DNA-binding site [nucleotide binding]; DNA binding site
266834009629	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834009630	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834009631	homodimer interface [polypeptide binding]; other site
266834009632	catalytic residue [active]
266834009633	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
266834009634	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
266834009635	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
266834009636	dimerization interface [polypeptide binding]; other site
266834009637	ATP binding site [chemical binding]; other site
266834009638	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
266834009639	dimerization interface [polypeptide binding]; other site
266834009640	ATP binding site [chemical binding]; other site
266834009641	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
266834009642	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
266834009643	putative GSH binding site [chemical binding]; other site
266834009644	catalytic residues [active]
266834009645	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
266834009646	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834009647	putative substrate translocation pore; other site
266834009648	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834009649	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
266834009650	putative substrate translocation pore; other site
266834009651	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
266834009652	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
266834009653	active site
266834009654	putative lithium-binding site [ion binding]; other site
266834009655	substrate binding site [chemical binding]; other site
266834009656	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
266834009657	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
266834009658	Ligand Binding Site [chemical binding]; other site
266834009659	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
266834009660	glutaminase; Provisional; Region: PRK00971
266834009661	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
266834009662	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
266834009663	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
266834009664	RNA binding surface [nucleotide binding]; other site
266834009665	Domain of unknown function DUF87; Region: DUF87; pfam01935
266834009666	HerA helicase [Replication, recombination, and repair]; Region: COG0433
266834009667	glutamate racemase; Provisional; Region: PRK00865
266834009668	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
266834009669	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
266834009670	Predicted membrane protein [Function unknown]; Region: COG1289
266834009671	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
266834009672	isocitrate dehydrogenase; Validated; Region: PRK08299
266834009673	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
266834009674	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834009675	Protein involved in beta-1,3-glucan synthesis [Carbohydrate transport and metabolism]; Region: SMI1; COG4282
266834009676	Uncharacterized conserved protein [Function unknown]; Region: COG5361
266834009677	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
266834009678	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
266834009679	Uncharacterized conserved protein [Function unknown]; Region: COG5361
266834009680	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
266834009681	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
266834009682	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
266834009683	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
266834009684	Sulfate transporter family; Region: Sulfate_transp; pfam00916
266834009685	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
266834009686	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
266834009687	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
266834009688	motif 1; other site
266834009689	active site
266834009690	motif 2; other site
266834009691	motif 3; other site
266834009692	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
266834009693	recombinase A; Provisional; Region: recA; PRK09354
266834009694	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
266834009695	hexamer interface [polypeptide binding]; other site
266834009696	Walker A motif; other site
266834009697	ATP binding site [chemical binding]; other site
266834009698	Walker B motif; other site
266834009699	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
266834009700	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
266834009701	substrate binding site [chemical binding]; other site
266834009702	ATP binding site [chemical binding]; other site
266834009703	Uncharacterized enzyme involved in pigment biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IndA; COG2313
266834009704	PAS domain; Region: PAS; smart00091
266834009705	PAS domain; Region: PAS_9; pfam13426
266834009706	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
266834009707	PAS domain; Region: PAS; smart00091
266834009708	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834009709	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834009710	dimer interface [polypeptide binding]; other site
266834009711	phosphorylation site [posttranslational modification]
266834009712	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834009713	ATP binding site [chemical binding]; other site
266834009714	Mg2+ binding site [ion binding]; other site
266834009715	G-X-G motif; other site
266834009716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834009717	Response regulator receiver domain; Region: Response_reg; pfam00072
266834009718	active site
266834009719	phosphorylation site [posttranslational modification]
266834009720	intermolecular recognition site; other site
266834009721	dimerization interface [polypeptide binding]; other site
266834009722	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
266834009723	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
266834009724	catalytic core [active]
266834009725	Predicted ATPase [General function prediction only]; Region: COG3106
266834009726	Predicted membrane protein [Function unknown]; Region: COG3768
266834009727	Domain of unknown function (DUF697); Region: DUF697; cl12064
266834009728	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
266834009729	catalytic center binding site [active]
266834009730	ATP binding site [chemical binding]; other site
266834009731	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
266834009732	homooctamer interface [polypeptide binding]; other site
266834009733	active site
266834009734	dihydropteroate synthase; Region: DHPS; TIGR01496
266834009735	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
266834009736	substrate binding pocket [chemical binding]; other site
266834009737	dimer interface [polypeptide binding]; other site
266834009738	inhibitor binding site; inhibition site
266834009739	Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661
266834009740	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
266834009741	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834009742	catalytic loop [active]
266834009743	iron binding site [ion binding]; other site
266834009744	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
266834009745	cytochrome b; Provisional; Region: CYTB; MTH00191
266834009746	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
266834009747	Qi binding site; other site
266834009748	intrachain domain interface; other site
266834009749	interchain domain interface [polypeptide binding]; other site
266834009750	heme bH binding site [chemical binding]; other site
266834009751	heme bL binding site [chemical binding]; other site
266834009752	Qo binding site; other site
266834009753	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
266834009754	interchain domain interface [polypeptide binding]; other site
266834009755	intrachain domain interface; other site
266834009756	Qi binding site; other site
266834009757	Qo binding site; other site
266834009758	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
266834009759	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
266834009760	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
266834009761	[2Fe-2S] cluster binding site [ion binding]; other site
266834009762	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
266834009763	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834009764	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
266834009765	Walker A/P-loop; other site
266834009766	ATP binding site [chemical binding]; other site
266834009767	Q-loop/lid; other site
266834009768	ABC transporter signature motif; other site
266834009769	Walker B; other site
266834009770	D-loop; other site
266834009771	H-loop/switch region; other site
266834009772	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
266834009773	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834009774	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834009775	Walker A/P-loop; other site
266834009776	ATP binding site [chemical binding]; other site
266834009777	Q-loop/lid; other site
266834009778	ABC transporter signature motif; other site
266834009779	Walker B; other site
266834009780	D-loop; other site
266834009781	H-loop/switch region; other site
266834009782	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
266834009783	Predicted flavoprotein [General function prediction only]; Region: COG0431
266834009784	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
266834009785	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
266834009786	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
266834009787	DNA binding residues [nucleotide binding]
266834009788	dimer interface [polypeptide binding]; other site
266834009789	[2Fe-2S] cluster binding site [ion binding]; other site
266834009790	Coproporphyrinogen III oxidase [Coenzyme metabolism]; Region: HemF; COG0408
266834009791	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
266834009792	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3657
266834009793	Predicted transcriptional regulator [Transcription]; Region: COG3636
266834009794	ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218
266834009795	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
266834009796	mce related protein; Region: MCE; pfam02470
266834009797	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
266834009798	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
266834009799	Walker A/P-loop; other site
266834009800	ATP binding site [chemical binding]; other site
266834009801	Q-loop/lid; other site
266834009802	ABC transporter signature motif; other site
266834009803	Walker B; other site
266834009804	D-loop; other site
266834009805	H-loop/switch region; other site
266834009806	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
266834009807	Permease; Region: Permease; pfam02405
266834009808	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
266834009809	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
266834009810	active site
266834009811	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834009812	putative substrate translocation pore; other site
266834009813	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
266834009814	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
266834009815	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
266834009816	putative active site [active]
266834009817	putative metal binding site [ion binding]; other site
266834009818	malic enzyme; Reviewed; Region: PRK12862
266834009819	Malic enzyme, N-terminal domain; Region: malic; pfam00390
266834009820	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
266834009821	putative NAD(P) binding site [chemical binding]; other site
266834009822	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
266834009823	Autoinducer binding domain; Region: Autoind_bind; pfam03472
266834009824	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834009825	DNA binding residues [nucleotide binding]
266834009826	dimerization interface [polypeptide binding]; other site
266834009827	N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916
266834009828	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
266834009829	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
266834009830	putative FMN binding site [chemical binding]; other site
266834009831	short chain dehydrogenase; Provisional; Region: PRK06198
266834009832	classical (c) SDRs; Region: SDR_c; cd05233
266834009833	NAD(P) binding site [chemical binding]; other site
266834009834	active site
266834009835	Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285
266834009836	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834009837	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834009838	DNA binding site [nucleotide binding]
266834009839	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
266834009840	putative ligand binding site [chemical binding]; other site
266834009841	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
266834009842	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
266834009843	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
266834009844	NAD synthetase; Provisional; Region: PRK13981
266834009845	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
266834009846	multimer interface [polypeptide binding]; other site
266834009847	active site
266834009848	catalytic triad [active]
266834009849	protein interface 1 [polypeptide binding]; other site
266834009850	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
266834009851	homodimer interface [polypeptide binding]; other site
266834009852	NAD binding pocket [chemical binding]; other site
266834009853	ATP binding pocket [chemical binding]; other site
266834009854	Mg binding site [ion binding]; other site
266834009855	active-site loop [active]
266834009856	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
266834009857	Sulfatase; Region: Sulfatase; pfam00884
266834009858	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
266834009859	TadE-like protein; Region: TadE; pfam07811
266834009860	Predicted membrane protein [Function unknown]; Region: COG4655
266834009861	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
266834009862	Uncharacterized conserved protein [Function unknown]; Region: COG3791
266834009863	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
266834009864	glutathione-disulfide reductase, plant; Region: gluta_reduc_2; TIGR01424
266834009865	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834009866	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
266834009867	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184
266834009868	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
266834009869	tetramer (dimer of dimers) interface [polypeptide binding]; other site
266834009870	active site
266834009871	dimer interface [polypeptide binding]; other site
266834009872	phosphoglycolate phosphatase; Provisional; Region: PRK13222
266834009873	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834009874	motif II; other site
266834009875	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
266834009876	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834009877	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
266834009878	fumarate hydratase; Reviewed; Region: fumC; PRK00485
266834009879	Class II fumarases; Region: Fumarase_classII; cd01362
266834009880	active site
266834009881	tetramer interface [polypeptide binding]; other site
266834009882	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
266834009883	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
266834009884	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
266834009885	Transcriptional regulators [Transcription]; Region: MarR; COG1846
266834009886	MarR family; Region: MarR_2; pfam12802
266834009887	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
266834009888	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
266834009889	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
266834009890	FeS/SAM binding site; other site
266834009891	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
266834009892	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
266834009893	EamA-like transporter family; Region: EamA; pfam00892
266834009894	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
266834009895	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
266834009896	GTP binding site; other site
266834009897	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
266834009898	Walker A motif; other site
266834009899	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
266834009900	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
266834009901	ligand binding site [chemical binding]; other site
266834009902	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
266834009903	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834009904	substrate binding pocket [chemical binding]; other site
266834009905	membrane-bound complex binding site; other site
266834009906	hinge residues; other site
266834009907	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834009908	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834009909	dimer interface [polypeptide binding]; other site
266834009910	conserved gate region; other site
266834009911	putative PBP binding loops; other site
266834009912	ABC-ATPase subunit interface; other site
266834009913	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834009914	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834009915	dimer interface [polypeptide binding]; other site
266834009916	conserved gate region; other site
266834009917	putative PBP binding loops; other site
266834009918	ABC-ATPase subunit interface; other site
266834009919	Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425
266834009920	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
266834009921	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
266834009922	putative NAD(P) binding site [chemical binding]; other site
266834009923	putative active site [active]
266834009924	Predicted integral membrane protein [Function unknown]; Region: COG5530
266834009925	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
266834009926	Tetratricopeptide repeat; Region: TPR_1; pfam00515
266834009927	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
266834009928	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
266834009929	NAD(P) binding pocket [chemical binding]; other site
266834009930	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
266834009931	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
266834009932	A new structural DNA glycosylase; Region: AlkD_like; cd06561
266834009933	active site
266834009934	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834009935	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834009936	putative DNA binding site [nucleotide binding]; other site
266834009937	putative Zn2+ binding site [ion binding]; other site
266834009938	AsnC family; Region: AsnC_trans_reg; pfam01037
266834009939	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
266834009940	putative uracil binding site [chemical binding]; other site
266834009941	putative active site [active]
266834009942	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
266834009943	Catalytic site; other site
266834009944	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
266834009945	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834009946	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834009947	dimer interface [polypeptide binding]; other site
266834009948	phosphorylation site [posttranslational modification]
266834009949	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834009950	ATP binding site [chemical binding]; other site
266834009951	Mg2+ binding site [ion binding]; other site
266834009952	G-X-G motif; other site
266834009953	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
266834009954	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
266834009955	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
266834009956	putative dimer interface [polypeptide binding]; other site
266834009957	active site pocket [active]
266834009958	putative cataytic base [active]
266834009959	cobalamin synthase; Reviewed; Region: cobS; PRK00235
266834009960	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
266834009961	Predicted aspartyl protease [General function prediction only]; Region: COG3577
266834009962	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
266834009963	catalytic motif [active]
266834009964	Catalytic residue [active]
266834009965	ABC-2 type transporter; Region: ABC2_membrane; cl17235
266834009966	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
266834009967	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
266834009968	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
266834009969	Walker A/P-loop; other site
266834009970	ATP binding site [chemical binding]; other site
266834009971	Q-loop/lid; other site
266834009972	ABC transporter signature motif; other site
266834009973	Walker B; other site
266834009974	D-loop; other site
266834009975	H-loop/switch region; other site
266834009976	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834009977	dimerization interface [polypeptide binding]; other site
266834009978	putative DNA binding site [nucleotide binding]; other site
266834009979	putative Zn2+ binding site [ion binding]; other site
266834009980	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
266834009981	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834009982	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
266834009983	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
266834009984	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
266834009985	Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097
266834009986	Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097
266834009987	Cache domain; Region: Cache_2; pfam08269
266834009988	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
266834009989	dimerization interface [polypeptide binding]; other site
266834009990	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
266834009991	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
266834009992	dimer interface [polypeptide binding]; other site
266834009993	putative CheW interface [polypeptide binding]; other site
266834009994	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
266834009995	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169
266834009996	excinuclease ABC subunit B; Provisional; Region: PRK05298
266834009997	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
266834009998	ATP binding site [chemical binding]; other site
266834009999	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
266834010000	nucleotide binding region [chemical binding]; other site
266834010001	ATP-binding site [chemical binding]; other site
266834010002	Ultra-violet resistance protein B; Region: UvrB; pfam12344
266834010003	UvrB/uvrC motif; Region: UVR; pfam02151
266834010004	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
266834010005	HSP70 interaction site [polypeptide binding]; other site
266834010006	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
266834010007	DNA-binding site [nucleotide binding]; DNA binding site
266834010008	RNA-binding motif; other site
266834010009	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
266834010010	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
266834010011	FMN binding site [chemical binding]; other site
266834010012	active site
266834010013	catalytic residues [active]
266834010014	substrate binding site [chemical binding]; other site
266834010015	Protein of unknown function (DUF982); Region: DUF982; pfam06169
266834010016	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
266834010017	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
266834010018	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
266834010019	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
266834010020	trimer interface [polypeptide binding]; other site
266834010021	putative metal binding site [ion binding]; other site
266834010022	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
266834010023	metal binding site 2 [ion binding]; metal-binding site
266834010024	putative DNA binding helix; other site
266834010025	metal binding site 1 [ion binding]; metal-binding site
266834010026	dimer interface [polypeptide binding]; other site
266834010027	structural Zn2+ binding site [ion binding]; other site
266834010028	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
266834010029	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
266834010030	ABC-ATPase subunit  interface; other site
266834010031	dimer interface [polypeptide binding]; other site
266834010032	putative PBP binding regions; other site
266834010033	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
266834010034	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
266834010035	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
266834010036	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
266834010037	metal binding site [ion binding]; metal-binding site
266834010038	Predicted integral membrane protein [Function unknown]; Region: COG5455
266834010039	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
266834010040	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
266834010041	inhibitor binding site; inhibition site
266834010042	active site
266834010043	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
266834010044	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
266834010045	DctM-like transporters; Region: DctM; pfam06808
266834010046	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
266834010047	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834010048	Winged helix-turn helix; Region: HTH_29; pfam13551
266834010049	Homeodomain-like domain; Region: HTH_32; pfam13565
266834010050	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
266834010051	Integrase core domain; Region: rve; pfam00665
266834010052	Integrase core domain; Region: rve_3; pfam13683
266834010053	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
266834010054	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
266834010055	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834010056	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834010057	active site
266834010058	catalytic tetrad [active]
266834010059	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834010060	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834010061	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
266834010062	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
266834010063	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
266834010064	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
266834010065	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
266834010066	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
266834010067	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834010068	Walker A/P-loop; other site
266834010069	ATP binding site [chemical binding]; other site
266834010070	Q-loop/lid; other site
266834010071	ABC transporter signature motif; other site
266834010072	Walker B; other site
266834010073	D-loop; other site
266834010074	H-loop/switch region; other site
266834010075	TOBE domain; Region: TOBE; pfam03459
266834010076	TOBE domain; Region: TOBE_2; pfam08402
266834010077	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834010078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834010079	dimer interface [polypeptide binding]; other site
266834010080	conserved gate region; other site
266834010081	putative PBP binding loops; other site
266834010082	ABC-ATPase subunit interface; other site
266834010083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834010084	dimer interface [polypeptide binding]; other site
266834010085	conserved gate region; other site
266834010086	putative PBP binding loops; other site
266834010087	ABC-ATPase subunit interface; other site
266834010088	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834010089	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834010090	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834010091	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834010092	DNA binding site [nucleotide binding]
266834010093	domain linker motif; other site
266834010094	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
266834010095	ligand binding site [chemical binding]; other site
266834010096	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
266834010097	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
266834010098	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
266834010099	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
266834010100	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
266834010101	Helix-turn-helix domain; Region: HTH_18; pfam12833
266834010102	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
266834010103	hydrophobic ligand binding site; other site
266834010104	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834010105	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
266834010106	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
266834010107	putative acyl-acceptor binding pocket; other site
266834010108	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
266834010109	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
266834010110	putative NAD(P) binding site [chemical binding]; other site
266834010111	structural Zn binding site [ion binding]; other site
266834010112	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
266834010113	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
266834010114	dimer interface [polypeptide binding]; other site
266834010115	active site
266834010116	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
266834010117	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
266834010118	active site
266834010119	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764
266834010120	active site 2 [active]
266834010121	active site 1 [active]
266834010122	acyl carrier protein; Provisional; Region: PRK06508
266834010123	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
266834010124	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
266834010125	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834010126	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834010127	homodimer interface [polypeptide binding]; other site
266834010128	catalytic residue [active]
266834010129	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
266834010130	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
266834010131	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
266834010132	active site
266834010133	SAM binding site [chemical binding]; other site
266834010134	homodimer interface [polypeptide binding]; other site
266834010135	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
266834010136	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
266834010137	hypothetical protein; Provisional; Region: PRK10621
266834010138	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
266834010139	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
266834010140	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834010141	Walker A/P-loop; other site
266834010142	ATP binding site [chemical binding]; other site
266834010143	Q-loop/lid; other site
266834010144	ABC transporter signature motif; other site
266834010145	Walker B; other site
266834010146	D-loop; other site
266834010147	H-loop/switch region; other site
266834010148	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834010149	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834010150	Walker A/P-loop; other site
266834010151	ATP binding site [chemical binding]; other site
266834010152	Q-loop/lid; other site
266834010153	ABC transporter signature motif; other site
266834010154	Walker B; other site
266834010155	D-loop; other site
266834010156	H-loop/switch region; other site
266834010157	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
266834010158	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
266834010159	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834010160	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
266834010161	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834010162	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834010163	dimer interface [polypeptide binding]; other site
266834010164	conserved gate region; other site
266834010165	putative PBP binding loops; other site
266834010166	ABC-ATPase subunit interface; other site
266834010167	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
266834010168	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834010169	dimer interface [polypeptide binding]; other site
266834010170	conserved gate region; other site
266834010171	putative PBP binding loops; other site
266834010172	ABC-ATPase subunit interface; other site
266834010173	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
266834010174	ANTAR domain; Region: ANTAR; pfam03861
266834010175	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
266834010176	Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357
266834010177	ligand binding site [chemical binding]; other site
266834010178	regulator interaction site; other site
266834010179	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
266834010180	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
266834010181	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
266834010182	homodimer interface [polypeptide binding]; other site
266834010183	Walker A motif; other site
266834010184	ATP binding site [chemical binding]; other site
266834010185	hydroxycobalamin binding site [chemical binding]; other site
266834010186	Walker B motif; other site
266834010187	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
266834010188	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
266834010189	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
266834010190	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
266834010191	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
266834010192	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
266834010193	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
266834010194	homotrimer interface [polypeptide binding]; other site
266834010195	Walker A motif; other site
266834010196	GTP binding site [chemical binding]; other site
266834010197	Walker B motif; other site
266834010198	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
266834010199	FecR protein; Region: FecR; pfam04773
266834010200	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
266834010201	CHASE2 domain; Region: CHASE2; pfam05226
266834010202	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834010203	cyclase homology domain; Region: CHD; cd07302
266834010204	nucleotidyl binding site; other site
266834010205	metal binding site [ion binding]; metal-binding site
266834010206	dimer interface [polypeptide binding]; other site
266834010207	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
266834010208	cobyric acid synthase; Provisional; Region: PRK00784
266834010209	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
266834010210	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
266834010211	catalytic triad [active]
266834010212	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
266834010213	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
266834010214	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
266834010215	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834010216	Walker A/P-loop; other site
266834010217	ATP binding site [chemical binding]; other site
266834010218	Q-loop/lid; other site
266834010219	ABC transporter signature motif; other site
266834010220	Walker B; other site
266834010221	D-loop; other site
266834010222	H-loop/switch region; other site
266834010223	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
266834010224	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
266834010225	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
266834010226	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834010227	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834010228	dimerization interface [polypeptide binding]; other site
266834010229	methionine synthase I; Validated; Region: PRK07534
266834010230	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
266834010231	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
266834010232	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834010233	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834010234	homodimer interface [polypeptide binding]; other site
266834010235	catalytic residue [active]
266834010236	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
266834010237	YheO-like PAS domain; Region: PAS_6; pfam08348
266834010238	HTH domain; Region: HTH_22; pfam13309
266834010239	Predicted periplasmic protein [Function unknown]; Region: COG3698
266834010240	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
266834010241	Ferredoxin [Energy production and conversion]; Region: NapF; COG1145
266834010242	Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253
266834010243	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
266834010244	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
266834010245	B12 binding site [chemical binding]; other site
266834010246	cobalt ligand [ion binding]; other site
266834010247	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
266834010248	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
266834010249	Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653
266834010250	putative active site [active]
266834010251	putative cosubstrate binding site; other site
266834010252	putative substrate binding site [chemical binding]; other site
266834010253	catalytic site [active]
266834010254	BA14K-like protein; Region: BA14K; pfam07886
266834010255	Virulence factor; Region: Virulence_fact; pfam13769
266834010256	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
266834010257	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
266834010258	FAD binding site [chemical binding]; other site
266834010259	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
266834010260	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
266834010261	substrate binding pocket [chemical binding]; other site
266834010262	dimer interface [polypeptide binding]; other site
266834010263	inhibitor binding site; inhibition site
266834010264	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
266834010265	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834010266	catalytic loop [active]
266834010267	iron binding site [ion binding]; other site
266834010268	Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227
266834010269	AAA domain; Region: AAA_33; pfam13671
266834010270	P-loop motif; other site
266834010271	ATP binding site [chemical binding]; other site
266834010272	Chloramphenicol (Cm) binding site [chemical binding]; other site
266834010273	catalytic residue [active]
266834010274	Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891
266834010275	putative hydrophobic ligand binding site [chemical binding]; other site
266834010276	CLM binding site; other site
266834010277	L1 loop; other site
266834010278	DNA binding site [nucleotide binding]
266834010279	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834010280	dimerization interface [polypeptide binding]; other site
266834010281	putative DNA binding site [nucleotide binding]; other site
266834010282	putative Zn2+ binding site [ion binding]; other site
266834010283	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834010284	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834010285	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834010286	dimerization interface [polypeptide binding]; other site
266834010287	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
266834010288	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
266834010289	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
266834010290	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
266834010291	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
266834010292	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
266834010293	putative metal binding site [ion binding]; other site
266834010294	putative homodimer interface [polypeptide binding]; other site
266834010295	putative homotetramer interface [polypeptide binding]; other site
266834010296	putative homodimer-homodimer interface [polypeptide binding]; other site
266834010297	putative allosteric switch controlling residues; other site
266834010298	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
266834010299	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
266834010300	conserved cys residue [active]
266834010301	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834010302	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
266834010303	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834010304	active site
266834010305	phosphorylation site [posttranslational modification]
266834010306	intermolecular recognition site; other site
266834010307	dimerization interface [polypeptide binding]; other site
266834010308	Response regulator receiver domain; Region: Response_reg; pfam00072
266834010309	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834010310	active site
266834010311	phosphorylation site [posttranslational modification]
266834010312	intermolecular recognition site; other site
266834010313	dimerization interface [polypeptide binding]; other site
266834010314	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
266834010315	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834010316	cyclase homology domain; Region: CHD; cd07302
266834010317	nucleotidyl binding site; other site
266834010318	metal binding site [ion binding]; metal-binding site
266834010319	dimer interface [polypeptide binding]; other site
266834010320	RibD C-terminal domain; Region: RibD_C; cl17279
266834010321	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
266834010322	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
266834010323	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
266834010324	Mechanosensitive ion channel; Region: MS_channel; pfam00924
266834010325	Uncharacterized conserved protein [Function unknown]; Region: COG3791
266834010326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803
266834010327	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
266834010328	transmembrane helices; other site
266834010329	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
266834010330	TrkA-C domain; Region: TrkA_C; pfam02080
266834010331	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
266834010332	Protein of unknown function (DUF1515); Region: DUF1515; pfam07439
266834010333	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
266834010334	catalytic residue [active]
266834010335	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
266834010336	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
266834010337	active site
266834010338	Terminase-like family; Region: Terminase_6; pfam03237
266834010339	Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565
266834010340	Uncharacterized conserved protein [Function unknown]; Region: COG3791
266834010341	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834010342	MULE transposase domain; Region: MULE; pfam10551
266834010343	BA14K-like protein; Region: BA14K; pfam07886
266834010344	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
266834010345	DnaA box-binding interface [nucleotide binding]; other site
266834010346	Predicted transcriptional regulator [Transcription]; Region: COG2932
266834010347	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834010348	non-specific DNA binding site [nucleotide binding]; other site
266834010349	salt bridge; other site
266834010350	sequence-specific DNA binding site [nucleotide binding]; other site
266834010351	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
266834010352	Catalytic site [active]
266834010353	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
266834010354	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
266834010355	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
266834010356	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
266834010357	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
266834010358	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
266834010359	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834010360	DNA binding residues [nucleotide binding]
266834010361	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
266834010362	FecR protein; Region: FecR; pfam04773
266834010363	Secretin and TonB N terminus short domain; Region: STN; smart00965
266834010364	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
266834010365	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
266834010366	N-terminal plug; other site
266834010367	ligand-binding site [chemical binding]; other site
266834010368	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
266834010369	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834010370	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
266834010371	Walker A/P-loop; other site
266834010372	ATP binding site [chemical binding]; other site
266834010373	Q-loop/lid; other site
266834010374	ABC transporter signature motif; other site
266834010375	Walker B; other site
266834010376	D-loop; other site
266834010377	H-loop/switch region; other site
266834010378	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
266834010379	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834010380	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
266834010381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424
266834010382	Predicted RNA binding protein (dsRBD-like fold), HicA family    [General function prediction only]; Region: COG1724
266834010383	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
266834010384	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
266834010385	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
266834010386	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
266834010387	nudix motif; other site
266834010388	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
266834010389	putative catalytic site [active]
266834010390	putative phosphate binding site [ion binding]; other site
266834010391	putative metal binding site [ion binding]; other site
266834010392	TIGR02594 family protein; Region: TIGR02594
266834010393	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
266834010394	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
266834010395	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
266834010396	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
266834010397	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
266834010398	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
266834010399	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834010400	cyclase homology domain; Region: CHD; cd07302
266834010401	nucleotidyl binding site; other site
266834010402	metal binding site [ion binding]; metal-binding site
266834010403	dimer interface [polypeptide binding]; other site
266834010404	Predicted integral membrane protein [Function unknown]; Region: COG5616
266834010405	TPR repeat; Region: TPR_11; pfam13414
266834010406	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834010407	binding surface
266834010408	TPR motif; other site
266834010409	cell division protein FtsZ; Provisional; Region: PRK13018
266834010410	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
266834010411	nucleotide binding site [chemical binding]; other site
266834010412	SulA interaction site; other site
266834010413	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
266834010414	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834010415	active site
266834010416	motif I; other site
266834010417	motif II; other site
266834010418	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
266834010419	AAA ATPase domain; Region: AAA_16; pfam13191
266834010420	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
266834010421	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
266834010422	Walker A/P-loop; other site
266834010423	ATP binding site [chemical binding]; other site
266834010424	Q-loop/lid; other site
266834010425	ABC transporter signature motif; other site
266834010426	Walker B; other site
266834010427	D-loop; other site
266834010428	H-loop/switch region; other site
266834010429	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
266834010430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834010431	dimer interface [polypeptide binding]; other site
266834010432	conserved gate region; other site
266834010433	putative PBP binding loops; other site
266834010434	ABC-ATPase subunit interface; other site
266834010435	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
266834010436	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
266834010437	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
266834010438	DNA-binding site [nucleotide binding]; DNA binding site
266834010439	RNA-binding motif; other site
266834010440	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
266834010441	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834010442	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
266834010443	C-terminal domain interface [polypeptide binding]; other site
266834010444	GSH binding site (G-site) [chemical binding]; other site
266834010445	dimer interface [polypeptide binding]; other site
266834010446	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
266834010447	N-terminal domain interface [polypeptide binding]; other site
266834010448	dimer interface [polypeptide binding]; other site
266834010449	substrate binding pocket (H-site) [chemical binding]; other site
266834010450	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834010451	active site
266834010452	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834010453	catalytic tetrad [active]
266834010454	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
266834010455	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834010456	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834010457	homodimer interface [polypeptide binding]; other site
266834010458	catalytic residue [active]
266834010459	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
266834010460	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
266834010461	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
266834010462	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
266834010463	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834010464	cyclase homology domain; Region: CHD; cd07302
266834010465	nucleotidyl binding site; other site
266834010466	metal binding site [ion binding]; metal-binding site
266834010467	dimer interface [polypeptide binding]; other site
266834010468	ketol-acid reductoisomerase; Provisional; Region: PRK05479
266834010469	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
266834010470	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
266834010471	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834010472	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834010473	macrolide transporter subunit MacA; Provisional; Region: PRK11578
266834010474	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834010475	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
266834010476	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
266834010477	Walker A/P-loop; other site
266834010478	ATP binding site [chemical binding]; other site
266834010479	Q-loop/lid; other site
266834010480	ABC transporter signature motif; other site
266834010481	Walker B; other site
266834010482	D-loop; other site
266834010483	H-loop/switch region; other site
266834010484	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
266834010485	FtsX-like permease family; Region: FtsX; pfam02687
266834010486	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
266834010487	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
266834010488	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
266834010489	Catalytic site; other site
266834010490	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
266834010491	Phosphotransferase enzyme family; Region: APH; pfam01636
266834010492	putative active site [active]
266834010493	putative substrate binding site [chemical binding]; other site
266834010494	ATP binding site [chemical binding]; other site
266834010495	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
266834010496	benzoate transport; Region: 2A0115; TIGR00895
266834010497	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834010498	putative substrate translocation pore; other site
266834010499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834010500	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
266834010501	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
266834010502	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
266834010503	putative active site [active]
266834010504	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
266834010505	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834010506	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834010507	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834010508	putative DNA binding site [nucleotide binding]; other site
266834010509	putative Zn2+ binding site [ion binding]; other site
266834010510	AsnC family; Region: AsnC_trans_reg; pfam01037
266834010511	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
266834010512	aspartate racemase; Region: asp_race; TIGR00035
266834010513	Predicted transcriptional regulators [Transcription]; Region: COG1733
266834010514	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
266834010515	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
266834010516	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834010517	NAD(P) binding site [chemical binding]; other site
266834010518	active site
266834010519	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
266834010520	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
266834010521	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834010522	DNA-binding site [nucleotide binding]; DNA binding site
266834010523	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834010524	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834010525	homodimer interface [polypeptide binding]; other site
266834010526	catalytic residue [active]
266834010527	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
266834010528	active site
266834010529	hydrophilic channel; other site
266834010530	dimerization interface [polypeptide binding]; other site
266834010531	catalytic residues [active]
266834010532	active site lid [active]
266834010533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312
266834010534	EF-hand domain pair; Region: EF_hand_5; pfam13499
266834010535	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
266834010536	Ca2+ binding site [ion binding]; other site
266834010537	Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598
266834010538	Zn binding site [ion binding]; other site
266834010539	Uncharacterized conserved protein [Function unknown]; Region: COG3482
266834010540	YcaO-like family; Region: YcaO; pfam02624
266834010541	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
266834010542	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
266834010543	cyclase homology domain; Region: CHD; cd07302
266834010544	nucleotidyl binding site; other site
266834010545	metal binding site [ion binding]; metal-binding site
266834010546	dimer interface [polypeptide binding]; other site
266834010547	Predicted ATPase [General function prediction only]; Region: COG3899
266834010548	AAA ATPase domain; Region: AAA_16; pfam13191
266834010549	Predicted ATPase [General function prediction only]; Region: COG3903
266834010550	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
266834010551	AAA domain; Region: AAA_30; pfam13604
266834010552	Family description; Region: UvrD_C_2; pfam13538
266834010553	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
266834010554	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
266834010555	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
266834010556	Predicted transcriptional regulator [Transcription]; Region: COG4190
266834010557	Helix-turn-helix domain; Region: HTH_20; pfam12840
266834010558	putative DNA binding site [nucleotide binding]; other site
266834010559	putative Zn2+ binding site [ion binding]; other site
266834010560	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315
266834010561	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
266834010562	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
266834010563	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
266834010564	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
266834010565	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834010566	DNA binding residues [nucleotide binding]
266834010567	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
266834010568	Putative zinc-finger; Region: zf-HC2; pfam13490
266834010569	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
266834010570	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
266834010571	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
266834010572	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
266834010573	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
266834010574	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
266834010575	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
266834010576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834010577	S-adenosylmethionine binding site [chemical binding]; other site
266834010578	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
266834010579	DNA-binding site [nucleotide binding]; DNA binding site
266834010580	RNA-binding motif; other site
266834010581	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834010582	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834010583	active site
266834010584	catalytic tetrad [active]
266834010585	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
266834010586	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
266834010587	putative valine binding site [chemical binding]; other site
266834010588	dimer interface [polypeptide binding]; other site
266834010589	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
266834010590	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
266834010591	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
266834010592	PYR/PP interface [polypeptide binding]; other site
266834010593	dimer interface [polypeptide binding]; other site
266834010594	TPP binding site [chemical binding]; other site
266834010595	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
266834010596	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
266834010597	TPP-binding site [chemical binding]; other site
266834010598	dimer interface [polypeptide binding]; other site
266834010599	HAS barrel domain; Region: HAS-barrel; pfam09378
266834010600	HerA helicase [Replication, recombination, and repair]; Region: COG0433
266834010601	Domain of unknown function DUF87; Region: DUF87; pfam01935
266834010602	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
266834010603	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
266834010604	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
266834010605	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
266834010606	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834010607	motif II; other site
266834010608	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
266834010609	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
266834010610	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
266834010611	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
266834010612	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
266834010613	protein binding site [polypeptide binding]; other site
266834010614	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
266834010615	protein binding site [polypeptide binding]; other site
266834010616	Uncharacterized conserved protein [Function unknown]; Region: COG3603
266834010617	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
266834010618	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
266834010619	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
266834010620	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
266834010621	HflK protein; Region: hflK; TIGR01933
266834010622	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
266834010623	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
266834010624	folate binding site [chemical binding]; other site
266834010625	NADP+ binding site [chemical binding]; other site
266834010626	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834010627	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
266834010628	putative C-terminal domain interface [polypeptide binding]; other site
266834010629	putative GSH binding site (G-site) [chemical binding]; other site
266834010630	putative dimer interface [polypeptide binding]; other site
266834010631	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
266834010632	dimer interface [polypeptide binding]; other site
266834010633	N-terminal domain interface [polypeptide binding]; other site
266834010634	putative substrate binding pocket (H-site) [chemical binding]; other site
266834010635	thymidylate synthase; Reviewed; Region: thyA; PRK01827
266834010636	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
266834010637	dimerization interface [polypeptide binding]; other site
266834010638	active site
266834010639	Uncharacterized conserved protein [Function unknown]; Region: COG5502
266834010640	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
266834010641	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
266834010642	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
266834010643	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
266834010644	Sm-1 OR SMc04491; FRAGMENT OF REPEAT SM-1, RELATED TO SMC04490 (FRAG SM-1) AND IS SMC04473 WHICH IS INSERTED IN THE REPEAT REGION; predicted by Homology
266834010645	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
266834010646	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
266834010647	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
266834010648	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
266834010649	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
266834010650	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
266834010651	FAD binding domain; Region: FAD_binding_4; pfam01565
266834010652	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
266834010653	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
266834010654	Protein export membrane protein; Region: SecD_SecF; cl14618
266834010655	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
266834010656	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834010657	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834010658	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
266834010659	Uncharacterized conserved protein [Function unknown]; Region: COG2128
266834010660	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
266834010661	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
266834010662	Part of AAA domain; Region: AAA_19; pfam13245
266834010663	Family description; Region: UvrD_C_2; pfam13538
266834010664	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
266834010665	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834010666	Coenzyme A binding pocket [chemical binding]; other site
266834010667	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926
266834010668	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
266834010669	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834010670	metal binding site [ion binding]; metal-binding site
266834010671	active site
266834010672	I-site; other site
266834010673	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
266834010674	CreA protein; Region: CreA; pfam05981
266834010675	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236
266834010676	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
266834010677	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
266834010678	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
266834010679	Transposase [DNA replication, recombination, and repair]; Region: COG5433
266834010680	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
266834010681	putative CheA interaction surface; other site
266834010682	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
266834010683	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
266834010684	dimer interface [polypeptide binding]; other site
266834010685	putative CheW interface [polypeptide binding]; other site
266834010686	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
266834010687	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
266834010688	Cu(I) binding site [ion binding]; other site
266834010689	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
266834010690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834010691	S-adenosylmethionine binding site [chemical binding]; other site
266834010692	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
266834010693	catalytic nucleophile [active]
266834010694	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
266834010695	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
266834010696	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
266834010697	active site
266834010698	Nuclear pore component; Region: Nup88; pfam10168
266834010699	Predicted membrane protein [Function unknown]; Region: COG4541
266834010700	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
266834010701	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
266834010702	oligomerization interface [polypeptide binding]; other site
266834010703	active site
266834010704	metal binding site [ion binding]; metal-binding site
266834010705	pantoate--beta-alanine ligase; Region: panC; TIGR00018
266834010706	Pantoate-beta-alanine ligase; Region: PanC; cd00560
266834010707	active site
266834010708	ATP-binding site [chemical binding]; other site
266834010709	pantoate-binding site; other site
266834010710	HXXH motif; other site
266834010711	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
266834010712	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834010713	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
266834010714	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
266834010715	nucleotide binding pocket [chemical binding]; other site
266834010716	K-X-D-G motif; other site
266834010717	catalytic site [active]
266834010718	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
266834010719	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
266834010720	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
266834010721	Dimer interface [polypeptide binding]; other site
266834010722	BRCT sequence motif; other site
266834010723	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
266834010724	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
266834010725	Walker A/P-loop; other site
266834010726	ATP binding site [chemical binding]; other site
266834010727	Q-loop/lid; other site
266834010728	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
266834010729	ABC transporter signature motif; other site
266834010730	Walker B; other site
266834010731	D-loop; other site
266834010732	H-loop/switch region; other site
266834010733	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
266834010734	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774
266834010735	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
266834010736	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
266834010737	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
266834010738	nucleotide binding site [chemical binding]; other site
266834010739	SulA interaction site; other site
266834010740	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
266834010741	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
266834010742	Cell division protein FtsA; Region: FtsA; smart00842
266834010743	Cell division protein FtsA; Region: FtsA; pfam14450
266834010744	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
266834010745	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
266834010746	Cell division protein FtsQ; Region: FtsQ; pfam03799
266834010747	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
266834010748	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
266834010749	ATP-grasp domain; Region: ATP-grasp_4; cl17255
266834010750	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
266834010751	amphipathic channel; other site
266834010752	Asn-Pro-Ala signature motifs; other site
266834010753	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834010754	metabolite-proton symporter; Region: 2A0106; TIGR00883
266834010755	putative substrate translocation pore; other site
266834010756	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
266834010757	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
266834010758	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
266834010759	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
266834010760	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
266834010761	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
266834010762	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
266834010763	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
266834010764	homodimer interface [polypeptide binding]; other site
266834010765	active site
266834010766	cell division protein FtsW; Region: ftsW; TIGR02614
266834010767	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
266834010768	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
266834010769	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
266834010770	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
266834010771	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
266834010772	Mg++ binding site [ion binding]; other site
266834010773	putative catalytic motif [active]
266834010774	putative substrate binding site [chemical binding]; other site
266834010775	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
266834010776	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
266834010777	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
266834010778	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
266834010779	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
266834010780	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
266834010781	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
266834010782	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
266834010783	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
266834010784	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
266834010785	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
266834010786	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
266834010787	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
266834010788	MraW methylase family; Region: Methyltransf_5; cl17771
266834010789	cell division protein MraZ; Reviewed; Region: PRK00326
266834010790	MraZ protein; Region: MraZ; pfam02381
266834010791	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834010792	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
266834010793	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
266834010794	N-acetyl-D-glucosamine binding site [chemical binding]; other site
266834010795	catalytic residue [active]
266834010796	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
266834010797	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
266834010798	amidase catalytic site [active]
266834010799	Zn binding residues [ion binding]; other site
266834010800	substrate binding site [chemical binding]; other site
266834010801	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834010802	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
266834010803	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
266834010804	putative metal binding site [ion binding]; other site
266834010805	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
266834010806	HSP70 interaction site [polypeptide binding]; other site
266834010807	pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555
266834010808	6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205
266834010809	active site
266834010810	ADP/pyrophosphate binding site [chemical binding]; other site
266834010811	allosteric effector site; other site
266834010812	dimerization interface [polypeptide binding]; other site
266834010813	fructose-1,6-bisphosphate binding site; other site
266834010814	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
266834010815	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
266834010816	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
266834010817	N-acetyl-D-glucosamine binding site [chemical binding]; other site
266834010818	catalytic residue [active]
266834010819	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
266834010820	Beta-lactamase; Region: Beta-lactamase; pfam00144
266834010821	S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379
266834010822	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834010823	S-adenosylmethionine binding site [chemical binding]; other site
266834010824	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
266834010825	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
266834010826	active site
266834010827	lytic murein transglycosylase; Region: MltB_2; TIGR02283
266834010828	murein hydrolase B; Provisional; Region: PRK10760; cl17906
266834010829	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834010830	EamA-like transporter family; Region: EamA; cl17759
266834010831	EamA-like transporter family; Region: EamA; pfam00892
266834010832	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
266834010833	FAD binding site [chemical binding]; other site
266834010834	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834010835	dimerization interface [polypeptide binding]; other site
266834010836	putative DNA binding site [nucleotide binding]; other site
266834010837	putative Zn2+ binding site [ion binding]; other site
266834010838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834010839	S-adenosylmethionine binding site [chemical binding]; other site
266834010840	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
266834010841	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834010842	Walker A/P-loop; other site
266834010843	ATP binding site [chemical binding]; other site
266834010844	Q-loop/lid; other site
266834010845	ABC transporter signature motif; other site
266834010846	Walker B; other site
266834010847	D-loop; other site
266834010848	H-loop/switch region; other site
266834010849	ABC transporter; Region: ABC_tran_2; pfam12848
266834010850	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
266834010851	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
266834010852	B1 nucleotide binding pocket [chemical binding]; other site
266834010853	B2 nucleotide binding pocket [chemical binding]; other site
266834010854	CAS motifs; other site
266834010855	active site
266834010856	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
266834010857	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
266834010858	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
266834010859	EamA-like transporter family; Region: EamA; pfam00892
266834010860	thiamine pyrophosphate protein; Validated; Region: PRK08199
266834010861	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
266834010862	PYR/PP interface [polypeptide binding]; other site
266834010863	dimer interface [polypeptide binding]; other site
266834010864	TPP binding site [chemical binding]; other site
266834010865	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
266834010866	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
266834010867	TPP-binding site [chemical binding]; other site
266834010868	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453
266834010869	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
266834010870	active site
266834010871	catalytic residues [active]
266834010872	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834010873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
266834010874	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
266834010875	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
266834010876	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834010877	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
266834010878	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
266834010879	P-loop; other site
266834010880	Magnesium ion binding site [ion binding]; other site
266834010881	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
266834010882	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
266834010883	putative active site [active]
266834010884	metal binding site [ion binding]; metal-binding site
266834010885	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
