-- dump date 20140620_070350 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1286640000001 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286640000002 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286640000003 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1286640000004 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1286640000005 molybdopterin cofactor binding site; other site 1286640000006 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1286640000007 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286640000008 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1286640000009 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 1286640000010 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1286640000011 Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058 1286640000012 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1286640000013 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 1286640000014 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1286640000015 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1286640000016 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286640000017 catalytic residue [active] 1286640000018 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1286640000019 Sel1-like repeats; Region: SEL1; smart00671 1286640000020 Sel1-like repeats; Region: SEL1; smart00671 1286640000021 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 1286640000022 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1286640000023 G1 box; other site 1286640000024 putative GEF interaction site [polypeptide binding]; other site 1286640000025 GTP/Mg2+ binding site [chemical binding]; other site 1286640000026 Switch I region; other site 1286640000027 G2 box; other site 1286640000028 G3 box; other site 1286640000029 Switch II region; other site 1286640000030 G4 box; other site 1286640000031 G5 box; other site 1286640000032 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1286640000033 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1286640000034 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1286640000035 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1286640000036 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1286640000037 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640000038 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640000039 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1286640000040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1286640000041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1286640000042 active site 1286640000043 phosphorylation site [posttranslational modification] 1286640000044 intermolecular recognition site; other site 1286640000045 dimerization interface [polypeptide binding]; other site 1286640000046 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1286640000047 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1286640000048 selenophosphate synthetase; Provisional; Region: PRK00943 1286640000049 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1286640000050 dimerization interface [polypeptide binding]; other site 1286640000051 putative ATP binding site [chemical binding]; other site 1286640000052 NADH dehydrogenase subunit C; Validated; Region: PRK07735 1286640000053 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1286640000054 active site 1286640000055 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1286640000056 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1286640000057 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286640000058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640000059 Walker A/P-loop; other site 1286640000060 ATP binding site [chemical binding]; other site 1286640000061 Q-loop/lid; other site 1286640000062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286640000063 ABC transporter signature motif; other site 1286640000064 Walker B; other site 1286640000065 D-loop; other site 1286640000066 ABC transporter; Region: ABC_tran_2; pfam12848 1286640000067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286640000068 transcriptional regulator; Provisional; Region: PRK10632 1286640000069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640000070 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1286640000071 putative effector binding pocket; other site 1286640000072 putative dimerization interface [polypeptide binding]; other site 1286640000073 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 1286640000074 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286640000075 putative NAD(P) binding site [chemical binding]; other site 1286640000076 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1286640000077 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 1286640000078 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1286640000079 active site 1286640000080 zinc binding site [ion binding]; other site 1286640000081 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640000082 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1286640000083 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1286640000084 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1286640000085 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1286640000086 metal binding site [ion binding]; metal-binding site 1286640000087 substrate binding pocket [chemical binding]; other site 1286640000088 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1286640000089 dimerization interface [polypeptide binding]; other site 1286640000090 putative active cleft [active] 1286640000091 aldose dehydrogenase; Validated; Region: PRK06398 1286640000092 classical (c) SDRs; Region: SDR_c; cd05233 1286640000093 NAD(P) binding site [chemical binding]; other site 1286640000094 active site 1286640000095 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1286640000096 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640000097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640000098 DNA-binding site [nucleotide binding]; DNA binding site 1286640000099 FCD domain; Region: FCD; pfam07729 1286640000100 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640000101 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640000102 DNA-binding site [nucleotide binding]; DNA binding site 1286640000103 FCD domain; Region: FCD; pfam07729 1286640000104 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1286640000105 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1286640000106 active site pocket [active] 1286640000107 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640000108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640000109 DNA-binding site [nucleotide binding]; DNA binding site 1286640000110 FCD domain; Region: FCD; pfam07729 1286640000111 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640000112 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1286640000113 putative ligand binding site [chemical binding]; other site 1286640000114 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640000115 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640000116 TM-ABC transporter signature motif; other site 1286640000117 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1286640000118 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640000119 Walker A/P-loop; other site 1286640000120 ATP binding site [chemical binding]; other site 1286640000121 Q-loop/lid; other site 1286640000122 ABC transporter signature motif; other site 1286640000123 Walker B; other site 1286640000124 D-loop; other site 1286640000125 H-loop/switch region; other site 1286640000126 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1286640000127 classical (c) SDRs; Region: SDR_c; cd05233 1286640000128 NAD(P) binding site [chemical binding]; other site 1286640000129 active site 1286640000130 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1286640000131 active site 1286640000132 catalytic residues [active] 1286640000133 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640000134 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640000135 DNA binding site [nucleotide binding] 1286640000136 domain linker motif; other site 1286640000137 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1286640000138 putative dimerization interface [polypeptide binding]; other site 1286640000139 putative ligand binding site [chemical binding]; other site 1286640000140 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640000141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000142 dimer interface [polypeptide binding]; other site 1286640000143 conserved gate region; other site 1286640000144 putative PBP binding loops; other site 1286640000145 ABC-ATPase subunit interface; other site 1286640000146 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640000147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000148 dimer interface [polypeptide binding]; other site 1286640000149 conserved gate region; other site 1286640000150 putative PBP binding loops; other site 1286640000151 ABC-ATPase subunit interface; other site 1286640000152 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286640000153 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640000154 substrate binding pocket [chemical binding]; other site 1286640000155 membrane-bound complex binding site; other site 1286640000156 hinge residues; other site 1286640000157 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286640000158 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286640000159 Walker A/P-loop; other site 1286640000160 ATP binding site [chemical binding]; other site 1286640000161 Q-loop/lid; other site 1286640000162 ABC transporter signature motif; other site 1286640000163 Walker B; other site 1286640000164 D-loop; other site 1286640000165 H-loop/switch region; other site 1286640000166 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1286640000167 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1286640000168 putative ligand binding site [chemical binding]; other site 1286640000169 NAD binding site [chemical binding]; other site 1286640000170 catalytic site [active] 1286640000171 EthD domain; Region: EthD; cl17553 1286640000172 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1286640000173 homotrimer interaction site [polypeptide binding]; other site 1286640000174 putative active site [active] 1286640000175 BA14K-like protein; Region: BA14K; pfam07886 1286640000176 BA14K-like protein; Region: BA14K; pfam07886 1286640000177 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1286640000178 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1286640000179 homodimer interface [polypeptide binding]; other site 1286640000180 substrate-cofactor binding pocket; other site 1286640000181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640000182 catalytic residue [active] 1286640000183 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1286640000184 homodimer interface [polypeptide binding]; other site 1286640000185 homotetramer interface [polypeptide binding]; other site 1286640000186 active site pocket [active] 1286640000187 cleavage site 1286640000188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640000189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640000190 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1286640000191 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1286640000192 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1286640000193 active site 1286640000194 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1286640000195 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640000196 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640000197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000198 dimer interface [polypeptide binding]; other site 1286640000199 conserved gate region; other site 1286640000200 putative PBP binding loops; other site 1286640000201 ABC-ATPase subunit interface; other site 1286640000202 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286640000203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000204 dimer interface [polypeptide binding]; other site 1286640000205 conserved gate region; other site 1286640000206 putative PBP binding loops; other site 1286640000207 ABC-ATPase subunit interface; other site 1286640000208 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286640000209 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640000210 Walker A/P-loop; other site 1286640000211 ATP binding site [chemical binding]; other site 1286640000212 Q-loop/lid; other site 1286640000213 ABC transporter signature motif; other site 1286640000214 Walker B; other site 1286640000215 D-loop; other site 1286640000216 H-loop/switch region; other site 1286640000217 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640000218 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1286640000219 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640000220 Walker A/P-loop; other site 1286640000221 ATP binding site [chemical binding]; other site 1286640000222 Q-loop/lid; other site 1286640000223 ABC transporter signature motif; other site 1286640000224 Walker B; other site 1286640000225 D-loop; other site 1286640000226 H-loop/switch region; other site 1286640000227 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640000228 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1286640000229 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1286640000230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640000231 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1286640000232 putative active site [active] 1286640000233 heme pocket [chemical binding]; other site 1286640000234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640000235 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1286640000236 putative active site [active] 1286640000237 heme pocket [chemical binding]; other site 1286640000238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640000239 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1286640000240 putative active site [active] 1286640000241 heme pocket [chemical binding]; other site 1286640000242 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640000243 putative active site [active] 1286640000244 heme pocket [chemical binding]; other site 1286640000245 PAS domain S-box; Region: sensory_box; TIGR00229 1286640000246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640000247 putative active site [active] 1286640000248 heme pocket [chemical binding]; other site 1286640000249 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1286640000250 HWE histidine kinase; Region: HWE_HK; pfam07536 1286640000251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640000252 active site 1286640000253 phosphorylation site [posttranslational modification] 1286640000254 intermolecular recognition site; other site 1286640000255 dimerization interface [polypeptide binding]; other site 1286640000256 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1286640000257 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1286640000258 HSP70 interaction site [polypeptide binding]; other site 1286640000259 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1286640000260 substrate binding site [polypeptide binding]; other site 1286640000261 dimer interface [polypeptide binding]; other site 1286640000262 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1286640000263 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286640000264 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 1286640000265 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1286640000266 ring oligomerisation interface [polypeptide binding]; other site 1286640000267 ATP/Mg binding site [chemical binding]; other site 1286640000268 stacking interactions; other site 1286640000269 hinge regions; other site 1286640000270 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1286640000271 oligomerisation interface [polypeptide binding]; other site 1286640000272 mobile loop; other site 1286640000273 roof hairpin; other site 1286640000274 Cold shock proteins [Transcription]; Region: CspC; COG1278 1286640000275 RNA binding site [nucleotide binding]; other site 1286640000276 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1286640000277 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1286640000278 putative di-iron ligands [ion binding]; other site 1286640000279 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1286640000280 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1286640000281 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 1286640000282 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286640000283 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640000284 metal binding site [ion binding]; metal-binding site 1286640000285 active site 1286640000286 I-site; other site 1286640000287 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640000288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3865 1286640000289 active site 1286640000290 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286640000291 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 1286640000292 active site 1286640000293 catalytic triad [active] 1286640000294 RNA polymerase sigma factor; Provisional; Region: PRK12547 1286640000295 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286640000296 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640000297 DNA binding residues [nucleotide binding] 1286640000298 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1286640000299 transcription elongation factor regulatory protein; Validated; Region: PRK06342 1286640000300 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1286640000301 malonyl-CoA synthase; Validated; Region: PRK07514 1286640000302 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 1286640000303 acyl-activating enzyme (AAE) consensus motif; other site 1286640000304 active site 1286640000305 AMP binding site [chemical binding]; other site 1286640000306 CoA binding site [chemical binding]; other site 1286640000307 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 1286640000308 DctM-like transporters; Region: DctM; pfam06808 1286640000309 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1286640000310 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1286640000311 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1286640000312 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1286640000313 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640000314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640000315 DNA-binding site [nucleotide binding]; DNA binding site 1286640000316 FCD domain; Region: FCD; pfam07729 1286640000317 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1286640000318 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1286640000319 BON domain; Region: BON; pfam04972 1286640000320 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1286640000321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640000322 binding surface 1286640000323 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1286640000324 TPR motif; other site 1286640000325 hypothetical protein; Provisional; Region: PRK08317 1286640000326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640000327 S-adenosylmethionine binding site [chemical binding]; other site 1286640000328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640000329 S-adenosylmethionine binding site [chemical binding]; other site 1286640000330 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1286640000331 Uncharacterized conserved protein [Function unknown]; Region: COG2326 1286640000332 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1286640000333 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286640000334 GYD domain; Region: GYD; pfam08734 1286640000335 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286640000336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640000337 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1286640000338 dimerization interface [polypeptide binding]; other site 1286640000339 substrate binding pocket [chemical binding]; other site 1286640000340 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1286640000341 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286640000342 DNA-binding site [nucleotide binding]; DNA binding site 1286640000343 RNA-binding motif; other site 1286640000344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640000345 putative substrate translocation pore; other site 1286640000346 short chain dehydrogenase; Provisional; Region: PRK06701 1286640000347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640000348 NAD(P) binding site [chemical binding]; other site 1286640000349 active site 1286640000350 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640000351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640000352 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1286640000353 putative hydrophobic ligand binding site [chemical binding]; other site 1286640000354 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640000355 dimerization interface [polypeptide binding]; other site 1286640000356 putative DNA binding site [nucleotide binding]; other site 1286640000357 putative Zn2+ binding site [ion binding]; other site 1286640000358 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1286640000359 Strictosidine synthase; Region: Str_synth; pfam03088 1286640000360 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640000361 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640000362 TM-ABC transporter signature motif; other site 1286640000363 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640000364 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640000365 TM-ABC transporter signature motif; other site 1286640000366 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640000367 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640000368 Walker A/P-loop; other site 1286640000369 ATP binding site [chemical binding]; other site 1286640000370 Q-loop/lid; other site 1286640000371 ABC transporter signature motif; other site 1286640000372 Walker B; other site 1286640000373 D-loop; other site 1286640000374 H-loop/switch region; other site 1286640000375 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640000376 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640000377 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 1286640000378 putative ligand binding site [chemical binding]; other site 1286640000379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1286640000380 Histidine kinase; Region: HisKA_3; pfam07730 1286640000381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640000382 ATP binding site [chemical binding]; other site 1286640000383 Mg2+ binding site [ion binding]; other site 1286640000384 G-X-G motif; other site 1286640000385 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640000386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640000387 active site 1286640000388 phosphorylation site [posttranslational modification] 1286640000389 intermolecular recognition site; other site 1286640000390 dimerization interface [polypeptide binding]; other site 1286640000391 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1286640000392 DNA binding residues [nucleotide binding] 1286640000393 Uncharacterized conserved protein [Function unknown]; Region: COG5397 1286640000394 5-keto 4-deoxyuronate isomerase [Carbohydrate transport and metabolism]; Region: KduI; COG3717 1286640000395 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1286640000396 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640000397 Walker A/P-loop; other site 1286640000398 ATP binding site [chemical binding]; other site 1286640000399 Q-loop/lid; other site 1286640000400 ABC transporter signature motif; other site 1286640000401 Walker B; other site 1286640000402 D-loop; other site 1286640000403 H-loop/switch region; other site 1286640000404 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640000405 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640000406 TM-ABC transporter signature motif; other site 1286640000407 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1286640000408 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286640000409 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286640000410 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 1286640000411 NAD(P) binding site [chemical binding]; other site 1286640000412 catalytic residues [active] 1286640000413 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640000414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640000415 DNA-binding site [nucleotide binding]; DNA binding site 1286640000416 FCD domain; Region: FCD; pfam07729 1286640000417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640000418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640000419 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1286640000420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640000421 putative substrate translocation pore; other site 1286640000422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640000423 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1286640000424 glutamate dehydrogenase; Provisional; Region: PRK09414 1286640000425 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1286640000426 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1286640000427 NAD(P) binding site [chemical binding]; other site 1286640000428 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1286640000429 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1286640000430 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 1286640000431 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1286640000432 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1286640000433 active site 1286640000434 homotetramer interface [polypeptide binding]; other site 1286640000435 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 1286640000436 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1286640000437 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286640000438 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640000439 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1286640000440 putative NAD(P) binding site [chemical binding]; other site 1286640000441 active site 1286640000442 putative substrate binding site [chemical binding]; other site 1286640000443 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286640000444 FAD binding domain; Region: FAD_binding_4; pfam01565 1286640000445 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640000446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640000447 DNA-binding site [nucleotide binding]; DNA binding site 1286640000448 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286640000449 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 1286640000450 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1286640000451 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1286640000452 DctM-like transporters; Region: DctM; pfam06808 1286640000453 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1286640000454 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1286640000455 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1286640000456 Uncharacterized conserved protein [Function unknown]; Region: COG5482 1286640000457 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 1286640000458 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1286640000459 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1286640000460 active site 1286640000461 catalytic site [active] 1286640000462 substrate binding site [chemical binding]; other site 1286640000463 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 1286640000464 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1286640000465 FMN binding site [chemical binding]; other site 1286640000466 active site 1286640000467 homodimer interface [polypeptide binding]; other site 1286640000468 putative catalytic residue [active] 1286640000469 4Fe-4S cluster binding site [ion binding]; other site 1286640000470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286640000471 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1286640000472 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1286640000473 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286640000474 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1286640000475 tetramerization interface [polypeptide binding]; other site 1286640000476 NAD(P) binding site [chemical binding]; other site 1286640000477 catalytic residues [active] 1286640000478 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1286640000479 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1286640000480 active site 1286640000481 NAD binding site [chemical binding]; other site 1286640000482 metal binding site [ion binding]; metal-binding site 1286640000483 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1286640000484 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640000485 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640000486 DNA-binding site [nucleotide binding]; DNA binding site 1286640000487 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286640000488 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640000489 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640000490 Walker A/P-loop; other site 1286640000491 ATP binding site [chemical binding]; other site 1286640000492 Q-loop/lid; other site 1286640000493 ABC transporter signature motif; other site 1286640000494 Walker B; other site 1286640000495 D-loop; other site 1286640000496 H-loop/switch region; other site 1286640000497 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640000498 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640000499 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640000500 TM-ABC transporter signature motif; other site 1286640000501 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640000502 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 1286640000503 putative ligand binding site [chemical binding]; other site 1286640000504 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1286640000505 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1286640000506 conserved cys residue [active] 1286640000507 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 1286640000508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640000509 S-adenosylmethionine binding site [chemical binding]; other site 1286640000510 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 1286640000511 Methylamine utilisation protein MauE; Region: MauE; pfam07291 1286640000512 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 1286640000513 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1286640000514 DNA binding residues [nucleotide binding] 1286640000515 dimer interface [polypeptide binding]; other site 1286640000516 mercury binding site [ion binding]; other site 1286640000517 Protein of unknown function (DUF433); Region: DUF433; cl01030 1286640000518 TIGR02588 family protein; Region: TIGR02588 1286640000519 putative integral membrane protein TIGR02587; Region: TIGR02587 1286640000520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640000521 active site 1286640000522 phosphorylation site [posttranslational modification] 1286640000523 intermolecular recognition site; other site 1286640000524 dimerization interface [polypeptide binding]; other site 1286640000525 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286640000526 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640000527 Walker A/P-loop; other site 1286640000528 ATP binding site [chemical binding]; other site 1286640000529 Q-loop/lid; other site 1286640000530 ABC transporter signature motif; other site 1286640000531 Walker B; other site 1286640000532 D-loop; other site 1286640000533 H-loop/switch region; other site 1286640000534 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1286640000535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640000536 Walker A/P-loop; other site 1286640000537 ATP binding site [chemical binding]; other site 1286640000538 Q-loop/lid; other site 1286640000539 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286640000540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000541 dimer interface [polypeptide binding]; other site 1286640000542 conserved gate region; other site 1286640000543 ABC-ATPase subunit interface; other site 1286640000544 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640000545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000546 conserved gate region; other site 1286640000547 dimer interface [polypeptide binding]; other site 1286640000548 putative PBP binding loops; other site 1286640000549 ABC-ATPase subunit interface; other site 1286640000550 Cupin domain; Region: Cupin_2; cl17218 1286640000551 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640000552 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1286640000553 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286640000554 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640000555 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1286640000556 dimerization interface [polypeptide binding]; other site 1286640000557 substrate binding pocket [chemical binding]; other site 1286640000558 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1286640000559 active sites [active] 1286640000560 tetramer interface [polypeptide binding]; other site 1286640000561 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1286640000562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640000563 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1286640000564 putative dimerization interface [polypeptide binding]; other site 1286640000565 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286640000566 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640000567 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1286640000568 putative effector binding pocket; other site 1286640000569 putative dimerization interface [polypeptide binding]; other site 1286640000570 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 1286640000571 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1286640000572 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1286640000573 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1286640000574 Cupin; Region: Cupin_6; pfam12852 1286640000575 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286640000576 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640000577 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640000578 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1286640000579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640000580 NAD(P) binding site [chemical binding]; other site 1286640000581 active site 1286640000582 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1286640000583 Uncharacterized conserved protein [Function unknown]; Region: COG5470 1286640000584 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1286640000585 short chain dehydrogenase; Provisional; Region: PRK06180 1286640000586 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1286640000587 NADP binding site [chemical binding]; other site 1286640000588 active site 1286640000589 steroid binding site; other site 1286640000590 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1286640000591 classical (c) SDRs; Region: SDR_c; cd05233 1286640000592 NAD(P) binding site [chemical binding]; other site 1286640000593 active site 1286640000594 Predicted membrane protein [Function unknown]; Region: COG2259 1286640000595 DoxX; Region: DoxX; pfam07681 1286640000596 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1286640000597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640000598 NAD(P) binding site [chemical binding]; other site 1286640000599 active site 1286640000600 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1286640000601 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640000602 classical (c) SDRs; Region: SDR_c; cd05233 1286640000603 NAD(P) binding site [chemical binding]; other site 1286640000604 active site 1286640000605 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1286640000606 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286640000607 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1286640000608 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1286640000609 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1286640000610 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640000611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640000612 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1286640000613 substrate binding pocket [chemical binding]; other site 1286640000614 dimerization interface [polypeptide binding]; other site 1286640000615 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1286640000616 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1286640000617 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1286640000618 Pirin-related protein [General function prediction only]; Region: COG1741 1286640000619 Pirin; Region: Pirin; pfam02678 1286640000620 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1286640000621 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640000622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640000623 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1286640000624 dimerization interface [polypeptide binding]; other site 1286640000625 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640000626 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640000627 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1286640000628 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1286640000629 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1286640000630 Homeodomain-like domain; Region: HTH_23; cl17451 1286640000631 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1286640000632 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1286640000633 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640000634 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640000635 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640000636 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640000637 putative effector binding pocket; other site 1286640000638 dimerization interface [polypeptide binding]; other site 1286640000639 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1286640000640 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640000641 Zn binding site [ion binding]; other site 1286640000642 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1286640000643 Zn binding site [ion binding]; other site 1286640000644 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1286640000645 Isochorismatase family; Region: Isochorismatase; pfam00857 1286640000646 catalytic triad [active] 1286640000647 dimer interface [polypeptide binding]; other site 1286640000648 conserved cis-peptide bond; other site 1286640000649 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 1286640000650 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1286640000651 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1286640000652 active site 1286640000653 Predicted membrane protein [Function unknown]; Region: COG2259 1286640000654 Transmembrane secretion effector; Region: MFS_3; pfam05977 1286640000655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640000656 putative substrate translocation pore; other site 1286640000657 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1286640000658 MULE transposase domain; Region: MULE; pfam10551 1286640000659 histidinol-phosphate aminotransferase; Provisional; Region: PRK05166 1286640000660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640000661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640000662 homodimer interface [polypeptide binding]; other site 1286640000663 catalytic residue [active] 1286640000664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640000665 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1286640000666 NAD(P) binding site [chemical binding]; other site 1286640000667 active site 1286640000668 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286640000669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640000670 Walker A/P-loop; other site 1286640000671 ATP binding site [chemical binding]; other site 1286640000672 Q-loop/lid; other site 1286640000673 ABC transporter signature motif; other site 1286640000674 Walker B; other site 1286640000675 D-loop; other site 1286640000676 H-loop/switch region; other site 1286640000677 TOBE domain; Region: TOBE_2; pfam08402 1286640000678 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1286640000679 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286640000680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000681 dimer interface [polypeptide binding]; other site 1286640000682 conserved gate region; other site 1286640000683 putative PBP binding loops; other site 1286640000684 ABC-ATPase subunit interface; other site 1286640000685 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640000686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000687 dimer interface [polypeptide binding]; other site 1286640000688 conserved gate region; other site 1286640000689 putative PBP binding loops; other site 1286640000690 ABC-ATPase subunit interface; other site 1286640000691 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1286640000692 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1286640000693 NAD binding site [chemical binding]; other site 1286640000694 dimerization interface [polypeptide binding]; other site 1286640000695 product binding site; other site 1286640000696 substrate binding site [chemical binding]; other site 1286640000697 zinc binding site [ion binding]; other site 1286640000698 catalytic residues [active] 1286640000699 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286640000700 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286640000701 NAD(P) binding site [chemical binding]; other site 1286640000702 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1286640000703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640000704 DNA-binding site [nucleotide binding]; DNA binding site 1286640000705 UTRA domain; Region: UTRA; pfam07702 1286640000706 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1286640000707 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1286640000708 phosphate binding site [ion binding]; other site 1286640000709 Uncharacterized conserved protein [Function unknown]; Region: COG5588 1286640000710 conserved hypothetical protein; Region: TIGR02118 1286640000711 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1286640000712 ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793 1286640000713 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1286640000714 active site 1286640000715 DNA binding site [nucleotide binding] 1286640000716 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1286640000717 DNA binding site [nucleotide binding] 1286640000718 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1286640000719 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1286640000720 Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]; Region: COG3285 1286640000721 nucleotide binding site [chemical binding]; other site 1286640000722 GXWXG protein; Region: GXWXG; pfam14231 1286640000723 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1286640000724 Protein of unknown function (DUF768); Region: DUF768; pfam05589 1286640000725 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1286640000726 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1286640000727 active site 1286640000728 DNA binding site [nucleotide binding] 1286640000729 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1286640000730 DNA binding site [nucleotide binding] 1286640000731 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 1286640000732 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1286640000733 putative DNA binding site [nucleotide binding]; other site 1286640000734 putative homodimer interface [polypeptide binding]; other site 1286640000735 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1286640000736 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1286640000737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640000738 PAS domain; Region: PAS_9; pfam13426 1286640000739 putative active site [active] 1286640000740 heme pocket [chemical binding]; other site 1286640000741 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 1286640000742 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1286640000743 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 1286640000744 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 1286640000745 HTH-like domain; Region: HTH_21; pfam13276 1286640000746 Integrase core domain; Region: rve; pfam00665 1286640000747 Integrase core domain; Region: rve_3; pfam13683 1286640000748 Transposase; Region: HTH_Tnp_1; cl17663 1286640000749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286640000750 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1286640000751 prevent-host-death family protein; Region: phd_fam; TIGR01552 1286640000752 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1286640000753 oligomeric interface; other site 1286640000754 putative active site [active] 1286640000755 homodimer interface [polypeptide binding]; other site 1286640000756 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 1286640000757 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1286640000758 MULE transposase domain; Region: MULE; pfam10551 1286640000759 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 1286640000760 putative heme binding site [chemical binding]; other site 1286640000761 putative substrate binding site [chemical binding]; other site 1286640000762 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640000763 cyclase homology domain; Region: CHD; cd07302 1286640000764 nucleotidyl binding site; other site 1286640000765 metal binding site [ion binding]; metal-binding site 1286640000766 dimer interface [polypeptide binding]; other site 1286640000767 Predicted ATPase [General function prediction only]; Region: COG3899 1286640000768 AAA ATPase domain; Region: AAA_16; pfam13191 1286640000769 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640000770 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1286640000771 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640000772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286640000773 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1286640000774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000775 dimer interface [polypeptide binding]; other site 1286640000776 conserved gate region; other site 1286640000777 putative PBP binding loops; other site 1286640000778 ABC-ATPase subunit interface; other site 1286640000779 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1286640000780 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640000781 Walker A/P-loop; other site 1286640000782 ATP binding site [chemical binding]; other site 1286640000783 Q-loop/lid; other site 1286640000784 ABC transporter signature motif; other site 1286640000785 Walker B; other site 1286640000786 D-loop; other site 1286640000787 H-loop/switch region; other site 1286640000788 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640000789 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640000790 Walker A/P-loop; other site 1286640000791 ATP binding site [chemical binding]; other site 1286640000792 Q-loop/lid; other site 1286640000793 ABC transporter signature motif; other site 1286640000794 Walker B; other site 1286640000795 D-loop; other site 1286640000796 H-loop/switch region; other site 1286640000797 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1286640000798 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 1286640000799 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1286640000800 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1286640000801 Transposase domain (DUF772); Region: DUF772; pfam05598 1286640000802 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1286640000803 formate dehydrogenase; Provisional; Region: PRK07574 1286640000804 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1286640000805 dimerization interface [polypeptide binding]; other site 1286640000806 ligand binding site [chemical binding]; other site 1286640000807 NAD binding site [chemical binding]; other site 1286640000808 catalytic site [active] 1286640000809 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1286640000810 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1286640000811 active site 1286640000812 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1286640000813 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1286640000814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640000815 catalytic residue [active] 1286640000816 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1286640000817 ornithine cyclodeaminase; Validated; Region: PRK06823 1286640000818 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286640000819 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286640000820 Walker A/P-loop; other site 1286640000821 ATP binding site [chemical binding]; other site 1286640000822 Q-loop/lid; other site 1286640000823 ABC transporter signature motif; other site 1286640000824 Walker B; other site 1286640000825 D-loop; other site 1286640000826 H-loop/switch region; other site 1286640000827 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640000828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000829 dimer interface [polypeptide binding]; other site 1286640000830 conserved gate region; other site 1286640000831 putative PBP binding loops; other site 1286640000832 ABC-ATPase subunit interface; other site 1286640000833 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640000834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000835 dimer interface [polypeptide binding]; other site 1286640000836 conserved gate region; other site 1286640000837 putative PBP binding loops; other site 1286640000838 ABC-ATPase subunit interface; other site 1286640000839 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286640000840 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640000841 substrate binding pocket [chemical binding]; other site 1286640000842 membrane-bound complex binding site; other site 1286640000843 hinge residues; other site 1286640000844 HTH domain; Region: HTH_22; pfam13309 1286640000845 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640000846 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1286640000847 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286640000848 dimerization interface [polypeptide binding]; other site 1286640000849 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 1286640000850 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286640000851 Zn2+ binding site [ion binding]; other site 1286640000852 Mg2+ binding site [ion binding]; other site 1286640000853 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640000854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000855 dimer interface [polypeptide binding]; other site 1286640000856 conserved gate region; other site 1286640000857 putative PBP binding loops; other site 1286640000858 ABC-ATPase subunit interface; other site 1286640000859 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640000860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000861 dimer interface [polypeptide binding]; other site 1286640000862 conserved gate region; other site 1286640000863 putative PBP binding loops; other site 1286640000864 ABC-ATPase subunit interface; other site 1286640000865 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286640000866 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640000867 substrate binding pocket [chemical binding]; other site 1286640000868 membrane-bound complex binding site; other site 1286640000869 hinge residues; other site 1286640000870 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286640000871 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286640000872 Walker A/P-loop; other site 1286640000873 ATP binding site [chemical binding]; other site 1286640000874 Q-loop/lid; other site 1286640000875 ABC transporter signature motif; other site 1286640000876 Walker B; other site 1286640000877 D-loop; other site 1286640000878 H-loop/switch region; other site 1286640000879 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1286640000880 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1286640000881 putative ligand binding site [chemical binding]; other site 1286640000882 NAD binding site [chemical binding]; other site 1286640000883 catalytic site [active] 1286640000884 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1286640000885 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1286640000886 putative NAD(P) binding site [chemical binding]; other site 1286640000887 catalytic Zn binding site [ion binding]; other site 1286640000888 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 1286640000889 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1286640000890 NADP binding site [chemical binding]; other site 1286640000891 homodimer interface [polypeptide binding]; other site 1286640000892 active site 1286640000893 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1286640000894 AAA domain; Region: AAA_33; pfam13671 1286640000895 ATP-binding site [chemical binding]; other site 1286640000896 Gluconate-6-phosphate binding site [chemical binding]; other site 1286640000897 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1286640000898 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286640000899 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286640000900 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286640000901 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1286640000902 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286640000903 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286640000904 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286640000905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000906 dimer interface [polypeptide binding]; other site 1286640000907 conserved gate region; other site 1286640000908 putative PBP binding loops; other site 1286640000909 ABC-ATPase subunit interface; other site 1286640000910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000911 dimer interface [polypeptide binding]; other site 1286640000912 conserved gate region; other site 1286640000913 putative PBP binding loops; other site 1286640000914 ABC-ATPase subunit interface; other site 1286640000915 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286640000916 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1286640000917 Walker A/P-loop; other site 1286640000918 ATP binding site [chemical binding]; other site 1286640000919 Q-loop/lid; other site 1286640000920 ABC transporter signature motif; other site 1286640000921 Walker B; other site 1286640000922 D-loop; other site 1286640000923 H-loop/switch region; other site 1286640000924 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286640000925 catalytic core [active] 1286640000926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640000927 S-adenosylmethionine binding site [chemical binding]; other site 1286640000928 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1286640000929 SnoaL-like domain; Region: SnoaL_3; pfam13474 1286640000930 PRC-barrel domain; Region: PRC; pfam05239 1286640000931 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1286640000932 putative active site [active] 1286640000933 homotetrameric interface [polypeptide binding]; other site 1286640000934 metal binding site [ion binding]; metal-binding site 1286640000935 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1286640000936 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 1286640000937 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286640000938 active site 1286640000939 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286640000940 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640000941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640000942 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1286640000943 putative effector binding pocket; other site 1286640000944 putative dimerization interface [polypeptide binding]; other site 1286640000945 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1286640000946 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1286640000947 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1286640000948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4334 1286640000949 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640000950 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640000951 active site 1286640000952 catalytic tetrad [active] 1286640000953 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1286640000954 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1286640000955 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1286640000956 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286640000957 CoA binding site [chemical binding]; other site 1286640000958 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640000959 cyclase homology domain; Region: CHD; cd07302 1286640000960 nucleotidyl binding site; other site 1286640000961 metal binding site [ion binding]; metal-binding site 1286640000962 dimer interface [polypeptide binding]; other site 1286640000963 Predicted integral membrane protein [Function unknown]; Region: COG5616 1286640000964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640000965 TPR motif; other site 1286640000966 binding surface 1286640000967 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1286640000968 Uncharacterized conserved protein [Function unknown]; Region: COG3246 1286640000969 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1286640000970 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1286640000971 dimerization interface [polypeptide binding]; other site 1286640000972 ligand binding site [chemical binding]; other site 1286640000973 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286640000974 dimerization interface [polypeptide binding]; other site 1286640000975 PAS fold; Region: PAS_7; pfam12860 1286640000976 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640000977 cyclase homology domain; Region: CHD; cd07302 1286640000978 nucleotidyl binding site; other site 1286640000979 metal binding site [ion binding]; metal-binding site 1286640000980 dimer interface [polypeptide binding]; other site 1286640000981 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1286640000982 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286640000983 Walker A/P-loop; other site 1286640000984 ATP binding site [chemical binding]; other site 1286640000985 Q-loop/lid; other site 1286640000986 ABC transporter signature motif; other site 1286640000987 Walker B; other site 1286640000988 D-loop; other site 1286640000989 H-loop/switch region; other site 1286640000990 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286640000991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640000992 putative PBP binding loops; other site 1286640000993 dimer interface [polypeptide binding]; other site 1286640000994 ABC-ATPase subunit interface; other site 1286640000995 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1286640000996 NMT1-like family; Region: NMT1_2; pfam13379 1286640000997 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1286640000998 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1286640000999 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1286640001000 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1286640001001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640001002 non-specific DNA binding site [nucleotide binding]; other site 1286640001003 salt bridge; other site 1286640001004 sequence-specific DNA binding site [nucleotide binding]; other site 1286640001005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 1286640001006 Predicted integral membrane protein [Function unknown]; Region: COG5616 1286640001007 TPR repeat; Region: TPR_11; pfam13414 1286640001008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640001009 binding surface 1286640001010 TPR motif; other site 1286640001011 Predicted periplasmic protein [Function unknown]; Region: COG3900 1286640001012 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1286640001013 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1286640001014 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 1286640001015 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1286640001016 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1286640001017 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1286640001018 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1286640001019 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1286640001020 Low-spin heme binding site [chemical binding]; other site 1286640001021 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1286640001022 Putative water exit pathway; other site 1286640001023 Binuclear center (active site) [active] 1286640001024 Putative proton exit pathway; other site 1286640001025 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1286640001026 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 1286640001027 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1286640001028 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1286640001029 Cytochrome c; Region: Cytochrom_C; pfam00034 1286640001030 Cytochrome c; Region: Cytochrom_C; pfam00034 1286640001031 Predicted integral membrane protein [Function unknown]; Region: COG5473 1286640001032 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1286640001033 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286640001034 metal-binding site [ion binding] 1286640001035 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286640001036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640001037 motif II; other site 1286640001038 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 1286640001039 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1286640001040 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1286640001041 ligand binding site [chemical binding]; other site 1286640001042 Predicted periplasmic protein [Function unknown]; Region: COG3900 1286640001043 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1286640001044 amphipathic channel; other site 1286640001045 Asn-Pro-Ala signature motifs; other site 1286640001046 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1286640001047 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286640001048 FOG: CBS domain [General function prediction only]; Region: COG0517 1286640001049 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1286640001050 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1286640001051 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1286640001052 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 1286640001053 BA14K-like protein; Region: BA14K; pfam07886 1286640001054 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 1286640001055 HTH DNA binding domain; Region: HTH_13; pfam11972 1286640001056 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1286640001057 Helix-turn-helix domain; Region: HTH_38; pfam13936 1286640001058 DNA-binding interface [nucleotide binding]; DNA binding site 1286640001059 Integrase core domain; Region: rve; pfam00665 1286640001060 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1286640001061 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1286640001062 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1286640001063 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1286640001064 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 1286640001065 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286640001066 ligand binding site [chemical binding]; other site 1286640001067 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1286640001068 putative switch regulator; other site 1286640001069 non-specific DNA interactions [nucleotide binding]; other site 1286640001070 DNA binding site [nucleotide binding] 1286640001071 sequence specific DNA binding site [nucleotide binding]; other site 1286640001072 putative cAMP binding site [chemical binding]; other site 1286640001073 Predicted integral membrane protein [Function unknown]; Region: COG5616 1286640001074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640001075 TPR motif; other site 1286640001076 binding surface 1286640001077 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1286640001078 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1286640001079 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640001080 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1286640001081 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1286640001082 MULE transposase domain; Region: MULE; pfam10551 1286640001083 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1286640001084 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1286640001085 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1286640001086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640001087 substrate binding pocket [chemical binding]; other site 1286640001088 membrane-bound complex binding site; other site 1286640001089 hinge residues; other site 1286640001090 putrescine transporter; Provisional; Region: potE; PRK10655 1286640001091 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1286640001092 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1286640001093 ornithine decarboxylase; Provisional; Region: PRK13578 1286640001094 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1286640001095 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286640001096 catalytic residue [active] 1286640001097 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1286640001098 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1286640001099 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1286640001100 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1286640001101 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286640001102 catalytic residue [active] 1286640001103 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1286640001104 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: COG3965 1286640001105 arginine:agmatin antiporter; Provisional; Region: PRK10644 1286640001106 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1286640001107 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1286640001108 arginine deiminase; Provisional; Region: PRK01388 1286640001109 ornithine carbamoyltransferase; Validated; Region: PRK02102 1286640001110 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1286640001111 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1286640001112 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1286640001113 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1286640001114 putative substrate binding site [chemical binding]; other site 1286640001115 nucleotide binding site [chemical binding]; other site 1286640001116 nucleotide binding site [chemical binding]; other site 1286640001117 homodimer interface [polypeptide binding]; other site 1286640001118 Ion channel; Region: Ion_trans_2; pfam07885 1286640001119 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1286640001120 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1286640001121 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286640001122 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1286640001123 inhibitor site; inhibition site 1286640001124 active site 1286640001125 dimer interface [polypeptide binding]; other site 1286640001126 catalytic residue [active] 1286640001127 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1286640001128 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1286640001129 active site pocket [active] 1286640001130 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640001131 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640001132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640001133 dimer interface [polypeptide binding]; other site 1286640001134 conserved gate region; other site 1286640001135 putative PBP binding loops; other site 1286640001136 ABC-ATPase subunit interface; other site 1286640001137 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640001138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640001139 dimer interface [polypeptide binding]; other site 1286640001140 conserved gate region; other site 1286640001141 putative PBP binding loops; other site 1286640001142 ABC-ATPase subunit interface; other site 1286640001143 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286640001144 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640001145 Walker A/P-loop; other site 1286640001146 ATP binding site [chemical binding]; other site 1286640001147 Q-loop/lid; other site 1286640001148 ABC transporter signature motif; other site 1286640001149 Walker B; other site 1286640001150 D-loop; other site 1286640001151 H-loop/switch region; other site 1286640001152 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640001153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640001154 NAD(P) binding site [chemical binding]; other site 1286640001155 active site 1286640001156 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286640001157 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1286640001158 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286640001159 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1286640001160 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1286640001161 classical (c) SDRs; Region: SDR_c; cd05233 1286640001162 NAD(P) binding site [chemical binding]; other site 1286640001163 active site 1286640001164 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640001165 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1286640001166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640001167 Coenzyme A binding pocket [chemical binding]; other site 1286640001168 Uncharacterized conserved protein [Function unknown]; Region: COG5556 1286640001169 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 1286640001170 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286640001171 DNA-binding site [nucleotide binding]; DNA binding site 1286640001172 RNA-binding motif; other site 1286640001173 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1286640001174 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1286640001175 ring oligomerisation interface [polypeptide binding]; other site 1286640001176 ATP/Mg binding site [chemical binding]; other site 1286640001177 stacking interactions; other site 1286640001178 hinge regions; other site 1286640001179 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1286640001180 oligomerisation interface [polypeptide binding]; other site 1286640001181 mobile loop; other site 1286640001182 roof hairpin; other site 1286640001183 Predicted transcriptional regulator [Transcription]; Region: COG4957 1286640001184 Integrase core domain; Region: rve_3; pfam13683 1286640001185 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1286640001186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640001187 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640001188 dimerization interface [polypeptide binding]; other site 1286640001189 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1286640001190 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1286640001191 [2Fe-2S] cluster binding site [ion binding]; other site 1286640001192 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1286640001193 putative alpha subunit interface [polypeptide binding]; other site 1286640001194 putative active site [active] 1286640001195 putative substrate binding site [chemical binding]; other site 1286640001196 Fe binding site [ion binding]; other site 1286640001197 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1286640001198 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1286640001199 FAD binding pocket [chemical binding]; other site 1286640001200 FAD binding motif [chemical binding]; other site 1286640001201 phosphate binding motif [ion binding]; other site 1286640001202 beta-alpha-beta structure motif; other site 1286640001203 NAD binding pocket [chemical binding]; other site 1286640001204 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640001205 catalytic loop [active] 1286640001206 iron binding site [ion binding]; other site 1286640001207 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1286640001208 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1286640001209 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640001210 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640001211 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 1286640001212 putative substrate binding pocket [chemical binding]; other site 1286640001213 putative dimerization interface [polypeptide binding]; other site 1286640001214 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1286640001215 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1286640001216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1286640001217 dimerization interface [polypeptide binding]; other site 1286640001218 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1286640001219 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1286640001220 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 1286640001221 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286640001222 ligand binding site [chemical binding]; other site 1286640001223 flexible hinge region; other site 1286640001224 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1286640001225 putative switch regulator; other site 1286640001226 non-specific DNA interactions [nucleotide binding]; other site 1286640001227 DNA binding site [nucleotide binding] 1286640001228 sequence specific DNA binding site [nucleotide binding]; other site 1286640001229 putative cAMP binding site [chemical binding]; other site 1286640001230 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1286640001231 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1286640001232 Low-spin heme binding site [chemical binding]; other site 1286640001233 Putative water exit pathway; other site 1286640001234 Binuclear center (active site) [active] 1286640001235 Putative proton exit pathway; other site 1286640001236 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1286640001237 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 1286640001238 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1286640001239 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1286640001240 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1286640001241 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1286640001242 maltose O-acetyltransferase; Provisional; Region: PRK10092 1286640001243 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1286640001244 active site 1286640001245 substrate binding site [chemical binding]; other site 1286640001246 trimer interface [polypeptide binding]; other site 1286640001247 CoA binding site [chemical binding]; other site 1286640001248 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 1286640001249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640001250 S-adenosylmethionine binding site [chemical binding]; other site 1286640001251 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1286640001252 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1286640001253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640001254 Walker A motif; other site 1286640001255 ATP binding site [chemical binding]; other site 1286640001256 Walker B motif; other site 1286640001257 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640001258 Winged helix-turn helix; Region: HTH_29; pfam13551 1286640001259 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1286640001260 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1286640001261 catalytic residues [active] 1286640001262 catalytic nucleophile [active] 1286640001263 Recombinase; Region: Recombinase; pfam07508 1286640001264 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1286640001265 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640001266 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640001267 DNA-binding site [nucleotide binding]; DNA binding site 1286640001268 FCD domain; Region: FCD; pfam07729 1286640001269 Amino acid synthesis; Region: AA_synth; pfam06684 1286640001270 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286640001271 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1286640001272 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1286640001273 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1286640001274 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286640001275 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1286640001276 NAD(P) binding site [chemical binding]; other site 1286640001277 catalytic residues [active] 1286640001278 NIPSNAP; Region: NIPSNAP; pfam07978 1286640001279 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1286640001280 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286640001281 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 1286640001282 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640001283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640001284 dimer interface [polypeptide binding]; other site 1286640001285 conserved gate region; other site 1286640001286 putative PBP binding loops; other site 1286640001287 ABC-ATPase subunit interface; other site 1286640001288 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286640001289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640001290 Walker A/P-loop; other site 1286640001291 ATP binding site [chemical binding]; other site 1286640001292 Q-loop/lid; other site 1286640001293 ABC transporter signature motif; other site 1286640001294 Walker B; other site 1286640001295 D-loop; other site 1286640001296 H-loop/switch region; other site 1286640001297 TOBE domain; Region: TOBE_2; pfam08402 1286640001298 succinic semialdehyde dehydrogenase; Region: PLN02278 1286640001299 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1286640001300 tetramerization interface [polypeptide binding]; other site 1286640001301 NAD(P) binding site [chemical binding]; other site 1286640001302 catalytic residues [active] 1286640001303 Transposase; Region: HTH_Tnp_1; cl17663 1286640001304 Nitrogen fixation protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NifU; COG5554 1286640001305 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286640001306 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1286640001307 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286640001308 FeS/SAM binding site; other site 1286640001309 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 1286640001310 Nif-specific regulatory protein; Region: nifA; TIGR01817 1286640001311 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1286640001312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640001313 Walker A motif; other site 1286640001314 ATP binding site [chemical binding]; other site 1286640001315 Walker B motif; other site 1286640001316 arginine finger; other site 1286640001317 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286640001318 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1286640001319 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1286640001320 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286640001321 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1286640001322 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1286640001323 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1286640001324 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1286640001325 Ligand binding site [chemical binding]; other site 1286640001326 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1286640001327 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1286640001328 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 1286640001329 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1286640001330 Nucleotide-binding sites [chemical binding]; other site 1286640001331 Walker A motif; other site 1286640001332 Switch I region of nucleotide binding site; other site 1286640001333 Fe4S4 binding sites [ion binding]; other site 1286640001334 Switch II region of nucleotide binding site; other site 1286640001335 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 1286640001336 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 1286640001337 MoFe protein alpha/beta subunit interactions; other site 1286640001338 Alpha subunit P cluster binding residues; other site 1286640001339 FeMoco binding residues [chemical binding]; other site 1286640001340 MoFe protein alpha subunit/Fe protein contacts; other site 1286640001341 MoFe protein dimer/ dimer interactions; other site 1286640001342 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 1286640001343 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 1286640001344 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 1286640001345 MoFe protein beta/alpha subunit interactions; other site 1286640001346 Beta subunit P cluster binding residues; other site 1286640001347 MoFe protein beta subunit/Fe protein contacts; other site 1286640001348 MoFe protein dimer/ dimer interactions; other site 1286640001349 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 1286640001350 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1286640001351 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1286640001352 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5420 1286640001353 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 1286640001354 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1286640001355 Exopolysaccharide production repressor; Region: SyrA; pfam11089 1286640001356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640001357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640001358 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 1286640001359 putative substrate binding pocket [chemical binding]; other site 1286640001360 putative dimerization interface [polypeptide binding]; other site 1286640001361 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640001362 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640001363 The C-terminal substrate binding of LysR-type symbiotic regulator SyrM, which activates expression of nodulation gene NodD3, contains the type 2 periplasmic binding fold; Region: PBP2_SyrM; cd08467 1286640001364 putative substrate binding pocket [chemical binding]; other site 1286640001365 putative dimerization interface [polypeptide binding]; other site 1286640001366 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 1286640001367 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1286640001368 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1286640001369 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1286640001370 dimer interface [polypeptide binding]; other site 1286640001371 active site 1286640001372 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 1286640001373 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1286640001374 NAD(P) binding site [chemical binding]; other site 1286640001375 homotetramer interface [polypeptide binding]; other site 1286640001376 homodimer interface [polypeptide binding]; other site 1286640001377 active site 1286640001378 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1286640001379 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1286640001380 Active Sites [active] 1286640001381 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1286640001382 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1286640001383 CysD dimerization site [polypeptide binding]; other site 1286640001384 G1 box; other site 1286640001385 putative GEF interaction site [polypeptide binding]; other site 1286640001386 GTP/Mg2+ binding site [chemical binding]; other site 1286640001387 Switch I region; other site 1286640001388 G2 box; other site 1286640001389 G3 box; other site 1286640001390 Switch II region; other site 1286640001391 G4 box; other site 1286640001392 G5 box; other site 1286640001393 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1286640001394 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1286640001395 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1286640001396 ligand-binding site [chemical binding]; other site 1286640001397 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1286640001398 ABC-2 type transporter, NodJ family; Region: nodJ; TIGR01291 1286640001399 nodulation factor exporter subunit NodI; Provisional; Region: PRK13536 1286640001400 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286640001401 Walker A/P-loop; other site 1286640001402 ATP binding site [chemical binding]; other site 1286640001403 Q-loop/lid; other site 1286640001404 ABC transporter signature motif; other site 1286640001405 Walker B; other site 1286640001406 D-loop; other site 1286640001407 H-loop/switch region; other site 1286640001408 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 1286640001409 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1286640001410 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1286640001411 DXD motif; other site 1286640001412 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1286640001413 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1286640001414 Nodulation protein A (NodA); Region: NodA; pfam02474 1286640001415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640001416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640001417 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 1286640001418 putative substrate binding pocket [chemical binding]; other site 1286640001419 putative dimerization interface [polypeptide binding]; other site 1286640001420 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1286640001421 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1286640001422 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1286640001423 putative active site [active] 1286640001424 putative catalytic site [active] 1286640001425 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1286640001426 Protein export membrane protein; Region: SecD_SecF; cl14618 1286640001427 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286640001428 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640001429 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1286640001430 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1286640001431 glutaminase active site [active] 1286640001432 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1286640001433 dimer interface [polypeptide binding]; other site 1286640001434 active site 1286640001435 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1286640001436 dimer interface [polypeptide binding]; other site 1286640001437 active site 1286640001438 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1286640001439 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1286640001440 Uncharacterized conserved protein [Function unknown]; Region: COG4544 1286640001441 DNA Polymerase Y-family; Region: PolY_like; cd03468 1286640001442 active site 1286640001443 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1286640001444 DNA binding site [nucleotide binding] 1286640001445 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1286640001446 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1286640001447 putative active site [active] 1286640001448 putative PHP Thumb interface [polypeptide binding]; other site 1286640001449 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1286640001450 generic binding surface I; other site 1286640001451 generic binding surface II; other site 1286640001452 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1286640001453 Antirestriction protein; Region: Antirestrict; pfam03230 1286640001454 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 1286640001455 Helicase_C-like; Region: Helicase_C_4; pfam13871 1286640001456 Toprim domain; Region: Toprim_3; pfam13362 1286640001457 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 1286640001458 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1286640001459 putative active site [active] 1286640001460 Uncharacterized conserved protein [Function unknown]; Region: COG5489 1286640001461 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 1286640001462 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 1286640001463 Walker A motif; other site 1286640001464 ATP binding site [chemical binding]; other site 1286640001465 Walker B motif; other site 1286640001466 Conjugal transfer protein TraD; Region: TraD; pfam06412 1286640001467 TraC-like protein; Region: TraC; pfam07820 1286640001468 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 1286640001469 MobA/MobL family; Region: MobA_MobL; pfam03389 1286640001470 AAA domain; Region: AAA_30; pfam13604 1286640001471 Family description; Region: UvrD_C_2; pfam13538 1286640001472 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1286640001473 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286640001474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640001475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640001476 dimer interface [polypeptide binding]; other site 1286640001477 phosphorylation site [posttranslational modification] 1286640001478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640001479 ATP binding site [chemical binding]; other site 1286640001480 Mg2+ binding site [ion binding]; other site 1286640001481 G-X-G motif; other site 1286640001482 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1286640001483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640001484 active site 1286640001485 phosphorylation site [posttranslational modification] 1286640001486 intermolecular recognition site; other site 1286640001487 dimerization interface [polypeptide binding]; other site 1286640001488 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640001489 DNA binding residues [nucleotide binding] 1286640001490 dimerization interface [polypeptide binding]; other site 1286640001491 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640001492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640001493 active site 1286640001494 phosphorylation site [posttranslational modification] 1286640001495 intermolecular recognition site; other site 1286640001496 dimerization interface [polypeptide binding]; other site 1286640001497 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1286640001498 Sulfatase; Region: Sulfatase; pfam00884 1286640001499 Sulfatase; Region: Sulfatase; cl17466 1286640001500 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1286640001501 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640001502 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640001503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640001504 dimer interface [polypeptide binding]; other site 1286640001505 conserved gate region; other site 1286640001506 putative PBP binding loops; other site 1286640001507 ABC-ATPase subunit interface; other site 1286640001508 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286640001509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640001510 dimer interface [polypeptide binding]; other site 1286640001511 conserved gate region; other site 1286640001512 putative PBP binding loops; other site 1286640001513 ABC-ATPase subunit interface; other site 1286640001514 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286640001515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640001516 Walker A/P-loop; other site 1286640001517 ATP binding site [chemical binding]; other site 1286640001518 Q-loop/lid; other site 1286640001519 ABC transporter signature motif; other site 1286640001520 Walker B; other site 1286640001521 D-loop; other site 1286640001522 H-loop/switch region; other site 1286640001523 TOBE domain; Region: TOBE_2; pfam08402 1286640001524 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640001525 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640001526 DNA-binding site [nucleotide binding]; DNA binding site 1286640001527 FCD domain; Region: FCD; pfam07729 1286640001528 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1286640001529 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640001530 inhibitor-cofactor binding pocket; inhibition site 1286640001531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640001532 catalytic residue [active] 1286640001533 acetolactate synthase catalytic subunit; Validated; Region: PRK06112 1286640001534 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286640001535 PYR/PP interface [polypeptide binding]; other site 1286640001536 dimer interface [polypeptide binding]; other site 1286640001537 TPP binding site [chemical binding]; other site 1286640001538 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286640001539 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1286640001540 TPP-binding site [chemical binding]; other site 1286640001541 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1286640001542 classical (c) SDRs; Region: SDR_c; cd05233 1286640001543 NAD(P) binding site [chemical binding]; other site 1286640001544 active site 1286640001545 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640001546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640001547 active site 1286640001548 phosphorylation site [posttranslational modification] 1286640001549 intermolecular recognition site; other site 1286640001550 dimerization interface [polypeptide binding]; other site 1286640001551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640001552 DNA binding site [nucleotide binding] 1286640001553 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1286640001554 active site 1286640001555 NTP binding site [chemical binding]; other site 1286640001556 metal binding triad [ion binding]; metal-binding site 1286640001557 antibiotic binding site [chemical binding]; other site 1286640001558 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748 1286640001559 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640001560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1286640001561 active site 1286640001562 phosphorylation site [posttranslational modification] 1286640001563 intermolecular recognition site; other site 1286640001564 dimerization interface [polypeptide binding]; other site 1286640001565 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640001566 DNA binding site [nucleotide binding] 1286640001567 hypothetical protein; Provisional; Region: PRK07505 1286640001568 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1286640001569 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286640001570 catalytic residue [active] 1286640001571 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1286640001572 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1286640001573 DNA-binding interface [nucleotide binding]; DNA binding site 1286640001574 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640001575 Integrase core domain; Region: rve; pfam00665 1286640001576 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1286640001577 oligomeric interface; other site 1286640001578 putative active site [active] 1286640001579 homodimer interface [polypeptide binding]; other site 1286640001580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640001581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640001582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640001583 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1286640001584 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1286640001585 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1286640001586 MULE transposase domain; Region: MULE; pfam10551 1286640001587 MULE transposase domain; Region: MULE; pfam10551 1286640001588 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1286640001589 HWE histidine kinase; Region: HWE_HK; pfam07536 1286640001590 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 1286640001591 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1286640001592 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1286640001593 Predicted metal-binding protein [General function prediction only]; Region: COG3019 1286640001594 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286640001595 metal-binding site [ion binding] 1286640001596 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1286640001597 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286640001598 metal-binding site [ion binding] 1286640001599 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1286640001600 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286640001601 metal-binding site [ion binding] 1286640001602 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286640001603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640001604 motif II; other site 1286640001605 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1286640001606 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1286640001607 DNA binding residues [nucleotide binding] 1286640001608 dimer interface [polypeptide binding]; other site 1286640001609 copper binding site [ion binding]; other site 1286640001610 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1286640001611 Cytochrome C' Region: Cytochrom_C_2; cl01610 1286640001612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 1286640001613 Predicted membrane protein [Function unknown]; Region: COG1238 1286640001614 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 1286640001615 HTH-like domain; Region: HTH_21; pfam13276 1286640001616 Integrase core domain; Region: rve; pfam00665 1286640001617 Integrase core domain; Region: rve_3; pfam13683 1286640001618 Transposase; Region: HTH_Tnp_1; cl17663 1286640001619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286640001620 Predicted membrane protein [Function unknown]; Region: COG1238 1286640001621 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1286640001622 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1286640001623 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1286640001624 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1286640001625 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1286640001626 Uncharacterized conserved protein [Function unknown]; Region: COG5569 1286640001627 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640001628 cyclase homology domain; Region: CHD; cd07302 1286640001629 nucleotidyl binding site; other site 1286640001630 metal binding site [ion binding]; metal-binding site 1286640001631 dimer interface [polypeptide binding]; other site 1286640001632 Predicted transporter component [General function prediction only]; Region: COG2391 1286640001633 Sulphur transport; Region: Sulf_transp; pfam04143 1286640001634 Predicted transporter component [General function prediction only]; Region: COG2391 1286640001635 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 1286640001636 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640001637 dimerization interface [polypeptide binding]; other site 1286640001638 putative DNA binding site [nucleotide binding]; other site 1286640001639 putative Zn2+ binding site [ion binding]; other site 1286640001640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 1286640001641 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1286640001642 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1286640001643 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1286640001644 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1286640001645 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1286640001646 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1286640001647 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 1286640001648 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286640001649 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286640001650 ligand binding site [chemical binding]; other site 1286640001651 flexible hinge region; other site 1286640001652 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1286640001653 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1286640001654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286640001655 Integrase core domain; Region: rve; pfam00665 1286640001656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286640001657 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1286640001658 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1286640001659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640001660 Walker A motif; other site 1286640001661 ATP binding site [chemical binding]; other site 1286640001662 Walker B motif; other site 1286640001663 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286640001664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640001665 non-specific DNA binding site [nucleotide binding]; other site 1286640001666 salt bridge; other site 1286640001667 sequence-specific DNA binding site [nucleotide binding]; other site 1286640001668 Cupin domain; Region: Cupin_2; pfam07883 1286640001669 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1286640001670 Fasciclin domain; Region: Fasciclin; pfam02469 1286640001671 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1286640001672 TspO/MBR family; Region: TspO_MBR; pfam03073 1286640001673 LTXXQ motif family protein; Region: LTXXQ; pfam07813 1286640001674 putative phosphoketolase; Provisional; Region: PRK05261 1286640001675 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1286640001676 TPP-binding site; other site 1286640001677 XFP C-terminal domain; Region: XFP_C; pfam09363 1286640001678 FOG: CBS domain [General function prediction only]; Region: COG0517 1286640001679 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1286640001680 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1286640001681 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286640001682 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1286640001683 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1286640001684 hydrophobic ligand binding site; other site 1286640001685 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286640001686 Ligand Binding Site [chemical binding]; other site 1286640001687 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1286640001688 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1286640001689 Cytochrome c; Region: Cytochrom_C; pfam00034 1286640001690 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286640001691 Ligand Binding Site [chemical binding]; other site 1286640001692 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1286640001693 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640001694 cyclase homology domain; Region: CHD; cd07302 1286640001695 nucleotidyl binding site; other site 1286640001696 metal binding site [ion binding]; metal-binding site 1286640001697 dimer interface [polypeptide binding]; other site 1286640001698 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286640001699 Cytochrome c; Region: Cytochrom_C; pfam00034 1286640001700 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640001701 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286640001702 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286640001703 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1286640001704 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1286640001705 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1286640001706 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1286640001707 putative dimer interface [polypeptide binding]; other site 1286640001708 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286640001709 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286640001710 Walker A/P-loop; other site 1286640001711 ATP binding site [chemical binding]; other site 1286640001712 Q-loop/lid; other site 1286640001713 ABC transporter signature motif; other site 1286640001714 Walker B; other site 1286640001715 D-loop; other site 1286640001716 H-loop/switch region; other site 1286640001717 FtsX-like permease family; Region: FtsX; pfam02687 1286640001718 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286640001719 FtsX-like permease family; Region: FtsX; pfam02687 1286640001720 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286640001721 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640001722 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1286640001723 Peptidase family M50; Region: Peptidase_M50; pfam02163 1286640001724 active site 1286640001725 putative substrate binding region [chemical binding]; other site 1286640001726 FOG: CBS domain [General function prediction only]; Region: COG0517 1286640001727 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 1286640001728 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1286640001729 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1286640001730 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286640001731 protein binding site [polypeptide binding]; other site 1286640001732 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286640001733 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1286640001734 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286640001735 Beta-Casp domain; Region: Beta-Casp; smart01027 1286640001736 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1286640001737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1286640001738 active site 1286640001739 dimerization interface [polypeptide binding]; other site 1286640001740 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640001741 DNA binding site [nucleotide binding] 1286640001742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640001743 active site 1286640001744 phosphorylation site [posttranslational modification] 1286640001745 intermolecular recognition site; other site 1286640001746 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286640001747 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286640001748 ligand binding site [chemical binding]; other site 1286640001749 flexible hinge region; other site 1286640001750 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1286640001751 putative switch regulator; other site 1286640001752 non-specific DNA interactions [nucleotide binding]; other site 1286640001753 DNA binding site [nucleotide binding] 1286640001754 sequence specific DNA binding site [nucleotide binding]; other site 1286640001755 putative cAMP binding site [chemical binding]; other site 1286640001756 PAS domain S-box; Region: sensory_box; TIGR00229 1286640001757 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640001758 putative active site [active] 1286640001759 heme pocket [chemical binding]; other site 1286640001760 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640001761 dimer interface [polypeptide binding]; other site 1286640001762 phosphorylation site [posttranslational modification] 1286640001763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640001764 ATP binding site [chemical binding]; other site 1286640001765 Mg2+ binding site [ion binding]; other site 1286640001766 G-X-G motif; other site 1286640001767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640001768 active site 1286640001769 phosphorylation site [posttranslational modification] 1286640001770 intermolecular recognition site; other site 1286640001771 dimerization interface [polypeptide binding]; other site 1286640001772 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1286640001773 CoA binding domain; Region: CoA_binding_2; pfam13380 1286640001774 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1286640001775 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1286640001776 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286640001777 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640001778 Coenzyme A binding pocket [chemical binding]; other site 1286640001779 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286640001780 Ligand Binding Site [chemical binding]; other site 1286640001781 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286640001782 Ligand Binding Site [chemical binding]; other site 1286640001783 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1286640001784 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1286640001785 BON domain; Region: BON; pfam04972 1286640001786 BON domain; Region: BON; pfam04972 1286640001787 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1286640001788 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1286640001789 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286640001790 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1286640001791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640001792 motif II; other site 1286640001793 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1286640001794 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286640001795 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 1286640001796 tetramer interface [polypeptide binding]; other site 1286640001797 catalytic Zn binding site [ion binding]; other site 1286640001798 NADP binding site [chemical binding]; other site 1286640001799 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286640001800 Ligand Binding Site [chemical binding]; other site 1286640001801 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1286640001802 Predicted membrane protein [Function unknown]; Region: COG3174 1286640001803 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1286640001804 Predicted membrane protein [Function unknown]; Region: COG3174 1286640001805 Predicted membrane protein [Function unknown]; Region: COG3619 1286640001806 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1286640001807 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286640001808 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286640001809 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1286640001810 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286640001811 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286640001812 Cytochrome c; Region: Cytochrom_C; cl11414 1286640001813 Integrase core domain; Region: rve; pfam00665 1286640001814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286640001815 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1286640001816 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1286640001817 diiron binding motif [ion binding]; other site 1286640001818 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 1286640001819 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1286640001820 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1286640001821 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1286640001822 nitrous-oxide reductase; Validated; Region: PRK02888 1286640001823 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1286640001824 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 1286640001825 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1286640001826 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286640001827 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286640001828 Walker A/P-loop; other site 1286640001829 ATP binding site [chemical binding]; other site 1286640001830 Q-loop/lid; other site 1286640001831 ABC transporter signature motif; other site 1286640001832 Walker B; other site 1286640001833 D-loop; other site 1286640001834 H-loop/switch region; other site 1286640001835 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1286640001836 Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314 1286640001837 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1286640001838 ApbE family; Region: ApbE; pfam02424 1286640001839 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1286640001840 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1286640001841 heme-binding site [chemical binding]; other site 1286640001842 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1286640001843 FAD binding pocket [chemical binding]; other site 1286640001844 FAD binding motif [chemical binding]; other site 1286640001845 phosphate binding motif [ion binding]; other site 1286640001846 beta-alpha-beta structure motif; other site 1286640001847 NAD binding pocket [chemical binding]; other site 1286640001848 Heme binding pocket [chemical binding]; other site 1286640001849 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 1286640001850 Regulator of cell morphogenesis and NO signaling [Cell division and chromosome partitioning]; Region: COG2846 1286640001851 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1286640001852 Hemerythrin-like domain; Region: Hr-like; cd12108 1286640001853 Fe binding site [ion binding]; other site 1286640001854 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1286640001855 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1286640001856 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1286640001857 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286640001858 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286640001859 ligand binding site [chemical binding]; other site 1286640001860 flexible hinge region; other site 1286640001861 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1286640001862 cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847 1286640001863 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1286640001864 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286640001865 metal-binding site [ion binding] 1286640001866 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286640001867 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1286640001868 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 1286640001869 FixH; Region: FixH; pfam05751 1286640001870 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1286640001871 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1286640001872 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1286640001873 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1286640001874 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1286640001875 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1286640001876 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1286640001877 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1286640001878 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 1286640001879 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1286640001880 Low-spin heme binding site [chemical binding]; other site 1286640001881 Putative water exit pathway; other site 1286640001882 Binuclear center (active site) [active] 1286640001883 Putative proton exit pathway; other site 1286640001884 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1286640001885 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 1286640001886 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286640001887 ligand binding site [chemical binding]; other site 1286640001888 flexible hinge region; other site 1286640001889 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1286640001890 putative switch regulator; other site 1286640001891 non-specific DNA interactions [nucleotide binding]; other site 1286640001892 DNA binding site [nucleotide binding] 1286640001893 sequence specific DNA binding site [nucleotide binding]; other site 1286640001894 putative cAMP binding site [chemical binding]; other site 1286640001895 response regulator FixJ; Provisional; Region: fixJ; PRK09390 1286640001896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640001897 active site 1286640001898 phosphorylation site [posttranslational modification] 1286640001899 intermolecular recognition site; other site 1286640001900 dimerization interface [polypeptide binding]; other site 1286640001901 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640001902 DNA binding residues [nucleotide binding] 1286640001903 dimerization interface [polypeptide binding]; other site 1286640001904 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1286640001905 PAS domain S-box; Region: sensory_box; TIGR00229 1286640001906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640001907 putative active site [active] 1286640001908 heme pocket [chemical binding]; other site 1286640001909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640001910 dimer interface [polypeptide binding]; other site 1286640001911 phosphorylation site [posttranslational modification] 1286640001912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640001913 ATP binding site [chemical binding]; other site 1286640001914 Mg2+ binding site [ion binding]; other site 1286640001915 G-X-G motif; other site 1286640001916 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286640001917 Ligand Binding Site [chemical binding]; other site 1286640001918 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 1286640001919 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1286640001920 Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043 1286640001921 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1286640001922 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1286640001923 [4Fe-4S] binding site [ion binding]; other site 1286640001924 molybdopterin cofactor binding site; other site 1286640001925 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1286640001926 molybdopterin cofactor binding site; other site 1286640001927 Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062 1286640001928 ferredoxin-type protein; Provisional; Region: PRK10194 1286640001929 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1286640001930 4Fe-4S binding domain; Region: Fer4; pfam00037 1286640001931 Periplasmic nitrate reductase system, NapE component [Energy production and conversion]; Region: NapE; COG4459 1286640001932 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1286640001933 pseudoazurin; Region: pseudoazurin; TIGR02375 1286640001934 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286640001935 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286640001936 ligand binding site [chemical binding]; other site 1286640001937 flexible hinge region; other site 1286640001938 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1286640001939 putative switch regulator; other site 1286640001940 non-specific DNA interactions [nucleotide binding]; other site 1286640001941 DNA binding site [nucleotide binding] 1286640001942 sequence specific DNA binding site [nucleotide binding]; other site 1286640001943 putative cAMP binding site [chemical binding]; other site 1286640001944 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1286640001945 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1286640001946 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1286640001947 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1286640001948 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1286640001949 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 1286640001950 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640001951 dimerization interface [polypeptide binding]; other site 1286640001952 putative DNA binding site [nucleotide binding]; other site 1286640001953 putative Zn2+ binding site [ion binding]; other site 1286640001954 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1286640001955 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1286640001956 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1286640001957 Uncharacterized conserved protein [Function unknown]; Region: COG4309 1286640001958 Pirin-related protein [General function prediction only]; Region: COG1741 1286640001959 Pirin; Region: Pirin; pfam02678 1286640001960 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1286640001961 LabA_like proteins; Region: LabA_like/DUF88; cl10034 1286640001962 putative metal binding site [ion binding]; other site 1286640001963 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1286640001964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286640001965 FeS/SAM binding site; other site 1286640001966 HemN C-terminal domain; Region: HemN_C; pfam06969 1286640001967 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1286640001968 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1286640001969 metal ion-dependent adhesion site (MIDAS); other site 1286640001970 MoxR-like ATPases [General function prediction only]; Region: COG0714 1286640001971 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1286640001972 Walker A motif; other site 1286640001973 ATP binding site [chemical binding]; other site 1286640001974 Walker B motif; other site 1286640001975 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1286640001976 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1286640001977 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1286640001978 D-pathway; other site 1286640001979 K-pathway; other site 1286640001980 Binuclear center (active site) [active] 1286640001981 Putative proton exit pathway; other site 1286640001982 Cytochrome c; Region: Cytochrom_C; pfam00034 1286640001983 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1286640001984 Subunit I/III interface [polypeptide binding]; other site 1286640001985 Predicted membrane protein [Function unknown]; Region: COG4094 1286640001986 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1286640001987 Flavoprotein; Region: Flavoprotein; pfam02441 1286640001988 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1286640001989 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1286640001990 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1286640001991 Peptidase family U32; Region: Peptidase_U32; pfam01136 1286640001992 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1286640001993 putative protease; Provisional; Region: PRK15447 1286640001994 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1286640001995 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1286640001996 NAD binding site [chemical binding]; other site 1286640001997 substrate binding site [chemical binding]; other site 1286640001998 catalytic Zn binding site [ion binding]; other site 1286640001999 tetramer interface [polypeptide binding]; other site 1286640002000 structural Zn binding site [ion binding]; other site 1286640002001 Predicted membrane protein [Function unknown]; Region: COG3619 1286640002002 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640002003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640002004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640002005 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286640002006 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1286640002007 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1286640002008 Walker A motif; other site 1286640002009 hexamer interface [polypeptide binding]; other site 1286640002010 ATP binding site [chemical binding]; other site 1286640002011 Walker B motif; other site 1286640002012 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 1286640002013 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1286640002014 VirB7 interaction site; other site 1286640002015 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 1286640002016 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 1286640002017 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 1286640002018 Type IV secretion system proteins; Region: T4SS; pfam07996 1286640002019 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 1286640002020 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1286640002021 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 1286640002022 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 1286640002023 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1286640002024 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1286640002025 N-terminal domain interface [polypeptide binding]; other site 1286640002026 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1286640002027 RibD C-terminal domain; Region: RibD_C; cl17279 1286640002028 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286640002029 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286640002030 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1286640002031 TAP-like protein; Region: Abhydrolase_4; pfam08386 1286640002032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640002033 metabolite-proton symporter; Region: 2A0106; TIGR00883 1286640002034 putative substrate translocation pore; other site 1286640002035 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1286640002036 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1286640002037 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1286640002038 active site 1286640002039 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 1286640002040 Cupin domain; Region: Cupin_2; pfam07883 1286640002041 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 1286640002042 Uncharacterized conserved protein [Function unknown]; Region: COG5441 1286640002043 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 1286640002044 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640002045 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640002046 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1286640002047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640002048 conserved gate region; other site 1286640002049 dimer interface [polypeptide binding]; other site 1286640002050 putative PBP binding loops; other site 1286640002051 ABC-ATPase subunit interface; other site 1286640002052 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640002053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640002054 dimer interface [polypeptide binding]; other site 1286640002055 conserved gate region; other site 1286640002056 putative PBP binding loops; other site 1286640002057 ABC-ATPase subunit interface; other site 1286640002058 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286640002059 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640002060 Walker A/P-loop; other site 1286640002061 ATP binding site [chemical binding]; other site 1286640002062 Q-loop/lid; other site 1286640002063 ABC transporter signature motif; other site 1286640002064 Walker B; other site 1286640002065 D-loop; other site 1286640002066 H-loop/switch region; other site 1286640002067 TOBE domain; Region: TOBE_2; pfam08402 1286640002068 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286640002069 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640002070 Walker A/P-loop; other site 1286640002071 ATP binding site [chemical binding]; other site 1286640002072 Q-loop/lid; other site 1286640002073 ABC transporter signature motif; other site 1286640002074 Walker B; other site 1286640002075 D-loop; other site 1286640002076 H-loop/switch region; other site 1286640002077 TOBE domain; Region: TOBE_2; pfam08402 1286640002078 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1286640002079 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1286640002080 ligand binding site [chemical binding]; other site 1286640002081 NAD binding site [chemical binding]; other site 1286640002082 dimerization interface [polypeptide binding]; other site 1286640002083 catalytic site [active] 1286640002084 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640002085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640002086 DNA-binding site [nucleotide binding]; DNA binding site 1286640002087 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286640002088 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1286640002089 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1286640002090 active site pocket [active] 1286640002091 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286640002092 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1286640002093 DNA interaction; other site 1286640002094 Metal-binding active site; metal-binding site 1286640002095 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286640002096 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1286640002097 Metal-binding active site; metal-binding site 1286640002098 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1286640002099 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1286640002100 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1286640002101 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1286640002102 MULE transposase domain; Region: MULE; pfam10551 1286640002103 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1286640002104 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640002105 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 1286640002106 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640002107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640002108 dimer interface [polypeptide binding]; other site 1286640002109 conserved gate region; other site 1286640002110 putative PBP binding loops; other site 1286640002111 ABC-ATPase subunit interface; other site 1286640002112 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1286640002113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640002114 dimer interface [polypeptide binding]; other site 1286640002115 putative PBP binding loops; other site 1286640002116 ABC-ATPase subunit interface; other site 1286640002117 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640002118 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286640002119 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1286640002120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640002121 Walker A/P-loop; other site 1286640002122 ATP binding site [chemical binding]; other site 1286640002123 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286640002124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640002125 H-loop/switch region; other site 1286640002126 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640002127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640002128 NAD(P) binding site [chemical binding]; other site 1286640002129 active site 1286640002130 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1286640002131 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640002132 Walker A/P-loop; other site 1286640002133 ATP binding site [chemical binding]; other site 1286640002134 Q-loop/lid; other site 1286640002135 ABC transporter signature motif; other site 1286640002136 Walker B; other site 1286640002137 D-loop; other site 1286640002138 H-loop/switch region; other site 1286640002139 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286640002140 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286640002141 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640002142 Walker A/P-loop; other site 1286640002143 ATP binding site [chemical binding]; other site 1286640002144 Q-loop/lid; other site 1286640002145 ABC transporter signature motif; other site 1286640002146 Walker B; other site 1286640002147 D-loop; other site 1286640002148 H-loop/switch region; other site 1286640002149 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640002150 dipeptide transporter; Provisional; Region: PRK10913 1286640002151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640002152 dimer interface [polypeptide binding]; other site 1286640002153 conserved gate region; other site 1286640002154 putative PBP binding loops; other site 1286640002155 ABC-ATPase subunit interface; other site 1286640002156 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640002157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640002158 dimer interface [polypeptide binding]; other site 1286640002159 conserved gate region; other site 1286640002160 putative PBP binding loops; other site 1286640002161 ABC-ATPase subunit interface; other site 1286640002162 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640002163 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1286640002164 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1286640002165 Amidase; Region: Amidase; cl11426 1286640002166 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640002167 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1286640002168 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1286640002169 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1286640002170 catalytic loop [active] 1286640002171 iron binding site [ion binding]; other site 1286640002172 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640002173 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286640002174 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640002175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640002176 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286640002177 dimerization interface [polypeptide binding]; other site 1286640002178 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1286640002179 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1286640002180 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1286640002181 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1286640002182 Ligand binding site [chemical binding]; other site 1286640002183 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1286640002184 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1286640002185 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1286640002186 Metal-binding active site; metal-binding site 1286640002187 Protein of unknown function (DUF993); Region: DUF993; pfam06187 1286640002188 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1286640002189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640002190 NAD(P) binding site [chemical binding]; other site 1286640002191 active site 1286640002192 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286640002193 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286640002194 active site 1286640002195 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640002196 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640002197 active site 1286640002198 catalytic tetrad [active] 1286640002199 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1286640002200 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1286640002201 MOFRL family; Region: MOFRL; pfam05161 1286640002202 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1286640002203 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286640002204 substrate binding site [chemical binding]; other site 1286640002205 oxyanion hole (OAH) forming residues; other site 1286640002206 trimer interface [polypeptide binding]; other site 1286640002207 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1286640002208 Coenzyme A transferase; Region: CoA_trans; smart00882 1286640002209 Coenzyme A transferase; Region: CoA_trans; cl17247 1286640002210 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640002211 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640002212 active site 1286640002213 catalytic tetrad [active] 1286640002214 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1286640002215 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1286640002216 choline dehydrogenase; Validated; Region: PRK02106 1286640002217 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1286640002218 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286640002219 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 1286640002220 NAD(P) binding site [chemical binding]; other site 1286640002221 catalytic residues [active] 1286640002222 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286640002223 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286640002224 NAD(P) binding site [chemical binding]; other site 1286640002225 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640002226 TM-ABC transporter signature motif; other site 1286640002227 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640002228 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640002229 Walker A/P-loop; other site 1286640002230 ATP binding site [chemical binding]; other site 1286640002231 Q-loop/lid; other site 1286640002232 ABC transporter signature motif; other site 1286640002233 Walker B; other site 1286640002234 D-loop; other site 1286640002235 H-loop/switch region; other site 1286640002236 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640002237 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640002238 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640002239 TM-ABC transporter signature motif; other site 1286640002240 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640002241 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1286640002242 ligand binding site [chemical binding]; other site 1286640002243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640002244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640002245 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286640002246 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286640002247 NAD(P) binding site [chemical binding]; other site 1286640002248 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640002249 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1286640002250 active site 1286640002251 metal binding site [ion binding]; metal-binding site 1286640002252 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1286640002253 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640002254 Walker A/P-loop; other site 1286640002255 ATP binding site [chemical binding]; other site 1286640002256 Q-loop/lid; other site 1286640002257 ABC transporter signature motif; other site 1286640002258 Walker B; other site 1286640002259 D-loop; other site 1286640002260 H-loop/switch region; other site 1286640002261 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1286640002262 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640002263 Walker A/P-loop; other site 1286640002264 ATP binding site [chemical binding]; other site 1286640002265 Q-loop/lid; other site 1286640002266 ABC transporter signature motif; other site 1286640002267 Walker B; other site 1286640002268 D-loop; other site 1286640002269 H-loop/switch region; other site 1286640002270 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640002271 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286640002272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640002273 dimer interface [polypeptide binding]; other site 1286640002274 conserved gate region; other site 1286640002275 putative PBP binding loops; other site 1286640002276 ABC-ATPase subunit interface; other site 1286640002277 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640002278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640002279 dimer interface [polypeptide binding]; other site 1286640002280 conserved gate region; other site 1286640002281 putative PBP binding loops; other site 1286640002282 ABC-ATPase subunit interface; other site 1286640002283 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640002284 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 1286640002285 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1286640002286 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286640002287 putative active site [active] 1286640002288 catalytic residue [active] 1286640002289 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640002290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640002291 DNA-binding site [nucleotide binding]; DNA binding site 1286640002292 FCD domain; Region: FCD; pfam07729 1286640002293 Ferritin-like domain; Region: Ferritin_2; pfam13668 1286640002294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640002295 putative substrate translocation pore; other site 1286640002296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640002297 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1286640002298 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286640002299 dimer interface [polypeptide binding]; other site 1286640002300 active site 1286640002301 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1286640002302 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1286640002303 NAD binding site [chemical binding]; other site 1286640002304 homodimer interface [polypeptide binding]; other site 1286640002305 homotetramer interface [polypeptide binding]; other site 1286640002306 active site 1286640002307 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1286640002308 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640002309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640002310 Uncharacterized conserved protein [Function unknown]; Region: COG5654 1286640002311 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1286640002312 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1286640002313 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1286640002314 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1286640002315 active site pocket [active] 1286640002316 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1286640002317 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1286640002318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640002319 dimer interface [polypeptide binding]; other site 1286640002320 conserved gate region; other site 1286640002321 putative PBP binding loops; other site 1286640002322 ABC-ATPase subunit interface; other site 1286640002323 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1286640002324 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1286640002325 Walker A/P-loop; other site 1286640002326 ATP binding site [chemical binding]; other site 1286640002327 Q-loop/lid; other site 1286640002328 ABC transporter signature motif; other site 1286640002329 Walker B; other site 1286640002330 D-loop; other site 1286640002331 H-loop/switch region; other site 1286640002332 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 1286640002333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640002334 dimer interface [polypeptide binding]; other site 1286640002335 conserved gate region; other site 1286640002336 ABC-ATPase subunit interface; other site 1286640002337 Isochorismatase family; Region: Isochorismatase; pfam00857 1286640002338 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1286640002339 catalytic triad [active] 1286640002340 conserved cis-peptide bond; other site 1286640002341 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1286640002342 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1286640002343 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1286640002344 active site 1286640002345 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1286640002346 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1286640002347 conserved cys residue [active] 1286640002348 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640002349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640002350 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 1286640002351 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286640002352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640002353 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640002354 dimerization interface [polypeptide binding]; other site 1286640002355 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640002356 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640002357 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1286640002358 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1286640002359 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1286640002360 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1286640002361 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286640002362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640002363 putative substrate translocation pore; other site 1286640002364 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1286640002365 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640002366 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1286640002367 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1286640002368 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640002369 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640002370 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 1286640002371 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640002372 catalytic loop [active] 1286640002373 iron binding site [ion binding]; other site 1286640002374 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1286640002375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640002376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640002377 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1286640002378 putative effector binding pocket; other site 1286640002379 putative dimerization interface [polypeptide binding]; other site 1286640002380 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1286640002381 homodimer interface [polypeptide binding]; other site 1286640002382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640002383 catalytic residue [active] 1286640002384 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640002385 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1286640002386 putative C-terminal domain interface [polypeptide binding]; other site 1286640002387 putative GSH binding site (G-site) [chemical binding]; other site 1286640002388 putative dimer interface [polypeptide binding]; other site 1286640002389 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1286640002390 putative N-terminal domain interface [polypeptide binding]; other site 1286640002391 putative dimer interface [polypeptide binding]; other site 1286640002392 putative substrate binding pocket (H-site) [chemical binding]; other site 1286640002393 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1286640002394 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1286640002395 [2Fe-2S] cluster binding site [ion binding]; other site 1286640002396 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1286640002397 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1286640002398 FMN-binding pocket [chemical binding]; other site 1286640002399 flavin binding motif; other site 1286640002400 phosphate binding motif [ion binding]; other site 1286640002401 beta-alpha-beta structure motif; other site 1286640002402 NAD binding pocket [chemical binding]; other site 1286640002403 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640002404 catalytic loop [active] 1286640002405 iron binding site [ion binding]; other site 1286640002406 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1286640002407 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1286640002408 hydrophobic ligand binding site; other site 1286640002409 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1286640002410 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1286640002411 hydrophobic ligand binding site; other site 1286640002412 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640002413 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640002414 DNA-binding site [nucleotide binding]; DNA binding site 1286640002415 FCD domain; Region: FCD; pfam07729 1286640002416 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1286640002417 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1286640002418 putative ligand binding site [chemical binding]; other site 1286640002419 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1286640002420 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640002421 Walker A/P-loop; other site 1286640002422 ATP binding site [chemical binding]; other site 1286640002423 Q-loop/lid; other site 1286640002424 ABC transporter signature motif; other site 1286640002425 Walker B; other site 1286640002426 D-loop; other site 1286640002427 H-loop/switch region; other site 1286640002428 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640002429 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640002430 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1286640002431 TM-ABC transporter signature motif; other site 1286640002432 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640002433 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1286640002434 TM-ABC transporter signature motif; other site 1286640002435 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1286640002436 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1286640002437 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1286640002438 4Fe-4S binding domain; Region: Fer4; pfam00037 1286640002439 FOG: CBS domain [General function prediction only]; Region: COG0517 1286640002440 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1286640002441 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1286640002442 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640002443 catalytic loop [active] 1286640002444 iron binding site [ion binding]; other site 1286640002445 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1286640002446 4Fe-4S binding domain; Region: Fer4; pfam00037 1286640002447 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1286640002448 [4Fe-4S] binding site [ion binding]; other site 1286640002449 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1286640002450 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1286640002451 SLBB domain; Region: SLBB; pfam10531 1286640002452 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1286640002453 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 1286640002454 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1286640002455 putative dimer interface [polypeptide binding]; other site 1286640002456 [2Fe-2S] cluster binding site [ion binding]; other site 1286640002457 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1286640002458 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1286640002459 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 1286640002460 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1286640002461 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1286640002462 NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838 1286640002463 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 1286640002464 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286640002465 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 1286640002466 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286640002467 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 1286640002468 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286640002469 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1286640002470 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286640002471 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713 1286640002472 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1286640002473 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1286640002474 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1286640002475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640002476 S-adenosylmethionine binding site [chemical binding]; other site 1286640002477 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640002478 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1286640002479 putative active site [active] 1286640002480 heme pocket [chemical binding]; other site 1286640002481 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1286640002482 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640002483 putative active site [active] 1286640002484 heme pocket [chemical binding]; other site 1286640002485 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640002486 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1286640002487 putative active site [active] 1286640002488 heme pocket [chemical binding]; other site 1286640002489 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640002490 putative active site [active] 1286640002491 heme pocket [chemical binding]; other site 1286640002492 PAS fold; Region: PAS_4; pfam08448 1286640002493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640002494 putative active site [active] 1286640002495 heme pocket [chemical binding]; other site 1286640002496 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286640002497 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640002498 metal binding site [ion binding]; metal-binding site 1286640002499 active site 1286640002500 I-site; other site 1286640002501 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640002502 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640002503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640002504 active site 1286640002505 phosphorylation site [posttranslational modification] 1286640002506 intermolecular recognition site; other site 1286640002507 dimerization interface [polypeptide binding]; other site 1286640002508 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640002509 DNA binding residues [nucleotide binding] 1286640002510 dimerization interface [polypeptide binding]; other site 1286640002511 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1286640002512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640002513 TPR repeat; Region: TPR_11; pfam13414 1286640002514 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1286640002515 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286640002516 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286640002517 dimer interface [polypeptide binding]; other site 1286640002518 putative CheW interface [polypeptide binding]; other site 1286640002519 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1286640002520 putative binding surface; other site 1286640002521 active site 1286640002522 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1286640002523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640002524 ATP binding site [chemical binding]; other site 1286640002525 Mg2+ binding site [ion binding]; other site 1286640002526 G-X-G motif; other site 1286640002527 CheW-like domain; Region: CheW; pfam01584 1286640002528 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1286640002529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640002530 active site 1286640002531 phosphorylation site [posttranslational modification] 1286640002532 intermolecular recognition site; other site 1286640002533 dimerization interface [polypeptide binding]; other site 1286640002534 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1286640002535 CheB methylesterase; Region: CheB_methylest; pfam01339 1286640002536 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1286640002537 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1286640002538 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1286640002539 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1286640002540 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1286640002541 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1286640002542 ATP binding site [chemical binding]; other site 1286640002543 Walker A motif; other site 1286640002544 hexamer interface [polypeptide binding]; other site 1286640002545 Walker B motif; other site 1286640002546 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1286640002547 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1286640002548 TadE-like protein; Region: TadE; pfam07811 1286640002549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1286640002550 active site 1286640002551 dimerization interface [polypeptide binding]; other site 1286640002552 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1286640002553 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1286640002554 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1286640002555 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1286640002556 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1286640002557 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 1286640002558 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 1286640002559 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1286640002560 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1286640002561 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286640002562 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640002563 cyclase homology domain; Region: CHD; cd07302 1286640002564 nucleotidyl binding site; other site 1286640002565 metal binding site [ion binding]; metal-binding site 1286640002566 dimer interface [polypeptide binding]; other site 1286640002567 Predicted integral membrane protein [Function unknown]; Region: COG5616 1286640002568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640002569 TPR motif; other site 1286640002570 TPR repeat; Region: TPR_11; pfam13414 1286640002571 binding surface 1286640002572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640002573 binding surface 1286640002574 TPR motif; other site 1286640002575 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1286640002576 Transposase; Region: HTH_Tnp_1; cl17663 1286640002577 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1286640002578 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1286640002579 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1286640002580 active site 1286640002581 catalytic residues [active] 1286640002582 Predicted ester cyclase [General function prediction only]; Region: COG5485 1286640002583 Sterile alpha motif; Region: SAM; smart00454 1286640002584 SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487 1286640002585 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640002586 cyclase homology domain; Region: CHD; cd07302 1286640002587 nucleotidyl binding site; other site 1286640002588 metal binding site [ion binding]; metal-binding site 1286640002589 dimer interface [polypeptide binding]; other site 1286640002590 Predicted ATPase [General function prediction only]; Region: COG3899 1286640002591 AAA ATPase domain; Region: AAA_16; pfam13191 1286640002592 Predicted ATPase [General function prediction only]; Region: COG3903 1286640002593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1286640002594 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1286640002595 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1286640002596 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1286640002597 putative cation:proton antiport protein; Provisional; Region: PRK10669 1286640002598 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1286640002599 TrkA-N domain; Region: TrkA_N; pfam02254 1286640002600 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640002601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640002602 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640002603 putative effector binding pocket; other site 1286640002604 dimerization interface [polypeptide binding]; other site 1286640002605 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1286640002606 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1286640002607 FMN binding site [chemical binding]; other site 1286640002608 active site 1286640002609 substrate binding site [chemical binding]; other site 1286640002610 catalytic residue [active] 1286640002611 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1286640002612 NAD(P) binding site [chemical binding]; other site 1286640002613 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1286640002614 putative active site [active] 1286640002615 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1286640002616 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1286640002617 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1286640002618 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286640002619 active site 1286640002620 DNA binding site [nucleotide binding] 1286640002621 Int/Topo IB signature motif; other site 1286640002622 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 1286640002623 Int/Topo IB signature motif; other site 1286640002624 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1286640002625 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 1286640002626 Int/Topo IB signature motif; other site 1286640002627 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640002628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640002629 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1286640002630 substrate binding pocket [chemical binding]; other site 1286640002631 dimerization interface [polypeptide binding]; other site 1286640002632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 1286640002633 short chain dehydrogenase; Provisional; Region: PRK06523 1286640002634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640002635 NAD(P) binding site [chemical binding]; other site 1286640002636 active site 1286640002637 SnoaL-like domain; Region: SnoaL_2; pfam12680 1286640002638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640002639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640002640 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1286640002641 putative effector binding pocket; other site 1286640002642 putative dimerization interface [polypeptide binding]; other site 1286640002643 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 1286640002644 putative homodimer interface [polypeptide binding]; other site 1286640002645 putative homotetramer interface [polypeptide binding]; other site 1286640002646 putative metal binding site [ion binding]; other site 1286640002647 putative homodimer-homodimer interface [polypeptide binding]; other site 1286640002648 putative allosteric switch controlling residues; other site 1286640002649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640002650 putative substrate translocation pore; other site 1286640002651 Predicted membrane protein [Function unknown]; Region: COG1238 1286640002652 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1286640002653 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1286640002654 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1286640002655 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640002656 Walker A/P-loop; other site 1286640002657 ATP binding site [chemical binding]; other site 1286640002658 Q-loop/lid; other site 1286640002659 ABC transporter signature motif; other site 1286640002660 Walker B; other site 1286640002661 D-loop; other site 1286640002662 H-loop/switch region; other site 1286640002663 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286640002664 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286640002665 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640002666 Walker A/P-loop; other site 1286640002667 ATP binding site [chemical binding]; other site 1286640002668 Q-loop/lid; other site 1286640002669 ABC transporter signature motif; other site 1286640002670 Walker B; other site 1286640002671 D-loop; other site 1286640002672 H-loop/switch region; other site 1286640002673 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640002674 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1286640002675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640002676 dimer interface [polypeptide binding]; other site 1286640002677 conserved gate region; other site 1286640002678 putative PBP binding loops; other site 1286640002679 ABC-ATPase subunit interface; other site 1286640002680 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640002681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640002682 dimer interface [polypeptide binding]; other site 1286640002683 conserved gate region; other site 1286640002684 putative PBP binding loops; other site 1286640002685 ABC-ATPase subunit interface; other site 1286640002686 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640002687 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1286640002688 substrate binding site [chemical binding]; other site 1286640002689 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 1286640002690 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1286640002691 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640002692 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640002693 DNA-binding site [nucleotide binding]; DNA binding site 1286640002694 FCD domain; Region: FCD; pfam07729 1286640002695 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286640002696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640002697 Coenzyme A binding pocket [chemical binding]; other site 1286640002698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286640002699 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1286640002700 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286640002701 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640002702 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640002703 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 1286640002704 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1286640002705 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1286640002706 arginine deiminase; Provisional; Region: PRK01388 1286640002707 Predicted membrane protein [Function unknown]; Region: COG4803 1286640002708 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1286640002709 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1286640002710 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1286640002711 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286640002712 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1286640002713 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1286640002714 active site 1286640002715 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1286640002716 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640002717 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1286640002718 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 1286640002719 TPR repeat; Region: TPR_11; pfam13414 1286640002720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640002721 TPR motif; other site 1286640002722 binding surface 1286640002723 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1286640002724 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1286640002725 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1286640002726 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640002727 motif II; other site 1286640002728 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1286640002729 Sulfatase; Region: Sulfatase; pfam00884 1286640002730 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640002731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640002732 dimer interface [polypeptide binding]; other site 1286640002733 phosphorylation site [posttranslational modification] 1286640002734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640002735 ATP binding site [chemical binding]; other site 1286640002736 Mg2+ binding site [ion binding]; other site 1286640002737 G-X-G motif; other site 1286640002738 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1286640002739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640002740 active site 1286640002741 phosphorylation site [posttranslational modification] 1286640002742 intermolecular recognition site; other site 1286640002743 dimerization interface [polypeptide binding]; other site 1286640002744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640002745 DNA binding residues [nucleotide binding] 1286640002746 dimerization interface [polypeptide binding]; other site 1286640002747 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640002748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640002749 active site 1286640002750 phosphorylation site [posttranslational modification] 1286640002751 intermolecular recognition site; other site 1286640002752 dimerization interface [polypeptide binding]; other site 1286640002753 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1286640002754 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1286640002755 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1286640002756 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1286640002757 HWE histidine kinase; Region: HWE_HK; pfam07536 1286640002758 Transposase; Region: HTH_Tnp_1; cl17663 1286640002759 Predicted membrane protein [Function unknown]; Region: COG4292 1286640002760 Predicted transcriptional regulator [Transcription]; Region: COG4957 1286640002761 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286640002762 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286640002763 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 1286640002764 active site 1286640002765 Mn binding site [ion binding]; other site 1286640002766 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1286640002767 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286640002768 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1286640002769 active site 1286640002770 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1286640002771 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1286640002772 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1286640002773 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286640002774 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1286640002775 active site 1286640002776 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1286640002777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640002778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640002779 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640002780 