266834010886	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
266834010887	NAD(P) binding site [chemical binding]; other site
266834010888	catalytic residues [active]
266834010889	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
266834010890	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
266834010891	amino acid permease (GABA permease); Region: 2A0304; TIGR00907
266834010892	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
266834010893	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
266834010894	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
266834010895	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
266834010896	putative active site [active]
266834010897	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
266834010898	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
266834010899	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834010900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834010901	dimer interface [polypeptide binding]; other site
266834010902	conserved gate region; other site
266834010903	putative PBP binding loops; other site
266834010904	ABC-ATPase subunit interface; other site
266834010905	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834010906	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834010907	dimer interface [polypeptide binding]; other site
266834010908	conserved gate region; other site
266834010909	putative PBP binding loops; other site
266834010910	ABC-ATPase subunit interface; other site
266834010911	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
266834010912	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834010913	Walker A/P-loop; other site
266834010914	ATP binding site [chemical binding]; other site
266834010915	Q-loop/lid; other site
266834010916	ABC transporter signature motif; other site
266834010917	Walker B; other site
266834010918	D-loop; other site
266834010919	H-loop/switch region; other site
266834010920	TOBE domain; Region: TOBE_2; pfam08402
266834010921	riboflavin synthase subunit beta; Provisional; Region: PRK12419
266834010922	active site
266834010923	homopentamer interface [polypeptide binding]; other site
266834010924	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
266834010925	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834010926	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834010927	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
266834010928	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
266834010929	N-terminal plug; other site
266834010930	ligand-binding site [chemical binding]; other site
266834010931	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834010932	MULE transposase domain; Region: MULE; pfam10551
266834010933	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
266834010934	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
266834010935	substrate binding site [chemical binding]; other site
266834010936	dimer interface [polypeptide binding]; other site
266834010937	triosephosphate isomerase; Provisional; Region: PRK14565
266834010938	catalytic triad [active]
266834010939	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
266834010940	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
266834010941	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
266834010942	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
266834010943	Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945
266834010944	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
266834010945	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834010946	active site
266834010947	motif I; other site
266834010948	motif II; other site
266834010949	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
266834010950	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
266834010951	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
266834010952	nucleotide binding site [chemical binding]; other site
266834010953	Uncharacterized conserved protein [Function unknown]; Region: COG3347
266834010954	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
266834010955	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
266834010956	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
266834010957	intersubunit interface [polypeptide binding]; other site
266834010958	active site
266834010959	Zn2+ binding site [ion binding]; other site
266834010960	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
266834010961	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
266834010962	putative ligand binding site [chemical binding]; other site
266834010963	putative NAD binding site [chemical binding]; other site
266834010964	catalytic site [active]
266834010965	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
266834010966	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
266834010967	putative N- and C-terminal domain interface [polypeptide binding]; other site
266834010968	putative active site [active]
266834010969	MgATP binding site [chemical binding]; other site
266834010970	catalytic site [active]
266834010971	metal binding site [ion binding]; metal-binding site
266834010972	putative xylulose binding site [chemical binding]; other site
266834010973	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
266834010974	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
266834010975	Walker A/P-loop; other site
266834010976	ATP binding site [chemical binding]; other site
266834010977	Q-loop/lid; other site
266834010978	ABC transporter signature motif; other site
266834010979	Walker B; other site
266834010980	D-loop; other site
266834010981	H-loop/switch region; other site
266834010982	TOBE domain; Region: TOBE_2; pfam08402
266834010983	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
266834010984	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834010985	Walker A/P-loop; other site
266834010986	ATP binding site [chemical binding]; other site
266834010987	Q-loop/lid; other site
266834010988	ABC transporter signature motif; other site
266834010989	Walker B; other site
266834010990	D-loop; other site
266834010991	H-loop/switch region; other site
266834010992	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
266834010993	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834010994	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
266834010995	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834010996	dimer interface [polypeptide binding]; other site
266834010997	conserved gate region; other site
266834010998	putative PBP binding loops; other site
266834010999	ABC-ATPase subunit interface; other site
266834011000	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834011001	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834011002	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
266834011003	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
266834011004	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
266834011005	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834011006	DNA binding residues [nucleotide binding]
266834011007	dimerization interface [polypeptide binding]; other site
266834011008	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
266834011009	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
266834011010	Walker A/P-loop; other site
266834011011	ATP binding site [chemical binding]; other site
266834011012	Q-loop/lid; other site
266834011013	ABC transporter signature motif; other site
266834011014	Walker B; other site
266834011015	D-loop; other site
266834011016	H-loop/switch region; other site
266834011017	TOBE domain; Region: TOBE_2; pfam08402
266834011018	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
266834011019	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
266834011020	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834011021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011022	putative PBP binding loops; other site
266834011023	ABC-ATPase subunit interface; other site
266834011024	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834011025	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011026	dimer interface [polypeptide binding]; other site
266834011027	conserved gate region; other site
266834011028	putative PBP binding loops; other site
266834011029	ABC-ATPase subunit interface; other site
266834011030	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834011031	classical (c) SDRs; Region: SDR_c; cd05233
266834011032	NAD(P) binding site [chemical binding]; other site
266834011033	active site
266834011034	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
266834011035	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
266834011036	conserved cys residue [active]
266834011037	Uncharacterized conserved protein [Function unknown]; Region: COG3246
266834011038	bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531
266834011039	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
266834011040	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
266834011041	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
266834011042	active site
266834011043	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
266834011044	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
266834011045	active site
266834011046	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
266834011047	CoA binding domain; Region: CoA_binding_2; pfam13380
266834011048	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
266834011049	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
266834011050	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
266834011051	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
266834011052	substrate binding site [chemical binding]; other site
266834011053	oxyanion hole (OAH) forming residues; other site
266834011054	trimer interface [polypeptide binding]; other site
266834011055	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834011056	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
266834011057	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834011058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011059	dimer interface [polypeptide binding]; other site
266834011060	conserved gate region; other site
266834011061	ABC-ATPase subunit interface; other site
266834011062	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
266834011063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011064	dimer interface [polypeptide binding]; other site
266834011065	conserved gate region; other site
266834011066	ABC-ATPase subunit interface; other site
266834011067	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
266834011068	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834011069	Walker A/P-loop; other site
266834011070	ATP binding site [chemical binding]; other site
266834011071	Q-loop/lid; other site
266834011072	ABC transporter signature motif; other site
266834011073	Walker B; other site
266834011074	D-loop; other site
266834011075	H-loop/switch region; other site
266834011076	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834011077	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834011078	Walker A/P-loop; other site
266834011079	ATP binding site [chemical binding]; other site
266834011080	Q-loop/lid; other site
266834011081	ABC transporter signature motif; other site
266834011082	Walker B; other site
266834011083	D-loop; other site
266834011084	H-loop/switch region; other site
266834011085	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834011086	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834011087	sequence-specific DNA binding site [nucleotide binding]; other site
266834011088	salt bridge; other site
266834011089	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834011090	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
266834011091	Predicted acyl esterases [General function prediction only]; Region: COG2936
266834011092	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
266834011093	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
266834011094	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
266834011095	ACT domain; Region: ACT_3; pfam10000
266834011096	Family description; Region: ACT_7; pfam13840
266834011097	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
266834011098	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834011099	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834011100	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
266834011101	putative substrate binding pocket [chemical binding]; other site
266834011102	dimerization interface [polypeptide binding]; other site
266834011103	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
266834011104	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
266834011105	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
266834011106	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834011107	Walker A/P-loop; other site
266834011108	ATP binding site [chemical binding]; other site
266834011109	Q-loop/lid; other site
266834011110	ABC transporter signature motif; other site
266834011111	Walker B; other site
266834011112	D-loop; other site
266834011113	H-loop/switch region; other site
266834011114	TOBE domain; Region: TOBE_2; pfam08402
266834011115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011116	dimer interface [polypeptide binding]; other site
266834011117	conserved gate region; other site
266834011118	putative PBP binding loops; other site
266834011119	ABC-ATPase subunit interface; other site
266834011120	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834011121	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011122	dimer interface [polypeptide binding]; other site
266834011123	conserved gate region; other site
266834011124	putative PBP binding loops; other site
266834011125	ABC-ATPase subunit interface; other site
266834011126	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
266834011127	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
266834011128	tetrameric interface [polypeptide binding]; other site
266834011129	NAD binding site [chemical binding]; other site
266834011130	catalytic residues [active]
266834011131	substrate binding site [chemical binding]; other site
266834011132	ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049
266834011133	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
266834011134	N-terminal plug; other site
266834011135	ligand-binding site [chemical binding]; other site
266834011136	Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114
266834011137	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
266834011138	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
266834011139	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
266834011140	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
266834011141	putative ligand binding residues [chemical binding]; other site
266834011142	Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598
266834011143	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834011144	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834011145	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
266834011146	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
266834011147	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
266834011148	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834011149	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834011150	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
266834011151	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
266834011152	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834011153	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834011154	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
266834011155	dimerization interface [polypeptide binding]; other site
266834011156	Predicted membrane protein [Function unknown]; Region: COG4425
266834011157	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
266834011158	methionine gamma-lyase; Validated; Region: PRK07049
266834011159	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
266834011160	homodimer interface [polypeptide binding]; other site
266834011161	substrate-cofactor binding pocket; other site
266834011162	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834011163	catalytic residue [active]
266834011164	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
266834011165	dimer interface [polypeptide binding]; other site
266834011166	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834011167	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834011168	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834011169	enoyl-CoA hydratase; Provisional; Region: PRK05980
266834011170	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
266834011171	substrate binding site [chemical binding]; other site
266834011172	oxyanion hole (OAH) forming residues; other site
266834011173	trimer interface [polypeptide binding]; other site
266834011174	Predicted integral membrane protein [Function unknown]; Region: COG5500
266834011175	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
266834011176	Putative glucoamylase; Region: Glycoamylase; pfam10091
266834011177	Uncharacterized conserved protein [Function unknown]; Region: COG1944
266834011178	YcaO-like family; Region: YcaO; pfam02624
266834011179	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
266834011180	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834011181	TPR motif; other site
266834011182	binding surface
266834011183	Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746
266834011184	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834011185	Coenzyme A binding pocket [chemical binding]; other site
266834011186	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
266834011187	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
266834011188	active site
266834011189	substrate binding site [chemical binding]; other site
266834011190	FMN binding site [chemical binding]; other site
266834011191	putative catalytic residues [active]
266834011192	topology modulation protein; Reviewed; Region: PRK08118
266834011193	AAA domain; Region: AAA_17; pfam13207
266834011194	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
266834011195	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834011196	motif II; other site
266834011197	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
266834011198	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834011199	Coenzyme A binding pocket [chemical binding]; other site
266834011200	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424
266834011201	replicative DNA helicase; Provisional; Region: PRK05973
266834011202	Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305
266834011203	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
266834011204	dimer interface [polypeptide binding]; other site
266834011205	substrate binding site [chemical binding]; other site
266834011206	metal binding site [ion binding]; metal-binding site
266834011207	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
266834011208	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
266834011209	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
266834011210	Acid Phosphatase; Region: Acid_PPase; cl17256
266834011211	Uncharacterized conserved protein [Function unknown]; Region: COG2968
266834011212	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
266834011213	conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096
266834011214	Uncharacterized conserved protein [Function unknown]; Region: COG0432
266834011215	Uncharacterized conserved protein [Function unknown]; Region: COG5507
266834011216	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
266834011217	N-acetyl-D-glucosamine binding site [chemical binding]; other site
266834011218	catalytic residue [active]
266834011219	Uncharacterized conserved protein [Function unknown]; Region: COG4274
266834011220	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
266834011221	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
266834011222	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
266834011223	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
266834011224	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
266834011225	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
266834011226	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834011227	DNA binding residues [nucleotide binding]
266834011228	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
266834011229	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
266834011230	NAD(P) binding site [chemical binding]; other site
266834011231	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
266834011232	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
266834011233	substrate-cofactor binding pocket; other site
266834011234	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834011235	catalytic residue [active]
266834011236	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
266834011237	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
266834011238	ATP binding site [chemical binding]; other site
266834011239	putative Mg++ binding site [ion binding]; other site
266834011240	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
266834011241	nucleotide binding region [chemical binding]; other site
266834011242	ATP-binding site [chemical binding]; other site
266834011243	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
266834011244	HRDC domain; Region: HRDC; pfam00570
266834011245	DNA primase; Validated; Region: dnaG; PRK05667
266834011246	CHC2 zinc finger; Region: zf-CHC2; cl17510
266834011247	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
266834011248	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
266834011249	active site
266834011250	metal binding site [ion binding]; metal-binding site
266834011251	interdomain interaction site; other site
266834011252	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
266834011253	Uncharacterized conserved protein [Function unknown]; Region: COG1610
266834011254	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
266834011255	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
266834011256	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
266834011257	catalytic site [active]
266834011258	subunit interface [polypeptide binding]; other site
266834011259	LysR family transcriptional regulator; Provisional; Region: PRK14997
266834011260	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834011261	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834011262	putative effector binding pocket; other site
266834011263	dimerization interface [polypeptide binding]; other site
266834011264	short chain dehydrogenase; Provisional; Region: PRK06500
266834011265	classical (c) SDRs; Region: SDR_c; cd05233
266834011266	NAD(P) binding site [chemical binding]; other site
266834011267	active site
266834011268	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
266834011269	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
266834011270	aspartate aminotransferase; Provisional; Region: PRK05764
266834011271	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834011272	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834011273	homodimer interface [polypeptide binding]; other site
266834011274	catalytic residue [active]
266834011275	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
266834011276	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
266834011277	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
266834011278	EamA-like transporter family; Region: EamA; pfam00892
266834011279	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
266834011280	DNA-binding site [nucleotide binding]; DNA binding site
266834011281	RNA-binding motif; other site
266834011282	BA14K-like protein; Region: BA14K; pfam07886
266834011283	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
266834011284	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
266834011285	Bacterial SH3 domain; Region: SH3_3; pfam08239
266834011286	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
266834011287	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
266834011288	MarR family; Region: MarR_2; pfam12802
266834011289	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834011290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834011291	active site
266834011292	phosphorylation site [posttranslational modification]
266834011293	intermolecular recognition site; other site
266834011294	dimerization interface [polypeptide binding]; other site
266834011295	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834011296	DNA binding site [nucleotide binding]
266834011297	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834011298	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
266834011299	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
266834011300	dimer interface [polypeptide binding]; other site
266834011301	phosphorylation site [posttranslational modification]
266834011302	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834011303	ATP binding site [chemical binding]; other site
266834011304	Mg2+ binding site [ion binding]; other site
266834011305	G-X-G motif; other site
266834011306	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
266834011307	dimer interface [polypeptide binding]; other site
266834011308	putative tRNA-binding site [nucleotide binding]; other site
266834011309	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
266834011310	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
266834011311	Uncharacterized conserved protein [Function unknown]; Region: COG5465
266834011312	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
266834011313	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
266834011314	Uncharacterized conserved protein [Function unknown]; Region: COG1565
266834011315	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
266834011316	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
266834011317	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
266834011318	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
266834011319	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
266834011320	active site
266834011321	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
266834011322	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
266834011323	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
266834011324	active site
266834011325	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
266834011326	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
266834011327	tetramer interface [polypeptide binding]; other site
266834011328	active site
266834011329	Mg2+/Mn2+ binding site [ion binding]; other site
266834011330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564
266834011331	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
266834011332	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
266834011333	NAD(P) binding site [chemical binding]; other site
266834011334	catalytic residues [active]
266834011335	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
266834011336	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
266834011337	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
266834011338	benzoate transporter; Region: benE; TIGR00843
266834011339	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
266834011340	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
266834011341	5S rRNA interface [nucleotide binding]; other site
266834011342	CTC domain interface [polypeptide binding]; other site
266834011343	L16 interface [polypeptide binding]; other site
266834011344	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
266834011345	putative active site [active]
266834011346	catalytic residue [active]
266834011347	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
266834011348	GTP-binding protein YchF; Reviewed; Region: PRK09601
266834011349	YchF GTPase; Region: YchF; cd01900
266834011350	G1 box; other site
266834011351	GTP/Mg2+ binding site [chemical binding]; other site
266834011352	Switch I region; other site
266834011353	G2 box; other site
266834011354	Switch II region; other site
266834011355	G3 box; other site
266834011356	G4 box; other site
266834011357	G5 box; other site
266834011358	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
266834011359	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
266834011360	putative active site [active]
266834011361	putative catalytic site [active]
266834011362	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
266834011363	putative active site [active]
266834011364	putative catalytic site [active]
266834011365	Domain of unknown function (DUF1873); Region: DUF1873; pfam08969
266834011366	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
266834011367	active site
266834011368	Predicted small metal-binding protein [Function unknown]; Region: COG5466
266834011369	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
266834011370	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
266834011371	active site
266834011372	NTP binding site [chemical binding]; other site
266834011373	metal binding triad [ion binding]; metal-binding site
266834011374	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
266834011375	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
266834011376	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
266834011377	putative active site [active]
266834011378	putative CoA binding site [chemical binding]; other site
266834011379	nudix motif; other site
266834011380	metal binding site [ion binding]; metal-binding site
266834011381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
266834011382	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
266834011383	MoxR-like ATPases [General function prediction only]; Region: COG0714
266834011384	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834011385	Walker A motif; other site
266834011386	ATP binding site [chemical binding]; other site
266834011387	Walker B motif; other site
266834011388	arginine finger; other site
266834011389	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
266834011390	Protein of unknown function DUF58; Region: DUF58; pfam01882
266834011391	N-terminal double-transmembrane domain; Region: two_anch; TIGR02226
266834011392	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
266834011393	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
266834011394	CARDB; Region: CARDB; pfam07705
266834011395	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
266834011396	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
266834011397	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834011398	Coenzyme A binding pocket [chemical binding]; other site
266834011399	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
266834011400	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
266834011401	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
266834011402	putative dimer interface [polypeptide binding]; other site
266834011403	N-terminal domain interface [polypeptide binding]; other site
266834011404	putative substrate binding pocket (H-site) [chemical binding]; other site
266834011405	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
266834011406	FIC domain binding interface [polypeptide binding]; other site
266834011407	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
266834011408	Fic/DOC family; Region: Fic; cl00960
266834011409	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
266834011410	nudix motif; other site
266834011411	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
266834011412	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
266834011413	putative active site [active]
266834011414	putative metal binding site [ion binding]; other site
266834011415	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
266834011416	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
266834011417	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
266834011418	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834011419	DNA binding residues [nucleotide binding]
266834011420	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
266834011421	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742
266834011422	putative active site [active]
266834011423	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
266834011424	2-isopropylmalate synthase; Validated; Region: PRK03739
266834011425	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
266834011426	active site
266834011427	catalytic residues [active]
266834011428	metal binding site [ion binding]; metal-binding site
266834011429	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
266834011430	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
266834011431	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
266834011432	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
266834011433	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
266834011434	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
266834011435	oligomer interface [polypeptide binding]; other site
266834011436	active site residues [active]
266834011437	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
266834011438	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
266834011439	Aminoglycoside phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: Aph; COG3231
266834011440	Phosphotransferase enzyme family; Region: APH; pfam01636
266834011441	active site
266834011442	substrate binding site [chemical binding]; other site
266834011443	ATP binding site [chemical binding]; other site
266834011444	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
266834011445	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
266834011446	Cation efflux family; Region: Cation_efflux; cl00316
266834011447	anthranilate synthase; Provisional; Region: PRK13566
266834011448	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
266834011449	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
266834011450	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
266834011451	glutamine binding [chemical binding]; other site
266834011452	catalytic triad [active]
266834011453	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
266834011454	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
266834011455	N-terminal plug; other site
266834011456	ligand-binding site [chemical binding]; other site
266834011457	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
266834011458	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
266834011459	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
266834011460	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
266834011461	Potassium binding sites [ion binding]; other site
266834011462	Cesium cation binding sites [ion binding]; other site
266834011463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345
266834011464	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
266834011465	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
266834011466	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
266834011467	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
266834011468	putative active site [active]
266834011469	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
266834011470	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
266834011471	thymidine kinase; Provisional; Region: PRK04296
266834011472	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
266834011473	ATP binding site [chemical binding]; other site
266834011474	Walker A motif; other site
266834011475	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
266834011476	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
266834011477	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011478	dimer interface [polypeptide binding]; other site
266834011479	conserved gate region; other site
266834011480	putative PBP binding loops; other site
266834011481	ABC-ATPase subunit interface; other site
266834011482	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
266834011483	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834011484	Walker A/P-loop; other site
266834011485	ATP binding site [chemical binding]; other site
266834011486	Q-loop/lid; other site
266834011487	ABC transporter signature motif; other site
266834011488	Walker B; other site
266834011489	D-loop; other site
266834011490	H-loop/switch region; other site
266834011491	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
266834011492	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
266834011493	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
266834011494	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
266834011495	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834011496	dimerization interface [polypeptide binding]; other site
266834011497	putative DNA binding site [nucleotide binding]; other site
266834011498	putative Zn2+ binding site [ion binding]; other site
266834011499	AAA domain; Region: AAA_33; pfam13671
266834011500	AAA domain; Region: AAA_17; pfam13207
266834011501	omega amino acid--pyruvate transaminase; Provisional; Region: PRK13360
266834011502	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834011503	inhibitor-cofactor binding pocket; inhibition site
266834011504	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834011505	catalytic residue [active]
266834011506	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
266834011507	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
266834011508	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
266834011509	active site
266834011510	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
266834011511	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
266834011512	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
266834011513	active site
266834011514	catalytic site [active]
266834011515	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
266834011516	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
266834011517	substrate binding site [chemical binding]; other site
266834011518	ATP binding site [chemical binding]; other site
266834011519	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834011520	MULE transposase domain; Region: MULE; pfam10551
266834011521	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
266834011522	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834011523	Walker A/P-loop; other site
266834011524	ATP binding site [chemical binding]; other site
266834011525	Q-loop/lid; other site
266834011526	ABC transporter signature motif; other site
266834011527	Walker B; other site
266834011528	D-loop; other site
266834011529	H-loop/switch region; other site
266834011530	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
266834011531	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834011532	Walker A/P-loop; other site
266834011533	ATP binding site [chemical binding]; other site
266834011534	Q-loop/lid; other site
266834011535	ABC transporter signature motif; other site
266834011536	Walker B; other site
266834011537	D-loop; other site
266834011538	H-loop/switch region; other site
266834011539	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834011540	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
266834011541	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011542	ABC-ATPase subunit interface; other site
266834011543	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834011544	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011545	dimer interface [polypeptide binding]; other site
266834011546	conserved gate region; other site
266834011547	putative PBP binding loops; other site
266834011548	ABC-ATPase subunit interface; other site
266834011549	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834011550	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
266834011551	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
266834011552	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
266834011553	active site
266834011554	dimer interface [polypeptide binding]; other site
266834011555	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
266834011556	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834011557	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834011558	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
266834011559	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
266834011560	oligomeric interface; other site
266834011561	putative active site [active]
266834011562	homodimer interface [polypeptide binding]; other site
266834011563	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
266834011564	apolar tunnel; other site
266834011565	heme binding site [chemical binding]; other site
266834011566	dimerization interface [polypeptide binding]; other site
266834011567	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
266834011568	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
266834011569	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
266834011570	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
266834011571	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
266834011572	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
266834011573	Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256
266834011574	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
266834011575	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
266834011576	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
266834011577	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
266834011578	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
266834011579	putative hemin binding site; other site
266834011580	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
266834011581	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
266834011582	ABC-ATPase subunit  interface; other site
266834011583	dimer interface [polypeptide binding]; other site
266834011584	putative PBP binding regions; other site
266834011585	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
266834011586	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
266834011587	Walker A/P-loop; other site
266834011588	ATP binding site [chemical binding]; other site
266834011589	Q-loop/lid; other site
266834011590	ABC transporter signature motif; other site
266834011591	Walker B; other site
266834011592	D-loop; other site
266834011593	H-loop/switch region; other site
266834011594	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
266834011595	GAF domain; Region: GAF; pfam01590
266834011596	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834011597	PAS fold; Region: PAS_3; pfam08447
266834011598	putative active site [active]
266834011599	heme pocket [chemical binding]; other site
266834011600	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
266834011601	HWE histidine kinase; Region: HWE_HK; pfam07536
266834011602	RNA polymerase sigma factor; Provisional; Region: PRK12516
266834011603	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
266834011604	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834011605	DNA binding residues [nucleotide binding]
266834011606	two-component response regulator; Provisional; Region: PRK09191
266834011607	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834011608	active site
266834011609	phosphorylation site [posttranslational modification]
266834011610	intermolecular recognition site; other site
266834011611	dimerization interface [polypeptide binding]; other site
266834011612	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
266834011613	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
266834011614	N- and C-terminal domain interface [polypeptide binding]; other site
266834011615	active site
266834011616	MgATP binding site [chemical binding]; other site
266834011617	catalytic site [active]
266834011618	metal binding site [ion binding]; metal-binding site
266834011619	carbohydrate binding site [chemical binding]; other site
266834011620	putative homodimer interface [polypeptide binding]; other site
266834011621	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
266834011622	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834011623	motif II; other site
266834011624	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
266834011625	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
266834011626	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
266834011627	sorbitol dehydrogenase; Provisional; Region: PRK07067
266834011628	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834011629	NAD(P) binding site [chemical binding]; other site
266834011630	active site
266834011631	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
266834011632	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834011633	Walker A/P-loop; other site
266834011634	ATP binding site [chemical binding]; other site
266834011635	Q-loop/lid; other site
266834011636	ABC transporter signature motif; other site
266834011637	Walker B; other site
266834011638	D-loop; other site
266834011639	H-loop/switch region; other site
266834011640	TOBE domain; Region: TOBE_2; pfam08402
266834011641	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834011642	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011643	dimer interface [polypeptide binding]; other site
266834011644	conserved gate region; other site
266834011645	putative PBP binding loops; other site
266834011646	ABC-ATPase subunit interface; other site
266834011647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011648	dimer interface [polypeptide binding]; other site
266834011649	conserved gate region; other site
266834011650	putative PBP binding loops; other site
266834011651	ABC-ATPase subunit interface; other site
266834011652	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834011653	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834011654	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
266834011655	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
266834011656	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
266834011657	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
266834011658	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
266834011659	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
266834011660	homodimer interface [polypeptide binding]; other site
266834011661	active site
266834011662	FMN binding site [chemical binding]; other site
266834011663	substrate binding site [chemical binding]; other site
266834011664	4Fe-4S binding domain; Region: Fer4_6; pfam12837
266834011665	4Fe-4S binding domain; Region: Fer4; pfam00037
266834011666	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
266834011667	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
266834011668	putative NAD(P) binding site [chemical binding]; other site
266834011669	LysR family transcriptional regulator; Provisional; Region: PRK14997
266834011670	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834011671	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
266834011672	putative effector binding pocket; other site
266834011673	putative dimerization interface [polypeptide binding]; other site
266834011674	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
266834011675	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834011676	catalytic loop [active]
266834011677	iron binding site [ion binding]; other site
266834011678	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834011679	cyclase homology domain; Region: CHD; cd07302
266834011680	nucleotidyl binding site; other site
266834011681	metal binding site [ion binding]; metal-binding site
266834011682	dimer interface [polypeptide binding]; other site
266834011683	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
266834011684	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834011685	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
266834011686	allantoate amidohydrolase; Reviewed; Region: PRK12893
266834011687	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
266834011688	active site
266834011689	metal binding site [ion binding]; metal-binding site
266834011690	dimer interface [polypeptide binding]; other site
266834011691	phenylhydantoinase; Validated; Region: PRK08323
266834011692	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
266834011693	tetramer interface [polypeptide binding]; other site
266834011694	active site
266834011695	Predicted mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: COG4101
266834011696	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
266834011697	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
266834011698	Walker A/P-loop; other site
266834011699	ATP binding site [chemical binding]; other site
266834011700	Q-loop/lid; other site
266834011701	ABC transporter signature motif; other site
266834011702	Walker B; other site
266834011703	D-loop; other site
266834011704	H-loop/switch region; other site
266834011705	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
266834011706	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834011707	Coenzyme A binding pocket [chemical binding]; other site
266834011708	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
266834011709	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011710	dimer interface [polypeptide binding]; other site
266834011711	conserved gate region; other site
266834011712	putative PBP binding loops; other site
266834011713	ABC-ATPase subunit interface; other site
266834011714	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
266834011715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011716	dimer interface [polypeptide binding]; other site
266834011717	conserved gate region; other site
266834011718	putative PBP binding loops; other site
266834011719	ABC-ATPase subunit interface; other site
266834011720	NMT1/THI5 like; Region: NMT1; pfam09084
266834011721	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
266834011722	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834011723	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834011724	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
266834011725	Protein export membrane protein; Region: SecD_SecF; cl14618
266834011726	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
266834011727	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
266834011728	UreF; Region: UreF; pfam01730
266834011729	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
266834011730	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
266834011731	dimer interface [polypeptide binding]; other site
266834011732	catalytic residues [active]
266834011733	Uncharacterized conserved protein [Function unknown]; Region: COG1359
266834011734	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
266834011735	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
266834011736	catalytic triad [active]
266834011737	dimer interface [polypeptide binding]; other site
266834011738	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
266834011739	Predicted transcriptional regulator [Transcription]; Region: COG2944
266834011740	urease subunit alpha; Reviewed; Region: ureC; PRK13207
266834011741	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
266834011742	subunit interactions [polypeptide binding]; other site
266834011743	active site
266834011744	flap region; other site
266834011745	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
266834011746	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
266834011747	alpha-beta subunit interface [polypeptide binding]; other site
266834011748	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
266834011749	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
266834011750	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
266834011751	alpha-gamma subunit interface [polypeptide binding]; other site
266834011752	beta-gamma subunit interface [polypeptide binding]; other site
266834011753	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
266834011754	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
266834011755	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
266834011756	dimerization interface [polypeptide binding]; other site
266834011757	ligand binding site [chemical binding]; other site
266834011758	NADP binding site [chemical binding]; other site
266834011759	catalytic site [active]
266834011760	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
266834011761	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
266834011762	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
266834011763	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
266834011764	MarR family; Region: MarR; pfam01047
266834011765	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
266834011766	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
266834011767	dimerization interface [polypeptide binding]; other site
266834011768	ligand binding site [chemical binding]; other site
266834011769	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
266834011770	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
266834011771	Walker A/P-loop; other site
266834011772	ATP binding site [chemical binding]; other site
266834011773	Q-loop/lid; other site
266834011774	ABC transporter signature motif; other site
266834011775	Walker B; other site
266834011776	D-loop; other site
266834011777	H-loop/switch region; other site
266834011778	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
266834011779	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
266834011780	Walker A/P-loop; other site
266834011781	ATP binding site [chemical binding]; other site
266834011782	Q-loop/lid; other site
266834011783	ABC transporter signature motif; other site
266834011784	Walker B; other site
266834011785	D-loop; other site
266834011786	H-loop/switch region; other site
266834011787	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
266834011788	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
266834011789	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
266834011790	TM-ABC transporter signature motif; other site
266834011791	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834011792	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
266834011793	TM-ABC transporter signature motif; other site
266834011794	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
266834011795	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
266834011796	active site
266834011797	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
266834011798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
266834011799	active site
266834011800	phosphorylation site [posttranslational modification]
266834011801	intermolecular recognition site; other site
266834011802	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
266834011803	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
266834011804	ligand binding site [chemical binding]; other site
266834011805	flexible hinge region; other site
266834011806	putative switch regulator; other site
266834011807	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
266834011808	non-specific DNA interactions [nucleotide binding]; other site
266834011809	DNA binding site [nucleotide binding]
266834011810	sequence specific DNA binding site [nucleotide binding]; other site
266834011811	putative cAMP binding site [chemical binding]; other site
266834011812	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
266834011813	classical (c) SDRs; Region: SDR_c; cd05233
266834011814	NAD(P) binding site [chemical binding]; other site
266834011815	active site
266834011816	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
266834011817	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834011818	Zn binding site [ion binding]; other site
266834011819	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
266834011820	Zn binding site [ion binding]; other site
266834011821	Predicted esterase [General function prediction only]; Region: COG0400
266834011822	putative hydrolase; Provisional; Region: PRK11460
266834011823	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
266834011824	HTH-like domain; Region: HTH_21; pfam13276
266834011825	Integrase core domain; Region: rve; pfam00665
266834011826	Integrase core domain; Region: rve_3; pfam13683
266834011827	Transposase; Region: HTH_Tnp_1; cl17663
266834011828	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834011829	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
266834011830	Predicted flavoprotein [General function prediction only]; Region: COG0431
266834011831	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
266834011832	Zn binding site [ion binding]; other site
266834011833	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
266834011834	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834011835	Zn binding site [ion binding]; other site
266834011836	Predicted amidohydrolase [General function prediction only]; Region: COG0388
266834011837	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
266834011838	putative active site [active]
266834011839	catalytic triad [active]
266834011840	putative dimer interface [polypeptide binding]; other site
266834011841	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834011842	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011843	dimer interface [polypeptide binding]; other site
266834011844	conserved gate region; other site
266834011845	putative PBP binding loops; other site
266834011846	ABC-ATPase subunit interface; other site
266834011847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011848	putative PBP binding loops; other site
266834011849	ABC-ATPase subunit interface; other site
266834011850	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
266834011851	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834011852	Walker A/P-loop; other site
266834011853	ATP binding site [chemical binding]; other site
266834011854	Q-loop/lid; other site
266834011855	ABC transporter signature motif; other site
266834011856	Walker B; other site
266834011857	D-loop; other site
266834011858	H-loop/switch region; other site
266834011859	TOBE domain; Region: TOBE_2; pfam08402
266834011860	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
266834011861	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
266834011862	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
266834011863	agmatinase; Region: agmatinase; TIGR01230
266834011864	oligomer interface [polypeptide binding]; other site
266834011865	putative active site [active]
266834011866	Mn binding site [ion binding]; other site
266834011867	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
266834011868	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834011869	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
266834011870	dimerization interface [polypeptide binding]; other site
266834011871	substrate binding pocket [chemical binding]; other site
266834011872	hypothetical protein; Provisional; Region: PRK07550
266834011873	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834011874	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834011875	homodimer interface [polypeptide binding]; other site
266834011876	catalytic residue [active]
266834011877	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
266834011878	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
266834011879	NAD binding site [chemical binding]; other site
266834011880	catalytic residues [active]
266834011881	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
266834011882	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834011883	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
266834011884	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
266834011885	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834011886	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834011887	DNA-binding site [nucleotide binding]; DNA binding site
266834011888	FCD domain; Region: FCD; pfam07729
266834011889	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834011890	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834011891	DNA-binding site [nucleotide binding]; DNA binding site
266834011892	FCD domain; Region: FCD; pfam07729
266834011893	hypothetical protein; Provisional; Region: PRK05968
266834011894	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
266834011895	homodimer interface [polypeptide binding]; other site
266834011896	substrate-cofactor binding pocket; other site
266834011897	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834011898	catalytic residue [active]
266834011899	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834011900	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834011901	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011902	dimer interface [polypeptide binding]; other site
266834011903	conserved gate region; other site
266834011904	putative PBP binding loops; other site
266834011905	ABC-ATPase subunit interface; other site
266834011906	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834011907	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834011908	dimer interface [polypeptide binding]; other site
266834011909	conserved gate region; other site
266834011910	putative PBP binding loops; other site
266834011911	ABC-ATPase subunit interface; other site
266834011912	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834011913	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834011914	Walker A/P-loop; other site
266834011915	ATP binding site [chemical binding]; other site
266834011916	Q-loop/lid; other site
266834011917	ABC transporter signature motif; other site
266834011918	Walker B; other site
266834011919	D-loop; other site
266834011920	H-loop/switch region; other site
266834011921	TOBE domain; Region: TOBE_2; pfam08402
266834011922	Cytochrome c2 [Energy production and conversion]; Region: COG3474
266834011923	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
266834011924	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
266834011925	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
266834011926	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
266834011927	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
266834011928	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865
266834011929	Subunit I/III interface [polypeptide binding]; other site
266834011930	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864
266834011931	Subunit I/III interface [polypeptide binding]; other site
266834011932	Predicted small integral membrane protein [Function unknown]; Region: COG5605
266834011933	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834011934	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834011935	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
266834011936	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
266834011937	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
266834011938	active site
266834011939	metal binding site [ion binding]; metal-binding site
266834011940	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834011941	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
266834011942	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834011943	short chain dehydrogenase; Provisional; Region: PRK07060
266834011944	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834011945	NAD(P) binding site [chemical binding]; other site
266834011946	active site
266834011947	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
266834011948	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
266834011949	inhibitor binding site; inhibition site
266834011950	catalytic Zn binding site [ion binding]; other site
266834011951	structural Zn binding site [ion binding]; other site
266834011952	NADP binding site [chemical binding]; other site
266834011953	tetramer interface [polypeptide binding]; other site
266834011954	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
266834011955	[2Fe-2S] cluster binding site [ion binding]; other site
266834011956	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
266834011957	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834011958	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
266834011959	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
266834011960	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834011961	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834011962	TM-ABC transporter signature motif; other site
266834011963	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
266834011964	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834011965	Walker A/P-loop; other site
266834011966	ATP binding site [chemical binding]; other site
266834011967	Q-loop/lid; other site
266834011968	ABC transporter signature motif; other site
266834011969	Walker B; other site
266834011970	D-loop; other site
266834011971	H-loop/switch region; other site
266834011972	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
266834011973	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
266834011974	putative ligand binding site [chemical binding]; other site
266834011975	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834011976	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834011977	DNA binding site [nucleotide binding]
266834011978	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
266834011979	putative ligand binding site [chemical binding]; other site
266834011980	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
266834011981	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
266834011982	putative metal binding site [ion binding]; other site
266834011983	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834011984	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
266834011985	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
266834011986	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
266834011987	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
266834011988	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834011989	Walker A/P-loop; other site
266834011990	ATP binding site [chemical binding]; other site
266834011991	Q-loop/lid; other site
266834011992	ABC transporter signature motif; other site
266834011993	Walker B; other site
266834011994	D-loop; other site
266834011995	H-loop/switch region; other site
266834011996	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834011997	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834011998	Walker A/P-loop; other site
266834011999	ATP binding site [chemical binding]; other site
266834012000	Q-loop/lid; other site
266834012001	ABC transporter signature motif; other site
266834012002	Walker B; other site
266834012003	D-loop; other site
266834012004	H-loop/switch region; other site
266834012005	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834012006	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
266834012007	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834012008	dimer interface [polypeptide binding]; other site
266834012009	conserved gate region; other site
266834012010	putative PBP binding loops; other site
266834012011	ABC-ATPase subunit interface; other site
266834012012	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834012013	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
266834012014	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834012015	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834012016	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
266834012017	putative dimerization interface [polypeptide binding]; other site
266834012018	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834012019	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834012020	TM-ABC transporter signature motif; other site
266834012021	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834012022	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834012023	Walker A/P-loop; other site
266834012024	ATP binding site [chemical binding]; other site
266834012025	Q-loop/lid; other site
266834012026	ABC transporter signature motif; other site
266834012027	Walker B; other site
266834012028	D-loop; other site
266834012029	H-loop/switch region; other site
266834012030	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834012031	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834012032	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
266834012033	ligand binding site [chemical binding]; other site
266834012034	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834012035	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834012036	NAD(P) binding site [chemical binding]; other site
266834012037	active site
266834012038	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
266834012039	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834012040	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834012041	DNA-binding site [nucleotide binding]; DNA binding site
266834012042	FCD domain; Region: FCD; pfam07729
266834012043	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834012044	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834012045	NAD(P) binding site [chemical binding]; other site
266834012046	active site
266834012047	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
266834012048	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
266834012049	dimer interface [polypeptide binding]; other site
266834012050	active site
266834012051	metal binding site [ion binding]; metal-binding site
266834012052	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
266834012053	classical (c) SDRs; Region: SDR_c; cd05233
266834012054	NAD(P) binding site [chemical binding]; other site
266834012055	active site
266834012056	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
266834012057	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834012058	active site
266834012059	short chain dehydrogenase; Provisional; Region: PRK06841
266834012060	classical (c) SDRs; Region: SDR_c; cd05233
266834012061	NAD(P) binding site [chemical binding]; other site
266834012062	active site
266834012063	glucose-6-phosphate isomerase; Provisional; Region: PRK04190
266834012064	Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560
266834012065	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
266834012066	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
266834012067	active site
266834012068	intersubunit interface [polypeptide binding]; other site
266834012069	catalytic residue [active]
266834012070	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
266834012071	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
266834012072	NAD(P) binding pocket [chemical binding]; other site
266834012073	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
266834012074	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
266834012075	putative ligand binding site [chemical binding]; other site
266834012076	putative NAD binding site [chemical binding]; other site
266834012077	catalytic site [active]
266834012078	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
266834012079	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
266834012080	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
266834012081	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
266834012082	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
266834012083	putative active site [active]
266834012084	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
266834012085	intersubunit interface [polypeptide binding]; other site
266834012086	active site
266834012087	catalytic residue [active]
266834012088	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
266834012089	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805
266834012090	N- and C-terminal domain interface [polypeptide binding]; other site
266834012091	active site
266834012092	MgATP binding site [chemical binding]; other site
266834012093	catalytic site [active]
266834012094	metal binding site [ion binding]; metal-binding site
266834012095	xylulose binding site [chemical binding]; other site
266834012096	putative homodimer interface [polypeptide binding]; other site
266834012097	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
266834012098	D-xylulose kinases, subgroup 3; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_3; cd07811
266834012099	putative N- and C-terminal domain interface [polypeptide binding]; other site
266834012100	putative active site [active]
266834012101	putative MgATP binding site [chemical binding]; other site
266834012102	catalytic site [active]
266834012103	metal binding site [ion binding]; metal-binding site
266834012104	putative xylulose binding site [chemical binding]; other site
266834012105	putative homodimer interface [polypeptide binding]; other site
266834012106	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
266834012107	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834012108	NAD(P) binding site [chemical binding]; other site
266834012109	active site
266834012110	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834012111	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834012112	TM-ABC transporter signature motif; other site
266834012113	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834012114	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834012115	Walker A/P-loop; other site
266834012116	ATP binding site [chemical binding]; other site
266834012117	Q-loop/lid; other site
266834012118	ABC transporter signature motif; other site
266834012119	Walker B; other site
266834012120	D-loop; other site
266834012121	H-loop/switch region; other site
266834012122	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834012123	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834012124	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318
266834012125	putative ligand binding site [chemical binding]; other site
266834012126	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834012127	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834012128	NAD(P) binding site [chemical binding]; other site
266834012129	active site
266834012130	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
266834012131	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834012132	DNA-binding site [nucleotide binding]; DNA binding site
266834012133	UTRA domain; Region: UTRA; pfam07702
266834012134	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
266834012135	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
266834012136	N- and C-terminal domain interface [polypeptide binding]; other site
266834012137	active site
266834012138	MgATP binding site [chemical binding]; other site
266834012139	catalytic site [active]
266834012140	metal binding site [ion binding]; metal-binding site
266834012141	xylulose binding site [chemical binding]; other site
266834012142	homodimer interface [polypeptide binding]; other site
266834012143	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
266834012144	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
266834012145	TPP-binding site [chemical binding]; other site
266834012146	dimer interface [polypeptide binding]; other site
266834012147	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
266834012148	PYR/PP interface [polypeptide binding]; other site
266834012149	dimer interface [polypeptide binding]; other site
266834012150	TPP binding site [chemical binding]; other site
266834012151	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
266834012152	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834012153	putative transporter; Provisional; Region: PRK10504
266834012154	putative substrate translocation pore; other site
266834012155	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
266834012156	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834012157	substrate binding pocket [chemical binding]; other site
266834012158	membrane-bound complex binding site; other site
266834012159	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
266834012160	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834012161	dimer interface [polypeptide binding]; other site
266834012162	conserved gate region; other site
266834012163	putative PBP binding loops; other site
266834012164	ABC-ATPase subunit interface; other site
266834012165	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
266834012166	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
266834012167	Walker A/P-loop; other site
266834012168	ATP binding site [chemical binding]; other site
266834012169	Q-loop/lid; other site
266834012170	ABC transporter signature motif; other site
266834012171	Walker B; other site
266834012172	D-loop; other site
266834012173	H-loop/switch region; other site
266834012174	Ferredoxin [Energy production and conversion]; Region: COG1146
266834012175	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
266834012176	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
266834012177	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
266834012178	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
266834012179	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
266834012180	putative catalytic residue [active]
266834012181	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
266834012182	apolar tunnel; other site
266834012183	heme binding site [chemical binding]; other site
266834012184	dimerization interface [polypeptide binding]; other site
266834012185	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
266834012186	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
266834012187	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
266834012188	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
266834012189	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
266834012190	putative active site [active]
266834012191	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
266834012192	Isochorismatase family; Region: Isochorismatase; pfam00857
266834012193	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
266834012194	catalytic triad [active]
266834012195	conserved cis-peptide bond; other site
266834012196	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
266834012197	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
266834012198	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
266834012199	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
266834012200	Walker A/P-loop; other site
266834012201	ATP binding site [chemical binding]; other site
266834012202	Q-loop/lid; other site
266834012203	ABC transporter signature motif; other site
266834012204	Walker B; other site
266834012205	D-loop; other site
266834012206	H-loop/switch region; other site
266834012207	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
266834012208	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
266834012209	Walker A/P-loop; other site
266834012210	ATP binding site [chemical binding]; other site
266834012211	Q-loop/lid; other site
266834012212	ABC transporter signature motif; other site
266834012213	Walker B; other site
266834012214	D-loop; other site
266834012215	H-loop/switch region; other site
266834012216	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
266834012217	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834012218	TM-ABC transporter signature motif; other site
266834012219	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
266834012220	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
266834012221	TM-ABC transporter signature motif; other site
266834012222	Isochorismatase family; Region: Isochorismatase; pfam00857
266834012223	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
266834012224	catalytic triad [active]
266834012225	conserved cis-peptide bond; other site
266834012226	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
266834012227	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834012228	inhibitor-cofactor binding pocket; inhibition site
266834012229	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834012230	catalytic residue [active]
266834012231	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
266834012232	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
266834012233	active site
266834012234	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
266834012235	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834012236	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151
266834012237	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
266834012238	active site
266834012239	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834012240	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
266834012241	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834012242	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834012243	dimer interface [polypeptide binding]; other site
266834012244	conserved gate region; other site
266834012245	putative PBP binding loops; other site
266834012246	ABC-ATPase subunit interface; other site
266834012247	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
266834012248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834012249	dimer interface [polypeptide binding]; other site
266834012250	conserved gate region; other site
266834012251	putative PBP binding loops; other site
266834012252	ABC-ATPase subunit interface; other site
266834012253	cytosine deaminase; Provisional; Region: PRK05985
266834012254	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
266834012255	active site
266834012256	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151
266834012257	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
266834012258	active site
266834012259	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
266834012260	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834012261	Walker A/P-loop; other site
266834012262	ATP binding site [chemical binding]; other site
266834012263	Q-loop/lid; other site
266834012264	ABC transporter signature motif; other site
266834012265	Walker B; other site
266834012266	D-loop; other site
266834012267	H-loop/switch region; other site
266834012268	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834012269	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
266834012270	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834012271	Walker A/P-loop; other site
266834012272	ATP binding site [chemical binding]; other site
266834012273	Q-loop/lid; other site
266834012274	ABC transporter signature motif; other site
266834012275	Walker B; other site
266834012276	D-loop; other site
266834012277	H-loop/switch region; other site
266834012278	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
266834012279	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
266834012280	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834012281	DNA-binding site [nucleotide binding]; DNA binding site
266834012282	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
266834012283	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
266834012284	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
266834012285	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834012286	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
266834012287	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
266834012288	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
266834012289	[2Fe-2S] cluster binding site [ion binding]; other site
266834012290	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834012291	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834012292	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
266834012293	putative effector binding pocket; other site
266834012294	putative dimerization interface [polypeptide binding]; other site
266834012295	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
266834012296	Transposase domain (DUF772); Region: DUF772; pfam05598
266834012297	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
266834012298	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
266834012299	rrn OR SMc02939; predicted by Homology
266834012300	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
266834012301	Peptidase family M23; Region: Peptidase_M23; pfam01551
266834012302	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
266834012303	Clp amino terminal domain; Region: Clp_N; pfam02861
266834012304	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834012305	Walker A motif; other site
266834012306	ATP binding site [chemical binding]; other site
266834012307	Walker B motif; other site
266834012308	arginine finger; other site
266834012309	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834012310	Walker A motif; other site
266834012311	ATP binding site [chemical binding]; other site
266834012312	Walker B motif; other site
266834012313	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
266834012314	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
266834012315	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
266834012316	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834012317	S-adenosylmethionine binding site [chemical binding]; other site
266834012318	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
266834012319	peptide chain release factor 1; Validated; Region: prfA; PRK00591
266834012320	This domain is found in peptide chain release factors; Region: PCRF; smart00937
266834012321	RF-1 domain; Region: RF-1; pfam00472
266834012322	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
266834012323	GAF domain; Region: GAF; pfam01590
266834012324	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
266834012325	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
266834012326	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
266834012327	aspartate kinase; Reviewed; Region: PRK06635
266834012328	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
266834012329	putative nucleotide binding site [chemical binding]; other site
266834012330	putative catalytic residues [active]
266834012331	putative Mg ion binding site [ion binding]; other site
266834012332	putative aspartate binding site [chemical binding]; other site
266834012333	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
266834012334	putative allosteric regulatory site; other site
266834012335	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
266834012336	RibD C-terminal domain; Region: RibD_C; cl17279
266834012337	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
266834012338	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
266834012339	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834012340	S-adenosylmethionine binding site [chemical binding]; other site
266834012341	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319
266834012342	Predicted amidohydrolase [General function prediction only]; Region: COG0388
266834012343	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
266834012344	putative active site [active]
266834012345	catalytic triad [active]
266834012346	dimer interface [polypeptide binding]; other site
266834012347	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
266834012348	GSH binding site [chemical binding]; other site
266834012349	catalytic residues [active]
266834012350	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
266834012351	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
266834012352	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
266834012353	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
266834012354	active site
266834012355	8-oxo-dGMP binding site [chemical binding]; other site
266834012356	nudix motif; other site
266834012357	metal binding site [ion binding]; metal-binding site
266834012358	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834012359	Coenzyme A binding pocket [chemical binding]; other site
266834012360	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
266834012361	heterotetramer interface [polypeptide binding]; other site
266834012362	active site pocket [active]
266834012363	cleavage site
266834012364	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
266834012365	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
266834012366	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
266834012367	SEC-C motif; Region: SEC-C; pfam02810
266834012368	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
266834012369	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834012370	putative substrate translocation pore; other site
266834012371	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
266834012372	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
266834012373	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
266834012374	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
266834012375	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971
266834012376	active site
266834012377	acyl-activating enzyme (AAE) consensus motif; other site
266834012378	putative CoA binding site [chemical binding]; other site
266834012379	AMP binding site [chemical binding]; other site
266834012380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
266834012381	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
266834012382	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834012383	Coenzyme A binding pocket [chemical binding]; other site
266834012384	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
266834012385	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
266834012386	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
266834012387	active site
266834012388	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
266834012389	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
266834012390	minor groove reading motif; other site
266834012391	helix-hairpin-helix signature motif; other site
266834012392	substrate binding pocket [chemical binding]; other site
266834012393	active site
266834012394	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
266834012395	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
266834012396	active site
266834012397	HIGH motif; other site
266834012398	nucleotide binding site [chemical binding]; other site
266834012399	active site
266834012400	KMSKS motif; other site
266834012401	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
266834012402	short chain dehydrogenase; Provisional; Region: PRK05993
266834012403	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
266834012404	NADP binding site [chemical binding]; other site
266834012405	active site
266834012406	steroid binding site; other site
266834012407	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
266834012408	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
266834012409	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
266834012410	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
266834012411	Ligand binding site [chemical binding]; other site
266834012412	Electron transfer flavoprotein domain; Region: ETF; pfam01012
266834012413	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
266834012414	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
266834012415	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
266834012416	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
266834012417	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
266834012418	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
266834012419	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
266834012420	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
266834012421	catalytic residues [active]
266834012422	argininosuccinate lyase; Provisional; Region: PRK00855
266834012423	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
266834012424	active sites [active]
266834012425	tetramer interface [polypeptide binding]; other site
266834012426	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
266834012427	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
266834012428	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
266834012429	active site
266834012430	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
266834012431	substrate binding site [chemical binding]; other site
266834012432	catalytic residues [active]
266834012433	dimer interface [polypeptide binding]; other site
266834012434	TIGR02302 family protein; Region: aProt_lowcomp
266834012435	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
266834012436	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
266834012437	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
266834012438	Response regulator receiver domain; Region: Response_reg; pfam00072
266834012439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834012440	active site
266834012441	phosphorylation site [posttranslational modification]
266834012442	intermolecular recognition site; other site
266834012443	dimerization interface [polypeptide binding]; other site
266834012444	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
266834012445	active site
266834012446	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
266834012447	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
266834012448	Walker A/P-loop; other site
266834012449	ATP binding site [chemical binding]; other site
266834012450	Q-loop/lid; other site
266834012451	ABC transporter signature motif; other site
266834012452	Walker B; other site
266834012453	D-loop; other site
266834012454	H-loop/switch region; other site
266834012455	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
266834012456	Uncharacterized conserved protein [Function unknown]; Region: COG1434
266834012457	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
266834012458	putative active site [active]
266834012459	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
266834012460	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
266834012461	putative acyl-acceptor binding pocket; other site
266834012462	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
266834012463	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
266834012464	putative active site pocket [active]
266834012465	dimerization interface [polypeptide binding]; other site
266834012466	putative catalytic residue [active]
266834012467	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093
266834012468	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
266834012469	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
266834012470	prephenate dehydrogenase; Validated; Region: PRK08507
266834012471	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
266834012472	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834012473	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834012474	homodimer interface [polypeptide binding]; other site
266834012475	catalytic residue [active]
266834012476	Methyltransferase domain; Region: Methyltransf_23; pfam13489
266834012477	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834012478	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
266834012479	Uncharacterized conserved protein [Function unknown]; Region: COG3542
266834012480	aromatic amino acid exporter; Provisional; Region: PRK11689
266834012481	EamA-like transporter family; Region: EamA; pfam00892
266834012482	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
266834012483	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
266834012484	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
266834012485	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
266834012486	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
266834012487	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
266834012488	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
266834012489	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
266834012490	metal ion-dependent adhesion site (MIDAS); other site
266834012491	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
266834012492	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
266834012493	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
266834012494	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
266834012495	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
266834012496	HSP70 interaction site [polypeptide binding]; other site
266834012497	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
266834012498	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
266834012499	Domain of unknown function DUF21; Region: DUF21; pfam01595
266834012500	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
266834012501	Transporter associated domain; Region: CorC_HlyC; smart01091
266834012502	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
266834012503	active site
266834012504	dimer interface [polypeptide binding]; other site
266834012505	metal binding site [ion binding]; metal-binding site
266834012506	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
266834012507	AAA domain; Region: AAA_18; pfam13238
266834012508	ADP binding site [chemical binding]; other site
266834012509	magnesium binding site [ion binding]; other site
266834012510	putative shikimate binding site; other site
266834012511	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
266834012512	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
266834012513	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
266834012514	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
266834012515	active site
266834012516	DNA binding site [nucleotide binding]
266834012517	Int/Topo IB signature motif; other site
266834012518	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
266834012519	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
266834012520	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
266834012521	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
266834012522	CPxP  motif; other site
266834012523	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
266834012524	oligomeric interface; other site
266834012525	putative active site [active]
266834012526	homodimer interface [polypeptide binding]; other site
266834012527	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
266834012528	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
266834012529	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
266834012530	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
266834012531	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
266834012532	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
266834012533	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
266834012534	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
266834012535	metal binding site [ion binding]; metal-binding site
266834012536	putative dimer interface [polypeptide binding]; other site
266834012537	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834012538	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834012539	putative DNA binding site [nucleotide binding]; other site
266834012540	putative Zn2+ binding site [ion binding]; other site
266834012541	AsnC family; Region: AsnC_trans_reg; pfam01037
266834012542	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
266834012543	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
266834012544	putative NAD(P) binding site [chemical binding]; other site
266834012545	putative substrate binding site [chemical binding]; other site
266834012546	catalytic Zn binding site [ion binding]; other site
266834012547	structural Zn binding site [ion binding]; other site
266834012548	dimer interface [polypeptide binding]; other site
266834012549	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
266834012550	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834012551	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834012552	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834012553	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
266834012554	putative DNA binding site [nucleotide binding]; other site
266834012555	putative Zn2+ binding site [ion binding]; other site
266834012556	AsnC family; Region: AsnC_trans_reg; pfam01037
266834012557	hypothetical protein; Provisional; Region: PRK06148
266834012558	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
266834012559	active site
266834012560	ATP binding site [chemical binding]; other site
266834012561	Peptidase family M23; Region: Peptidase_M23; pfam01551
266834012562	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834012563	inhibitor-cofactor binding pocket; inhibition site
266834012564	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834012565	catalytic residue [active]
266834012566	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
266834012567	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834012568	substrate binding pocket [chemical binding]; other site
266834012569	membrane-bound complex binding site; other site
266834012570	hinge residues; other site
266834012571	hypothetical protein; Provisional; Region: PRK06149
266834012572	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
266834012573	active site
266834012574	ATP binding site [chemical binding]; other site
266834012575	substrate binding site [chemical binding]; other site
266834012576	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834012577	inhibitor-cofactor binding pocket; inhibition site
266834012578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834012579	catalytic residue [active]
266834012580	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
266834012581	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834012582	DNA-binding site [nucleotide binding]; DNA binding site
266834012583	UTRA domain; Region: UTRA; pfam07702
266834012584	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
266834012585	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
266834012586	active site
266834012587	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
266834012588	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
266834012589	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
266834012590	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834012591	dimer interface [polypeptide binding]; other site
266834012592	conserved gate region; other site
266834012593	ABC-ATPase subunit interface; other site
266834012594	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
266834012595	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
266834012596	Walker A/P-loop; other site
266834012597	ATP binding site [chemical binding]; other site
266834012598	Q-loop/lid; other site
266834012599	ABC transporter signature motif; other site
266834012600	Walker B; other site
266834012601	D-loop; other site
266834012602	H-loop/switch region; other site
266834012603	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
266834012604	active sites [active]
266834012605	tetramer interface [polypeptide binding]; other site
266834012606	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
266834012607	Nucleoside recognition; Region: Gate; pfam07670
266834012608	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758
266834012609	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
266834012610	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
266834012611	Ligand Binding Site [chemical binding]; other site
266834012612	Autoinducer binding domain; Region: Autoind_bind; pfam03472
266834012613	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834012614	DNA binding residues [nucleotide binding]
266834012615	dimerization interface [polypeptide binding]; other site
266834012616	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
266834012617	Predicted acetyltransferase [General function prediction only]; Region: COG2388
266834012618	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834012619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834012620	active site
266834012621	phosphorylation site [posttranslational modification]
266834012622	intermolecular recognition site; other site
266834012623	dimerization interface [polypeptide binding]; other site
266834012624	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834012625	DNA binding site [nucleotide binding]
266834012626	Response regulator receiver domain; Region: Response_reg; pfam00072
266834012627	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834012628	active site
266834012629	phosphorylation site [posttranslational modification]
266834012630	intermolecular recognition site; other site
266834012631	dimerization interface [polypeptide binding]; other site
266834012632	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
266834012633	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400
266834012634	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
266834012635	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
266834012636	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
266834012637	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
266834012638	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
266834012639	RNA binding surface [nucleotide binding]; other site
266834012640	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
266834012641	active site
266834012642	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
266834012643	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
266834012644	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
266834012645	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834012646	DNA binding residues [nucleotide binding]
266834012647	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
266834012648	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
266834012649	GDP-binding site [chemical binding]; other site
266834012650	ACT binding site; other site
266834012651	IMP binding site; other site
266834012652	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
266834012653	EamA-like transporter family; Region: EamA; pfam00892
266834012654	EamA-like transporter family; Region: EamA; pfam00892
266834012655	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
266834012656	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
266834012657	ligand binding site [chemical binding]; other site
266834012658	NAD binding site [chemical binding]; other site
266834012659	dimerization interface [polypeptide binding]; other site
266834012660	catalytic site [active]
266834012661	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
266834012662	putative L-serine binding site [chemical binding]; other site
266834012663	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
266834012664	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
266834012665	catalytic residue [active]
266834012666	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
266834012667	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
266834012668	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
266834012669	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
266834012670	active site
266834012671	substrate binding site [chemical binding]; other site
266834012672	metal binding site [ion binding]; metal-binding site
266834012673	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
266834012674	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834012675	Walker A motif; other site
266834012676	ATP binding site [chemical binding]; other site
266834012677	Walker B motif; other site
266834012678	arginine finger; other site
266834012679	Peptidase family M41; Region: Peptidase_M41; pfam01434
266834012680	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
266834012681	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
266834012682	Ligand Binding Site [chemical binding]; other site
266834012683	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834012684	binding surface
266834012685	Tetratricopeptide repeat; Region: TPR_16; pfam13432
266834012686	TPR motif; other site
266834012687	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
266834012688	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
266834012689	ligand binding site [chemical binding]; other site
266834012690	translocation protein TolB; Provisional; Region: tolB; PRK05137
266834012691	TolB amino-terminal domain; Region: TolB_N; pfam04052
266834012692	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
266834012693	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
266834012694	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
266834012695	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
266834012696	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
266834012697	TolR protein; Region: tolR; TIGR02801
266834012698	TolQ protein; Region: tolQ; TIGR02796
266834012699	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
266834012700	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
266834012701	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
266834012702	active site
266834012703	DNA binding site [nucleotide binding]
266834012704	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
266834012705	DNA binding site [nucleotide binding]
266834012706	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
266834012707	nucleotide binding site [chemical binding]; other site
266834012708	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
266834012709	active site
266834012710	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
266834012711	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834012712	NAD binding site [chemical binding]; other site
266834012713	substrate binding site [chemical binding]; other site
266834012714	active site
266834012715	Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537
266834012716	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
266834012717	substrate binding site; other site
266834012718	Manganese binding site; other site
266834012719	dimer interface; other site
266834012720	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834012721	extended (e) SDRs; Region: SDR_e; cd08946
266834012722	NAD(P) binding site [chemical binding]; other site
266834012723	active site
266834012724	substrate binding site [chemical binding]; other site
266834012725	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
266834012726	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
266834012727	putative active site [active]
266834012728	putative metal binding site [ion binding]; other site
266834012729	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
266834012730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834012731	Walker A motif; other site
266834012732	ATP binding site [chemical binding]; other site
266834012733	Walker B motif; other site
266834012734	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
266834012735	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
266834012736	RuvA N terminal domain; Region: RuvA_N; pfam01330
266834012737	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
266834012738	active site
266834012739	putative DNA-binding cleft [nucleotide binding]; other site
266834012740	dimer interface [polypeptide binding]; other site
266834012741	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
266834012742	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
266834012743	hypothetical protein; Validated; Region: PRK00110
266834012744	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
266834012745	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
266834012746	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
266834012747	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
266834012748	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834012749	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834012750	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
266834012751	putative active site [active]
266834012752	metal binding site [ion binding]; metal-binding site
266834012753	homodimer binding site [polypeptide binding]; other site
266834012754	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
266834012755	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
266834012756	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834012757	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834012758	LysR substrate binding domain; Region: LysR_substrate; pfam03466
266834012759	dimerization interface [polypeptide binding]; other site
266834012760	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
266834012761	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
266834012762	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
266834012763	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
266834012764	TPP-binding site [chemical binding]; other site
266834012765	dimer interface [polypeptide binding]; other site
266834012766	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
266834012767	PYR/PP interface [polypeptide binding]; other site
266834012768	dimer interface [polypeptide binding]; other site
266834012769	TPP binding site [chemical binding]; other site
266834012770	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
266834012771	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
266834012772	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
266834012773	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
266834012774	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554
266834012775	Phosphoglycerate kinase; Region: PGK; pfam00162
266834012776	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
266834012777	substrate binding site [chemical binding]; other site
266834012778	hinge regions; other site
266834012779	ADP binding site [chemical binding]; other site
266834012780	catalytic site [active]
266834012781	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834012782	MULE transposase domain; Region: MULE; pfam10551
266834012783	Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: COG3588
266834012784	catalytic residue [active]
266834012785	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
266834012786	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834012787	cyclase homology domain; Region: CHD; cd07302
266834012788	nucleotidyl binding site; other site
266834012789	metal binding site [ion binding]; metal-binding site
266834012790	dimer interface [polypeptide binding]; other site
266834012791	Predicted integral membrane protein [Function unknown]; Region: COG5616
266834012792	Tetratricopeptide repeat; Region: TPR_12; pfam13424
266834012793	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834012794	TPR motif; other site
266834012795	TPR repeat; Region: TPR_11; pfam13414
266834012796	binding surface
266834012797	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834012798	binding surface
266834012799	TPR motif; other site
266834012800	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834012801	putative substrate translocation pore; other site
266834012802	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
266834012803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317
266834012804	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
266834012805	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
266834012806	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834012807	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
266834012808	Walker A/P-loop; other site
266834012809	ATP binding site [chemical binding]; other site
266834012810	Q-loop/lid; other site
266834012811	ABC transporter signature motif; other site
266834012812	Walker B; other site
266834012813	D-loop; other site
266834012814	H-loop/switch region; other site
266834012815	hypothetical protein; Validated; Region: PRK09039
266834012816	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
266834012817	ligand binding site [chemical binding]; other site
266834012818	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
266834012819	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
266834012820	active site
266834012821	dimerization interface [polypeptide binding]; other site
266834012822	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
266834012823	Sel1-like repeats; Region: SEL1; smart00671
266834012824	Sel1-like repeats; Region: SEL1; smart00671
266834012825	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
266834012826	thiamine phosphate binding site [chemical binding]; other site
266834012827	active site
266834012828	pyrophosphate binding site [ion binding]; other site
266834012829	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
266834012830	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834012831	dimerization interface [polypeptide binding]; other site
266834012832	putative DNA binding site [nucleotide binding]; other site
266834012833	putative Zn2+ binding site [ion binding]; other site
266834012834	Uncharacterized small protein [Function unknown]; Region: COG5570
266834012835	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
266834012836	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
266834012837	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
266834012838	ATP-grasp domain; Region: ATP-grasp; pfam02222
266834012839	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
266834012840	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834012841	TPR repeat; Region: TPR_11; pfam13414
266834012842	binding surface
266834012843	TPR motif; other site
266834012844	pyruvate kinase; Provisional; Region: PRK06247
266834012845	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
266834012846	domain interfaces; other site
266834012847	active site
266834012848	Predicted integral membrane protein [Function unknown]; Region: COG5480
266834012849	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
266834012850	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
266834012851	hypothetical protein; Provisional; Region: PRK13694
266834012852	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
266834012853	Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951
266834012854	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
266834012855	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834012856	active site
266834012857	phosphorylation site [posttranslational modification]
266834012858	intermolecular recognition site; other site
266834012859	dimerization interface [polypeptide binding]; other site
266834012860	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834012861	Walker A motif; other site
266834012862	ATP binding site [chemical binding]; other site
266834012863	Walker B motif; other site
266834012864	arginine finger; other site
266834012865	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
266834012866	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
266834012867	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
266834012868	active site
266834012869	Zn binding site [ion binding]; other site
266834012870	aminodeoxychorismate synthase; Provisional; Region: PRK07508
266834012871	chorismate binding enzyme; Region: Chorismate_bind; cl10555
266834012872	hypothetical protein; Provisional; Region: PRK07546
266834012873	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
266834012874	substrate-cofactor binding pocket; other site
266834012875	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834012876	catalytic residue [active]
266834012877	PAS fold; Region: PAS_7; pfam12860
266834012878	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
266834012879	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834012880	metal binding site [ion binding]; metal-binding site
266834012881	active site
266834012882	I-site; other site
266834012883	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
266834012884	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
266834012885	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
266834012886	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
266834012887	active site
266834012888	metal binding site [ion binding]; metal-binding site
266834012889	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
266834012890	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
266834012891	ferrochelatase; Reviewed; Region: hemH; PRK00035
266834012892	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
266834012893	C-terminal domain interface [polypeptide binding]; other site
266834012894	active site
266834012895	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
266834012896	active site
266834012897	N-terminal domain interface [polypeptide binding]; other site
266834012898	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
266834012899	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
266834012900	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
266834012901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338
266834012902	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
266834012903	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
266834012904	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
266834012905	active site
266834012906	tetramer interface; other site
266834012907	Transglycosylase SLT domain; Region: SLT_2; pfam13406
266834012908	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
266834012909	N-acetyl-D-glucosamine binding site [chemical binding]; other site
266834012910	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834012911	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
266834012912	active site
266834012913	catalytic triad [active]
266834012914	oxyanion hole [active]
266834012915	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
266834012916	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
266834012917	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
266834012918	active site
266834012919	dimer interface [polypeptide binding]; other site
266834012920	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
266834012921	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
266834012922	active site
266834012923	FMN binding site [chemical binding]; other site
266834012924	substrate binding site [chemical binding]; other site
266834012925	3Fe-4S cluster binding site [ion binding]; other site
266834012926	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
266834012927	domain interface; other site
266834012928	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
266834012929	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
266834012930	tetramer interface [polypeptide binding]; other site
266834012931	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834012932	catalytic residue [active]
266834012933	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
266834012934	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
266834012935	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
266834012936	Autoinducer binding domain; Region: Autoind_bind; pfam03472
266834012937	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
266834012938	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834012939	DNA binding residues [nucleotide binding]
266834012940	dimerization interface [polypeptide binding]; other site
266834012941	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
266834012942	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834012943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834012944	dimer interface [polypeptide binding]; other site
266834012945	conserved gate region; other site
266834012946	putative PBP binding loops; other site
266834012947	ABC-ATPase subunit interface; other site
266834012948	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
266834012949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834012950	dimer interface [polypeptide binding]; other site
266834012951	conserved gate region; other site
266834012952	putative PBP binding loops; other site
266834012953	ABC-ATPase subunit interface; other site
266834012954	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
266834012955	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834012956	Walker A/P-loop; other site
266834012957	ATP binding site [chemical binding]; other site
266834012958	Q-loop/lid; other site
266834012959	ABC transporter signature motif; other site
266834012960	Walker B; other site
266834012961	D-loop; other site
266834012962	H-loop/switch region; other site
266834012963	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834012964	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834012965	Walker A/P-loop; other site
266834012966	ATP binding site [chemical binding]; other site
266834012967	Q-loop/lid; other site
266834012968	ABC transporter signature motif; other site
266834012969	Walker B; other site
266834012970	D-loop; other site
266834012971	H-loop/switch region; other site
266834012972	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834012973	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
266834012974	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834012975	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
266834012976	Transposase domain (DUF772); Region: DUF772; pfam05598
266834012977	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
266834012978	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
266834012979	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
266834012980	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
266834012981	putative dimer interface [polypeptide binding]; other site
266834012982	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
266834012983	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
266834012984	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
266834012985	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
266834012986	active site
266834012987	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
266834012988	Response regulator receiver domain; Region: Response_reg; pfam00072
266834012989	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834012990	active site
266834012991	phosphorylation site [posttranslational modification]
266834012992	intermolecular recognition site; other site
266834012993	dimerization interface [polypeptide binding]; other site
266834012994	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
266834012995	Uncharacterized conserved protein [Function unknown]; Region: COG3791
266834012996	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
266834012997	pseudoazurin; Region: pseudoazurin; TIGR02375
266834012998	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
266834012999	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
266834013000	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
266834013001	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
266834013002	Moco binding site; other site
266834013003	metal coordination site [ion binding]; other site
266834013004	dimerization interface [polypeptide binding]; other site
266834013005	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
266834013006	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
266834013007	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
266834013008	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834013009	DNA binding residues [nucleotide binding]
266834013010	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
266834013011	MarR family; Region: MarR; pfam01047
266834013012	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
266834013013	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834013014	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
266834013015	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834013016	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
266834013017	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834013018	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834013019	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834013020	dimerization interface [polypeptide binding]; other site
266834013021	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834013022	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834013023	active site
266834013024	catalytic tetrad [active]
266834013025	Uncharacterized conserved protein [Function unknown]; Region: COG2308
266834013026	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
266834013027	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
266834013028	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
266834013029	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
266834013030	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
266834013031	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
266834013032	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
266834013033	metal ion-dependent adhesion site (MIDAS); other site
266834013034	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
266834013035	homodimer interface [polypeptide binding]; other site
266834013036	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
266834013037	active site pocket [active]
266834013038	glycogen branching enzyme; Provisional; Region: PRK05402
266834013039	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
266834013040	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
266834013041	active site
266834013042	catalytic site [active]
266834013043	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
266834013044	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
266834013045	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
266834013046	ligand binding site; other site
266834013047	oligomer interface; other site
266834013048	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
266834013049	dimer interface [polypeptide binding]; other site
266834013050	N-terminal domain interface [polypeptide binding]; other site
266834013051	sulfate 1 binding site; other site
266834013052	glycogen synthase; Provisional; Region: glgA; PRK00654
266834013053	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
266834013054	ADP-binding pocket [chemical binding]; other site
266834013055	homodimer interface [polypeptide binding]; other site
266834013056	phosphoglucomutase; Region: PLN02307
266834013057	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
266834013058	substrate binding site [chemical binding]; other site
266834013059	dimer interface [polypeptide binding]; other site
266834013060	active site
266834013061	metal binding site [ion binding]; metal-binding site
266834013062	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
266834013063	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
266834013064	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
266834013065	active site
266834013066	catalytic site [active]
266834013067	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
266834013068	putative active site [active]
266834013069	putative catalytic site [active]
266834013070	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427
266834013071	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
266834013072	Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281
266834013073	NAD binding site [chemical binding]; other site
266834013074	catalytic Zn binding site [ion binding]; other site
266834013075	substrate binding site [chemical binding]; other site
266834013076	structural Zn binding site [ion binding]; other site
266834013077	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
266834013078	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
266834013079	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
266834013080	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
266834013081	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
266834013082	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
266834013083	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834013084	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
266834013085	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
266834013086	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
266834013087	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834013088	TPR motif; other site
266834013089	binding surface
266834013090	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834013091	binding surface
266834013092	TPR motif; other site
266834013093	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834013094	binding surface
266834013095	TPR motif; other site
266834013096	Protein of unknown function (DUF992); Region: DUF992; pfam06186
266834013097	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834013098	cyclase homology domain; Region: CHD; cd07302
266834013099	nucleotidyl binding site; other site
266834013100	metal binding site [ion binding]; metal-binding site
266834013101	dimer interface [polypeptide binding]; other site
266834013102	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
266834013103	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
266834013104	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
266834013105	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
266834013106	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
266834013107	ligand binding site [chemical binding]; other site
266834013108	homodimer interface [polypeptide binding]; other site
266834013109	NAD(P) binding site [chemical binding]; other site
266834013110	trimer interface B [polypeptide binding]; other site
266834013111	trimer interface A [polypeptide binding]; other site
266834013112	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
266834013113	PAS domain; Region: PAS; smart00091
266834013114	PAS fold; Region: PAS_7; pfam12860
266834013115	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
266834013116	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834013117	metal binding site [ion binding]; metal-binding site
266834013118	active site
266834013119	I-site; other site
266834013120	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834013121	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
266834013122	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
266834013123	catalytic triad [active]
266834013124	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
266834013125	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
266834013126	putative ligand binding site [chemical binding]; other site
266834013127	NAD binding site [chemical binding]; other site
266834013128	catalytic site [active]
266834013129	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834013130	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834013131	DNA binding site [nucleotide binding]
266834013132	domain linker motif; other site
266834013133	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
266834013134	putative dimerization interface [polypeptide binding]; other site
266834013135	putative ligand binding site [chemical binding]; other site
266834013136	MarR family; Region: MarR_2; cl17246
266834013137	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
266834013138	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
266834013139	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
266834013140	P-loop, Walker A motif; other site
266834013141	Base recognition motif; other site
266834013142	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
266834013143	FOG: WD40 repeat [General function prediction only]; Region: COG2319
266834013144	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
266834013145	structural tetrad; other site
266834013146	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
266834013147	Predicted acetyltransferase [General function prediction only]; Region: COG3153
266834013148	Coenzyme A binding pocket [chemical binding]; other site
266834013149	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
266834013150	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
266834013151	dimer interface [polypeptide binding]; other site
266834013152	active site
266834013153	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
266834013154	catalytic residues [active]
266834013155	substrate binding site [chemical binding]; other site
266834013156	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834013157	LysR family transcriptional regulator; Provisional; Region: PRK14997
266834013158	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834013159	putative effector binding pocket; other site
266834013160	dimerization interface [polypeptide binding]; other site
266834013161	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
266834013162	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
266834013163	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
266834013164	putative active site [active]
266834013165	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
266834013166	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
266834013167	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
266834013168	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
266834013169	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
266834013170	putative metal binding site [ion binding]; other site
266834013171	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
266834013172	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
266834013173	active site
266834013174	intersubunit interface [polypeptide binding]; other site
266834013175	catalytic residue [active]
266834013176	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
266834013177	putative active site [active]
266834013178	putative metal binding residues [ion binding]; other site
266834013179	signature motif; other site
266834013180	putative dimer interface [polypeptide binding]; other site
266834013181	putative phosphate binding site [ion binding]; other site
266834013182	CHAD domain; Region: CHAD; pfam05235
266834013183	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
266834013184	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
266834013185	active site residue [active]
266834013186	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
266834013187	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
266834013188	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834013189	dimer interface [polypeptide binding]; other site
266834013190	conserved gate region; other site
266834013191	ABC-ATPase subunit interface; other site
266834013192	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
266834013193	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
266834013194	Walker A/P-loop; other site
266834013195	ATP binding site [chemical binding]; other site
266834013196	Q-loop/lid; other site
266834013197	ABC transporter signature motif; other site
266834013198	Walker B; other site
266834013199	D-loop; other site
266834013200	H-loop/switch region; other site
266834013201	NIL domain; Region: NIL; pfam09383
266834013202	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
266834013203	beta-galactosidase; Region: BGL; TIGR03356
266834013204	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834013205	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834013206	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
266834013207	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
266834013208	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
266834013209	xylose isomerase; Provisional; Region: PRK05474
266834013210	xylose isomerase; Region: xylose_isom_A; TIGR02630
266834013211	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
266834013212	N- and C-terminal domain interface [polypeptide binding]; other site
266834013213	D-xylulose kinase; Region: XylB; TIGR01312
266834013214	active site
266834013215	MgATP binding site [chemical binding]; other site
266834013216	catalytic site [active]
266834013217	metal binding site [ion binding]; metal-binding site
266834013218	xylulose binding site [chemical binding]; other site
266834013219	homodimer interface [polypeptide binding]; other site
266834013220	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834013221	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834013222	DNA binding site [nucleotide binding]
266834013223	domain linker motif; other site
266834013224	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
266834013225	putative ligand binding site [chemical binding]; other site
266834013226	Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion]; Region: COG5555
266834013227	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
266834013228	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834013229	putative substrate translocation pore; other site
266834013230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834013231	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
266834013232	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834013233	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834013234	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834013235	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834013236	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
266834013237	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834013238	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834013239	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834013240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
266834013241	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
266834013242	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
266834013243	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
266834013244	HIGH motif; other site
266834013245	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
266834013246	active site
266834013247	KMSKS motif; other site
266834013248	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
266834013249	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
266834013250	dimer interface [polypeptide binding]; other site
266834013251	putative anticodon binding site; other site
266834013252	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
266834013253	motif 1; other site
266834013254	active site
266834013255	motif 2; other site
266834013256	motif 3; other site
266834013257	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
266834013258	active site
266834013259	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
266834013260	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
266834013261	ATP-dependent DNA ligase; Validated; Region: PRK09247
266834013262	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
266834013263	active site
266834013264	DNA binding site [nucleotide binding]
266834013265	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
266834013266	DNA binding site [nucleotide binding]
266834013267	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3452
266834013268	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834013269	PAS fold; Region: PAS_3; pfam08447
266834013270	putative active site [active]
266834013271	heme pocket [chemical binding]; other site
266834013272	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
266834013273	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834013274	metal binding site [ion binding]; metal-binding site
266834013275	active site
266834013276	I-site; other site
266834013277	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834013278	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
266834013279	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
266834013280	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
266834013281	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
266834013282	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
266834013283	monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943
266834013284	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
266834013285	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
266834013286	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
266834013287	Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942
266834013288	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
266834013289	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
266834013290	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
266834013291	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
266834013292	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834013293	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834013294	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834013295	putative effector binding pocket; other site
266834013296	dimerization interface [polypeptide binding]; other site
266834013297	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
266834013298	active site
266834013299	SAM binding site [chemical binding]; other site
266834013300	homodimer interface [polypeptide binding]; other site
266834013301	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
266834013302	active site
266834013303	putative homodimer interface [polypeptide binding]; other site
266834013304	SAM binding site [chemical binding]; other site
266834013305	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
266834013306	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
266834013307	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
266834013308	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
266834013309	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
266834013310	active site
266834013311	SAM binding site [chemical binding]; other site
266834013312	homodimer interface [polypeptide binding]; other site
266834013313	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
266834013314	active site
266834013315	SAM binding site [chemical binding]; other site
266834013316	homodimer interface [polypeptide binding]; other site
266834013317	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
266834013318	Precorrin-8X methylmutase; Region: CbiC; pfam02570
266834013319	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
266834013320	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
266834013321	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
266834013322	active site
266834013323	SAM binding site [chemical binding]; other site
266834013324	homodimer interface [polypeptide binding]; other site
266834013325	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
266834013326	ligand binding site [chemical binding]; other site
266834013327	active site
266834013328	UGI interface [polypeptide binding]; other site
266834013329	catalytic site [active]
266834013330	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
266834013331	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
266834013332	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
266834013333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834013334	dimer interface [polypeptide binding]; other site
266834013335	conserved gate region; other site
266834013336	putative PBP binding loops; other site
266834013337	ABC-ATPase subunit interface; other site
266834013338	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834013339	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
266834013340	Walker A/P-loop; other site
266834013341	ATP binding site [chemical binding]; other site
266834013342	Q-loop/lid; other site
266834013343	ABC transporter signature motif; other site
266834013344	Walker B; other site
266834013345	D-loop; other site
266834013346	H-loop/switch region; other site
266834013347	TOBE domain; Region: TOBE; pfam03459
266834013348	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
266834013349	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
266834013350	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834013351	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
266834013352	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
266834013353	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
266834013354	tetramer interface [polypeptide binding]; other site
266834013355	TPP-binding site [chemical binding]; other site
266834013356	heterodimer interface [polypeptide binding]; other site
266834013357	phosphorylation loop region [posttranslational modification]
266834013358	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
266834013359	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
266834013360	alpha subunit interface [polypeptide binding]; other site
266834013361	TPP binding site [chemical binding]; other site
266834013362	heterodimer interface [polypeptide binding]; other site
266834013363	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
266834013364	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
266834013365	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
266834013366	E3 interaction surface; other site
266834013367	lipoyl attachment site [posttranslational modification]; other site
266834013368	e3 binding domain; Region: E3_binding; pfam02817
266834013369	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
266834013370	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
266834013371	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
266834013372	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834013373	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
266834013374	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
266834013375	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
266834013376	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
266834013377	putative active site [active]
266834013378	putative substrate binding site [chemical binding]; other site
266834013379	putative cosubstrate binding site; other site
266834013380	catalytic site [active]
266834013381	maleylacetoacetate isomerase; Region: maiA; TIGR01262
266834013382	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
266834013383	C-terminal domain interface [polypeptide binding]; other site
266834013384	GSH binding site (G-site) [chemical binding]; other site
266834013385	putative dimer interface [polypeptide binding]; other site
266834013386	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
266834013387	dimer interface [polypeptide binding]; other site
266834013388	N-terminal domain interface [polypeptide binding]; other site
266834013389	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
266834013390	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
266834013391	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
266834013392	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
266834013393	Transcriptional regulators [Transcription]; Region: MarR; COG1846
266834013394	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
266834013395	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834013396	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834013397	putative DNA binding site [nucleotide binding]; other site
266834013398	putative Zn2+ binding site [ion binding]; other site
266834013399	AsnC family; Region: AsnC_trans_reg; pfam01037
266834013400	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
266834013401	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
266834013402	dimer interface [polypeptide binding]; other site
266834013403	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
266834013404	active site
266834013405	Fe binding site [ion binding]; other site
266834013406	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
266834013407	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834013408	DNA binding residues [nucleotide binding]
266834013409	dimerization interface [polypeptide binding]; other site
266834013410	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
266834013411	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834013412	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
266834013413	Walker A/P-loop; other site
266834013414	ATP binding site [chemical binding]; other site
266834013415	Q-loop/lid; other site
266834013416	ABC transporter signature motif; other site
266834013417	Walker B; other site
266834013418	D-loop; other site
266834013419	H-loop/switch region; other site
266834013420	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
266834013421	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834013422	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834013423	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834013424	TPR motif; other site
266834013425	binding surface
266834013426	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834013427	binding surface
266834013428	Tetratricopeptide repeat; Region: TPR_16; pfam13432
266834013429	TPR motif; other site
266834013430	Tetratricopeptide repeat; Region: TPR_16; pfam13432
266834013431	Methyltransferase domain; Region: Methyltransf_25; pfam13649
266834013432	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834013433	I-site; other site
266834013434	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834013435	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
266834013436	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834013437	DNA-binding site [nucleotide binding]; DNA binding site
266834013438	UTRA domain; Region: UTRA; pfam07702
266834013439	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
266834013440	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
266834013441	putative active site [active]
266834013442	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
266834013443	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
266834013444	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
266834013445	substrate binding site [chemical binding]; other site
266834013446	ATP binding site [chemical binding]; other site
266834013447	Predicted nucleic-acid-binding protein, contains PIN domain [General function prediction only]; Region: COG5573
266834013448	putative active site [active]
266834013449	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
266834013450	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
266834013451	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
266834013452	Walker A/P-loop; other site
266834013453	ATP binding site [chemical binding]; other site
266834013454	Q-loop/lid; other site
266834013455	ABC transporter signature motif; other site
266834013456	Walker B; other site
266834013457	D-loop; other site
266834013458	H-loop/switch region; other site
266834013459	EamA-like transporter family; Region: EamA; pfam00892
266834013460	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834013461	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834013462	dimer interface [polypeptide binding]; other site
266834013463	conserved gate region; other site
266834013464	putative PBP binding loops; other site
266834013465	ABC-ATPase subunit interface; other site
266834013466	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
266834013467	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834013468	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
266834013469	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834013470	substrate binding pocket [chemical binding]; other site
266834013471	membrane-bound complex binding site; other site
266834013472	hinge residues; other site
266834013473	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
266834013474	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
266834013475	AP (apurinic/apyrimidinic) site pocket; other site
266834013476	DNA interaction; other site
266834013477	Metal-binding active site; metal-binding site
266834013478	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
266834013479	Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565
266834013480	active site
266834013481	catalytic site [active]
266834013482	metal binding site [ion binding]; metal-binding site
266834013483	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
266834013484	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