putative effector binding pocket; other site 1286640002781 dimerization interface [polypeptide binding]; other site 1286640002782 Isochorismatase family; Region: Isochorismatase; pfam00857 1286640002783 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1286640002784 catalytic triad [active] 1286640002785 conserved cis-peptide bond; other site 1286640002786 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1286640002787 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1286640002788 conserved cys residue [active] 1286640002789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640002790 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1286640002791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640002792 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1286640002793 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286640002794 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286640002795 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1286640002796 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1286640002797 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1286640002798 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1286640002799 NAD(P) binding site [chemical binding]; other site 1286640002800 catalytic residues [active] 1286640002801 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 1286640002802 iron-sulfur cluster [ion binding]; other site 1286640002803 [2Fe-2S] cluster binding site [ion binding]; other site 1286640002804 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1286640002805 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1286640002806 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1286640002807 FAD binding pocket [chemical binding]; other site 1286640002808 FAD binding motif [chemical binding]; other site 1286640002809 phosphate binding motif [ion binding]; other site 1286640002810 beta-alpha-beta structure motif; other site 1286640002811 NAD binding pocket [chemical binding]; other site 1286640002812 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640002813 catalytic loop [active] 1286640002814 iron binding site [ion binding]; other site 1286640002815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640002816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640002817 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286640002818 dimerization interface [polypeptide binding]; other site 1286640002819 Predicted membrane protein [Function unknown]; Region: COG2855 1286640002820 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 1286640002821 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1286640002822 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1286640002823 FAD binding pocket [chemical binding]; other site 1286640002824 FAD binding motif [chemical binding]; other site 1286640002825 phosphate binding motif [ion binding]; other site 1286640002826 NAD binding pocket [chemical binding]; other site 1286640002827 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1286640002828 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286640002829 Walker A/P-loop; other site 1286640002830 ATP binding site [chemical binding]; other site 1286640002831 Q-loop/lid; other site 1286640002832 ABC transporter signature motif; other site 1286640002833 Walker B; other site 1286640002834 D-loop; other site 1286640002835 H-loop/switch region; other site 1286640002836 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1286640002837 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286640002838 ABC-ATPase subunit interface; other site 1286640002839 dimer interface [polypeptide binding]; other site 1286640002840 putative PBP binding regions; other site 1286640002841 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286640002842 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286640002843 ABC-ATPase subunit interface; other site 1286640002844 dimer interface [polypeptide binding]; other site 1286640002845 putative PBP binding regions; other site 1286640002846 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1286640002847 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1286640002848 intersubunit interface [polypeptide binding]; other site 1286640002849 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 1286640002850 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286640002851 N-terminal plug; other site 1286640002852 ligand-binding site [chemical binding]; other site 1286640002853 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286640002854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640002855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640002856 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640002857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640002858 dimer interface [polypeptide binding]; other site 1286640002859 conserved gate region; other site 1286640002860 putative PBP binding loops; other site 1286640002861 ABC-ATPase subunit interface; other site 1286640002862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640002863 dimer interface [polypeptide binding]; other site 1286640002864 conserved gate region; other site 1286640002865 putative PBP binding loops; other site 1286640002866 ABC-ATPase subunit interface; other site 1286640002867 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286640002868 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1286640002869 Walker A/P-loop; other site 1286640002870 ATP binding site [chemical binding]; other site 1286640002871 Q-loop/lid; other site 1286640002872 ABC transporter signature motif; other site 1286640002873 Walker B; other site 1286640002874 D-loop; other site 1286640002875 H-loop/switch region; other site 1286640002876 TOBE domain; Region: TOBE_2; pfam08402 1286640002877 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1286640002878 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286640002879 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640002880 classical (c) SDRs; Region: SDR_c; cd05233 1286640002881 NAD(P) binding site [chemical binding]; other site 1286640002882 active site 1286640002883 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640002884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640002885 DNA-binding site [nucleotide binding]; DNA binding site 1286640002886 FCD domain; Region: FCD; pfam07729 1286640002887 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1286640002888 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1286640002889 active site 1286640002890 ATP binding site [chemical binding]; other site 1286640002891 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1286640002892 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640002893 inhibitor-cofactor binding pocket; inhibition site 1286640002894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640002895 catalytic residue [active] 1286640002896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 1286640002897 Predicted membrane protein [Function unknown]; Region: COG2261 1286640002898 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1286640002899 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1286640002900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 1286640002901 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 1286640002902 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 1286640002903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640002904 Predicted membrane protein [Function unknown]; Region: COG4125 1286640002905 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1286640002906 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1286640002907 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640002908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640002909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286640002910 dimerization interface [polypeptide binding]; other site 1286640002911 Sterile alpha motif; Region: SAM; smart00454 1286640002912 SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487 1286640002913 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640002914 cyclase homology domain; Region: CHD; cd07302 1286640002915 nucleotidyl binding site; other site 1286640002916 metal binding site [ion binding]; metal-binding site 1286640002917 dimer interface [polypeptide binding]; other site 1286640002918 Predicted ATPase [General function prediction only]; Region: COG3899 1286640002919 AAA ATPase domain; Region: AAA_16; pfam13191 1286640002920 Predicted ATPase [General function prediction only]; Region: COG3903 1286640002921 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 1286640002922 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1286640002923 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1286640002924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1286640002925 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286640002926 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286640002927 putative active site [active] 1286640002928 putative NTP binding site [chemical binding]; other site 1286640002929 putative nucleic acid binding site [nucleotide binding]; other site 1286640002930 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1286640002931 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1286640002932 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640002933 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640002934 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286640002935 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286640002936 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286640002937 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1286640002938 Transmembrane secretion effector; Region: MFS_3; pfam05977 1286640002939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640002940 putative substrate translocation pore; other site 1286640002941 Predicted membrane protein [Function unknown]; Region: COG2259 1286640002942 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1286640002943 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1286640002944 active site 1286640002945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4317 1286640002946 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1286640002947 Isochorismatase family; Region: Isochorismatase; pfam00857 1286640002948 catalytic triad [active] 1286640002949 dimer interface [polypeptide binding]; other site 1286640002950 conserved cis-peptide bond; other site 1286640002951 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640002952 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640002953 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640002954 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640002955 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640002956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640002957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640002958 Helix-turn-helix domain; Region: HTH_18; pfam12833 1286640002959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640002960 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12680 1286640002961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640002962 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640002963 putative effector binding pocket; other site 1286640002964 dimerization interface [polypeptide binding]; other site 1286640002965 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286640002966 active site 1286640002967 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286640002968 Predicted esterase [General function prediction only]; Region: COG0400 1286640002969 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286640002970 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1286640002971 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1286640002972 acetylornithine deacetylase; Provisional; Region: PRK07522 1286640002973 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1286640002974 metal binding site [ion binding]; metal-binding site 1286640002975 putative dimer interface [polypeptide binding]; other site 1286640002976 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1286640002977 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1286640002978 putative ligand binding site [chemical binding]; other site 1286640002979 NAD binding site [chemical binding]; other site 1286640002980 dimerization interface [polypeptide binding]; other site 1286640002981 catalytic site [active] 1286640002982 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1286640002983 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1286640002984 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286640002985 NAD(P) binding site [chemical binding]; other site 1286640002986 catalytic residues [active] 1286640002987 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1286640002988 tartrate dehydrogenase; Region: TTC; TIGR02089 1286640002989 succinic semialdehyde dehydrogenase; Region: PLN02278 1286640002990 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1286640002991 tetramerization interface [polypeptide binding]; other site 1286640002992 NAD(P) binding site [chemical binding]; other site 1286640002993 catalytic residues [active] 1286640002994 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286640002995 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640002996 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1286640002997 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1286640002998 putative acetyltransferase; Provisional; Region: PRK03624 1286640002999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640003000 Coenzyme A binding pocket [chemical binding]; other site 1286640003001 hypothetical protein; Provisional; Region: PRK05965 1286640003002 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640003003 inhibitor-cofactor binding pocket; inhibition site 1286640003004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640003005 catalytic residue [active] 1286640003006 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1286640003007 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1286640003008 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640003009 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1286640003010 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640003011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640003012 dimer interface [polypeptide binding]; other site 1286640003013 conserved gate region; other site 1286640003014 putative PBP binding loops; other site 1286640003015 ABC-ATPase subunit interface; other site 1286640003016 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286640003017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640003018 dimer interface [polypeptide binding]; other site 1286640003019 conserved gate region; other site 1286640003020 ABC-ATPase subunit interface; other site 1286640003021 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1286640003022 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640003023 Walker A/P-loop; other site 1286640003024 ATP binding site [chemical binding]; other site 1286640003025 Q-loop/lid; other site 1286640003026 ABC transporter signature motif; other site 1286640003027 Walker B; other site 1286640003028 D-loop; other site 1286640003029 H-loop/switch region; other site 1286640003030 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640003031 Walker A/P-loop; other site 1286640003032 ATP binding site [chemical binding]; other site 1286640003033 Q-loop/lid; other site 1286640003034 ABC transporter signature motif; other site 1286640003035 Walker B; other site 1286640003036 D-loop; other site 1286640003037 H-loop/switch region; other site 1286640003038 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640003039 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640003040 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640003041 putative DNA binding site [nucleotide binding]; other site 1286640003042 putative Zn2+ binding site [ion binding]; other site 1286640003043 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640003044 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640003045 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286640003046 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1286640003047 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1286640003048 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1286640003049 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1286640003050 tetramer interface [polypeptide binding]; other site 1286640003051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640003052 catalytic residue [active] 1286640003053 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1286640003054 DNA binding site [nucleotide binding] 1286640003055 active site 1286640003056 Int/Topo IB signature motif; other site 1286640003057 catalytic residues [active] 1286640003058 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1286640003059 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286640003060 putative active site [active] 1286640003061 putative NTP binding site [chemical binding]; other site 1286640003062 putative nucleic acid binding site [nucleotide binding]; other site 1286640003063 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1286640003064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1286640003065 Sulfocyanin (SoxE); Region: SoxE; cl17563 1286640003066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640003067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640003068 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1286640003069 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286640003070 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640003071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640003072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640003073 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1286640003074 PHB binding site; other site 1286640003075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640003076 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1286640003077 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640003078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640003079 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286640003080 dimerization interface [polypeptide binding]; other site 1286640003081 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1286640003082 SelR domain; Region: SelR; pfam01641 1286640003083 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1286640003084 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1286640003085 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1286640003086 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1286640003087 active site 1286640003088 catalytic residues [active] 1286640003089 Transglycosylase; Region: Transgly; pfam00912 1286640003090 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1286640003091 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1286640003092 BA14K-like protein; Region: BA14K; pfam07886 1286640003093 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1286640003094 Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004 1286640003095 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1286640003096 transmembrane helices; other site 1286640003097 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1286640003098 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1286640003099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1286640003100 Predicted nucleotide kinase (related to CMP and AMP kinases) [Nucleotide transport and metabolism]; Region: COG1936 1286640003101 AAA domain; Region: AAA_17; pfam13207 1286640003102 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1286640003103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640003104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640003105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640003106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640003107 dimerization interface [polypeptide binding]; other site 1286640003108 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1286640003109 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286640003110 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286640003111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640003112 putative substrate translocation pore; other site 1286640003113 hypothetical protein; Provisional; Region: PRK06834 1286640003114 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1286640003115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640003116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640003117 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640003118 dimerization interface [polypeptide binding]; other site 1286640003119 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286640003120 EamA-like transporter family; Region: EamA; pfam00892 1286640003121 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286640003122 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286640003123 ligand binding site [chemical binding]; other site 1286640003124 flexible hinge region; other site 1286640003125 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1286640003126 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 1286640003127 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 1286640003128 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1286640003129 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1286640003130 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1286640003131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640003132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640003133 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1286640003134 substrate binding pocket [chemical binding]; other site 1286640003135 dimerization interface [polypeptide binding]; other site 1286640003136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640003137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640003138 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1286640003139 substrate binding pocket [chemical binding]; other site 1286640003140 dimerization interface [polypeptide binding]; other site 1286640003141 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1286640003142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640003143 NAD(P) binding site [chemical binding]; other site 1286640003144 active site 1286640003145 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286640003146 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286640003147 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286640003148 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1286640003149 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1286640003150 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1286640003151 Uncharacterized conserved protein [Function unknown]; Region: COG5607 1286640003152 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640003153 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640003154 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640003155 putative effector binding pocket; other site 1286640003156 dimerization interface [polypeptide binding]; other site 1286640003157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640003158 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1286640003159 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1286640003160 potential catalytic triad [active] 1286640003161 conserved cys residue [active] 1286640003162 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1286640003163 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1286640003164 potential catalytic triad [active] 1286640003165 conserved cys residue [active] 1286640003166 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1286640003167 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640003168 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640003169 hypothetical protein; Provisional; Region: PRK06486 1286640003170 intersubunit interface [polypeptide binding]; other site 1286640003171 active site 1286640003172 Zn2+ binding site [ion binding]; other site 1286640003173 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1286640003174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640003175 motif II; other site 1286640003176 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640003177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640003178 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640003179 dimerization interface [polypeptide binding]; other site 1286640003180 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640003181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640003182 NAD(P) binding site [chemical binding]; other site 1286640003183 active site 1286640003184 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640003185 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640003186 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640003187 putative effector binding pocket; other site 1286640003188 dimerization interface [polypeptide binding]; other site 1286640003189 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1286640003190 HicB family; Region: HicB; pfam05534 1286640003191 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 1286640003192 active site 1286640003193 catalytic triad [active] 1286640003194 oxyanion hole [active] 1286640003195 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640003196 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640003197 TM-ABC transporter signature motif; other site 1286640003198 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640003199 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640003200 TM-ABC transporter signature motif; other site 1286640003201 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640003202 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640003203 Walker A/P-loop; other site 1286640003204 ATP binding site [chemical binding]; other site 1286640003205 Q-loop/lid; other site 1286640003206 ABC transporter signature motif; other site 1286640003207 Walker B; other site 1286640003208 D-loop; other site 1286640003209 H-loop/switch region; other site 1286640003210 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640003211 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640003212 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 1286640003213 putative ligand binding site [chemical binding]; other site 1286640003214 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 1286640003215 active site 1286640003216 catalytic triad [active] 1286640003217 oxyanion hole [active] 1286640003218 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1286640003219 putative switch regulator; other site 1286640003220 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286640003221 non-specific DNA interactions [nucleotide binding]; other site 1286640003222 DNA binding site [nucleotide binding] 1286640003223 sequence specific DNA binding site [nucleotide binding]; other site 1286640003224 putative cAMP binding site [chemical binding]; other site 1286640003225 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286640003226 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286640003227 nucleotide binding site [chemical binding]; other site 1286640003228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640003229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640003230 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1286640003231 putative dimer interface [polypeptide binding]; other site 1286640003232 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640003233 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 1286640003234 PLD-like domain; Region: PLDc_2; pfam13091 1286640003235 putative active site [active] 1286640003236 catalytic site [active] 1286640003237 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 1286640003238 PLD-like domain; Region: PLDc_2; pfam13091 1286640003239 putative active site [active] 1286640003240 catalytic site [active] 1286640003241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640003242 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640003243 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640003244 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640003245 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640003246 dimerization interface [polypeptide binding]; other site 1286640003247 SnoaL-like domain; Region: SnoaL_2; pfam12680 1286640003248 short chain dehydrogenase; Provisional; Region: PRK06523 1286640003249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640003250 active site 1286640003251 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286640003252 MarR family; Region: MarR; pfam01047 1286640003253 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286640003254 Serine hydrolase; Region: Ser_hydrolase; cl17834 1286640003255 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1286640003256 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1286640003257 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640003258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640003259 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640003260 putative effector binding pocket; other site 1286640003261 dimerization interface [polypeptide binding]; other site 1286640003262 Isochorismatase family; Region: Isochorismatase; pfam00857 1286640003263 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1286640003264 catalytic triad [active] 1286640003265 dimer interface [polypeptide binding]; other site 1286640003266 conserved cis-peptide bond; other site 1286640003267 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286640003268 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1286640003269 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1286640003270 Ubiquitin-like proteins; Region: UBQ; cl00155 1286640003271 charged pocket; other site 1286640003272 hydrophobic patch; other site 1286640003273 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1286640003274 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1286640003275 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640003276 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1286640003277 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640003278 catalytic loop [active] 1286640003279 iron binding site [ion binding]; other site 1286640003280 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1286640003281 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1286640003282 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1286640003283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1286640003284 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640003285 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640003286 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1286640003287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1286640003288 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1286640003289 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1286640003290 DNA-binding interface [nucleotide binding]; DNA binding site 1286640003291 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640003292 Integrase core domain; Region: rve; pfam00665 1286640003293 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640003294 DNA binding site [nucleotide binding] 1286640003295 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640003296 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1286640003297 putative ligand binding site [chemical binding]; other site 1286640003298 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1286640003299 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1286640003300 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1286640003301 [2Fe-2S] cluster binding site [ion binding]; other site 1286640003302 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1286640003303 K+ potassium transporter; Region: K_trans; cl15781 1286640003304 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 1286640003305 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286640003306 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286640003307 Walker A motif; other site 1286640003308 Walker A motif; other site 1286640003309 ATP binding site [chemical binding]; other site 1286640003310 Walker B motif; other site 1286640003311 KaiC; Region: KaiC; pfam06745 1286640003312 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 1286640003313 Walker A motif; other site 1286640003314 ATP binding site [chemical binding]; other site 1286640003315 Walker B motif; other site 1286640003316 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1286640003317 HWE histidine kinase; Region: HWE_HK; pfam07536 1286640003318 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1286640003319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640003320 active site 1286640003321 phosphorylation site [posttranslational modification] 1286640003322 intermolecular recognition site; other site 1286640003323 dimerization interface [polypeptide binding]; other site 1286640003324 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1286640003325 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1286640003326 Walker A/P-loop; other site 1286640003327 ATP binding site [chemical binding]; other site 1286640003328 Q-loop/lid; other site 1286640003329 ABC transporter signature motif; other site 1286640003330 Walker B; other site 1286640003331 D-loop; other site 1286640003332 H-loop/switch region; other site 1286640003333 TOBE-like domain; Region: TOBE_3; pfam12857 1286640003334 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1286640003335 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1286640003336 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1286640003337 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1286640003338 Flavin binding site [chemical binding]; other site 1286640003339 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640003340 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 1286640003341 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640003342 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640003343 active site 1286640003344 catalytic tetrad [active] 1286640003345 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1286640003346 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640003347 Walker A/P-loop; other site 1286640003348 ATP binding site [chemical binding]; other site 1286640003349 Q-loop/lid; other site 1286640003350 ABC transporter signature motif; other site 1286640003351 Walker B; other site 1286640003352 D-loop; other site 1286640003353 H-loop/switch region; other site 1286640003354 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286640003355 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286640003356 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640003357 Walker A/P-loop; other site 1286640003358 ATP binding site [chemical binding]; other site 1286640003359 Q-loop/lid; other site 1286640003360 ABC transporter signature motif; other site 1286640003361 Walker B; other site 1286640003362 D-loop; other site 1286640003363 H-loop/switch region; other site 1286640003364 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640003365 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286640003366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640003367 dimer interface [polypeptide binding]; other site 1286640003368 conserved gate region; other site 1286640003369 putative PBP binding loops; other site 1286640003370 ABC-ATPase subunit interface; other site 1286640003371 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640003372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640003373 dimer interface [polypeptide binding]; other site 1286640003374 conserved gate region; other site 1286640003375 putative PBP binding loops; other site 1286640003376 ABC-ATPase subunit interface; other site 1286640003377 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1286640003378 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1286640003379 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286640003380 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1286640003381 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286640003382 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1286640003383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640003384 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1286640003385 NAD(P) binding site [chemical binding]; other site 1286640003386 active site 1286640003387 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1286640003388 hypothetical protein; Provisional; Region: PRK07236 1286640003389 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1286640003390 Putative NADH-flavin reductase [General function prediction only]; Region: COG2910 1286640003391 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1286640003392 NAD(P) binding site [chemical binding]; other site 1286640003393 active site 1286640003394 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1286640003395 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1286640003396 active site 1286640003397 non-prolyl cis peptide bond; other site 1286640003398 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1286640003399 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1286640003400 Moco binding site; other site 1286640003401 metal coordination site [ion binding]; other site 1286640003402 dimerization interface [polypeptide binding]; other site 1286640003403 Fic family protein [Function unknown]; Region: COG3177 1286640003404 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1286640003405 Fic/DOC family; Region: Fic; pfam02661 1286640003406 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1286640003407 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640003408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640003409 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640003410 putative effector binding pocket; other site 1286640003411 dimerization interface [polypeptide binding]; other site 1286640003412 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1286640003413 NmrA-like family; Region: NmrA; pfam05368 1286640003414 NADP binding site [chemical binding]; other site 1286640003415 active site 1286640003416 regulatory binding site [polypeptide binding]; other site 1286640003417 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1286640003418 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1286640003419 substrate binding site [chemical binding]; other site 1286640003420 catalytic Zn binding site [ion binding]; other site 1286640003421 NAD binding site [chemical binding]; other site 1286640003422 structural Zn binding site [ion binding]; other site 1286640003423 dimer interface [polypeptide binding]; other site 1286640003424 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640003425 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1286640003426 putative C-terminal domain interface [polypeptide binding]; other site 1286640003427 putative GSH binding site (G-site) [chemical binding]; other site 1286640003428 putative dimer interface [polypeptide binding]; other site 1286640003429 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1286640003430 putative N-terminal domain interface [polypeptide binding]; other site 1286640003431 putative dimer interface [polypeptide binding]; other site 1286640003432 putative substrate binding pocket (H-site) [chemical binding]; other site 1286640003433 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1286640003434 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1286640003435 [2Fe-2S] cluster binding site [ion binding]; other site 1286640003436 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1286640003437 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1286640003438 FMN-binding pocket [chemical binding]; other site 1286640003439 flavin binding motif; other site 1286640003440 phosphate binding motif [ion binding]; other site 1286640003441 beta-alpha-beta structure motif; other site 1286640003442 NAD binding pocket [chemical binding]; other site 1286640003443 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640003444 catalytic loop [active] 1286640003445 iron binding site [ion binding]; other site 1286640003446 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1286640003447 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1286640003448 hydrophobic ligand binding site; other site 1286640003449 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1286640003450 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1286640003451 hydrophobic ligand binding site; other site 1286640003452 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640003453 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1286640003454 TM-ABC transporter signature motif; other site 1286640003455 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640003456 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1286640003457 TM-ABC transporter signature motif; other site 1286640003458 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1286640003459 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640003460 Walker A/P-loop; other site 1286640003461 ATP binding site [chemical binding]; other site 1286640003462 Q-loop/lid; other site 1286640003463 ABC transporter signature motif; other site 1286640003464 Walker B; other site 1286640003465 D-loop; other site 1286640003466 H-loop/switch region; other site 1286640003467 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640003468 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1286640003469 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1286640003470 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1286640003471 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1286640003472 hydrophobic ligand binding site; other site 1286640003473 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640003474 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640003475 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640003476 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1286640003477 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1286640003478 dimer interface [polypeptide binding]; other site 1286640003479 active site 1286640003480 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1286640003481 folate binding site [chemical binding]; other site 1286640003482 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1286640003483 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1286640003484 dimerization interface [polypeptide binding]; other site 1286640003485 ligand binding site [chemical binding]; other site 1286640003486 NADP binding site [chemical binding]; other site 1286640003487 catalytic site [active] 1286640003488 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1286640003489 homodimer interface [polypeptide binding]; other site 1286640003490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640003491 catalytic residue [active] 1286640003492 Formyltetrahydrofolate hydrolase [Nucleotide transport and metabolism]; Region: PurU; COG0788 1286640003493 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1286640003494 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1286640003495 putative active site [active] 1286640003496 putative substrate binding site [chemical binding]; other site 1286640003497 putative cosubstrate binding site; other site 1286640003498 catalytic site [active] 1286640003499 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1286640003500 FAD binding site [chemical binding]; other site 1286640003501 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1286640003502 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1286640003503 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1286640003504 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1286640003505 Predicted transcriptional regulator [Transcription]; Region: COG2944 1286640003506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640003507 non-specific DNA binding site [nucleotide binding]; other site 1286640003508 salt bridge; other site 1286640003509 sequence-specific DNA binding site [nucleotide binding]; other site 1286640003510 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640003511 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640003512 active site 1286640003513 catalytic tetrad [active] 1286640003514 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1286640003515 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1286640003516 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640003517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640003518 short chain dehydrogenase; Provisional; Region: PRK06500 1286640003519 classical (c) SDRs; Region: SDR_c; cd05233 1286640003520 NAD(P) binding site [chemical binding]; other site 1286640003521 active site 1286640003522 Predicted transcriptional regulator [Transcription]; Region: COG4190 1286640003523 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640003524 dimerization interface [polypeptide binding]; other site 1286640003525 putative DNA binding site [nucleotide binding]; other site 1286640003526 putative Zn2+ binding site [ion binding]; other site 1286640003527 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 1286640003528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1286640003529 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1286640003530 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1286640003531 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1286640003532 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1286640003533 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1286640003534 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1286640003535 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 1286640003536 Int/Topo IB signature motif; other site 1286640003537 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 1286640003538 Int/Topo IB signature motif; other site 1286640003539 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1286640003540 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1286640003541 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1286640003542 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286640003543 active site 1286640003544 DNA binding site [nucleotide binding] 1286640003545 Int/Topo IB signature motif; other site 1286640003546 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640003547 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640003548 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286640003549 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286640003550 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286640003551 Walker A/P-loop; other site 1286640003552 ATP binding site [chemical binding]; other site 1286640003553 Q-loop/lid; other site 1286640003554 ABC transporter signature motif; other site 1286640003555 Walker B; other site 1286640003556 D-loop; other site 1286640003557 H-loop/switch region; other site 1286640003558 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640003559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640003560 dimer interface [polypeptide binding]; other site 1286640003561 conserved gate region; other site 1286640003562 putative PBP binding loops; other site 1286640003563 ABC-ATPase subunit interface; other site 1286640003564 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640003565 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286640003566 substrate binding pocket [chemical binding]; other site 1286640003567 membrane-bound complex binding site; other site 1286640003568 hinge residues; other site 1286640003569 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1286640003570 homotrimer interaction site [polypeptide binding]; other site 1286640003571 putative active site [active] 1286640003572 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640003573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640003574 putative PBP binding loops; other site 1286640003575 ABC-ATPase subunit interface; other site 1286640003576 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286640003577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640003578 dimer interface [polypeptide binding]; other site 1286640003579 conserved gate region; other site 1286640003580 putative PBP binding loops; other site 1286640003581 ABC-ATPase subunit interface; other site 1286640003582 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286640003583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640003584 Walker A/P-loop; other site 1286640003585 ATP binding site [chemical binding]; other site 1286640003586 Q-loop/lid; other site 1286640003587 ABC transporter signature motif; other site 1286640003588 Walker B; other site 1286640003589 D-loop; other site 1286640003590 H-loop/switch region; other site 1286640003591 TOBE domain; Region: TOBE; pfam03459 1286640003592 TOBE domain; Region: TOBE_2; pfam08402 1286640003593 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1286640003594 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286640003595 thiamine pyrophosphate protein; Validated; Region: PRK08199 1286640003596 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286640003597 PYR/PP interface [polypeptide binding]; other site 1286640003598 dimer interface [polypeptide binding]; other site 1286640003599 TPP binding site [chemical binding]; other site 1286640003600 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286640003601 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1286640003602 TPP-binding site [chemical binding]; other site 1286640003603 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286640003604 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1286640003605 NAD(P) binding site [chemical binding]; other site 1286640003606 catalytic residues [active] 1286640003607 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1286640003608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640003609 DNA-binding site [nucleotide binding]; DNA binding site 1286640003610 UTRA domain; Region: UTRA; pfam07702 1286640003611 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1286640003612 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1286640003613 Flavoprotein; Region: Flavoprotein; pfam02441 1286640003614 hypothetical protein; Provisional; Region: PRK07475 1286640003615 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640003616 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640003617 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1286640003618 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1286640003619 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1286640003620 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1286640003621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640003622 DNA-binding site [nucleotide binding]; DNA binding site 1286640003623 UTRA domain; Region: UTRA; pfam07702 1286640003624 Protein of unknown function (DUF2390); Region: DUF2390; cl02376 1286640003625 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1286640003626 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1286640003627 Bacteriophage protein gp37 [Function unknown]; Region: COG4422 1286640003628 Superfamily II helicase [General function prediction only]; Region: COG1204 1286640003629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286640003630 ATP binding site [chemical binding]; other site 1286640003631 putative Mg++ binding site [ion binding]; other site 1286640003632 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1286640003633 Protein of unknown function (DUF904); Region: DUF904; pfam06005 1286640003634 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1286640003635 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1286640003636 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1286640003637 putative active site [active] 1286640003638 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286640003639 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1286640003640 active site 1286640003641 DNA binding site [nucleotide binding] 1286640003642 Int/Topo IB signature motif; other site 1286640003643 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1286640003644 putative dimer interface [polypeptide binding]; other site 1286640003645 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640003646 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1286640003647 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1286640003648 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1286640003649 Uncharacterized conserved protein [Function unknown]; Region: COG5654 1286640003650 Uncharacterized conserved protein [Function unknown]; Region: COG5642 1286640003651 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286640003652 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286640003653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640003654 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1286640003655 dimerization interface [polypeptide binding]; other site 1286640003656 substrate binding pocket [chemical binding]; other site 1286640003657 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286640003658 homotrimer interaction site [polypeptide binding]; other site 1286640003659 putative active site [active] 1286640003660 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1286640003661 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1286640003662 active site 1286640003663 FMN binding site [chemical binding]; other site 1286640003664 substrate binding site [chemical binding]; other site 1286640003665 putative catalytic residue [active] 1286640003666 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286640003667 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640003668 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640003669 dimerization interface [polypeptide binding]; other site 1286640003670 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1286640003671 Transglycosylase; Region: Transgly; pfam00912 1286640003672 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286640003673 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1286640003674 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286640003675 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286640003676 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1286640003677 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286640003678 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286640003679 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640003680 metal binding site [ion binding]; metal-binding site 1286640003681 active site 1286640003682 I-site; other site 1286640003683 non-specific DNA interactions [nucleotide binding]; other site 1286640003684 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1286640003685 DNA binding site [nucleotide binding] 1286640003686 sequence specific DNA binding site [nucleotide binding]; other site 1286640003687 putative cAMP binding site [chemical binding]; other site 1286640003688 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286640003689 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286640003690 nucleotide binding site [chemical binding]; other site 1286640003691 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286640003692 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640003693 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640003694 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1286640003695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640003696 dimer interface [polypeptide binding]; other site 1286640003697 conserved gate region; other site 1286640003698 putative PBP binding loops; other site 1286640003699 ABC-ATPase subunit interface; other site 1286640003700 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640003701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640003702 dimer interface [polypeptide binding]; other site 1286640003703 conserved gate region; other site 1286640003704 putative PBP binding loops; other site 1286640003705 ABC-ATPase subunit interface; other site 1286640003706 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286640003707 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640003708 Walker A/P-loop; other site 1286640003709 ATP binding site [chemical binding]; other site 1286640003710 Q-loop/lid; other site 1286640003711 ABC transporter signature motif; other site 1286640003712 Walker B; other site 1286640003713 D-loop; other site 1286640003714 H-loop/switch region; other site 1286640003715 TOBE domain; Region: TOBE_2; pfam08402 1286640003716 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640003717 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640003718 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286640003719 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640003720 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640003721 active site 1286640003722 catalytic tetrad [active] 1286640003723 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1286640003724 active site 1286640003725 NTP binding site [chemical binding]; other site 1286640003726 metal binding triad [ion binding]; metal-binding site 1286640003727 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1286640003728 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1286640003729 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1286640003730 putative C-terminal domain interface [polypeptide binding]; other site 1286640003731 putative GSH binding site (G-site) [chemical binding]; other site 1286640003732 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640003733 putative dimer interface [polypeptide binding]; other site 1286640003734 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1286640003735 dimer interface [polypeptide binding]; other site 1286640003736 N-terminal domain interface [polypeptide binding]; other site 1286640003737 putative substrate binding pocket (H-site) [chemical binding]; other site 1286640003738 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1286640003739 Part of AAA domain; Region: AAA_19; pfam13245 1286640003740 Family description; Region: UvrD_C_2; pfam13538 1286640003741 Ion channel; Region: Ion_trans_2; pfam07885 1286640003742 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640003743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640003744 active site 1286640003745 phosphorylation site [posttranslational modification] 1286640003746 intermolecular recognition site; other site 1286640003747 dimerization interface [polypeptide binding]; other site 1286640003748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640003749 DNA binding site [nucleotide binding] 1286640003750 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1286640003751 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1286640003752 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1286640003753 Ligand Binding Site [chemical binding]; other site 1286640003754 GAF domain; Region: GAF_3; pfam13492 1286640003755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640003756 dimer interface [polypeptide binding]; other site 1286640003757 phosphorylation site [posttranslational modification] 1286640003758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640003759 ATP binding site [chemical binding]; other site 1286640003760 Mg2+ binding site [ion binding]; other site 1286640003761 G-X-G motif; other site 1286640003762 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1286640003763 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1286640003764 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286640003765 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1286640003766 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1286640003767 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 1286640003768 muropeptide transporter; Validated; Region: ampG; cl17669 1286640003769 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 1286640003770 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640003771 inhibitor-cofactor binding pocket; inhibition site 1286640003772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640003773 catalytic residue [active] 1286640003774 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1286640003775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640003776 catalytic residue [active] 1286640003777 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1286640003778 IucA / IucC family; Region: IucA_IucC; pfam04183 1286640003779 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1286640003780 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1286640003781 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1286640003782 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1286640003783 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286640003784 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1286640003785 IucA / IucC family; Region: IucA_IucC; pfam04183 1286640003786 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1286640003787 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640003788 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640003789 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1286640003790 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286640003791 N-terminal plug; other site 1286640003792 ligand-binding site [chemical binding]; other site 1286640003793 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1286640003794 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1286640003795 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640003796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640003797 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1286640003798 putative effector binding pocket; other site 1286640003799 putative dimerization interface [polypeptide binding]; other site 1286640003800 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1286640003801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640003802 NAD(P) binding site [chemical binding]; other site 1286640003803 active site 1286640003804 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1286640003805 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 1286640003806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640003807 S-adenosylmethionine binding site [chemical binding]; other site 1286640003808 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 1286640003809 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640003810 catalytic loop [active] 1286640003811 iron binding site [ion binding]; other site 1286640003812 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1286640003813 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1286640003814 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1286640003815 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1286640003816 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1286640003817 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640003818 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1286640003819 active site 1286640003820 DNA polymerase IV; Validated; Region: PRK02406 1286640003821 DNA binding site [nucleotide binding] 1286640003822 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640003823 cyclase homology domain; Region: CHD; cd07302 1286640003824 nucleotidyl binding site; other site 1286640003825 metal binding site [ion binding]; metal-binding site 1286640003826 dimer interface [polypeptide binding]; other site 1286640003827 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286640003828 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1286640003829 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1286640003830 putative ligand binding site [chemical binding]; other site 1286640003831 amidase; Provisional; Region: PRK07869 1286640003832 Amidase; Region: Amidase; cl11426 1286640003833 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1286640003834 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640003835 Walker A/P-loop; other site 1286640003836 ATP binding site [chemical binding]; other site 1286640003837 Q-loop/lid; other site 1286640003838 ABC transporter signature motif; other site 1286640003839 Walker B; other site 1286640003840 D-loop; other site 1286640003841 H-loop/switch region; other site 1286640003842 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640003843 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640003844 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1286640003845 TM-ABC transporter signature motif; other site 1286640003846 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640003847 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1286640003848 TM-ABC transporter signature motif; other site 1286640003849 cytosine deaminase; Validated; Region: PRK07572 1286640003850 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1286640003851 active site 1286640003852 Transcriptional activator [Transcription]; Region: ChrR; COG3806 1286640003853 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1286640003854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1286640003855 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640003856 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640003857 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1286640003858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1286640003859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640003860 putative substrate translocation pore; other site 1286640003861 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1286640003862 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1286640003863 dimer interface [polypeptide binding]; other site 1286640003864 active site 1286640003865 heme binding site [chemical binding]; other site 1286640003866 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1286640003867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640003868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640003869 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286640003870 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1286640003871 NADP binding site [chemical binding]; other site 1286640003872 dimer interface [polypeptide binding]; other site 1286640003873 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1286640003874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640003875 Walker A/P-loop; other site 1286640003876 ATP binding site [chemical binding]; other site 1286640003877 Q-loop/lid; other site 1286640003878 ABC transporter signature motif; other site 1286640003879 Walker B; other site 1286640003880 D-loop; other site 1286640003881 H-loop/switch region; other site 1286640003882 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286640003883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640003884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640003885 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1286640003886 replication initiation protein RepC; Provisional; Region: PRK13824 1286640003887 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1286640003888 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1286640003889 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 1286640003890 ParB-like nuclease domain; Region: ParB; smart00470 1286640003891 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 1286640003892 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1286640003893 P-loop; other site 1286640003894 Magnesium ion binding site [ion binding]; other site 1286640003895 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1286640003896 Magnesium ion binding site [ion binding]; other site 1286640003897 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1286640003898 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1286640003899 active site 1286640003900 dimer interface [polypeptide binding]; other site 1286640003901 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1286640003902 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1286640003903 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1286640003904 shikimate binding site; other site 1286640003905 NAD(P) binding site [chemical binding]; other site 1286640003906 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1286640003907 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1286640003908 CoA-binding site [chemical binding]; other site 1286640003909 ATP-binding [chemical binding]; other site 1286640003910 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1286640003911 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1286640003912 active site 1286640003913 catalytic site [active] 1286640003914 substrate binding site [chemical binding]; other site 1286640003915 Preprotein translocase subunit SecB [Intracellular trafficking and secretion]; Region: SecB; COG1952 1286640003916 SecA binding site; other site 1286640003917 Preprotein binding site; other site 1286640003918 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1286640003919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1286640003920 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1286640003921 MltA specific insert domain; Region: MltA; pfam03562 1286640003922 3D domain; Region: 3D; pfam06725 1286640003923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1286640003924 Smr domain; Region: Smr; pfam01713 1286640003925 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286640003926 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640003927 non-specific DNA binding site [nucleotide binding]; other site 1286640003928 salt bridge; other site 1286640003929 sequence-specific DNA binding site [nucleotide binding]; other site 1286640003930 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1286640003931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640003932 Mg2+ binding site [ion binding]; other site 1286640003933 G-X-G motif; other site 1286640003934 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1286640003935 anchoring element; other site 1286640003936 dimer interface [polypeptide binding]; other site 1286640003937 ATP binding site [chemical binding]; other site 1286640003938 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1286640003939 active site 1286640003940 putative metal-binding site [ion binding]; other site 1286640003941 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1286640003942 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1286640003943 putative FMN binding site [chemical binding]; other site 1286640003944 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1286640003945 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1286640003946 tetramerization interface [polypeptide binding]; other site 1286640003947 NAD(P) binding site [chemical binding]; other site 1286640003948 catalytic residues [active] 1286640003949 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286640003950 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286640003951 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286640003952 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1286640003953 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1286640003954 DNA-binding site [nucleotide binding]; DNA binding site 1286640003955 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640003956 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1286640003957 DNA-binding site [nucleotide binding]; DNA binding site 1286640003958 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286640003959 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1286640003960 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1286640003961 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1286640003962 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640003963 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640003964 active site 1286640003965 catalytic tetrad [active] 1286640003966 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1286640003967 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286640003968 putative ligand binding site [chemical binding]; other site 1286640003969 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640003970 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640003971 Walker A/P-loop; other site 1286640003972 ATP binding site [chemical binding]; other site 1286640003973 Q-loop/lid; other site 1286640003974 ABC transporter signature motif; other site 1286640003975 Walker B; other site 1286640003976 D-loop; other site 1286640003977 H-loop/switch region; other site 1286640003978 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640003979 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640003980 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640003981 TM-ABC transporter signature motif; other site 1286640003982 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286640003983 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1286640003984 putative NAD(P) binding site [chemical binding]; other site 1286640003985 catalytic Zn binding site [ion binding]; other site 1286640003986 structural Zn binding site [ion binding]; other site 1286640003987 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 1286640003988 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1286640003989 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 1286640003990 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1286640003991 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1286640003992 active site 1286640003993 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1286640003994 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1286640003995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640003996 catalytic residue [active] 1286640003997 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1286640003998 substrate binding site [chemical binding]; other site 1286640003999 active site 1286640004000 catalytic residues [active] 1286640004001 heterodimer interface [polypeptide binding]; other site 1286640004002 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1286640004003 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1286640004004 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1286640004005 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286640004006 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1286640004007 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1286640004008 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286640004009 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1286640004010 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286640004011 catalytic residues [active] 1286640004012 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 1286640004013 Family description; Region: UvrD_C_2; pfam13538 1286640004014 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1286640004015 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 1286640004016 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1286640004017 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1286640004018 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1286640004019 Substrate binding site; other site 1286640004020 metal-binding site 1286640004021 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1286640004022 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1286640004023 Phosphotransferase enzyme family; Region: APH; pfam01636 1286640004024 PAS fold; Region: PAS_7; pfam12860 1286640004025 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1286640004026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640004027 dimer interface [polypeptide binding]; other site 1286640004028 phosphorylation site [posttranslational modification] 1286640004029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640004030 ATP binding site [chemical binding]; other site 1286640004031 Mg2+ binding site [ion binding]; other site 1286640004032 G-X-G motif; other site 1286640004033 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1286640004034 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1286640004035 homotetramer interface [polypeptide binding]; other site 1286640004036 ligand binding site [chemical binding]; other site 1286640004037 catalytic site [active] 1286640004038 NAD binding site [chemical binding]; other site 1286640004039 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1286640004040 dimerization domain swap beta strand [polypeptide binding]; other site 1286640004041 regulatory protein interface [polypeptide binding]; other site 1286640004042 active site 1286640004043 regulatory phosphorylation site [posttranslational modification]; other site 1286640004044 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1286640004045 active pocket/dimerization site; other site 1286640004046 active site 1286640004047 phosphorylation site [posttranslational modification] 1286640004048 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 1286640004049 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1286640004050 Hpr binding site; other site 1286640004051 active site 1286640004052 homohexamer subunit interaction site [polypeptide binding]; other site 1286640004053 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 1286640004054 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 1286640004055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640004056 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1286640004057 dimerization interface [polypeptide binding]; other site 1286640004058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640004059 dimer interface [polypeptide binding]; other site 1286640004060 phosphorylation site [posttranslational modification] 1286640004061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640004062 ATP binding site [chemical binding]; other site 1286640004063 Mg2+ binding site [ion binding]; other site 1286640004064 G-X-G motif; other site 1286640004065 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640004066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640004067 active site 1286640004068 phosphorylation site [posttranslational modification] 1286640004069 intermolecular recognition site; other site 1286640004070 dimerization interface [polypeptide binding]; other site 1286640004071 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640004072 DNA binding site [nucleotide binding] 1286640004073 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1286640004074 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1286640004075 active site 1286640004076 substrate-binding site [chemical binding]; other site 1286640004077 metal-binding site [ion binding] 1286640004078 ATP binding site [chemical binding]; other site 1286640004079 hypothetical protein; Provisional; Region: PRK09256 1286640004080 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1286640004081 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1286640004082 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286640004083 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1286640004084 pantothenate kinase; Provisional; Region: PRK05439 1286640004085 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1286640004086 ATP-binding site [chemical binding]; other site 1286640004087 CoA-binding site [chemical binding]; other site 1286640004088 Mg2+-binding site [ion binding]; other site 1286640004089 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1286640004090 metal binding site [ion binding]; metal-binding site 1286640004091 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1286640004092 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1286640004093 substrate binding site [chemical binding]; other site 1286640004094 glutamase interaction surface [polypeptide binding]; other site 1286640004095 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1286640004096 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1286640004097 catalytic residues [active] 1286640004098 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1286640004099 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1286640004100 putative active site [active] 1286640004101 oxyanion strand; other site 1286640004102 catalytic triad [active] 1286640004103 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1286640004104 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1286640004105 putative active site pocket [active] 1286640004106 4-fold oligomerization interface [polypeptide binding]; other site 1286640004107 metal binding residues [ion binding]; metal-binding site 1286640004108 3-fold/trimer interface [polypeptide binding]; other site 1286640004109 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1286640004110 active site 1286640004111 HslU subunit interaction site [polypeptide binding]; other site 1286640004112 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1286640004113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1286640004114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286640004115 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1286640004116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640004117 Walker A motif; other site 1286640004118 ATP binding site [chemical binding]; other site 1286640004119 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1286640004120 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1286640004121 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 1286640004122 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1286640004123 Cytochrome P450; Region: p450; cl12078 1286640004124 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1286640004125 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1286640004126 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1286640004127 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1286640004128 active site 1286640004129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1286640004130 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286640004131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5321 1286640004132 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1286640004133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640004134 active site 1286640004135 phosphorylation site [posttranslational modification] 1286640004136 intermolecular recognition site; other site 1286640004137 dimerization interface [polypeptide binding]; other site 1286640004138 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1286640004139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640004140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640004141 dimer interface [polypeptide binding]; other site 1286640004142 phosphorylation site [posttranslational modification] 1286640004143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640004144 ATP binding site [chemical binding]; other site 1286640004145 Mg2+ binding site [ion binding]; other site 1286640004146 G-X-G motif; other site 1286640004147 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1286640004148 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286640004149 ATP binding site [chemical binding]; other site 1286640004150 putative Mg++ binding site [ion binding]; other site 1286640004151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286640004152 nucleotide binding region [chemical binding]; other site 1286640004153 ATP-binding site [chemical binding]; other site 1286640004154 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1286640004155 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1286640004156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640004157 Walker A/P-loop; other site 1286640004158 ATP binding site [chemical binding]; other site 1286640004159 Q-loop/lid; other site 1286640004160 ABC transporter signature motif; other site 1286640004161 Walker B; other site 1286640004162 D-loop; other site 1286640004163 H-loop/switch region; other site 1286640004164 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 1286640004165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640004166 dimer interface [polypeptide binding]; other site 1286640004167 conserved gate region; other site 1286640004168 putative PBP binding loops; other site 1286640004169 ABC-ATPase subunit interface; other site 1286640004170 hypothetical protein; Provisional; Region: PRK11622 1286640004171 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1286640004172 