266834013485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834013486	dimer interface [polypeptide binding]; other site
266834013487	conserved gate region; other site
266834013488	putative PBP binding loops; other site
266834013489	ABC-ATPase subunit interface; other site
266834013490	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834013491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834013492	dimer interface [polypeptide binding]; other site
266834013493	conserved gate region; other site
266834013494	putative PBP binding loops; other site
266834013495	ABC-ATPase subunit interface; other site
266834013496	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
266834013497	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834013498	Walker A/P-loop; other site
266834013499	ATP binding site [chemical binding]; other site
266834013500	Q-loop/lid; other site
266834013501	ABC transporter signature motif; other site
266834013502	Walker B; other site
266834013503	D-loop; other site
266834013504	H-loop/switch region; other site
266834013505	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
266834013506	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
266834013507	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834013508	Walker A/P-loop; other site
266834013509	ATP binding site [chemical binding]; other site
266834013510	Q-loop/lid; other site
266834013511	ABC transporter signature motif; other site
266834013512	Walker B; other site
266834013513	D-loop; other site
266834013514	H-loop/switch region; other site
266834013515	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
266834013516	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834013517	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515
266834013518	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
266834013519	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834013520	DNA binding residues [nucleotide binding]
266834013521	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
266834013522	rrn OR SMc03224; predicted by Homology
266834013523	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834013524	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834013525	LysR substrate binding domain; Region: LysR_substrate; pfam03466
266834013526	dimerization interface [polypeptide binding]; other site
266834013527	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
266834013528	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
266834013529	putative ligand binding site [chemical binding]; other site
266834013530	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
266834013531	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
266834013532	Walker A/P-loop; other site
266834013533	ATP binding site [chemical binding]; other site
266834013534	Q-loop/lid; other site
266834013535	ABC transporter signature motif; other site
266834013536	Walker B; other site
266834013537	D-loop; other site
266834013538	H-loop/switch region; other site
266834013539	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
266834013540	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
266834013541	Walker A/P-loop; other site
266834013542	ATP binding site [chemical binding]; other site
266834013543	Q-loop/lid; other site
266834013544	ABC transporter signature motif; other site
266834013545	Walker B; other site
266834013546	D-loop; other site
266834013547	H-loop/switch region; other site
266834013548	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834013549	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
266834013550	TM-ABC transporter signature motif; other site
266834013551	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
266834013552	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
266834013553	TM-ABC transporter signature motif; other site
266834013554	choline dehydrogenase; Validated; Region: PRK02106
266834013555	lycopene cyclase; Region: lycopene_cycl; TIGR01789
266834013556	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
266834013557	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834013558	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834013559	MULE transposase domain; Region: MULE; pfam10551
266834013560	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834013561	MULE transposase domain; Region: MULE; pfam10551
266834013562	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
266834013563	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
266834013564	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
266834013565	substrate binding pocket [chemical binding]; other site
266834013566	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
266834013567	B12 binding site [chemical binding]; other site
266834013568	cobalt ligand [ion binding]; other site
266834013569	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
266834013570	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
266834013571	dimerization interface [polypeptide binding]; other site
266834013572	putative active cleft [active]
266834013573	hypothetical protein; Provisional; Region: PRK02487
266834013574	fructokinase; Reviewed; Region: PRK09557
266834013575	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
266834013576	nucleotide binding site [chemical binding]; other site
266834013577	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
266834013578	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
266834013579	Predicted periplasmic protein [General function prediction only]; Region: COG3895
266834013580	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
266834013581	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
266834013582	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
266834013583	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
266834013584	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
266834013585	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
266834013586	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
266834013587	substrate-cofactor binding pocket; other site
266834013588	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834013589	catalytic residue [active]
266834013590	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
266834013591	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
266834013592	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
266834013593	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
266834013594	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834013595	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
266834013596	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
266834013597	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834013598	cyclase homology domain; Region: CHD; cd07302
266834013599	nucleotidyl binding site; other site
266834013600	metal binding site [ion binding]; metal-binding site
266834013601	dimer interface [polypeptide binding]; other site
266834013602	Predicted integral membrane protein [Function unknown]; Region: COG5616
266834013603	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
266834013604	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834013605	TPR motif; other site
266834013606	binding surface
266834013607	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
266834013608	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
266834013609	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
266834013610	Surface antigen; Region: Bac_surface_Ag; pfam01103
266834013611	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
266834013612	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
266834013613	Family of unknown function (DUF490); Region: DUF490; pfam04357
266834013614	Family of unknown function (DUF490); Region: DUF490; pfam04357
266834013615	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
266834013616	Phosphotransferase enzyme family; Region: APH; pfam01636
266834013617	active site
266834013618	ATP binding site [chemical binding]; other site
266834013619	antibiotic binding site [chemical binding]; other site
266834013620	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
266834013621	putative dimer interface [polypeptide binding]; other site
266834013622	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834013623	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834013624	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
266834013625	AsnC family; Region: AsnC_trans_reg; pfam01037
266834013626	Arginase family; Region: Arginase; cd09989
266834013627	active site
266834013628	Mn binding site [ion binding]; other site
266834013629	oligomer interface [polypeptide binding]; other site
266834013630	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
266834013631	putative CheA interaction surface; other site
266834013632	DDE superfamily endonuclease; Region: DDE_3; pfam13358
266834013633	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
266834013634	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
266834013635	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
266834013636	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834013637	Homeodomain-like domain; Region: HTH_32; pfam13565
266834013638	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834013639	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
266834013640	putative active site [active]
266834013641	heme pocket [chemical binding]; other site
266834013642	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834013643	putative active site [active]
266834013644	heme pocket [chemical binding]; other site
266834013645	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
266834013646	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
266834013647	dimer interface [polypeptide binding]; other site
266834013648	putative CheW interface [polypeptide binding]; other site
266834013649	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
266834013650	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
266834013651	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
266834013652	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834013653	catalytic loop [active]
266834013654	iron binding site [ion binding]; other site
266834013655	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
266834013656	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
266834013657	[4Fe-4S] binding site [ion binding]; other site
266834013658	molybdopterin cofactor binding site; other site
266834013659	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
266834013660	molybdopterin cofactor binding site; other site
266834013661	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
266834013662	putative dimer interface [polypeptide binding]; other site
266834013663	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
266834013664	SLBB domain; Region: SLBB; pfam10531
266834013665	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
266834013666	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
266834013667	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
266834013668	putative dimer interface [polypeptide binding]; other site
266834013669	[2Fe-2S] cluster binding site [ion binding]; other site
266834013670	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834013671	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834013672	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
266834013673	dimerization interface [polypeptide binding]; other site
266834013674	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
266834013675	classical (c) SDRs; Region: SDR_c; cd05233
266834013676	NAD(P) binding site [chemical binding]; other site
266834013677	active site
266834013678	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
266834013679	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
266834013680	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
266834013681	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
266834013682	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
266834013683	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
266834013684	Walker A/P-loop; other site
266834013685	ATP binding site [chemical binding]; other site
266834013686	Q-loop/lid; other site
266834013687	ABC transporter signature motif; other site
266834013688	Walker B; other site
266834013689	D-loop; other site
266834013690	H-loop/switch region; other site
266834013691	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
266834013692	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
266834013693	Walker A/P-loop; other site
266834013694	ATP binding site [chemical binding]; other site
266834013695	Q-loop/lid; other site
266834013696	ABC transporter signature motif; other site
266834013697	Walker B; other site
266834013698	D-loop; other site
266834013699	H-loop/switch region; other site
266834013700	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834013701	dimer interface [polypeptide binding]; other site
266834013702	conserved gate region; other site
266834013703	putative PBP binding loops; other site
266834013704	ABC-ATPase subunit interface; other site
266834013705	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834013706	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834013707	dimer interface [polypeptide binding]; other site
266834013708	conserved gate region; other site
266834013709	putative PBP binding loops; other site
266834013710	ABC-ATPase subunit interface; other site
266834013711	Predicted small integral membrane protein [Function unknown]; Region: COG5477
266834013712	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834013713	xanthine permease; Region: pbuX; TIGR03173
266834013714	xanthine permease; Region: pbuX; TIGR03173
266834013715	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
266834013716	EamA-like transporter family; Region: EamA; pfam00892
266834013717	EamA-like transporter family; Region: EamA; pfam00892
266834013718	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
266834013719	metal binding site 2 [ion binding]; metal-binding site
266834013720	putative DNA binding helix; other site
266834013721	metal binding site 1 [ion binding]; metal-binding site
266834013722	dimer interface [polypeptide binding]; other site
266834013723	structural Zn2+ binding site [ion binding]; other site
266834013724	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
266834013725	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
266834013726	metal binding site [ion binding]; metal-binding site
266834013727	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
266834013728	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
266834013729	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
266834013730	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
266834013731	ABC-ATPase subunit  interface; other site
266834013732	dimer interface [polypeptide binding]; other site
266834013733	putative PBP binding regions; other site
266834013734	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
266834013735	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
266834013736	ABC-ATPase subunit  interface; other site
266834013737	dimer interface [polypeptide binding]; other site
266834013738	putative PBP binding regions; other site
266834013739	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834013740	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
266834013741	AsnC family; Region: AsnC_trans_reg; pfam01037
266834013742	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
266834013743	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834013744	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
266834013745	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
266834013746	gamma subunit interface [polypeptide binding]; other site
266834013747	epsilon subunit interface [polypeptide binding]; other site
266834013748	LBP interface [polypeptide binding]; other site
266834013749	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
266834013750	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
266834013751	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
266834013752	alpha subunit interaction interface [polypeptide binding]; other site
266834013753	Walker A motif; other site
266834013754	ATP binding site [chemical binding]; other site
266834013755	Walker B motif; other site
266834013756	inhibitor binding site; inhibition site
266834013757	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
266834013758	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
266834013759	core domain interface [polypeptide binding]; other site
266834013760	delta subunit interface [polypeptide binding]; other site
266834013761	epsilon subunit interface [polypeptide binding]; other site
266834013762	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
266834013763	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
266834013764	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
266834013765	beta subunit interaction interface [polypeptide binding]; other site
266834013766	Walker A motif; other site
266834013767	ATP binding site [chemical binding]; other site
266834013768	Walker B motif; other site
266834013769	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
266834013770	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
266834013771	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
266834013772	primosome assembly protein PriA; Validated; Region: PRK05580
266834013773	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
266834013774	ATP binding site [chemical binding]; other site
266834013775	putative Mg++ binding site [ion binding]; other site
266834013776	helicase superfamily c-terminal domain; Region: HELICc; smart00490
266834013777	nucleotide binding region [chemical binding]; other site
266834013778	ATP-binding site [chemical binding]; other site
266834013779	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
266834013780	active site
266834013781	intersubunit interactions; other site
266834013782	catalytic residue [active]
266834013783	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
266834013784	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
266834013785	Tetratricopeptide repeat; Region: TPR_16; pfam13432
266834013786	Protein of unknown function (DUF560); Region: DUF560; pfam04575
266834013787	Predicted ATPase [General function prediction only]; Region: COG4637
266834013788	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834013789	Walker A/P-loop; other site
266834013790	ATP binding site [chemical binding]; other site
266834013791	Putative hemolysin [General function prediction only]; Region: COG3176
266834013792	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
266834013793	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
266834013794	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
266834013795	active site
266834013796	DNA binding site [nucleotide binding]
266834013797	Int/Topo IB signature motif; other site
266834013798	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
266834013799	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
266834013800	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
266834013801	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834013802	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
266834013803	short chain dehydrogenase; Provisional; Region: PRK06123
266834013804	classical (c) SDRs; Region: SDR_c; cd05233
266834013805	NAD(P) binding site [chemical binding]; other site
266834013806	active site
266834013807	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
266834013808	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
266834013809	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
266834013810	E3 interaction surface; other site
266834013811	lipoyl attachment site [posttranslational modification]; other site
266834013812	e3 binding domain; Region: E3_binding; pfam02817
266834013813	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
266834013814	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
266834013815	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
266834013816	TPP-binding site [chemical binding]; other site
266834013817	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
266834013818	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
266834013819	CoA binding domain; Region: CoA_binding; smart00881
266834013820	CoA-ligase; Region: Ligase_CoA; pfam00549
266834013821	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
266834013822	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
266834013823	CoA-ligase; Region: Ligase_CoA; pfam00549
266834013824	malate dehydrogenase; Reviewed; Region: PRK06223
266834013825	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
266834013826	NAD(P) binding site [chemical binding]; other site
266834013827	dimer interface [polypeptide binding]; other site
266834013828	tetramer (dimer of dimers) interface [polypeptide binding]; other site
266834013829	substrate binding site [chemical binding]; other site
266834013830	Predicted ATPase [General function prediction only]; Region: COG1485
266834013831	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
266834013832	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834013833	sequence-specific DNA binding site [nucleotide binding]; other site
266834013834	salt bridge; other site
266834013835	Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549
266834013836	Protease inhibitor Inh; Region: Inh; pfam02974
266834013837	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834013838	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834013839	Walker A/P-loop; other site
266834013840	ATP binding site [chemical binding]; other site
266834013841	Q-loop/lid; other site
266834013842	ABC transporter signature motif; other site
266834013843	Walker B; other site
266834013844	D-loop; other site
266834013845	H-loop/switch region; other site
266834013846	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834013847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834013848	dimer interface [polypeptide binding]; other site
266834013849	conserved gate region; other site
266834013850	putative PBP binding loops; other site
266834013851	ABC-ATPase subunit interface; other site
266834013852	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834013853	dimer interface [polypeptide binding]; other site
266834013854	conserved gate region; other site
266834013855	putative PBP binding loops; other site
266834013856	ABC-ATPase subunit interface; other site
266834013857	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834013858	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834013859	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
266834013860	putative Zn2+ binding site [ion binding]; other site
266834013861	putative DNA binding site [nucleotide binding]; other site
266834013862	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
266834013863	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
266834013864	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834013865	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834013866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828
266834013867	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
266834013868	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
266834013869	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
266834013870	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
266834013871	L-aspartate oxidase; Provisional; Region: PRK06175
266834013872	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
266834013873	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
266834013874	putative SdhC subunit interface [polypeptide binding]; other site
266834013875	putative proximal heme binding site [chemical binding]; other site
266834013876	putative Iron-sulfur protein interface [polypeptide binding]; other site
266834013877	putative proximal quinone binding site; other site
266834013878	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
266834013879	Iron-sulfur protein interface; other site
266834013880	proximal quinone binding site [chemical binding]; other site
266834013881	SdhD (CybS) interface [polypeptide binding]; other site
266834013882	proximal heme binding site [chemical binding]; other site
266834013883	Predicted methyltransferase [General function prediction only]; Region: COG3897
266834013884	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
266834013885	Uncharacterized conserved protein [Function unknown]; Region: COG2947
266834013886	YciI-like protein; Reviewed; Region: PRK12865
266834013887	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
266834013888	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
266834013889	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
266834013890	UGMP family protein; Validated; Region: PRK09604
266834013891	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
266834013892	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
266834013893	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
266834013894	domain interfaces; other site
266834013895	active site
266834013896	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
266834013897	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
266834013898	active site
266834013899	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
266834013900	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
266834013901	HemY protein N-terminus; Region: HemY_N; pfam07219
266834013902	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
266834013903	putative metal binding site [ion binding]; other site
266834013904	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
266834013905	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
266834013906	catalytic triad [active]
266834013907	enterobactin exporter EntS; Provisional; Region: PRK10489
266834013908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834013909	putative substrate translocation pore; other site
266834013910	YGGT family; Region: YGGT; pfam02325
266834013911	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
266834013912	dimer interface [polypeptide binding]; other site
266834013913	substrate binding site [chemical binding]; other site
266834013914	metal binding sites [ion binding]; metal-binding site
266834013915	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
266834013916	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834013917	Coenzyme A binding pocket [chemical binding]; other site
266834013918	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
266834013919	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
266834013920	G1 box; other site
266834013921	putative GEF interaction site [polypeptide binding]; other site
266834013922	GTP/Mg2+ binding site [chemical binding]; other site
266834013923	Switch I region; other site
266834013924	G2 box; other site
266834013925	G3 box; other site
266834013926	Switch II region; other site
266834013927	G4 box; other site
266834013928	G5 box; other site
266834013929	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
266834013930	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
266834013931	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
266834013932	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
266834013933	putative active site [active]
266834013934	putative metal binding site [ion binding]; other site
266834013935	KTSC domain; Region: KTSC; pfam13619
266834013936	amidase; Provisional; Region: PRK07056
266834013937	amidase; Validated; Region: PRK05962
266834013938	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
266834013939	DDE superfamily endonuclease; Region: DDE_3; pfam13358
266834013940	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
266834013941	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
266834013942	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834013943	Homeodomain-like domain; Region: HTH_32; pfam13565
266834013944	integrase; Provisional; Region: PRK09692
266834013945	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
266834013946	active site
266834013947	Int/Topo IB signature motif; other site
266834013948	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
266834013949	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
266834013950	active site
266834013951	DNA binding site [nucleotide binding]
266834013952	Int/Topo IB signature motif; other site
266834013953	putative transposase OrfB; Reviewed; Region: PHA02517
266834013954	HTH-like domain; Region: HTH_21; pfam13276
266834013955	Integrase core domain; Region: rve; pfam00665
266834013956	Integrase core domain; Region: rve_3; pfam13683
266834013957	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834013958	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
266834013959	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834013960	Transposase; Region: HTH_Tnp_1; pfam01527
266834013961	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
266834013962	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
266834013963	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
266834013964	nucleotide binding site [chemical binding]; other site
266834013965	homotetrameric interface [polypeptide binding]; other site
266834013966	putative phosphate binding site [ion binding]; other site
266834013967	putative allosteric binding site; other site
266834013968	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; pfam05118
266834013969	L-proline 3-hydroxylase, C-terminal; Region: Pro_3_hydrox_C; pfam05373
266834013970	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834013971	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
266834013972	Integrase core domain; Region: rve; pfam00665
266834013973	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834013974	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834013975	DNA-binding site [nucleotide binding]; DNA binding site
266834013976	FCD domain; Region: FCD; pfam07729
266834013977	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
266834013978	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
266834013979	inhibitor site; inhibition site
266834013980	active site
266834013981	dimer interface [polypeptide binding]; other site
266834013982	catalytic residue [active]
266834013983	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
266834013984	Transposase domain (DUF772); Region: DUF772; pfam05598
266834013985	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
266834013986	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
266834013987	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
266834013988	active site
266834013989	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834013990	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834013991	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
266834013992	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
266834013993	active site
266834013994	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
266834013995	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834013996	Walker A/P-loop; other site
266834013997	ATP binding site [chemical binding]; other site
266834013998	Q-loop/lid; other site
266834013999	ABC transporter signature motif; other site
266834014000	Walker B; other site
266834014001	D-loop; other site
266834014002	H-loop/switch region; other site
266834014003	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
266834014004	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834014005	Walker A/P-loop; other site
266834014006	ATP binding site [chemical binding]; other site
266834014007	Q-loop/lid; other site
266834014008	ABC transporter signature motif; other site
266834014009	Walker B; other site
266834014010	D-loop; other site
266834014011	H-loop/switch region; other site
266834014012	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
266834014013	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834014014	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
266834014015	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834014016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834014017	dimer interface [polypeptide binding]; other site
266834014018	conserved gate region; other site
266834014019	putative PBP binding loops; other site
266834014020	ABC-ATPase subunit interface; other site
266834014021	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
266834014022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834014023	putative PBP binding loops; other site
266834014024	dimer interface [polypeptide binding]; other site
266834014025	ABC-ATPase subunit interface; other site
266834014026	Transmembrane secretion effector; Region: MFS_3; pfam05977
266834014027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834014028	putative substrate translocation pore; other site
266834014029	Transposase; Region: HTH_Tnp_1; pfam01527
266834014030	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834014031	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834014032	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
266834014033	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
266834014034	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834014035	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
266834014036	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
266834014037	transposase; Validated; Region: PRK08181
266834014038	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834014039	Walker A motif; other site
266834014040	ATP binding site [chemical binding]; other site
266834014041	Integrase core domain; Region: rve; pfam00665
266834014042	Integrase core domain; Region: rve; pfam00665
266834014043	Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5640
266834014044	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
266834014045	active site
266834014046	substrate binding sites [chemical binding]; other site
266834014047	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
266834014048	Divergent AAA domain; Region: AAA_4; pfam04326
266834014049	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
266834014050	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834014051	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
266834014052	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
266834014053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834014054	Transposase; Region: HTH_Tnp_1; cl17663
266834014055	Uncharacterized conserved protein [Function unknown]; Region: COG5586
266834014056	Transposase; Region: HTH_Tnp_1; cl17663
266834014057	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834014058	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
266834014059	HTH-like domain; Region: HTH_21; pfam13276
266834014060	Integrase core domain; Region: rve; pfam00665
266834014061	Integrase core domain; Region: rve_3; pfam13683
266834014062	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
266834014063	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
266834014064	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834014065	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
266834014066	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
266834014067	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
266834014068	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834014069	Transposase; Region: HTH_Tnp_1; pfam01527
266834014070	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834014071	Integrase core domain; Region: rve; pfam00665
266834014072	DEAD-like helicases superfamily; Region: DEXDc; smart00487
266834014073	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
266834014074	DEAD/DEAH box helicase; Region: DEAD; pfam00270
266834014075	ATP binding site [chemical binding]; other site
266834014076	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
266834014077	ATP-binding site [chemical binding]; other site
266834014078	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
266834014079	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
266834014080	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
266834014081	DNA binding site [nucleotide binding]
266834014082	substrate interaction site [chemical binding]; other site
266834014083	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
266834014084	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
266834014085	additional DNA contacts [nucleotide binding]; other site
266834014086	mismatch recognition site; other site
266834014087	active site
266834014088	zinc binding site [ion binding]; other site
266834014089	DNA intercalation site [nucleotide binding]; other site
266834014090	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834014091	radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261
266834014092	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
266834014093	FeS/SAM binding site; other site
266834014094	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
266834014095	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
266834014096	Predicted chitinase [General function prediction only]; Region: COG3179
266834014097	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834014098	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
266834014099	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
266834014100	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
266834014101	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
266834014102	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
266834014103	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
266834014104	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
266834014105	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
266834014106	GTPase CgtA; Reviewed; Region: obgE; PRK12299
266834014107	GTP1/OBG; Region: GTP1_OBG; pfam01018
266834014108	Obg GTPase; Region: Obg; cd01898
266834014109	G1 box; other site
266834014110	GTP/Mg2+ binding site [chemical binding]; other site
266834014111	Switch I region; other site
266834014112	G2 box; other site
266834014113	G3 box; other site
266834014114	Switch II region; other site
266834014115	G4 box; other site
266834014116	G5 box; other site
266834014117	gamma-glutamyl kinase; Provisional; Region: PRK05429
266834014118	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
266834014119	nucleotide binding site [chemical binding]; other site
266834014120	homotetrameric interface [polypeptide binding]; other site
266834014121	putative phosphate binding site [ion binding]; other site
266834014122	putative allosteric binding site; other site
266834014123	PUA domain; Region: PUA; pfam01472
266834014124	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
266834014125	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
266834014126	putative catalytic cysteine [active]
266834014127	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
266834014128	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
266834014129	active site
266834014130	(T/H)XGH motif; other site
266834014131	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
266834014132	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
266834014133	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
266834014134	Peptidase family M23; Region: Peptidase_M23; pfam01551
266834014135	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
266834014136	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
266834014137	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
266834014138	protein binding site [polypeptide binding]; other site
266834014139	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
266834014140	Catalytic dyad [active]
266834014141	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
266834014142	NodB motif; other site
266834014143	putative active site [active]
266834014144	putative catalytic site [active]
266834014145	Zn binding site [ion binding]; other site
266834014146	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
266834014147	putative active site [active]
266834014148	Ap4A binding site [chemical binding]; other site
266834014149	nudix motif; other site
266834014150	putative metal binding site [ion binding]; other site
266834014151	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
266834014152	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
266834014153	heme binding site [chemical binding]; other site
266834014154	ferroxidase pore; other site
266834014155	ferroxidase diiron center [ion binding]; other site
266834014156	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
266834014157	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
266834014158	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
266834014159	putative active site [active]
266834014160	putative PHP Thumb interface [polypeptide binding]; other site
266834014161	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
266834014162	generic binding surface II; other site
266834014163	generic binding surface I; other site
266834014164	DNA Polymerase Y-family; Region: PolY_like; cd03468
266834014165	active site
266834014166	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
266834014167	DNA binding site [nucleotide binding]
266834014168	Uncharacterized conserved protein [Function unknown]; Region: COG4544
266834014169	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
266834014170	Uncharacterized conserved small protein [Function unknown]; Region: COG5515
266834014171	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
266834014172	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
266834014173	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
266834014174	substrate binding site [chemical binding]; other site
266834014175	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
266834014176	homotrimer interaction site [polypeptide binding]; other site
266834014177	putative active site [active]
266834014178	Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897
266834014179	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
266834014180	proposed active site lysine [active]
266834014181	conserved cys residue [active]
266834014182	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
266834014183	active site
266834014184	catalytic residues [active]
266834014185	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
266834014186	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
266834014187	P-loop, Walker A motif; other site
266834014188	Base recognition motif; other site
266834014189	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
266834014190	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
266834014191	putative deacylase active site [active]
266834014192	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
266834014193	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
266834014194	catalytic residues [active]
266834014195	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
266834014196	Uncharacterized conserved protein [Function unknown]; Region: COG2835
266834014197	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
266834014198	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
266834014199	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
266834014200	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
266834014201	active site
266834014202	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
266834014203	catalytic triad [active]
266834014204	dimer interface [polypeptide binding]; other site
266834014205	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
266834014206	Nitrogen regulatory protein P-II; Region: P-II; smart00938
266834014207	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
266834014208	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
266834014209	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
266834014210	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
266834014211	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
266834014212	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
266834014213	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
266834014214	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
266834014215	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
266834014216	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834014217	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834014218	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
266834014219	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
266834014220	ligand binding site [chemical binding]; other site
266834014221	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834014222	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834014223	TM-ABC transporter signature motif; other site
266834014224	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
266834014225	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834014226	Walker A/P-loop; other site
266834014227	ATP binding site [chemical binding]; other site
266834014228	Q-loop/lid; other site
266834014229	ABC transporter signature motif; other site
266834014230	Walker B; other site
266834014231	D-loop; other site
266834014232	H-loop/switch region; other site
266834014233	Transcriptional regulators [Transcription]; Region: MarR; COG1846
266834014234	MarR family; Region: MarR_2; pfam12802
266834014235	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
266834014236	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
266834014237	nucleotide binding site [chemical binding]; other site
266834014238	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
266834014239	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
266834014240	nucleotide binding site [chemical binding]; other site
266834014241	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
266834014242	putative catalytic site [active]
266834014243	putative phosphate binding site [ion binding]; other site
266834014244	active site
266834014245	metal binding site A [ion binding]; metal-binding site
266834014246	DNA binding site [nucleotide binding]
266834014247	putative AP binding site [nucleotide binding]; other site
266834014248	putative metal binding site B [ion binding]; other site
266834014249	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
266834014250	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
266834014251	ligand binding site [chemical binding]; other site
266834014252	flexible hinge region; other site
266834014253	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834014254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834014255	active site
266834014256	phosphorylation site [posttranslational modification]
266834014257	intermolecular recognition site; other site
266834014258	dimerization interface [polypeptide binding]; other site
266834014259	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834014260	DNA binding site [nucleotide binding]
266834014261	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
266834014262	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
266834014263	catalytic core [active]
266834014264	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
266834014265	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
266834014266	substrate binding site [chemical binding]; other site
266834014267	ligand binding site [chemical binding]; other site
266834014268	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
266834014269	MarR family; Region: MarR_2; pfam12802
266834014270	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834014271	Major Facilitator Superfamily; Region: MFS_1; pfam07690
266834014272	putative substrate translocation pore; other site
266834014273	argininosuccinate synthase; Provisional; Region: PRK13820
266834014274	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
266834014275	ANP binding site [chemical binding]; other site
266834014276	Substrate Binding Site II [chemical binding]; other site
266834014277	Substrate Binding Site I [chemical binding]; other site
266834014278	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
266834014279	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
266834014280	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834014281	Walker A/P-loop; other site
266834014282	ATP binding site [chemical binding]; other site
266834014283	Q-loop/lid; other site
266834014284	ABC transporter signature motif; other site
266834014285	Walker B; other site
266834014286	D-loop; other site
266834014287	H-loop/switch region; other site
266834014288	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834014289	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
266834014290	TM-ABC transporter signature motif; other site
266834014291	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
266834014292	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
266834014293	zinc binding site [ion binding]; other site
266834014294	putative ligand binding site [chemical binding]; other site
266834014295	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
266834014296	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
266834014297	FeS/SAM binding site; other site
266834014298	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
266834014299	Uncharacterized conserved protein [Function unknown]; Region: COG3339
266834014300	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
266834014301	aromatic arch; other site
266834014302	DCoH dimer interaction site [polypeptide binding]; other site
266834014303	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
266834014304	DCoH tetramer interaction site [polypeptide binding]; other site
266834014305	substrate binding site [chemical binding]; other site
266834014306	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
266834014307	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
266834014308	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
266834014309	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
266834014310	active site
266834014311	catalytic triad [active]
266834014312	oxyanion hole [active]
266834014313	switch loop; other site
266834014314	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
266834014315	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
266834014316	Walker A/P-loop; other site
266834014317	ATP binding site [chemical binding]; other site
266834014318	Q-loop/lid; other site
266834014319	ABC transporter signature motif; other site
266834014320	Walker B; other site
266834014321	D-loop; other site
266834014322	H-loop/switch region; other site
266834014323	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
266834014324	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
266834014325	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
266834014326	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
266834014327	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834014328	Coenzyme A binding pocket [chemical binding]; other site
266834014329	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
266834014330	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
266834014331	oligomer interface [polypeptide binding]; other site
266834014332	active site residues [active]
266834014333	Uncharacterized conserved protein [Function unknown]; Region: COG3832
266834014334	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834014335	dimerization interface [polypeptide binding]; other site
266834014336	putative DNA binding site [nucleotide binding]; other site
266834014337	putative Zn2+ binding site [ion binding]; other site
266834014338	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
266834014339	Uncharacterized secreted protein [Function unknown]; Region: COG5429
266834014340	aconitate hydratase; Validated; Region: PRK09277
266834014341	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
266834014342	substrate binding site [chemical binding]; other site
266834014343	ligand binding site [chemical binding]; other site
266834014344	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
266834014345	substrate binding site [chemical binding]; other site
266834014346	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
266834014347	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834014348	Walker A/P-loop; other site
266834014349	ATP binding site [chemical binding]; other site
266834014350	Q-loop/lid; other site
266834014351	ABC transporter signature motif; other site
266834014352	Walker B; other site
266834014353	D-loop; other site
266834014354	H-loop/switch region; other site
266834014355	heme exporter protein CcmB; Region: ccmB; TIGR01190
266834014356	heme exporter protein CcmC; Region: ccmC; TIGR01191
266834014357	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
266834014358	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
266834014359	catalytic residues [active]
266834014360	central insert; other site
266834014361	hypothetical protein; Provisional; Region: PRK00944
266834014362	intracellular septation protein A; Reviewed; Region: PRK00259
266834014363	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
266834014364	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
266834014365	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
266834014366	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
266834014367	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
266834014368	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
266834014369	FeS/SAM binding site; other site
266834014370	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
266834014371	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
266834014372	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
266834014373	signal recognition particle protein; Provisional; Region: PRK10867
266834014374	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
266834014375	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
266834014376	P loop; other site
266834014377	GTP binding site [chemical binding]; other site
266834014378	Signal peptide binding domain; Region: SRP_SPB; pfam02978
266834014379	chorismate mutase; Provisional; Region: PRK09239
266834014380	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
266834014381	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
266834014382	RimM N-terminal domain; Region: RimM; pfam01782
266834014383	PRC-barrel domain; Region: PRC; pfam05239
266834014384	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
266834014385	hypothetical protein; Provisional; Region: PRK10621
266834014386	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
266834014387	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
266834014388	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
266834014389	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834014390	substrate binding pocket [chemical binding]; other site
266834014391	membrane-bound complex binding site; other site
266834014392	hinge residues; other site
266834014393	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834014394	dimer interface [polypeptide binding]; other site
266834014395	conserved gate region; other site
266834014396	putative PBP binding loops; other site
266834014397	ABC-ATPase subunit interface; other site
266834014398	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
266834014399	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
266834014400	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
266834014401	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
266834014402	Thiamine pyrophosphokinase; Region: TPK; cd07995
266834014403	active site
266834014404	dimerization interface [polypeptide binding]; other site
266834014405	thiamine binding site [chemical binding]; other site
266834014406	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
266834014407	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
266834014408	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
266834014409	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834014410	ABC-ATPase subunit interface; other site
266834014411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
266834014412	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
266834014413	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834014414	Walker A/P-loop; other site
266834014415	ATP binding site [chemical binding]; other site
266834014416	Q-loop/lid; other site
266834014417	ABC transporter signature motif; other site
266834014418	Walker B; other site
266834014419	D-loop; other site
266834014420	H-loop/switch region; other site
266834014421	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
266834014422	Peptidase family M48; Region: Peptidase_M48; pfam01435
266834014423	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
266834014424	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
266834014425	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
266834014426	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834014427	DNA binding residues [nucleotide binding]
266834014428	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
266834014429	Ferredoxin [Energy production and conversion]; Region: COG1146
266834014430	4Fe-4S binding domain; Region: Fer4; pfam00037
266834014431	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
266834014432	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
266834014433	RNA binding surface [nucleotide binding]; other site
266834014434	DEAD/DEAH box helicase; Region: DEAD; pfam00270
266834014435	ATP binding site [chemical binding]; other site
266834014436	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
266834014437	putative Mg++ binding site [ion binding]; other site
266834014438	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
266834014439	nucleotide binding region [chemical binding]; other site
266834014440	ATP-binding site [chemical binding]; other site
266834014441	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
266834014442	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
266834014443	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
266834014444	NAD(P) binding site [chemical binding]; other site
266834014445	homotetramer interface [polypeptide binding]; other site
266834014446	homodimer interface [polypeptide binding]; other site
266834014447	active site
266834014448	putative acyltransferase; Provisional; Region: PRK05790
266834014449	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
266834014450	dimer interface [polypeptide binding]; other site
266834014451	active site
266834014452	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
266834014453	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
266834014454	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
266834014455	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
266834014456	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
266834014457	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834014458	putative C-terminal domain interface [polypeptide binding]; other site
266834014459	putative GSH binding site (G-site) [chemical binding]; other site
266834014460	putative dimer interface [polypeptide binding]; other site
266834014461	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
266834014462	putative dimer interface [polypeptide binding]; other site
266834014463	putative N-terminal domain interface [polypeptide binding]; other site
266834014464	putative substrate binding pocket (H-site) [chemical binding]; other site
266834014465	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
266834014466	Transglycosylase; Region: Transgly; cl17702
266834014467	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
266834014468	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
266834014469	substrate binding pocket [chemical binding]; other site
266834014470	chain length determination region; other site
266834014471	substrate-Mg2+ binding site; other site
266834014472	catalytic residues [active]
266834014473	aspartate-rich region 1; other site
266834014474	active site lid residues [active]
266834014475	aspartate-rich region 2; other site
266834014476	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
266834014477	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834014478	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834014479	homodimer interface [polypeptide binding]; other site
266834014480	catalytic residue [active]
266834014481	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
266834014482	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
266834014483	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
266834014484	Transposase [DNA replication, recombination, and repair]; Region: COG5433
266834014485	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
266834014486	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
266834014487	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
266834014488	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
266834014489	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834014490	putative substrate translocation pore; other site
266834014491	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
266834014492	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
266834014493	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
266834014494	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
266834014495	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834014496	substrate binding pocket [chemical binding]; other site
266834014497	membrane-bound complex binding site; other site
266834014498	hinge residues; other site
266834014499	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
266834014500	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
266834014501	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
266834014502	Transposase [DNA replication, recombination, and repair]; Region: COG5433
266834014503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834014504	dimer interface [polypeptide binding]; other site
266834014505	conserved gate region; other site
266834014506	putative PBP binding loops; other site
266834014507	ABC-ATPase subunit interface; other site
266834014508	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
266834014509	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834014510	Walker A/P-loop; other site
266834014511	ATP binding site [chemical binding]; other site
266834014512	Q-loop/lid; other site
266834014513	ABC transporter signature motif; other site
266834014514	Walker B; other site
266834014515	D-loop; other site
266834014516	H-loop/switch region; other site
266834014517	pyruvate carboxylase; Reviewed; Region: PRK12999
266834014518	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
266834014519	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
266834014520	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
266834014521	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
266834014522	active site
266834014523	catalytic residues [active]
266834014524	metal binding site [ion binding]; metal-binding site
266834014525	homodimer binding site [polypeptide binding]; other site
266834014526	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
266834014527	carboxyltransferase (CT) interaction site; other site
266834014528	biotinylation site [posttranslational modification]; other site
266834014529	Autoinducer binding domain; Region: Autoind_bind; pfam03472
266834014530	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834014531	DNA binding residues [nucleotide binding]
266834014532	dimerization interface [polypeptide binding]; other site
266834014533	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
266834014534	HTH-like domain; Region: HTH_21; pfam13276
266834014535	Integrase core domain; Region: rve; pfam00665
266834014536	Integrase core domain; Region: rve_3; pfam13683
266834014537	Transposase; Region: HTH_Tnp_1; cl17663
266834014538	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834014539	Autoinducer binding domain; Region: Autoind_bind; pfam03472
266834014540	glucan exporter ATP-binding protein; Region: chvA; TIGR01192
266834014541	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834014542	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
266834014543	Walker A/P-loop; other site
266834014544	ATP binding site [chemical binding]; other site
266834014545	Q-loop/lid; other site
266834014546	ABC transporter signature motif; other site
266834014547	Walker B; other site
266834014548	D-loop; other site
266834014549	H-loop/switch region; other site
266834014550	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645
266834014551	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
266834014552	Putative glucoamylase; Region: Glycoamylase; pfam10091
266834014553	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
266834014554	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
266834014555	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
266834014556	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
266834014557	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834014558	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
266834014559	dimerization interface [polypeptide binding]; other site
266834014560	substrate binding pocket [chemical binding]; other site
266834014561	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
266834014562	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
266834014563	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
266834014564	FAD binding domain; Region: FAD_binding_4; pfam01565
266834014565	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
266834014566	aldehyde dehydrogenase family 7 member; Region: PLN02315
266834014567	tetrameric interface [polypeptide binding]; other site
266834014568	NAD binding site [chemical binding]; other site
266834014569	catalytic residues [active]
266834014570	aspartate aminotransferase; Provisional; Region: PRK05764
266834014571	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834014572	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834014573	homodimer interface [polypeptide binding]; other site
266834014574	catalytic residue [active]
266834014575	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
266834014576	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834014577	non-specific DNA binding site [nucleotide binding]; other site
266834014578	salt bridge; other site
266834014579	sequence-specific DNA binding site [nucleotide binding]; other site
266834014580	Cupin domain; Region: Cupin_2; pfam07883
266834014581	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
266834014582	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834014583	inhibitor-cofactor binding pocket; inhibition site
266834014584	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834014585	catalytic residue [active]
266834014586	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
266834014587	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
266834014588	MOFRL family; Region: MOFRL; pfam05161
266834014589	choline dehydrogenase; Validated; Region: PRK02106
266834014590	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
266834014591	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
266834014592	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834014593	NAD(P) binding site [chemical binding]; other site
266834014594	active site
266834014595	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
266834014596	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
266834014597	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834014598	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834014599	Walker A/P-loop; other site
266834014600	ATP binding site [chemical binding]; other site
266834014601	Q-loop/lid; other site
266834014602	ABC transporter signature motif; other site
266834014603	Walker B; other site
266834014604	D-loop; other site
266834014605	H-loop/switch region; other site
266834014606	TOBE domain; Region: TOBE; cl01440
266834014607	TOBE domain; Region: TOBE_2; pfam08402
266834014608	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834014609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834014610	dimer interface [polypeptide binding]; other site
266834014611	conserved gate region; other site
266834014612	putative PBP binding loops; other site
266834014613	ABC-ATPase subunit interface; other site
266834014614	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834014615	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834014616	dimer interface [polypeptide binding]; other site
266834014617	conserved gate region; other site
266834014618	putative PBP binding loops; other site
266834014619	ABC-ATPase subunit interface; other site
266834014620	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834014621	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
266834014622	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
266834014623	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
266834014624	NAD(P) binding site [chemical binding]; other site
266834014625	catalytic residues [active]
266834014626	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
266834014627	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
266834014628	substrate binding site [chemical binding]; other site
266834014629	oxyanion hole (OAH) forming residues; other site
266834014630	trimer interface [polypeptide binding]; other site
266834014631	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
266834014632	Coenzyme A transferase; Region: CoA_trans; smart00882
266834014633	Coenzyme A transferase; Region: CoA_trans; cl17247
266834014634	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834014635	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834014636	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
266834014637	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834014638	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834014639	DNA binding site [nucleotide binding]
266834014640	domain linker motif; other site
266834014641	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
266834014642	putative dimerization interface [polypeptide binding]; other site
266834014643	putative ligand binding site [chemical binding]; other site
266834014644	Protein of unknown function (DUF993); Region: DUF993; pfam06187
266834014645	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
266834014646	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
266834014647	active site
266834014648	Zn binding site [ion binding]; other site
266834014649	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
266834014650	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
266834014651	tartrate dehydrogenase; Region: TTC; TIGR02089
266834014652	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
266834014653	active site
266834014654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834014655	putative substrate translocation pore; other site
266834014656	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
266834014657	oligomeric interface; other site
266834014658	putative active site [active]
266834014659	homodimer interface [polypeptide binding]; other site
266834014660	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
266834014661	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
266834014662	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
266834014663	Transglycosylase SLT domain; Region: SLT_2; pfam13406
266834014664	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
266834014665	N-acetyl-D-glucosamine binding site [chemical binding]; other site
266834014666	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
266834014667	active site clefts [active]
266834014668	zinc binding site [ion binding]; other site
266834014669	dimer interface [polypeptide binding]; other site
266834014670	pyridoxamine kinase; Validated; Region: PRK05756
266834014671	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
266834014672	pyridoxal binding site [chemical binding]; other site
266834014673	dimer interface [polypeptide binding]; other site
266834014674	ATP binding site [chemical binding]; other site
266834014675	NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902
266834014676	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
266834014677	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
266834014678	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
266834014679	purine monophosphate binding site [chemical binding]; other site
266834014680	dimer interface [polypeptide binding]; other site
266834014681	putative catalytic residues [active]
266834014682	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
266834014683	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360
266834014684	NusB family; Region: NusB; pfam01029
266834014685	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
266834014686	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834014687	S-adenosylmethionine binding site [chemical binding]; other site
266834014688	heat shock protein HtpX; Provisional; Region: PRK01345
266834014689	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
266834014690	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
266834014691	acetyl-CoA synthetase; Provisional; Region: PRK00174
266834014692	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
266834014693	active site
266834014694	CoA binding site [chemical binding]; other site
266834014695	acyl-activating enzyme (AAE) consensus motif; other site
266834014696	AMP binding site [chemical binding]; other site
266834014697	acetate binding site [chemical binding]; other site
266834014698	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
266834014699	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
266834014700	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
266834014701	acyl-activating enzyme (AAE) consensus motif; other site
266834014702	AMP binding site [chemical binding]; other site
266834014703	active site
266834014704	CoA binding site [chemical binding]; other site
266834014705	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
266834014706	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
266834014707	catalytic residue [active]
266834014708	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
266834014709	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
266834014710	HIGH motif; other site
266834014711	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
266834014712	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
266834014713	active site
266834014714	KMSKS motif; other site
266834014715	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
266834014716	tRNA binding surface [nucleotide binding]; other site
266834014717	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468
266834014718	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
266834014719	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
266834014720	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
266834014721	ParB-like nuclease domain; Region: ParBc; pfam02195
266834014722	KorB domain; Region: KorB; pfam08535
266834014723	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
266834014724	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
266834014725	P-loop; other site
266834014726	Magnesium ion binding site [ion binding]; other site
266834014727	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
266834014728	Magnesium ion binding site [ion binding]; other site
266834014729	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
266834014730	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
266834014731	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
266834014732	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
266834014733	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
266834014734	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
266834014735	Predicted GTPase [General function prediction only]; Region: ThdF; COG0486
266834014736	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
266834014737	trmE is a tRNA modification GTPase; Region: trmE; cd04164
266834014738	G1 box; other site
266834014739	GTP/Mg2+ binding site [chemical binding]; other site
266834014740	Switch I region; other site
266834014741	G2 box; other site
266834014742	Switch II region; other site
266834014743	G3 box; other site
266834014744	G4 box; other site
266834014745	G5 box; other site
266834014746	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
266834014747	transcription termination factor Rho; Provisional; Region: rho; PRK09376
266834014748	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
266834014749	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
266834014750	RNA binding site [nucleotide binding]; other site
266834014751	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
266834014752	multimer interface [polypeptide binding]; other site
266834014753	Walker A motif; other site
266834014754	ATP binding site [chemical binding]; other site
266834014755	Walker B motif; other site
266834014756	Predicted membrane protein [Function unknown]; Region: COG1981
266834014757	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
266834014758	substrate binding site [chemical binding]; other site
266834014759	active site
266834014760	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834014761	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834014762	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
266834014763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834014764	putative PBP binding loops; other site
266834014765	ABC-ATPase subunit interface; other site
266834014766	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834014767	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834014768	dimer interface [polypeptide binding]; other site
266834014769	conserved gate region; other site
266834014770	putative PBP binding loops; other site
266834014771	ABC-ATPase subunit interface; other site
266834014772	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
266834014773	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
266834014774	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
266834014775	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
266834014776	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834014777	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834014778	Walker A/P-loop; other site
266834014779	ATP binding site [chemical binding]; other site
266834014780	Q-loop/lid; other site
266834014781	ABC transporter signature motif; other site
266834014782	Walker B; other site
266834014783	D-loop; other site
266834014784	H-loop/switch region; other site
266834014785	TOBE domain; Region: TOBE_2; pfam08402
266834014786	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476
266834014787	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
266834014788	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834014789	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834014790	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
266834014791	putative effector binding pocket; other site
266834014792	putative dimerization interface [polypeptide binding]; other site
266834014793	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834014794	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
266834014795	putative C-terminal domain interface [polypeptide binding]; other site
266834014796	putative GSH binding site (G-site) [chemical binding]; other site
266834014797	putative dimer interface [polypeptide binding]; other site
266834014798	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
266834014799	putative N-terminal domain interface [polypeptide binding]; other site
266834014800	putative dimer interface [polypeptide binding]; other site
266834014801	putative substrate binding pocket (H-site) [chemical binding]; other site
266834014802	Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576
266834014803	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
266834014804	hydroperoxidase II; Provisional; Region: katE; PRK11249
266834014805	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
266834014806	tetramer interface [polypeptide binding]; other site
266834014807	heme binding pocket [chemical binding]; other site
266834014808	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
266834014809	domain interactions; other site
266834014810	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
266834014811	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
266834014812	active site
266834014813	DNA binding site [nucleotide binding]
266834014814	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
266834014815	DNA binding site [nucleotide binding]
266834014816	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834014817	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
266834014818	dimerization interface [polypeptide binding]; other site
266834014819	substrate binding pocket [chemical binding]; other site
266834014820	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
266834014821	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
266834014822	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
266834014823	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
266834014824	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834014825	putative NAD(P) binding site [chemical binding]; other site
266834014826	active site
266834014827	putative substrate binding site [chemical binding]; other site
266834014828	Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919
266834014829	putative active site [active]
266834014830	redox center [active]
266834014831	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834014832	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834014833	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
266834014834	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834014835	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834014836	DNA binding site [nucleotide binding]
266834014837	domain linker motif; other site
266834014838	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
266834014839	dimerization interface [polypeptide binding]; other site
266834014840	ligand binding site [chemical binding]; other site
266834014841	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834014842	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834014843	TM-ABC transporter signature motif; other site
266834014844	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834014845	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834014846	TM-ABC transporter signature motif; other site
266834014847	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834014848	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
266834014849	Walker A/P-loop; other site
266834014850	ATP binding site [chemical binding]; other site
266834014851	Q-loop/lid; other site
266834014852	ABC transporter signature motif; other site
266834014853	Walker B; other site
266834014854	D-loop; other site
266834014855	H-loop/switch region; other site
266834014856	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834014857	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
266834014858	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
266834014859	putative ligand binding site [chemical binding]; other site
266834014860	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
266834014861	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
266834014862	E3 interaction surface; other site
266834014863	lipoyl attachment site [posttranslational modification]; other site
266834014864	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
266834014865	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
266834014866	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
266834014867	tetramer interface [polypeptide binding]; other site
266834014868	TPP-binding site [chemical binding]; other site
266834014869	heterodimer interface [polypeptide binding]; other site
266834014870	phosphorylation loop region [posttranslational modification]
266834014871	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
266834014872	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
266834014873	alpha subunit interface [polypeptide binding]; other site
266834014874	TPP binding site [chemical binding]; other site
266834014875	heterodimer interface [polypeptide binding]; other site
266834014876	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
266834014877	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834014878	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834014879	putative DNA binding site [nucleotide binding]; other site
266834014880	putative Zn2+ binding site [ion binding]; other site
266834014881	AsnC family; Region: AsnC_trans_reg; pfam01037
266834014882	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
266834014883	5-oxoprolinase; Region: PLN02666
266834014884	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
266834014885	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
266834014886	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
266834014887	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
266834014888	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
266834014889	RNA binding surface [nucleotide binding]; other site
266834014890	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
266834014891	active site
266834014892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
266834014893	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
266834014894	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
266834014895	Predicted choloylglycine hydrolase [General function prediction only]; Region: COG4927
266834014896	active site
266834014897	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
266834014898	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
266834014899	Uncharacterized conserved protein [Function unknown]; Region: COG2128
266834014900	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
266834014901	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
266834014902	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
266834014903	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
266834014904	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
266834014905	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
266834014906	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834014907	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
266834014908	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
266834014909	DctM-like transporters; Region: DctM; pfam06808
266834014910	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
266834014911	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
266834014912	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
266834014913	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
266834014914	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
266834014915	shikimate binding site; other site
266834014916	NAD(P) binding site [chemical binding]; other site
266834014917	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
266834014918	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834014919	DNA-binding site [nucleotide binding]; DNA binding site
266834014920	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834014921	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834014922	homodimer interface [polypeptide binding]; other site
266834014923	catalytic residue [active]
266834014924	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
266834014925	EamA-like transporter family; Region: EamA; pfam00892
266834014926	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
266834014927	HTH DNA binding domain; Region: HTH_13; pfam11972
266834014928	replication initiation protein RepC; Provisional; Region: PRK13824
266834014929	Replication protein C N-terminal domain; Region: RP-C; pfam03428
266834014930	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
266834014931	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
266834014932	ParB-like nuclease domain; Region: ParB; smart00470
266834014933	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
266834014934	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
266834014935	P-loop; other site
266834014936	Magnesium ion binding site [ion binding]; other site
266834014937	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
266834014938	Magnesium ion binding site [ion binding]; other site
266834014939	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
266834014940	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834014941	DNA-binding site [nucleotide binding]; DNA binding site
266834014942	UTRA domain; Region: UTRA; pfam07702
266834014943	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
266834014944	elongation factor G; Reviewed; Region: PRK12740
266834014945	G1 box; other site
266834014946	GTP/Mg2+ binding site [chemical binding]; other site
266834014947	G2 box; other site
266834014948	G3 box; other site
266834014949	Switch II region; other site
266834014950	G4 box; other site
266834014951	G5 box; other site
266834014952	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
266834014953	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
266834014954	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
266834014955	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
266834014956	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
266834014957	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
266834014958	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
266834014959	conserved cys residue [active]
266834014960	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834014961	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834014962	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
266834014963	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
266834014964	putative ligand binding residues [chemical binding]; other site
266834014965	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
266834014966	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
266834014967	ABC-ATPase subunit  interface; other site
266834014968	dimer interface [polypeptide binding]; other site
266834014969	putative PBP binding regions; other site
266834014970	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
266834014971	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
266834014972	Walker A/P-loop; other site
266834014973	ATP binding site [chemical binding]; other site
266834014974	Q-loop/lid; other site
266834014975	ABC transporter signature motif; other site
266834014976	Walker B; other site
266834014977	D-loop; other site
266834014978	H-loop/switch region; other site
266834014979	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
266834014980	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834014981	S-adenosylmethionine binding site [chemical binding]; other site
266834014982	Transposase, Mutator family; Region: Transposase_mut; pfam00872
266834014983	MULE transposase domain; Region: MULE; pfam10551
266834014984	3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141
266834014985	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
266834014986	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
266834014987	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
266834014988	ISRm20- OR SMb21606
266834014989	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834014990	Winged helix-turn helix; Region: HTH_29; pfam13551
266834014991	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
266834014992	trimer interface [polypeptide binding]; other site
266834014993	putative Zn binding site [ion binding]; other site
266834014994	Uncharacterized conserved protein [Function unknown]; Region: COG3360
266834014995	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
266834014996	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
266834014997	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
266834014998	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
266834014999	Sulfate transporter family; Region: Sulfate_transp; pfam00916
266834015000	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
266834015001	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
266834015002	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834015003	putative substrate translocation pore; other site
266834015004	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834015005	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
266834015006	putative ligand binding site [chemical binding]; other site
266834015007	short chain dehydrogenase; Provisional; Region: PRK06701
266834015008	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
266834015009	NAD binding site [chemical binding]; other site
266834015010	metal binding site [ion binding]; metal-binding site
266834015011	active site
266834015012	short chain dehydrogenase; Provisional; Region: PRK06139
266834015013	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
266834015014	putative NAD(P) binding site [chemical binding]; other site
266834015015	active site
266834015016	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
266834015017	Histidine kinase; Region: HisKA_3; pfam07730
266834015018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834015019	ATP binding site [chemical binding]; other site
266834015020	Mg2+ binding site [ion binding]; other site
266834015021	G-X-G motif; other site
266834015022	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
266834015023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834015024	active site
266834015025	phosphorylation site [posttranslational modification]
266834015026	intermolecular recognition site; other site
266834015027	dimerization interface [polypeptide binding]; other site
266834015028	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834015029	DNA binding residues [nucleotide binding]
266834015030	dimerization interface [polypeptide binding]; other site
266834015031	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
266834015032	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
266834015033	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
266834015034	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
266834015035	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
266834015036	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
266834015037	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
266834015038	NAD binding site [chemical binding]; other site
266834015039	catalytic Zn binding site [ion binding]; other site
266834015040	structural Zn binding site [ion binding]; other site
266834015041	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
266834015042	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
266834015043	active site
266834015044	metal binding site [ion binding]; metal-binding site
266834015045	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
266834015046	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
266834015047	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834015048	S-adenosylmethionine binding site [chemical binding]; other site
266834015049	Erythromycin esterase; Region: Erythro_esteras; pfam05139
266834015050	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
266834015051	dinuclear metal binding motif [ion binding]; other site
266834015052	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
266834015053	putative catalytic site [active]
266834015054	putative metal binding site [ion binding]; other site
266834015055	putative phosphate binding site [ion binding]; other site
266834015056	Predicted integral membrane protein [Function unknown]; Region: COG0392
266834015057	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
266834015058	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
266834015059	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
266834015060	putative active site [active]
266834015061	putative active site [active]
266834015062	catalytic site [active]
266834015063	catalytic site [active]
266834015064	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
266834015065	putative active site [active]
266834015066	catalytic site [active]
266834015067	thiamine pyrophosphate protein; Provisional; Region: PRK08273
266834015068	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
266834015069	PYR/PP interface [polypeptide binding]; other site
266834015070	dimer interface [polypeptide binding]; other site
266834015071	tetramer interface [polypeptide binding]; other site
266834015072	TPP binding site [chemical binding]; other site
266834015073	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
266834015074	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
266834015075	TPP-binding site [chemical binding]; other site
266834015076	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4288
266834015077	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
266834015078	FAD binding domain; Region: FAD_binding_4; pfam01565
266834015079	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
266834015080	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4288
266834015081	trehalose synthase; Region: treS_nterm; TIGR02456
266834015082	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
266834015083	active site
266834015084	catalytic site [active]
266834015085	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
266834015086	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
266834015087	Predicted dehydrogenase [General function prediction only]; Region: COG0579
266834015088	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834015089	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
266834015090	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834015091	Walker A motif; other site
266834015092	ATP binding site [chemical binding]; other site
266834015093	Walker B motif; other site
266834015094	arginine finger; other site
266834015095	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
266834015096	SnoaL-like domain; Region: SnoaL_2; pfam12680
266834015097	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
266834015098	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
266834015099	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
266834015100	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834015101	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834015102	DNA-binding site [nucleotide binding]; DNA binding site
266834015103	FCD domain; Region: FCD; pfam07729
266834015104	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834015105	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834015106	DNA-binding site [nucleotide binding]; DNA binding site
266834015107	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
266834015108	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
266834015109	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
266834015110	inhibitor site; inhibition site
266834015111	active site
266834015112	dimer interface [polypeptide binding]; other site
266834015113	catalytic residue [active]
266834015114	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834015115	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491
266834015116	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834015117	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015118	dimer interface [polypeptide binding]; other site
266834015119	conserved gate region; other site
266834015120	putative PBP binding loops; other site
266834015121	ABC-ATPase subunit interface; other site
266834015122	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
266834015123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015124	dimer interface [polypeptide binding]; other site
266834015125	conserved gate region; other site
266834015126	putative PBP binding loops; other site
266834015127	ABC-ATPase subunit interface; other site
266834015128	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
266834015129	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834015130	Walker A/P-loop; other site
266834015131	ATP binding site [chemical binding]; other site
266834015132	Q-loop/lid; other site
266834015133	ABC transporter signature motif; other site
266834015134	Walker B; other site
266834015135	D-loop; other site
266834015136	H-loop/switch region; other site
266834015137	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834015138	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834015139	Walker A/P-loop; other site
266834015140	ATP binding site [chemical binding]; other site
266834015141	Q-loop/lid; other site
266834015142	ABC transporter signature motif; other site
266834015143	Walker B; other site
266834015144	D-loop; other site
266834015145	H-loop/switch region; other site
266834015146	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834015147	EamA-like transporter family; Region: EamA; pfam00892
266834015148	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
266834015149	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
266834015150	putative ligand binding site [chemical binding]; other site
266834015151	NAD binding site [chemical binding]; other site
266834015152	catalytic site [active]
266834015153	hypothetical protein; Validated; Region: PRK08245
266834015154	dihydroxy-acid dehydratase; Provisional; Region: PRK13016
266834015155	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
266834015156	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
266834015157	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
266834015158	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834015159	putative ADP-binding pocket [chemical binding]; other site
266834015160	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
266834015161	homotrimer interaction site [polypeptide binding]; other site
266834015162	putative active site [active]
266834015163	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
266834015164	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
266834015165	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
266834015166	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
266834015167	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834015168	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834015169	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
266834015170	putative dimerization interface [polypeptide binding]; other site
266834015171	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
266834015172	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834015173	Walker A/P-loop; other site
266834015174	ATP binding site [chemical binding]; other site
266834015175	Q-loop/lid; other site
266834015176	ABC transporter signature motif; other site
266834015177	Walker B; other site
266834015178	D-loop; other site
266834015179	H-loop/switch region; other site
266834015180	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834015181	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834015182	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
266834015183	TM-ABC transporter signature motif; other site
266834015184	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834015185	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
266834015186	TM-ABC transporter signature motif; other site
266834015187	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
266834015188	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
266834015189	putative ligand binding site [chemical binding]; other site
266834015190	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
266834015191	cytosine deaminase; Provisional; Region: PRK05985
266834015192	active site
266834015193	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834015194	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
266834015195	DNA-binding site [nucleotide binding]; DNA binding site
266834015196	FCD domain; Region: FCD; pfam07729
266834015197	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
266834015198	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
266834015199	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
266834015200	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834015201	catalytic loop [active]
266834015202	iron binding site [ion binding]; other site
266834015203	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
266834015204	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
266834015205	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
266834015206	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834015207	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
266834015208	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
266834015209	P-loop, Walker A motif; other site
266834015210	Base recognition motif; other site
266834015211	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
266834015212	xanthine permease; Region: pbuX; TIGR03173
266834015213	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
266834015214	Flavoprotein; Region: Flavoprotein; pfam02441
266834015215	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
266834015216	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
266834015217	active site
266834015218	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
266834015219	active site
266834015220	Predicted membrane protein [Function unknown]; Region: COG4329
266834015221	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
266834015222	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
266834015223	inhibitor site; inhibition site
266834015224	active site
266834015225	dimer interface [polypeptide binding]; other site
266834015226	catalytic residue [active]
266834015227	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
266834015228	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834015229	Walker A/P-loop; other site
266834015230	ATP binding site [chemical binding]; other site
266834015231	Q-loop/lid; other site
266834015232	ABC transporter signature motif; other site
266834015233	Walker B; other site
266834015234	D-loop; other site
266834015235	H-loop/switch region; other site
266834015236	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834015237	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834015238	Walker A/P-loop; other site
266834015239	ATP binding site [chemical binding]; other site
266834015240	Q-loop/lid; other site
266834015241	ABC transporter signature motif; other site
266834015242	Walker B; other site
266834015243	D-loop; other site
266834015244	H-loop/switch region; other site
266834015245	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834015246	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
266834015247	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
266834015248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015249	dimer interface [polypeptide binding]; other site
266834015250	conserved gate region; other site
266834015251	putative PBP binding loops; other site
266834015252	ABC-ATPase subunit interface; other site
266834015253	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834015254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015255	dimer interface [polypeptide binding]; other site
266834015256	conserved gate region; other site
266834015257	putative PBP binding loops; other site
266834015258	ABC-ATPase subunit interface; other site
266834015259	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834015260	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491
266834015261	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
266834015262	BNR repeat-like domain; Region: BNR_2; pfam13088
266834015263	Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995
266834015264	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
266834015265	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
266834015266	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
266834015267	putative active site [active]
266834015268	metal binding site [ion binding]; metal-binding site
266834015269	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834015270	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834015271	DNA-binding site [nucleotide binding]; DNA binding site
266834015272	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
266834015273	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
266834015274	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
266834015275	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
266834015276	active site
266834015277	dimerization interface [polypeptide binding]; other site
266834015278	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
266834015279	active site
266834015280	catalytic residues [active]
266834015281	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
266834015282	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
266834015283	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
266834015284	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
266834015285	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
266834015286	PhoU domain; Region: PhoU; pfam01895
266834015287	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834015288	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834015289	DNA binding site [nucleotide binding]
266834015290	domain linker motif; other site
266834015291	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
266834015292	putative dimerization interface [polypeptide binding]; other site
266834015293	putative ligand binding site [chemical binding]; other site
266834015294	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
266834015295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015296	dimer interface [polypeptide binding]; other site
266834015297	conserved gate region; other site
266834015298	putative PBP binding loops; other site
266834015299	ABC-ATPase subunit interface; other site
266834015300	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015301	dimer interface [polypeptide binding]; other site
266834015302	conserved gate region; other site
266834015303	putative PBP binding loops; other site
266834015304	ABC-ATPase subunit interface; other site
266834015305	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
266834015306	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834015307	Walker A/P-loop; other site
266834015308	ATP binding site [chemical binding]; other site
266834015309	Q-loop/lid; other site
266834015310	ABC transporter signature motif; other site
266834015311	Walker B; other site
266834015312	D-loop; other site
266834015313	H-loop/switch region; other site
266834015314	TOBE domain; Region: TOBE_2; pfam08402
266834015315	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
266834015316	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
266834015317	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
266834015318	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
266834015319	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
266834015320	active site
266834015321	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
266834015322	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
266834015323	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
266834015324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834015325	active site
266834015326	phosphorylation site [posttranslational modification]
266834015327	intermolecular recognition site; other site
266834015328	dimerization interface [polypeptide binding]; other site
266834015329	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834015330	DNA binding residues [nucleotide binding]
266834015331	dimerization interface [polypeptide binding]; other site
266834015332	Uncharacterized conserved protein [Function unknown]; Region: COG3287
266834015333	FIST N domain; Region: FIST; pfam08495
266834015334	FIST C domain; Region: FIST_C; pfam10442
266834015335	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
266834015336	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834015337	dimer interface [polypeptide binding]; other site
266834015338	phosphorylation site [posttranslational modification]
266834015339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834015340	ATP binding site [chemical binding]; other site
266834015341	Mg2+ binding site [ion binding]; other site
266834015342	G-X-G motif; other site
266834015343	Response regulator receiver domain; Region: Response_reg; pfam00072
266834015344	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834015345	active site
266834015346	phosphorylation site [posttranslational modification]
266834015347	intermolecular recognition site; other site
266834015348	dimerization interface [polypeptide binding]; other site
266834015349	Predicted secreted protein [Function unknown]; Region: COG5501
266834015350	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
266834015351	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
266834015352	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
266834015353	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
266834015354	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
266834015355	substrate binding site [chemical binding]; other site
266834015356	catalytic Zn binding site [ion binding]; other site
266834015357	NAD binding site [chemical binding]; other site
266834015358	structural Zn binding site [ion binding]; other site
266834015359	dimer interface [polypeptide binding]; other site
266834015360	S-formylglutathione hydrolase; Region: PLN02442
266834015361	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
266834015362	Cytochrome c2 [Energy production and conversion]; Region: COG3474
266834015363	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
266834015364	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
266834015365	Trp docking motif [polypeptide binding]; other site
266834015366	dimer interface [polypeptide binding]; other site
266834015367	active site
266834015368	small subunit binding site [polypeptide binding]; other site
266834015369	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
266834015370	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
266834015371	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
266834015372	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834015373	substrate binding pocket [chemical binding]; other site
266834015374	membrane-bound complex binding site; other site
266834015375	hinge residues; other site
266834015376	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
266834015377	active site residue [active]
266834015378	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
266834015379	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
266834015380	ligand binding site [chemical binding]; other site
266834015381	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
266834015382	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
266834015383	structural tetrad; other site
266834015384	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
266834015385	NMT1/THI5 like; Region: NMT1; pfam09084
266834015386	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
266834015387	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
266834015388	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015389	dimer interface [polypeptide binding]; other site
266834015390	conserved gate region; other site
266834015391	putative PBP binding loops; other site
266834015392	ABC-ATPase subunit interface; other site
266834015393	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
266834015394	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834015395	Walker A/P-loop; other site
266834015396	ATP binding site [chemical binding]; other site
266834015397	Q-loop/lid; other site
266834015398	ABC transporter signature motif; other site
266834015399	Walker B; other site
266834015400	D-loop; other site
266834015401	H-loop/switch region; other site
266834015402	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
266834015403	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834015404	Walker A/P-loop; other site
266834015405	ATP binding site [chemical binding]; other site
266834015406	Q-loop/lid; other site
266834015407	ABC transporter signature motif; other site
266834015408	Walker B; other site
266834015409	D-loop; other site
266834015410	H-loop/switch region; other site
266834015411	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
266834015412	alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861
266834015413	glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417
266834015414	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
266834015415	putative catalytic residue [active]
266834015416	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
266834015417	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
266834015418	substrate binding site [chemical binding]; other site
266834015419	hexamer interface [polypeptide binding]; other site
266834015420	metal binding site [ion binding]; metal-binding site
266834015421	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
266834015422	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834015423	Walker A motif; other site
266834015424	ATP binding site [chemical binding]; other site
266834015425	Walker B motif; other site
266834015426	arginine finger; other site
266834015427	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
266834015428	multimerization interface [polypeptide binding]; other site
266834015429	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
266834015430	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
266834015431	homodimer interface [polypeptide binding]; other site
266834015432	active site
266834015433	heterodimer interface [polypeptide binding]; other site
266834015434	catalytic residue [active]
266834015435	metal binding site [ion binding]; metal-binding site
266834015436	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
266834015437	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
266834015438	intersubunit interface [polypeptide binding]; other site
266834015439	active site
266834015440	zinc binding site [ion binding]; other site
266834015441	Na+ binding site [ion binding]; other site
266834015442	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
266834015443	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
266834015444	TPP-binding site [chemical binding]; other site
266834015445	dimer interface [polypeptide binding]; other site
266834015446	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
266834015447	PYR/PP interface [polypeptide binding]; other site
266834015448	dimer interface [polypeptide binding]; other site
266834015449	TPP binding site [chemical binding]; other site
266834015450	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
266834015451	phosphoribulokinase; Provisional; Region: PRK15453
266834015452	fructose-1,6-bisphosphatase family protein; Region: PLN02628
266834015453	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
266834015454	AMP binding site [chemical binding]; other site
266834015455	metal binding site [ion binding]; metal-binding site
266834015456	active site
266834015457	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834015458	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834015459	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
266834015460	putative dimerization interface [polypeptide binding]; other site
266834015461	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
266834015462	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
266834015463	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
266834015464	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
266834015465	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
266834015466	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
266834015467	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
266834015468	FeS/SAM binding site; other site
266834015469	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
266834015470	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
266834015471	active site 1 [active]
266834015472	dimer interface [polypeptide binding]; other site
266834015473	hexamer interface [polypeptide binding]; other site
266834015474	active site 2 [active]
266834015475	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
266834015476	classical (c) SDRs; Region: SDR_c; cd05233
266834015477	NAD(P) binding site [chemical binding]; other site
266834015478	active site
266834015479	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834015480	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834015481	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
266834015482	putative effector binding pocket; other site
266834015483	putative dimerization interface [polypeptide binding]; other site
266834015484	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
266834015485	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
266834015486	potential catalytic triad [active]
266834015487	conserved cys residue [active]
266834015488	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
266834015489	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
266834015490	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
266834015491	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
266834015492	catalytic residues [active]
266834015493	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
266834015494	classical (c) SDRs; Region: SDR_c; cd05233
266834015495	NAD(P) binding site [chemical binding]; other site
266834015496	active site
266834015497	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
266834015498	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
266834015499	conserved cys residue [active]
266834015500	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834015501	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
266834015502	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
266834015503	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
266834015504	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834015505	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
266834015506	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
266834015507	dimer interface [polypeptide binding]; other site
266834015508	phosphorylation site [posttranslational modification]
266834015509	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834015510	ATP binding site [chemical binding]; other site
266834015511	Mg2+ binding site [ion binding]; other site
266834015512	G-X-G motif; other site
266834015513	osmolarity response regulator; Provisional; Region: ompR; PRK09468
266834015514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834015515	active site
266834015516	phosphorylation site [posttranslational modification]
266834015517	intermolecular recognition site; other site
266834015518	dimerization interface [polypeptide binding]; other site
266834015519	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834015520	DNA binding site [nucleotide binding]
266834015521	Epoxide hydrolase N terminus; Region: EHN; pfam06441
266834015522	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
266834015523	Cupin domain; Region: Cupin_2; pfam07883
266834015524	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
266834015525	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
266834015526	BON domain; Region: BON; pfam04972
266834015527	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
266834015528	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
266834015529	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834015530	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834015531	DNA binding site [nucleotide binding]
266834015532	domain linker motif; other site
266834015533	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
266834015534	dimerization interface [polypeptide binding]; other site
266834015535	ligand binding site [chemical binding]; other site
266834015536	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834015537	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834015538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
266834015539	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015540	ABC-ATPase subunit interface; other site
266834015541	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834015542	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015543	dimer interface [polypeptide binding]; other site
266834015544	conserved gate region; other site
266834015545	putative PBP binding loops; other site
266834015546	ABC-ATPase subunit interface; other site
266834015547	Protein of unknown function (DUF2961); Region: DUF2961; pfam11175
266834015548	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834015549	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834015550	Walker A/P-loop; other site
266834015551	ATP binding site [chemical binding]; other site
266834015552	Q-loop/lid; other site
266834015553	ABC transporter signature motif; other site
266834015554	Walker B; other site
266834015555	D-loop; other site
266834015556	H-loop/switch region; other site
266834015557	TOBE domain; Region: TOBE_2; pfam08402
266834015558	Methyltransferase domain; Region: Methyltransf_23; pfam13489
266834015559	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834015560	S-adenosylmethionine binding site [chemical binding]; other site
266834015561	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
266834015562	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834015563	NAD binding site [chemical binding]; other site
266834015564	putative substrate binding site 2 [chemical binding]; other site
266834015565	putative substrate binding site 1 [chemical binding]; other site
266834015566	active site
266834015567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
266834015568	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
266834015569	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
266834015570	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
266834015571	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
266834015572	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
266834015573	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
266834015574	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834015575	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
266834015576	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834015577	NAD binding site [chemical binding]; other site
266834015578	homotetramer interface [polypeptide binding]; other site
266834015579	homodimer interface [polypeptide binding]; other site
266834015580	active site
266834015581	substrate binding site [chemical binding]; other site
266834015582	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834015583	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834015584	NAD(P) binding site [chemical binding]; other site
266834015585	active site
266834015586	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
266834015587	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269
266834015588	putative NAD(P) binding site [chemical binding]; other site
266834015589	catalytic Zn binding site [ion binding]; other site
266834015590	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834015591	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834015592	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
266834015593	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
266834015594	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
266834015595	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
266834015596	catalytic core [active]
266834015597	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
266834015598	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
266834015599	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
266834015600	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
266834015601	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
266834015602	Predicted membrane protein [Function unknown]; Region: COG4420
266834015603	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
266834015604	putative hydrophobic ligand binding site [chemical binding]; other site
266834015605	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834015606	cyclase homology domain; Region: CHD; cd07302
266834015607	nucleotidyl binding site; other site
266834015608	metal binding site [ion binding]; metal-binding site
266834015609	dimer interface [polypeptide binding]; other site
266834015610	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834015611	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834015612	DNA-binding site [nucleotide binding]; DNA binding site
266834015613	FCD domain; Region: FCD; pfam07729
266834015614	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
266834015615	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
266834015616	inhibitor site; inhibition site
266834015617	active site
266834015618	dimer interface [polypeptide binding]; other site
266834015619	catalytic residue [active]
266834015620	Uncharacterized conserved protein [Function unknown]; Region: COG3339
266834015621	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
266834015622	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
266834015623	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
266834015624	dimer interface [polypeptide binding]; other site
266834015625	NADP binding site [chemical binding]; other site
266834015626	catalytic residues [active]
266834015627	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
266834015628	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834015629	substrate binding pocket [chemical binding]; other site
266834015630	membrane-bound complex binding site; other site
266834015631	hinge residues; other site
266834015632	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834015633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015634	dimer interface [polypeptide binding]; other site
266834015635	conserved gate region; other site
266834015636	putative PBP binding loops; other site
266834015637	ABC-ATPase subunit interface; other site
266834015638	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015639	dimer interface [polypeptide binding]; other site
266834015640	conserved gate region; other site
266834015641	putative PBP binding loops; other site
266834015642	ABC-ATPase subunit interface; other site
266834015643	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
266834015644	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
266834015645	Walker A/P-loop; other site
266834015646	ATP binding site [chemical binding]; other site
266834015647	Q-loop/lid; other site
266834015648	ABC transporter signature motif; other site
266834015649	Walker B; other site
266834015650	D-loop; other site
266834015651	H-loop/switch region; other site
266834015652	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
266834015653	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
266834015654	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834015655	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
266834015656	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
266834015657	Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356
266834015658	substrate binding site [chemical binding]; other site
266834015659	Protein of unknown function (DUF521); Region: DUF521; pfam04412
266834015660	Putative Aconitase X catalytic domain; Region: AcnX; cd01355
266834015661	substrate binding site [chemical binding]; other site
266834015662	ligand binding site [chemical binding]; other site
266834015663	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
266834015664	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
266834015665	OsmC-like protein; Region: OsmC; cl00767
266834015666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834015667	Major Facilitator Superfamily; Region: MFS_1; pfam07690
266834015668	putative substrate translocation pore; other site
266834015669	Uncharacterized conserved protein [Function unknown]; Region: COG3246
266834015670	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
266834015671	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
266834015672	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
266834015673	putative active site [active]
266834015674	hypothetical protein; Provisional; Region: PRK07483
266834015675	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834015676	inhibitor-cofactor binding pocket; inhibition site
266834015677	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834015678	catalytic residue [active]
266834015679	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
266834015680	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
266834015681	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950
266834015682	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
266834015683	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
266834015684	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
266834015685	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
266834015686	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
266834015687	Walker A/P-loop; other site
266834015688	ATP binding site [chemical binding]; other site
266834015689	Q-loop/lid; other site
266834015690	ABC transporter signature motif; other site
266834015691	Walker B; other site
266834015692	D-loop; other site
266834015693	H-loop/switch region; other site
266834015694	TOBE domain; Region: TOBE_2; pfam08402
266834015695	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834015696	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015697	dimer interface [polypeptide binding]; other site
266834015698	conserved gate region; other site
266834015699	putative PBP binding loops; other site
266834015700	ABC-ATPase subunit interface; other site
266834015701	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
266834015702	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015703	ABC-ATPase subunit interface; other site
266834015704	putative PBP binding loops; other site
266834015705	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
266834015706	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
266834015707	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834015708	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834015709	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834015710	dimerization interface [polypeptide binding]; other site
266834015711	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
266834015712	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
266834015713	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
266834015714	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
266834015715	active site
266834015716	putative substrate binding pocket [chemical binding]; other site
266834015717	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
266834015718	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834015719	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834015720	DNA binding site [nucleotide binding]
266834015721	domain linker motif; other site
266834015722	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287
266834015723	putative dimerization interface [polypeptide binding]; other site
266834015724	putative ligand binding site [chemical binding]; other site
266834015725	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
266834015726	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
266834015727	Domain of unknown function (DUF3394); Region: DUF3394; pfam11874
266834015728	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
266834015729	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
266834015730	transcriptional regulator NanR; Provisional; Region: PRK03837
266834015731	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834015732	DNA-binding site [nucleotide binding]; DNA binding site
266834015733	FCD domain; Region: FCD; pfam07729
266834015734	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
266834015735	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
266834015736	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
266834015737	DctM-like transporters; Region: DctM; pfam06808
266834015738	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
266834015739	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
266834015740	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
266834015741	inhibitor site; inhibition site
266834015742	active site
266834015743	dimer interface [polypeptide binding]; other site
266834015744	catalytic residue [active]
266834015745	N-acetylneuraminate lyase; Provisional; Region: PRK04147
266834015746	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
266834015747	inhibitor site; inhibition site
266834015748	active site
266834015749	dimer interface [polypeptide binding]; other site
266834015750	catalytic residue [active]
266834015751	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834015752	cyclase homology domain; Region: CHD; cd07302
266834015753	nucleotidyl binding site; other site
266834015754	metal binding site [ion binding]; metal-binding site
266834015755	dimer interface [polypeptide binding]; other site
266834015756	Predicted integral membrane protein [Function unknown]; Region: COG5616
266834015757	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834015758	binding surface
266834015759	TPR motif; other site
266834015760	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834015761	TPR motif; other site
266834015762	Tetratricopeptide repeat; Region: TPR_16; pfam13432
266834015763	binding surface
266834015764	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
266834015765	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
266834015766	DDE superfamily endonuclease; Region: DDE_3; pfam13358
266834015767	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
266834015768	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
266834015769	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
266834015770	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834015771	Homeodomain-like domain; Region: HTH_32; pfam13565
266834015772	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
266834015773	DAK2 domain; Region: Dak2; cl03685
266834015774	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
266834015775	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834015776	DNA binding residues [nucleotide binding]
266834015777	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
266834015778	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
266834015779	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
266834015780	DAK2 domain; Region: Dak2; pfam02734
266834015781	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
266834015782	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
266834015783	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834015784	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834015785	TM-ABC transporter signature motif; other site
266834015786	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
266834015787	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
266834015788	ligand binding site [chemical binding]; other site
266834015789	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834015790	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834015791	Walker A/P-loop; other site
266834015792	ATP binding site [chemical binding]; other site
266834015793	Q-loop/lid; other site
266834015794	ABC transporter signature motif; other site
266834015795	Walker B; other site
266834015796	D-loop; other site
266834015797	H-loop/switch region; other site
266834015798	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834015799	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834015800	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834015801	TM-ABC transporter signature motif; other site
266834015802	Predicted flavoproteins [General function prediction only]; Region: COG2081
266834015803	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834015804	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
266834015805	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
266834015806	DctM-like transporters; Region: DctM; pfam06808
266834015807	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
266834015808	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
266834015809	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834015810	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834015811	DNA-binding site [nucleotide binding]; DNA binding site
266834015812	FCD domain; Region: FCD; pfam07729
266834015813	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834015814	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834015815	DNA binding site [nucleotide binding]
266834015816	domain linker motif; other site
266834015817	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
266834015818	ligand binding site [chemical binding]; other site
266834015819	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834015820	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
266834015821	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834015822	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015823	dimer interface [polypeptide binding]; other site
266834015824	conserved gate region; other site
266834015825	putative PBP binding loops; other site
266834015826	ABC-ATPase subunit interface; other site
266834015827	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834015828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015829	dimer interface [polypeptide binding]; other site
266834015830	conserved gate region; other site
266834015831	putative PBP binding loops; other site
266834015832	ABC-ATPase subunit interface; other site
266834015833	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834015834	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834015835	Walker A/P-loop; other site
266834015836	ATP binding site [chemical binding]; other site
266834015837	Q-loop/lid; other site
266834015838	ABC transporter signature motif; other site
266834015839	Walker B; other site
266834015840	D-loop; other site
266834015841	H-loop/switch region; other site
266834015842	TOBE domain; Region: TOBE_2; pfam08402
266834015843	Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813
266834015844	conserved cys residue [active]
266834015845	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834015846	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834015847	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
266834015848	SPW repeat; Region: SPW; pfam03779
266834015849	SPW repeat; Region: SPW; pfam03779
266834015850	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
266834015851	Sulfatase; Region: Sulfatase; cl17466
266834015852	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
266834015853	Uncharacterized conserved protein [Function unknown]; Region: COG1262
266834015854	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
266834015855	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
266834015856	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834015857	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834015858	Major Facilitator Superfamily; Region: MFS_1; pfam07690
266834015859	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834015860	putative substrate translocation pore; other site
266834015861	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
266834015862	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
266834015863	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834015864	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834015865	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
266834015866	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834015867	catalytic loop [active]
266834015868	iron binding site [ion binding]; other site
266834015869	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
266834015870	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
266834015871	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
266834015872	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834015873	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
266834015874	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
266834015875	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834015876	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834015877	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834015878	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834015879	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
266834015880	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
266834015881	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
266834015882	ligand binding site [chemical binding]; other site
266834015883	dimerization interface [polypeptide binding]; other site
266834015884	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5618
266834015885	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834015886	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834015887	Walker A/P-loop; other site
266834015888	ATP binding site [chemical binding]; other site
266834015889	Q-loop/lid; other site
266834015890	ABC transporter signature motif; other site
266834015891	Walker B; other site
266834015892	D-loop; other site
266834015893	H-loop/switch region; other site
266834015894	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834015895	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834015896	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834015897	TM-ABC transporter signature motif; other site
266834015898	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834015899	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834015900	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
266834015901	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
266834015902	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
266834015903	dimerization interface [polypeptide binding]; other site
266834015904	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
266834015905	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834015906	dimer interface [polypeptide binding]; other site
266834015907	phosphorylation site [posttranslational modification]
266834015908	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834015909	ATP binding site [chemical binding]; other site
266834015910	Mg2+ binding site [ion binding]; other site
266834015911	G-X-G motif; other site
266834015912	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834015913	Response regulator receiver domain; Region: Response_reg; pfam00072
266834015914	active site
266834015915	phosphorylation site [posttranslational modification]
266834015916	intermolecular recognition site; other site
266834015917	dimerization interface [polypeptide binding]; other site
266834015918	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
266834015919	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834015920	active site
266834015921	phosphorylation site [posttranslational modification]
266834015922	intermolecular recognition site; other site
266834015923	Response regulator receiver domain; Region: Response_reg; pfam00072
266834015924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834015925	active site
266834015926	phosphorylation site [posttranslational modification]
266834015927	intermolecular recognition site; other site
266834015928	dimerization interface [polypeptide binding]; other site
266834015929	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834015930	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834015931	phosphorylation site [posttranslational modification]
266834015932	dimer interface [polypeptide binding]; other site
266834015933	Response regulator receiver domain; Region: Response_reg; pfam00072
266834015934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834015935	active site
266834015936	phosphorylation site [posttranslational modification]
266834015937	intermolecular recognition site; other site
266834015938	dimerization interface [polypeptide binding]; other site
266834015939	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
266834015940	cyclase homology domain; Region: CHD; cd07302
266834015941	nucleotidyl binding site; other site
266834015942	metal binding site [ion binding]; metal-binding site
266834015943	dimer interface [polypeptide binding]; other site
266834015944	Predicted periplasmic protein [Function unknown]; Region: COG3904
266834015945	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
266834015946	Ion channel; Region: Ion_trans_2; pfam07885
266834015947	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
266834015948	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
266834015949	active site
266834015950	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
266834015951	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834015952	Walker A/P-loop; other site
266834015953	ATP binding site [chemical binding]; other site
266834015954	Q-loop/lid; other site
266834015955	ABC transporter signature motif; other site
266834015956	Walker B; other site
266834015957	D-loop; other site
266834015958	H-loop/switch region; other site
266834015959	TOBE domain; Region: TOBE_2; pfam08402
266834015960	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
266834015961	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015962	dimer interface [polypeptide binding]; other site
266834015963	conserved gate region; other site
266834015964	putative PBP binding loops; other site
266834015965	ABC-ATPase subunit interface; other site
266834015966	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834015967	dimer interface [polypeptide binding]; other site
266834015968	conserved gate region; other site
266834015969	putative PBP binding loops; other site
266834015970	ABC-ATPase subunit interface; other site
266834015971	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
266834015972	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
266834015973	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834015974	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834015975	DNA binding site [nucleotide binding]
266834015976	domain linker motif; other site
266834015977	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
266834015978	putative dimerization interface [polypeptide binding]; other site
266834015979	putative ligand binding site [chemical binding]; other site
266834015980	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834015981	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834015982	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
266834015983	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834015984	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
266834015985	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
266834015986	FtsX-like permease family; Region: FtsX; pfam02687
266834015987	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
266834015988	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
266834015989	Walker A/P-loop; other site
266834015990	ATP binding site [chemical binding]; other site
266834015991	Q-loop/lid; other site
266834015992	ABC transporter signature motif; other site
266834015993	Walker B; other site
266834015994	D-loop; other site
266834015995	H-loop/switch region; other site
266834015996	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
266834015997	DctM-like transporters; Region: DctM; pfam06808
266834015998	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
266834015999	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
266834016000	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
266834016001	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
266834016002	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834016003	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834016004	DNA-binding site [nucleotide binding]; DNA binding site
266834016005	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
266834016006	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
266834016007	homotrimer interaction site [polypeptide binding]; other site
266834016008	putative active site [active]
266834016009	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
266834016010	homotrimer interaction site [polypeptide binding]; other site
266834016011	putative active site [active]
266834016012	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
266834016013	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
266834016014	tetramerization interface [polypeptide binding]; other site
266834016015	NAD(P) binding site [chemical binding]; other site
266834016016	catalytic residues [active]
266834016017	aminotransferase; Provisional; Region: PRK06105
266834016018	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834016019	inhibitor-cofactor binding pocket; inhibition site
266834016020	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834016021	catalytic residue [active]
266834016022	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
266834016023	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
266834016024	Walker A/P-loop; other site
266834016025	ATP binding site [chemical binding]; other site
266834016026	Q-loop/lid; other site
266834016027	ABC transporter signature motif; other site
266834016028	Walker B; other site
266834016029	D-loop; other site
266834016030	H-loop/switch region; other site
266834016031	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834016032	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834016033	dimer interface [polypeptide binding]; other site
266834016034	conserved gate region; other site
266834016035	putative PBP binding loops; other site
266834016036	ABC-ATPase subunit interface; other site
266834016037	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
266834016038	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
266834016039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834016040	dimer interface [polypeptide binding]; other site
266834016041	putative PBP binding loops; other site
266834016042	ABC-ATPase subunit interface; other site
266834016043	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
266834016044	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
266834016045	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
266834016046	active site
266834016047	Transcriptional regulator [Transcription]; Region: IclR; COG1414
266834016048	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
266834016049	Bacterial transcriptional regulator; Region: IclR; pfam01614
266834016050	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
266834016051	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
266834016052	NAD(P) binding site [chemical binding]; other site
266834016053	GAF domain; Region: GAF; pfam01590
266834016054	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
266834016055	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
266834016056	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834016057	metal binding site [ion binding]; metal-binding site
266834016058	active site
266834016059	I-site; other site
266834016060	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
266834016061	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834016062	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