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1286640004173 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1286640004174 O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080 1286640004175 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286640004176 homodimer interface [polypeptide binding]; other site 1286640004177 substrate-cofactor binding pocket; other site 1286640004178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640004179 catalytic residue [active] 1286640004180 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640004181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640004182 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1286640004183 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1286640004184 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 1286640004185 HPP family; Region: HPP; pfam04982 1286640004186 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1286640004187 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 1286640004188 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 1286640004189 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1286640004190 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1286640004191 homodimer interface [polypeptide binding]; other site 1286640004192 NADP binding site [chemical binding]; other site 1286640004193 substrate binding site [chemical binding]; other site 1286640004194 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 1286640004195 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1286640004196 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1286640004197 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1286640004198 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 1286640004199 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1286640004200 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640004201 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1286640004202 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1286640004203 conserved cys residue [active] 1286640004204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640004205 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1286640004206 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1286640004207 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 1286640004208 putative active site [active] 1286640004209 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 1286640004210 domain_subunit interface; other site 1286640004211 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1286640004212 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1286640004213 active site 1286640004214 FMN binding site [chemical binding]; other site 1286640004215 substrate binding site [chemical binding]; other site 1286640004216 3Fe-4S cluster binding site [ion binding]; other site 1286640004217 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 1286640004218 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1286640004219 ethanolamine permease; Region: 2A0305; TIGR00908 1286640004220 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1286640004221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640004222 non-specific DNA binding site [nucleotide binding]; other site 1286640004223 salt bridge; other site 1286640004224 sequence-specific DNA binding site [nucleotide binding]; other site 1286640004225 Cupin domain; Region: Cupin_2; pfam07883 1286640004226 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1286640004227 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1286640004228 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1286640004229 putative active site [active] 1286640004230 putative substrate binding site [chemical binding]; other site 1286640004231 putative cosubstrate binding site; other site 1286640004232 catalytic site [active] 1286640004233 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1286640004234 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1286640004235 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1286640004236 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1286640004237 FMN-binding pocket [chemical binding]; other site 1286640004238 flavin binding motif; other site 1286640004239 phosphate binding motif [ion binding]; other site 1286640004240 beta-alpha-beta structure motif; other site 1286640004241 NAD binding pocket [chemical binding]; other site 1286640004242 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640004243 catalytic loop [active] 1286640004244 iron binding site [ion binding]; other site 1286640004245 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 1286640004246 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1286640004247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286640004248 Uncharacterized conserved protein [Function unknown]; Region: COG3665 1286640004249 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1286640004250 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1286640004251 Amino acid permease; Region: AA_permease_2; pfam13520 1286640004252 putative phosphoketolase; Provisional; Region: PRK05261 1286640004253 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1286640004254 TPP-binding site; other site 1286640004255 XFP C-terminal domain; Region: XFP_C; pfam09363 1286640004256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640004257 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1286640004258 NAD(P) binding site [chemical binding]; other site 1286640004259 active site 1286640004260 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 1286640004261 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640004262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640004263 DNA-binding site [nucleotide binding]; DNA binding site 1286640004264 FCD domain; Region: FCD; pfam07729 1286640004265 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1286640004266 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640004267 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1286640004268 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1286640004269 N-terminal domain interface [polypeptide binding]; other site 1286640004270 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640004271 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640004272 Walker A/P-loop; other site 1286640004273 ATP binding site [chemical binding]; other site 1286640004274 Q-loop/lid; other site 1286640004275 ABC transporter signature motif; other site 1286640004276 Walker B; other site 1286640004277 D-loop; other site 1286640004278 H-loop/switch region; other site 1286640004279 TOBE domain; Region: TOBE_2; pfam08402 1286640004280 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640004281 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640004282 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286640004283 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640004284 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640004285 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286640004286 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640004287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640004288 dimer interface [polypeptide binding]; other site 1286640004289 conserved gate region; other site 1286640004290 putative PBP binding loops; other site 1286640004291 ABC-ATPase subunit interface; other site 1286640004292 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1286640004293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640004294 dimer interface [polypeptide binding]; other site 1286640004295 conserved gate region; other site 1286640004296 putative PBP binding loops; other site 1286640004297 ABC-ATPase subunit interface; other site 1286640004298 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640004299 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640004300 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1286640004301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640004302 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640004303 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640004304 Protein of unknown function (DUF993); Region: DUF993; pfam06187 1286640004305 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1286640004306 metal binding site [ion binding]; metal-binding site 1286640004307 substrate binding pocket [chemical binding]; other site 1286640004308 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286640004309 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1286640004310 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640004311 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640004312 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286640004313 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286640004314 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1286640004315 metal-binding site [ion binding] 1286640004316 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286640004317 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1286640004318 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640004319 Walker A/P-loop; other site 1286640004320 ATP binding site [chemical binding]; other site 1286640004321 Q-loop/lid; other site 1286640004322 ABC transporter signature motif; other site 1286640004323 Walker B; other site 1286640004324 D-loop; other site 1286640004325 H-loop/switch region; other site 1286640004326 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640004327 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640004328 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1286640004329 TM-ABC transporter signature motif; other site 1286640004330 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640004331 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1286640004332 TM-ABC transporter signature motif; other site 1286640004333 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1286640004334 active site 1286640004335 catalytic motif [active] 1286640004336 Zn binding site [ion binding]; other site 1286640004337 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1286640004338 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 1286640004339 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1286640004340 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1286640004341 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1286640004342 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286640004343 active site 1286640004344 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1286640004345 adenosine deaminase; Provisional; Region: PRK09358 1286640004346 active site 1286640004347 phosphopentomutase; Provisional; Region: PRK05362 1286640004348 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1286640004349 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1286640004350 TadE-like protein; Region: TadE; pfam07811 1286640004351 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1286640004352 TadE-like protein; Region: TadE; pfam07811 1286640004353 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1286640004354 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1286640004355 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286640004356 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1286640004357 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1286640004358 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 1286640004359 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1286640004360 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1286640004361 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1286640004362 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1286640004363 BON domain; Region: BON; pfam04972 1286640004364 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1286640004365 Type IV pili component [Cell motility and secretion]; Region: COG5461 1286640004366 pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522 1286640004367 AAA domain; Region: AAA_31; pfam13614 1286640004368 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1286640004369 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1286640004370 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1286640004371 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1286640004372 ATP binding site [chemical binding]; other site 1286640004373 Walker A motif; other site 1286640004374 hexamer interface [polypeptide binding]; other site 1286640004375 Walker B motif; other site 1286640004376 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1286640004377 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1286640004378 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1286640004379 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1286640004380 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1286640004381 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1286640004382 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286640004383 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 1286640004384 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640004385 TPR motif; other site 1286640004386 binding surface 1286640004387 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1286640004388 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1286640004389 interface (dimer of trimers) [polypeptide binding]; other site 1286640004390 Substrate-binding/catalytic site; other site 1286640004391 Zn-binding sites [ion binding]; other site 1286640004392 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286640004393 MarR family; Region: MarR; pfam01047 1286640004394 Bacterial SH3 domain; Region: SH3_3; cl17532 1286640004395 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1286640004396 NlpC/P60 family; Region: NLPC_P60; cl17555 1286640004397 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1286640004398 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1286640004399 putative ligand binding site [chemical binding]; other site 1286640004400 NAD binding site [chemical binding]; other site 1286640004401 dimerization interface [polypeptide binding]; other site 1286640004402 catalytic site [active] 1286640004403 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1286640004404 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640004405 Walker A/P-loop; other site 1286640004406 ATP binding site [chemical binding]; other site 1286640004407 Q-loop/lid; other site 1286640004408 ABC transporter signature motif; other site 1286640004409 Walker B; other site 1286640004410 D-loop; other site 1286640004411 H-loop/switch region; other site 1286640004412 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1286640004413 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640004414 Walker A/P-loop; other site 1286640004415 ATP binding site [chemical binding]; other site 1286640004416 Q-loop/lid; other site 1286640004417 ABC transporter signature motif; other site 1286640004418 Walker B; other site 1286640004419 D-loop; other site 1286640004420 H-loop/switch region; other site 1286640004421 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640004422 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1286640004423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640004424 dimer interface [polypeptide binding]; other site 1286640004425 conserved gate region; other site 1286640004426 putative PBP binding loops; other site 1286640004427 ABC-ATPase subunit interface; other site 1286640004428 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1286640004429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640004430 dimer interface [polypeptide binding]; other site 1286640004431 conserved gate region; other site 1286640004432 putative PBP binding loops; other site 1286640004433 ABC-ATPase subunit interface; other site 1286640004434 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286640004435 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1286640004436 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1286640004437 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1286640004438 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1286640004439 active site 1286640004440 dimer interfaces [polypeptide binding]; other site 1286640004441 catalytic residues [active] 1286640004442 glucokinase; Provisional; Region: glk; PRK00292 1286640004443 glucokinase, proteobacterial type; Region: glk; TIGR00749 1286640004444 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286640004445 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640004446 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1286640004447 Walker A/P-loop; other site 1286640004448 ATP binding site [chemical binding]; other site 1286640004449 Q-loop/lid; other site 1286640004450 ABC transporter signature motif; other site 1286640004451 Walker B; other site 1286640004452 D-loop; other site 1286640004453 H-loop/switch region; other site 1286640004454 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1286640004455 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1286640004456 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1286640004457 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286640004458 catalytic core [active] 1286640004459 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1286640004460 MULE transposase domain; Region: MULE; pfam10551 1286640004461 Helix-turn-helix domain; Region: HTH_18; pfam12833 1286640004462 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1286640004463 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1286640004464 DNA binding site [nucleotide binding] 1286640004465 active site 1286640004466 Integral membrane protein [Function unknown]; Region: COG5488 1286640004467 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1286640004468 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1286640004469 minor groove reading motif; other site 1286640004470 helix-hairpin-helix signature motif; other site 1286640004471 substrate binding pocket [chemical binding]; other site 1286640004472 active site 1286640004473 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1286640004474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640004475 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1286640004476 putative dimer interface [polypeptide binding]; other site 1286640004477 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640004478 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 1286640004479 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286640004480 substrate binding site [chemical binding]; other site 1286640004481 ATP binding site [chemical binding]; other site 1286640004482 Predicted kinase [General function prediction only]; Region: COG0645 1286640004483 AAA domain; Region: AAA_17; pfam13207 1286640004484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 1286640004485 Bacterial SH3 domain; Region: SH3_4; pfam06347 1286640004486 Bacterial SH3 domain; Region: SH3_4; pfam06347 1286640004487 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1286640004488 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1286640004489 dimerization interface [polypeptide binding]; other site 1286640004490 ligand binding site [chemical binding]; other site 1286640004491 NADP binding site [chemical binding]; other site 1286640004492 catalytic site [active] 1286640004493 5'-3' exonuclease; Region: 53EXOc; smart00475 1286640004494 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1286640004495 active site 1286640004496 metal binding site 1 [ion binding]; metal-binding site 1286640004497 putative 5' ssDNA interaction site; other site 1286640004498 metal binding site 3; metal-binding site 1286640004499 metal binding site 2 [ion binding]; metal-binding site 1286640004500 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1286640004501 putative DNA binding site [nucleotide binding]; other site 1286640004502 putative metal binding site [ion binding]; other site 1286640004503 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 1286640004504 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1286640004505 active site 1286640004506 catalytic site [active] 1286640004507 substrate binding site [chemical binding]; other site 1286640004508 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1286640004509 active site 1286640004510 DNA binding site [nucleotide binding] 1286640004511 catalytic site [active] 1286640004512 MarR family; Region: MarR; pfam01047 1286640004513 hypothetical protein; Validated; Region: PRK09104 1286640004514 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 1286640004515 metal binding site [ion binding]; metal-binding site 1286640004516 putative dimer interface [polypeptide binding]; other site 1286640004517 Predicted integral membrane protein [Function unknown]; Region: COG0392 1286640004518 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286640004519 EamA-like transporter family; Region: EamA; pfam00892 1286640004520 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1286640004521 Transglycosylase; Region: Transgly; pfam00912 1286640004522 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1286640004523 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1286640004524 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1286640004525 nucleotide binding site [chemical binding]; other site 1286640004526 NEF interaction site [polypeptide binding]; other site 1286640004527 SBD interface [polypeptide binding]; other site 1286640004528 chaperone protein DnaJ; Provisional; Region: PRK10767 1286640004529 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1286640004530 HSP70 interaction site [polypeptide binding]; other site 1286640004531 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1286640004532 substrate binding site [polypeptide binding]; other site 1286640004533 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1286640004534 Zn binding sites [ion binding]; other site 1286640004535 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1286640004536 dimer interface [polypeptide binding]; other site 1286640004537 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 1286640004538 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 1286640004539 Uncharacterized conserved protein [Function unknown]; Region: COG5588 1286640004540 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1286640004541 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 1286640004542 recombination protein F; Reviewed; Region: recF; PRK00064 1286640004543 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1286640004544 Walker A/P-loop; other site 1286640004545 ATP binding site [chemical binding]; other site 1286640004546 Q-loop/lid; other site 1286640004547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640004548 ABC transporter signature motif; other site 1286640004549 Walker B; other site 1286640004550 D-loop; other site 1286640004551 H-loop/switch region; other site 1286640004552 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1286640004553 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1286640004554 ATP binding site [chemical binding]; other site 1286640004555 substrate interface [chemical binding]; other site 1286640004556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640004557 Coenzyme A binding pocket [chemical binding]; other site 1286640004558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640004559 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1286640004560 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1286640004561 Protein export membrane protein; Region: SecD_SecF; cl14618 1286640004562 Protein export membrane protein; Region: SecD_SecF; cl14618 1286640004563 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1286640004564 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640004565 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640004566 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640004567 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640004568 Walker A/P-loop; other site 1286640004569 ATP binding site [chemical binding]; other site 1286640004570 Q-loop/lid; other site 1286640004571 ABC transporter signature motif; other site 1286640004572 Walker B; other site 1286640004573 D-loop; other site 1286640004574 H-loop/switch region; other site 1286640004575 TOBE domain; Region: TOBE_2; pfam08402 1286640004576 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640004577 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640004578 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640004579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640004580 dimer interface [polypeptide binding]; other site 1286640004581 conserved gate region; other site 1286640004582 putative PBP binding loops; other site 1286640004583 ABC-ATPase subunit interface; other site 1286640004584 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640004585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640004586 dimer interface [polypeptide binding]; other site 1286640004587 conserved gate region; other site 1286640004588 putative PBP binding loops; other site 1286640004589 ABC-ATPase subunit interface; other site 1286640004590 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640004591 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640004592 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 1286640004593 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1286640004594 putative active site [active] 1286640004595 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1286640004596 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1286640004597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640004598 DNA-binding site [nucleotide binding]; DNA binding site 1286640004599 UTRA domain; Region: UTRA; pfam07702 1286640004600 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1286640004601 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1286640004602 dimer interface [polypeptide binding]; other site 1286640004603 active site 1286640004604 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1286640004605 dimer interface [polypeptide binding]; other site 1286640004606 active site 1286640004607 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1286640004608 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1286640004609 active site 1286640004610 dimer interface [polypeptide binding]; other site 1286640004611 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1286640004612 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286640004613 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286640004614 hypothetical protein; Provisional; Region: PRK06102 1286640004615 Amidase; Region: Amidase; cl11426 1286640004616 CysZ-like protein; Reviewed; Region: PRK12768 1286640004617 hypothetical protein; Provisional; Region: PRK00736 1286640004618 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1286640004619 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1286640004620 ligand binding site [chemical binding]; other site 1286640004621 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1286640004622 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1286640004623 HicB family; Region: HicB; pfam05534 1286640004624 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1286640004625 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640004626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640004627 muropeptide transporter; Validated; Region: ampG; cl17669 1286640004628 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1286640004629 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286640004630 N-terminal plug; other site 1286640004631 ligand-binding site [chemical binding]; other site 1286640004632 hypothetical protein; Provisional; Region: PRK07588 1286640004633 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1286640004634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640004635 putative substrate translocation pore; other site 1286640004636 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286640004637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640004638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640004639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640004640 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1286640004641 putative substrate binding pocket [chemical binding]; other site 1286640004642 putative dimerization interface [polypeptide binding]; other site 1286640004643 Predicted permeases [General function prediction only]; Region: COG0679 1286640004644 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1286640004645 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1286640004646 homodimer interface [polypeptide binding]; other site 1286640004647 substrate-cofactor binding pocket; other site 1286640004648 catalytic residue [active] 1286640004649 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1286640004650 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1286640004651 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1286640004652 Ligand binding site; other site 1286640004653 oligomer interface; other site 1286640004654 prephenate dehydratase; Provisional; Region: PRK11899 1286640004655 Prephenate dehydratase; Region: PDT; pfam00800 1286640004656 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1286640004657 putative L-Phe binding site [chemical binding]; other site 1286640004658 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1286640004659 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 1286640004660 putative dimer interface [polypeptide binding]; other site 1286640004661 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640004662 Predicted transcriptional regulator [Transcription]; Region: COG2378 1286640004663 HTH domain; Region: HTH_11; pfam08279 1286640004664 WYL domain; Region: WYL; pfam13280 1286640004665 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1286640004666 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1286640004667 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1286640004668 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1286640004669 putative NADH binding site [chemical binding]; other site 1286640004670 putative active site [active] 1286640004671 nudix motif; other site 1286640004672 putative metal binding site [ion binding]; other site 1286640004673 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1286640004674 nucleotide binding site/active site [active] 1286640004675 HIT family signature motif; other site 1286640004676 catalytic residue [active] 1286640004677 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 1286640004678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640004679 Walker A motif; other site 1286640004680 ATP binding site [chemical binding]; other site 1286640004681 Walker B motif; other site 1286640004682 arginine finger; other site 1286640004683 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1286640004684 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 1286640004685 hypothetical protein; Validated; Region: PRK00153 1286640004686 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286640004687 recombination protein RecR; Reviewed; Region: recR; PRK00076 1286640004688 RecR protein; Region: RecR; pfam02132 1286640004689 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1286640004690 putative active site [active] 1286640004691 putative metal-binding site [ion binding]; other site 1286640004692 tetramer interface [polypeptide binding]; other site 1286640004693 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1286640004694 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286640004695 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286640004696 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640004697 Transmembrane secretion effector; Region: MFS_3; pfam05977 1286640004698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640004699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640004700 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1286640004701 Sm and related proteins; Region: Sm_like; cl00259 1286640004702 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1286640004703 putative oligomer interface [polypeptide binding]; other site 1286640004704 putative RNA binding site [nucleotide binding]; other site 1286640004705 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1286640004706 NusA N-terminal domain; Region: NusA_N; pfam08529 1286640004707 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1286640004708 RNA binding site [nucleotide binding]; other site 1286640004709 homodimer interface [polypeptide binding]; other site 1286640004710 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1286640004711 G-X-X-G motif; other site 1286640004712 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1286640004713 G-X-X-G motif; other site 1286640004714 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1286640004715 hypothetical protein; Provisional; Region: PRK09190 1286640004716 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1286640004717 putative RNA binding cleft [nucleotide binding]; other site 1286640004718 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1286640004719 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1286640004720 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1286640004721 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1286640004722 G1 box; other site 1286640004723 putative GEF interaction site [polypeptide binding]; other site 1286640004724 GTP/Mg2+ binding site [chemical binding]; other site 1286640004725 Switch I region; other site 1286640004726 G2 box; other site 1286640004727 G3 box; other site 1286640004728 Switch II region; other site 1286640004729 G4 box; other site 1286640004730 G5 box; other site 1286640004731 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1286640004732 Translation-initiation factor 2; Region: IF-2; pfam11987 1286640004733 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1286640004734 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1286640004735 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 1286640004736 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1286640004737 RNA binding site [nucleotide binding]; other site 1286640004738 active site 1286640004739 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1286640004740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1286640004741 HWE histidine kinase; Region: HWE_HK; pfam07536 1286640004742 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1286640004743 16S/18S rRNA binding site [nucleotide binding]; other site 1286640004744 S13e-L30e interaction site [polypeptide binding]; other site 1286640004745 25S rRNA binding site [nucleotide binding]; other site 1286640004746 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1286640004747 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1286640004748 RNase E interface [polypeptide binding]; other site 1286640004749 trimer interface [polypeptide binding]; other site 1286640004750 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1286640004751 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1286640004752 RNase E interface [polypeptide binding]; other site 1286640004753 trimer interface [polypeptide binding]; other site 1286640004754 active site 1286640004755 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1286640004756 putative nucleic acid binding region [nucleotide binding]; other site 1286640004757 G-X-X-G motif; other site 1286640004758 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1286640004759 RNA binding site [nucleotide binding]; other site 1286640004760 domain interface; other site 1286640004761 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1286640004762 Methyltransferase small domain; Region: MTS; pfam05175 1286640004763 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 1286640004764 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1286640004765 NAD binding site [chemical binding]; other site 1286640004766 homotetramer interface [polypeptide binding]; other site 1286640004767 homodimer interface [polypeptide binding]; other site 1286640004768 substrate binding site [chemical binding]; other site 1286640004769 active site 1286640004770 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1286640004771 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1286640004772 dimer interface [polypeptide binding]; other site 1286640004773 active site 1286640004774 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1286640004775 active site 1 [active] 1286640004776 dimer interface [polypeptide binding]; other site 1286640004777 active site 2 [active] 1286640004778 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1286640004779 metal binding site 2 [ion binding]; metal-binding site 1286640004780 putative DNA binding helix; other site 1286640004781 metal binding site 1 [ion binding]; metal-binding site 1286640004782 dimer interface [polypeptide binding]; other site 1286640004783 Predicted membrane protein [Function unknown]; Region: COG2860 1286640004784 UPF0126 domain; Region: UPF0126; pfam03458 1286640004785 UPF0126 domain; Region: UPF0126; pfam03458 1286640004786 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1286640004787 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1286640004788 putative active site [active] 1286640004789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 1286640004790 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 1286640004791 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1286640004792 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1286640004793 hinge; other site 1286640004794 active site 1286640004795 cytidylate kinase; Provisional; Region: cmk; PRK00023 1286640004796 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1286640004797 CMP-binding site; other site 1286640004798 The sites determining sugar specificity; other site 1286640004799 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1286640004800 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1286640004801 RNA binding site [nucleotide binding]; other site 1286640004802 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1286640004803 RNA binding site [nucleotide binding]; other site 1286640004804 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1286640004805 RNA binding site [nucleotide binding]; other site 1286640004806 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1286640004807 RNA binding site [nucleotide binding]; other site 1286640004808 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1286640004809 RNA binding site [nucleotide binding]; other site 1286640004810 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1286640004811 RNA binding site [nucleotide binding]; other site 1286640004812 BA14K-like protein; Region: BA14K; pfam07886 1286640004813 Cache domain; Region: Cache_1; pfam02743 1286640004814 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1286640004815 dimerization interface [polypeptide binding]; other site 1286640004816 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640004817 cyclase homology domain; Region: CHD; cd07302 1286640004818 nucleotidyl binding site; other site 1286640004819 metal binding site [ion binding]; metal-binding site 1286640004820 dimer interface [polypeptide binding]; other site 1286640004821 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1286640004822 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 1286640004823 putative ligand binding site [chemical binding]; other site 1286640004824 putative NAD binding site [chemical binding]; other site 1286640004825 catalytic site [active] 1286640004826 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1286640004827 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1286640004828 catalytic site [active] 1286640004829 putative active site [active] 1286640004830 putative substrate binding site [chemical binding]; other site 1286640004831 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640004832 Winged helix-turn helix; Region: HTH_29; pfam13551 1286640004833 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640004834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1286640004835 Integrase core domain; Region: rve; pfam00665 1286640004836 Integrase core domain; Region: rve_3; pfam13683 1286640004837 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 1286640004838 GIY-YIG motif/motif A; other site 1286640004839 putative active site [active] 1286640004840 putative metal binding site [ion binding]; other site 1286640004841 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 1286640004842 Predicted membrane protein [Function unknown]; Region: COG2259 1286640004843 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1286640004844 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1286640004845 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 1286640004846 GTP-binding protein LepA; Provisional; Region: PRK05433 1286640004847 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1286640004848 G1 box; other site 1286640004849 putative GEF interaction site [polypeptide binding]; other site 1286640004850 GTP/Mg2+ binding site [chemical binding]; other site 1286640004851 Switch I region; other site 1286640004852 G2 box; other site 1286640004853 G3 box; other site 1286640004854 Switch II region; other site 1286640004855 G4 box; other site 1286640004856 G5 box; other site 1286640004857 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1286640004858 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1286640004859 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1286640004860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640004861 putative substrate translocation pore; other site 1286640004862 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286640004863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640004864 sequence-specific DNA binding site [nucleotide binding]; other site 1286640004865 salt bridge; other site 1286640004866 Cupin domain; Region: Cupin_2; pfam07883 1286640004867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640004868 Coenzyme A binding pocket [chemical binding]; other site 1286640004869 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 1286640004870 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1286640004871 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1286640004872 ligand binding site [chemical binding]; other site 1286640004873 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1286640004874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286640004875 FeS/SAM binding site; other site 1286640004876 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 1286640004877 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1286640004878 motif 1; other site 1286640004879 dimer interface [polypeptide binding]; other site 1286640004880 active site 1286640004881 motif 2; other site 1286640004882 motif 3; other site 1286640004883 elongation factor P; Validated; Region: PRK00529 1286640004884 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1286640004885 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1286640004886 RNA binding site [nucleotide binding]; other site 1286640004887 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1286640004888 RNA binding site [nucleotide binding]; other site 1286640004889 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1286640004890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1286640004891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640004892 S-adenosylmethionine binding site [chemical binding]; other site 1286640004893 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1286640004894 diiron binding motif [ion binding]; other site 1286640004895 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1286640004896 CCC1-related protein family; Region: CCC1_like_1; cd02437 1286640004897 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1286640004898 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286640004899 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1286640004900 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1286640004901 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1286640004902 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1286640004903 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1286640004904 23S rRNA binding site [nucleotide binding]; other site 1286640004905 L21 binding site [polypeptide binding]; other site 1286640004906 L13 binding site [polypeptide binding]; other site 1286640004907 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1286640004908 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1286640004909 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1286640004910 dimer interface [polypeptide binding]; other site 1286640004911 motif 1; other site 1286640004912 active site 1286640004913 motif 2; other site 1286640004914 motif 3; other site 1286640004915 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1286640004916 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1286640004917 putative tRNA-binding site [nucleotide binding]; other site 1286640004918 B3/4 domain; Region: B3_4; pfam03483 1286640004919 tRNA synthetase B5 domain; Region: B5; smart00874 1286640004920 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1286640004921 dimer interface [polypeptide binding]; other site 1286640004922 motif 1; other site 1286640004923 motif 3; other site 1286640004924 motif 2; other site 1286640004925 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1286640004926 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1286640004927 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640004928 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640004929 active site 1286640004930 catalytic tetrad [active] 1286640004931 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1286640004932 catalytic tetrad [active] 1286640004933 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640004934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640004935 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1286640004936 putative effector binding pocket; other site 1286640004937 putative dimerization interface [polypeptide binding]; other site 1286640004938 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1286640004939 dimerization interface [polypeptide binding]; other site 1286640004940 metal binding site [ion binding]; metal-binding site 1286640004941 short chain dehydrogenase; Provisional; Region: PRK07478 1286640004942 classical (c) SDRs; Region: SDR_c; cd05233 1286640004943 NAD(P) binding site [chemical binding]; other site 1286640004944 active site 1286640004945 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640004946 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640004947 active site 1286640004948 catalytic tetrad [active] 1286640004949 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640004950 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640004951 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286640004952 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286640004953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640004954 non-specific DNA binding site [nucleotide binding]; other site 1286640004955 salt bridge; other site 1286640004956 sequence-specific DNA binding site [nucleotide binding]; other site 1286640004957 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1286640004958 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1286640004959 generic binding surface II; other site 1286640004960 generic binding surface I; other site 1286640004961 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1286640004962 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286640004963 MarR family; Region: MarR_2; cl17246 1286640004964 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286640004965 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286640004966 EamA-like transporter family; Region: EamA; pfam00892 1286640004967 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1286640004968 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1286640004969 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640004970 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1286640004971 C-terminal domain interface [polypeptide binding]; other site 1286640004972 GSH binding site (G-site) [chemical binding]; other site 1286640004973 dimer interface [polypeptide binding]; other site 1286640004974 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1286640004975 N-terminal domain interface [polypeptide binding]; other site 1286640004976 dimer interface [polypeptide binding]; other site 1286640004977 substrate binding pocket (H-site) [chemical binding]; other site 1286640004978 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286640004979 MarR family; Region: MarR_2; pfam12802 1286640004980 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1286640004981 putative deacylase active site [active] 1286640004982 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1286640004983 ArsC family; Region: ArsC; pfam03960 1286640004984 putative catalytic residues [active] 1286640004985 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1286640004986 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640004987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640004988 homodimer interface [polypeptide binding]; other site 1286640004989 catalytic residue [active] 1286640004990 Predicted deacylase [General function prediction only]; Region: COG3608 1286640004991 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1286640004992 active site 1286640004993 Zn binding site [ion binding]; other site 1286640004994 VirB8 protein; Region: VirB8; cl01500 1286640004995 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1286640004996 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1286640004997 putative active site [active] 1286640004998 GMP synthase; Reviewed; Region: guaA; PRK00074 1286640004999 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1286640005000 AMP/PPi binding site [chemical binding]; other site 1286640005001 candidate oxyanion hole; other site 1286640005002 catalytic triad [active] 1286640005003 potential glutamine specificity residues [chemical binding]; other site 1286640005004 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1286640005005 ATP Binding subdomain [chemical binding]; other site 1286640005006 Ligand Binding sites [chemical binding]; other site 1286640005007 Dimerization subdomain; other site 1286640005008 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 1286640005009 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 1286640005010 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1286640005011 CoenzymeA binding site [chemical binding]; other site 1286640005012 subunit interaction site [polypeptide binding]; other site 1286640005013 PHB binding site; other site 1286640005014 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1286640005015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640005016 Coenzyme A binding pocket [chemical binding]; other site 1286640005017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 1286640005018 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1286640005019 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 1286640005020 Cl binding site [ion binding]; other site 1286640005021 oligomer interface [polypeptide binding]; other site 1286640005022 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG3489 1286640005023 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1286640005024 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1286640005025 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 1286640005026 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1286640005027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640005028 S-adenosylmethionine binding site [chemical binding]; other site 1286640005029 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1286640005030 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1286640005031 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640005032 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1286640005033 putative NAD(P) binding site [chemical binding]; other site 1286640005034 epoxyqueuosine reductase; Region: TIGR00276 1286640005035 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1286640005036 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640005037 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1286640005038 C-terminal domain interface [polypeptide binding]; other site 1286640005039 GSH binding site (G-site) [chemical binding]; other site 1286640005040 dimer interface [polypeptide binding]; other site 1286640005041 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1286640005042 N-terminal domain interface [polypeptide binding]; other site 1286640005043 dimer interface [polypeptide binding]; other site 1286640005044 substrate binding pocket (H-site) [chemical binding]; other site 1286640005045 Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968 1286640005046 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1286640005047 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1286640005048 putative NAD(P) binding site [chemical binding]; other site 1286640005049 active site 1286640005050 Uncharacterized conserved protein [Function unknown]; Region: COG5470 1286640005051 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1286640005052 active site 1286640005053 dimer interface [polypeptide binding]; other site 1286640005054 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286640005055 catalytic core [active] 1286640005056 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1286640005057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640005058 S-adenosylmethionine binding site [chemical binding]; other site 1286640005059 DNA polymerase III subunit beta; Validated; Region: PRK05643 1286640005060 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1286640005061 putative DNA binding surface [nucleotide binding]; other site 1286640005062 dimer interface [polypeptide binding]; other site 1286640005063 beta-clamp/clamp loader binding surface; other site 1286640005064 beta-clamp/translesion DNA polymerase binding surface; other site 1286640005065 Predicted methyltransferases [General function prediction only]; Region: COG0313 1286640005066 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1286640005067 putative SAM binding site [chemical binding]; other site 1286640005068 putative homodimer interface [polypeptide binding]; other site 1286640005069 hypothetical protein; Reviewed; Region: PRK12497 1286640005070 glutathione synthetase; Provisional; Region: PRK05246 1286640005071 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1286640005072 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1286640005073 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1286640005074 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1286640005075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640005076 Walker A motif; other site 1286640005077 ATP binding site [chemical binding]; other site 1286640005078 Walker B motif; other site 1286640005079 arginine finger; other site 1286640005080 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1286640005081 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1286640005082 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1286640005083 dimer interface [polypeptide binding]; other site 1286640005084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640005085 catalytic residue [active] 1286640005086 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286640005087 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286640005088 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286640005089 EamA-like transporter family; Region: EamA; pfam00892 1286640005090 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640005091 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640005092 putative DNA binding site [nucleotide binding]; other site 1286640005093 putative Zn2+ binding site [ion binding]; other site 1286640005094 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640005095 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1286640005096 trimer interface [polypeptide binding]; other site 1286640005097 active site 1286640005098 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1286640005099 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1286640005100 G1 box; other site 1286640005101 putative GEF interaction site [polypeptide binding]; other site 1286640005102 GTP/Mg2+ binding site [chemical binding]; other site 1286640005103 Switch I region; other site 1286640005104 G2 box; other site 1286640005105 G3 box; other site 1286640005106 Switch II region; other site 1286640005107 G4 box; other site 1286640005108 G5 box; other site 1286640005109 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1286640005110 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286640005111 EamA-like transporter family; Region: EamA; pfam00892 1286640005112 EamA-like transporter family; Region: EamA; pfam00892 1286640005113 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286640005114 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286640005115 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640005116 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640005117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640005118 NAD(P) binding site [chemical binding]; other site 1286640005119 active site 1286640005120 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1286640005121 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1286640005122 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286640005123 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1286640005124 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286640005125 dimer interface [polypeptide binding]; other site 1286640005126 PYR/PP interface [polypeptide binding]; other site 1286640005127 TPP binding site [chemical binding]; other site 1286640005128 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286640005129 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1286640005130 TPP-binding site [chemical binding]; other site 1286640005131 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286640005132 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1286640005133 substrate binding site [chemical binding]; other site 1286640005134 ATP binding site [chemical binding]; other site 1286640005135 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1286640005136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1286640005137 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286640005138 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286640005139 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286640005140 putative active site [active] 1286640005141 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640005142 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640005143 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286640005144 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1286640005145 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1286640005146 putative active site [active] 1286640005147 putative dimer interface [polypeptide binding]; other site 1286640005148 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1286640005149 Flavoprotein; Region: Flavoprotein; pfam02441 1286640005150 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1286640005151 Predicted transcriptional regulator [Transcription]; Region: COG1959 1286640005152 Transcriptional regulator; Region: Rrf2; pfam02082 1286640005153 Transcriptional regulator; Region: Rrf2; cl17282 1286640005154 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1286640005155 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1286640005156 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1286640005157 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1286640005158 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1286640005159 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640005160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640005161 NAD(P) binding site [chemical binding]; other site 1286640005162 active site 1286640005163 ABC1 family; Region: ABC1; cl17513 1286640005164 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1286640005165 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1286640005166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640005167 S-adenosylmethionine binding site [chemical binding]; other site 1286640005168 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1286640005169 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1286640005170 DNA binding site [nucleotide binding] 1286640005171 catalytic residue [active] 1286640005172 H2TH interface [polypeptide binding]; other site 1286640005173 putative catalytic residues [active] 1286640005174 turnover-facilitating residue; other site 1286640005175 intercalation triad [nucleotide binding]; other site 1286640005176 8OG recognition residue [nucleotide binding]; other site 1286640005177 putative reading head residues; other site 1286640005178 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1286640005179 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1286640005180 enoyl-CoA hydratase; Provisional; Region: PRK05862 1286640005181 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286640005182 substrate binding site [chemical binding]; other site 1286640005183 oxyanion hole (OAH) forming residues; other site 1286640005184 trimer interface [polypeptide binding]; other site 1286640005185 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1286640005186 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1286640005187 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1286640005188 Bacterial dnaA protein; Region: Bac_DnaA; pfam00308 1286640005189 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1286640005190 DnaA box-binding interface [nucleotide binding]; other site 1286640005191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1286640005192 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1286640005193 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286640005194 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1286640005195 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 1286640005196 putative hydrophobic ligand binding site [chemical binding]; other site 1286640005197 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1286640005198 SnoaL-like domain; Region: SnoaL_3; pfam13474 1286640005199 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1286640005200 putative dimer interface [polypeptide binding]; other site 1286640005201 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640005202 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 1286640005203 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286640005204 FeS/SAM binding site; other site 1286640005205 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1286640005206 active site 1286640005207 dimerization interface [polypeptide binding]; other site 1286640005208 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286640005209 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640005210 active site 1286640005211 ribonuclease PH; Reviewed; Region: rph; PRK00173 1286640005212 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1286640005213 hexamer interface [polypeptide binding]; other site 1286640005214 active site 1286640005215 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1286640005216 heat shock protein GrpE; Provisional; Region: PRK14141 1286640005217 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1286640005218 dimer interface [polypeptide binding]; other site 1286640005219 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1286640005220 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286640005221 active site 1286640005222 phosphorylation site [posttranslational modification] 1286640005223 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1286640005224 30S subunit binding site; other site 1286640005225 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1286640005226 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1286640005227 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1286640005228 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1286640005229 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1286640005230 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1286640005231 Walker A/P-loop; other site 1286640005232 ATP binding site [chemical binding]; other site 1286640005233 Q-loop/lid; other site 1286640005234 ABC transporter signature motif; other site 1286640005235 Walker B; other site 1286640005236 D-loop; other site 1286640005237 H-loop/switch region; other site 1286640005238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 1286640005239 OstA-like protein; Region: OstA; pfam03968 1286640005240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 1286640005241 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1286640005242 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1286640005243 tandem repeat interface [polypeptide binding]; other site 1286640005244 oligomer interface [polypeptide binding]; other site 1286640005245 active site residues [active] 1286640005246 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1286640005247 IHF dimer interface [polypeptide binding]; other site 1286640005248 IHF - DNA interface [nucleotide binding]; other site 1286640005249 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 1286640005250 putative hydrophobic ligand binding site [chemical binding]; other site 1286640005251 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1286640005252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640005253 S-adenosylmethionine binding site [chemical binding]; other site 1286640005254 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1286640005255 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1286640005256 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1286640005257 lipoprotein signal peptidase; Provisional; Region: PRK14795 1286640005258 PAS fold; Region: PAS_4; pfam08448 1286640005259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640005260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640005261 dimer interface [polypeptide binding]; other site 1286640005262 phosphorylation site [posttranslational modification] 1286640005263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640005264 ATP binding site [chemical binding]; other site 1286640005265 Mg2+ binding site [ion binding]; other site 1286640005266 G-X-G motif; other site 1286640005267 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640005268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640005269 active site 1286640005270 phosphorylation site [posttranslational modification] 1286640005271 intermolecular recognition site; other site 1286640005272 dimerization interface [polypeptide binding]; other site 1286640005273 Putative hemolysin [General function prediction only]; Region: COG3176 1286640005274 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1286640005275 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1286640005276 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1286640005277 putative NAD(P) binding site [chemical binding]; other site 1286640005278 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1286640005279 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1286640005280 MutS domain I; Region: MutS_I; pfam01624 1286640005281 MutS domain II; Region: MutS_II; pfam05188 1286640005282 MutS domain III; Region: MutS_III; pfam05192 1286640005283 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1286640005284 Walker A/P-loop; other site 1286640005285 ATP binding site [chemical binding]; other site 1286640005286 Q-loop/lid; other site 1286640005287 ABC transporter signature motif; other site 1286640005288 Walker B; other site 1286640005289 D-loop; other site 1286640005290 H-loop/switch region; other site 1286640005291 PII uridylyl-transferase; Provisional; Region: PRK05092 1286640005292 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1286640005293 metal binding triad; other site 1286640005294 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1286640005295 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286640005296 Zn2+ binding site [ion binding]; other site 1286640005297 Mg2+ binding site [ion binding]; other site 1286640005298 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1286640005299 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1286640005300 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1286640005301 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1286640005302 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640005303 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1286640005304 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1286640005305 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1286640005306 active site 1286640005307 HIGH motif; other site 1286640005308 dimer interface [polypeptide binding]; other site 1286640005309 KMSKS motif; other site 1286640005310 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286640005311 Ligand Binding Site [chemical binding]; other site 1286640005312 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 1286640005313 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1286640005314 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1286640005315 Glycoprotease family; Region: Peptidase_M22; pfam00814 1286640005316 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286640005317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640005318 Coenzyme A binding pocket [chemical binding]; other site 1286640005319 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1286640005320 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1286640005321 putative acyl-acceptor binding pocket; other site 1286640005322 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1286640005323 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1286640005324 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286640005325 FeS/SAM binding site; other site 1286640005326 TRAM domain; Region: TRAM; pfam01938 1286640005327 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1286640005328 PhoH-like protein; Region: PhoH; pfam02562 1286640005329 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 1286640005330 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1286640005331 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1286640005332 Transporter associated domain; Region: CorC_HlyC; smart01091 1286640005333 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1286640005334 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1286640005335 putative active site [active] 1286640005336 catalytic triad [active] 1286640005337 putative dimer interface [polypeptide binding]; other site 1286640005338 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286640005339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640005340 non-specific DNA binding site [nucleotide binding]; other site 1286640005341 salt bridge; other site 1286640005342 sequence-specific DNA binding site [nucleotide binding]; other site 1286640005343 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1286640005344 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1286640005345 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1286640005346 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1286640005347 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 1286640005348 Uncharacterized small protein [Function unknown]; Region: COG5568 1286640005349 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1286640005350 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1286640005351 putative dimer interface [polypeptide binding]; other site 1286640005352 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1286640005353 active site 1286640005354 tetramer interface [polypeptide binding]; other site 1286640005355 Cache domain; Region: Cache_1; pfam02743 1286640005356 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1286640005357 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1286640005358 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286640005359 dimer interface [polypeptide binding]; other site 1286640005360 putative CheW interface [polypeptide binding]; other site 1286640005361 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286640005362 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1286640005363 substrate binding site [chemical binding]; other site 1286640005364 dimer interface [polypeptide binding]; other site 1286640005365 ATP binding site [chemical binding]; other site 1286640005366 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1286640005367 RmuC family; Region: RmuC; pfam02646 1286640005368 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1286640005369 active site 1286640005370 catalytic residues [active] 1286640005371 metal binding site [ion binding]; metal-binding site 1286640005372 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1286640005373 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1286640005374 putative active site [active] 1286640005375 substrate binding site [chemical binding]; other site 1286640005376 putative cosubstrate binding site; other site 1286640005377 catalytic site [active] 1286640005378 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1286640005379 substrate binding site [chemical binding]; other site 1286640005380 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1286640005381 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1286640005382 dimerization interface 3.5A [polypeptide binding]; other site 1286640005383 active site 1286640005384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286640005385 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286640005386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286640005387 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286640005388 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1286640005389 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1286640005390 metal binding site [ion binding]; metal-binding site 1286640005391 dimer interface [polypeptide binding]; other site 1286640005392 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1286640005393 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286640005394 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640005395 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640005396 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1286640005397 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640005398 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640005399 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1286640005400 putative effector binding pocket; other site 1286640005401 putative dimerization interface [polypeptide binding]; other site 1286640005402 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286640005403 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286640005404 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1286640005405 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1286640005406 ATP binding site [chemical binding]; other site 1286640005407 putative Mg++ binding site [ion binding]; other site 1286640005408 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286640005409 nucleotide binding region [chemical binding]; other site 1286640005410 ATP-binding site [chemical binding]; other site 1286640005411 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1286640005412 RNA binding site [nucleotide binding]; other site 1286640005413 Predicted membrane protein [Function unknown]; Region: COG3152 1286640005414 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1286640005415 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1286640005416 trimer interface [polypeptide binding]; other site 1286640005417 active site 1286640005418 substrate binding site [chemical binding]; other site 1286640005419 CoA binding site [chemical binding]; other site 1286640005420 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1286640005421 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 1286640005422 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1286640005423 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1286640005424 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1286640005425 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1286640005426 DNA binding site [nucleotide binding] 1286640005427 active site 1286640005428 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1286640005429 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1286640005430 tetramer interface [polypeptide binding]; other site 1286640005431 active site 1286640005432 Mg2+/Mn2+ binding site [ion binding]; other site 1286640005433 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1286640005434 homohexameric interface [polypeptide binding]; other site 1286640005435 feedback inhibition sensing region; other site 1286640005436 carbamate kinase; Reviewed; Region: PRK12686 1286640005437 nucleotide binding site [chemical binding]; other site 1286640005438 N-acetyl-L-glutamate binding site [chemical binding]; other site 1286640005439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 1286640005440 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1286640005441 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1286640005442 SelR domain; Region: SelR; pfam01641 1286640005443 Predicted membrane protein [Function unknown]; Region: COG4803 1286640005444 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1286640005445 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 1286640005446 G1 box; other site 1286640005447 GTP/Mg2+ binding site [chemical binding]; other site 1286640005448 Switch I region; other site 1286640005449 G2 box; other site 1286640005450 G3 box; other site 1286640005451 Switch II region; other site 1286640005452 G4 box; other site 1286640005453 G5 box; other site 1286640005454 membrane protein insertase; Provisional; Region: PRK01318 1286640005455 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1286640005456 ribonuclease P; Reviewed; Region: rnpA; PRK01313 1286640005457 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1286640005458 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286640005459 dimerization interface [polypeptide binding]; other site 1286640005460 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286640005461 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286640005462 dimer interface [polypeptide binding]; other site 1286640005463 putative CheW interface [polypeptide binding]; other site 1286640005464 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1286640005465 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1286640005466 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1286640005467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286640005468 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640005469 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286640005470 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640005471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640005472 ATP binding site [chemical binding]; other site 1286640005473 Mg2+ binding site [ion binding]; other site 1286640005474 G-X-G motif; other site 1286640005475 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1286640005476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640005477 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1286640005478 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286640005479 homotrimer interaction site [polypeptide binding]; other site 1286640005480 putative active site [active] 1286640005481 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1286640005482 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1286640005483 phosphate binding site [ion binding]; other site 1286640005484 Domain of unknown function DUF11; Region: DUF11; cl17728 1286640005485 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1286640005486 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1286640005487 Domain of unknown function DUF11; Region: DUF11; cl17728 1286640005488 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1286640005489 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1286640005490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 1286640005491 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1286640005492 trimer interface [polypeptide binding]; other site 1286640005493 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1286640005494 trimer interface [polypeptide binding]; other site 1286640005495 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1286640005496 trimer interface [polypeptide binding]; other site 1286640005497 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1286640005498 trimer interface [polypeptide binding]; other site 1286640005499 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1286640005500 trimer interface [polypeptide binding]; other site 1286640005501 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1286640005502 Haemagglutinin; Region: HIM; pfam05662 1286640005503 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 1286640005504 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1286640005505 putative deacylase active site [active] 1286640005506 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1286640005507 Uncharacterized conserved protein [Function unknown]; Region: COG5579 1286640005508 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640005509 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640005510 active site 1286640005511 catalytic tetrad [active] 1286640005512 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1286640005513 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1286640005514 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1286640005515 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 1286640005516 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1286640005517 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1286640005518 Glutamate binding site [chemical binding]; other site 1286640005519 NAD binding site [chemical binding]; other site 1286640005520 catalytic residues [active] 1286640005521 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1286640005522 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1286640005523 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1286640005524 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286640005525 active site 1286640005526 metal binding site [ion binding]; metal-binding site 1286640005527 hexamer interface [polypeptide binding]; other site 1286640005528 FecR protein; Region: FecR; pfam04773 1286640005529 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1286640005530 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 1286640005531 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640005532 cyclase homology domain; Region: CHD; cd07302 1286640005533 nucleotidyl binding site; other site 1286640005534 metal binding site [ion binding]; metal-binding site 1286640005535 dimer interface [polypeptide binding]; other site 1286640005536 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286640005537 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286640005538 ligand binding site [chemical binding]; other site 1286640005539 flexible hinge region; other site 1286640005540 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1286640005541 putative switch regulator; other site 1286640005542 non-specific DNA interactions [nucleotide binding]; other site 1286640005543 DNA binding site [nucleotide binding] 1286640005544 sequence specific DNA binding site [nucleotide binding]; other site 1286640005545 putative cAMP binding site [chemical binding]; other site 1286640005546 Predicted membrane protein [Function unknown]; Region: COG2259 1286640005547 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 1286640005548 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1286640005549 non-specific DNA interactions [nucleotide binding]; other site 1286640005550 DNA binding site [nucleotide binding] 1286640005551 sequence specific DNA binding site [nucleotide binding]; other site 1286640005552 putative cAMP