266834016063	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
266834016064	DXD motif; other site
266834016065	transcriptional regulator NanR; Provisional; Region: PRK03837
266834016066	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834016067	DNA-binding site [nucleotide binding]; DNA binding site
266834016068	Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969
266834016069	FCD domain; Region: FCD; pfam07729
266834016070	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
266834016071	Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207
266834016072	dimer interface [polypeptide binding]; other site
266834016073	active site
266834016074	catalytic residue [active]
266834016075	metal binding site [ion binding]; metal-binding site
266834016076	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
266834016077	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
266834016078	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
266834016079	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834016080	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
266834016081	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
266834016082	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
266834016083	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834016084	catalytic loop [active]
266834016085	iron binding site [ion binding]; other site
266834016086	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
266834016087	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
266834016088	putative active site [active]
266834016089	putative metal binding site [ion binding]; other site
266834016090	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
266834016091	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
266834016092	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
266834016093	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
266834016094	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
266834016095	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834016096	catalytic loop [active]
266834016097	iron binding site [ion binding]; other site
266834016098	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
266834016099	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
266834016100	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834016101	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
266834016102	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834016103	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834016104	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
266834016105	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834016106	DNA binding residues [nucleotide binding]
266834016107	dimerization interface [polypeptide binding]; other site
266834016108	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
266834016109	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
266834016110	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
266834016111	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
266834016112	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
266834016113	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
266834016114	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
266834016115	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
266834016116	classical (c) SDRs; Region: SDR_c; cd05233
266834016117	NAD(P) binding site [chemical binding]; other site
266834016118	active site
266834016119	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
266834016120	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
266834016121	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
266834016122	Predicted integral membrane protein [Function unknown]; Region: COG5528
266834016123	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
266834016124	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
266834016125	putative NAD(P) binding site [chemical binding]; other site
266834016126	active site
266834016127	DoxX-like family; Region: DoxX_3; pfam13781
266834016128	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
266834016129	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834016130	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
266834016131	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834016132	dimer interface [polypeptide binding]; other site
266834016133	conserved gate region; other site
266834016134	putative PBP binding loops; other site
266834016135	ABC-ATPase subunit interface; other site
266834016136	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834016137	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834016138	dimer interface [polypeptide binding]; other site
266834016139	conserved gate region; other site
266834016140	ABC-ATPase subunit interface; other site
266834016141	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834016142	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834016143	Walker A/P-loop; other site
266834016144	ATP binding site [chemical binding]; other site
266834016145	Q-loop/lid; other site
266834016146	ABC transporter signature motif; other site
266834016147	Walker B; other site
266834016148	D-loop; other site
266834016149	H-loop/switch region; other site
266834016150	TOBE domain; Region: TOBE_2; pfam08402
266834016151	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
266834016152	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
266834016153	putative C-terminal domain interface [polypeptide binding]; other site
266834016154	putative GSH binding site (G-site) [chemical binding]; other site
266834016155	putative dimer interface [polypeptide binding]; other site
266834016156	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
266834016157	dimer interface [polypeptide binding]; other site
266834016158	N-terminal domain interface [polypeptide binding]; other site
266834016159	putative substrate binding pocket (H-site) [chemical binding]; other site
266834016160	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
266834016161	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
266834016162	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
266834016163	Transposase [DNA replication, recombination, and repair]; Region: COG5433
266834016164	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
266834016165	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
266834016166	putative NAD(P) binding site [chemical binding]; other site
266834016167	hypothetical protein; Provisional; Region: PRK07482
266834016168	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834016169	inhibitor-cofactor binding pocket; inhibition site
266834016170	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834016171	catalytic residue [active]
266834016172	succinic semialdehyde dehydrogenase; Region: PLN02278
266834016173	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
266834016174	tetramerization interface [polypeptide binding]; other site
266834016175	NAD(P) binding site [chemical binding]; other site
266834016176	catalytic residues [active]
266834016177	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834016178	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834016179	putative DNA binding site [nucleotide binding]; other site
266834016180	putative Zn2+ binding site [ion binding]; other site
266834016181	AsnC family; Region: AsnC_trans_reg; pfam01037
266834016182	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
266834016183	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834016184	DNA-binding site [nucleotide binding]; DNA binding site
266834016185	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834016186	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834016187	homodimer interface [polypeptide binding]; other site
266834016188	catalytic residue [active]
266834016189	ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005
266834016190	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
266834016191	Walker A/P-loop; other site
266834016192	ATP binding site [chemical binding]; other site
266834016193	Q-loop/lid; other site
266834016194	ABC transporter signature motif; other site
266834016195	Walker B; other site
266834016196	D-loop; other site
266834016197	H-loop/switch region; other site
266834016198	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
266834016199	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834016200	substrate binding pocket [chemical binding]; other site
266834016201	membrane-bound complex binding site; other site
266834016202	hinge residues; other site
266834016203	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834016204	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834016205	dimer interface [polypeptide binding]; other site
266834016206	conserved gate region; other site
266834016207	putative PBP binding loops; other site
266834016208	ABC-ATPase subunit interface; other site
266834016209	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834016210	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834016211	dimer interface [polypeptide binding]; other site
266834016212	conserved gate region; other site
266834016213	putative PBP binding loops; other site
266834016214	ABC-ATPase subunit interface; other site
266834016215	ectoine utilization protein EutA; Region: ectoine_eutA; TIGR02990
266834016216	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
266834016217	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
266834016218	tetramer interface [polypeptide binding]; other site
266834016219	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834016220	catalytic residue [active]
266834016221	ectoine utilization protein EutC; Validated; Region: PRK08291
266834016222	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
266834016223	ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993
266834016224	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
266834016225	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
266834016226	active site
266834016227	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
266834016228	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
266834016229	putative active site [active]
266834016230	Zn binding site [ion binding]; other site
266834016231	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
266834016232	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834016233	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834016234	DNA-binding site [nucleotide binding]; DNA binding site
266834016235	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
266834016236	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
266834016237	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
266834016238	DctM-like transporters; Region: DctM; pfam06808
266834016239	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
266834016240	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
266834016241	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
266834016242	putative NAD(P) binding site [chemical binding]; other site
266834016243	catalytic Zn binding site [ion binding]; other site
266834016244	mannonate dehydratase; Provisional; Region: PRK03906
266834016245	mannonate dehydratase; Region: uxuA; TIGR00695
266834016246	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
266834016247	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834016248	metal binding site [ion binding]; metal-binding site
266834016249	active site
266834016250	I-site; other site
266834016251	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834016252	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
266834016253	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834016254	S-adenosylmethionine binding site [chemical binding]; other site
266834016255	Cache domain; Region: Cache_1; pfam02743
266834016256	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
266834016257	dimerization interface [polypeptide binding]; other site
266834016258	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
266834016259	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
266834016260	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
266834016261	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
266834016262	anti sigma factor interaction site; other site
266834016263	regulatory phosphorylation site [posttranslational modification]; other site
266834016264	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
266834016265	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
266834016266	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834016267	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834016268	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
266834016269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834016270	NAD(P) binding site [chemical binding]; other site
266834016271	active site
266834016272	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834016273	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834016274	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834016275	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
266834016276	NAD binding site [chemical binding]; other site
266834016277	putative substrate binding site 2 [chemical binding]; other site
266834016278	putative substrate binding site 1 [chemical binding]; other site
266834016279	active site
266834016280	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
266834016281	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
266834016282	NAD binding site [chemical binding]; other site
266834016283	homodimer interface [polypeptide binding]; other site
266834016284	active site
266834016285	substrate binding site [chemical binding]; other site
266834016286	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
266834016287	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
266834016288	active site
266834016289	Cellulose synthase-like protein; Region: PLN02893
266834016290	Protein of unknown function (DUF995); Region: DUF995; pfam06191
266834016291	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
266834016292	Protein of unknown function (DUF995); Region: DUF995; pfam06191
266834016293	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
266834016294	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
266834016295	nucleotide binding site [chemical binding]; other site
266834016296	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
266834016297	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
266834016298	putative oligomer interface [polypeptide binding]; other site
266834016299	putative active site [active]
266834016300	metal binding site [ion binding]; metal-binding site
266834016301	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
266834016302	Histidine kinase; Region: HisKA_3; pfam07730
266834016303	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
266834016304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834016305	active site
266834016306	phosphorylation site [posttranslational modification]
266834016307	intermolecular recognition site; other site
266834016308	dimerization interface [polypeptide binding]; other site
266834016309	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834016310	DNA binding residues [nucleotide binding]
266834016311	dimerization interface [polypeptide binding]; other site
266834016312	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
266834016313	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
266834016314	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
266834016315	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
266834016316	dimer interface [polypeptide binding]; other site
266834016317	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834016318	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
266834016319	peptide binding site [polypeptide binding]; other site
266834016320	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834016321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834016322	dimer interface [polypeptide binding]; other site
266834016323	conserved gate region; other site
266834016324	putative PBP binding loops; other site
266834016325	ABC-ATPase subunit interface; other site
266834016326	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
266834016327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834016328	dimer interface [polypeptide binding]; other site
266834016329	conserved gate region; other site
266834016330	putative PBP binding loops; other site
266834016331	ABC-ATPase subunit interface; other site
266834016332	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
266834016333	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834016334	Walker A/P-loop; other site
266834016335	ATP binding site [chemical binding]; other site
266834016336	Q-loop/lid; other site
266834016337	ABC transporter signature motif; other site
266834016338	Walker B; other site
266834016339	D-loop; other site
266834016340	H-loop/switch region; other site
266834016341	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
266834016342	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
266834016343	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834016344	Walker A/P-loop; other site
266834016345	ATP binding site [chemical binding]; other site
266834016346	Q-loop/lid; other site
266834016347	ABC transporter signature motif; other site
266834016348	Walker B; other site
266834016349	D-loop; other site
266834016350	H-loop/switch region; other site
266834016351	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834016352	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834016353	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834016354	DNA-binding site [nucleotide binding]; DNA binding site
266834016355	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
266834016356	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
266834016357	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
266834016358	active site
266834016359	dimer interface [polypeptide binding]; other site
266834016360	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
266834016361	Ligand Binding Site [chemical binding]; other site
266834016362	Molecular Tunnel; other site
266834016363	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
266834016364	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834016365	Coenzyme A binding pocket [chemical binding]; other site
266834016366	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
266834016367	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834016368	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
266834016369	dimerization interface [polypeptide binding]; other site
266834016370	ligand binding site [chemical binding]; other site
266834016371	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
266834016372	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
266834016373	ligand binding site [chemical binding]; other site
266834016374	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834016375	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834016376	Walker A/P-loop; other site
266834016377	ATP binding site [chemical binding]; other site
266834016378	Q-loop/lid; other site
266834016379	ABC transporter signature motif; other site
266834016380	Walker B; other site
266834016381	D-loop; other site
266834016382	H-loop/switch region; other site
266834016383	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834016384	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834016385	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834016386	TM-ABC transporter signature motif; other site
266834016387	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834016388	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834016389	TM-ABC transporter signature motif; other site
266834016390	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
266834016391	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
266834016392	Metal-binding active site; metal-binding site
266834016393	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
266834016394	Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772
266834016395	N- and C-terminal domain interface [polypeptide binding]; other site
266834016396	putative active site [active]
266834016397	putative MgATP binding site [chemical binding]; other site
266834016398	putative catalytic site [active]
266834016399	metal binding site [ion binding]; metal-binding site
266834016400	putative carbohydrate binding site [chemical binding]; other site
266834016401	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
266834016402	intersubunit interface [polypeptide binding]; other site
266834016403	active site
266834016404	Zn2+ binding site [ion binding]; other site
266834016405	Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828
266834016406	Isochorismatase family; Region: Isochorismatase; pfam00857
266834016407	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
266834016408	catalytic triad [active]
266834016409	conserved cis-peptide bond; other site
266834016410	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
266834016411	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
266834016412	NADP binding site [chemical binding]; other site
266834016413	active site
266834016414	steroid binding site; other site
266834016415	short chain dehydrogenase; Provisional; Region: PRK12937
266834016416	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
266834016417	NADP binding site [chemical binding]; other site
266834016418	homodimer interface [polypeptide binding]; other site
266834016419	active site
266834016420	substrate binding site [chemical binding]; other site
266834016421	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834016422	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834016423	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
266834016424	putative effector binding pocket; other site
266834016425	putative dimerization interface [polypeptide binding]; other site
266834016426	TPR repeat; Region: TPR_11; pfam13414
266834016427	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
266834016428	TPR motif; other site
266834016429	binding surface
266834016430	choline dehydrogenase; Validated; Region: PRK02106
266834016431	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
266834016432	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
266834016433	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
266834016434	putative N- and C-terminal domain interface [polypeptide binding]; other site
266834016435	putative active site [active]
266834016436	MgATP binding site [chemical binding]; other site
266834016437	catalytic site [active]
266834016438	metal binding site [ion binding]; metal-binding site
266834016439	putative xylulose binding site [chemical binding]; other site
266834016440	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
266834016441	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
266834016442	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
266834016443	putative active site; other site
266834016444	catalytic residue [active]
266834016445	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
266834016446	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
266834016447	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834016448	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834016449	active site
266834016450	catalytic tetrad [active]
266834016451	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
266834016452	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834016453	DNA binding residues [nucleotide binding]
266834016454	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
266834016455	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834016456	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834016457	TM-ABC transporter signature motif; other site
266834016458	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834016459	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834016460	Walker A/P-loop; other site
266834016461	ATP binding site [chemical binding]; other site
266834016462	Q-loop/lid; other site
266834016463	ABC transporter signature motif; other site
266834016464	Walker B; other site
266834016465	D-loop; other site
266834016466	H-loop/switch region; other site
266834016467	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834016468	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834016469	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
266834016470	ligand binding site [chemical binding]; other site
266834016471	Phosphotransferase enzyme family; Region: APH; pfam01636
266834016472	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
266834016473	active site
266834016474	ATP binding site [chemical binding]; other site
266834016475	substrate binding site [chemical binding]; other site
266834016476	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834016477	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834016478	TM-ABC transporter signature motif; other site
266834016479	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
266834016480	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834016481	Walker A/P-loop; other site
266834016482	ATP binding site [chemical binding]; other site
266834016483	Q-loop/lid; other site
266834016484	ABC transporter signature motif; other site
266834016485	Walker B; other site
266834016486	D-loop; other site
266834016487	H-loop/switch region; other site
266834016488	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834016489	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
266834016490	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
266834016491	ligand binding site [chemical binding]; other site
266834016492	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834016493	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834016494	DNA-binding site [nucleotide binding]; DNA binding site
266834016495	FCD domain; Region: FCD; pfam07729
266834016496	galactonate dehydratase; Provisional; Region: PRK14017
266834016497	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
266834016498	putative active site pocket [active]
266834016499	putative metal binding site [ion binding]; other site
266834016500	short chain dehydrogenase; Provisional; Region: PRK07063
266834016501	classical (c) SDRs; Region: SDR_c; cd05233
266834016502	NAD(P) binding site [chemical binding]; other site
266834016503	active site
266834016504	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834016505	Coenzyme A binding pocket [chemical binding]; other site
266834016506	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
266834016507	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
266834016508	putative active site [active]
266834016509	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
266834016510	CheB methylesterase; Region: CheB_methylest; pfam01339
266834016511	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
266834016512	CheB methylesterase; Region: CheB_methylest; pfam01339
266834016513	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
266834016514	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
266834016515	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
266834016516	PAS domain; Region: PAS_10; pfam13596
266834016517	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834016518	putative active site [active]
266834016519	heme pocket [chemical binding]; other site
266834016520	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834016521	PAS domain; Region: PAS_9; pfam13426
266834016522	putative active site [active]
266834016523	heme pocket [chemical binding]; other site
266834016524	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
266834016525	HWE histidine kinase; Region: HWE_HK; pfam07536
266834016526	Predicted chitinase [General function prediction only]; Region: COG3179
266834016527	catalytic residue [active]
266834016528	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834016529	Protein of unknown function (DUF1515); Region: DUF1515; pfam07439
266834016530	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
266834016531	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
266834016532	PRC-barrel domain; Region: PRC; pfam05239
266834016533	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
266834016534	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834016535	metal binding site [ion binding]; metal-binding site
266834016536	active site
266834016537	I-site; other site
266834016538	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834016539	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834016540	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
266834016541	hypothetical protein; Provisional; Region: PRK05409
266834016542	Predicted integral membrane protein [Function unknown]; Region: COG5572
266834016543	RNA polymerase sigma factor; Provisional; Region: PRK12512
266834016544	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
266834016545	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834016546	DNA binding residues [nucleotide binding]
266834016547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944
266834016548	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
266834016549	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
266834016550	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
266834016551	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
266834016552	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
266834016553	putative ligand binding site [chemical binding]; other site
266834016554	putative NAD binding site [chemical binding]; other site
266834016555	catalytic site [active]
266834016556	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289
266834016557	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834016558	DNA binding site [nucleotide binding]
266834016559	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834016560	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
266834016561	ligand binding site [chemical binding]; other site
266834016562	dimerization interface [polypeptide binding]; other site
266834016563	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834016564	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834016565	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834016566	cyclase homology domain; Region: CHD; cd07302
266834016567	nucleotidyl binding site; other site
266834016568	metal binding site [ion binding]; metal-binding site
266834016569	dimer interface [polypeptide binding]; other site
266834016570	Predicted integral membrane protein [Function unknown]; Region: COG5616
266834016571	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834016572	TPR motif; other site
266834016573	TPR repeat; Region: TPR_11; pfam13414
266834016574	binding surface
266834016575	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834016576	binding surface
266834016577	TPR motif; other site
266834016578	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
266834016579	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834016580	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
266834016581	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
266834016582	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
266834016583	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834016584	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
266834016585	Transposase; Region: HTH_Tnp_1; pfam01527
266834016586	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834016587	Protein of unknown function (DUF982); Region: DUF982; pfam06169
266834016588	Transcriptional activator, adenine-specific DNA methyltransferase [Signal transduction mechanisms / Transcription]; Region: IME4; COG4725
266834016589	Protein of unknown function (DUF982); Region: DUF982; pfam06169
266834016590	Protein of unknown function (DUF982); Region: DUF982; pfam06169
266834016591	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
266834016592	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
266834016593	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4333
266834016594	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
266834016595	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
266834016596	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
266834016597	dimer interface [polypeptide binding]; other site
266834016598	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
266834016599	metal-binding site [ion binding]
266834016600	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
266834016601	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
266834016602	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
266834016603	Glycosyltransferase family 92; Region: Glyco_transf_92; pfam01697
266834016604	active site
266834016605	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
266834016606	active site
266834016607	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
266834016608	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
266834016609	KpsF/GutQ family protein; Region: kpsF; TIGR00393
266834016610	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
266834016611	putative active site [active]
266834016612	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
266834016613	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
266834016614	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
266834016615	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
266834016616	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
266834016617	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834016618	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
266834016619	Walker A/P-loop; other site
266834016620	ATP binding site [chemical binding]; other site
266834016621	Q-loop/lid; other site
266834016622	ABC transporter signature motif; other site
266834016623	Walker B; other site
266834016624	D-loop; other site
266834016625	H-loop/switch region; other site
266834016626	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
266834016627	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
266834016628	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
266834016629	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
266834016630	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
266834016631	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834016632	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834016633	DNA binding site [nucleotide binding]
266834016634	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
266834016635	putative ligand binding site [chemical binding]; other site
266834016636	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
266834016637	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
266834016638	putative di-iron ligands [ion binding]; other site
266834016639	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
266834016640	[2Fe-2S] cluster binding site [ion binding]; other site
266834016641	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
266834016642	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834016643	Ketopantoate hydroxymethyltransferase [Coenzyme metabolism]; Region: PanB; COG0413
266834016644	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
266834016645	ABC-2 type transporter; Region: ABC2_membrane; cl17235
266834016646	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
266834016647	Predicted glycosyltransferase involved in capsule biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG4092
266834016648	N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476
266834016649	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
266834016650	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
266834016651	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
266834016652	trimer interface [polypeptide binding]; other site
266834016653	active site
266834016654	substrate binding site [chemical binding]; other site
266834016655	CoA binding site [chemical binding]; other site
266834016656	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834016657	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834016658	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834016659	DDE domain; Region: DDE_Tnp_IS240; pfam13610
266834016660	Integrase core domain; Region: rve; pfam00665
266834016661	Integrase core domain; Region: rve_2; pfam13333
266834016662	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
266834016663	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
266834016664	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
266834016665	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
266834016666	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
266834016667	KpsF/GutQ family protein; Region: kpsF; TIGR00393
266834016668	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
266834016669	putative active site [active]
266834016670	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
266834016671	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
266834016672	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
266834016673	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
266834016674	Walker A/P-loop; other site
266834016675	ATP binding site [chemical binding]; other site
266834016676	Q-loop/lid; other site
266834016677	ABC transporter signature motif; other site
266834016678	Walker B; other site
266834016679	D-loop; other site
266834016680	H-loop/switch region; other site
266834016681	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
266834016682	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
266834016683	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
266834016684	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
266834016685	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
266834016686	active site
266834016687	NTP binding site [chemical binding]; other site
266834016688	metal binding triad [ion binding]; metal-binding site
266834016689	antibiotic binding site [chemical binding]; other site
266834016690	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
266834016691	Uncharacterized conserved protein [Function unknown]; Region: COG3347
266834016692	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
266834016693	Uncharacterized conserved protein [Function unknown]; Region: COG5556
266834016694	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
266834016695	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
266834016696	Acid Phosphatase; Region: Acid_PPase; cl17256
266834016697	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
266834016698	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
266834016699	dimer interface [polypeptide binding]; other site
266834016700	substrate binding site [chemical binding]; other site
266834016701	metal binding site [ion binding]; metal-binding site
266834016702	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563
266834016703	Uncharacterized conserved protein [Function unknown]; Region: COG3347
266834016704	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
266834016705	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
266834016706	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
266834016707	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834016708	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834016709	TM-ABC transporter signature motif; other site
266834016710	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834016711	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834016712	TM-ABC transporter signature motif; other site
266834016713	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
266834016714	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834016715	Walker A/P-loop; other site
266834016716	ATP binding site [chemical binding]; other site
266834016717	Q-loop/lid; other site
266834016718	ABC transporter signature motif; other site
266834016719	Walker B; other site
266834016720	D-loop; other site
266834016721	H-loop/switch region; other site
266834016722	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834016723	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
266834016724	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
266834016725	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
266834016726	L-fuculokinase; Provisional; Region: PRK10331
266834016727	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
266834016728	putative N- and C-terminal domain interface [polypeptide binding]; other site
266834016729	putative active site [active]
266834016730	putative MgATP binding site [chemical binding]; other site
266834016731	catalytic site [active]
266834016732	metal binding site [ion binding]; metal-binding site
266834016733	putative carbohydrate binding site [chemical binding]; other site
266834016734	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
266834016735	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
266834016736	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834016737	non-specific DNA binding site [nucleotide binding]; other site
266834016738	salt bridge; other site
266834016739	sequence-specific DNA binding site [nucleotide binding]; other site
266834016740	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834016741	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
266834016742	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834016743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834016744	dimer interface [polypeptide binding]; other site
266834016745	conserved gate region; other site
266834016746	putative PBP binding loops; other site
266834016747	ABC-ATPase subunit interface; other site
266834016748	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
266834016749	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834016750	dimer interface [polypeptide binding]; other site
266834016751	conserved gate region; other site
266834016752	putative PBP binding loops; other site
266834016753	ABC-ATPase subunit interface; other site
266834016754	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
266834016755	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834016756	Walker A/P-loop; other site
266834016757	ATP binding site [chemical binding]; other site
266834016758	Q-loop/lid; other site
266834016759	ABC transporter signature motif; other site
266834016760	Walker B; other site
266834016761	D-loop; other site
266834016762	H-loop/switch region; other site
266834016763	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834016764	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834016765	Walker A/P-loop; other site
266834016766	ATP binding site [chemical binding]; other site
266834016767	Q-loop/lid; other site
266834016768	ABC transporter signature motif; other site
266834016769	Walker B; other site
266834016770	D-loop; other site
266834016771	H-loop/switch region; other site
266834016772	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
266834016773	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
266834016774	putative active site [active]
266834016775	putative metal binding site [ion binding]; other site
266834016776	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
266834016777	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
266834016778	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
266834016779	metal binding site [ion binding]; metal-binding site
266834016780	dimer interface [polypeptide binding]; other site
266834016781	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
266834016782	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
266834016783	active site
266834016784	DNA binding site [nucleotide binding]
266834016785	DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776
266834016786	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
266834016787	DNA binding site [nucleotide binding]
266834016788	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
266834016789	nucleotide binding site [chemical binding]; other site
266834016790	Staphylococcal nuclease homologues; Region: SNc; smart00318
266834016791	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
266834016792	Catalytic site; other site
266834016793	GXWXG protein; Region: GXWXG; pfam14231
266834016794	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
266834016795	Winged helix-turn helix; Region: HTH_29; pfam13551
266834016796	Homeodomain-like domain; Region: HTH_32; pfam13565
266834016797	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
266834016798	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
266834016799	putative active site [active]
266834016800	putative NTP binding site [chemical binding]; other site
266834016801	putative nucleic acid binding site [nucleotide binding]; other site
266834016802	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
266834016803	DDE superfamily endonuclease; Region: DDE_3; pfam13358
266834016804	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
266834016805	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
266834016806	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
266834016807	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
266834016808	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
266834016809	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
266834016810	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
266834016811	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834016812	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834016813	NAD(P) binding site [chemical binding]; other site
266834016814	active site
266834016815	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834016816	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
266834016817	Methyltransferase domain; Region: Methyltransf_23; pfam13489
266834016818	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834016819	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
266834016820	Family description; Region: VCBS; pfam13517
266834016821	Family description; Region: VCBS; pfam13517
266834016822	Family description; Region: VCBS; pfam13517
266834016823	Family description; Region: VCBS; pfam13517
266834016824	Family description; Region: VCBS; pfam13517
266834016825	Family description; Region: VCBS; pfam13517
266834016826	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
266834016827	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
266834016828	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
266834016829	active site
266834016830	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
266834016831	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
266834016832	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
266834016833	extended (e) SDRs; Region: SDR_e; cd08946
266834016834	NAD(P) binding site [chemical binding]; other site
266834016835	active site
266834016836	substrate binding site [chemical binding]; other site
266834016837	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
266834016838	Methyltransferase domain; Region: Methyltransf_23; pfam13489
266834016839	Methyltransferase domain; Region: Methyltransf_12; pfam08242
266834016840	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
266834016841	Methyltransferase domain; Region: Methyltransf_23; pfam13489
266834016842	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834016843	S-adenosylmethionine binding site [chemical binding]; other site
266834016844	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
266834016845	Protein of unknown function (DUF707); Region: DUF707; pfam05212
266834016846	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
266834016847	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
266834016848	active site
266834016849	Methyltransferase domain; Region: Methyltransf_23; pfam13489
266834016850	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834016851	S-adenosylmethionine binding site [chemical binding]; other site
266834016852	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
266834016853	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
266834016854	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
266834016855	active site
266834016856	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
266834016857	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
266834016858	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
266834016859	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
266834016860	AAA domain; Region: AAA_31; pfam13614
266834016861	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
266834016862	Bacterial sugar transferase; Region: Bac_transf; pfam02397
266834016863	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
266834016864	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
266834016865	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
266834016866	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
266834016867	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834016868	putative ADP-binding pocket [chemical binding]; other site
266834016869	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
266834016870	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834016871	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834016872	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
266834016873	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
266834016874	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
266834016875	ligand binding site [chemical binding]; other site
266834016876	flexible hinge region; other site
266834016877	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
266834016878	putative switch regulator; other site
266834016879	non-specific DNA interactions [nucleotide binding]; other site
266834016880	DNA binding site [nucleotide binding]
266834016881	sequence specific DNA binding site [nucleotide binding]; other site
266834016882	putative cAMP binding site [chemical binding]; other site
266834016883	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
266834016884	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834016885	DNA binding residues [nucleotide binding]
266834016886	dimerization interface [polypeptide binding]; other site
266834016887	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
266834016888	active site
266834016889	substrate binding site [chemical binding]; other site
266834016890	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
266834016891	metal binding site [ion binding]; metal-binding site
266834016892	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
266834016893	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
266834016894	Substrate binding site; other site
266834016895	Cupin domain; Region: Cupin_2; cl17218
266834016896	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
266834016897	dimerization interface [polypeptide binding]; other site
266834016898	putative active cleft [active]
266834016899	Transposase; Region: HTH_Tnp_1; pfam01527
266834016900	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834016901	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834016902	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
266834016903	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
266834016904	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
266834016905	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
266834016906	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
266834016907	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
266834016908	cyclase homology domain; Region: CHD; cd07302
266834016909	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834016910	metal binding site [ion binding]; metal-binding site
266834016911	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
266834016912	MobA/MobL family; Region: MobA_MobL; pfam03389
266834016913	AAA domain; Region: AAA_30; pfam13604
266834016914	Family description; Region: UvrD_C_2; pfam13538
266834016915	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
266834016916	CoA-transferase family III; Region: CoA_transf_3; pfam02515
266834016917	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834016918	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
266834016919	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
266834016920	active site
266834016921	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834016922	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
266834016923	Coenzyme A binding pocket [chemical binding]; other site
266834016924	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
266834016925	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834016926	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834016927	dimerization interface [polypeptide binding]; other site
266834016928	argininosuccinate lyase; Provisional; Region: PRK00855
266834016929	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
266834016930	active sites [active]
266834016931	tetramer interface [polypeptide binding]; other site
266834016932	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
266834016933	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834016934	dimer interface [polypeptide binding]; other site
266834016935	conserved gate region; other site
266834016936	putative PBP binding loops; other site
266834016937	ABC-ATPase subunit interface; other site
266834016938	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
266834016939	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
266834016940	Walker A/P-loop; other site
266834016941	ATP binding site [chemical binding]; other site
266834016942	Q-loop/lid; other site
266834016943	ABC transporter signature motif; other site
266834016944	Walker B; other site
266834016945	D-loop; other site
266834016946	H-loop/switch region; other site
266834016947	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
266834016948	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834016949	substrate binding pocket [chemical binding]; other site
266834016950	membrane-bound complex binding site; other site
266834016951	hinge residues; other site
266834016952	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
266834016953	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
266834016954	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
266834016955	active site
266834016956	catalytic site [active]
266834016957	Zn binding site [ion binding]; other site
266834016958	tetramer interface [polypeptide binding]; other site
266834016959	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
266834016960	Amidohydrolase; Region: Amidohydro_2; pfam04909
266834016961	Transcriptional regulator [Transcription]; Region: IclR; COG1414
266834016962	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834016963	putative DNA binding site [nucleotide binding]; other site
266834016964	putative Zn2+ binding site [ion binding]; other site
266834016965	Bacterial transcriptional regulator; Region: IclR; pfam01614
266834016966	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834016967	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834016968	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834016969	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834016970	dimer interface [polypeptide binding]; other site
266834016971	conserved gate region; other site
266834016972	putative PBP binding loops; other site
266834016973	ABC-ATPase subunit interface; other site
266834016974	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834016975	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834016976	dimer interface [polypeptide binding]; other site
266834016977	conserved gate region; other site
266834016978	putative PBP binding loops; other site
266834016979	ABC-ATPase subunit interface; other site
266834016980	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834016981	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834016982	Walker A/P-loop; other site
266834016983	ATP binding site [chemical binding]; other site
266834016984	Q-loop/lid; other site
266834016985	ABC transporter signature motif; other site
266834016986	Walker B; other site
266834016987	D-loop; other site
266834016988	H-loop/switch region; other site
266834016989	TOBE domain; Region: TOBE_2; pfam08402
266834016990	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
266834016991	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
266834016992	active site pocket [active]
266834016993	Uncharacterized conserved protein [Function unknown]; Region: COG3254
266834016994	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834016995	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834016996	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
266834016997	active site 2 [active]
266834016998	active site 1 [active]
266834016999	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834017000	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
266834017001	NAD binding site [chemical binding]; other site
266834017002	homotetramer interface [polypeptide binding]; other site
266834017003	homodimer interface [polypeptide binding]; other site
266834017004	active site
266834017005	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
266834017006	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
266834017007	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
266834017008	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
266834017009	putative active site pocket [active]
266834017010	metal binding site [ion binding]; metal-binding site
266834017011	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
266834017012	NMT1-like family; Region: NMT1_2; pfam13379
266834017013	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
266834017014	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
266834017015	active site
266834017016	phosphorylation site [posttranslational modification]
266834017017	intermolecular recognition site; other site
266834017018	ANTAR domain; Region: ANTAR; pfam03861
266834017019	Uncharacterized conserved protein [Function unknown]; Region: COG3482
266834017020	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
266834017021	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834017022	non-specific DNA binding site [nucleotide binding]; other site
266834017023	salt bridge; other site
266834017024	sequence-specific DNA binding site [nucleotide binding]; other site
266834017025	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
266834017026	Shikimate kinase; Region: SKI; pfam01202
266834017027	isovaleryl-CoA dehydrogenase; Region: PLN02519
266834017028	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
266834017029	substrate binding site [chemical binding]; other site
266834017030	FAD binding site [chemical binding]; other site
266834017031	catalytic base [active]
266834017032	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
266834017033	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
266834017034	homotrimer interaction site [polypeptide binding]; other site
266834017035	putative active site [active]
266834017036	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
266834017037	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
266834017038	ATP-grasp domain; Region: ATP-grasp_4; cl17255
266834017039	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
266834017040	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
266834017041	carboxyltransferase (CT) interaction site; other site
266834017042	biotinylation site [posttranslational modification]; other site
266834017043	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
266834017044	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
266834017045	active site
266834017046	catalytic residues [active]
266834017047	metal binding site [ion binding]; metal-binding site
266834017048	enoyl-CoA hydratase; Provisional; Region: PRK07468
266834017049	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
266834017050	substrate binding site [chemical binding]; other site
266834017051	oxyanion hole (OAH) forming residues; other site
266834017052	trimer interface [polypeptide binding]; other site
266834017053	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
266834017054	Uncharacterized conserved protein [Function unknown]; Region: COG5654
266834017055	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
266834017056	FAD binding domain; Region: FAD_binding_4; pfam01565
266834017057	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
266834017058	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
266834017059	Walker A/P-loop; other site
266834017060	ATP binding site [chemical binding]; other site
266834017061	Q-loop/lid; other site
266834017062	ABC transporter signature motif; other site
266834017063	Walker B; other site
266834017064	D-loop; other site
266834017065	H-loop/switch region; other site
266834017066	TOBE-like domain; Region: TOBE_3; pfam12857
266834017067	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017068	dimer interface [polypeptide binding]; other site
266834017069	conserved gate region; other site
266834017070	putative PBP binding loops; other site
266834017071	ABC-ATPase subunit interface; other site
266834017072	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
266834017073	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017074	dimer interface [polypeptide binding]; other site
266834017075	conserved gate region; other site
266834017076	putative PBP binding loops; other site
266834017077	ABC-ATPase subunit interface; other site
266834017078	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
266834017079	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
266834017080	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
266834017081	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
266834017082	dimer interface [polypeptide binding]; other site
266834017083	active site
266834017084	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
266834017085	substrate binding site [chemical binding]; other site
266834017086	catalytic residue [active]
266834017087	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
266834017088	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834017089	substrate binding pocket [chemical binding]; other site
266834017090	membrane-bound complex binding site; other site
266834017091	hinge residues; other site
266834017092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017093	dimer interface [polypeptide binding]; other site
266834017094	conserved gate region; other site
266834017095	putative PBP binding loops; other site
266834017096	ABC-ATPase subunit interface; other site
266834017097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017098	dimer interface [polypeptide binding]; other site
266834017099	conserved gate region; other site
266834017100	putative PBP binding loops; other site
266834017101	ABC-ATPase subunit interface; other site
266834017102	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
266834017103	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834017104	Walker A/P-loop; other site
266834017105	ATP binding site [chemical binding]; other site
266834017106	Q-loop/lid; other site
266834017107	ABC transporter signature motif; other site
266834017108	Walker B; other site
266834017109	D-loop; other site
266834017110	H-loop/switch region; other site
266834017111	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
266834017112	homotrimer interaction site [polypeptide binding]; other site
266834017113	putative active site [active]
266834017114	Transcriptional regulator [Transcription]; Region: IclR; COG1414
266834017115	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
266834017116	Bacterial transcriptional regulator; Region: IclR; pfam01614
266834017117	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834017118	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834017119	Walker A/P-loop; other site
266834017120	ATP binding site [chemical binding]; other site
266834017121	Q-loop/lid; other site
266834017122	ABC transporter signature motif; other site
266834017123	Walker B; other site
266834017124	D-loop; other site
266834017125	H-loop/switch region; other site
266834017126	TOBE domain; Region: TOBE_2; pfam08402
266834017127	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
266834017128	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
266834017129	substrate binding site [chemical binding]; other site
266834017130	ATP binding site [chemical binding]; other site
266834017131	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
266834017132	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
266834017133	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
266834017134	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834017135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017136	dimer interface [polypeptide binding]; other site
266834017137	conserved gate region; other site
266834017138	putative PBP binding loops; other site
266834017139	ABC-ATPase subunit interface; other site
266834017140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017141	dimer interface [polypeptide binding]; other site
266834017142	conserved gate region; other site
266834017143	putative PBP binding loops; other site
266834017144	ABC-ATPase subunit interface; other site
266834017145	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834017146	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834017147	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
266834017148	non-specific DNA interactions [nucleotide binding]; other site
266834017149	DNA binding site [nucleotide binding]
266834017150	sequence specific DNA binding site [nucleotide binding]; other site
266834017151	putative cAMP binding site [chemical binding]; other site
266834017152	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
266834017153	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
266834017154	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
266834017155	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
266834017156	Active Sites [active]
266834017157	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
266834017158	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
266834017159	CysD dimerization site [polypeptide binding]; other site
266834017160	G1 box; other site
266834017161	putative GEF interaction site [polypeptide binding]; other site
266834017162	GTP/Mg2+ binding site [chemical binding]; other site
266834017163	Switch I region; other site
266834017164	G2 box; other site
266834017165	G3 box; other site
266834017166	Switch II region; other site
266834017167	G4 box; other site
266834017168	G5 box; other site
266834017169	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
266834017170	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
266834017171	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
266834017172	ligand-binding site [chemical binding]; other site
266834017173	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
266834017174	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
266834017175	active site
266834017176	Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387
266834017177	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
266834017178	active site
266834017179	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
266834017180	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
266834017181	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834017182	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834017183	NAD(P) binding site [chemical binding]; other site
266834017184	active site
266834017185	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
266834017186	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
266834017187	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
266834017188	putative ADP-binding pocket [chemical binding]; other site
266834017189	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
266834017190	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834017191	putative ADP-binding pocket [chemical binding]; other site
266834017192	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
266834017193	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
266834017194	NAD(P) binding site [chemical binding]; other site
266834017195	homodimer interface [polypeptide binding]; other site
266834017196	substrate binding site [chemical binding]; other site
266834017197	active site
266834017198	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
266834017199	HTH-like domain; Region: HTH_21; pfam13276
266834017200	Integrase core domain; Region: rve; pfam00665
266834017201	Integrase core domain; Region: rve_3; pfam13683
266834017202	Transposase; Region: HTH_Tnp_1; cl17663
266834017203	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834017204	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
266834017205	Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651
266834017206	putative active site [active]
266834017207	putative substrate binding site [chemical binding]; other site
266834017208	putative cosubstrate binding site; other site
266834017209	catalytic site [active]
266834017210	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
266834017211	active site
266834017212	hexamer interface [polypeptide binding]; other site
266834017213	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
266834017214	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
266834017215	Chain length determinant protein; Region: Wzz; pfam02706
266834017216	Chain length determinant protein; Region: Wzz; cl15801
266834017217	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
266834017218	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
266834017219	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
266834017220	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
266834017221	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
266834017222	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
266834017223	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
266834017224	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
266834017225	SLBB domain; Region: SLBB; pfam10531
266834017226	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
266834017227	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
266834017228	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
266834017229	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
266834017230	inhibitor-cofactor binding pocket; inhibition site
266834017231	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834017232	catalytic residue [active]
266834017233	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
266834017234	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834017235	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
266834017236	putative ADP-binding pocket [chemical binding]; other site
266834017237	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
266834017238	Mechanosensitive ion channel; Region: MS_channel; pfam00924
266834017239	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834017240	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
266834017241	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928
266834017242	NodB motif; other site
266834017243	putative active site [active]
266834017244	putative catalytic site [active]
266834017245	putative Zn binding site [ion binding]; other site
266834017246	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
266834017247	Protein of unknown function (DUF3095); Region: DUF3095; pfam11294
266834017248	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
266834017249	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
266834017250	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
266834017251	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
266834017252	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834017253	cyclase homology domain; Region: CHD; cd07302
266834017254	nucleotidyl binding site; other site
266834017255	metal binding site [ion binding]; metal-binding site
266834017256	dimer interface [polypeptide binding]; other site
266834017257	cyclase homology domain; Region: CHD; cd07302
266834017258	dimer interface [polypeptide binding]; other site
266834017259	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834017260	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
266834017261	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
266834017262	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834017263	Walker A/P-loop; other site
266834017264	ATP binding site [chemical binding]; other site
266834017265	Q-loop/lid; other site
266834017266	ABC transporter signature motif; other site
266834017267	Walker B; other site
266834017268	D-loop; other site
266834017269	H-loop/switch region; other site
266834017270	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834017271	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834017272	Walker A/P-loop; other site
266834017273	ATP binding site [chemical binding]; other site
266834017274	Q-loop/lid; other site
266834017275	ABC transporter signature motif; other site
266834017276	Walker B; other site
266834017277	D-loop; other site
266834017278	H-loop/switch region; other site
266834017279	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834017280	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
266834017281	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
266834017282	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834017283	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017284	dimer interface [polypeptide binding]; other site
266834017285	conserved gate region; other site
266834017286	putative PBP binding loops; other site
266834017287	ABC-ATPase subunit interface; other site
266834017288	microcin C ABC transporter permease; Provisional; Region: PRK15021
266834017289	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
266834017290	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017291	dimer interface [polypeptide binding]; other site
266834017292	conserved gate region; other site
266834017293	putative PBP binding loops; other site
266834017294	ABC-ATPase subunit interface; other site
266834017295	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
266834017296	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
266834017297	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
266834017298	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834017299	putative ADP-binding pocket [chemical binding]; other site
266834017300	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
266834017301	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
266834017302	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
266834017303	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834017304	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
266834017305	Walker A/P-loop; other site
266834017306	ATP binding site [chemical binding]; other site
266834017307	Q-loop/lid; other site
266834017308	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
266834017309	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834017310	ABC transporter signature motif; other site
266834017311	Walker B; other site
266834017312	D-loop; other site
266834017313	H-loop/switch region; other site
266834017314	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
266834017315	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
266834017316	ligand binding site [chemical binding]; other site
266834017317	flexible hinge region; other site
266834017318	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
266834017319	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834017320	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834017321	DNA binding site [nucleotide binding]
266834017322	domain linker motif; other site
266834017323	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
266834017324	dimerization interface [polypeptide binding]; other site
266834017325	ligand binding site [chemical binding]; other site
266834017326	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
266834017327	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
266834017328	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
266834017329	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017330	dimer interface [polypeptide binding]; other site
266834017331	conserved gate region; other site
266834017332	putative PBP binding loops; other site
266834017333	ABC-ATPase subunit interface; other site
266834017334	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834017335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017336	dimer interface [polypeptide binding]; other site
266834017337	conserved gate region; other site
266834017338	putative PBP binding loops; other site
266834017339	ABC-ATPase subunit interface; other site
266834017340	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
266834017341	active site
266834017342	tetramer interface [polypeptide binding]; other site
266834017343	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
266834017344	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
266834017345	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
266834017346	active site
266834017347	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
266834017348	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
266834017349	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
266834017350	metal binding site [ion binding]; metal-binding site
266834017351	putative dimer interface [polypeptide binding]; other site