binding site [chemical binding]; other site 1286640005553 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286640005554 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286640005555 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640005556 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1286640005557 ligand binding site [chemical binding]; other site 1286640005558 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640005559 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640005560 TM-ABC transporter signature motif; other site 1286640005561 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1286640005562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640005563 Walker A/P-loop; other site 1286640005564 ATP binding site [chemical binding]; other site 1286640005565 Q-loop/lid; other site 1286640005566 ABC transporter signature motif; other site 1286640005567 Walker B; other site 1286640005568 D-loop; other site 1286640005569 H-loop/switch region; other site 1286640005570 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1286640005571 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1286640005572 active site 1286640005573 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1286640005574 active site 1286640005575 substrate binding pocket [chemical binding]; other site 1286640005576 dimer interface [polypeptide binding]; other site 1286640005577 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286640005578 active site 1286640005579 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286640005580 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1286640005581 putative substrate binding site [chemical binding]; other site 1286640005582 putative ATP binding site [chemical binding]; other site 1286640005583 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1286640005584 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1286640005585 active site 1286640005586 dimer interface [polypeptide binding]; other site 1286640005587 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1286640005588 dimer interface [polypeptide binding]; other site 1286640005589 active site 1286640005590 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 1286640005591 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1286640005592 acyl-activating enzyme (AAE) consensus motif; other site 1286640005593 putative AMP binding site [chemical binding]; other site 1286640005594 putative active site [active] 1286640005595 putative CoA binding site [chemical binding]; other site 1286640005596 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286640005597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640005598 putative substrate translocation pore; other site 1286640005599 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1286640005600 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1286640005601 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1286640005602 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1286640005603 putative acyl-acceptor binding pocket; other site 1286640005604 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1286640005605 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1286640005606 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 1286640005607 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1286640005608 integrase; Provisional; Region: PRK09692 1286640005609 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1286640005610 active site 1286640005611 Int/Topo IB signature motif; other site 1286640005612 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1286640005613 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286640005614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640005615 non-specific DNA binding site [nucleotide binding]; other site 1286640005616 salt bridge; other site 1286640005617 sequence-specific DNA binding site [nucleotide binding]; other site 1286640005618 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 1286640005619 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 1286640005620 Protein of unknown function (DUF499); Region: DUF499; pfam04465 1286640005621 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1286640005622 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1286640005623 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1286640005624 TIGR02646 family protein; Region: TIGR02646 1286640005625 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 1286640005626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640005627 Walker A/P-loop; other site 1286640005628 ATP binding site [chemical binding]; other site 1286640005629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640005630 Q-loop/lid; other site 1286640005631 ABC transporter signature motif; other site 1286640005632 Walker B; other site 1286640005633 D-loop; other site 1286640005634 H-loop/switch region; other site 1286640005635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286640005636 ATP binding site [chemical binding]; other site 1286640005637 putative Mg++ binding site [ion binding]; other site 1286640005638 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1286640005639 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286640005640 nucleotide binding region [chemical binding]; other site 1286640005641 ATP-binding site [chemical binding]; other site 1286640005642 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1286640005643 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1286640005644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640005645 sequence-specific DNA binding site [nucleotide binding]; other site 1286640005646 salt bridge; other site 1286640005647 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1286640005648 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1286640005649 FMN binding site [chemical binding]; other site 1286640005650 substrate binding site [chemical binding]; other site 1286640005651 putative catalytic residue [active] 1286640005652 Uncharacterized conserved protein [Function unknown]; Region: COG2326 1286640005653 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1286640005654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640005655 dimer interface [polypeptide binding]; other site 1286640005656 phosphorylation site [posttranslational modification] 1286640005657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640005658 ATP binding site [chemical binding]; other site 1286640005659 Mg2+ binding site [ion binding]; other site 1286640005660 G-X-G motif; other site 1286640005661 PBP superfamily domain; Region: PBP_like_2; pfam12849 1286640005662 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 1286640005663 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1286640005664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640005665 dimer interface [polypeptide binding]; other site 1286640005666 conserved gate region; other site 1286640005667 putative PBP binding loops; other site 1286640005668 ABC-ATPase subunit interface; other site 1286640005669 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1286640005670 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1286640005671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640005672 dimer interface [polypeptide binding]; other site 1286640005673 conserved gate region; other site 1286640005674 putative PBP binding loops; other site 1286640005675 ABC-ATPase subunit interface; other site 1286640005676 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 1286640005677 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1286640005678 Walker A/P-loop; other site 1286640005679 ATP binding site [chemical binding]; other site 1286640005680 Q-loop/lid; other site 1286640005681 ABC transporter signature motif; other site 1286640005682 Walker B; other site 1286640005683 D-loop; other site 1286640005684 H-loop/switch region; other site 1286640005685 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1286640005686 PhoU domain; Region: PhoU; pfam01895 1286640005687 PhoU domain; Region: PhoU; pfam01895 1286640005688 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1286640005689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640005690 active site 1286640005691 phosphorylation site [posttranslational modification] 1286640005692 intermolecular recognition site; other site 1286640005693 dimerization interface [polypeptide binding]; other site 1286640005694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640005695 DNA binding site [nucleotide binding] 1286640005696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 1286640005697 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 1286640005698 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640005699 inhibitor-cofactor binding pocket; inhibition site 1286640005700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640005701 catalytic residue [active] 1286640005702 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1286640005703 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1286640005704 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1286640005705 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1286640005706 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1286640005707 dimerization interface [polypeptide binding]; other site 1286640005708 domain crossover interface; other site 1286640005709 redox-dependent activation switch; other site 1286640005710 Uncharacterized protein affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism]; Region: ApaG; COG2967 1286640005711 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1286640005712 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 1286640005713 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286640005714 homodimer interface [polypeptide binding]; other site 1286640005715 substrate-cofactor binding pocket; other site 1286640005716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640005717 catalytic residue [active] 1286640005718 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 1286640005719 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 1286640005720 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1286640005721 trimer interface [polypeptide binding]; other site 1286640005722 active site 1286640005723 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 1286640005724 trimer interface [polypeptide binding]; other site 1286640005725 active site 1286640005726 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286640005727 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640005728 substrate binding pocket [chemical binding]; other site 1286640005729 membrane-bound complex binding site; other site 1286640005730 hinge residues; other site 1286640005731 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1286640005732 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1286640005733 tellurite resistance protein terB; Region: terB; cd07176 1286640005734 putative metal binding site [ion binding]; other site 1286640005735 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1286640005736 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1286640005737 Predicted transcriptional regulator [Transcription]; Region: COG2932 1286640005738 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1286640005739 Catalytic site [active] 1286640005740 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1286640005741 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1286640005742 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286640005743 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286640005744 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 1286640005745 putative hydrophobic ligand binding site [chemical binding]; other site 1286640005746 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1286640005747 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286640005748 substrate binding site [chemical binding]; other site 1286640005749 oxyanion hole (OAH) forming residues; other site 1286640005750 trimer interface [polypeptide binding]; other site 1286640005751 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1286640005752 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286640005753 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286640005754 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1286640005755 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286640005756 dimer interface [polypeptide binding]; other site 1286640005757 active site 1286640005758 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1286640005759 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1286640005760 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1286640005761 FAD binding site [chemical binding]; other site 1286640005762 substrate binding site [chemical binding]; other site 1286640005763 catalytic residues [active] 1286640005764 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1286640005765 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1286640005766 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1286640005767 Sel1-like repeats; Region: SEL1; smart00671 1286640005768 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1286640005769 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640005770 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286640005771 conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186 1286640005772 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640005773 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640005774 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286640005775 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 1286640005776 putative active site [active] 1286640005777 putative metal binding site [ion binding]; other site 1286640005778 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 1286640005779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286640005780 ATP binding site [chemical binding]; other site 1286640005781 putative Mg++ binding site [ion binding]; other site 1286640005782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286640005783 nucleotide binding region [chemical binding]; other site 1286640005784 ATP-binding site [chemical binding]; other site 1286640005785 DEAD/H associated; Region: DEAD_assoc; pfam08494 1286640005786 Predicted transcriptional regulator [Transcription]; Region: COG1959 1286640005787 Transcriptional regulator; Region: Rrf2; pfam02082 1286640005788 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1286640005789 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1286640005790 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1286640005791 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286640005792 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286640005793 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 1286640005794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640005795 S-adenosylmethionine binding site [chemical binding]; other site 1286640005796 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1286640005797 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1286640005798 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1286640005799 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1286640005800 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1286640005801 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1286640005802 quinone interaction residues [chemical binding]; other site 1286640005803 active site 1286640005804 catalytic residues [active] 1286640005805 FMN binding site [chemical binding]; other site 1286640005806 substrate binding site [chemical binding]; other site 1286640005807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 1286640005808 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640005809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640005810 active site 1286640005811 phosphorylation site [posttranslational modification] 1286640005812 intermolecular recognition site; other site 1286640005813 dimerization interface [polypeptide binding]; other site 1286640005814 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640005815 DNA binding residues [nucleotide binding] 1286640005816 dimerization interface [polypeptide binding]; other site 1286640005817 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1286640005818 Na binding site [ion binding]; other site 1286640005819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640005820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640005821 dimer interface [polypeptide binding]; other site 1286640005822 phosphorylation site [posttranslational modification] 1286640005823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640005824 ATP binding site [chemical binding]; other site 1286640005825 Mg2+ binding site [ion binding]; other site 1286640005826 G-X-G motif; other site 1286640005827 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1286640005828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640005829 active site 1286640005830 phosphorylation site [posttranslational modification] 1286640005831 intermolecular recognition site; other site 1286640005832 dimerization interface [polypeptide binding]; other site 1286640005833 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1286640005834 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1286640005835 aspartate aminotransferase; Provisional; Region: PRK06108 1286640005836 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640005837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640005838 homodimer interface [polypeptide binding]; other site 1286640005839 catalytic residue [active] 1286640005840 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1286640005841 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1286640005842 NAD binding site [chemical binding]; other site 1286640005843 homodimer interface [polypeptide binding]; other site 1286640005844 active site 1286640005845 substrate binding site [chemical binding]; other site 1286640005846 chorismate mutase related enzymes; Region: CM-like; TIGR01803 1286640005847 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1286640005848 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1286640005849 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1286640005850 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1286640005851 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1286640005852 metal binding site [ion binding]; metal-binding site 1286640005853 putative dimer interface [polypeptide binding]; other site 1286640005854 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640005855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640005856 dimer interface [polypeptide binding]; other site 1286640005857 conserved gate region; other site 1286640005858 putative PBP binding loops; other site 1286640005859 ABC-ATPase subunit interface; other site 1286640005860 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640005861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640005862 dimer interface [polypeptide binding]; other site 1286640005863 conserved gate region; other site 1286640005864 putative PBP binding loops; other site 1286640005865 ABC-ATPase subunit interface; other site 1286640005866 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640005867 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286640005868 substrate binding pocket [chemical binding]; other site 1286640005869 membrane-bound complex binding site; other site 1286640005870 hinge residues; other site 1286640005871 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1286640005872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640005873 Walker A/P-loop; other site 1286640005874 ATP binding site [chemical binding]; other site 1286640005875 Q-loop/lid; other site 1286640005876 ABC transporter signature motif; other site 1286640005877 Walker B; other site 1286640005878 D-loop; other site 1286640005879 H-loop/switch region; other site 1286640005880 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1286640005881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640005882 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1286640005883 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1286640005884 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640005885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640005886 homodimer interface [polypeptide binding]; other site 1286640005887 catalytic residue [active] 1286640005888 hypothetical protein; Provisional; Region: PRK07524 1286640005889 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286640005890 PYR/PP interface [polypeptide binding]; other site 1286640005891 dimer interface [polypeptide binding]; other site 1286640005892 TPP binding site [chemical binding]; other site 1286640005893 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286640005894 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1286640005895 TPP-binding site [chemical binding]; other site 1286640005896 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1286640005897 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1286640005898 Protein export membrane protein; Region: SecD_SecF; pfam02355 1286640005899 Rrf2 family protein; Region: rrf2_super; TIGR00738 1286640005900 Transcriptional regulator; Region: Rrf2; pfam02082 1286640005901 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1286640005902 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1286640005903 putative active site [active] 1286640005904 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1286640005905 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 1286640005906 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1286640005907 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1286640005908 Sulfatase; Region: Sulfatase; cl17466 1286640005909 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1286640005910 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 1286640005911 putative NAD(P) binding site [chemical binding]; other site 1286640005912 homotetramer interface [polypeptide binding]; other site 1286640005913 active site 1286640005914 homodimer interface [polypeptide binding]; other site 1286640005915 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1286640005916 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1286640005917 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286640005918 catalytic residue [active] 1286640005919 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1286640005920 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1286640005921 active site 1286640005922 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1286640005923 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1286640005924 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1286640005925 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1286640005926 Enoylreductase; Region: PKS_ER; smart00829 1286640005927 NAD(P) binding site [chemical binding]; other site 1286640005928 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1286640005929 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1286640005930 putative NADP binding site [chemical binding]; other site 1286640005931 active site 1286640005932 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1286640005933 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1286640005934 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1286640005935 SLBB domain; Region: SLBB; pfam10531 1286640005936 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1286640005937 Isochorismatase family; Region: Isochorismatase; pfam00857 1286640005938 catalytic triad [active] 1286640005939 metal binding site [ion binding]; metal-binding site 1286640005940 conserved cis-peptide bond; other site 1286640005941 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 1286640005942 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 1286640005943 active site 1286640005944 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1286640005945 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1286640005946 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1286640005947 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1286640005948 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1286640005949 Uncharacterized conserved protein [Function unknown]; Region: COG5569 1286640005950 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640005951 cyclase homology domain; Region: CHD; cd07302 1286640005952 nucleotidyl binding site; other site 1286640005953 metal binding site [ion binding]; metal-binding site 1286640005954 dimer interface [polypeptide binding]; other site 1286640005955 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1286640005956 RNA/DNA hybrid binding site [nucleotide binding]; other site 1286640005957 active site 1286640005958 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1286640005959 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1286640005960 catalytic residues [active] 1286640005961 catalytic nucleophile [active] 1286640005962 Presynaptic Site I dimer interface [polypeptide binding]; other site 1286640005963 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1286640005964 Synaptic Flat tetramer interface [polypeptide binding]; other site 1286640005965 Synaptic Site I dimer interface [polypeptide binding]; other site 1286640005966 DNA binding site [nucleotide binding] 1286640005967 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1286640005968 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1286640005969 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1286640005970 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640005971 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640005972 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1286640005973 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1286640005974 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286640005975 ATP binding site [chemical binding]; other site 1286640005976 putative Mg++ binding site [ion binding]; other site 1286640005977 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1286640005978 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1286640005979 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1286640005980 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1286640005981 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1286640005982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640005983 S-adenosylmethionine binding site [chemical binding]; other site 1286640005984 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 1286640005985 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1286640005986 Int/Topo IB signature motif; other site 1286640005987 Transposase; Region: HTH_Tnp_1; cl17663 1286640005988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286640005989 HTH-like domain; Region: HTH_21; pfam13276 1286640005990 Integrase core domain; Region: rve; pfam00665 1286640005991 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1286640005992 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1286640005993 catalytic residues [active] 1286640005994 catalytic nucleophile [active] 1286640005995 Recombinase; Region: Recombinase; pfam07508 1286640005996 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1286640005997 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640005998 Winged helix-turn helix; Region: HTH_29; pfam13551 1286640005999 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1286640006000 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1286640006001 hinge; other site 1286640006002 active site 1286640006003 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 1286640006004 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1286640006005 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1286640006006 NAD binding site [chemical binding]; other site 1286640006007 dimerization interface [polypeptide binding]; other site 1286640006008 product binding site; other site 1286640006009 substrate binding site [chemical binding]; other site 1286640006010 zinc binding site [ion binding]; other site 1286640006011 catalytic residues [active] 1286640006012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5328 1286640006013 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1286640006014 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1286640006015 active site 1286640006016 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1286640006017 rRNA binding site [nucleotide binding]; other site 1286640006018 predicted 30S ribosome binding site; other site 1286640006019 Maf-like protein; Region: Maf; pfam02545 1286640006020 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1286640006021 active site 1286640006022 dimer interface [polypeptide binding]; other site 1286640006023 zinc-binding protein; Provisional; Region: PRK01343 1286640006024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 1286640006025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 1286640006026 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1286640006027 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1286640006028 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1286640006029 active site 1286640006030 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 1286640006031 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1286640006032 putative deacylase active site [active] 1286640006033 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952 1286640006034 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 1286640006035 short chain dehydrogenase; Validated; Region: PRK08324 1286640006036 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1286640006037 active site 1286640006038 Zn2+ binding site [ion binding]; other site 1286640006039 intersubunit interface [polypeptide binding]; other site 1286640006040 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1286640006041 putative NAD(P) binding site [chemical binding]; other site 1286640006042 active site 1286640006043 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1286640006044 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1286640006045 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286640006046 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1286640006047 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 1286640006048 ligand binding site [chemical binding]; other site 1286640006049 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640006050 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640006051 Walker A/P-loop; other site 1286640006052 ATP binding site [chemical binding]; other site 1286640006053 Q-loop/lid; other site 1286640006054 ABC transporter signature motif; other site 1286640006055 Walker B; other site 1286640006056 D-loop; other site 1286640006057 H-loop/switch region; other site 1286640006058 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640006059 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640006060 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640006061 TM-ABC transporter signature motif; other site 1286640006062 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640006063 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640006064 TM-ABC transporter signature motif; other site 1286640006065 Uncharacterized conserved protein [Function unknown]; Region: COG3254 1286640006066 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1286640006067 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 1286640006068 N- and C-terminal domain interface [polypeptide binding]; other site 1286640006069 putative active site [active] 1286640006070 putative MgATP binding site [chemical binding]; other site 1286640006071 putative catalytic site [active] 1286640006072 metal binding site [ion binding]; metal-binding site 1286640006073 putative carbohydrate binding site [chemical binding]; other site 1286640006074 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1286640006075 heme-binding site [chemical binding]; other site 1286640006076 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286640006077 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286640006078 dimer interface [polypeptide binding]; other site 1286640006079 putative CheW interface [polypeptide binding]; other site 1286640006080 STAS domain; Region: STAS_2; pfam13466 1286640006081 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640006082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640006083 active site 1286640006084 phosphorylation site [posttranslational modification] 1286640006085 intermolecular recognition site; other site 1286640006086 dimerization interface [polypeptide binding]; other site 1286640006087 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1286640006088 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1286640006089 putative binding surface; other site 1286640006090 active site 1286640006091 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1286640006092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640006093 ATP binding site [chemical binding]; other site 1286640006094 Mg2+ binding site [ion binding]; other site 1286640006095 G-X-G motif; other site 1286640006096 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1286640006097 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1286640006098 putative CheA interaction surface; other site 1286640006099 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1286640006100 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1286640006101 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1286640006102 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1286640006103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640006104 active site 1286640006105 phosphorylation site [posttranslational modification] 1286640006106 intermolecular recognition site; other site 1286640006107 dimerization interface [polypeptide binding]; other site 1286640006108 CheB methylesterase; Region: CheB_methylest; pfam01339 1286640006109 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640006110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640006111 active site 1286640006112 phosphorylation site [posttranslational modification] 1286640006113 intermolecular recognition site; other site 1286640006114 dimerization interface [polypeptide binding]; other site 1286640006115 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13497 1286640006116 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1286640006117 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1286640006118 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1286640006119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640006120 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640006121 dimerization interface [polypeptide binding]; other site 1286640006122 DNA binding residues [nucleotide binding] 1286640006123 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640006124 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640006125 DNA binding residues [nucleotide binding] 1286640006126 dimerization interface [polypeptide binding]; other site 1286640006127 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 1286640006128 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1286640006129 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1286640006130 FliG C-terminal domain; Region: FliG_C; pfam01706 1286640006131 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1286640006132 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 1286640006133 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1286640006134 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1286640006135 flagellar motor protein MotA; Validated; Region: PRK09110 1286640006136 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1286640006137 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1286640006138 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 1286640006139 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1286640006140 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1286640006141 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 1286640006142 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286640006143 Walker A motif; other site 1286640006144 ATP binding site [chemical binding]; other site 1286640006145 Walker B motif; other site 1286640006146 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 1286640006147 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 1286640006148 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1286640006149 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1286640006150 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 1286640006151 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 1286640006152 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1286640006153 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 1286640006154 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1286640006155 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1286640006156 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1286640006157 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1286640006158 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1286640006159 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1286640006160 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1286640006161 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1286640006162 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1286640006163 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 1286640006164 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1286640006165 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1286640006166 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 1286640006167 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1286640006168 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1286640006169 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 1286640006170 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1286640006171 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1286640006172 flagellin; Reviewed; Region: PRK12687 1286640006173 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1286640006174 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1286640006175 flagellar motor protein MotB; Validated; Region: motB; PRK05996 1286640006176 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1286640006177 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1286640006178 ligand binding site [chemical binding]; other site 1286640006179 chemotaxis protein; Reviewed; Region: PRK12798 1286640006180 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1286640006181 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1286640006182 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286640006183 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286640006184 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640006185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640006186 DNA binding site [nucleotide binding] 1286640006187 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1286640006188 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1286640006189 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1286640006190 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1286640006191 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 1286640006192 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 1286640006193 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1286640006194 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1286640006195 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 1286640006196 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 1286640006197 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 1286640006198 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 1286640006199 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1286640006200 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 1286640006201 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1286640006202 FHIPEP family; Region: FHIPEP; pfam00771 1286640006203 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1286640006204 Rod binding protein; Region: Rod-binding; pfam10135 1286640006205 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1286640006206 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286640006207 active site 1286640006208 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 1286640006209 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1286640006210 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1286640006211 homodimer interface [polypeptide binding]; other site 1286640006212 NADP binding site [chemical binding]; other site 1286640006213 substrate binding site [chemical binding]; other site 1286640006214 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640006215 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640006216 DNA binding site [nucleotide binding] 1286640006217 domain linker motif; other site 1286640006218 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1286640006219 ligand binding site [chemical binding]; other site 1286640006220 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640006221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640006222 dimer interface [polypeptide binding]; other site 1286640006223 conserved gate region; other site 1286640006224 putative PBP binding loops; other site 1286640006225 ABC-ATPase subunit interface; other site 1286640006226 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640006227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640006228 dimer interface [polypeptide binding]; other site 1286640006229 conserved gate region; other site 1286640006230 putative PBP binding loops; other site 1286640006231 ABC-ATPase subunit interface; other site 1286640006232 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 1286640006233 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1286640006234 active site 1286640006235 catalytic site [active] 1286640006236 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640006237 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640006238 Walker A/P-loop; other site 1286640006239 ATP binding site [chemical binding]; other site 1286640006240 Q-loop/lid; other site 1286640006241 ABC transporter signature motif; other site 1286640006242 Walker B; other site 1286640006243 D-loop; other site 1286640006244 H-loop/switch region; other site 1286640006245 TOBE domain; Region: TOBE_2; pfam08402 1286640006246 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1286640006247 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1286640006248 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286640006249 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1286640006250 phosphogluconate dehydratase; Validated; Region: PRK09054 1286640006251 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1286640006252 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1286640006253 putative active site [active] 1286640006254 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1286640006255 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1286640006256 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1286640006257 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286640006258 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640006259 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1286640006260 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1286640006261 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1286640006262 Predicted flavoproteins [General function prediction only]; Region: COG2081 1286640006263 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640006264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286640006265 dimerization interface [polypeptide binding]; other site 1286640006266 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286640006267 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286640006268 dimer interface [polypeptide binding]; other site 1286640006269 putative CheW interface [polypeptide binding]; other site 1286640006270 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640006271 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640006272 isocitrate lyase; Provisional; Region: PRK15063 1286640006273 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1286640006274 tetramer interface [polypeptide binding]; other site 1286640006275 active site 1286640006276 Mg2+/Mn2+ binding site [ion binding]; other site 1286640006277 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286640006278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640006279 non-specific DNA binding site [nucleotide binding]; other site 1286640006280 salt bridge; other site 1286640006281 sequence-specific DNA binding site [nucleotide binding]; other site 1286640006282 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1286640006283 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1286640006284 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1286640006285 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1286640006286 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286640006287 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286640006288 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1286640006289 Walker A/P-loop; other site 1286640006290 ATP binding site [chemical binding]; other site 1286640006291 Q-loop/lid; other site 1286640006292 ABC transporter signature motif; other site 1286640006293 Walker B; other site 1286640006294 D-loop; other site 1286640006295 H-loop/switch region; other site 1286640006296 TOBE domain; Region: TOBE_2; pfam08402 1286640006297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640006298 dimer interface [polypeptide binding]; other site 1286640006299 conserved gate region; other site 1286640006300 putative PBP binding loops; other site 1286640006301 ABC-ATPase subunit interface; other site 1286640006302 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640006303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640006304 dimer interface [polypeptide binding]; other site 1286640006305 conserved gate region; other site 1286640006306 putative PBP binding loops; other site 1286640006307 ABC-ATPase subunit interface; other site 1286640006308 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1286640006309 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1286640006310 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1286640006311 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1286640006312 acyl-activating enzyme (AAE) consensus motif; other site 1286640006313 putative AMP binding site [chemical binding]; other site 1286640006314 putative active site [active] 1286640006315 putative CoA binding site [chemical binding]; other site 1286640006316 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286640006317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640006318 dimer interface [polypeptide binding]; other site 1286640006319 conserved gate region; other site 1286640006320 putative PBP binding loops; other site 1286640006321 ABC-ATPase subunit interface; other site 1286640006322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640006323 dimer interface [polypeptide binding]; other site 1286640006324 conserved gate region; other site 1286640006325 putative PBP binding loops; other site 1286640006326 ABC-ATPase subunit interface; other site 1286640006327 PAS domain S-box; Region: sensory_box; TIGR00229 1286640006328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640006329 putative active site [active] 1286640006330 heme pocket [chemical binding]; other site 1286640006331 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640006332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640006333 dimer interface [polypeptide binding]; other site 1286640006334 phosphorylation site [posttranslational modification] 1286640006335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640006336 ATP binding site [chemical binding]; other site 1286640006337 Mg2+ binding site [ion binding]; other site 1286640006338 G-X-G motif; other site 1286640006339 Uncharacterized conserved protein [Function unknown]; Region: COG5490 1286640006340 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1286640006341 classical (c) SDRs; Region: SDR_c; cd05233 1286640006342 NAD(P) binding site [chemical binding]; other site 1286640006343 active site 1286640006344 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1286640006345 FAD binding domain; Region: FAD_binding_4; pfam01565 1286640006346 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1286640006347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640006348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640006349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640006350 dimerization interface [polypeptide binding]; other site 1286640006351 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1286640006352 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1286640006353 tetrameric interface [polypeptide binding]; other site 1286640006354 NAD binding site [chemical binding]; other site 1286640006355 catalytic residues [active] 1286640006356 Predicted membrane protein [Function unknown]; Region: COG4269 1286640006357 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1286640006358 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1286640006359 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286640006360 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 1286640006361 Rrf2 family protein; Region: rrf2_super; TIGR00738 1286640006362 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640006363 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1286640006364 peptide binding site [polypeptide binding]; other site 1286640006365 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640006366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640006367 dimer interface [polypeptide binding]; other site 1286640006368 conserved gate region; other site 1286640006369 putative PBP binding loops; other site 1286640006370 ABC-ATPase subunit interface; other site 1286640006371 dipeptide transporter; Provisional; Region: PRK10913 1286640006372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640006373 dimer interface [polypeptide binding]; other site 1286640006374 conserved gate region; other site 1286640006375 putative PBP binding loops; other site 1286640006376 ABC-ATPase subunit interface; other site 1286640006377 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640006378 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1286640006379 Walker A/P-loop; other site 1286640006380 ATP binding site [chemical binding]; other site 1286640006381 Q-loop/lid; other site 1286640006382 ABC transporter signature motif; other site 1286640006383 Walker B; other site 1286640006384 D-loop; other site 1286640006385 H-loop/switch region; other site 1286640006386 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640006387 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640006388 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1286640006389 Walker A/P-loop; other site 1286640006390 ATP binding site [chemical binding]; other site 1286640006391 Q-loop/lid; other site 1286640006392 ABC transporter signature motif; other site 1286640006393 Walker B; other site 1286640006394 D-loop; other site 1286640006395 H-loop/switch region; other site 1286640006396 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640006397 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1286640006398 homotrimer interaction site [polypeptide binding]; other site 1286640006399 putative active site [active] 1286640006400 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1286640006401 two-component response regulator; Provisional; Region: PRK09191 1286640006402 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1286640006403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640006404 active site 1286640006405 phosphorylation site [posttranslational modification] 1286640006406 intermolecular recognition site; other site 1286640006407 dimerization interface [polypeptide binding]; other site 1286640006408 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640006409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286640006410 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640006411 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1286640006412 MgtC family; Region: MgtC; pfam02308 1286640006413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 1286640006414 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1286640006415 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1286640006416 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1286640006417 Chromate transporter; Region: Chromate_transp; pfam02417 1286640006418 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1286640006419 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1286640006420 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1286640006421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640006422 S-adenosylmethionine binding site [chemical binding]; other site 1286640006423 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1286640006424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640006425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286640006426 putative substrate translocation pore; other site 1286640006427 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1286640006428 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1286640006429 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1286640006430 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1286640006431 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1286640006432 active site 1286640006433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5331 1286640006434 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1286640006435 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1286640006436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640006437 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1286640006438 dimerization interface [polypeptide binding]; other site 1286640006439 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1286640006440 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1286640006441 tetramer interface [polypeptide binding]; other site 1286640006442 heme binding pocket [chemical binding]; other site 1286640006443 NADPH binding site [chemical binding]; other site 1286640006444 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1286640006445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640006446 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640006447 dimerization interface [polypeptide binding]; other site 1286640006448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 1286640006449 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640006450 non-specific DNA binding site [nucleotide binding]; other site 1286640006451 salt bridge; other site 1286640006452 sequence-specific DNA binding site [nucleotide binding]; other site 1286640006453 Uncharacterized conserved protein [Function unknown]; Region: COG5403 1286640006454 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 1286640006455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1286640006456 RNA methyltransferase, RsmE family; Region: TIGR00046 1286640006457 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1286640006458 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1286640006459 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 1286640006460 nudix motif; other site 1286640006461 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640006462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640006463 DNA-binding site [nucleotide binding]; DNA binding site 1286640006464 FCD domain; Region: FCD; pfam07729 1286640006465 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4949 1286640006466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640006467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640006468 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640006469 putative effector binding pocket; other site 1286640006470 dimerization interface [polypeptide binding]; other site 1286640006471 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1286640006472 FAD binding domain; Region: FAD_binding_4; pfam01565 1286640006473 FAD binding domain; Region: FAD_binding_4; pfam01565 1286640006474 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1286640006475 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1286640006476 Cysteine-rich domain; Region: CCG; pfam02754 1286640006477 Cysteine-rich domain; Region: CCG; pfam02754 1286640006478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1286640006479 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286640006480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1286640006481 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286640006482 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1286640006483 Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953 1286640006484 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1286640006485 Na binding site [ion binding]; other site 1286640006486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 1286640006487 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 1286640006488 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1286640006489 dimer interface [polypeptide binding]; other site 1286640006490 motif 1; other site 1286640006491 active site 1286640006492 motif 2; other site 1286640006493 motif 3; other site 1286640006494 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1286640006495 anticodon binding site; other site 1286640006496 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 1286640006497 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1286640006498 motif 1; other site 1286640006499 dimer interface [polypeptide binding]; other site 1286640006500 active site 1286640006501 motif 2; other site 1286640006502 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1286640006503 motif 3; other site 1286640006504 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1286640006505 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 1286640006506 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1286640006507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286640006508 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640006509 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1286640006510 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1286640006511 ring oligomerisation interface [polypeptide binding]; other site 1286640006512 ATP/Mg binding site [chemical binding]; other site 1286640006513 stacking interactions; other site 1286640006514 hinge regions; other site 1286640006515 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1286640006516 oligomerisation interface [polypeptide binding]; other site 1286640006517 mobile loop; other site 1286640006518 roof hairpin; other site 1286640006519 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1286640006520 active site residue [active] 1286640006521 Uncharacterized conserved protein [Function unknown]; Region: COG4275 1286640006522 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1286640006523 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1286640006524 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1286640006525 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1286640006526 active site 1286640006527 Riboflavin kinase; Region: Flavokinase; smart00904 1286640006528 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 1286640006529 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1286640006530 active site 1286640006531 HIGH motif; other site 1286640006532 nucleotide binding site [chemical binding]; other site 1286640006533 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1286640006534 active site 1286640006535 KMSKS motif; other site 1286640006536 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1286640006537 tRNA binding surface [nucleotide binding]; other site 1286640006538 anticodon binding site; other site 1286640006539 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1286640006540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640006541 Coenzyme A binding pocket [chemical binding]; other site 1286640006542 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1286640006543 nucleoside/Zn binding site; other site 1286640006544 dimer interface [polypeptide binding]; other site 1286640006545 catalytic motif [active] 1286640006546 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1286640006547 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286640006548 RNA binding surface [nucleotide binding]; other site 1286640006549 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1286640006550 active site 1286640006551 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1286640006552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640006553 S-adenosylmethionine binding site [chemical binding]; other site 1286640006554 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1286640006555 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1286640006556 nucleophile elbow; other site 1286640006557 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1286640006558 putative active site [active] 1286640006559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1286640006560 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1286640006561 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1286640006562 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1286640006563 TrkA-N domain; Region: TrkA_N; pfam02254 1286640006564 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1286640006565 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1286640006566 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1286640006567 active site 1286640006568 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 1286640006569 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 1286640006570 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1286640006571 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1286640006572 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1286640006573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640006574 motif II; other site 1286640006575 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1286640006576 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1286640006577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1286640006578 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640006579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 1286640006580 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1286640006581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640006582 ATP binding site [chemical binding]; other site 1286640006583 Mg2+ binding site [ion binding]; other site 1286640006584 G-X-G motif; other site 1286640006585 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1286640006586 ATP binding site [chemical binding]; other site 1286640006587 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1286640006588 PAS fold; Region: PAS_4; pfam08448 1286640006589 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640006590 putative active site [active] 1286640006591 heme pocket [chemical binding]; other site 1286640006592 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640006593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640006594 active site 1286640006595 phosphorylation site [posttranslational modification] 1286640006596 intermolecular recognition site; other site 1286640006597 dimerization interface [polypeptide binding]; other site 1286640006598 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640006599 metal binding site [ion binding]; metal-binding site 1286640006600 active site 1286640006601 I-site; other site 1286640006602 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640006603 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286640006604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640006605 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1286640006606 dimerization interface [polypeptide binding]; other site 1286640006607 substrate binding pocket [chemical binding]; other site 1286640006608 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 1286640006609 PRC-barrel domain; Region: PRC; pfam05239 1286640006610 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1286640006611 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1286640006612 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1286640006613 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1286640006614 active site 1286640006615 intersubunit interface [polypeptide binding]; other site 1286640006616 catalytic residue [active] 1286640006617 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1286640006618 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1286640006619 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640006620 classical (c) SDRs; Region: SDR_c; cd05233 1286640006621 NAD(P) binding site [chemical binding]; other site 1286640006622 active site 1286640006623 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286640006624 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286640006625 transcriptional regulator TraR; Provisional; Region: PRK13870 1286640006626 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1286640006627 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640006628 DNA binding residues [nucleotide binding] 1286640006629 dimerization interface [polypeptide binding]; other site 1286640006630 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 1286640006631 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1286640006632 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640006633 DNA binding residues [nucleotide binding] 1286640006634 dimerization interface [polypeptide binding]; other site 1286640006635 Domain of unknown function DUF59; Region: DUF59; pfam01883 1286640006636 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1286640006637 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1286640006638 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1286640006639 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 1286640006640 Cl binding site [ion binding]; other site 1286640006641 oligomer interface [polypeptide binding]; other site 1286640006642 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1286640006643 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1286640006644 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1286640006645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 1286640006646 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1286640006647 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1286640006648 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 1286640006649 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 1286640006650 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1286640006651 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 1286640006652 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 1286640006653 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1286640006654 RNA/DNA hybrid binding site [nucleotide binding]; other site 1286640006655 active site 1286640006656 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1286640006657 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286640006658 FeS/SAM binding site; other site 1286640006659 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286640006660 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286640006661 active site 1286640006662 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1286640006663 MPT binding site; other site 1286640006664 trimer interface [polypeptide binding]; other site 1286640006665 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 1286640006666 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1286640006667 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1286640006668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640006669 TPR motif; other site 1286640006670 binding surface 1286640006671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640006672 binding surface 1286640006673 TPR motif; other site 1286640006674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640006675 binding surface 1286640006676 TPR motif; other site 1286640006677 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1286640006678 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1286640006679 substrate binding pocket [chemical binding]; other site 1286640006680 chain length determination region; other site 1286640006681 substrate-Mg2+ binding site; other site 1286640006682 catalytic residues [active] 1286640006683 aspartate-rich region 1; other site 1286640006684 active site lid residues [active] 1286640006685 aspartate-rich region 2; other site 1286640006686 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1286640006687 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1286640006688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640006689 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1286640006690 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1286640006691 tandem repeat interface [polypeptide binding]; other site 1286640006692 oligomer interface [polypeptide binding]; other site 1286640006693 active site residues [active] 1286640006694 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1286640006695 dimer interface [polypeptide binding]; other site 1286640006696 motif 1; other site 1286640006697 active site 1286640006698 motif 2; other site 1286640006699 motif 3; other site 1286640006700 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1286640006701 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1286640006702 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 1286640006703 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1286640006704 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1286640006705 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1286640006706 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1286640006707 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1286640006708 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1286640006709 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1286640006710 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640006711 metal binding site [ion binding]; metal-binding site 1286640006712 active site 1286640006713 I-site; other site 1286640006714 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640006715 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1286640006716 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286640006717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640006718 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286640006719 putative substrate translocation pore; other site 1286640006720 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286640006721 Helix-turn-helix domain; Region: HTH_18; pfam12833 1286640006722 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1286640006723 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 1286640006724 UbiA prenyltransferase family; Region: UbiA; pfam01040 1286640006725 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1286640006726 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1286640006727 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1286640006728 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1286640006729 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1286640006730 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1286640006731 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286640006732 FAD binding domain; Region: FAD_binding_4; pfam01565 1286640006733 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1286640006734 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1286640006735 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1286640006736 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1286640006737 [2Fe-2S] cluster binding site [ion binding]; other site 1286640006738 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1286640006739 putative alpha subunit interface [polypeptide binding]; other site 1286640006740 putative active site [active] 1286640006741 putative substrate binding site [chemical binding]; other site 1286640006742 Fe binding site [ion binding]; other site 1286640006743 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1286640006744 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1286640006745 FAD binding pocket [chemical binding]; other site 1286640006746 FAD binding motif [chemical binding]; other site 1286640006747 phosphate binding motif [ion binding]; other site 1286640006748 beta-alpha-beta structure motif; other site 1286640006749 NAD binding pocket [chemical binding]; other site 1286640006750 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640006751 catalytic loop [active] 1286640006752 iron binding site [ion binding]; other site 1286640006753 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1286640006754 active site 1286640006755 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1286640006756 BA14K-like protein; Region: BA14K; pfam07886 1286640006757 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1286640006758 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1286640006759 Cl binding site [ion binding]; other site 1286640006760 oligomer interface [polypeptide binding]; other site 1286640006761 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286640006762 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286640006763 active site 1286640006764 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1286640006765 enoyl-CoA hydratase; Provisional; Region: PRK06688 1286640006766 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286640006767 substrate binding site [chemical binding]; other site 1286640006768 oxyanion hole (OAH) forming residues; other site 1286640006769 trimer interface [polypeptide binding]; other site 1286640006770 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1286640006771 Cache domain; Region: Cache_1; pfam02743 1286640006772 HAMP domain; Region: HAMP; pfam00672 1286640006773 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286640006774 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286640006775 dimer interface [polypeptide binding]; other site 1286640006776 putative CheW interface [polypeptide binding]; other site 1286640006777 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1286640006778 TRAM domain; Region: TRAM; cl01282 1286640006779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640006780 S-adenosylmethionine binding site [chemical binding]; other site 1286640006781 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1286640006782 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286640006783 RNA binding surface [nucleotide binding]; other site 1286640006784 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1286640006785 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1286640006786 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1286640006787 TPP-binding site; other site 1286640006788 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1286640006789 PYR/PP interface [polypeptide binding]; other site 1286640006790 dimer interface [polypeptide binding]; other site 1286640006791 TPP binding site [chemical binding]; other site 1286640006792 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286640006793 Pirin-related protein [General function prediction only]; Region: COG1741 1286640006794 Pirin; Region: Pirin; pfam02678 1286640006795 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1286640006796 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1286640006797 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1286640006798 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1286640006799 putative active site [active] 1286640006800 Zn binding site [ion binding]; other site 1286640006801 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286640006802 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 1286640006803 NADP binding site [chemical binding]; other site 1286640006804 dimer interface [polypeptide binding]; other site 1286640006805 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1286640006806 active site 1286640006807 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286640006808 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1286640006809 dimer interface [polypeptide binding]; other site 1286640006810 active site 1286640006811 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1286640006812 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286640006813 acyl-activating enzyme (AAE) consensus motif; other site 1286640006814 AMP binding site [chemical binding]; other site 1286640006815 active site 1286640006816 CoA binding site [chemical binding]; other site 1286640006817 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1286640006818 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1286640006819 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1286640006820 Walker A/P-loop; other site 1286640006821 ATP binding site [chemical binding]; other site 1286640006822 Q-loop/lid; other site 1286640006823 ABC transporter signature motif; other site 1286640006824 Walker B; other site 1286640006825 D-loop; other site 1286640006826 H-loop/switch region; other site 1286640006827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1286640006828 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1286640006829 protease TldD; Provisional; Region: tldD; PRK10735 1286640006830 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286640006831 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1286640006832 Sporulation related domain; Region: SPOR; pfam05036 1286640006833 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1286640006834 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 1286640006835 putative active site [active] 1286640006836 putative metal binding site [ion binding]; other site 1286640006837 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1286640006838 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1286640006839 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1286640006840 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1286640006841 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1286640006842 HSP70 interaction site [polypeptide binding]; other site 1286640006843 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1286640006844 substrate binding site [polypeptide binding]; other site 1286640006845 dimer interface [polypeptide binding]; other site 1286640006846 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 1286640006847 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1286640006848 NAD binding site [chemical binding]; other site 1286640006849 homotetramer interface [polypeptide binding]; other site 1286640006850 homodimer interface [polypeptide binding]; other site 1286640006851 substrate binding site [chemical binding]; other site 1286640006852 active site 1286640006853 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286640006854 catalytic core [active] 1286640006855 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 1286640006856 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1286640006857 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1286640006858 Tetramer interface [polypeptide binding]; other site 1286640006859 active site 1286640006860 FMN-binding site [chemical binding]; other site 1286640006861 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1286640006862 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1286640006863 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1286640006864 dimerization interface [polypeptide binding]; other site 1286640006865 active site 1286640006866 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 1286640006867 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00051 1286640006868 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1286640006869 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1286640006870 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 1286640006871 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1286640006872 Subunit I/III interface [polypeptide binding]; other site 1286640006873 D-pathway; other site 1286640006874 Subunit I/VIIc interface [polypeptide binding]; other site 1286640006875 Subunit I/IV interface [polypeptide binding]; other site 1286640006876 Subunit I/II interface [polypeptide binding]; other site 1286640006877 Low-spin heme (heme a) binding site [chemical binding]; other site 1286640006878 Subunit I/VIIa interface [polypeptide binding]; other site 1286640006879 Subunit I/VIa interface [polypeptide binding]; other site 1286640006880 Dimer interface; other site 1286640006881 Putative water exit pathway; other site 1286640006882 Binuclear center (heme a3/CuB) [ion binding]; other site 1286640006883 K-pathway; other site 1286640006884 Subunit I/Vb interface [polypeptide binding]; other site 1286640006885 Putative proton exit pathway; other site 1286640006886 Subunit I/VIb interface; other site 1286640006887 Subunit I/VIc interface [polypeptide binding]; other site 1286640006888 Electron transfer pathway; other site 1286640006889 Subunit I/VIIIb interface [polypeptide binding]; other site 1286640006890 Subunit I/VIIb interface [polypeptide binding]; other site 1286640006891 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1286640006892 UbiA prenyltransferase family; Region: UbiA; pfam01040 1286640006893 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 1286640006894 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1286640006895 Subunit III/VIIa interface [polypeptide binding]; other site 1286640006896 Phospholipid binding site [chemical binding]; other site 1286640006897 Subunit I/III interface [polypeptide binding]; other site 1286640006898 Subunit III/VIb interface [polypeptide binding]; other site 1286640006899 Subunit III/VIa interface; other site 1286640006900 Subunit III/Vb interface [polypeptide binding]; other site 1286640006901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 1286640006902 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1286640006903 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1286640006904 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1286640006905 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1286640006906 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1286640006907 putative active site [active] 1286640006908 putative substrate binding site [chemical binding]; other site 1286640006909 ATP binding site [chemical binding]; other site 1286640006910 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1286640006911 RNA/DNA hybrid binding site [nucleotide binding]; other site 1286640006912 active site 1286640006913 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1286640006914 catalytic triad [active] 1286640006915 dimer interface [polypeptide binding]; other site 1286640006916 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 1286640006917 hypothetical protein; Validated; Region: PRK00228 1286640006918 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1286640006919 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1286640006920 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640006921 PAS fold; Region: PAS_3; pfam08447 1286640006922 putative active site [active] 1286640006923 heme pocket [chemical binding]; other site 1286640006924 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286640006925 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640006926 metal binding site [ion binding]; metal-binding site 1286640006927 active site 1286640006928 I-site; other site 1286640006929 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640006930 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286640006931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286640006932 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1286640006933 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1286640006934 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1286640006935 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1286640006936 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1286640006937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640006938 catalytic residue [active] 1286640006939 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1286640006940 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1286640006941 dimerization interface [polypeptide binding]; other site 1286640006942 ligand binding site [chemical binding]; other site 1286640006943 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1286640006944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640006945 motif II; other site 1286640006946 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640006947 dimerization interface [polypeptide binding]; other site 1286640006948 putative DNA binding site [nucleotide binding]; other site 1286640006949 putative Zn2+ binding site [ion binding]; other site 1286640006950 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1286640006951 DNA methylase; Region: N6_N4_Mtase; pfam01555 1286640006952 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1286640006953 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1286640006954 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1286640006955 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1286640006956 minor groove reading motif; other site 1286640006957 helix-hairpin-helix signature motif; other site 1286640006958 substrate binding pocket [chemical binding]; other site 1286640006959 active site 1286640006960 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1286640006961 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1286640006962 DNA binding and oxoG recognition site [nucleotide binding] 1286640006963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 1286640006964 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1286640006965 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1286640006966 catalytic residues [active] 1286640006967 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1286640006968 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1286640006969 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1286640006970 Walker A/P-loop; other site 1286640006971 ATP binding site [chemical binding]; other site 1286640006972 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1286640006973 ABC transporter signature motif; other site 1286640006974 Walker B; other site 1286640006975 D-loop; other site 1286640006976 H-loop/switch region; other site 1286640006977 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1286640006978 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1286640006979 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1286640006980 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1286640006981 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 1286640006982 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286640006983 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1286640006984 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 1286640006985 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286640006986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640006987 non-specific DNA binding site [nucleotide binding]; other site 1286640006988 salt bridge; other site 1286640006989 sequence-specific DNA binding site [nucleotide binding]; other site 1286640006990 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1286640006991 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1286640006992 CysD dimerization site [polypeptide binding]; other site 1286640006993 G1 box; other site 1286640006994 putative GEF interaction site [polypeptide binding]; other site 1286640006995 GTP/Mg2+ binding site [chemical binding]; other site 1286640006996 Switch I region; other site 1286640006997 G2 box; other site 1286640006998 G3 box; other site 1286640006999 Switch II region; other site 1286640007000 G4 box; other site 1286640007001 G5 box; other site 1286640007002 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1286640007003 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1286640007004 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1286640007005 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1286640007006 Active Sites [active] 1286640007007 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1286640007008 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1286640007009 Active Sites [active] 1286640007010 choline dehydrogenase; Validated; Region: PRK02106 1286640007011 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1286640007012 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1286640007013 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1286640007014 NAD(P) binding site [chemical binding]; other site 1286640007015 catalytic residues [active] 1286640007016 Sulfatase; Region: Sulfatase; cl17466 1286640007017 choline-sulfatase; Region: chol_sulfatase; TIGR03417 1286640007018 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 1286640007019 transcriptional regulator BetI; Validated; Region: PRK00767 1286640007020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640007021 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1286640007022 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1286640007023 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640007024 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1286640007025 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286640007026 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640007027 metal binding site [ion binding]; metal-binding site 1286640007028 active site 1286640007029 I-site; other site 1286640007030 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1286640007031 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1286640007032 NAD(P) binding site [chemical binding]; other site 1286640007033 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 1286640007034 L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448 1286640007035 glutathionine S-transferase; Provisional; Region: PRK10542 1286640007036 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1286640007037 C-terminal domain interface [polypeptide binding]; other site 1286640007038 GSH binding site (G-site) [chemical binding]; other site 1286640007039 dimer interface [polypeptide binding]; other site 1286640007040 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1286640007041 dimer interface [polypeptide binding]; other site 1286640007042 N-terminal domain interface [polypeptide binding]; other site 1286640007043 substrate binding pocket (H-site) [chemical binding]; other site 1286640007044 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286640007045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640007046 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1286640007047 dimerization interface [polypeptide binding]; other site 1286640007048 substrate binding pocket [chemical binding]; other site 1286640007049 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640007050 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1286640007051 putative C-terminal domain interface [polypeptide binding]; other site 1286640007052 putative GSH binding site (G-site) [chemical binding]; other site 1286640007053 putative dimer interface [polypeptide binding]; other site 1286640007054 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1286640007055 dimer interface [polypeptide binding]; other site 1286640007056 N-terminal domain interface [polypeptide binding]; other site 1286640007057 putative substrate binding pocket (H-site) [chemical binding]; other site 1286640007058 PAS fold; Region: PAS_4; pfam08448 1286640007059 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1286640007060 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1286640007061 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286640007062 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640007063 metal binding site [ion binding]; metal-binding site 1286640007064 active site 1286640007065 I-site; other site 1286640007066 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640007067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1286640007068 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286640007069 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286640007070 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640007071 putative Zn2+ binding site [ion binding]; other site 1286640007072 putative DNA binding site [nucleotide binding]; other site 1286640007073 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1286640007074 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1286640007075 PhnA protein; Region: PhnA; pfam03831 1286640007076 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1286640007077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1286640007078 Walker A motif; other site 1286640007079 ATP binding site [chemical binding]; other site 1286640007080 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640007081 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640007082 active site 1286640007083 catalytic tetrad [active] 1286640007084 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1286640007085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640007086 S-adenosylmethionine binding site [chemical binding]; other site 1286640007087 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1286640007088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640007089 motif II; other site 1286640007090 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 1286640007091 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1286640007092 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1286640007093 putative NAD(P) binding site [chemical binding]; other site 1286640007094 catalytic Zn binding site [ion binding]; other site 1286640007095 structural Zn binding site [ion binding]; other site 1286640007096 aminotransferase; Provisional; Region: PRK13356 1286640007097 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1286640007098 homodimer interface [polypeptide binding]; other site 1286640007099 substrate-cofactor binding pocket; other site 1286640007100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640007101 catalytic residue [active] 1286640007102 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1286640007103 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640007104 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1286640007105 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1286640007106 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1286640007107 Predicted transcriptional regulator [Transcription]; Region: COG2378 1286640007108 HTH domain; Region: HTH_11; pfam08279 1286640007109 WYL domain; Region: WYL; pfam13280 1286640007110 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286640007111 Cytochrome c556 [Energy production and conversion]; Region: COG3909 1286640007112 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286640007113 Cytochrome c; Region: Cytochrom_C; cl11414 1286640007114 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286640007115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640007116 Coenzyme A binding pocket [chemical binding]; other site 1286640007117 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 1286640007118 DNA binding residues [nucleotide binding] 1286640007119 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1286640007120 dimer interface [polypeptide binding]; other site 1286640007121 putative metal binding site [ion binding]; other site 1286640007122 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1286640007123 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1286640007124 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1286640007125 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1286640007126 Trp docking motif [polypeptide binding]; other site 1286640007127 putative active site [active] 1286640007128 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1286640007129 hypothetical protein; Validated; Region: PRK00029 1286640007130 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 1286640007131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1286640007132 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1286640007133 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286640007134 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1286640007135 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1286640007136 putative metal binding site [ion binding]; other site 1286640007137 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286640007138 active site 1286640007139 metal binding site [ion binding]; metal-binding site 1286640007140 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286640007141 Ligand Binding Site [chemical binding]; other site 1286640007142 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1286640007143 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1286640007144 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1286640007145 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1286640007146 SelR domain; Region: SelR; pfam01641 1286640007147 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 1286640007148 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1286640007149 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286640007150 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1286640007151 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1286640007152 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658 1286640007153 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 1286640007154 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286640007155 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1286640007156 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 1286640007157 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 1286640007158 Predicted transcriptional regulator [Transcription]; Region: COG4957 1286640007159 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1286640007160 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1286640007161 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640007162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640007163 dimer interface [polypeptide binding]; other site 1286640007164 phosphorylation site [posttranslational modification] 1286640007165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640007166 ATP binding site [chemical binding]; other site 1286640007167 Mg2+ binding site [ion binding]; other site 1286640007168 G-X-G motif; other site 1286640007169 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1286640007170 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640007171 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640007172 Uncharacterized conserved protein [Function unknown]; Region: COG5447 1286640007173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 1286640007174 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1286640007175 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1286640007176 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286640007177 Predicted integral membrane protein [Function unknown]; Region: COG5436 1286640007178 Uncharacterized conserved protein [Function unknown]; Region: COG5402 1286640007179 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1286640007180 Transglycosylase; Region: Transgly; pfam00912 1286640007181 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1286640007182 hypothetical protein; Provisional; Region: PRK05170 1286640007183 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1286640007184 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640007185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640007186 active site 1286640007187 phosphorylation site [posttranslational modification] 1286640007188 intermolecular recognition site; other site 1286640007189 dimerization interface [polypeptide binding]; other site 1286640007190 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640007191 DNA binding site [nucleotide binding] 1286640007192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640007193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640007194 ATP binding site [chemical binding]; other site 1286640007195 Mg2+ binding site [ion binding]; other site 1286640007196 G-X-G motif; other site 1286640007197 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 1286640007198 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1286640007199 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1286640007200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640007201 binding surface 1286640007202 TPR motif; other site 1286640007203 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1286640007204 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1286640007205 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1286640007206 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1286640007207 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286640007208 protein binding site [polypeptide binding]; other site 1286640007209 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286640007210 protein binding site [polypeptide binding]; other site 1286640007211 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640007212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640007213 active site 1286640007214 phosphorylation site [posttranslational modification] 1286640007215 intermolecular recognition site; other site 1286640007216 dimerization interface [polypeptide binding]; other site 1286640007217 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640007218 DNA binding site [nucleotide binding] 1286640007219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640007220 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286640007221 dimerization interface [polypeptide binding]; other site 1286640007222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640007223 dimer interface [polypeptide binding]; other site 1286640007224 phosphorylation site [posttranslational modification] 1286640007225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640007226 ATP binding site [chemical binding]; other site 1286640007227 Mg2+ binding site [ion binding]; other site 1286640007228 G-X-G motif; other site 1286640007229 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 1286640007230 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1286640007231 metal binding triad; other site 1286640007232 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1286640007233 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1286640007234 metal binding triad; other site 1286640007235 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640007236 PAS fold; Region: PAS_3; pfam08447 1286640007237 putative active site [active] 1286640007238 heme pocket [chemical binding]; other site 1286640007239 PAS fold; Region: PAS_7; pfam12860 1286640007240 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640007241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640007242 dimer interface [polypeptide binding]; other site 1286640007243 phosphorylation site [posttranslational modification] 1286640007244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640007245 ATP binding site [chemical binding]; other site 1286640007246 Mg2+ binding site [ion binding]; other site 1286640007247 G-X-G motif; other site 1286640007248 aminopeptidase N; Provisional; Region: pepN; PRK14015 1286640007249 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1286640007250 active site 1286640007251 Zn binding site [ion binding]; other site 1286640007252 EamA-like transporter family; Region: EamA; pfam00892 1286640007253 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286640007254 EamA-like transporter family; Region: EamA; pfam00892 1286640007255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640007256 putative MFS family transporter protein; Provisional; Region: PRK03633 1286640007257 putative substrate translocation pore; other site 1286640007258 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1286640007259 Fe-S cluster binding site [ion binding]; other site 1286640007260 active site 1286640007261 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1286640007262 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1286640007263 nucleotide binding site [chemical binding]; other site 1286640007264 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1286640007265 SBD interface [polypeptide binding]; other site 1286640007266 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1286640007267 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640007268 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1286640007269 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1286640007270 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1286640007271 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286640007272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640007273 dimer interface [polypeptide binding]; other site 1286640007274 conserved gate region; other site 1286640007275 putative PBP binding loops; other site 1286640007276 ABC-ATPase subunit interface; other site 1286640007277 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1286640007278 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1286640007279 putative NAD(P) binding site [chemical binding]; other site 1286640007280 dimer interface [polypeptide binding]; other site 1286640007281 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286640007282 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286640007283 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1286640007284 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1286640007285 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1286640007286 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1286640007287 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286640007288 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1286640007289 Ligand binding site; other site 1286640007290 Putative Catalytic site; other site 1286640007291 DXD motif; other site 1286640007292 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1286640007293 AMP nucleosidase; Provisional; Region: PRK08292 1286640007294 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1286640007295 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1286640007296 Uncharacterized conserved protein [Function unknown]; Region: COG1742 1286640007297 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1286640007298 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1286640007299 C-terminal domain interface [polypeptide binding]; other site 1286640007300 GSH binding site (G-site) [chemical binding]; other site 1286640007301 dimer interface [polypeptide binding]; other site 1286640007302 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1286640007303 N-terminal domain interface [polypeptide binding]; other site 1286640007304 putative dimer interface [polypeptide binding]; other site 1286640007305 active site 1286640007306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 1286640007307 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1286640007308 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 1286640007309 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640007310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640007311 homodimer interface [polypeptide binding]; other site 1286640007312 catalytic residue [active] 1286640007313 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1286640007314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640007315 sequence-specific DNA binding site [nucleotide binding]; other site 1286640007316 salt bridge; other site 1286640007317 Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549 1286640007318 Porin subfamily; Region: Porin_2; pfam02530 1286640007319 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1286640007320 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286640007321 active site 1286640007322 DNA binding site [nucleotide binding] 1286640007323 Int/Topo IB signature motif; other site 1286640007324 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1286640007325 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640007326 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640007327 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1286640007328 Porin subfamily; Region: Porin_2; pfam02530 1286640007329 BA14K-like protein; Region: BA14K; pfam07886 1286640007330 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1286640007331 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286640007332 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286640007333 catalytic residue [active] 1286640007334 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286640007335 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1286640007336 dimer interface [polypeptide binding]; other site 1286640007337 active site 1286640007338 catalytic residue [active] 1286640007339 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1286640007340 SmpB-tmRNA interface; other site 1286640007341 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1286640007342 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 1286640007343 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1286640007344 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1286640007345 LabA_like proteins; Region: LabA; cd10911 1286640007346 putative metal binding site [ion binding]; other site 1286640007347 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1286640007348 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1286640007349 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286640007350 Zn2+ binding site [ion binding]; other site 1286640007351 Mg2+ binding site [ion binding]; other site 1286640007352 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1286640007353 synthetase active site [active] 1286640007354 NTP binding site [chemical binding]; other site 1286640007355 metal binding site [ion binding]; metal-binding site 1286640007356 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1286640007357 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1286640007358 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1286640007359 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1286640007360 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 1286640007361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 1286640007362 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1286640007363 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1286640007364 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1286640007365 Catalytic site [active] 1286640007366 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1286640007367 ribonuclease III; Reviewed; Region: PRK12371 1286640007368 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1286640007369 dimerization interface [polypeptide binding]; other site 1286640007370 active site 1286640007371 metal binding site [ion binding]; metal-binding site 1286640007372 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1286640007373 dsRNA binding site [nucleotide binding]; other site 1286640007374 GTPase Era; Reviewed; Region: era; PRK00089 1286640007375 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1286640007376 G1 box; other site 1286640007377 GTP/Mg2+ binding site [chemical binding]; other site 1286640007378 Switch I region; other site 1286640007379 G2 box; other site 1286640007380 Switch II region; other site 1286640007381 G3 box; other site 1286640007382 G4 box; other site 1286640007383 G5 box; other site 1286640007384 KH domain; Region: KH_2; pfam07650 1286640007385 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1286640007386 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286640007387 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1286640007388 ArsC family; Region: ArsC; pfam03960 1286640007389 catalytic residues [active] 1286640007390 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1286640007391 amphipathic channel; other site 1286640007392 Asn-Pro-Ala signature motifs; other site 1286640007393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640007394 dimerization interface [polypeptide binding]; other site 1286640007395 putative DNA binding site [nucleotide binding]; other site 1286640007396 putative Zn2+ binding site [ion binding]; other site 1286640007397 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 1286640007398 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1286640007399 putative active site [active] 1286640007400 catalytic site [active] 1286640007401 putative metal binding site [ion binding]; other site 1286640007402 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1286640007403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640007404 S-adenosylmethionine binding site [chemical binding]; other site 1286640007405 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1286640007406 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1286640007407 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1286640007408 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1286640007409 RNA binding site [nucleotide binding]; other site 1286640007410 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1286640007411 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1286640007412 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1286640007413 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1286640007414 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640007415 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1286640007416 putative NAD(P) binding site [chemical binding]; other site 1286640007417 active site 1286640007418 putative substrate binding site [chemical binding]; other site 1286640007419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640007420 dimerization interface [polypeptide binding]; other site 1286640007421 putative DNA binding site [nucleotide binding]; other site 1286640007422 putative Zn2+ binding site [ion binding]; other site 1286640007423 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1286640007424 hydrophobic ligand binding site; other site 1286640007425 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286640007426 active site 1286640007427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1286640007428 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286640007429 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1286640007430 Recombination protein O N terminal; Region: RecO_N; pfam11967 1286640007431 Recombination protein O C terminal; Region: RecO_C; pfam02565 1286640007432 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1286640007433 Predicted membrane protein [Function unknown]; Region: COG5373 1286640007434 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1286640007435 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286640007436 Zn2+ binding site [ion binding]; other site 1286640007437 Mg2+ binding site [ion binding]; other site 1286640007438 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1286640007439 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1286640007440 MOSC domain; Region: MOSC; pfam03473 1286640007441 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1286640007442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640007443 putative substrate translocation pore; other site 1286640007444 quinolinate synthetase; Provisional; Region: PRK09375 1286640007445 L-aspartate oxidase; Provisional; Region: PRK07512 1286640007446 L-aspartate oxidase; Provisional; Region: PRK06175 1286640007447 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1286640007448 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1286640007449 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1286640007450 dimerization interface [polypeptide binding]; other site 1286640007451 active site 1286640007452 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1286640007453 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1286640007454 E-class dimer interface [polypeptide binding]; other site 1286640007455 P-class dimer interface [polypeptide binding]; other site 1286640007456 active site 1286640007457 Cu2+ binding site [ion binding]; other site 1286640007458 Zn2+ binding site [ion binding]; other site 1286640007459 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 1286640007460 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640007461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640007462 Walker A/P-loop; other site 1286640007463 ATP binding site [chemical binding]; other site 1286640007464 Q-loop/lid; other site 1286640007465 ABC transporter signature motif; other site 1286640007466 Walker B; other site 1286640007467 D-loop; other site 1286640007468 H-loop/switch region; other site 1286640007469 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1286640007470 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640007471 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640007472 ACP:hemolysin acyltransferase (hemolysin-activating protein) [Posttranslational modification, protein turnover, chaperones]; Region: HlyC; COG2994 1286640007473 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1286640007474 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 1286640007475 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 1286640007476 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1286640007477 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1286640007478 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1286640007479 Predicted secreted protein [Function unknown]; Region: COG5451 1286640007480 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 1286640007481 nudix motif; other site 1286640007482 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1286640007483 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1286640007484 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1286640007485 active site 1286640007486 HIGH motif; other site 1286640007487 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1286640007488 KMSKS motif; other site 1286640007489 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1286640007490 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1286640007491 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1286640007492 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1286640007493 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1286640007494 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1286640007495 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1286640007496 active site 1286640007497 catalytic residues [active] 1286640007498 metal binding site [ion binding]; metal-binding site 1286640007499 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1286640007500 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1286640007501 EamA-like transporter family; Region: EamA; cl17759 1286640007502 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1286640007503 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1286640007504 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1286640007505 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286640007506 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640007507 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1286640007508 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 1286640007509 Walker A/P-loop; other site 1286640007510 ATP binding site [chemical binding]; other site 1286640007511 Q-loop/lid; other site 1286640007512 ABC transporter signature motif; other site 1286640007513 Walker B; other site 1286640007514 D-loop; other site 1286640007515 H-loop/switch region; other site 1286640007516 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1286640007517 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1286640007518 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1286640007519 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1286640007520 classical (c) SDRs; Region: SDR_c; cd05233 1286640007521 NAD(P) binding site [chemical binding]; other site 1286640007522 active site 1286640007523 amidophosphoribosyltransferase; Provisional; Region: PRK09123 1286640007524 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1286640007525 active site 1286640007526 tetramer interface [polypeptide binding]; other site 1286640007527 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286640007528 active site 1286640007529 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1286640007530 Colicin V production protein; Region: Colicin_V; pfam02674 1286640007531 DNA repair protein RadA; Provisional; Region: PRK11823 1286640007532 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1286640007533 Walker A motif/ATP binding site; other site 1286640007534 ATP binding site [chemical binding]; other site 1286640007535 Walker B motif; other site 1286640007536 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1286640007537 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1286640007538 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1286640007539 active site 1286640007540 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286640007541 dimer interface [polypeptide binding]; other site 1286640007542 substrate binding site [chemical binding]; other site 1286640007543 catalytic residues [active] 1286640007544 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286640007545 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286640007546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640007547 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640007548 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1286640007549 Predicted membrane protein [Function unknown]; Region: COG4541 1286640007550 replicative DNA helicase; Provisional; Region: PRK09165 1286640007551 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1286640007552 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1286640007553 Walker A motif; other site 1286640007554 ATP binding site [chemical binding]; other site 1286640007555 Walker B motif; other site 1286640007556 DNA binding loops [nucleotide binding] 1286640007557 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286640007558 MarR family; Region: MarR_2; pfam12802 1286640007559 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1286640007560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640007561 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1286640007562 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640007563 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640007564 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1286640007565 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1286640007566 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1286640007567 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1286640007568 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1286640007569 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1286640007570 dimerization interface [polypeptide binding]; other site 1286640007571 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640007572 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640007573 active site 1286640007574 catalytic tetrad [active] 1286640007575 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1286640007576 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1286640007577 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 1286640007578 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1286640007579 NAD(P) binding site [chemical binding]; other site 1286640007580 homotetramer interface [polypeptide binding]; other site 1286640007581 homodimer interface [polypeptide binding]; other site 1286640007582 active site 1286640007583 acyl carrier protein; Provisional; Region: acpP; PRK00982 1286640007584 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1286640007585 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1286640007586 dimer interface [polypeptide binding]; other site 1286640007587 active site 1286640007588 YceG-like family; Region: YceG; pfam02618 1286640007589 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1286640007590 dimerization interface [polypeptide binding]; other site 1286640007591 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 1286640007592 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1286640007593 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1286640007594 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1286640007595 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1286640007596 catalytic site [active] 1286640007597 G-X2-G-X-G-K; other site 1286640007598 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1286640007599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640007600 S-adenosylmethionine binding site [chemical binding]; other site 1286640007601 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 1286640007602 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1286640007603 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1286640007604 SurA N-terminal domain; Region: SurA_N; pfam09312 1286640007605 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1286640007606 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1286640007607 Predicted permeases [General function prediction only]; Region: COG0795 1286640007608 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1286640007609 Predicted permeases [General function prediction only]; Region: COG0795 1286640007610 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1286640007611 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1286640007612 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1286640007613 interface (dimer of trimers) [polypeptide binding]; other site 1286640007614 Substrate-binding/catalytic site; other site 1286640007615 Zn-binding sites [ion binding]; other site 1286640007616 DNA polymerase III subunit chi; Validated; Region: PRK05728 1286640007617 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1286640007618 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1286640007619 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286640007620 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1286640007621 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1286640007622 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640007623 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640007624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640007625 Coenzyme A binding pocket [chemical binding]; other site 1286640007626 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1286640007627 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286640007628 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286640007629 ABC transporter; Region: ABC_tran_2; pfam12848 1286640007630 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286640007631 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1286640007632 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286640007633 acyl-activating enzyme (AAE) consensus motif; other site 1286640007634 AMP binding site [chemical binding]; other site 1286640007635 active site 1286640007636 CoA binding site [chemical binding]; other site 1286640007637 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1286640007638 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1286640007639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1286640007640 DinB superfamily; Region: DinB_2; pfam12867 1286640007641 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 1286640007642 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640007643 putative C-terminal domain interface [polypeptide binding]; other site 1286640007644 putative GSH binding site (G-site) [chemical binding]; other site 1286640007645 putative dimer interface [polypeptide binding]; other site 1286640007646 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 1286640007647 putative N-terminal domain interface [polypeptide binding]; other site 1286640007648 putative dimer interface [polypeptide binding]; other site 1286640007649 putative substrate binding pocket (H-site) [chemical binding]; other site 1286640007650 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1286640007651 active site 1286640007652 multimer interface [polypeptide binding]; other site 1286640007653 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1286640007654 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1286640007655 CGNR zinc finger; Region: zf-CGNR; pfam11706 1286640007656 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1286640007657 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640007658 TM-ABC transporter signature motif; other site 1286640007659 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1286640007660 MoaE homodimer interface [polypeptide binding]; other site 1286640007661 MoaD interaction [polypeptide binding]; other site 1286640007662 active site residues [active] 1286640007663 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1286640007664 MoaE interaction surface [polypeptide binding]; other site 1286640007665 MoeB interaction surface [polypeptide binding]; other site 1286640007666 thiocarboxylated glycine; other site 1286640007667 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1286640007668 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1286640007669 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1286640007670 GIY-YIG motif/motif A; other site 1286640007671 active site 1286640007672 catalytic site [active] 1286640007673 putative DNA binding site [nucleotide binding]; other site 1286640007674 metal binding site [ion binding]; metal-binding site 1286640007675 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1286640007676 short chain dehydrogenase; Provisional; Region: PRK09134 1286640007677 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 1286640007678 NADP binding site [chemical binding]; other site 1286640007679 substrate binding pocket [chemical binding]; other site 1286640007680 active site 1286640007681 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1286640007682 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640007683 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1286640007684 putative C-terminal domain interface [polypeptide binding]; other site 1286640007685 putative GSH binding site (G-site) [chemical binding]; other site 1286640007686 putative dimer interface [polypeptide binding]; other site 1286640007687 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1286640007688 N-terminal domain interface [polypeptide binding]; other site 1286640007689 dimer interface [polypeptide binding]; other site 1286640007690 putative substrate binding pocket (H-site) [chemical binding]; other site 1286640007691 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1286640007692 B1 nucleotide binding pocket [chemical binding]; other site 1286640007693 B2 nucleotide binding pocket [chemical binding]; other site 1286640007694 CAS motifs; other site 1286640007695 active site 1286640007696 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1286640007697 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1286640007698 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1286640007699 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1286640007700 putative [4Fe-4S] binding site [ion binding]; other site 1286640007701 putative molybdopterin cofactor binding site [chemical binding]; other site 1286640007702 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1286640007703 putative molybdopterin cofactor binding site; other site 1286640007704 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1286640007705 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1286640007706 dimer interface [polypeptide binding]; other site 1286640007707 ADP-ribose binding site [chemical binding]; other site 1286640007708 active site 1286640007709 nudix motif; other site 1286640007710 metal binding site [ion binding]; metal-binding site 1286640007711 Predicted integral membrane protein [Function unknown]; Region: COG0392 1286640007712 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1286640007713 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1286640007714 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 1286640007715 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 1286640007716 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1286640007717 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1286640007718 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1286640007719 active site 1286640007720 substrate binding site [chemical binding]; other site 1286640007721 cosubstrate binding site; other site 1286640007722 catalytic site [active] 1286640007723 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1286640007724 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1286640007725 dimerization interface [polypeptide binding]; other site 1286640007726 putative ATP binding site [chemical binding]; other site 1286640007727 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1286640007728 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1286640007729 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1286640007730 hypothetical protein; Validated; Region: PRK09087 1286640007731 polyphosphate kinase; Provisional; Region: PRK05443 1286640007732 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1286640007733 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1286640007734 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1286640007735 putative domain interface [polypeptide binding]; other site 1286640007736 putative active site [active] 1286640007737 catalytic site [active] 1286640007738 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1286640007739 putative domain interface [polypeptide binding]; other site 1286640007740 putative active site [active] 1286640007741 catalytic site [active] 1286640007742 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1286640007743 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1286640007744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 1286640007745 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640007746 cyclase homology domain; Region: CHD; cd07302 1286640007747 nucleotidyl binding site; other site 1286640007748 metal binding site [ion binding]; metal-binding site 1286640007749 dimer interface [polypeptide binding]; other site 1286640007750 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1286640007751 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1286640007752 catalytic site [active] 1286640007753 putative active site [active] 1286640007754 putative substrate binding site [chemical binding]; other site 1286640007755 HRDC domain; Region: HRDC; pfam00570 1286640007756 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1286640007757 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1286640007758 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1286640007759 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1286640007760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640007761 putative substrate translocation pore; other site 1286640007762 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1286640007763 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1286640007764 dimer interface [polypeptide binding]; other site 1286640007765 anticodon binding site; other site 1286640007766 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1286640007767 homodimer interface [polypeptide binding]; other site 1286640007768 motif 1; other site 1286640007769 active site 1286640007770 motif 2; other site 1286640007771 GAD domain; Region: GAD; pfam02938 1286640007772 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1286640007773 active site 1286640007774 motif 3; other site 1286640007775 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 1286640007776 active site 1286640007777 catalytic residue [active] 1286640007778 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1286640007779 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1286640007780 ring oligomerisation interface [polypeptide binding]; other site 1286640007781 ATP/Mg binding site [chemical binding]; other site 1286640007782 stacking interactions; other site 1286640007783 hinge regions; other site 1286640007784 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1286640007785 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1286640007786 CAP-like domain; other site 1286640007787 active site 1286640007788 primary dimer interface [polypeptide binding]; other site 1286640007789 EamA-like transporter family; Region: EamA; cl17759 1286640007790 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286640007791 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 1286640007792 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1286640007793 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1286640007794 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1286640007795 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1286640007796 dimer interface [polypeptide binding]; other site 1286640007797 allosteric magnesium binding site [ion binding]; other site 1286640007798 active site 1286640007799 aspartate-rich active site metal binding site; other site 1286640007800 Schiff base residues; other site 1286640007801 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286640007802 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1286640007803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1286640007804 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640007805 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286640007806 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286640007807 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1286640007808 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1286640007809 dimer interface [polypeptide binding]; other site 1286640007810 active site 1286640007811 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1286640007812 folate binding site [chemical binding]; other site 1286640007813 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1286640007814 ATP cone domain; Region: ATP-cone; pfam03477 1286640007815 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1286640007816 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1286640007817 catalytic motif [active] 1286640007818 Zn binding site [ion binding]; other site 1286640007819 RibD C-terminal domain; Region: RibD_C; cl17279 1286640007820 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1286640007821 Lumazine binding domain; Region: Lum_binding; pfam00677 1286640007822 Lumazine binding domain; Region: Lum_binding; pfam00677 1286640007823 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286640007824 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 1286640007825 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1286640007826 homopentamer interface [polypeptide binding]; other site 1286640007827 active site 1286640007828 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1286640007829 putative RNA binding site [nucleotide binding]; other site 1286640007830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640007831 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286640007832 putative substrate translocation pore; other site 1286640007833 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 1286640007834 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1286640007835 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1286640007836 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1286640007837 Uncharacterized conserved protein [Function unknown]; Region: COG5452 1286640007838 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1286640007839 putative phosphate acyltransferase; Provisional; Region: PRK05331 1286640007840 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1286640007841 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1286640007842 dimer interface [polypeptide binding]; other site 1286640007843 active site 1286640007844 CoA binding pocket [chemical binding]; other site 1286640007845 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1286640007846 IHF dimer interface [polypeptide binding]; other site 1286640007847 IHF - DNA interface [nucleotide binding]; other site 1286640007848 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1286640007849 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286640007850 DNA binding residues [nucleotide binding] 1286640007851 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1286640007852 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640007853 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1286640007854 O-Antigen ligase; Region: Wzy_C; pfam04932 1286640007855 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1286640007856 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1286640007857 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1286640007858 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640007859 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1286640007860 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1286640007861 SLBB domain; Region: SLBB; pfam10531 1286640007862 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1286640007863 Chain length determinant protein; Region: Wzz; pfam02706 1286640007864 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1286640007865 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1286640007866 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1286640007867 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 1286640007868 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1286640007869 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1286640007870 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1286640007871 trimer interface [polypeptide binding]; other site 1286640007872 active site 1286640007873 substrate binding site [chemical binding]; other site 1286640007874 CoA binding site [chemical binding]; other site 1286640007875 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286640007876 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1286640007877 active site 1286640007878 metal binding site [ion binding]; metal-binding site 1286640007879 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 1286640007880 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1286640007881 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1286640007882 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 1286640007883 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1286640007884 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1286640007885 agmatinase; Region: agmatinase; TIGR01230 1286640007886 oligomer interface [polypeptide binding]; other site 1286640007887 putative active site [active] 1286640007888 Mn binding site [ion binding]; other site 1286640007889 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1286640007890 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1286640007891 23S rRNA interface [nucleotide binding]; other site 1286640007892 L3 interface [polypeptide binding]; other site 1286640007893 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1286640007894 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1286640007895 CoenzymeA binding site [chemical binding]; other site 1286640007896 subunit interaction site [polypeptide binding]; other site 1286640007897 PHB binding site; other site 1286640007898 enoyl-CoA hydratase; Validated; Region: PRK08139 1286640007899 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286640007900 substrate binding site [chemical binding]; other site 1286640007901 oxyanion hole (OAH) forming residues; other site 1286640007902 trimer interface [polypeptide binding]; other site 1286640007903 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1286640007904 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1286640007905 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 1286640007906 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286640007907 homodimer interface [polypeptide binding]; other site 1286640007908 substrate-cofactor binding pocket; other site 1286640007909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640007910 catalytic residue [active] 1286640007911 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1286640007912 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1286640007913 Cytochrome P450; Region: p450; cl12078 1286640007914 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1286640007915 putative catalytic site [active] 1286640007916 putative metal binding site [ion binding]; other site 1286640007917 putative phosphate binding site [ion binding]; other site 1286640007918 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1286640007919 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1286640007920 putative active site [active] 1286640007921 catalytic site [active] 1286640007922 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1286640007923 putative active site [active] 1286640007924 catalytic site [active] 1286640007925 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1286640007926 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1286640007927 oligomer interface [polypeptide binding]; other site 1286640007928 active site residues [active] 1286640007929 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1286640007930 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1286640007931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640007932 Walker A motif; other site 1286640007933 ATP binding site [chemical binding]; other site 1286640007934 Walker B motif; other site 1286640007935 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1286640007936 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1286640007937 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1286640007938 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1286640007939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640007940 Walker A motif; other site 1286640007941 ATP binding site [chemical binding]; other site 1286640007942 Walker B motif; other site 1286640007943 arginine finger; other site 1286640007944 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1286640007945 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1286640007946 IHF dimer interface [polypeptide binding]; other site 1286640007947 IHF - DNA interface [nucleotide binding]; other site 1286640007948 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1286640007949 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286640007950 MarR family; Region: MarR; pfam01047 1286640007951 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1286640007952 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1286640007953 active site 1286640007954 metal binding site [ion binding]; metal-binding site 1286640007955 DNA binding site [nucleotide binding] 1286640007956 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1286640007957 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1286640007958 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1286640007959 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1286640007960 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1286640007961 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1286640007962 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1286640007963 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1286640007964 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1286640007965 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1286640007966 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1286640007967 putative dimer interface [polypeptide binding]; other site 1286640007968 [2Fe-2S] cluster binding site [ion binding]; other site 1286640007969 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 1286640007970 SLBB domain; Region: SLBB; pfam10531 1286640007971 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1286640007972 Uncharacterized conserved protein [Function unknown]; Region: COG3743 1286640007973 NADH dehydrogenase subunit G; Validated; Region: PRK09130 1286640007974 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640007975 catalytic loop [active] 1286640007976 iron binding site [ion binding]; other site 1286640007977 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1286640007978 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 1286640007979 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 1286640007980 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1286640007981 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1286640007982 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1286640007983 4Fe-4S binding domain; Region: Fer4; pfam00037 1286640007984 4Fe-4S binding domain; Region: Fer4; pfam00037 1286640007985 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1286640007986 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1286640007987 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 1286640007988 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1286640007989 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1286640007990 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1286640007991 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286640007992 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1286640007993 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286640007994 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1286640007995 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286640007996 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1286640007997 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1286640007998 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1286640007999 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1286640008000 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286640008001 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1286640008002 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640008003 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1286640008004 dimer interface [polypeptide binding]; other site 1286640008005 substrate binding site [chemical binding]; other site 1286640008006 metal binding site [ion binding]; metal-binding site 1286640008007 Predicted secreted protein [Function unknown]; Region: COG5454 1286640008008 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1286640008009 oligomeric interface; other site 1286640008010 putative active site [active] 1286640008011 homodimer interface [polypeptide binding]; other site 1286640008012 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 1286640008013 prolyl-tRNA synthetase; Provisional; Region: PRK12325 1286640008014 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1286640008015 dimer interface [polypeptide binding]; other site 1286640008016 motif 1; other site 1286640008017 active site 1286640008018 motif 2; other site 1286640008019 motif 3; other site 1286640008020 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1286640008021 anticodon binding site; other site 1286640008022 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1286640008023 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286640008024 FtsX-like permease family; Region: FtsX; pfam02687 1286640008025 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286640008026 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286640008027 Walker A/P-loop; other site 1286640008028 ATP binding site [chemical binding]; other site 1286640008029 Q-loop/lid; other site 1286640008030 ABC transporter signature motif; other site 1286640008031 Walker B; other site 1286640008032 D-loop; other site 1286640008033 H-loop/switch region; other site 1286640008034 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1286640008035 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1286640008036 putative active site [active] 1286640008037 putative PHP Thumb interface [polypeptide binding]; other site 1286640008038 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1286640008039 generic binding surface II; other site 1286640008040 generic binding surface I; other site 1286640008041 hypothetical protein; Provisional; Region: PRK06132 1286640008042 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286640008043 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640008044 DNA polymerase IV; Provisional; Region: PRK02794 1286640008045 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1286640008046 active site 1286640008047 DNA binding site [nucleotide binding] 1286640008048 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 1286640008049 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1286640008050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640008051 active site 1286640008052 phosphorylation site [posttranslational modification] 1286640008053 intermolecular recognition site; other site 1286640008054 dimerization interface [polypeptide binding]; other site 1286640008055 response regulator PleD; Reviewed; Region: pleD; PRK09581 1286640008056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640008057 active site 1286640008058 phosphorylation site [posttranslational modification] 1286640008059 intermolecular recognition site; other site 1286640008060 dimerization interface [polypeptide binding]; other site 1286640008061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640008062 active site 1286640008063 phosphorylation site [posttranslational modification] 1286640008064 intermolecular recognition site; other site 1286640008065 dimerization interface [polypeptide binding]; other site 1286640008066 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640008067 metal binding site [ion binding]; metal-binding site 1286640008068 active site 1286640008069 I-site; other site 1286640008070 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1286640008071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640008072 putative substrate translocation pore; other site 1286640008073 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286640008074 hypothetical protein; Provisional; Region: PRK05978 1286640008075 ribonuclease R; Region: RNase_R; TIGR02063 1286640008076 RNB domain; Region: RNB; pfam00773 1286640008077 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1286640008078 RNA binding site [nucleotide binding]; other site 1286640008079 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1286640008080 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1286640008081 active site 1286640008082 interdomain interaction site; other site 1286640008083 putative metal-binding site [ion binding]; other site 1286640008084 nucleotide binding site [chemical binding]; other site 1286640008085 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1286640008086 domain I; other site 1286640008087 DNA binding groove [nucleotide binding] 1286640008088 phosphate binding site [ion binding]; other site 1286640008089 domain II; other site 1286640008090 domain III; other site 1286640008091 nucleotide binding site [chemical binding]; other site 1286640008092 catalytic site [active] 1286640008093 domain IV; other site 1286640008094 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1286640008095 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1286640008096 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1286640008097 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1286640008098 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1286640008099 DNA protecting protein DprA; Region: dprA; TIGR00732 1286640008100 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1286640008101 dihydroorotase; Validated; Region: PRK09059 1286640008102 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1286640008103 active site 1286640008104 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1286640008105 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1286640008106 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1286640008107 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286640008108 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286640008109 active site 1286640008110 Predicted permeases [General function prediction only]; Region: COG0679 1286640008111 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1286640008112 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1286640008113 metal-dependent hydrolase; Provisional; Region: PRK00685 1286640008114 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1286640008115 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1286640008116 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1286640008117 hypothetical protein; Provisional; Region: PRK13687 1286640008118 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1286640008119 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1286640008120 GatB domain; Region: GatB_Yqey; smart00845 1286640008121 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1286640008122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640008123 Coenzyme A binding pocket [chemical binding]; other site 1286640008124 NADH dehydrogenase; Validated; Region: PRK08183 1286640008125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 1286640008126 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1286640008127 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1286640008128 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286640008129 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1286640008130 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1286640008131 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1286640008132 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1286640008133 carboxyltransferase (CT) interaction site; other site 1286640008134 biotinylation site [posttranslational modification]; other site 1286640008135 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1286640008136 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1286640008137 trimer interface [polypeptide binding]; other site 1286640008138 active site 1286640008139 dimer interface [polypeptide binding]; other site 1286640008140 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1286640008141 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1286640008142 catalytic residues [active] 1286640008143 aspartate aminotransferase; Provisional; Region: PRK05764 1286640008144 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640008145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640008146 homodimer interface [polypeptide binding]; other site 1286640008147 catalytic residue [active] 1286640008148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1286640008149 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640008150 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640008151 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1286640008152 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1286640008153 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 1286640008154 AMIN domain; Region: AMIN; pfam11741 1286640008155 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1286640008156 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1286640008157 active site 1286640008158 metal binding site [ion binding]; metal-binding site 1286640008159 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1286640008160 Transglycosylase; Region: Transgly; pfam00912 1286640008161 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286640008162 peptide chain release factor 2; Provisional; Region: PRK07342 1286640008163 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1286640008164 RF-1 domain; Region: RF-1; pfam00472 1286640008165 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1286640008166 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 1286640008167 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1286640008168 dimer interface [polypeptide binding]; other site 1286640008169 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640008170 ligand binding site [chemical binding]; other site 1286640008171 LysR family transcriptional regulator; Provisional; Region: PRK14997 1286640008172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640008173 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1286640008174 putative effector binding pocket; other site 1286640008175 putative dimerization interface [polypeptide binding]; other site 1286640008176 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1286640008177 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286640008178 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1286640008179 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1286640008180 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1286640008181 elongation factor Tu; Reviewed; Region: PRK00049 1286640008182 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1286640008183 G1 box; other site 1286640008184 GEF interaction site [polypeptide binding]; other site 1286640008185 GTP/Mg2+ binding site [chemical binding]; other site 1286640008186 Switch I region; other site 1286640008187 G2 box; other site 1286640008188 G3 box; other site 1286640008189 Switch II region; other site 1286640008190 G4 box; other site 1286640008191 G5 box; other site 1286640008192 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1286640008193 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1286640008194 Antibiotic Binding Site [chemical binding]; other site 1286640008195 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640008196 extended (e) SDRs; Region: SDR_e; cd08946 1286640008197 NAD(P) binding site [chemical binding]; other site 1286640008198 active site 1286640008199 substrate binding site [chemical binding]; other site 1286640008200 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1286640008201 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1286640008202 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1286640008203 putative homodimer interface [polypeptide binding]; other site 1286640008204 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1286640008205 heterodimer interface [polypeptide binding]; other site 1286640008206 homodimer interface [polypeptide binding]; other site 1286640008207 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1286640008208 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1286640008209 23S rRNA interface [nucleotide binding]; other site 1286640008210 L7/L12 interface [polypeptide binding]; other site 1286640008211 putative thiostrepton binding site; other site 1286640008212 L25 interface [polypeptide binding]; other site 1286640008213 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1286640008214 mRNA/rRNA interface [nucleotide binding]; other site 1286640008215 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1286640008216 23S rRNA interface [nucleotide binding]; other site 1286640008217 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1286640008218 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1286640008219 core dimer interface [polypeptide binding]; other site 1286640008220 peripheral dimer interface [polypeptide binding]; other site 1286640008221 L10 interface [polypeptide binding]; other site 1286640008222 L11 interface [polypeptide binding]; other site 1286640008223 putative EF-Tu interaction site [polypeptide binding]; other site 1286640008224 putative EF-G interaction site [polypeptide binding]; other site 1286640008225 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1286640008226 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1286640008227 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1286640008228 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1286640008229 RPB11 interaction site [polypeptide binding]; other site 1286640008230 RPB12 interaction site [polypeptide binding]; other site 1286640008231 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1286640008232 RPB1 interaction site [polypeptide binding]; other site 1286640008233 RPB11 interaction site [polypeptide binding]; other site 1286640008234 RPB10 interaction site [polypeptide binding]; other site 1286640008235 RPB3 interaction site [polypeptide binding]; other site 1286640008236 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1286640008237 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1286640008238 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1286640008239 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1286640008240 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1286640008241 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1286640008242 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1286640008243 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1286640008244 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 1286640008245 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1286640008246 DNA binding site [nucleotide binding] 1286640008247 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1286640008248 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1286640008249 S17 interaction site [polypeptide binding]; other site 1286640008250 S8 interaction site; other site 1286640008251 16S rRNA interaction site [nucleotide binding]; other site 1286640008252 streptomycin interaction site [chemical binding]; other site 1286640008253 23S rRNA interaction site [nucleotide binding]; other site 1286640008254 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1286640008255 30S ribosomal protein S7; Validated; Region: PRK05302 1286640008256 elongation factor G; Reviewed; Region: PRK00007 1286640008257 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1286640008258 G1 box; other site 1286640008259 putative GEF interaction site [polypeptide binding]; other site 1286640008260 GTP/Mg2+ binding site [chemical binding]; other site 1286640008261 Switch I region; other site 1286640008262 G2 box; other site 1286640008263 G3 box; other site 1286640008264 Switch II region; other site 1286640008265 G4 box; other site 1286640008266 G5 box; other site 1286640008267 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1286640008268 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1286640008269 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1286640008270 elongation factor Tu; Reviewed; Region: PRK00049 1286640008271 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1286640008272 G1 box; other site 1286640008273 GEF interaction site [polypeptide binding]; other site 1286640008274 GTP/Mg2+ binding site [chemical binding]; other site 1286640008275 Switch I region; other site 1286640008276 G2 box; other site 1286640008277 G3 box; other site 1286640008278 Switch II region; other site 1286640008279 G4 box; other site 1286640008280 G5 box; other site 1286640008281 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1286640008282 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1286640008283 Antibiotic Binding Site [chemical binding]; other site 1286640008284 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1286640008285 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1286640008286 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1286640008287 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1286640008288 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1286640008289 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1286640008290 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1286640008291 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1286640008292 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1286640008293 putative translocon binding site; other site 1286640008294 protein-rRNA interface [nucleotide binding]; other site 1286640008295 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1286640008296 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1286640008297 G-X-X-G motif; other site 1286640008298 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1286640008299 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1286640008300 23S rRNA interface [nucleotide binding]; other site 1286640008301 5S rRNA interface [nucleotide binding]; other site 1286640008302 putative antibiotic binding site [chemical binding]; other site 1286640008303 L25 interface [polypeptide binding]; other site 1286640008304 L27 interface [polypeptide binding]; other site 1286640008305 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1286640008306 23S rRNA interface [nucleotide binding]; other site 1286640008307 putative translocon interaction site; other site 1286640008308 signal recognition particle (SRP54) interaction