266834017352	phosphoribosyltransferase; Provisional; Region: PRK06031
266834017353	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
266834017354	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
266834017355	Allantoicase [Nucleotide transport and metabolism]; Region: Alc; COG4266
266834017356	Allantoicase repeat; Region: Allantoicase; pfam03561
266834017357	Allantoicase repeat; Region: Allantoicase; pfam03561
266834017358	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
266834017359	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
266834017360	active site
266834017361	catalytic site [active]
266834017362	tetramer interface [polypeptide binding]; other site
266834017363	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
266834017364	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
266834017365	active site
266834017366	homotetramer interface [polypeptide binding]; other site
266834017367	Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630
266834017368	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834017369	catalytic loop [active]
266834017370	iron binding site [ion binding]; other site
266834017371	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
266834017372	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
266834017373	Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631
266834017374	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
266834017375	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834017376	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
266834017377	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
266834017378	XdhC Rossmann domain; Region: XdhC_C; pfam13478
266834017379	Predicted transcriptional regulators [Transcription]; Region: COG1733
266834017380	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
266834017381	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
266834017382	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
266834017383	NAD(P) binding site [chemical binding]; other site
266834017384	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834017385	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834017386	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834017387	putative effector binding pocket; other site
266834017388	dimerization interface [polypeptide binding]; other site
266834017389	Predicted membrane protein [Function unknown]; Region: COG3748
266834017390	Protein of unknown function (DUF989); Region: DUF989; pfam06181
266834017391	Cytochrome c; Region: Cytochrom_C; pfam00034
266834017392	guanine deaminase; Provisional; Region: PRK09228
266834017393	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
266834017394	active site
266834017395	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
266834017396	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
266834017397	putative dimer interface [polypeptide binding]; other site
266834017398	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
266834017399	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
266834017400	putative dimer interface [polypeptide binding]; other site
266834017401	Protein of unknown function (DUF982); Region: DUF982; pfam06169
266834017402	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
266834017403	Transglycosylase; Region: Transgly; pfam00912
266834017404	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
266834017405	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
266834017406	Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100
266834017407	putative binding site; other site
266834017408	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
266834017409	MG2 domain; Region: A2M_N; pfam01835
266834017410	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
266834017411	surface patch; other site
266834017412	thioester region; other site
266834017413	specificity defining residues; other site
266834017414	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
266834017415	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
266834017416	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
266834017417	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
266834017418	intersubunit interface [polypeptide binding]; other site
266834017419	active site
266834017420	catalytic residue [active]
266834017421	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
266834017422	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
266834017423	NAD(P) binding site [chemical binding]; other site
266834017424	catalytic residues [active]
266834017425	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
266834017426	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
266834017427	NAD(P) binding site [chemical binding]; other site
266834017428	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
266834017429	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
266834017430	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
266834017431	Amidinotransferase; Region: Amidinotransf; cl12043
266834017432	mercuric reductase; Validated; Region: PRK06370
266834017433	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
266834017434	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834017435	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
266834017436	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
266834017437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017438	dimer interface [polypeptide binding]; other site
266834017439	conserved gate region; other site
266834017440	ABC-ATPase subunit interface; other site
266834017441	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
266834017442	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834017443	Walker A/P-loop; other site
266834017444	ATP binding site [chemical binding]; other site
266834017445	Q-loop/lid; other site
266834017446	ABC transporter signature motif; other site
266834017447	Walker B; other site
266834017448	D-loop; other site
266834017449	H-loop/switch region; other site
266834017450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017451	dimer interface [polypeptide binding]; other site
266834017452	conserved gate region; other site
266834017453	putative PBP binding loops; other site
266834017454	ABC-ATPase subunit interface; other site
266834017455	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834017456	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834017457	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834017458	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017459	dimer interface [polypeptide binding]; other site
266834017460	conserved gate region; other site
266834017461	putative PBP binding loops; other site
266834017462	ABC-ATPase subunit interface; other site
266834017463	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834017464	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017465	dimer interface [polypeptide binding]; other site
266834017466	conserved gate region; other site
266834017467	putative PBP binding loops; other site
266834017468	ABC-ATPase subunit interface; other site
266834017469	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834017470	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
266834017471	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834017472	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834017473	Walker A/P-loop; other site
266834017474	ATP binding site [chemical binding]; other site
266834017475	Q-loop/lid; other site
266834017476	ABC transporter signature motif; other site
266834017477	Walker B; other site
266834017478	D-loop; other site
266834017479	H-loop/switch region; other site
266834017480	TOBE domain; Region: TOBE_2; pfam08402
266834017481	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
266834017482	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
266834017483	Coenzyme A binding pocket [chemical binding]; other site
266834017484	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
266834017485	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834017486	active site
266834017487	Uncharacterized conserved protein [Function unknown]; Region: COG5476
266834017488	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
266834017489	MlrC C-terminus; Region: MlrC_C; pfam07171
266834017490	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
266834017491	homotrimer interaction site [polypeptide binding]; other site
266834017492	putative active site [active]
266834017493	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
266834017494	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
266834017495	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
266834017496	putative active site [active]
266834017497	short chain dehydrogenase; Provisional; Region: PRK07074
266834017498	classical (c) SDRs; Region: SDR_c; cd05233
266834017499	NAD(P) binding site [chemical binding]; other site
266834017500	active site
266834017501	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
266834017502	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
266834017503	active site
266834017504	Uncharacterized conserved protein [Function unknown]; Region: COG5476
266834017505	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
266834017506	MlrC C-terminus; Region: MlrC_C; pfam07171
266834017507	sugar efflux transporter; Region: 2A0120; TIGR00899
266834017508	urocanate hydratase; Provisional; Region: PRK05414
266834017509	N-formylglutamate amidohydrolase; Region: FGase; cl01522
266834017510	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
266834017511	active sites [active]
266834017512	tetramer interface [polypeptide binding]; other site
266834017513	imidazolonepropionase; Validated; Region: PRK09356
266834017514	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
266834017515	active site
266834017516	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
266834017517	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
266834017518	putative active site [active]
266834017519	putative NTP binding site [chemical binding]; other site
266834017520	putative nucleic acid binding site [nucleotide binding]; other site
266834017521	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
266834017522	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
266834017523	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834017524	putative DNA binding site [nucleotide binding]; other site
266834017525	putative Zn2+ binding site [ion binding]; other site
266834017526	Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709
266834017527	active site
266834017528	Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454
266834017529	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
266834017530	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
266834017531	active site
266834017532	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
266834017533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017534	dimer interface [polypeptide binding]; other site
266834017535	conserved gate region; other site
266834017536	ABC-ATPase subunit interface; other site
266834017537	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
266834017538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017539	dimer interface [polypeptide binding]; other site
266834017540	conserved gate region; other site
266834017541	ABC-ATPase subunit interface; other site
266834017542	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
266834017543	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
266834017544	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
266834017545	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
266834017546	Walker A/P-loop; other site
266834017547	ATP binding site [chemical binding]; other site
266834017548	Q-loop/lid; other site
266834017549	ABC transporter signature motif; other site
266834017550	Walker B; other site
266834017551	D-loop; other site
266834017552	H-loop/switch region; other site
266834017553	Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598
266834017554	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834017555	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
266834017556	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834017557	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834017558	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
266834017559	dimerization interface [polypeptide binding]; other site
266834017560	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
266834017561	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
266834017562	FAD binding site [chemical binding]; other site
266834017563	substrate binding pocket [chemical binding]; other site
266834017564	catalytic base [active]
266834017565	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
266834017566	CoA-transferase family III; Region: CoA_transf_3; pfam02515
266834017567	heat shock protein 90; Provisional; Region: PRK05218
266834017568	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834017569	ATP binding site [chemical binding]; other site
266834017570	Mg2+ binding site [ion binding]; other site
266834017571	G-X-G motif; other site
266834017572	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
266834017573	propionate/acetate kinase; Provisional; Region: PRK12379
266834017574	succinic semialdehyde dehydrogenase; Region: PLN02278
266834017575	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
266834017576	tetramerization interface [polypeptide binding]; other site
266834017577	NAD(P) binding site [chemical binding]; other site
266834017578	catalytic residues [active]
266834017579	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
266834017580	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834017581	inhibitor-cofactor binding pocket; inhibition site
266834017582	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834017583	catalytic residue [active]
266834017584	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
266834017585	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
266834017586	DNA binding residues [nucleotide binding]
266834017587	dimer interface [polypeptide binding]; other site
266834017588	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
266834017589	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834017590	non-specific DNA binding site [nucleotide binding]; other site
266834017591	salt bridge; other site
266834017592	sequence-specific DNA binding site [nucleotide binding]; other site
266834017593	Cupin domain; Region: Cupin_2; pfam07883
266834017594	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
266834017595	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
266834017596	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
266834017597	active site
266834017598	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
266834017599	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
266834017600	active site
266834017601	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834017602	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
266834017603	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834017604	Walker A/P-loop; other site
266834017605	ATP binding site [chemical binding]; other site
266834017606	Q-loop/lid; other site
266834017607	ABC transporter signature motif; other site
266834017608	Walker B; other site
266834017609	D-loop; other site
266834017610	H-loop/switch region; other site
266834017611	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
266834017612	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
266834017613	intersubunit interface [polypeptide binding]; other site
266834017614	active site
266834017615	zinc binding site [ion binding]; other site
266834017616	Na+ binding site [ion binding]; other site
266834017617	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
266834017618	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
266834017619	peptide binding site [polypeptide binding]; other site
266834017620	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
266834017621	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017622	dimer interface [polypeptide binding]; other site
266834017623	conserved gate region; other site
266834017624	putative PBP binding loops; other site
266834017625	ABC-ATPase subunit interface; other site
266834017626	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
266834017627	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017628	dimer interface [polypeptide binding]; other site
266834017629	conserved gate region; other site
266834017630	ABC-ATPase subunit interface; other site
266834017631	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
266834017632	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834017633	Walker A/P-loop; other site
266834017634	ATP binding site [chemical binding]; other site
266834017635	Q-loop/lid; other site
266834017636	ABC transporter signature motif; other site
266834017637	Walker B; other site
266834017638	D-loop; other site
266834017639	H-loop/switch region; other site
266834017640	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
266834017641	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834017642	Walker A/P-loop; other site
266834017643	ATP binding site [chemical binding]; other site
266834017644	Q-loop/lid; other site
266834017645	ABC transporter signature motif; other site
266834017646	Walker B; other site
266834017647	D-loop; other site
266834017648	H-loop/switch region; other site
266834017649	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834017650	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
266834017651	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834017652	active site
266834017653	phosphorylation site [posttranslational modification]
266834017654	intermolecular recognition site; other site
266834017655	dimerization interface [polypeptide binding]; other site
266834017656	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834017657	Walker A motif; other site
266834017658	ATP binding site [chemical binding]; other site
266834017659	Walker B motif; other site
266834017660	arginine finger; other site
266834017661	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
266834017662	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
266834017663	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834017664	dimer interface [polypeptide binding]; other site
266834017665	phosphorylation site [posttranslational modification]
266834017666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834017667	ATP binding site [chemical binding]; other site
266834017668	Mg2+ binding site [ion binding]; other site
266834017669	G-X-G motif; other site
266834017670	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
266834017671	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
266834017672	Zn binding site [ion binding]; other site
266834017673	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
266834017674	Zn binding site [ion binding]; other site
266834017675	Predicted esterase [General function prediction only]; Region: COG0400
266834017676	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
266834017677	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
266834017678	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
266834017679	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
266834017680	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
266834017681	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
266834017682	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
266834017683	Walker A/P-loop; other site
266834017684	ATP binding site [chemical binding]; other site
266834017685	Q-loop/lid; other site
266834017686	ABC transporter signature motif; other site
266834017687	Walker B; other site
266834017688	D-loop; other site
266834017689	H-loop/switch region; other site
266834017690	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
266834017691	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
266834017692	Walker A/P-loop; other site
266834017693	ATP binding site [chemical binding]; other site
266834017694	Q-loop/lid; other site
266834017695	ABC transporter signature motif; other site
266834017696	Walker B; other site
266834017697	D-loop; other site
266834017698	H-loop/switch region; other site
266834017699	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
266834017700	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834017701	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834017702	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834017703	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
266834017704	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834017705	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834017706	dimer interface [polypeptide binding]; other site
266834017707	phosphorylation site [posttranslational modification]
266834017708	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834017709	ATP binding site [chemical binding]; other site
266834017710	Mg2+ binding site [ion binding]; other site
266834017711	G-X-G motif; other site
266834017712	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834017713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834017714	active site
266834017715	phosphorylation site [posttranslational modification]
266834017716	intermolecular recognition site; other site
266834017717	dimerization interface [polypeptide binding]; other site
266834017718	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834017719	DNA binding site [nucleotide binding]
266834017720	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
266834017721	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
266834017722	Sulfatase; Region: Sulfatase; pfam00884
266834017723	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
266834017724	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
266834017725	active site
266834017726	metal binding site [ion binding]; metal-binding site
266834017727	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834017728	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
266834017729	motif I; other site
266834017730	active site
266834017731	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
266834017732	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
266834017733	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834017734	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
266834017735	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834017736	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
266834017737	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834017738	S-adenosylmethionine binding site [chemical binding]; other site
266834017739	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
266834017740	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
266834017741	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
266834017742	active site
266834017743	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
266834017744	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
266834017745	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
266834017746	lipoyl-biotinyl attachment site [posttranslational modification]; other site
266834017747	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834017748	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
266834017749	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834017750	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
266834017751	Walker A/P-loop; other site
266834017752	ATP binding site [chemical binding]; other site
266834017753	Q-loop/lid; other site
266834017754	ABC transporter signature motif; other site
266834017755	Walker B; other site
266834017756	D-loop; other site
266834017757	H-loop/switch region; other site
266834017758	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
266834017759	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
266834017760	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834017761	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
266834017762	putative ADP-binding pocket [chemical binding]; other site
266834017763	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
266834017764	active site
266834017765	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834017766	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
266834017767	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
266834017768	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
266834017769	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
266834017770	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
266834017771	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
266834017772	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
266834017773	substrate binding site; other site
266834017774	tetramer interface; other site
266834017775	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
266834017776	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
266834017777	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
266834017778	NAD binding site [chemical binding]; other site
266834017779	substrate binding site [chemical binding]; other site
266834017780	homodimer interface [polypeptide binding]; other site
266834017781	active site
266834017782	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
266834017783	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
266834017784	NADP binding site [chemical binding]; other site
266834017785	active site
266834017786	putative substrate binding site [chemical binding]; other site
266834017787	Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406
266834017788	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
266834017789	BON domain; Region: BON; cl02771
266834017790	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
266834017791	Domain of unknown function DUF20; Region: UPF0118; pfam01594
266834017792	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
266834017793	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834017794	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834017795	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
266834017796	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
266834017797	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
266834017798	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
266834017799	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
266834017800	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
266834017801	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
266834017802	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834017803	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
266834017804	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834017805	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834017806	TM-ABC transporter signature motif; other site
266834017807	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834017808	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834017809	TM-ABC transporter signature motif; other site
266834017810	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834017811	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834017812	Walker A/P-loop; other site
266834017813	ATP binding site [chemical binding]; other site
266834017814	Q-loop/lid; other site
266834017815	ABC transporter signature motif; other site
266834017816	Walker B; other site
266834017817	D-loop; other site
266834017818	H-loop/switch region; other site
266834017819	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834017820	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834017821	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
266834017822	putative ligand binding site [chemical binding]; other site
266834017823	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834017824	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834017825	DNA binding site [nucleotide binding]
266834017826	domain linker motif; other site
266834017827	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
266834017828	putative dimerization interface [polypeptide binding]; other site
266834017829	putative ligand binding site [chemical binding]; other site
266834017830	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
266834017831	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
266834017832	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
266834017833	NADP binding site [chemical binding]; other site
266834017834	homodimer interface [polypeptide binding]; other site
266834017835	active site
266834017836	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
266834017837	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834017838	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834017839	DNA-binding site [nucleotide binding]; DNA binding site
266834017840	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
266834017841	DctM-like transporters; Region: DctM; pfam06808
266834017842	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
266834017843	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
266834017844	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
266834017845	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
266834017846	glucuronate isomerase; Reviewed; Region: PRK02925
266834017847	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
266834017848	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834017849	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834017850	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
266834017851	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
266834017852	Predicted membrane protein [Function unknown]; Region: COG4244
266834017853	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
266834017854	catalytic triad [active]
266834017855	conserved cis-peptide bond; other site
266834017856	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834017857	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834017858	Predicted membrane protein [Function unknown]; Region: COG2323
266834017859	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
266834017860	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
266834017861	Predicted membrane protein [Function unknown]; Region: COG4244
266834017862	Predicted membrane protein [Function unknown]; Region: COG3336
266834017863	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
266834017864	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
266834017865	Cytochrome c553 [Energy production and conversion]; Region: COG2863
266834017866	Cytochrome c; Region: Cytochrom_C; cl11414
266834017867	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
266834017868	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
266834017869	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
266834017870	Cytochrome c; Region: Cytochrom_C; pfam00034
266834017871	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
266834017872	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
266834017873	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
266834017874	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
266834017875	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
266834017876	D-pathway; other site
266834017877	Putative ubiquinol binding site [chemical binding]; other site
266834017878	Low-spin heme (heme b) binding site [chemical binding]; other site
266834017879	Putative water exit pathway; other site
266834017880	Binuclear center (heme o3/CuB) [ion binding]; other site
266834017881	K-pathway; other site
266834017882	Putative proton exit pathway; other site
266834017883	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834017884	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834017885	DNA binding site [nucleotide binding]
266834017886	domain linker motif; other site
266834017887	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
266834017888	dimerization interface [polypeptide binding]; other site
266834017889	ligand binding site [chemical binding]; other site
266834017890	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013
266834017891	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
266834017892	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
266834017893	substrate binding site [chemical binding]; other site
266834017894	ATP binding site [chemical binding]; other site
266834017895	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834017896	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834017897	TM-ABC transporter signature motif; other site
266834017898	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834017899	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834017900	Walker A/P-loop; other site
266834017901	ATP binding site [chemical binding]; other site
266834017902	Q-loop/lid; other site
266834017903	ABC transporter signature motif; other site
266834017904	Walker B; other site
266834017905	D-loop; other site
266834017906	H-loop/switch region; other site
266834017907	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834017908	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322
266834017909	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834017910	putative ligand binding site [chemical binding]; other site
266834017911	Uncharacterized conserved protein [Function unknown]; Region: COG3791
266834017912	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
266834017913	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
266834017914	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421
266834017915	active site
266834017916	short chain dehydrogenase; Provisional; Region: PRK12937
266834017917	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
266834017918	NADP binding site [chemical binding]; other site
266834017919	homodimer interface [polypeptide binding]; other site
266834017920	active site
266834017921	substrate binding site [chemical binding]; other site
266834017922	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
266834017923	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834017924	NAD(P) binding site [chemical binding]; other site
266834017925	active site
266834017926	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
266834017927	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834017928	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
266834017929	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834017930	DNA-binding site [nucleotide binding]; DNA binding site
266834017931	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
266834017932	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834017933	homodimer interface [polypeptide binding]; other site
266834017934	catalytic residue [active]
266834017935	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
266834017936	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834017937	substrate binding pocket [chemical binding]; other site
266834017938	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
266834017939	membrane-bound complex binding site; other site
266834017940	ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525
266834017941	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
266834017942	Walker A/P-loop; other site
266834017943	ATP binding site [chemical binding]; other site
266834017944	Q-loop/lid; other site
266834017945	ABC transporter signature motif; other site
266834017946	Walker B; other site
266834017947	D-loop; other site
266834017948	H-loop/switch region; other site
266834017949	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
266834017950	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834017951	dimer interface [polypeptide binding]; other site
266834017952	conserved gate region; other site
266834017953	putative PBP binding loops; other site
266834017954	ABC-ATPase subunit interface; other site
266834017955	SnoaL-like domain; Region: SnoaL_2; pfam12680
266834017956	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
266834017957	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834017958	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
266834017959	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
266834017960	PYR/PP interface [polypeptide binding]; other site
266834017961	dimer interface [polypeptide binding]; other site
266834017962	TPP binding site [chemical binding]; other site
266834017963	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
266834017964	Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013
266834017965	TPP-binding site; other site
266834017966	Predicted membrane protein [Function unknown]; Region: COG2855
266834017967	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
266834017968	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
266834017969	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834017970	DNA-binding site [nucleotide binding]; DNA binding site
266834017971	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
266834017972	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834017973	hydroxyglutarate oxidase; Provisional; Region: PRK11728
266834017974	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
266834017975	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
266834017976	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
266834017977	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
266834017978	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
266834017979	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834017980	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
266834017981	dimerization interface [polypeptide binding]; other site
266834017982	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
266834017983	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
266834017984	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
266834017985	PhoU domain; Region: PhoU; pfam01895
266834017986	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
266834017987	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
266834017988	catalytic residue [active]
266834017989	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
266834017990	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
266834017991	putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250
266834017992	Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146
266834017993	NAD(P) binding site [chemical binding]; other site
266834017994	catalytic residues [active]
266834017995	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
266834017996	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
266834017997	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
266834017998	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834017999	Walker A/P-loop; other site
266834018000	ATP binding site [chemical binding]; other site
266834018001	Q-loop/lid; other site
266834018002	ABC transporter signature motif; other site
266834018003	Walker B; other site
266834018004	D-loop; other site
266834018005	H-loop/switch region; other site
266834018006	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
266834018007	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834018008	dimer interface [polypeptide binding]; other site
266834018009	conserved gate region; other site
266834018010	putative PBP binding loops; other site
266834018011	ABC-ATPase subunit interface; other site
266834018012	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834018013	dimer interface [polypeptide binding]; other site
266834018014	conserved gate region; other site
266834018015	putative PBP binding loops; other site
266834018016	ABC-ATPase subunit interface; other site
266834018017	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
266834018018	active site
266834018019	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
266834018020	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
266834018021	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
266834018022	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
266834018023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834018024	active site
266834018025	phosphorylation site [posttranslational modification]
266834018026	intermolecular recognition site; other site
266834018027	dimerization interface [polypeptide binding]; other site
266834018028	LytTr DNA-binding domain; Region: LytTR; pfam04397
266834018029	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
266834018030	Histidine kinase; Region: His_kinase; pfam06580
266834018031	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
266834018032	ATP binding site [chemical binding]; other site
266834018033	Mg2+ binding site [ion binding]; other site
266834018034	G-X-G motif; other site
266834018035	Autotransporter beta-domain; Region: Autotransporter; pfam03797
266834018036	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
266834018037	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
266834018038	active site residue [active]
266834018039	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
266834018040	active site residue [active]
266834018041	Sulphur transport; Region: Sulf_transp; pfam04143
266834018042	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
266834018043	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
266834018044	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
266834018045	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
266834018046	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
266834018047	TrkA-N domain; Region: TrkA_N; pfam02254
266834018048	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
266834018049	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
266834018050	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834018051	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
266834018052	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
266834018053	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
266834018054	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834018055	catalytic loop [active]
266834018056	iron binding site [ion binding]; other site
266834018057	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
266834018058	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834018059	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834018060	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834018061	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834018062	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
266834018063	dimerization interface [polypeptide binding]; other site
266834018064	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834018065	dimer interface [polypeptide binding]; other site
266834018066	phosphorylation site [posttranslational modification]
266834018067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834018068	ATP binding site [chemical binding]; other site
266834018069	G-X-G motif; other site
266834018070	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834018071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834018072	active site
266834018073	phosphorylation site [posttranslational modification]
266834018074	intermolecular recognition site; other site
266834018075	dimerization interface [polypeptide binding]; other site
266834018076	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834018077	DNA binding site [nucleotide binding]
266834018078	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
266834018079	dimer interface [polypeptide binding]; other site
266834018080	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
266834018081	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
266834018082	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
266834018083	ring oligomerisation interface [polypeptide binding]; other site
266834018084	ATP/Mg binding site [chemical binding]; other site
266834018085	stacking interactions; other site
266834018086	hinge regions; other site
266834018087	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
266834018088	oligomerisation interface [polypeptide binding]; other site
266834018089	mobile loop; other site
266834018090	roof hairpin; other site
266834018091	Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425
266834018092	Cupin domain; Region: Cupin_2; cl17218
266834018093	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
266834018094	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
266834018095	putative active site [active]
266834018096	putative FMN binding site [chemical binding]; other site
266834018097	putative substrate binding site [chemical binding]; other site
266834018098	putative catalytic residue [active]
266834018099	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
266834018100	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
266834018101	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
266834018102	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
266834018103	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
266834018104	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
266834018105	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834018106	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
266834018107	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
266834018108	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834018109	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834018110	ATP binding site [chemical binding]; other site
266834018111	Mg2+ binding site [ion binding]; other site
266834018112	G-X-G motif; other site
266834018113	Major Facilitator Superfamily; Region: MFS_1; pfam07690
266834018114	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834018115	dimerization interface [polypeptide binding]; other site
266834018116	putative DNA binding site [nucleotide binding]; other site
266834018117	putative Zn2+ binding site [ion binding]; other site
266834018118	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
266834018119	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
266834018120	metal-binding site [ion binding]
266834018121	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
266834018122	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
266834018123	metal-binding site [ion binding]
266834018124	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
266834018125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834018126	motif II; other site
266834018127	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
266834018128	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
266834018129	DNA binding residues [nucleotide binding]
266834018130	dimer interface [polypeptide binding]; other site
266834018131	copper binding site [ion binding]; other site
266834018132	Predicted membrane protein [Function unknown]; Region: COG1238
266834018133	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
266834018134	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834018135	putative ADP-binding pocket [chemical binding]; other site
266834018136	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
266834018137	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
266834018138	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3930
266834018139	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
266834018140	glutathione synthetase; Provisional; Region: PRK12458
266834018141	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
266834018142	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834018143	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
266834018144	putative ligand binding site [chemical binding]; other site
266834018145	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834018146	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834018147	Walker A/P-loop; other site
266834018148	ATP binding site [chemical binding]; other site
266834018149	Q-loop/lid; other site
266834018150	ABC transporter signature motif; other site
266834018151	Walker B; other site
266834018152	D-loop; other site
266834018153	H-loop/switch region; other site
266834018154	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834018155	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834018156	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834018157	TM-ABC transporter signature motif; other site
266834018158	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834018159	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834018160	TM-ABC transporter signature motif; other site
266834018161	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834018162	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834018163	DNA-binding site [nucleotide binding]; DNA binding site
266834018164	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834018165	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834018166	Walker A/P-loop; other site
266834018167	ATP binding site [chemical binding]; other site
266834018168	Q-loop/lid; other site
266834018169	ABC transporter signature motif; other site
266834018170	Walker B; other site
266834018171	D-loop; other site
266834018172	H-loop/switch region; other site
266834018173	TOBE domain; Region: TOBE; cl01440
266834018174	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834018175	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834018176	dimer interface [polypeptide binding]; other site
266834018177	conserved gate region; other site
266834018178	ABC-ATPase subunit interface; other site
266834018179	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834018180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834018181	dimer interface [polypeptide binding]; other site
266834018182	conserved gate region; other site
266834018183	putative PBP binding loops; other site
266834018184	ABC-ATPase subunit interface; other site
266834018185	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834018186	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834018187	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
266834018188	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
266834018189	DNA interaction; other site
266834018190	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834018191	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834018192	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834018193	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834018194	DNA binding site [nucleotide binding]
266834018195	domain linker motif; other site
266834018196	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
266834018197	ligand binding site [chemical binding]; other site
266834018198	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
266834018199	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
266834018200	Predicted transcriptional regulator [Transcription]; Region: COG4189
266834018201	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834018202	putative DNA binding site [nucleotide binding]; other site
266834018203	dimerization interface [polypeptide binding]; other site
266834018204	putative Zn2+ binding site [ion binding]; other site
266834018205	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834018206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834018207	dimer interface [polypeptide binding]; other site
266834018208	conserved gate region; other site
266834018209	putative PBP binding loops; other site
266834018210	ABC-ATPase subunit interface; other site
266834018211	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834018212	dimer interface [polypeptide binding]; other site
266834018213	conserved gate region; other site
266834018214	putative PBP binding loops; other site
266834018215	ABC-ATPase subunit interface; other site
266834018216	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834018217	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
266834018218	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834018219	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834018220	Walker A/P-loop; other site
266834018221	ATP binding site [chemical binding]; other site
266834018222	Q-loop/lid; other site
266834018223	ABC transporter signature motif; other site
266834018224	Walker B; other site
266834018225	D-loop; other site
266834018226	H-loop/switch region; other site
266834018227	TOBE domain; Region: TOBE_2; pfam08402
266834018228	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
266834018229	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
266834018230	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
266834018231	Peptidase family M50; Region: Peptidase_M50; pfam02163
266834018232	active site
266834018233	putative substrate binding region [chemical binding]; other site
266834018234	FOG: CBS domain [General function prediction only]; Region: COG0517
266834018235	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639
266834018236	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
266834018237	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
266834018238	protein binding site [polypeptide binding]; other site
266834018239	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
266834018240	Active site serine [active]
266834018241	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834018242	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834018243	TM-ABC transporter signature motif; other site
266834018244	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
266834018245	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834018246	Walker A/P-loop; other site
266834018247	ATP binding site [chemical binding]; other site
266834018248	Q-loop/lid; other site
266834018249	ABC transporter signature motif; other site
266834018250	Walker B; other site
266834018251	D-loop; other site
266834018252	H-loop/switch region; other site
266834018253	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
266834018254	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
266834018255	ligand binding site [chemical binding]; other site
266834018256	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
266834018257	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
266834018258	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
266834018259	active site
266834018260	catalytic residues [active]
266834018261	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834018262	PAS domain; Region: PAS_9; pfam13426
266834018263	putative active site [active]
266834018264	heme pocket [chemical binding]; other site
266834018265	PAS domain S-box; Region: sensory_box; TIGR00229
266834018266	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834018267	putative active site [active]
266834018268	heme pocket [chemical binding]; other site
266834018269	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
266834018270	GAF domain; Region: GAF; pfam01590
266834018271	PAS fold; Region: PAS_4; pfam08448
266834018272	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834018273	PAS fold; Region: PAS_3; pfam08447
266834018274	putative active site [active]
266834018275	heme pocket [chemical binding]; other site
266834018276	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
266834018277	HWE histidine kinase; Region: HWE_HK; pfam07536
266834018278	Response regulator receiver domain; Region: Response_reg; pfam00072
266834018279	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834018280	active site
266834018281	phosphorylation site [posttranslational modification]
266834018282	intermolecular recognition site; other site
266834018283	dimerization interface [polypeptide binding]; other site
266834018284	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
266834018285	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834018286	non-specific DNA binding site [nucleotide binding]; other site
266834018287	salt bridge; other site
266834018288	sequence-specific DNA binding site [nucleotide binding]; other site
266834018289	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
266834018290	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
266834018291	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
266834018292	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
266834018293	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
266834018294	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
266834018295	active site
266834018296	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
266834018297	Ligand Binding Site [chemical binding]; other site
266834018298	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834018299	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
266834018300	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
266834018301	Walker A/P-loop; other site
266834018302	ATP binding site [chemical binding]; other site
266834018303	Q-loop/lid; other site
266834018304	ABC transporter signature motif; other site
266834018305	Walker B; other site
266834018306	D-loop; other site
266834018307	H-loop/switch region; other site
266834018308	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
266834018309	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
266834018310	NAD binding site [chemical binding]; other site
266834018311	homodimer interface [polypeptide binding]; other site
266834018312	active site
266834018313	substrate binding site [chemical binding]; other site
266834018314	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
266834018315	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
266834018316	O-Antigen ligase; Region: Wzy_C; pfam04932
266834018317	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
266834018318	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
266834018319	SLBB domain; Region: SLBB; pfam10531
266834018320	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
266834018321	Exopolysaccharide production repressor; Region: SyrA; pfam11089
266834018322	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
266834018323	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
266834018324	active site
266834018325	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
266834018326	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
266834018327	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
266834018328	active site
266834018329	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
266834018330	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
266834018331	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
266834018332	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
266834018333	Catalytic site; other site
266834018334	Acyltransferase family; Region: Acyl_transf_3; pfam01757
266834018335	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
266834018336	lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175
266834018337	active site
266834018338	active site
266834018339	catalytic residues [active]
266834018340	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
266834018341	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
266834018342	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
266834018343	Ligand binding site; other site
266834018344	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
266834018345	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
266834018346	active site
266834018347	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
266834018348	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
266834018349	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
266834018350	active site
266834018351	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
266834018352	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
266834018353	active site
266834018354	tetramer interface; other site
266834018355	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
266834018356	Chain length determinant protein; Region: Wzz; pfam02706
266834018357	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
266834018358	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
266834018359	substrate binding site [chemical binding]; other site
266834018360	dimer interface [polypeptide binding]; other site
266834018361	ATP binding site [chemical binding]; other site
266834018362	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
266834018363	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
266834018364	dimer interface [polypeptide binding]; other site
266834018365	decamer (pentamer of dimers) interface [polypeptide binding]; other site
266834018366	catalytic triad [active]
266834018367	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
266834018368	Beta-lactamase; Region: Beta-lactamase; pfam00144
266834018369	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
266834018370	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
266834018371	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
266834018372	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
266834018373	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834018374	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834018375	DNA binding site [nucleotide binding]
266834018376	domain linker motif; other site
266834018377	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
266834018378	ligand binding site [chemical binding]; other site
266834018379	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
266834018380	Trehalase; Region: Trehalase; cl17346
266834018381	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834018382	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834018383	dimer interface [polypeptide binding]; other site
266834018384	conserved gate region; other site
266834018385	putative PBP binding loops; other site
266834018386	ABC-ATPase subunit interface; other site
266834018387	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834018388	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834018389	dimer interface [polypeptide binding]; other site
266834018390	conserved gate region; other site
266834018391	putative PBP binding loops; other site
266834018392	ABC-ATPase subunit interface; other site
266834018393	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834018394	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834018395	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834018396	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834018397	Walker A/P-loop; other site
266834018398	ATP binding site [chemical binding]; other site
266834018399	Q-loop/lid; other site
266834018400	ABC transporter signature motif; other site
266834018401	Walker B; other site
266834018402	D-loop; other site
266834018403	H-loop/switch region; other site
266834018404	TOBE domain; Region: TOBE_2; pfam08402
266834018405	hypothetical protein; Provisional; Region: PRK06148
266834018406	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
266834018407	active site
266834018408	ATP binding site [chemical binding]; other site
266834018409	substrate binding site [chemical binding]; other site
266834018410	Peptidase family M23; Region: Peptidase_M23; pfam01551
266834018411	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
266834018412	inhibitor-cofactor binding pocket; inhibition site
266834018413	pyridoxal 5'-phosphate binding site [chemical binding]; other site
266834018414	catalytic residue [active]
266834018415	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
266834018416	C factor cell-cell signaling protein; Provisional; Region: PRK09009
266834018417	NADP binding site [chemical binding]; other site
266834018418	homodimer interface [polypeptide binding]; other site
266834018419	active site
266834018420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834018421	dimer interface [polypeptide binding]; other site
266834018422	conserved gate region; other site
266834018423	putative PBP binding loops; other site
266834018424	ABC-ATPase subunit interface; other site
266834018425	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
266834018426	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834018427	substrate binding pocket [chemical binding]; other site
266834018428	membrane-bound complex binding site; other site
266834018429	hinge residues; other site
266834018430	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834018431	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834018432	DNA binding site [nucleotide binding]
266834018433	domain linker motif; other site
266834018434	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
266834018435	ligand binding site [chemical binding]; other site
266834018436	Acyl dehydratase [Lipid metabolism]; Region: MaoC; COG2030
266834018437	active site 2 [active]
266834018438	active site 1 [active]
266834018439	DctM-like transporters; Region: DctM; pfam06808
266834018440	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
266834018441	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
266834018442	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
266834018443	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
266834018444	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
266834018445	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834018446	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
266834018447	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
266834018448	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
266834018449	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
266834018450	[2Fe-2S] cluster binding site [ion binding]; other site
266834018451	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
266834018452	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
266834018453	[4Fe-4S] binding site [ion binding]; other site
266834018454	molybdopterin cofactor binding site; other site
266834018455	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
266834018456	molybdopterin cofactor binding site; other site
266834018457	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
266834018458	siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470
266834018459	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
266834018460	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
266834018461	Uroporphyrinogen-III methylase [Coenzyme metabolism]; Region: CysG; COG0007
266834018462	homodimer interface [polypeptide binding]; other site
266834018463	active site
266834018464	SAM binding site [chemical binding]; other site
266834018465	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
266834018466	nudix motif; other site
266834018467	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
266834018468	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
266834018469	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
266834018470	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
266834018471	dimer interface [polypeptide binding]; other site
266834018472	active site residues [active]
266834018473	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
266834018474	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
266834018475	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
266834018476	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
266834018477	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
266834018478	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
266834018479	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
266834018480	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
266834018481	active site
266834018482	Predicted transcriptional regulator [Transcription]; Region: COG1959
266834018483	Transcriptional regulator; Region: Rrf2; pfam02082
266834018484	GTP-binding protein Der; Reviewed; Region: PRK00093
266834018485	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
266834018486	G1 box; other site
266834018487	GTP/Mg2+ binding site [chemical binding]; other site
266834018488	Switch I region; other site
266834018489	G2 box; other site
266834018490	Switch II region; other site
266834018491	G3 box; other site
266834018492	G4 box; other site
266834018493	G5 box; other site
266834018494	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
266834018495	G1 box; other site
266834018496	GTP/Mg2+ binding site [chemical binding]; other site
266834018497	Switch I region; other site
266834018498	G2 box; other site
266834018499	G3 box; other site
266834018500	Switch II region; other site
266834018501	G4 box; other site
266834018502	G5 box; other site
266834018503	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
266834018504	Predicted membrane protein [Function unknown]; Region: COG4094
266834018505	Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976
266834018506	NodB motif; other site
266834018507	putative active site [active]
266834018508	putative catalytic site [active]
266834018509	microcin B17 transporter; Reviewed; Region: PRK11098
266834018510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834018511	putative substrate translocation pore; other site
266834018512	D-galactonate transporter; Region: 2A0114; TIGR00893
266834018513	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
266834018514	active site
266834018515	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
266834018516	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
266834018517	Uncharacterized conserved protein [Function unknown]; Region: COG5649
266834018518	Uncharacterized conserved protein [Function unknown]; Region: COG5649
266834018519	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
266834018520	putative hydrophobic ligand binding site [chemical binding]; other site
266834018521	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834018522	dimerization interface [polypeptide binding]; other site
266834018523	putative DNA binding site [nucleotide binding]; other site
266834018524	putative Zn2+ binding site [ion binding]; other site
266834018525	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
266834018526	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
266834018527	N- and C-terminal domain interface [polypeptide binding]; other site
266834018528	active site
266834018529	MgATP binding site [chemical binding]; other site
266834018530	catalytic site [active]
266834018531	metal binding site [ion binding]; metal-binding site
266834018532	glycerol binding site [chemical binding]; other site
266834018533	homotetramer interface [polypeptide binding]; other site
266834018534	homodimer interface [polypeptide binding]; other site
266834018535	FBP binding site [chemical binding]; other site
266834018536	protein IIAGlc interface [polypeptide binding]; other site
266834018537	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
266834018538	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
266834018539	NAD binding site [chemical binding]; other site
266834018540	homotetramer interface [polypeptide binding]; other site
266834018541	homodimer interface [polypeptide binding]; other site
266834018542	substrate binding site [chemical binding]; other site
266834018543	active site
266834018544	Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630
266834018545	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834018546	catalytic loop [active]
266834018547	iron binding site [ion binding]; other site
266834018548	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
266834018549	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
266834018550	Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631
266834018551	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
266834018552	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
266834018553	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
266834018554	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834018555	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
266834018556	dimerization interface [polypeptide binding]; other site
266834018557	substrate binding pocket [chemical binding]; other site
266834018558	Predicted membrane protein [Function unknown]; Region: COG3748
266834018559	Protein of unknown function (DUF989); Region: DUF989; pfam06181
266834018560	Cytochrome c; Region: Cytochrom_C; pfam00034
266834018561	guanine deaminase; Provisional; Region: PRK09228
266834018562	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
266834018563	active site
266834018564	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
266834018565	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
266834018566	active site
266834018567	substrate binding site [chemical binding]; other site
266834018568	FMN binding site [chemical binding]; other site
266834018569	putative catalytic residues [active]
266834018570	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
266834018571	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
266834018572	DNA binding residues [nucleotide binding]
266834018573	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
266834018574	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
266834018575	Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783
266834018576	N- and C-terminal domain interface [polypeptide binding]; other site
266834018577	active site
266834018578	MgATP binding site [chemical binding]; other site
266834018579	catalytic site [active]
266834018580	metal binding site [ion binding]; metal-binding site
266834018581	putative carbohydrate binding site [chemical binding]; other site
266834018582	putative homodimer interface [polypeptide binding]; other site
266834018583	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
266834018584	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
266834018585	putative NAD(P) binding site [chemical binding]; other site
266834018586	catalytic Zn binding site [ion binding]; other site
266834018587	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834018588	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834018589	TM-ABC transporter signature motif; other site
266834018590	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834018591	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834018592	Walker A/P-loop; other site
266834018593	ATP binding site [chemical binding]; other site
266834018594	Q-loop/lid; other site
266834018595	ABC transporter signature motif; other site
266834018596	Walker B; other site
266834018597	D-loop; other site
266834018598	H-loop/switch region; other site
266834018599	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834018600	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318
266834018601	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
266834018602	putative ligand binding site [chemical binding]; other site
266834018603	glucose-6-phosphate isomerase; Provisional; Region: PRK04190
266834018604	Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560
266834018605	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
266834018606	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
266834018607	FMN binding site [chemical binding]; other site
266834018608	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
266834018609	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834018610	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
266834018611	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
266834018612	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
266834018613	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
266834018614	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
266834018615	Mechanosensitive ion channel; Region: MS_channel; pfam00924
266834018616	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
266834018617	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
266834018618	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834018619	NAD(P) binding site [chemical binding]; other site
266834018620	active site
266834018621	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
266834018622	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
266834018623	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834018624	PAS fold; Region: PAS_3; pfam08447
266834018625	putative active site [active]
266834018626	heme pocket [chemical binding]; other site
266834018627	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834018628	PAS domain; Region: PAS_9; pfam13426
266834018629	putative active site [active]
266834018630	heme pocket [chemical binding]; other site
266834018631	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834018632	PAS fold; Region: PAS_3; pfam08447
266834018633	putative active site [active]
266834018634	heme pocket [chemical binding]; other site
266834018635	PAS fold; Region: PAS_3; pfam08447
266834018636	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
266834018637	putative active site [active]
266834018638	heme pocket [chemical binding]; other site
266834018639	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834018640	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834018641	ATP binding site [chemical binding]; other site
266834018642	Mg2+ binding site [ion binding]; other site
266834018643	G-X-G motif; other site
266834018644	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
266834018645	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834018646	active site
266834018647	phosphorylation site [posttranslational modification]
266834018648	intermolecular recognition site; other site
266834018649	dimerization interface [polypeptide binding]; other site
266834018650	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834018651	DNA binding residues [nucleotide binding]
266834018652	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834018653	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834018654	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
266834018655	putative effector binding pocket; other site
266834018656	dimerization interface [polypeptide binding]; other site
266834018657	short chain dehydrogenase; Provisional; Region: PRK06500
266834018658	classical (c) SDRs; Region: SDR_c; cd05233
266834018659	NAD(P) binding site [chemical binding]; other site
266834018660	active site
266834018661	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
266834018662	active site
266834018663	homotetramer interface [polypeptide binding]; other site
266834018664	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
266834018665	ureidoglycolate hydrolase; Provisional; Region: PRK03606
266834018666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
266834018667	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
266834018668	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
266834018669	active site
266834018670	catalytic site [active]
266834018671	tetramer interface [polypeptide binding]; other site
266834018672	Protein of unknown function (DUF1045); Region: DUF1045; pfam06299
266834018673	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
266834018674	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
266834018675	Uncharacterized conserved protein [Function unknown]; Region: COG4121
266834018676	Protein required for attachment to host cells [Cell motility and secretion]; Region: COG5622
266834018677	helicase 45; Provisional; Region: PTZ00424
266834018678	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
266834018679	ATP binding site [chemical binding]; other site
266834018680	Mg++ binding site [ion binding]; other site
266834018681	motif III; other site
266834018682	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
266834018683	nucleotide binding region [chemical binding]; other site
266834018684	ATP-binding site [chemical binding]; other site
266834018685	Predicted metal-binding protein [General function prediction only]; Region: COG3019
266834018686	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
266834018687	YtkA-like; Region: YtkA; pfam13115
266834018688	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
266834018689	EamA-like transporter family; Region: EamA; pfam00892
266834018690	Uncharacterized conserved protein [Function unknown]; Region: COG2308
266834018691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
266834018692	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
266834018693	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
266834018694	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
266834018695	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
266834018696	dihydroxy-acid dehydratase; Validated; Region: PRK06131
266834018697	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
266834018698	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
266834018699	NAD(P) binding site [chemical binding]; other site
266834018700	catalytic residues [active]
266834018701	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
266834018702	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
266834018703	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834018704	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834018705	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834018706	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834018707	TM-ABC transporter signature motif; other site
266834018708	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834018709	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834018710	ATP binding site [chemical binding]; other site
266834018711	Q-loop/lid; other site
266834018712	ABC transporter signature motif; other site
266834018713	Walker B; other site
266834018714	D-loop; other site
266834018715	H-loop/switch region; other site
266834018716	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834018717	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
266834018718	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
266834018719	putative ligand binding site [chemical binding]; other site
266834018720	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834018721	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834018722	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
266834018723	putative dimerization interface [polypeptide binding]; other site
266834018724	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
266834018725	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
266834018726	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
266834018727	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
266834018728	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
266834018729	PAS domain S-box; Region: sensory_box; TIGR00229
266834018730	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
266834018731	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
266834018732	metal binding site [ion binding]; metal-binding site
266834018733	active site
266834018734	I-site; other site
266834018735	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834018736	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834018737	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
266834018738	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
266834018739	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
266834018740	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
266834018741	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
266834018742	putative ligand binding site [chemical binding]; other site
266834018743	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834018744	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834018745	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834018746	TM-ABC transporter signature motif; other site
266834018747	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
266834018748	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834018749	Walker A/P-loop; other site
266834018750	ATP binding site [chemical binding]; other site
266834018751	Q-loop/lid; other site
266834018752	ABC transporter signature motif; other site
266834018753	Walker B; other site
266834018754	D-loop; other site
266834018755	H-loop/switch region; other site
266834018756	Homeodomain-like domain; Region: HTH_23; cl17451
266834018757	putative transposase OrfB; Reviewed; Region: PHA02517
266834018758	Homeodomain-like domain; Region: HTH_32; pfam13565
266834018759	Integrase core domain; Region: rve; pfam00665
266834018760	Integrase core domain; Region: rve_3; pfam13683
266834018761	Predicted small integral membrane protein [Function unknown]; Region: COG5478
266834018762	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
266834018763	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
266834018764	active site
266834018765	DNA binding site [nucleotide binding]
266834018766	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
266834018767	DNA binding site [nucleotide binding]
266834018768	Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313
266834018769	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
266834018770	Sulfatase; Region: Sulfatase; pfam00884
266834018771	Transposase; Region: HTH_Tnp_1; cl17663
266834018772	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
266834018773	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
266834018774	HTH-like domain; Region: HTH_21; pfam13276
266834018775	Integrase core domain; Region: rve; pfam00665
266834018776	Integrase core domain; Region: rve_3; pfam13683
266834018777	Predicted chitinase [General function prediction only]; Region: COG3179
266834018778	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
266834018779	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
266834018780	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
266834018781	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
266834018782	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
266834018783	catalytic triad [active]
266834018784	dimer interface [polypeptide binding]; other site
266834018785	conserved cis-peptide bond; other site
266834018786	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
266834018787	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
266834018788	putative DNA binding site [nucleotide binding]; other site
266834018789	putative homodimer interface [polypeptide binding]; other site
266834018790	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
266834018791	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
266834018792	putative DNA binding site [nucleotide binding]; other site
266834018793	putative homodimer interface [polypeptide binding]; other site
266834018794	Methyltransferase domain; Region: Methyltransf_23; pfam13489
266834018795	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834018796	S-adenosylmethionine binding site [chemical binding]; other site
266834018797	Uncharacterized conserved protein [Function unknown]; Region: COG3189
266834018798	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
266834018799	Ca2+ binding site [ion binding]; other site
266834018800	tyrosine decarboxylase; Region: PLN02880
266834018801	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
266834018802	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
266834018803	catalytic residue [active]
266834018804	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
266834018805	FAD binding domain; Region: FAD_binding_4; pfam01565
266834018806	Berberine and berberine like; Region: BBE; pfam08031
266834018807	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
266834018808	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
266834018809	substrate binding site; other site
266834018810	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
266834018811	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
266834018812	NAD binding site [chemical binding]; other site
266834018813	homotetramer interface [polypeptide binding]; other site
266834018814	homodimer interface [polypeptide binding]; other site
266834018815	substrate binding site [chemical binding]; other site
266834018816	active site
266834018817	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
266834018818	Methyltransferase domain; Region: Methyltransf_23; pfam13489
266834018819	Methyltransferase domain; Region: Methyltransf_12; pfam08242
266834018820	S-adenosylmethionine binding site [chemical binding]; other site
266834018821	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
266834018822	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
266834018823	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834018824	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834018825	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834018826	L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160
266834018827	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
266834018828	hexamer (dimer of trimers) interface [polypeptide binding]; other site
266834018829	substrate binding site [chemical binding]; other site
266834018830	trimer interface [polypeptide binding]; other site
266834018831	Mn binding site [ion binding]; other site
266834018832	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834018833	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
266834018834	ligand binding site [chemical binding]; other site
266834018835	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834018836	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834018837	Walker A/P-loop; other site
266834018838	ATP binding site [chemical binding]; other site
266834018839	Q-loop/lid; other site
266834018840	ABC transporter signature motif; other site
266834018841	Walker B; other site
266834018842	D-loop; other site
266834018843	H-loop/switch region; other site
266834018844	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834018845	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834018846	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834018847	TM-ABC transporter signature motif; other site
266834018848	Predicted acyl esterases [General function prediction only]; Region: COG2936
266834018849	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
266834018850	Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510
266834018851	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
266834018852	extended (e) SDRs; Region: SDR_e; cd08946
266834018853	NAD(P) binding site [chemical binding]; other site
266834018854	active site
266834018855	substrate binding site [chemical binding]; other site
266834018856	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
266834018857	putative trimer interface [polypeptide binding]; other site
266834018858	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
266834018859	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
266834018860	trimer interface [polypeptide binding]; other site
266834018861	active site
266834018862	substrate binding site [chemical binding]; other site
266834018863	putative CoA binding site [chemical binding]; other site
266834018864	CoA binding site [chemical binding]; other site
266834018865	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
266834018866	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
266834018867	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
266834018868	Walker A/P-loop; other site
266834018869	ATP binding site [chemical binding]; other site
266834018870	Q-loop/lid; other site
266834018871	ABC transporter signature motif; other site
266834018872	Walker B; other site
266834018873	D-loop; other site
266834018874	H-loop/switch region; other site
266834018875	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
266834018876	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
266834018877	ABC-ATPase subunit  interface; other site
266834018878	dimer interface [polypeptide binding]; other site
266834018879	putative PBP binding regions; other site
266834018880	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
266834018881	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
266834018882	intersubunit interface [polypeptide binding]; other site
266834018883	Methyltransferase domain; Region: Methyltransf_23; pfam13489
266834018884	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834018885	S-adenosylmethionine binding site [chemical binding]; other site
266834018886	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834018887	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834018888	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
266834018889	dimerization interface [polypeptide binding]; other site
266834018890	allantoate amidohydrolase; Reviewed; Region: PRK12893
266834018891	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
266834018892	active site
266834018893	metal binding site [ion binding]; metal-binding site
266834018894	dimer interface [polypeptide binding]; other site
266834018895	DctM-like transporters; Region: DctM; pfam06808
266834018896	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
266834018897	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
266834018898	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
266834018899	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
266834018900	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
266834018901	homotrimer interaction site [polypeptide binding]; other site
266834018902	putative active site [active]
266834018903	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
266834018904	FOG: CBS domain [General function prediction only]; Region: COG0517
266834018905	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
266834018906	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
266834018907	BON domain; Region: BON; pfam04972
266834018908	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
266834018909	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
266834018910	active site
266834018911	DNA binding site [nucleotide binding]
266834018912	Int/Topo IB signature motif; other site
266834018913	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
266834018914	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
266834018915	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
266834018916	active site
266834018917	catalytic site [active]
266834018918	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
266834018919	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
266834018920	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
266834018921	catalytic site [active]
266834018922	active site
266834018923	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
266834018924	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
266834018925	Fe-S cluster binding site [ion binding]; other site
266834018926	active site
266834018927	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
266834018928	glutathione s-transferase; Provisional; Region: PTZ00057
266834018929	GSH binding site (G-site) [chemical binding]; other site
266834018930	C-terminal domain interface [polypeptide binding]; other site
266834018931	dimer interface [polypeptide binding]; other site
266834018932	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
266834018933	N-terminal domain interface [polypeptide binding]; other site
266834018934	substrate binding pocket (H-site) [chemical binding]; other site
266834018935	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
266834018936	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
266834018937	Uncharacterized conserved protein [Function unknown]; Region: COG1415
266834018938	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834018939	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834018940	dimer interface [polypeptide binding]; other site
266834018941	conserved gate region; other site
266834018942	putative PBP binding loops; other site
266834018943	ABC-ATPase subunit interface; other site
266834018944	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834018945	dimer interface [polypeptide binding]; other site
266834018946	conserved gate region; other site
266834018947	putative PBP binding loops; other site
266834018948	ABC-ATPase subunit interface; other site
266834018949	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
266834018950	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834018951	Walker A/P-loop; other site
266834018952	ATP binding site [chemical binding]; other site
266834018953	Q-loop/lid; other site
266834018954	ABC transporter signature motif; other site
266834018955	Walker B; other site
266834018956	D-loop; other site
266834018957	H-loop/switch region; other site
266834018958	TOBE domain; Region: TOBE_2; pfam08402
266834018959	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834018960	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834018961	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
266834018962	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
266834018963	substrate binding site [chemical binding]; other site
266834018964	ATP binding site [chemical binding]; other site
266834018965	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
266834018966	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
266834018967	NAD binding site [chemical binding]; other site
266834018968	sugar binding site [chemical binding]; other site
266834018969	divalent metal binding site [ion binding]; other site
266834018970	tetramer (dimer of dimers) interface [polypeptide binding]; other site
266834018971	dimer interface [polypeptide binding]; other site
266834018972	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
266834018973	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834018974	DNA-binding site [nucleotide binding]; DNA binding site
266834018975	UTRA domain; Region: UTRA; pfam07702
266834018976	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
266834018977	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834018978	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834018979	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
266834018980	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
266834018981	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
266834018982	Walker A/P-loop; other site
266834018983	ATP binding site [chemical binding]; other site
266834018984	Q-loop/lid; other site
266834018985	ABC transporter signature motif; other site
266834018986	Walker B; other site
266834018987	D-loop; other site
266834018988	H-loop/switch region; other site
266834018989	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899
266834018990	Protein of unknown function (DUF982); Region: DUF982; pfam06169
266834018991	Protein of unknown function (DUF982); Region: DUF982; pfam06169
266834018992	Protein of unknown function (DUF982); Region: DUF982; pfam06169
266834018993	Predicted small integral membrane protein [Function unknown]; Region: COG5478
266834018994	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834018995	classical (c) SDRs; Region: SDR_c; cd05233
266834018996	NAD(P) binding site [chemical binding]; other site
266834018997	active site
266834018998	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
266834018999	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
266834019000	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
266834019001	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
266834019002	putative active site [active]
266834019003	putative NTP binding site [chemical binding]; other site
266834019004	putative nucleic acid binding site [nucleotide binding]; other site
266834019005	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
266834019006	Protein of unknown function (DUF982); Region: DUF982; pfam06169
266834019007	FOG: CBS domain [General function prediction only]; Region: COG0517
266834019008	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
266834019009	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
266834019010	RNA polymerase sigma factor; Provisional; Region: PRK12547
266834019011	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
266834019012	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834019013	DNA binding residues [nucleotide binding]
266834019014	metabolite-proton symporter; Region: 2A0106; TIGR00883
266834019015	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834019016	putative substrate translocation pore; other site
266834019017	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
266834019018	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
266834019019	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
266834019020	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
266834019021	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
266834019022	D-pathway; other site
266834019023	Putative ubiquinol binding site [chemical binding]; other site
266834019024	Low-spin heme (heme b) binding site [chemical binding]; other site
266834019025	Putative water exit pathway; other site
266834019026	Binuclear center (heme o3/CuB) [ion binding]; other site
266834019027	K-pathway; other site
266834019028	Putative proton exit pathway; other site
266834019029	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
266834019030	Subunit I/III interface [polypeptide binding]; other site
266834019031	Subunit III/IV interface [polypeptide binding]; other site
266834019032	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
266834019033	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
266834019034	Protein of unknown function (DUF992); Region: DUF992; pfam06186
266834019035	Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664
266834019036	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
266834019037	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
266834019038	putative DNA binding site [nucleotide binding]; other site
266834019039	putative Zn2+ binding site [ion binding]; other site
266834019040	AsnC family; Region: AsnC_trans_reg; pfam01037
266834019041	ornithine cyclodeaminase; Validated; Region: PRK07589
266834019042	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
266834019043	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
266834019044	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
266834019045	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
266834019046	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834019047	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834019048	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
266834019049	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
266834019050	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
266834019051	active site
266834019052	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
266834019053	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
266834019054	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
266834019055	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
266834019056	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
266834019057	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
266834019058	putative active site [active]
266834019059	putative metal binding site [ion binding]; other site
266834019060	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
266834019061	O-Antigen ligase; Region: Wzy_C; pfam04932
266834019062	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
266834019063	Chain length determinant protein; Region: Wzz; cl15801
266834019064	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
266834019065	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
266834019066	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
266834019067	inhibitor site; inhibition site
266834019068	active site
266834019069	dimer interface [polypeptide binding]; other site
266834019070	catalytic residue [active]
266834019071	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
266834019072	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
266834019073	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
266834019074	homodimer interface [polypeptide binding]; other site
266834019075	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
266834019076	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
266834019077	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
266834019078	S-adenosylmethionine binding site [chemical binding]; other site
266834019079	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
266834019080	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
266834019081	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
266834019082	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
266834019083	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
266834019084	Histidine kinase; Region: HisKA_3; pfam07730
266834019085	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834019086	ATP binding site [chemical binding]; other site
266834019087	Mg2+ binding site [ion binding]; other site
266834019088	G-X-G motif; other site
266834019089	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
266834019090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834019091	active site
266834019092	phosphorylation site [posttranslational modification]
266834019093	intermolecular recognition site; other site
266834019094	dimerization interface [polypeptide binding]; other site
266834019095	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834019096	DNA binding residues [nucleotide binding]
266834019097	dimerization interface [polypeptide binding]; other site
266834019098	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
266834019099	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
266834019100	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
266834019101	Switch I; other site
266834019102	Switch II; other site
266834019103	septum formation inhibitor; Reviewed; Region: minC; PRK05177
266834019104	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
266834019105	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834019106	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834019107	active site
266834019108	catalytic tetrad [active]
266834019109	NAD synthetase; Reviewed; Region: nadE; PRK00876
266834019110	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
266834019111	homodimer interface [polypeptide binding]; other site
266834019112	NAD binding pocket [chemical binding]; other site
266834019113	ATP binding pocket [chemical binding]; other site
266834019114	Mg binding site [ion binding]; other site
266834019115	active-site loop [active]
266834019116	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
266834019117	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
266834019118	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922
266834019119	acyl-activating enzyme (AAE) consensus motif; other site
266834019120	putative AMP binding site [chemical binding]; other site
266834019121	putative active site [active]
266834019122	putative CoA binding site [chemical binding]; other site
266834019123	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
266834019124	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
266834019125	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
266834019126	active site
266834019127	dimer interface [polypeptide binding]; other site
266834019128	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
266834019129	Ligand Binding Site [chemical binding]; other site
266834019130	Molecular Tunnel; other site
266834019131	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
266834019132	dimer interface [polypeptide binding]; other site
266834019133	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
266834019134	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
266834019135	active site
266834019136	catalytic tetrad [active]
266834019137	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834019138	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834019139	dimer interface [polypeptide binding]; other site
266834019140	conserved gate region; other site
266834019141	putative PBP binding loops; other site
266834019142	ABC-ATPase subunit interface; other site
266834019143	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
266834019144	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834019145	dimer interface [polypeptide binding]; other site
266834019146	conserved gate region; other site
266834019147	putative PBP binding loops; other site
266834019148	ABC-ATPase subunit interface; other site
266834019149	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834019150	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834019151	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834019152	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834019153	Walker A/P-loop; other site
266834019154	ATP binding site [chemical binding]; other site
266834019155	Q-loop/lid; other site
266834019156	ABC transporter signature motif; other site
266834019157	Walker B; other site
266834019158	D-loop; other site
266834019159	H-loop/switch region; other site
266834019160	TOBE domain; Region: TOBE; pfam03459
266834019161	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
266834019162	classical (c) SDRs; Region: SDR_c; cd05233
266834019163	NAD(P) binding site [chemical binding]; other site
266834019164	active site
266834019165	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
266834019166	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
266834019167	putative NAD(P) binding site [chemical binding]; other site
266834019168	active site
266834019169	putative substrate binding site [chemical binding]; other site
266834019170	Transcriptional regulators [Transcription]; Region: FadR; COG2186
266834019171	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834019172	DNA-binding site [nucleotide binding]; DNA binding site
266834019173	FCD domain; Region: FCD; pfam07729
266834019174	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
266834019175	Transposase domain (DUF772); Region: DUF772; pfam05598
266834019176	putative aldolase; Validated; Region: PRK08130
266834019177	intersubunit interface [polypeptide binding]; other site
266834019178	active site
266834019179	Zn2+ binding site [ion binding]; other site
266834019180	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834019181	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834019182	DNA binding site [nucleotide binding]
266834019183	domain linker motif; other site
266834019184	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
266834019185	putative dimerization interface [polypeptide binding]; other site
266834019186	putative ligand binding site [chemical binding]; other site
266834019187	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
266834019188	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
266834019189	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
266834019190	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
266834019191	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834019192	Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308
266834019193	putative ligand binding site [chemical binding]; other site
266834019194	Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172
266834019195	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834019196	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834019197	TM-ABC transporter signature motif; other site
266834019198	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834019199	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834019200	Walker A/P-loop; other site
266834019201	ATP binding site [chemical binding]; other site
266834019202	Q-loop/lid; other site
266834019203	ABC transporter signature motif; other site
266834019204	Walker B; other site
266834019205	D-loop; other site
266834019206	H-loop/switch region; other site
266834019207	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834019208	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834019209	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834019210	DNA binding site [nucleotide binding]
266834019211	domain linker motif; other site
266834019212	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
266834019213	dimerization interface [polypeptide binding]; other site
266834019214	ligand binding site [chemical binding]; other site
266834019215	Uncharacterized conserved protein [Function unknown]; Region: COG3506
266834019216	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
266834019217	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
266834019218	ureidoglycolate hydrolase; Provisional; Region: PRK13395
266834019219	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
266834019220	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
266834019221	MOFRL family; Region: MOFRL; pfam05161
266834019222	tartronate semialdehyde reductase; Provisional; Region: PRK15059
266834019223	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
266834019224	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
266834019225	glyoxylate carboligase; Provisional; Region: PRK11269
266834019226	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
266834019227	PYR/PP interface [polypeptide binding]; other site
266834019228	dimer interface [polypeptide binding]; other site
266834019229	TPP binding site [chemical binding]; other site
266834019230	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
266834019231	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
266834019232	TPP-binding site [chemical binding]; other site
266834019233	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
266834019234	Transcriptional regulator [Transcription]; Region: IclR; COG1414
266834019235	Bacterial transcriptional regulator; Region: IclR; pfam01614
266834019236	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
266834019237	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834019238	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
266834019239	putative dimerization interface [polypeptide binding]; other site
266834019240	putative substrate binding pocket [chemical binding]; other site
266834019241	hypothetical protein; Provisional; Region: PRK11171
266834019242	Cupin domain; Region: Cupin_2; pfam07883
266834019243	Cupin domain; Region: Cupin_2; pfam07883
266834019244	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
266834019245	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
266834019246	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
266834019247	active site
266834019248	DNA binding site [nucleotide binding]
266834019249	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
266834019250	DNA binding site [nucleotide binding]
266834019251	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
266834019252	nucleotide binding site [chemical binding]; other site
266834019253	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
266834019254	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
266834019255	putative DNA binding site [nucleotide binding]; other site
266834019256	putative homodimer interface [polypeptide binding]; other site
266834019257	TPR repeat; Region: TPR_11; pfam13414
266834019258	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834019259	binding surface
266834019260	TPR motif; other site
266834019261	TPR repeat; Region: TPR_11; pfam13414
266834019262	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
266834019263	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
266834019264	putative catalytic site [active]
266834019265	putative phosphate binding site [ion binding]; other site
266834019266	active site
266834019267	metal binding site A [ion binding]; metal-binding site
266834019268	DNA binding site [nucleotide binding]
266834019269	putative AP binding site [nucleotide binding]; other site
266834019270	putative metal binding site B [ion binding]; other site
266834019271	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
266834019272	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
266834019273	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
266834019274	NADP binding site [chemical binding]; other site
266834019275	homodimer interface [polypeptide binding]; other site
266834019276	active site
266834019277	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
266834019278	Uncharacterized conserved protein [Function unknown]; Region: COG5654
266834019279	Uncharacterized conserved protein [Function unknown]; Region: COG5642
266834019280	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
266834019281	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
266834019282	putative metal binding site [ion binding]; other site
266834019283	Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546
266834019284	putative dimer interface [polypeptide binding]; other site
266834019285	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
266834019286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834019287	putative substrate translocation pore; other site
266834019288	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
266834019289	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
266834019290	HlyD family secretion protein; Region: HlyD_3; pfam13437
266834019291	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
266834019292	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
266834019293	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834019294	NAD(P) binding site [chemical binding]; other site
266834019295	active site
266834019296	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834019297	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834019298	DNA binding site [nucleotide binding]
266834019299	Predicted integral membrane protein [Function unknown]; Region: COG5616
266834019300	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
266834019301	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834019302	TPR motif; other site
266834019303	binding surface
266834019304	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834019305	binding surface
266834019306	TPR motif; other site
266834019307	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
266834019308	substrate binding site [chemical binding]; other site
266834019309	glycogen synthase; Provisional; Region: glgA; PRK00654
266834019310	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
266834019311	ADP-binding pocket [chemical binding]; other site
266834019312	homodimer interface [polypeptide binding]; other site
266834019313	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
266834019314	EamA-like transporter family; Region: EamA; pfam00892
266834019315	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
266834019316	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834019317	substrate binding pocket [chemical binding]; other site
266834019318	membrane-bound complex binding site; other site
266834019319	hinge residues; other site
266834019320	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834019321	cyclase homology domain; Region: CHD; cd07302
266834019322	nucleotidyl binding site; other site
266834019323	metal binding site [ion binding]; metal-binding site
266834019324	dimer interface [polypeptide binding]; other site
266834019325	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
266834019326	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
266834019327	DNA binding site [nucleotide binding]
266834019328	active site
266834019329	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
266834019330	active site
266834019331	DNA binding site [nucleotide binding]
266834019332	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
266834019333	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
266834019334	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
266834019335	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782
266834019336	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834019337	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
266834019338	putative ligand binding site [chemical binding]; other site
266834019339	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834019340	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834019341	Walker A/P-loop; other site
266834019342	ATP binding site [chemical binding]; other site
266834019343	Q-loop/lid; other site
266834019344	ABC transporter signature motif; other site
266834019345	Walker B; other site
266834019346	D-loop; other site
266834019347	H-loop/switch region; other site
266834019348	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834019349	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834019350	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834019351	TM-ABC transporter signature motif; other site
266834019352	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834019353	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834019354	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
266834019355	dimerization interface [polypeptide binding]; other site
266834019356	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
266834019357	EamA-like transporter family; Region: EamA; pfam00892
266834019358	EamA-like transporter family; Region: EamA; pfam00892
266834019359	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834019360	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
266834019361	DNA binding site [nucleotide binding]
266834019362	domain linker motif; other site
266834019363	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
266834019364	dimerization interface [polypeptide binding]; other site
266834019365	ligand binding site [chemical binding]; other site
266834019366	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834019367	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
266834019368	Walker A/P-loop; other site
266834019369	ATP binding site [chemical binding]; other site
266834019370	Q-loop/lid; other site
266834019371	ABC transporter signature motif; other site
266834019372	Walker B; other site
266834019373	D-loop; other site
266834019374	H-loop/switch region; other site
266834019375	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834019376	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834019377	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834019378	TM-ABC transporter signature motif; other site
266834019379	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
266834019380	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311
266834019381	putative ligand binding site [chemical binding]; other site
266834019382	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
266834019383	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834019384	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834019385	dimer interface [polypeptide binding]; other site
266834019386	phosphorylation site [posttranslational modification]
266834019387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834019388	ATP binding site [chemical binding]; other site
266834019389	Mg2+ binding site [ion binding]; other site
266834019390	G-X-G motif; other site
266834019391	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834019392	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834019393	active site
266834019394	phosphorylation site [posttranslational modification]
266834019395	intermolecular recognition site; other site
266834019396	dimerization interface [polypeptide binding]; other site
266834019397	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
266834019398	DNA binding site [nucleotide binding]
266834019399	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
266834019400	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
266834019401	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
266834019402	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
266834019403	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
266834019404	glutamine synthetase; Region: PLN02284
266834019405	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
266834019406	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
266834019407	Protein of unknown function (DUF2735); Region: DUF2735; pfam10931
266834019408	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
266834019409	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
266834019410	motif II; other site
266834019411	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
266834019412	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
266834019413	active site
266834019414	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
266834019415	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
266834019416	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
266834019417	gluconate 5-dehydrogenase; Provisional; Region: PRK06124
266834019418	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
266834019419	NAD(P) binding site [chemical binding]; other site
266834019420	active site
266834019421	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
266834019422	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
266834019423	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
266834019424	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
266834019425	substrate binding site [chemical binding]; other site
266834019426	oxyanion hole (OAH) forming residues; other site
266834019427	trimer interface [polypeptide binding]; other site
266834019428	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
266834019429	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
266834019430	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
266834019431	substrate binding pocket [chemical binding]; other site
266834019432	FAD binding site [chemical binding]; other site
266834019433	catalytic base [active]
266834019434	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
266834019435	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
266834019436	non-specific DNA binding site [nucleotide binding]; other site
266834019437	salt bridge; other site
266834019438	sequence-specific DNA binding site [nucleotide binding]; other site
266834019439	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
266834019440	Domain of unknown function (DUF955); Region: DUF955; pfam06114
266834019441	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
266834019442	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
266834019443	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
266834019444	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
266834019445	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
266834019446	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
266834019447	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
266834019448	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
266834019449	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
266834019450	carboxyltransferase (CT) interaction site; other site
266834019451	biotinylation site [posttranslational modification]; other site
266834019452	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
266834019453	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
266834019454	active site
266834019455	substrate binding site [chemical binding]; other site
266834019456	coenzyme B12 binding site [chemical binding]; other site
266834019457	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
266834019458	B12 binding site [chemical binding]; other site
266834019459	cobalt ligand [ion binding]; other site
266834019460	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
266834019461	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834019462	DNA-binding site [nucleotide binding]; DNA binding site
266834019463	UTRA domain; Region: UTRA; pfam07702
266834019464	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
266834019465	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625
266834019466	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626
266834019467	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627
266834019468	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
266834019469	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834019470	Walker A/P-loop; other site
266834019471	ATP binding site [chemical binding]; other site
266834019472	Q-loop/lid; other site
266834019473	ABC transporter signature motif; other site
266834019474	Walker B; other site
266834019475	D-loop; other site
266834019476	H-loop/switch region; other site
266834019477	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834019478	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
266834019479	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834019480	Walker A/P-loop; other site
266834019481	ATP binding site [chemical binding]; other site
266834019482	Q-loop/lid; other site
266834019483	ABC transporter signature motif; other site
266834019484	Walker B; other site
266834019485	D-loop; other site
266834019486	H-loop/switch region; other site
266834019487	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
266834019488	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
266834019489	trimer interface [polypeptide binding]; other site
266834019490	active site
266834019491	substrate binding site [chemical binding]; other site
266834019492	CoA binding site [chemical binding]; other site
266834019493	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
266834019494	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
266834019495	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
266834019496	dihydroxyacetone kinase; Provisional; Region: PRK14479
266834019497	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
266834019498	DAK2 domain; Region: Dak2; pfam02734
266834019499	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
266834019500	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
266834019501	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
266834019502	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
266834019503	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
266834019504	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
266834019505	Transcriptional regulators [Transcription]; Region: GntR; COG1802
266834019506	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
266834019507	DNA-binding site [nucleotide binding]; DNA binding site
266834019508	FCD domain; Region: FCD; pfam07729
266834019509	FecR protein; Region: FecR; pfam04773
266834019510	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834019511	TPR motif; other site
266834019512	TPR repeat; Region: TPR_11; pfam13414
266834019513	binding surface
266834019514	TPR repeat; Region: TPR_11; pfam13414
266834019515	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834019516	binding surface
266834019517	TPR motif; other site
266834019518	TPR repeat; Region: TPR_11; pfam13414
266834019519	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
266834019520	binding surface
266834019521	TPR motif; other site
266834019522	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
266834019523	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
266834019524	CHASE2 domain; Region: CHASE2; pfam05226
266834019525	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
266834019526	cyclase homology domain; Region: CHD; cd07302
266834019527	nucleotidyl binding site; other site
266834019528	metal binding site [ion binding]; metal-binding site
266834019529	dimer interface [polypeptide binding]; other site
266834019530	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
266834019531	Transposase; Region: DEDD_Tnp_IS110; pfam01548
266834019532	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
266834019533	DDE superfamily endonuclease; Region: DDE_3; pfam13358
266834019534	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
266834019535	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
266834019536	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
266834019537	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
266834019538	putative active site [active]
266834019539	putative NTP binding site [chemical binding]; other site
266834019540	putative nucleic acid binding site [nucleotide binding]; other site
266834019541	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
266834019542	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
266834019543	Helix-turn-helix domain; Region: HTH_28; pfam13518
266834019544	Homeodomain-like domain; Region: HTH_32; pfam13565
266834019545	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
266834019546	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
266834019547	Walker A/P-loop; other site
266834019548	ATP binding site [chemical binding]; other site
266834019549	Q-loop/lid; other site
266834019550	ABC transporter signature motif; other site
266834019551	Walker B; other site
266834019552	D-loop; other site
266834019553	H-loop/switch region; other site
266834019554	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
266834019555	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
266834019556	Walker A/P-loop; other site
266834019557	ATP binding site [chemical binding]; other site
266834019558	Q-loop/lid; other site
266834019559	ABC transporter signature motif; other site
266834019560	Walker B; other site
266834019561	D-loop; other site
266834019562	H-loop/switch region; other site
266834019563	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
266834019564	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834019565	TM-ABC transporter signature motif; other site
266834019566	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
266834019567	TM-ABC transporter signature motif; other site
266834019568	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
266834019569	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
266834019570	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
266834019571	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
266834019572	Walker A/P-loop; other site
266834019573	ATP binding site [chemical binding]; other site
266834019574	Q-loop/lid; other site
266834019575	ABC transporter signature motif; other site
266834019576	Walker B; other site
266834019577	D-loop; other site
266834019578	H-loop/switch region; other site
266834019579	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
266834019580	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
266834019581	substrate binding pocket [chemical binding]; other site
266834019582	membrane-bound complex binding site; other site
266834019583	hinge residues; other site
266834019584	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
266834019585	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834019586	dimer interface [polypeptide binding]; other site
266834019587	conserved gate region; other site
266834019588	putative PBP binding loops; other site
266834019589	ABC-ATPase subunit interface; other site
266834019590	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
266834019591	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
266834019592	active site
266834019593	non-prolyl cis peptide bond; other site
266834019594	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
266834019595	FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566
266834019596	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
266834019597	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
266834019598	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
266834019599	active site
266834019600	catalytic site [active]
266834019601	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975
266834019602	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
266834019603	tetramer interface [polypeptide binding]; other site
266834019604	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
266834019605	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
266834019606	heterodimer interface [polypeptide binding]; other site
266834019607	active site
266834019608	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
266834019609	heterodimer interface [polypeptide binding]; other site
266834019610	multimer interface [polypeptide binding]; other site
266834019611	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
266834019612	active site
266834019613	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
266834019614	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
266834019615	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
266834019616	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
266834019617	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834019618	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
266834019619	dimerization interface [polypeptide binding]; other site
266834019620	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
266834019621	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
266834019622	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
266834019623	dimer interface [polypeptide binding]; other site
266834019624	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
266834019625	active site
266834019626	Fe binding site [ion binding]; other site
266834019627	Transcriptional regulator [Transcription]; Region: LysR; COG0583
266834019628	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
266834019629	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
266834019630	putative dimerization interface [polypeptide binding]; other site
266834019631	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
266834019632	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
266834019633	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
266834019634	Moco binding site; other site
266834019635	metal coordination site [ion binding]; other site
266834019636	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
266834019637	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
266834019638	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
266834019639	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
266834019640	Bacterial transcriptional regulator; Region: IclR; pfam01614
266834019641	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
266834019642	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057
266834019643	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
266834019644	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
266834019645	dimer interface [polypeptide binding]; other site
266834019646	active site
266834019647	acylphosphatase; Provisional; Region: PRK14425
266834019648	RNA polymerase sigma factor; Provisional; Region: PRK11922
266834019649	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
266834019650	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
266834019651	DNA binding residues [nucleotide binding]
266834019652	Predicted outer membrane protein [Function unknown]; Region: COG3652
266834019653	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
266834019654	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
266834019655	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
266834019656	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
266834019657	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
266834019658	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
266834019659	Predicted membrane protein [Function unknown]; Region: COG2259
266834019660	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
266834019661	MerR family regulatory protein; Region: MerR; pfam00376
266834019662	DNA binding residues [nucleotide binding]
266834019663	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
266834019664	P-loop; other site
266834019665	Magnesium ion binding site [ion binding]; other site
266834019666	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
266834019667	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
266834019668	Magnesium ion binding site [ion binding]; other site
266834019669	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
266834019670	ParB-like nuclease domain; Region: ParBc; pfam02195
266834019671	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
266834019672	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
266834019673	Walker A/P-loop; other site
266834019674	ATP binding site [chemical binding]; other site
266834019675	Q-loop/lid; other site
266834019676	ABC transporter signature motif; other site
266834019677	Walker B; other site
266834019678	D-loop; other site
266834019679	H-loop/switch region; other site
266834019680	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
266834019681	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
266834019682	Walker A/P-loop; other site
266834019683	ATP binding site [chemical binding]; other site
266834019684	Q-loop/lid; other site
266834019685	ABC transporter signature motif; other site
266834019686	Walker B; other site
266834019687	D-loop; other site
266834019688	H-loop/switch region; other site
266834019689	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
266834019690	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
266834019691	TM-ABC transporter signature motif; other site
266834019692	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
266834019693	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834019694	TM-ABC transporter signature motif; other site
266834019695	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
266834019696	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
266834019697	putative ligand binding site [chemical binding]; other site
266834019698	Uncharacterized conserved protein [Function unknown]; Region: COG3791
266834019699	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
266834019700	putative hydrophobic ligand binding site [chemical binding]; other site
266834019701	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834019702	dimerization interface [polypeptide binding]; other site
266834019703	putative DNA binding site [nucleotide binding]; other site
266834019704	putative Zn2+ binding site [ion binding]; other site
266834019705	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
266834019706	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
266834019707	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834019708	dimer interface [polypeptide binding]; other site
266834019709	phosphorylation site [posttranslational modification]
266834019710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834019711	ATP binding site [chemical binding]; other site
266834019712	Mg2+ binding site [ion binding]; other site
266834019713	G-X-G motif; other site
266834019714	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
266834019715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834019716	active site
266834019717	phosphorylation site [posttranslational modification]
266834019718	intermolecular recognition site; other site
266834019719	dimerization interface [polypeptide binding]; other site
266834019720	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
266834019721	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834019722	active site
266834019723	phosphorylation site [posttranslational modification]
266834019724	intermolecular recognition site; other site
266834019725	dimerization interface [polypeptide binding]; other site
266834019726	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
266834019727	DNA binding residues [nucleotide binding]
266834019728	dimerization interface [polypeptide binding]; other site
266834019729	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
266834019730	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
266834019731	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
266834019732	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
266834019733	dimer interface [polypeptide binding]; other site
266834019734	phosphorylation site [posttranslational modification]
266834019735	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
266834019736	ATP binding site [chemical binding]; other site
266834019737	Mg2+ binding site [ion binding]; other site
266834019738	G-X-G motif; other site
266834019739	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
266834019740	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
266834019741	active site
266834019742	phosphorylation site [posttranslational modification]
266834019743	intermolecular recognition site; other site
266834019744	dimerization interface [polypeptide binding]; other site
266834019745	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
266834019746	Walker A motif; other site
266834019747	ATP binding site [chemical binding]; other site
266834019748	Walker B motif; other site
266834019749	arginine finger; other site
266834019750	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
266834019751	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
266834019752	ThiC-associated domain; Region: ThiC-associated; pfam13667
266834019753	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
266834019754	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
266834019755	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
266834019756	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
266834019757	ThiS interaction site; other site
266834019758	putative active site [active]
266834019759	tetramer interface [polypeptide binding]; other site
266834019760	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
266834019761	thiamine phosphate binding site [chemical binding]; other site
266834019762	active site
266834019763	pyrophosphate binding site [ion binding]; other site
266834019764	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
266834019765	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
266834019766	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
266834019767	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
266834019768	putative ligand binding site [chemical binding]; other site
266834019769	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
266834019770	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
266834019771	TM-ABC transporter signature motif; other site
266834019772	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
266834019773	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
266834019774	Walker A/P-loop; other site
266834019775	ATP binding site [chemical binding]; other site
266834019776	Q-loop/lid; other site
266834019777	ABC transporter signature motif; other site
266834019778	Walker B; other site
266834019779	D-loop; other site
266834019780	H-loop/switch region; other site
266834019781	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
266834019782	Phosphotransferase enzyme family; Region: APH; pfam01636
266834019783	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
266834019784	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
266834019785	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
266834019786	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
266834019787	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
266834019788	putative substrate translocation pore; other site
266834019789	Cupin; Region: Cupin_6; pfam12852
266834019790	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834019791	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834019792	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834019793	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
266834019794	Predicted transcriptional regulator [Transcription]; Region: COG3905
266834019795	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
266834019796	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
266834019797	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
266834019798	Walker A/P-loop; other site
266834019799	ATP binding site [chemical binding]; other site
266834019800	Q-loop/lid; other site
266834019801	ABC transporter signature motif; other site
266834019802	Walker B; other site
266834019803	D-loop; other site
266834019804	H-loop/switch region; other site
266834019805	TOBE domain; Region: TOBE_2; pfam08402
266834019806	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
266834019807	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
266834019808	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
266834019809	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834019810	dimer interface [polypeptide binding]; other site
266834019811	conserved gate region; other site
266834019812	putative PBP binding loops; other site
266834019813	ABC-ATPase subunit interface; other site
266834019814	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834019815	dimer interface [polypeptide binding]; other site
266834019816	conserved gate region; other site
266834019817	putative PBP binding loops; other site
266834019818	ABC-ATPase subunit interface; other site
266834019819	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
266834019820	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
266834019821	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
266834019822	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
266834019823	ligand binding site [chemical binding]; other site
266834019824	dimerization interface [polypeptide binding]; other site
266834019825	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
266834019826	Transposase; Region: DEDD_Tnp_IS110; pfam01548
266834019827	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
266834019828	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
266834019829	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
266834019830	NAD(P) binding pocket [chemical binding]; other site
266834019831	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
266834019832	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
266834019833	dimer interface [polypeptide binding]; other site
266834019834	active site
266834019835	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
266834019836	catalytic residues [active]
266834019837	substrate binding site [chemical binding]; other site
266834019838	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
266834019839	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
266834019840	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
266834019841	enoyl-CoA hydratase; Provisional; Region: PRK08140
266834019842	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
266834019843	substrate binding site [chemical binding]; other site
266834019844	oxyanion hole (OAH) forming residues; other site
266834019845	trimer interface [polypeptide binding]; other site
266834019846	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
266834019847	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
266834019848	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
266834019849	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
266834019850	substrate binding site [chemical binding]; other site
266834019851	dimer interface [polypeptide binding]; other site
266834019852	NADP binding site [chemical binding]; other site
266834019853	catalytic residues [active]
266834019854	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
266834019855	substrate binding site [chemical binding]; other site
266834019856	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
266834019857	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
266834019858	FAD binding pocket [chemical binding]; other site
266834019859	FAD binding motif [chemical binding]; other site
266834019860	phosphate binding motif [ion binding]; other site
266834019861	beta-alpha-beta structure motif; other site
266834019862	NAD(p) ribose binding residues [chemical binding]; other site
266834019863	NAD binding pocket [chemical binding]; other site
266834019864	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
266834019865	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
266834019866	catalytic loop [active]
266834019867	iron binding site [ion binding]; other site
266834019868	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
266834019869	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
266834019870	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
266834019871	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
266834019872	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
266834019873	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
266834019874	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
266834019875	Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327
266834019876	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
266834019877	putative DNA binding site [nucleotide binding]; other site
266834019878	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
266834019879	Protein of unknown function (DUF992); Region: DUF992; pfam06186
266834019880	alpha-galactosidase; Provisional; Region: PRK15076
266834019881	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
266834019882	NAD binding site [chemical binding]; other site
266834019883	sugar binding site [chemical binding]; other site
266834019884	divalent metal binding site [ion binding]; other site
266834019885	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
266834019886	dimer interface [polypeptide binding]; other site
266834019887	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
266834019888	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834019889	Walker A/P-loop; other site
266834019890	ATP binding site [chemical binding]; other site
266834019891	Q-loop/lid; other site
266834019892	ABC transporter signature motif; other site
266834019893	Walker B; other site
266834019894	D-loop; other site
266834019895	H-loop/switch region; other site
266834019896	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834019897	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
266834019898	Walker A/P-loop; other site
266834019899	ATP binding site [chemical binding]; other site
266834019900	Q-loop/lid; other site
266834019901	ABC transporter signature motif; other site
266834019902	Walker B; other site
266834019903	D-loop; other site
266834019904	H-loop/switch region; other site
266834019905	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
266834019906	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
266834019907	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834019908	dimer interface [polypeptide binding]; other site
266834019909	conserved gate region; other site
266834019910	putative PBP binding loops; other site
266834019911	ABC-ATPase subunit interface; other site
266834019912	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
266834019913	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
266834019914	dimer interface [polypeptide binding]; other site
266834019915	conserved gate region; other site
266834019916	putative PBP binding loops; other site
266834019917	ABC-ATPase subunit interface; other site
266834019918	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
266834019919	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
266834019920	alpha-galactosidase; Provisional; Region: PRK15076
266834019921	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
266834019922	NAD binding site [chemical binding]; other site
266834019923	sugar binding site [chemical binding]; other site
266834019924	divalent metal binding site [ion binding]; other site
266834019925	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
266834019926	dimer interface [polypeptide binding]; other site
266834019927	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
266834019928	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
266834019929	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
266834019930	Transcriptional regulators [Transcription]; Region: PurR; COG1609
266834019931	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
266834019932	putative dimerization interface [polypeptide binding]; other site
266834019933	putative ligand binding site [chemical binding]; other site
266834019934	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
266834019935	oligomeric interface; other site
266834019936	putative active site [active]
266834019937	homodimer interface [polypeptide binding]; other site