site; other site 1286640008309 L23 interface [polypeptide binding]; other site 1286640008310 trigger factor interaction site; other site 1286640008311 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1286640008312 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1286640008313 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1286640008314 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1286640008315 RNA binding site [nucleotide binding]; other site 1286640008316 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1286640008317 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1286640008318 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1286640008319 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1286640008320 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1286640008321 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1286640008322 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1286640008323 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1286640008324 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1286640008325 23S rRNA interface [nucleotide binding]; other site 1286640008326 L21e interface [polypeptide binding]; other site 1286640008327 5S rRNA interface [nucleotide binding]; other site 1286640008328 L27 interface [polypeptide binding]; other site 1286640008329 L5 interface [polypeptide binding]; other site 1286640008330 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1286640008331 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1286640008332 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1286640008333 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1286640008334 23S rRNA binding site [nucleotide binding]; other site 1286640008335 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1286640008336 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1286640008337 SecY translocase; Region: SecY; pfam00344 1286640008338 adenylate kinase; Reviewed; Region: adk; PRK00279 1286640008339 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1286640008340 AMP-binding site [chemical binding]; other site 1286640008341 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1286640008342 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1286640008343 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1286640008344 30S ribosomal protein S11; Validated; Region: PRK05309 1286640008345 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1286640008346 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1286640008347 alphaNTD homodimer interface [polypeptide binding]; other site 1286640008348 alphaNTD - beta interaction site [polypeptide binding]; other site 1286640008349 alphaNTD - beta' interaction site [polypeptide binding]; other site 1286640008350 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1286640008351 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1286640008352 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1286640008353 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1286640008354 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1286640008355 Moco binding site; other site 1286640008356 metal coordination site [ion binding]; other site 1286640008357 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1286640008358 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1286640008359 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286640008360 protein binding site [polypeptide binding]; other site 1286640008361 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286640008362 protein binding site [polypeptide binding]; other site 1286640008363 recombination factor protein RarA; Reviewed; Region: PRK13342 1286640008364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640008365 Walker A motif; other site 1286640008366 ATP binding site [chemical binding]; other site 1286640008367 Walker B motif; other site 1286640008368 arginine finger; other site 1286640008369 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1286640008370 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1286640008371 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 1286640008372 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1286640008373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640008374 motif II; other site 1286640008375 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1286640008376 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1286640008377 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1286640008378 active site 1286640008379 camphor resistance protein CrcB; Provisional; Region: PRK14195 1286640008380 S-formylglutathione hydrolase; Region: PLN02442 1286640008381 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1286640008382 Predicted membrane protein [Function unknown]; Region: COG4291 1286640008383 hypothetical protein; Validated; Region: PRK00124 1286640008384 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1286640008385 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1286640008386 substrate binding site [chemical binding]; other site 1286640008387 catalytic Zn binding site [ion binding]; other site 1286640008388 NAD binding site [chemical binding]; other site 1286640008389 structural Zn binding site [ion binding]; other site 1286640008390 dimer interface [polypeptide binding]; other site 1286640008391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640008392 non-specific DNA binding site [nucleotide binding]; other site 1286640008393 salt bridge; other site 1286640008394 sequence-specific DNA binding site [nucleotide binding]; other site 1286640008395 lipoate-protein ligase B; Provisional; Region: PRK14341 1286640008396 PrkA family serine protein kinase; Provisional; Region: PRK15455 1286640008397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1286640008398 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1286640008399 Uncharacterized conserved protein [Function unknown]; Region: COG2718 1286640008400 SpoVR family protein; Provisional; Region: PRK11767 1286640008401 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1286640008402 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1286640008403 active site 1286640008404 catalytic residues [active] 1286640008405 metal binding site [ion binding]; metal-binding site 1286640008406 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1286640008407 MgtE intracellular N domain; Region: MgtE_N; smart00924 1286640008408 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1286640008409 Divalent cation transporter; Region: MgtE; cl00786 1286640008410 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1286640008411 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1286640008412 DNA binding residues [nucleotide binding] 1286640008413 putative dimer interface [polypeptide binding]; other site 1286640008414 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1286640008415 Predicted membrane protein [Function unknown]; Region: COG3503 1286640008416 Predicted membrane protein [Function unknown]; Region: COG3821 1286640008417 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1286640008418 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1286640008419 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1286640008420 Uncharacterized conserved protein [Function unknown]; Region: COG5458 1286640008421 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286640008422 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1286640008423 Sporulation related domain; Region: SPOR; pfam05036 1286640008424 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 1286640008425 PilZ domain; Region: PilZ; pfam07238 1286640008426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 1286640008427 PAS domain; Region: PAS_5; pfam07310 1286640008428 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1286640008429 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1286640008430 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1286640008431 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1286640008432 nucleophile elbow; other site 1286640008433 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1286640008434 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1286640008435 GTP cyclohydrolase I; Provisional; Region: PLN03044 1286640008436 active site 1286640008437 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1286640008438 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1286640008439 trimerization site [polypeptide binding]; other site 1286640008440 active site 1286640008441 hypothetical protein; Validated; Region: PRK00041 1286640008442 Uncharacterized conserved protein [Function unknown]; Region: COG5502 1286640008443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1286640008444 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1286640008445 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1286640008446 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1286640008447 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1286640008448 active site 1286640008449 dimer interface [polypeptide binding]; other site 1286640008450 motif 1; other site 1286640008451 motif 2; other site 1286640008452 motif 3; other site 1286640008453 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1286640008454 anticodon binding site; other site 1286640008455 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1286640008456 putative FMN binding site [chemical binding]; other site 1286640008457 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1286640008458 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1286640008459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 1286640008460 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1286640008461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640008462 Coenzyme A binding pocket [chemical binding]; other site 1286640008463 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1286640008464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640008465 Mg2+ binding site [ion binding]; other site 1286640008466 G-X-G motif; other site 1286640008467 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1286640008468 anchoring element; other site 1286640008469 dimer interface [polypeptide binding]; other site 1286640008470 ATP binding site [chemical binding]; other site 1286640008471 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1286640008472 active site 1286640008473 metal binding site [ion binding]; metal-binding site 1286640008474 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1286640008475 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1286640008476 FAD binding domain; Region: FAD_binding_4; pfam01565 1286640008477 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286640008478 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1286640008479 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1286640008480 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1286640008481 triosephosphate isomerase; Provisional; Region: PRK14565 1286640008482 substrate binding site [chemical binding]; other site 1286640008483 dimer interface [polypeptide binding]; other site 1286640008484 catalytic triad [active] 1286640008485 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1286640008486 CTP synthetase; Validated; Region: pyrG; PRK05380 1286640008487 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1286640008488 Catalytic site [active] 1286640008489 active site 1286640008490 UTP binding site [chemical binding]; other site 1286640008491 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1286640008492 active site 1286640008493 putative oxyanion hole; other site 1286640008494 catalytic triad [active] 1286640008495 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1286640008496 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1286640008497 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1286640008498 enolase; Provisional; Region: eno; PRK00077 1286640008499 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1286640008500 dimer interface [polypeptide binding]; other site 1286640008501 metal binding site [ion binding]; metal-binding site 1286640008502 substrate binding pocket [chemical binding]; other site 1286640008503 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1286640008504 Septum formation initiator; Region: DivIC; pfam04977 1286640008505 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1286640008506 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1286640008507 tetramer interface [polypeptide binding]; other site 1286640008508 TPP-binding site [chemical binding]; other site 1286640008509 heterodimer interface [polypeptide binding]; other site 1286640008510 phosphorylation loop region [posttranslational modification] 1286640008511 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 1286640008512 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1286640008513 E3 interaction surface; other site 1286640008514 lipoyl attachment site [posttranslational modification]; other site 1286640008515 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1286640008516 alpha subunit interface [polypeptide binding]; other site 1286640008517 TPP binding site [chemical binding]; other site 1286640008518 heterodimer interface [polypeptide binding]; other site 1286640008519 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286640008520 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1286640008521 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 1286640008522 E3 interaction surface; other site 1286640008523 lipoyl attachment site [posttranslational modification]; other site 1286640008524 e3 binding domain; Region: E3_binding; pfam02817 1286640008525 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1286640008526 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 1286640008527 active site 1286640008528 catalytic triad [active] 1286640008529 oxyanion hole [active] 1286640008530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640008531 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286640008532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286640008533 Coenzyme A binding pocket [chemical binding]; other site 1286640008534 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1286640008535 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1286640008536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640008537 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286640008538 Predicted membrane protein [Function unknown]; Region: COG2261 1286640008539 lipoyl synthase; Provisional; Region: PRK05481 1286640008540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286640008541 FeS/SAM binding site; other site 1286640008542 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1286640008543 putative coenzyme Q binding site [chemical binding]; other site 1286640008544 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1286640008545 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 1286640008546 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1286640008547 substrate binding site; other site 1286640008548 dimer interface; other site 1286640008549 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1286640008550 homotrimer interaction site [polypeptide binding]; other site 1286640008551 zinc binding site [ion binding]; other site 1286640008552 CDP-binding sites; other site 1286640008553 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1286640008554 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 1286640008555 FMN binding site [chemical binding]; other site 1286640008556 active site 1286640008557 catalytic residues [active] 1286640008558 substrate binding site [chemical binding]; other site 1286640008559 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1286640008560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640008561 dimer interface [polypeptide binding]; other site 1286640008562 phosphorylation site [posttranslational modification] 1286640008563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640008564 ATP binding site [chemical binding]; other site 1286640008565 Mg2+ binding site [ion binding]; other site 1286640008566 G-X-G motif; other site 1286640008567 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1286640008568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640008569 active site 1286640008570 phosphorylation site [posttranslational modification] 1286640008571 intermolecular recognition site; other site 1286640008572 dimerization interface [polypeptide binding]; other site 1286640008573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640008574 Walker A motif; other site 1286640008575 ATP binding site [chemical binding]; other site 1286640008576 Walker B motif; other site 1286640008577 arginine finger; other site 1286640008578 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1286640008579 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 1286640008580 HAMP domain; Region: HAMP; pfam00672 1286640008581 dimerization interface [polypeptide binding]; other site 1286640008582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640008583 dimer interface [polypeptide binding]; other site 1286640008584 phosphorylation site [posttranslational modification] 1286640008585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640008586 ATP binding site [chemical binding]; other site 1286640008587 Mg2+ binding site [ion binding]; other site 1286640008588 G-X-G motif; other site 1286640008589 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1286640008590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640008591 active site 1286640008592 phosphorylation site [posttranslational modification] 1286640008593 intermolecular recognition site; other site 1286640008594 dimerization interface [polypeptide binding]; other site 1286640008595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640008596 Walker A motif; other site 1286640008597 ATP binding site [chemical binding]; other site 1286640008598 Walker B motif; other site 1286640008599 arginine finger; other site 1286640008600 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286640008601 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1286640008602 TrkA-N domain; Region: TrkA_N; pfam02254 1286640008603 TrkA-C domain; Region: TrkA_C; pfam02080 1286640008604 TrkA-N domain; Region: TrkA_N; pfam02254 1286640008605 TrkA-C domain; Region: TrkA_C; pfam02080 1286640008606 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1286640008607 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1286640008608 homodimer interface [polypeptide binding]; other site 1286640008609 substrate-cofactor binding pocket; other site 1286640008610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640008611 catalytic residue [active] 1286640008612 bacterial Hfq-like; Region: Hfq; cd01716 1286640008613 hexamer interface [polypeptide binding]; other site 1286640008614 Sm1 motif; other site 1286640008615 RNA binding site [nucleotide binding]; other site 1286640008616 Sm2 motif; other site 1286640008617 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1286640008618 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1286640008619 HflX GTPase family; Region: HflX; cd01878 1286640008620 G1 box; other site 1286640008621 GTP/Mg2+ binding site [chemical binding]; other site 1286640008622 Switch I region; other site 1286640008623 G2 box; other site 1286640008624 G3 box; other site 1286640008625 Switch II region; other site 1286640008626 G4 box; other site 1286640008627 G5 box; other site 1286640008628 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640008629 Winged helix-turn helix; Region: HTH_29; pfam13551 1286640008630 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640008631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1286640008632 Integrase core domain; Region: rve; pfam00665 1286640008633 Integrase core domain; Region: rve_3; pfam13683 1286640008634 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1286640008635 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1286640008636 homodimer interface [polypeptide binding]; other site 1286640008637 metal binding site [ion binding]; metal-binding site 1286640008638 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1286640008639 homodimer interface [polypeptide binding]; other site 1286640008640 active site 1286640008641 putative chemical substrate binding site [chemical binding]; other site 1286640008642 metal binding site [ion binding]; metal-binding site 1286640008643 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1286640008644 nucleoside/Zn binding site; other site 1286640008645 dimer interface [polypeptide binding]; other site 1286640008646 catalytic motif [active] 1286640008647 siroheme synthase; Provisional; Region: cysG; PRK10637 1286640008648 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1286640008649 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1286640008650 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1286640008651 active site 1286640008652 SAM binding site [chemical binding]; other site 1286640008653 homodimer interface [polypeptide binding]; other site 1286640008654 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 1286640008655 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1286640008656 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1286640008657 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1286640008658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 1286640008659 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1286640008660 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1286640008661 FAD binding pocket [chemical binding]; other site 1286640008662 FAD binding motif [chemical binding]; other site 1286640008663 phosphate binding motif [ion binding]; other site 1286640008664 beta-alpha-beta structure motif; other site 1286640008665 NAD binding pocket [chemical binding]; other site 1286640008666 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1286640008667 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286640008668 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286640008669 Walker A/P-loop; other site 1286640008670 ATP binding site [chemical binding]; other site 1286640008671 Q-loop/lid; other site 1286640008672 ABC transporter signature motif; other site 1286640008673 Walker B; other site 1286640008674 D-loop; other site 1286640008675 H-loop/switch region; other site 1286640008676 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640008677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640008678 dimer interface [polypeptide binding]; other site 1286640008679 conserved gate region; other site 1286640008680 putative PBP binding loops; other site 1286640008681 ABC-ATPase subunit interface; other site 1286640008682 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1286640008683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286640008684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640008685 dimer interface [polypeptide binding]; other site 1286640008686 conserved gate region; other site 1286640008687 putative PBP binding loops; other site 1286640008688 ABC-ATPase subunit interface; other site 1286640008689 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1286640008690 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640008691 substrate binding pocket [chemical binding]; other site 1286640008692 membrane-bound complex binding site; other site 1286640008693 hinge residues; other site 1286640008694 cystathionine beta-lyase; Provisional; Region: PRK05967 1286640008695 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286640008696 homodimer interface [polypeptide binding]; other site 1286640008697 substrate-cofactor binding pocket; other site 1286640008698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640008699 catalytic residue [active] 1286640008700 salicylate hydroxylase; Provisional; Region: PRK08163 1286640008701 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1286640008702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 1286640008703 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286640008704 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286640008705 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1286640008706 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 1286640008707 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1286640008708 trimer interface [polypeptide binding]; other site 1286640008709 active site 1286640008710 substrate binding site [chemical binding]; other site 1286640008711 CoA binding site [chemical binding]; other site 1286640008712 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 1286640008713 Phasin protein; Region: Phasin_2; pfam09361 1286640008714 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1286640008715 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1286640008716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640008717 Walker A motif; other site 1286640008718 ATP binding site [chemical binding]; other site 1286640008719 Walker B motif; other site 1286640008720 arginine finger; other site 1286640008721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640008722 Walker A motif; other site 1286640008723 ATP binding site [chemical binding]; other site 1286640008724 Walker B motif; other site 1286640008725 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1286640008726 AzlC protein; Region: AzlC; pfam03591 1286640008727 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1286640008728 HIT family signature motif; other site 1286640008729 catalytic residue [active] 1286640008730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 1286640008731 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1286640008732 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 1286640008733 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1286640008734 putative active site [active] 1286640008735 catalytic site [active] 1286640008736 putative metal binding site [ion binding]; other site 1286640008737 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1286640008738 homotrimer interaction site [polypeptide binding]; other site 1286640008739 putative active site [active] 1286640008740 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 1286640008741 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1286640008742 rRNA interaction site [nucleotide binding]; other site 1286640008743 S8 interaction site; other site 1286640008744 putative laminin-1 binding site; other site 1286640008745 elongation factor Ts; Provisional; Region: tsf; PRK09377 1286640008746 UBA/TS-N domain; Region: UBA; pfam00627 1286640008747 Elongation factor TS; Region: EF_TS; pfam00889 1286640008748 Elongation factor TS; Region: EF_TS; pfam00889 1286640008749 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1286640008750 putative nucleotide binding site [chemical binding]; other site 1286640008751 uridine monophosphate binding site [chemical binding]; other site 1286640008752 homohexameric interface [polypeptide binding]; other site 1286640008753 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1286640008754 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1286640008755 hinge region; other site 1286640008756 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 1286640008757 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1286640008758 catalytic residue [active] 1286640008759 putative FPP diphosphate binding site; other site 1286640008760 putative FPP binding hydrophobic cleft; other site 1286640008761 dimer interface [polypeptide binding]; other site 1286640008762 putative IPP diphosphate binding site; other site 1286640008763 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1286640008764 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1286640008765 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1286640008766 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1286640008767 active site 1286640008768 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1286640008769 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1286640008770 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1286640008771 putative substrate binding region [chemical binding]; other site 1286640008772 putative substrate binding region [chemical binding]; other site 1286640008773 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 1286640008774 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286640008775 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286640008776 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286640008777 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286640008778 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286640008779 Surface antigen; Region: Bac_surface_Ag; pfam01103 1286640008780 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1286640008781 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1286640008782 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1286640008783 trimer interface [polypeptide binding]; other site 1286640008784 active site 1286640008785 UDP-GlcNAc binding site [chemical binding]; other site 1286640008786 lipid binding site [chemical binding]; lipid-binding site 1286640008787 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1286640008788 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 1286640008789 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1286640008790 active site 1286640008791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 1286640008792 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 1286640008793 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1286640008794 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 1286640008795 GIY-YIG motif/motif A; other site 1286640008796 putative active site [active] 1286640008797 putative metal binding site [ion binding]; other site 1286640008798 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1286640008799 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1286640008800 dimer interface [polypeptide binding]; other site 1286640008801 active site 1286640008802 citrylCoA binding site [chemical binding]; other site 1286640008803 NADH binding [chemical binding]; other site 1286640008804 cationic pore residues; other site 1286640008805 oxalacetate/citrate binding site [chemical binding]; other site 1286640008806 coenzyme A binding site [chemical binding]; other site 1286640008807 catalytic triad [active] 1286640008808 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1286640008809 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1286640008810 Competence protein; Region: Competence; pfam03772 1286640008811 tonB-system energizer ExbB; Region: exbB; TIGR02797 1286640008812 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1286640008813 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1286640008814 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1286640008815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1286640008816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640008817 S-adenosylmethionine binding site [chemical binding]; other site 1286640008818 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1286640008819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 1286640008820 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1286640008821 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1286640008822 HIGH motif; other site 1286640008823 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1286640008824 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1286640008825 active site 1286640008826 KMSKS motif; other site 1286640008827 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1286640008828 tRNA binding surface [nucleotide binding]; other site 1286640008829 anticodon binding site; other site 1286640008830 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1286640008831 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 1286640008832 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1286640008833 Sel1-like repeats; Region: SEL1; smart00671 1286640008834 Sel1-like repeats; Region: SEL1; smart00671 1286640008835 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1286640008836 putative catalytic site [active] 1286640008837 putative phosphate binding site [ion binding]; other site 1286640008838 active site 1286640008839 metal binding site A [ion binding]; metal-binding site 1286640008840 DNA binding site [nucleotide binding] 1286640008841 putative AP binding site [nucleotide binding]; other site 1286640008842 putative metal binding site B [ion binding]; other site 1286640008843 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1286640008844 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1286640008845 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 1286640008846 putative active site [active] 1286640008847 catalytic site [active] 1286640008848 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 1286640008849 putative active site [active] 1286640008850 catalytic site [active] 1286640008851 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1286640008852 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1286640008853 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286640008854 Zn2+ binding site [ion binding]; other site 1286640008855 Mg2+ binding site [ion binding]; other site 1286640008856 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1286640008857 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1286640008858 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1286640008859 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1286640008860 active site 1286640008861 HIGH motif; other site 1286640008862 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1286640008863 KMSK motif region; other site 1286640008864 tRNA binding surface [nucleotide binding]; other site 1286640008865 DALR anticodon binding domain; Region: DALR_1; smart00836 1286640008866 anticodon binding site; other site 1286640008867 Sporulation related domain; Region: SPOR; pfam05036 1286640008868 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1286640008869 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1286640008870 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1286640008871 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1286640008872 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286640008873 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1286640008874 Walker A/P-loop; other site 1286640008875 ATP binding site [chemical binding]; other site 1286640008876 Q-loop/lid; other site 1286640008877 ABC transporter signature motif; other site 1286640008878 Walker B; other site 1286640008879 D-loop; other site 1286640008880 H-loop/switch region; other site 1286640008881 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 1286640008882 sec-independent translocase; Provisional; Region: PRK00708 1286640008883 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1286640008884 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1286640008885 seryl-tRNA synthetase; Provisional; Region: PRK05431 1286640008886 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1286640008887 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1286640008888 dimer interface [polypeptide binding]; other site 1286640008889 active site 1286640008890 motif 1; other site 1286640008891 motif 2; other site 1286640008892 motif 3; other site 1286640008893 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1286640008894 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1286640008895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640008896 S-adenosylmethionine binding site [chemical binding]; other site 1286640008897 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1286640008898 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286640008899 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286640008900 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286640008901 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286640008902 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1286640008903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640008904 Walker A motif; other site 1286640008905 ATP binding site [chemical binding]; other site 1286640008906 Walker B motif; other site 1286640008907 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1286640008908 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 1286640008909 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1286640008910 Protein export membrane protein; Region: SecD_SecF; cl14618 1286640008911 Protein export membrane protein; Region: SecD_SecF; pfam02355 1286640008912 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 1286640008913 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1286640008914 substrate binding pocket [chemical binding]; other site 1286640008915 aspartate-rich region 1; other site 1286640008916 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1286640008917 Glucose inhibited division protein A; Region: GIDA; pfam01134 1286640008918 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1286640008919 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1286640008920 trigger factor; Provisional; Region: tig; PRK01490 1286640008921 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1286640008922 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1286640008923 glycine dehydrogenase; Provisional; Region: PRK05367 1286640008924 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1286640008925 tetramer interface [polypeptide binding]; other site 1286640008926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640008927 catalytic residue [active] 1286640008928 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1286640008929 tetramer interface [polypeptide binding]; other site 1286640008930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640008931 catalytic residue [active] 1286640008932 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1286640008933 lipoyl attachment site [posttranslational modification]; other site 1286640008934 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1286640008935 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1286640008936 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1286640008937 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 1286640008938 CRISPR-associated protein, Csx11 family; Region: cas_csx11; TIGR02682 1286640008939 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1286640008940 MULE transposase domain; Region: MULE; pfam10551 1286640008941 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1286640008942 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640008943 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1286640008944 dimer interface [polypeptide binding]; other site 1286640008945 N-terminal domain interface [polypeptide binding]; other site 1286640008946 substrate binding pocket (H-site) [chemical binding]; other site 1286640008947 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 1286640008948 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1286640008949 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1286640008950 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1286640008951 active site 1286640008952 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1286640008953 TSCPD domain; Region: TSCPD; pfam12637 1286640008954 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1286640008955 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1286640008956 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1286640008957 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1286640008958 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1286640008959 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1286640008960 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1286640008961 dimer interface [polypeptide binding]; other site 1286640008962 ssDNA binding site [nucleotide binding]; other site 1286640008963 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286640008964 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1286640008965 DNA gyrase subunit A; Validated; Region: PRK05560 1286640008966 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1286640008967 CAP-like domain; other site 1286640008968 active site 1286640008969 primary dimer interface [polypeptide binding]; other site 1286640008970 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286640008971 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286640008972 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286640008973 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286640008974 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286640008975 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1286640008976 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286640008977 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286640008978 catalytic residue [active] 1286640008979 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1286640008980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640008981 Coenzyme A binding pocket [chemical binding]; other site 1286640008982 Streptomycin 6-kinase [Defense mechanisms]; Region: StrB; COG3570 1286640008983 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1286640008984 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1286640008985 FMN binding site [chemical binding]; other site 1286640008986 active site 1286640008987 substrate binding site [chemical binding]; other site 1286640008988 catalytic residue [active] 1286640008989 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640008990 dimerization interface [polypeptide binding]; other site 1286640008991 putative DNA binding site [nucleotide binding]; other site 1286640008992 putative Zn2+ binding site [ion binding]; other site 1286640008993 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640008994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640008995 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640008996 putative effector binding pocket; other site 1286640008997 dimerization interface [polypeptide binding]; other site 1286640008998 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1286640008999 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286640009000 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640009001 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640009002 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640009003 putative DNA binding site [nucleotide binding]; other site 1286640009004 putative Zn2+ binding site [ion binding]; other site 1286640009005 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640009006 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1286640009007 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286640009008 putative metal binding site; other site 1286640009009 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640009010 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1286640009011 putative ADP-binding pocket [chemical binding]; other site 1286640009012 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640009013 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1286640009014 putative ADP-binding pocket [chemical binding]; other site 1286640009015 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1286640009016 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640009017 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1286640009018 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1286640009019 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1286640009020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640009021 putative substrate translocation pore; other site 1286640009022 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1286640009023 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286640009024 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1286640009025 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1286640009026 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286640009027 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1286640009028 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1286640009029 IMP binding site; other site 1286640009030 dimer interface [polypeptide binding]; other site 1286640009031 partial ornithine binding site; other site 1286640009032 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286640009033 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 1286640009034 putative NAD(P) binding site [chemical binding]; other site 1286640009035 catalytic Zn binding site [ion binding]; other site 1286640009036 Predicted metalloprotease [General function prediction only]; Region: COG2321 1286640009037 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1286640009038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640009039 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286640009040 putative substrate translocation pore; other site 1286640009041 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1286640009042 putative efflux protein, MATE family; Region: matE; TIGR00797 1286640009043 cation binding site [ion binding]; other site 1286640009044 Protein of unknown function DUF86; Region: DUF86; cl01031 1286640009045 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1286640009046 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1286640009047 active site 1286640009048 (T/H)XGH motif; other site 1286640009049 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1286640009050 active site 1286640009051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1286640009052 active site 1286640009053 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1286640009054 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1286640009055 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1286640009056 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1286640009057 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286640009058 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640009059 substrate binding pocket [chemical binding]; other site 1286640009060 membrane-bound complex binding site; other site 1286640009061 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1286640009062 classical (c) SDRs; Region: SDR_c; cd05233 1286640009063 NAD(P) binding site [chemical binding]; other site 1286640009064 active site 1286640009065 SEC-C motif; Region: SEC-C; pfam02810 1286640009066 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1286640009067 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1286640009068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1286640009069 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286640009070 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640009071 classical (c) SDRs; Region: SDR_c; cd05233 1286640009072 NAD(P) binding site [chemical binding]; other site 1286640009073 active site 1286640009074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640009075 putative substrate translocation pore; other site 1286640009076 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1286640009077 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640009078 DNA binding site [nucleotide binding] 1286640009079 Predicted integral membrane protein [Function unknown]; Region: COG5616 1286640009080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640009081 TPR motif; other site 1286640009082 binding surface 1286640009083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640009084 TPR motif; other site 1286640009085 binding surface 1286640009086 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1286640009087 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1286640009088 Winged helix-turn helix; Region: HTH_29; pfam13551 1286640009089 DNA-binding interface [nucleotide binding]; DNA binding site 1286640009090 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640009091 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1286640009092 putative hydrolase; Provisional; Region: PRK02113 1286640009093 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1286640009094 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1286640009095 active site 1286640009096 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1286640009097 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1286640009098 active site 1286640009099 HIGH motif; other site 1286640009100 KMSKS motif; other site 1286640009101 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1286640009102 tRNA binding surface [nucleotide binding]; other site 1286640009103 anticodon binding site; other site 1286640009104 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538 1286640009105 metal binding site [ion binding]; metal-binding site 1286640009106 DNA polymerase III subunit delta'; Validated; Region: PRK09112 1286640009107 AAA ATPase domain; Region: AAA_16; pfam13191 1286640009108 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1286640009109 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286640009110 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1286640009111 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 1286640009112 TMP-binding site; other site 1286640009113 ATP-binding site [chemical binding]; other site 1286640009114 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1286640009115 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286640009116 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1286640009117 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1286640009118 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1286640009119 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1286640009120 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1286640009121 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1286640009122 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1286640009123 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1286640009124 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1286640009125 LexA repressor; Validated; Region: PRK00215 1286640009126 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1286640009127 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1286640009128 Catalytic site [active] 1286640009129 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1286640009130 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1286640009131 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1286640009132 putative active site [active] 1286640009133 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1286640009134 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1286640009135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640009136 short chain dehydrogenase; Provisional; Region: PRK06101 1286640009137 NAD(P) binding site [chemical binding]; other site 1286640009138 active site 1286640009139 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1286640009140 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1286640009141 dimer interface [polypeptide binding]; other site 1286640009142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640009143 catalytic residue [active] 1286640009144 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1286640009145 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1286640009146 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1286640009147 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1286640009148 active site residue [active] 1286640009149 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1286640009150 active site residue [active] 1286640009151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286640009152 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 1286640009153 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1286640009154 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1286640009155 hexamer interface [polypeptide binding]; other site 1286640009156 ligand binding site [chemical binding]; other site 1286640009157 putative active site [active] 1286640009158 NAD(P) binding site [chemical binding]; other site 1286640009159 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640009160 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640009161 putative DNA binding site [nucleotide binding]; other site 1286640009162 putative Zn2+ binding site [ion binding]; other site 1286640009163 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640009164 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1286640009165 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1286640009166 active site 1286640009167 metal binding site [ion binding]; metal-binding site 1286640009168 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1286640009169 Uncharacterized conserved protein [Function unknown]; Region: COG5453 1286640009170 threonine dehydratase; Validated; Region: PRK08639 1286640009171 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1286640009172 tetramer interface [polypeptide binding]; other site 1286640009173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640009174 catalytic residue [active] 1286640009175 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1286640009176 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1286640009177 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1286640009178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1286640009179 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1286640009180 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286640009181 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1286640009182 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1286640009183 putative MPT binding site; other site 1286640009184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286640009185 active site 1286640009186 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1286640009187 putative carbohydrate kinase; Provisional; Region: PRK10565 1286640009188 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1286640009189 putative substrate binding site [chemical binding]; other site 1286640009190 putative ATP binding site [chemical binding]; other site 1286640009191 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1286640009192 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1286640009193 glutamine synthetase; Provisional; Region: glnA; PRK09469 1286640009194 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1286640009195 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1286640009196 Uncharacterized conserved protein [Function unknown]; Region: COG3785 1286640009197 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 1286640009198 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286640009199 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1286640009200 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1286640009201 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1286640009202 catalytic residues [active] 1286640009203 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1286640009204 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640009205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640009206 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1286640009207 Sulfatase; Region: Sulfatase; pfam00884 1286640009208 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1286640009209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 1286640009210 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1286640009211 putative catalytic site [active] 1286640009212 putative phosphate binding site [ion binding]; other site 1286640009213 active site 1286640009214 metal binding site A [ion binding]; metal-binding site 1286640009215 DNA binding site [nucleotide binding] 1286640009216 putative AP binding site [nucleotide binding]; other site 1286640009217 putative metal binding site B [ion binding]; other site 1286640009218 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1286640009219 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1286640009220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286640009221 ATP binding site [chemical binding]; other site 1286640009222 putative Mg++ binding site [ion binding]; other site 1286640009223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286640009224 nucleotide binding region [chemical binding]; other site 1286640009225 ATP-binding site [chemical binding]; other site 1286640009226 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1286640009227 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1286640009228 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1286640009229 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1286640009230 generic binding surface II; other site 1286640009231 ssDNA binding site; other site 1286640009232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286640009233 ATP binding site [chemical binding]; other site 1286640009234 putative Mg++ binding site [ion binding]; other site 1286640009235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286640009236 nucleotide binding region [chemical binding]; other site 1286640009237 ATP-binding site [chemical binding]; other site 1286640009238 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1286640009239 putative acetyltransferase; Provisional; Region: PRK03624 1286640009240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640009241 Coenzyme A binding pocket [chemical binding]; other site 1286640009242 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1286640009243 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1286640009244 glutaminase active site [active] 1286640009245 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1286640009246 dimer interface [polypeptide binding]; other site 1286640009247 active site 1286640009248 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1286640009249 dimer interface [polypeptide binding]; other site 1286640009250 active site 1286640009251 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 1286640009252 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1286640009253 Substrate binding site; other site 1286640009254 Mg++ binding site; other site 1286640009255 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1286640009256 active site 1286640009257 substrate binding site [chemical binding]; other site 1286640009258 CoA binding site [chemical binding]; other site 1286640009259 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1286640009260 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1286640009261 PhoU domain; Region: PhoU; pfam01895 1286640009262 PhoU domain; Region: PhoU; pfam01895 1286640009263 SurA N-terminal domain; Region: SurA_N_3; cl07813 1286640009264 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1286640009265 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1286640009266 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1286640009267 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1286640009268 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1286640009269 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1286640009270 active site 1286640009271 ribulose/triose binding site [chemical binding]; other site 1286640009272 phosphate binding site [ion binding]; other site 1286640009273 substrate (anthranilate) binding pocket [chemical binding]; other site 1286640009274 product (indole) binding pocket [chemical binding]; other site 1286640009275 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1286640009276 trimer interface [polypeptide binding]; other site 1286640009277 dimer interface [polypeptide binding]; other site 1286640009278 putative active site [active] 1286640009279 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1286640009280 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1286640009281 dimer interface [polypeptide binding]; other site 1286640009282 putative functional site; other site 1286640009283 putative MPT binding site; other site 1286640009284 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1286640009285 Domain of unknown function DUF21; Region: DUF21; pfam01595 1286640009286 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1286640009287 Transporter associated domain; Region: CorC_HlyC; smart01091 1286640009288 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640009289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640009290 DNA-binding site [nucleotide binding]; DNA binding site 1286640009291 FCD domain; Region: FCD; pfam07729 1286640009292 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1286640009293 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1286640009294 putative ligand binding site [chemical binding]; other site 1286640009295 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640009296 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1286640009297 TM-ABC transporter signature motif; other site 1286640009298 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640009299 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1286640009300 TM-ABC transporter signature motif; other site 1286640009301 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1286640009302 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640009303 Walker A/P-loop; other site 1286640009304 ATP binding site [chemical binding]; other site 1286640009305 Q-loop/lid; other site 1286640009306 ABC transporter signature motif; other site 1286640009307 Walker B; other site 1286640009308 D-loop; other site 1286640009309 H-loop/switch region; other site 1286640009310 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640009311 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1286640009312 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1286640009313 NADP binding site [chemical binding]; other site 1286640009314 dimer interface [polypeptide binding]; other site 1286640009315 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1286640009316 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1286640009317 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 1286640009318 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1286640009319 Predicted permeases [General function prediction only]; Region: COG0679 1286640009320 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1286640009321 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1286640009322 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1286640009323 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1286640009324 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1286640009325 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1286640009326 conserved cys residue [active] 1286640009327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640009328 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1286640009329 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cl00720 1286640009330 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640009331 classical (c) SDRs; Region: SDR_c; cd05233 1286640009332 NAD(P) binding site [chemical binding]; other site 1286640009333 active site 1286640009334 acyl-CoA synthetase; Validated; Region: PRK07470 1286640009335 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286640009336 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1286640009337 acyl-activating enzyme (AAE) consensus motif; other site 1286640009338 acyl-activating enzyme (AAE) consensus motif; other site 1286640009339 putative AMP binding site [chemical binding]; other site 1286640009340 putative active site [active] 1286640009341 putative CoA binding site [chemical binding]; other site 1286640009342 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 1286640009343 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1286640009344 active site 1286640009345 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286640009346 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1286640009347 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640009348 classical (c) SDRs; Region: SDR_c; cd05233 1286640009349 NAD(P) binding site [chemical binding]; other site 1286640009350 active site 1286640009351 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1286640009352 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1286640009353 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1286640009354 DctM-like transporters; Region: DctM; pfam06808 1286640009355 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1286640009356 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1286640009357 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640009358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640009359 NAD(P) binding site [chemical binding]; other site 1286640009360 active site 1286640009361 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1286640009362 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1286640009363 PYR/PP interface [polypeptide binding]; other site 1286640009364 dimer interface [polypeptide binding]; other site 1286640009365 TPP binding site [chemical binding]; other site 1286640009366 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286640009367 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1286640009368 TPP-binding site [chemical binding]; other site 1286640009369 dimer interface [polypeptide binding]; other site 1286640009370 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1286640009371 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1286640009372 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1286640009373 DctM-like transporters; Region: DctM; pfam06808 1286640009374 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1286640009375 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1286640009376 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286640009377 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286640009378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640009379 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1286640009380 dimerization interface [polypeptide binding]; other site 1286640009381 substrate binding pocket [chemical binding]; other site 1286640009382 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1286640009383 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1286640009384 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1286640009385 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286640009386 catalytic residue [active] 1286640009387 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640009388 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640009389 putative DNA binding site [nucleotide binding]; other site 1286640009390 putative Zn2+ binding site [ion binding]; other site 1286640009391 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640009392 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1286640009393 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1286640009394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 1286640009395 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640009396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640009397 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1286640009398 substrate binding pocket [chemical binding]; other site 1286640009399 dimerization interface [polypeptide binding]; other site 1286640009400 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1286640009401 MULE transposase domain; Region: MULE; pfam10551 1286640009402 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1286640009403 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 1286640009404 Uncharacterized conserved protein [Function unknown]; Region: COG1430 1286640009405 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286640009406 DNA-binding site [nucleotide binding]; DNA binding site 1286640009407 RNA-binding motif; other site 1286640009408 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286640009409 DNA-binding site [nucleotide binding]; DNA binding site 1286640009410 RNA-binding motif; other site 1286640009411 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640009412 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1286640009413 dimer interface [polypeptide binding]; other site 1286640009414 active site 1286640009415 metal binding site [ion binding]; metal-binding site 1286640009416 glutathione binding site [chemical binding]; other site 1286640009417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1286640009418 Peptidase M15; Region: Peptidase_M15_3; pfam08291 1286640009419 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1286640009420 DHH family; Region: DHH; pfam01368 1286640009421 DHHA1 domain; Region: DHHA1; pfam02272 1286640009422 homoserine dehydrogenase; Provisional; Region: PRK06349 1286640009423 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1286640009424 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1286640009425 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1286640009426 aminotransferase; Validated; Region: PRK09148 1286640009427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640009428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640009429 homodimer interface [polypeptide binding]; other site 1286640009430 catalytic residue [active] 1286640009431 Short C-terminal domain; Region: SHOCT; pfam09851 1286640009432 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1286640009433 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1286640009434 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1286640009435 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1286640009436 active site 1286640009437 hypothetical protein; Reviewed; Region: PRK00024 1286640009438 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1286640009439 MPN+ (JAMM) motif; other site 1286640009440 Zinc-binding site [ion binding]; other site 1286640009441 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1286640009442 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1286640009443 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286640009444 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640009445 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286640009446 FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997 1286640009447 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 1286640009448 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1286640009449 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1286640009450 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286640009451 catalytic residue [active] 1286640009452 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1286640009453 FeS assembly protein SufD; Region: sufD; TIGR01981 1286640009454 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1286640009455 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1286640009456 Walker A/P-loop; other site 1286640009457 ATP binding site [chemical binding]; other site 1286640009458 Q-loop/lid; other site 1286640009459 ABC transporter signature motif; other site 1286640009460 Walker B; other site 1286640009461 D-loop; other site 1286640009462 H-loop/switch region; other site 1286640009463 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1286640009464 putative ABC transporter; Region: ycf24; CHL00085 1286640009465 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1286640009466 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1286640009467 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286640009468 catalytic residue [active] 1286640009469 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1286640009470 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1286640009471 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377 1286640009472 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1286640009473 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1286640009474 active site 1286640009475 HIGH motif; other site 1286640009476 dimer interface [polypeptide binding]; other site 1286640009477 KMSKS motif; other site 1286640009478 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286640009479 RNA binding surface [nucleotide binding]; other site 1286640009480 Protein of unknown function; Region: DUF3971; pfam13116 1286640009481 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1286640009482 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286640009483 catalytic triad [active] 1286640009484 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1286640009485 dinuclear metal binding motif [ion binding]; other site 1286640009486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2833 1286640009487 dinuclear metal binding motif [ion binding]; other site 1286640009488 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286640009489 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286640009490 helicase 45; Provisional; Region: PTZ00424 1286640009491 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1286640009492 ATP binding site [chemical binding]; other site 1286640009493 Mg++ binding site [ion binding]; other site 1286640009494 motif III; other site 1286640009495 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286640009496 nucleotide binding region [chemical binding]; other site 1286640009497 ATP-binding site [chemical binding]; other site 1286640009498 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_20; cd04679 1286640009499 nudix motif; other site 1286640009500 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1286640009501 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1286640009502 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1286640009503 putative MPT binding site; other site 1286640009504 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1286640009505 Ligand binding site; other site 1286640009506 metal-binding site 1286640009507 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1286640009508 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1286640009509 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1286640009510 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1286640009511 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1286640009512 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1286640009513 metal ion-dependent adhesion site (MIDAS); other site 1286640009514 MoxR-like ATPases [General function prediction only]; Region: COG0714 1286640009515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640009516 Walker A motif; other site 1286640009517 ATP binding site [chemical binding]; other site 1286640009518 Walker B motif; other site 1286640009519 arginine finger; other site 1286640009520 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1286640009521 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1286640009522 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1286640009523 ligand binding site [chemical binding]; other site 1286640009524 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1286640009525 putative active site pocket [active] 1286640009526 cleavage site 1286640009527 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1286640009528 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1286640009529 substrate binding site [chemical binding]; other site 1286640009530 hexamer interface [polypeptide binding]; other site 1286640009531 metal binding site [ion binding]; metal-binding site 1286640009532 Predicted secreted protein [Function unknown]; Region: COG5497 1286640009533 DZF domain; Region: DZF; cl02675 1286640009534 adenylosuccinate lyase; Provisional; Region: PRK07492 1286640009535 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1286640009536 tetramer interface [polypeptide binding]; other site 1286640009537 active site 1286640009538 PilZ domain; Region: PilZ; cl01260 1286640009539 Predicted integral membrane protein [Function unknown]; Region: COG5473 1286640009540 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1286640009541 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286640009542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640009543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640009544 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1286640009545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640009546 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640009547 dimerization interface [polypeptide binding]; other site 1286640009548 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1286640009549 hypothetical protein; Provisional; Region: PRK09262 1286640009550 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1286640009551 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1286640009552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1286640009553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1286640009554 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1286640009555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1286640009556 Uncharacterized conserved protein [Function unknown]; Region: COG5467 1286640009557 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1286640009558 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1286640009559 ATP binding site [chemical binding]; other site 1286640009560 active site 1286640009561 substrate binding site [chemical binding]; other site 1286640009562 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1286640009563 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1286640009564 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1286640009565 putative active site [active] 1286640009566 catalytic triad [active] 1286640009567 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1286640009568 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286640009569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640009570 DNA-binding site [nucleotide binding]; DNA binding site 1286640009571 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640009572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640009573 homodimer interface [polypeptide binding]; other site 1286640009574 catalytic residue [active] 1286640009575 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1286640009576 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1286640009577 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1286640009578 dimerization interface [polypeptide binding]; other site 1286640009579 ATP binding site [chemical binding]; other site 1286640009580 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1286640009581 dimerization interface [polypeptide binding]; other site 1286640009582 ATP binding site [chemical binding]; other site 1286640009583 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1286640009584 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1286640009585 putative GSH binding site [chemical binding]; other site 1286640009586 catalytic residues [active] 1286640009587 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1286640009588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640009589 putative substrate translocation pore; other site 1286640009590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640009591 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1286640009592 putative substrate translocation pore; other site 1286640009593 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 1286640009594 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1286640009595 active site 1286640009596 putative lithium-binding site [ion binding]; other site 1286640009597 substrate binding site [chemical binding]; other site 1286640009598 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1286640009599 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1286640009600 Ligand Binding Site [chemical binding]; other site 1286640009601 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1286640009602 glutaminase; Provisional; Region: PRK00971 1286640009603 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1286640009604 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1286640009605 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286640009606 RNA binding surface [nucleotide binding]; other site 1286640009607 Domain of unknown function DUF87; Region: DUF87; pfam01935 1286640009608 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1286640009609 glutamate racemase; Provisional; Region: PRK00865 1286640009610 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1286640009611 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1286640009612 Predicted membrane protein [Function unknown]; Region: COG1289 1286640009613 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1286640009614 isocitrate dehydrogenase; Validated; Region: PRK08299 1286640009615 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1286640009616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640009617 Protein involved in beta-1,3-glucan synthesis [Carbohydrate transport and metabolism]; Region: SMI1; COG4282 1286640009618 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1286640009619 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1286640009620 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1286640009621 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1286640009622 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1286640009623 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 1286640009624 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1286640009625 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1286640009626 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1286640009627 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1286640009628 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1286640009629 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1286640009630 motif 1; other site 1286640009631 active site 1286640009632 motif 2; other site 1286640009633 motif 3; other site 1286640009634 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1286640009635 recombinase A; Provisional; Region: recA; PRK09354 1286640009636 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1286640009637 hexamer interface [polypeptide binding]; other site 1286640009638 Walker A motif; other site 1286640009639 ATP binding site [chemical binding]; other site 1286640009640 Walker B motif; other site 1286640009641 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286640009642 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1286640009643 substrate binding site [chemical binding]; other site 1286640009644 ATP binding site [chemical binding]; other site 1286640009645 Uncharacterized enzyme involved in pigment biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IndA; COG2313 1286640009646 PAS domain; Region: PAS; smart00091 1286640009647 PAS domain; Region: PAS_9; pfam13426 1286640009648 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1286640009649 PAS domain; Region: PAS; smart00091 1286640009650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640009651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640009652 dimer interface [polypeptide binding]; other site 1286640009653 phosphorylation site [posttranslational modification] 1286640009654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640009655 ATP binding site [chemical binding]; other site 1286640009656 Mg2+ binding site [ion binding]; other site 1286640009657 G-X-G motif; other site 1286640009658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640009659 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640009660 active site 1286640009661 phosphorylation site [posttranslational modification] 1286640009662 intermolecular recognition site; other site 1286640009663 dimerization interface [polypeptide binding]; other site 1286640009664 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1286640009665 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286640009666 catalytic core [active] 1286640009667 Predicted ATPase [General function prediction only]; Region: COG3106 1286640009668 Predicted membrane protein [Function unknown]; Region: COG3768 1286640009669 Domain of unknown function (DUF697); Region: DUF697; cl12064 1286640009670 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1286640009671 catalytic center binding site [active] 1286640009672 ATP binding site [chemical binding]; other site 1286640009673 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1286640009674 homooctamer interface [polypeptide binding]; other site 1286640009675 active site 1286640009676 dihydropteroate synthase; Region: DHPS; TIGR01496 1286640009677 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1286640009678 substrate binding pocket [chemical binding]; other site 1286640009679 dimer interface [polypeptide binding]; other site 1286640009680 inhibitor binding site; inhibition site 1286640009681 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661 1286640009682 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1286640009683 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640009684 catalytic loop [active] 1286640009685 iron binding site [ion binding]; other site 1286640009686 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1286640009687 cytochrome b; Provisional; Region: CYTB; MTH00191 1286640009688 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1286640009689 Qi binding site; other site 1286640009690 intrachain domain interface; other site 1286640009691 interchain domain interface [polypeptide binding]; other site 1286640009692 heme bH binding site [chemical binding]; other site 1286640009693 heme bL binding site [chemical binding]; other site 1286640009694 Qo binding site; other site 1286640009695 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1286640009696 interchain domain interface [polypeptide binding]; other site 1286640009697 intrachain domain interface; other site 1286640009698 Qi binding site; other site 1286640009699 Qo binding site; other site 1286640009700 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1286640009701 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1286640009702 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1286640009703 [2Fe-2S] cluster binding site [ion binding]; other site 1286640009704 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286640009705 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640009706 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1286640009707 Walker A/P-loop; other site 1286640009708 ATP binding site [chemical binding]; other site 1286640009709 Q-loop/lid; other site 1286640009710 ABC transporter signature motif; other site 1286640009711 Walker B; other site 1286640009712 D-loop; other site 1286640009713 H-loop/switch region; other site 1286640009714 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286640009715 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640009716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640009717 Walker A/P-loop; other site 1286640009718 ATP binding site [chemical binding]; other site 1286640009719 Q-loop/lid; other site 1286640009720 ABC transporter signature motif; other site 1286640009721 Walker B; other site 1286640009722 D-loop; other site 1286640009723 H-loop/switch region; other site 1286640009724 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1286640009725 Predicted flavoprotein [General function prediction only]; Region: COG0431 1286640009726 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286640009727 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1286640009728 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1286640009729 DNA binding residues [nucleotide binding] 1286640009730 dimer interface [polypeptide binding]; other site 1286640009731 [2Fe-2S] cluster binding site [ion binding]; other site 1286640009732 Coproporphyrinogen III oxidase [Coenzyme metabolism]; Region: HemF; COG0408 1286640009733 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 1286640009734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3657 1286640009735 Predicted transcriptional regulator [Transcription]; Region: COG3636 1286640009736 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 1286640009737 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1286640009738 mce related protein; Region: MCE; pfam02470 1286640009739 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1286640009740 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1286640009741 Walker A/P-loop; other site 1286640009742 ATP binding site [chemical binding]; other site 1286640009743 Q-loop/lid; other site 1286640009744 ABC transporter signature motif; other site 1286640009745 Walker B; other site 1286640009746 D-loop; other site 1286640009747 H-loop/switch region; other site 1286640009748 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1286640009749 Permease; Region: Permease; pfam02405 1286640009750 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1286640009751 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1286640009752 active site 1286640009753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640009754 putative substrate translocation pore; other site 1286640009755 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1286640009756 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286640009757 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1286640009758 putative active site [active] 1286640009759 putative metal binding site [ion binding]; other site 1286640009760 malic enzyme; Reviewed; Region: PRK12862 1286640009761 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1286640009762 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1286640009763 putative NAD(P) binding site [chemical binding]; other site 1286640009764 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1286640009765 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1286640009766 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640009767 DNA binding residues [nucleotide binding] 1286640009768 dimerization interface [polypeptide binding]; other site 1286640009769 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 1286640009770 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 1286640009771 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1286640009772 putative FMN binding site [chemical binding]; other site 1286640009773 short chain dehydrogenase; Provisional; Region: PRK06198 1286640009774 classical (c) SDRs; Region: SDR_c; cd05233 1286640009775 NAD(P) binding site [chemical binding]; other site 1286640009776 active site 1286640009777 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1286640009778 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640009779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640009780 DNA binding site [nucleotide binding] 1286640009781 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1286640009782 putative ligand binding site [chemical binding]; other site 1286640009783 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1286640009784 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1286640009785 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1286640009786 NAD synthetase; Provisional; Region: PRK13981 1286640009787 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1286640009788 multimer interface [polypeptide binding]; other site 1286640009789 active site 1286640009790 catalytic triad [active] 1286640009791 protein interface 1 [polypeptide binding]; other site 1286640009792 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1286640009793 homodimer interface [polypeptide binding]; other site 1286640009794 NAD binding pocket [chemical binding]; other site 1286640009795 ATP binding pocket [chemical binding]; other site 1286640009796 Mg binding site [ion binding]; other site 1286640009797 active-site loop [active] 1286640009798 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1286640009799 Sulfatase; Region: Sulfatase; pfam00884 1286640009800 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1286640009801 TadE-like protein; Region: TadE; pfam07811 1286640009802 Predicted membrane protein [Function unknown]; Region: COG4655 1286640009803 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 1286640009804 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1286640009805 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1286640009806 glutathione-disulfide reductase, plant; Region: gluta_reduc_2; TIGR01424 1286640009807 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640009808 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286640009809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 1286640009810 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1286640009811 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286640009812 active site 1286640009813 dimer interface [polypeptide binding]; other site 1286640009814 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1286640009815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640009816 motif II; other site 1286640009817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1286640009818 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640009819 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286640009820 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1286640009821 Class II fumarases; Region: Fumarase_classII; cd01362 1286640009822 active site 1286640009823 tetramer interface [polypeptide binding]; other site 1286640009824 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1286640009825 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286640009826 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286640009827 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286640009828 MarR family; Region: MarR_2; pfam12802 1286640009829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1286640009830 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1286640009831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286640009832 FeS/SAM binding site; other site 1286640009833 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1286640009834 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286640009835 EamA-like transporter family; Region: EamA; pfam00892 1286640009836 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1286640009837 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1286640009838 GTP binding site; other site 1286640009839 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1286640009840 Walker A motif; other site 1286640009841 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1286640009842 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1286640009843 ligand binding site [chemical binding]; other site 1286640009844 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1286640009845 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640009846 substrate binding pocket [chemical binding]; other site 1286640009847 membrane-bound complex binding site; other site 1286640009848 hinge residues; other site 1286640009849 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640009850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640009851 dimer interface [polypeptide binding]; other site 1286640009852 conserved gate region; other site 1286640009853 putative PBP binding loops; other site 1286640009854 ABC-ATPase subunit interface; other site 1286640009855 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640009856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640009857 dimer interface [polypeptide binding]; other site 1286640009858 conserved gate region; other site 1286640009859 putative PBP binding loops; other site 1286640009860 ABC-ATPase subunit interface; other site 1286640009861 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 1286640009862 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1286640009863 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1286640009864 putative NAD(P) binding site [chemical binding]; other site 1286640009865 putative active site [active] 1286640009866 Predicted integral membrane protein [Function unknown]; Region: COG5530 1286640009867 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 1286640009868 Tetratricopeptide repeat; Region: TPR_1; pfam00515 1286640009869 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1286640009870 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1286640009871 NAD(P) binding pocket [chemical binding]; other site 1286640009872 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286640009873 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1286640009874 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1286640009875 active site 1286640009876 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640009877 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640009878 putative DNA binding site [nucleotide binding]; other site 1286640009879 putative Zn2+ binding site [ion binding]; other site 1286640009880 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640009881 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1286640009882 putative uracil binding site [chemical binding]; other site 1286640009883 putative active site [active] 1286640009884 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1286640009885 Catalytic site; other site 1286640009886 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1286640009887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640009888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640009889 dimer interface [polypeptide binding]; other site 1286640009890 phosphorylation site [posttranslational modification] 1286640009891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640009892 ATP binding site [chemical binding]; other site 1286640009893 Mg2+ binding site [ion binding]; other site 1286640009894 G-X-G motif; other site 1286640009895 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1286640009896 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1286640009897 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1286640009898 putative dimer interface [polypeptide binding]; other site 1286640009899 active site pocket [active] 1286640009900 putative cataytic base [active] 1286640009901 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1286640009902 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1286640009903 Predicted aspartyl protease [General function prediction only]; Region: COG3577 1286640009904 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1286640009905 catalytic motif [active] 1286640009906 Catalytic residue [active] 1286640009907 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1286640009908 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1286640009909 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286640009910 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286640009911 Walker A/P-loop; other site 1286640009912 ATP binding site [chemical binding]; other site 1286640009913 Q-loop/lid; other site 1286640009914 ABC transporter signature motif; other site 1286640009915 Walker B; other site 1286640009916 D-loop; other site 1286640009917 H-loop/switch region; other site 1286640009918 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640009919 dimerization interface [polypeptide binding]; other site 1286640009920 putative DNA binding site [nucleotide binding]; other site 1286640009921 putative Zn2+ binding site [ion binding]; other site 1286640009922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1286640009923 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640009924 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1286640009925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 1286640009926 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1286640009927 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097 1286640009928 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097 1286640009929 Cache domain; Region: Cache_2; pfam08269 1286640009930 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286640009931 dimerization interface [polypeptide binding]; other site 1286640009932 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286640009933 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286640009934 dimer interface [polypeptide binding]; other site 1286640009935 putative CheW interface [polypeptide binding]; other site 1286640009936 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1286640009937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169 1286640009938 excinuclease ABC subunit B; Provisional; Region: PRK05298 1286640009939 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286640009940 ATP binding site [chemical binding]; other site 1286640009941 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286640009942 nucleotide binding region [chemical binding]; other site 1286640009943 ATP-binding site [chemical binding]; other site 1286640009944 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1286640009945 UvrB/uvrC motif; Region: UVR; pfam02151 1286640009946 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1286640009947 HSP70 interaction site [polypeptide binding]; other site 1286640009948 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286640009949 DNA-binding site [nucleotide binding]; DNA binding site 1286640009950 RNA-binding motif; other site 1286640009951 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1286640009952 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1286640009953 FMN binding site [chemical binding]; other site 1286640009954 active site 1286640009955 catalytic residues [active] 1286640009956 substrate binding site [chemical binding]; other site 1286640009957 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1286640009958 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1286640009959 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1286640009960 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1286640009961 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1286640009962 trimer interface [polypeptide binding]; other site 1286640009963 putative metal binding site [ion binding]; other site 1286640009964 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1286640009965 metal binding site 2 [ion binding]; metal-binding site 1286640009966 putative DNA binding helix; other site 1286640009967 metal binding site 1 [ion binding]; metal-binding site 1286640009968 dimer interface [polypeptide binding]; other site 1286640009969 structural Zn2+ binding site [ion binding]; other site 1286640009970 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1286640009971 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286640009972 ABC-ATPase subunit interface; other site 1286640009973 dimer interface [polypeptide binding]; other site 1286640009974 putative PBP binding regions; other site 1286640009975 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1286640009976 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1286640009977 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 1286640009978 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1286640009979 metal binding site [ion binding]; metal-binding site 1286640009980 Predicted integral membrane protein [Function unknown]; Region: COG5455 1286640009981 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1286640009982 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1286640009983 inhibitor binding site; inhibition site 1286640009984 active site 1286640009985 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 1286640009986 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1286640009987 DctM-like transporters; Region: DctM; pfam06808 1286640009988 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1286640009989 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640009990 Winged helix-turn helix; Region: HTH_29; pfam13551 1286640009991 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640009992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1286640009993 Integrase core domain; Region: rve; pfam00665 1286640009994 Integrase core domain; Region: rve_3; pfam13683 1286640009995 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1286640009996 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1286640009997 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640009998 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640009999 active site 1286640010000 catalytic tetrad [active] 1286640010001 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640010002 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640010003 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286640010004 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1286640010005 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1286640010006 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1286640010007 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1286640010008 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286640010009 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640010010 Walker A/P-loop; other site 1286640010011 ATP binding site [chemical binding]; other site 1286640010012 Q-loop/lid; other site 1286640010013 ABC transporter signature motif; other site 1286640010014 Walker B; other site 1286640010015 D-loop; other site 1286640010016 H-loop/switch region; other site 1286640010017 TOBE domain; Region: TOBE; pfam03459 1286640010018 TOBE domain; Region: TOBE_2; pfam08402 1286640010019 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640010020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640010021 dimer interface [polypeptide binding]; other site 1286640010022 conserved gate region; other site 1286640010023 putative PBP binding loops; other site 1286640010024 ABC-ATPase subunit interface; other site 1286640010025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640010026 dimer interface [polypeptide binding]; other site 1286640010027 conserved gate region; other site 1286640010028 putative PBP binding loops; other site 1286640010029 ABC-ATPase subunit interface; other site 1286640010030 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640010031 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640010032 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640010033 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640010034 DNA binding site [nucleotide binding] 1286640010035 domain linker motif; other site 1286640010036 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1286640010037 ligand binding site [chemical binding]; other site 1286640010038 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 1286640010039 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286640010040 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1286640010041 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1286640010042 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1286640010043 Helix-turn-helix domain; Region: HTH_18; pfam12833 1286640010044 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1286640010045 hydrophobic ligand binding site; other site 1286640010046 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640010047 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1286640010048 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1286640010049 putative acyl-acceptor binding pocket; other site 1286640010050 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286640010051 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 1286640010052 putative NAD(P) binding site [chemical binding]; other site 1286640010053 structural Zn binding site [ion binding]; other site 1286640010054 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 1286640010055 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1286640010056 dimer interface [polypeptide binding]; other site 1286640010057 active site 1286640010058 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 1286640010059 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1286640010060 active site 1286640010061 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 1286640010062 active site 2 [active] 1286640010063 active site 1 [active] 1286640010064 acyl carrier protein; Provisional; Region: PRK06508 1286640010065 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1286640010066 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1286640010067 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640010068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640010069 homodimer interface [polypeptide binding]; other site 1286640010070 catalytic residue [active] 1286640010071 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1286640010072 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1286640010073 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1286640010074 active site 1286640010075 SAM binding site [chemical binding]; other site 1286640010076 homodimer interface [polypeptide binding]; other site 1286640010077 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 1286640010078 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1286640010079 hypothetical protein; Provisional; Region: PRK10621 1286640010080 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286640010081 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1286640010082 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640010083 Walker A/P-loop; other site 1286640010084 ATP binding site [chemical binding]; other site 1286640010085 Q-loop/lid; other site 1286640010086 ABC transporter signature motif; other site 1286640010087 Walker B; other site 1286640010088 D-loop; other site 1286640010089 H-loop/switch region; other site 1286640010090 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640010091 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640010092 Walker A/P-loop; other site 1286640010093 ATP binding site [chemical binding]; other site 1286640010094 Q-loop/lid; other site 1286640010095 ABC transporter signature motif; other site 1286640010096 Walker B; other site 1286640010097 D-loop; other site 1286640010098 H-loop/switch region; other site 1286640010099 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1286640010100 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1286640010101 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640010102 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1286640010103 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640010104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640010105 dimer interface [polypeptide binding]; other site 1286640010106 conserved gate region; other site 1286640010107 putative PBP binding loops; other site 1286640010108 ABC-ATPase subunit interface; other site 1286640010109 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1286640010110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640010111 dimer interface [polypeptide binding]; other site 1286640010112 conserved gate region; other site 1286640010113 putative PBP binding loops; other site 1286640010114 ABC-ATPase subunit interface; other site 1286640010115 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1286640010116 ANTAR domain; Region: ANTAR; pfam03861 1286640010117 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1286640010118 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 1286640010119 ligand binding site [chemical binding]; other site 1286640010120 regulator interaction site; other site 1286640010121 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1286640010122 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1286640010123 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1286640010124 homodimer interface [polypeptide binding]; other site 1286640010125 Walker A motif; other site 1286640010126 ATP binding site [chemical binding]; other site 1286640010127 hydroxycobalamin binding site [chemical binding]; other site 1286640010128 Walker B motif; other site 1286640010129 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1286640010130 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1286640010131 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1286640010132 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1286640010133 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1286640010134 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1286640010135 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1286640010136 homotrimer interface [polypeptide binding]; other site 1286640010137 Walker A motif; other site 1286640010138 GTP binding site [chemical binding]; other site 1286640010139 Walker B motif; other site 1286640010140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 1286640010141 FecR protein; Region: FecR; pfam04773 1286640010142 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1286640010143 CHASE2 domain; Region: CHASE2; pfam05226 1286640010144 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640010145 cyclase homology domain; Region: CHD; cd07302 1286640010146 nucleotidyl binding site; other site 1286640010147 metal binding site [ion binding]; metal-binding site 1286640010148 dimer interface [polypeptide binding]; other site 1286640010149 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286640010150 cobyric acid synthase; Provisional; Region: PRK00784 1286640010151 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1286640010152 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1286640010153 catalytic triad [active] 1286640010154 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1286640010155 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1286640010156 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1286640010157 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1286640010158 Walker A/P-loop; other site 1286640010159 ATP binding site [chemical binding]; other site 1286640010160 Q-loop/lid; other site 1286640010161 ABC transporter signature motif; other site 1286640010162 Walker B; other site 1286640010163 D-loop; other site 1286640010164 H-loop/switch region; other site 1286640010165 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1286640010166 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1286640010167 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1286640010168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640010169 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640010170 dimerization interface [polypeptide binding]; other site 1286640010171 methionine synthase I; Validated; Region: PRK07534 1286640010172 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1286640010173 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1286640010174 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1286640010175 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640010176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640010177 homodimer interface [polypeptide binding]; other site 1286640010178 catalytic residue [active] 1286640010179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1286640010180 YheO-like PAS domain; Region: PAS_6; pfam08348 1286640010181 HTH domain; Region: HTH_22; pfam13309 1286640010182 Predicted periplasmic protein [Function unknown]; Region: COG3698 1286640010183 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1286640010184 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 1286640010185 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 1286640010186 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 1286640010187 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 1286640010188 B12 binding site [chemical binding]; other site 1286640010189 cobalt ligand [ion binding]; other site 1286640010190 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 1286640010191 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1286640010192 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 1286640010193 putative active site [active] 1286640010194 putative cosubstrate binding site; other site 1286640010195 putative substrate binding site [chemical binding]; other site 1286640010196 catalytic site [active] 1286640010197 BA14K-like protein; Region: BA14K; pfam07886 1286640010198 Virulence factor; Region: Virulence_fact; pfam13769 1286640010199 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 1286640010200 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1286640010201 FAD binding site [chemical binding]; other site 1286640010202 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 1286640010203 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 1286640010204 substrate binding pocket [chemical binding]; other site 1286640010205 dimer interface [polypeptide binding]; other site 1286640010206 inhibitor binding site; inhibition site 1286640010207 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 1286640010208 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640010209 catalytic loop [active] 1286640010210 iron binding site [ion binding]; other site 1286640010211 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 1286640010212 AAA domain; Region: AAA_33; pfam13671 1286640010213 P-loop motif; other site 1286640010214 ATP binding site [chemical binding]; other site 1286640010215 Chloramphenicol (Cm) binding site [chemical binding]; other site 1286640010216 catalytic residue [active] 1286640010217 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1286640010218 putative hydrophobic ligand binding site [chemical binding]; other site 1286640010219 CLM binding site; other site 1286640010220 L1 loop; other site 1286640010221 DNA binding site [nucleotide binding] 1286640010222 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640010223 dimerization interface [polypeptide binding]; other site 1286640010224 putative DNA binding site [nucleotide binding]; other site 1286640010225 putative Zn2+ binding site [ion binding]; other site 1286640010226 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640010227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640010228 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640010229 dimerization interface [polypeptide binding]; other site 1286640010230 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286640010231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1286640010232 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1286640010233 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1286640010234 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1286640010235 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1286640010236 putative metal binding site [ion binding]; other site 1286640010237 putative homodimer interface [polypeptide binding]; other site 1286640010238 putative homotetramer interface [polypeptide binding]; other site 1286640010239 putative homodimer-homodimer interface [polypeptide binding]; other site 1286640010240 putative allosteric switch controlling residues; other site 1286640010241 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1286640010242 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1286640010243 conserved cys residue [active] 1286640010244 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640010245 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1286640010246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640010247 active site 1286640010248 phosphorylation site [posttranslational modification] 1286640010249 intermolecular recognition site; other site 1286640010250 dimerization interface [polypeptide binding]; other site 1286640010251 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640010252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640010253 active site 1286640010254 phosphorylation site [posttranslational modification] 1286640010255 intermolecular recognition site; other site 1286640010256 dimerization interface [polypeptide binding]; other site 1286640010257 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1286640010258 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640010259 cyclase homology domain; Region: CHD; cd07302 1286640010260 nucleotidyl binding site; other site 1286640010261 metal binding site [ion binding]; metal-binding site 1286640010262 dimer interface [polypeptide binding]; other site 1286640010263 RibD C-terminal domain; Region: RibD_C; cl17279 1286640010264 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1286640010265 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1286640010266 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1286640010267 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286640010268 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1286640010269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 1286640010270 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1286640010271 transmembrane helices; other site 1286640010272 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1286640010273 TrkA-C domain; Region: TrkA_C; pfam02080 1286640010274 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1286640010275 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 1286640010276 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1286640010277 catalytic residue [active] 1286640010278 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286640010279 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286640010280 active site 1286640010281 Terminase-like family; Region: Terminase_6; pfam03237 1286640010282 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 1286640010283 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1286640010284 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1286640010285 MULE transposase domain; Region: MULE; pfam10551 1286640010286 BA14K-like protein; Region: BA14K; pfam07886 1286640010287 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1286640010288 DnaA box-binding interface [nucleotide binding]; other site 1286640010289 Predicted transcriptional regulator [Transcription]; Region: COG2932 1286640010290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640010291 non-specific DNA binding site [nucleotide binding]; other site 1286640010292 salt bridge; other site 1286640010293 sequence-specific DNA binding site [nucleotide binding]; other site 1286640010294 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1286640010295 Catalytic site [active] 1286640010296 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1286640010297 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1286640010298 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1286640010299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1286640010300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286640010301 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1286640010302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640010303 DNA binding residues [nucleotide binding] 1286640010304 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1286640010305 FecR protein; Region: FecR; pfam04773 1286640010306 Secretin and TonB N terminus short domain; Region: STN; smart00965 1286640010307 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1286640010308 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286640010309 N-terminal plug; other site 1286640010310 ligand-binding site [chemical binding]; other site 1286640010311 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1286640010312 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640010313 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1286640010314 Walker A/P-loop; other site 1286640010315 ATP binding site [chemical binding]; other site 1286640010316 Q-loop/lid; other site 1286640010317 ABC transporter signature motif; other site 1286640010318 Walker B; other site 1286640010319 D-loop; other site 1286640010320 H-loop/switch region; other site 1286640010321 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1286640010322 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640010323 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1286640010324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 1286640010325 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 1286640010326 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1286640010327 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1286640010328 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1286640010329 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1286640010330 nudix motif; other site 1286640010331 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1286640010332 putative catalytic site [active] 1286640010333 putative phosphate binding site [ion binding]; other site 1286640010334 putative metal binding site [ion binding]; other site 1286640010335 TIGR02594 family protein; Region: TIGR02594 1286640010336 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1286640010337 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1286640010338 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 1286640010339 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1286640010340 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1286640010341 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1286640010342 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640010343 cyclase homology domain; Region: CHD; cd07302 1286640010344 nucleotidyl binding site; other site 1286640010345 metal binding site [ion binding]; metal-binding site 1286640010346 dimer interface [polypeptide binding]; other site 1286640010347 Predicted integral membrane protein [Function unknown]; Region: COG5616 1286640010348 TPR repeat; Region: TPR_11; pfam13414 1286640010349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640010350 binding surface 1286640010351 TPR motif; other site 1286640010352 cell division protein FtsZ; Provisional; Region: PRK13018 1286640010353 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1286640010354 nucleotide binding site [chemical binding]; other site 1286640010355 SulA interaction site; other site 1286640010356 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1286640010357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640010358 active site 1286640010359 motif I; other site 1286640010360 motif II; other site 1286640010361 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1286640010362 AAA ATPase domain; Region: AAA_16; pfam13191 1286640010363 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286640010364 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1286640010365 Walker A/P-loop; other site 1286640010366 ATP binding site [chemical binding]; other site 1286640010367 Q-loop/lid; other site 1286640010368 ABC transporter signature motif; other site 1286640010369 Walker B; other site 1286640010370 D-loop; other site 1286640010371 H-loop/switch region; other site 1286640010372 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286640010373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640010374 dimer interface [polypeptide binding]; other site 1286640010375 conserved gate region; other site 1286640010376 putative PBP binding loops; other site 1286640010377 ABC-ATPase subunit interface; other site 1286640010378 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286640010379 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1286640010380 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286640010381 DNA-binding site [nucleotide binding]; DNA binding site 1286640010382 RNA-binding motif; other site 1286640010383 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1286640010384 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640010385 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1286640010386 C-terminal domain interface [polypeptide binding]; other site 1286640010387 GSH binding site (G-site) [chemical binding]; other site 1286640010388 dimer interface [polypeptide binding]; other site 1286640010389 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1286640010390 N-terminal domain interface [polypeptide binding]; other site 1286640010391 dimer interface [polypeptide binding]; other site 1286640010392 substrate binding pocket (H-site) [chemical binding]; other site 1286640010393 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640010394 active site 1286640010395 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640010396 catalytic tetrad [active] 1286640010397 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1286640010398 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640010399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640010400 homodimer interface [polypeptide binding]; other site 1286640010401 catalytic residue [active] 1286640010402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1286640010403 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286640010404 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1286640010405 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1286640010406 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640010407 cyclase homology domain; Region: CHD; cd07302 1286640010408 nucleotidyl binding site; other site 1286640010409 metal binding site [ion binding]; metal-binding site 1286640010410 dimer interface [polypeptide binding]; other site 1286640010411 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1286640010412 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1286640010413 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1286640010414 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640010415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640010416 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1286640010417 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640010418 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1286640010419 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286640010420 Walker A/P-loop; other site 1286640010421 ATP binding site [chemical binding]; other site 1286640010422 Q-loop/lid; other site 1286640010423 ABC transporter signature motif; other site 1286640010424 Walker B; other site 1286640010425 D-loop; other site 1286640010426 H-loop/switch region; other site 1286640010427 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286640010428 FtsX-like permease family; Region: FtsX; pfam02687 1286640010429 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1286640010430 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1286640010431 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1286640010432 Catalytic site; other site 1286640010433 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1286640010434 Phosphotransferase enzyme family; Region: APH; pfam01636 1286640010435 putative active site [active] 1286640010436 putative substrate binding site [chemical binding]; other site 1286640010437 ATP binding site [chemical binding]; other site 1286640010438 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 1286640010439 benzoate transport; Region: 2A0115; TIGR00895 1286640010440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640010441 putative substrate translocation pore; other site 1286640010442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640010443 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286640010444 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286640010445 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286640010446 putative active site [active] 1286640010447 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1286640010448 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640010449 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640010450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640010451 putative DNA binding site [nucleotide binding]; other site 1286640010452 putative Zn2+ binding site [ion binding]; other site 1286640010453 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640010454 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1286640010455 aspartate racemase; Region: asp_race; TIGR00035 1286640010456 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286640010457 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286640010458 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1286640010459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640010460 NAD(P) binding site [chemical binding]; other site 1286640010461 active site 1286640010462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 1286640010463 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286640010464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640010465 DNA-binding site [nucleotide binding]; DNA binding site 1286640010466 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640010467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640010468 homodimer interface [polypeptide binding]; other site 1286640010469 catalytic residue [active] 1286640010470 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1286640010471 active site 1286640010472 hydrophilic channel; other site 1286640010473 dimerization interface [polypeptide binding]; other site 1286640010474 catalytic residues [active] 1286640010475 active site lid [active] 1286640010476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 1286640010477 EF-hand domain pair; Region: EF_hand_5; pfam13499 1286640010478 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1286640010479 Ca2+ binding site [ion binding]; other site 1286640010480 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 1286640010481 Zn binding site [ion binding]; other site 1286640010482 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1286640010483 YcaO-like family; Region: YcaO; pfam02624 1286640010484 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1286640010485 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1286640010486 cyclase homology domain; Region: CHD; cd07302 1286640010487 nucleotidyl binding site; other site 1286640010488 metal binding site [ion binding]; metal-binding site 1286640010489 dimer interface [polypeptide binding]; other site 1286640010490 Predicted ATPase [General function prediction only]; Region: COG3899 1286640010491 AAA ATPase domain; Region: AAA_16; pfam13191 1286640010492 Predicted ATPase [General function prediction only]; Region: COG3903 1286640010493 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 1286640010494 AAA domain; Region: AAA_30; pfam13604 1286640010495 Family description; Region: UvrD_C_2; pfam13538 1286640010496 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1286640010497 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1286640010498 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1286640010499 Predicted transcriptional regulator [Transcription]; Region: COG4190 1286640010500 Helix-turn-helix domain; Region: HTH_20; pfam12840 1286640010501 putative DNA binding site [nucleotide binding]; other site 1286640010502 putative Zn2+ binding site [ion binding]; other site 1286640010503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 1286640010504 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1286640010505 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1286640010506 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1286640010507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286640010508 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640010509 DNA binding residues [nucleotide binding] 1286640010510 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1286640010511 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 1286640010512 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 1286640010513 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1286640010514 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 1286640010515 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1286640010516 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286640010517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640010518 S-adenosylmethionine binding site [chemical binding]; other site 1286640010519 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286640010520 DNA-binding site [nucleotide binding]; DNA binding site 1286640010521 RNA-binding motif; other site 1286640010522 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640010523 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640010524 active site 1286640010525 catalytic tetrad [active] 1286640010526 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1286640010527 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1286640010528 putative valine binding site [chemical binding]; other site 1286640010529 dimer interface [polypeptide binding]; other site 1286640010530 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1286640010531 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 1286640010532 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286640010533 PYR/PP interface [polypeptide binding]; other site 1286640010534 dimer interface [polypeptide binding]; other site 1286640010535 TPP binding site [chemical binding]; other site 1286640010536 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286640010537 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1286640010538 TPP-binding site [chemical binding]; other site 1286640010539 dimer interface [polypeptide binding]; other site 1286640010540 HAS barrel domain; Region: HAS-barrel; pfam09378 1286640010541 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1286640010542 Domain of unknown function DUF87; Region: DUF87; pfam01935 1286640010543 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1286640010544 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1286640010545 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1286640010546 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1286640010547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640010548 motif II; other site 1286640010549 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286640010550 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286640010551 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1286640010552 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1286640010553 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286640010554 protein binding site [polypeptide binding]; other site 1286640010555 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286640010556 protein binding site [polypeptide binding]; other site 1286640010557 Uncharacterized conserved protein [Function unknown]; Region: COG3603 1286640010558 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1286640010559 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1286640010560 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1286640010561 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1286640010562 HflK protein; Region: hflK; TIGR01933 1286640010563 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1286640010564 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1286640010565 folate binding site [chemical binding]; other site 1286640010566 NADP+ binding site [chemical binding]; other site 1286640010567 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640010568 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1286640010569 putative C-terminal domain interface [polypeptide binding]; other site 1286640010570 putative GSH binding site (G-site) [chemical binding]; other site 1286640010571 putative dimer interface [polypeptide binding]; other site 1286640010572 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1286640010573 dimer interface [polypeptide binding]; other site 1286640010574 N-terminal domain interface [polypeptide binding]; other site 1286640010575 putative substrate binding pocket (H-site) [chemical binding]; other site 1286640010576 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1286640010577 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1286640010578 dimerization interface [polypeptide binding]; other site 1286640010579 active site 1286640010580 Uncharacterized conserved protein [Function unknown]; Region: COG5502 1286640010581 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 1286640010582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 1286640010583 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 1286640010584 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 1286640010585 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1286640010586 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1286640010587 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286640010588 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 1286640010589 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1286640010590 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286640010591 FAD binding domain; Region: FAD_binding_4; pfam01565 1286640010592 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 1286640010593 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1286640010594 Protein export membrane protein; Region: SecD_SecF; cl14618 1286640010595 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286640010596 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640010597 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640010598 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1286640010599 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1286640010600 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1286640010601 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1286640010602 Part of AAA domain; Region: AAA_19; pfam13245 1286640010603 Family description; Region: UvrD_C_2; pfam13538 1286640010604 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286640010605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640010606 Coenzyme A binding pocket [chemical binding]; other site 1286640010607 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926 1286640010608 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286640010609 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640010610 metal binding site [ion binding]; metal-binding site 1286640010611 active site 1286640010612 I-site; other site 1286640010613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 1286640010614 CreA protein; Region: CreA; pfam05981 1286640010615 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 1286640010616 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1286640010617 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286640010618 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1286640010619 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1286640010620 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1286640010621 putative CheA interaction surface; other site 1286640010622 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286640010623 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286640010624 dimer interface [polypeptide binding]; other site 1286640010625 putative CheW interface [polypeptide binding]; other site 1286640010626 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1286640010627 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1286640010628 Cu(I) binding site [ion binding]; other site 1286640010629 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 1286640010630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640010631 S-adenosylmethionine binding site [chemical binding]; other site 1286640010632 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1286640010633 catalytic nucleophile [active] 1286640010634 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1286640010635 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1286640010636 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1286640010637 active site 1286640010638 Nuclear pore component; Region: Nup88; pfam10168 1286640010639 Predicted membrane protein [Function unknown]; Region: COG4541 1286640010640 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1286640010641 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1286640010642 oligomerization interface [polypeptide binding]; other site 1286640010643 active site 1286640010644 metal binding site [ion binding]; metal-binding site 1286640010645 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1286640010646 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1286640010647 active site 1286640010648 ATP-binding site [chemical binding]; other site 1286640010649 pantoate-binding site; other site 1286640010650 HXXH motif; other site 1286640010651 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1286640010652 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640010653 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1286640010654 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1286640010655 nucleotide binding pocket [chemical binding]; other site 1286640010656 K-X-D-G motif; other site 1286640010657 catalytic site [active] 1286640010658 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1286640010659 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1286640010660 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1286640010661 Dimer interface [polypeptide binding]; other site 1286640010662 BRCT sequence motif; other site 1286640010663 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1286640010664 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1286640010665 Walker A/P-loop; other site 1286640010666 ATP binding site [chemical binding]; other site 1286640010667 Q-loop/lid; other site 1286640010668 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1286640010669 ABC transporter signature motif; other site 1286640010670 Walker B; other site 1286640010671 D-loop; other site 1286640010672 H-loop/switch region; other site 1286640010673 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 1286640010674 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 1286640010675 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1286640010676 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1286640010677 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1286640010678 nucleotide binding site [chemical binding]; other site 1286640010679 SulA interaction site; other site 1286640010680 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1286640010681 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1286640010682 Cell division protein FtsA; Region: FtsA; smart00842 1286640010683 Cell division protein FtsA; Region: FtsA; pfam14450 1286640010684 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1286640010685 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1286640010686 Cell division protein FtsQ; Region: FtsQ; pfam03799 1286640010687 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1286640010688 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1286640010689 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1286640010690 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1286640010691 amphipathic channel; other site 1286640010692 Asn-Pro-Ala signature motifs; other site 1286640010693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640010694 metabolite-proton symporter; Region: 2A0106; TIGR00883 1286640010695 putative substrate translocation pore; other site 1286640010696 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1286640010697 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1286640010698 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1286640010699 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1286640010700 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286640010701 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286640010702 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1286640010703 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1286640010704 homodimer interface [polypeptide binding]; other site 1286640010705 active site 1286640010706 cell division protein FtsW; Region: ftsW; TIGR02614 1286640010707 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 1286640010708 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286640010709 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286640010710 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1286640010711 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1286640010712 Mg++ binding site [ion binding]; other site 1286640010713 putative catalytic motif [active] 1286640010714 putative substrate binding site [chemical binding]; other site 1286640010715 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1286640010716 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1286640010717 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286640010718 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286640010719 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1286640010720 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1286640010721 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286640010722 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286640010723 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1286640010724 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286640010725 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286640010726 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 1286640010727 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1286640010728 MraW methylase family; Region: Methyltransf_5; cl17771 1286640010729 cell division protein MraZ; Reviewed; Region: PRK00326 1286640010730 MraZ protein; Region: MraZ; pfam02381 1286640010731 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640010732 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1286640010733 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286640010734 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286640010735 catalytic residue [active] 1286640010736 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1286640010737 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286640010738 amidase catalytic site [active] 1286640010739 Zn binding residues [ion binding]; other site 1286640010740 substrate binding site [chemical binding]; other site 1286640010741 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640010742 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1286640010743 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1286640010744 putative metal binding site [ion binding]; other site 1286640010745 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1286640010746 HSP70 interaction site [polypeptide binding]; other site 1286640010747 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 1286640010748 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 1286640010749 active site 1286640010750 ADP/pyrophosphate binding site [chemical binding]; other site 1286640010751 allosteric effector site; other site 1286640010752 dimerization interface [polypeptide binding]; other site 1286640010753 fructose-1,6-bisphosphate binding site; other site 1286640010754 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286640010755 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1286640010756 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286640010757 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286640010758 catalytic residue [active] 1286640010759 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286640010760 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286640010761 S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379 1286640010762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640010763 S-adenosylmethionine binding site [chemical binding]; other site 1286640010764 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1286640010765 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 1286640010766 active site 1286640010767 lytic murein transglycosylase; Region: MltB_2; TIGR02283 1286640010768 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1286640010769 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640010770 EamA-like transporter family; Region: EamA; cl17759 1286640010771 EamA-like transporter family; Region: EamA; pfam00892 1286640010772 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1286640010773 FAD binding site [chemical binding]; other site 1286640010774 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640010775 dimerization interface [polypeptide binding]; other site 1286640010776 putative DNA binding site [nucleotide binding]; other site 1286640010777 putative Zn2+ binding site [ion binding]; other site 1286640010778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640010779 S-adenosylmethionine binding site [chemical binding]; other site 1286640010780 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1286640010781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640010782 Walker A/P-loop; other site 1286640010783 ATP binding site [chemical binding]; other site 1286640010784 Q-loop/lid; other site 1286640010785 ABC transporter signature motif; other site 1286640010786 Walker B; other site 1286640010787 D-loop; other site 1286640010788 H-loop/switch region; other site 1286640010789 ABC transporter; Region: ABC_tran_2; pfam12848 1286640010790 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286640010791 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1286640010792 B1 nucleotide binding pocket [chemical binding]; other site 1286640010793 B2 nucleotide binding pocket [chemical binding]; other site 1286640010794 CAS motifs; other site 1286640010795 active site 1286640010796 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1286640010797 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286640010798 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286640010799 EamA-like transporter family; Region: EamA; pfam00892 1286640010800 thiamine pyrophosphate protein; Validated; Region: PRK08199 1286640010801 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286640010802 PYR/PP interface [polypeptide binding]; other site 1286640010803 dimer interface [polypeptide binding]; other site 1286640010804 TPP binding site [chemical binding]; other site 1286640010805 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286640010806 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1286640010807 TPP-binding site [chemical binding]; other site 1286640010808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 1286640010809 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1286640010810 active site 1286640010811 catalytic residues [active] 1286640010812 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640010813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1286640010814 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286640010815 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286640010816 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640010817 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1286640010818 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1286640010819 P-loop; other site 1286640010820 Magnesium ion binding site [ion binding]; other site 1286640010821 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1286640010822 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 1286640010823 putative active site [active] 1286640010824 metal binding site [ion binding]; metal-binding site 1286640010825 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1286640010826 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 1286640010827 NAD(P) binding site [chemical binding]; other site 1286640010828 catalytic residues [active] 1286640010829 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1286640010830 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1286640010831 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 1286640010832 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 1286640010833 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286640010834 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286640010835 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286640010836 putative active site [active] 1286640010837 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1286640010838 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286640010839 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640010840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640010841 dimer interface [polypeptide binding]; other site 1286640010842 conserved gate region; other site 1286640010843 putative PBP binding loops; other site 1286640010844 ABC-ATPase subunit interface; other site 1286640010845 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640010846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640010847 dimer interface [polypeptide binding]; other site 1286640010848 conserved gate region; other site 1286640010849 putative PBP binding loops; other site 1286640010850 ABC-ATPase subunit interface; other site 1286640010851 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286640010852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640010853 Walker A/P-loop; other site 1286640010854 ATP binding site [chemical binding]; other site 1286640010855 Q-loop/lid; other site 1286640010856 ABC transporter signature motif; other site 1286640010857 Walker B; other site 1286640010858 D-loop; other site 1286640010859 H-loop/switch region; other site 1286640010860 TOBE domain; Region: TOBE_2; pfam08402 1286640010861 riboflavin synthase subunit beta; Provisional; Region: PRK12419 1286640010862 active site 1286640010863 homopentamer interface [polypeptide binding]; other site 1286640010864 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286640010865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640010866 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640010867 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 1286640010868 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286640010869 N-terminal plug; other site 1286640010870 ligand-binding site [chemical binding]; other site 1286640010871 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1286640010872 MULE transposase domain; Region: MULE; pfam10551 1286640010873 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1286640010874 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1286640010875 substrate binding site [chemical binding]; other site 1286640010876 dimer interface [polypeptide binding]; other site 1286640010877 triosephosphate isomerase; Provisional; Region: PRK14565 1286640010878 catalytic triad [active] 1286640010879 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1286640010880 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1286640010881 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286640010882 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1286640010883 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 1286640010884 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1286640010885 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640010886 active site 1286640010887 motif I; other site 1286640010888 motif II; other site 1286640010889 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1286640010890 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1286640010891 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286640010892 nucleotide binding site [chemical binding]; other site 1286640010893 Uncharacterized conserved protein [Function unknown]; Region: COG3347 1286640010894 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1286640010895 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 1286640010896 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1286640010897 intersubunit interface [polypeptide binding]; other site 1286640010898 active site 1286640010899 Zn2+ binding site [ion binding]; other site 1286640010900 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1286640010901 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1286640010902 putative ligand binding site [chemical binding]; other site 1286640010903 putative NAD binding site [chemical binding]; other site 1286640010904 catalytic site [active] 1286640010905 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1286640010906 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1286640010907 putative N- and C-terminal domain interface [polypeptide binding]; other site 1286640010908 putative active site [active] 1286640010909 MgATP binding site [chemical binding]; other site 1286640010910 catalytic site [active] 1286640010911 metal binding site [ion binding]; metal-binding site 1286640010912 putative xylulose binding site [chemical binding]; other site 1286640010913 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286640010914 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1286640010915 Walker A/P-loop; other site 1286640010916 ATP binding site [chemical binding]; other site 1286640010917 Q-loop/lid; other site 1286640010918 ABC transporter signature motif; other site 1286640010919 Walker B; other site 1286640010920 D-loop; other site 1286640010921 H-loop/switch region; other site 1286640010922 TOBE domain; Region: TOBE_2; pfam08402 1286640010923 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286640010924 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640010925 Walker A/P-loop; other site 1286640010926 ATP binding site [chemical binding]; other site 1286640010927 Q-loop/lid; other site 1286640010928 ABC transporter signature motif; other site 1286640010929 Walker B; other site 1286640010930 D-loop; other site 1286640010931 H-loop/switch region; other site 1286640010932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286640010933 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640010934 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1286640010935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640010936 dimer interface [polypeptide binding]; other site 1286640010937 conserved gate region; other site 1286640010938 putative PBP binding loops; other site 1286640010939 ABC-ATPase subunit interface; other site 1286640010940 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640010941 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640010942 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286640010943 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286640010944 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640010945 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640010946 DNA binding residues [nucleotide binding] 1286640010947 dimerization interface [polypeptide binding]; other site 1286640010948 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286640010949 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1286640010950 Walker A/P-loop; other site 1286640010951 ATP binding site [chemical binding]; other site 1286640010952 Q-loop/lid; other site 1286640010953 ABC transporter signature motif; other site 1286640010954 Walker B; other site 1286640010955 D-loop; other site 1286640010956 H-loop/switch region; other site 1286640010957 TOBE domain; Region: TOBE_2; pfam08402 1286640010958 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1286640010959 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286640010960 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640010961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640010962 putative PBP binding loops; other site 1286640010963 ABC-ATPase subunit interface; other site 1286640010964 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640010965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640010966 dimer interface [polypeptide binding]; other site 1286640010967 conserved gate region; other site 1286640010968 putative PBP binding loops; other site 1286640010969 ABC-ATPase subunit interface; other site 1286640010970 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640010971 classical (c) SDRs; Region: SDR_c; cd05233 1286640010972 NAD(P) binding site [chemical binding]; other site 1286640010973 active site 1286640010974 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1286640010975 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1286640010976 conserved cys residue [active] 1286640010977 Uncharacterized conserved protein [Function unknown]; Region: COG3246 1286640010978 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531 1286640010979 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1286640010980 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286640010981 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1286640010982 active site 1286640010983 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286640010984 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286640010985 active site 1286640010986 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1286640010987 CoA binding domain; Region: CoA_binding_2; pfam13380 1286640010988 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1286640010989 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1286640010990 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 1286640010991 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286640010992 substrate binding site [chemical binding]; other site 1286640010993 oxyanion hole (OAH) forming residues; other site 1286640010994 trimer interface [polypeptide binding]; other site 1286640010995 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640010996 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1286640010997 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640010998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640010999 dimer interface [polypeptide binding]; other site 1286640011000 conserved gate region; other site 1286640011001 ABC-ATPase subunit interface; other site 1286640011002 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286640011003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011004 dimer interface [polypeptide binding]; other site 1286640011005 conserved gate region; other site 1286640011006 ABC-ATPase subunit interface; other site 1286640011007 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1286640011008 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640011009 Walker A/P-loop; other site 1286640011010 ATP binding site [chemical binding]; other site 1286640011011 Q-loop/lid; other site 1286640011012 ABC transporter signature motif; other site 1286640011013 Walker B; other site 1286640011014 D-loop; other site 1286640011015 H-loop/switch region; other site 1286640011016 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640011017 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640011018 Walker A/P-loop; other site 1286640011019 ATP binding site [chemical binding]; other site 1286640011020 Q-loop/lid; other site 1286640011021 ABC transporter signature motif; other site 1286640011022 Walker B; other site 1286640011023 D-loop; other site 1286640011024 H-loop/switch region; other site 1286640011025 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640011026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640011027 sequence-specific DNA binding site [nucleotide binding]; other site 1286640011028 salt bridge; other site 1286640011029 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640011030 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1286640011031 Predicted acyl esterases [General function prediction only]; Region: COG2936 1286640011032 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286640011033 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1286640011034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 1286640011035 ACT domain; Region: ACT_3; pfam10000 1286640011036 Family description; Region: ACT_7; pfam13840 1286640011037 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1286640011038 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640011039 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640011040 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1286640011041 putative substrate binding pocket [chemical binding]; other site 1286640011042 dimerization interface [polypeptide binding]; other site 1286640011043 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1286640011044 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286640011045 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286640011046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640011047 Walker A/P-loop; other site 1286640011048 ATP binding site [chemical binding]; other site 1286640011049 Q-loop/lid; other site 1286640011050 ABC transporter signature motif; other site 1286640011051 Walker B; other site 1286640011052 D-loop; other site 1286640011053 H-loop/switch region; other site 1286640011054 TOBE domain; Region: TOBE_2; pfam08402 1286640011055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011056 dimer interface [polypeptide binding]; other site 1286640011057 conserved gate region; other site 1286640011058 putative PBP binding loops; other site 1286640011059 ABC-ATPase subunit interface; other site 1286640011060 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640011061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011062 dimer interface [polypeptide binding]; other site 1286640011063 conserved gate region; other site 1286640011064 putative PBP binding loops; other site 1286640011065 ABC-ATPase subunit interface; other site 1286640011066 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1286640011067 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1286640011068 tetrameric interface [polypeptide binding]; other site 1286640011069 NAD binding site [chemical binding]; other site 1286640011070 catalytic residues [active] 1286640011071 substrate binding site [chemical binding]; other site 1286640011072 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 1286640011073 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286640011074 N-terminal plug; other site 1286640011075 ligand-binding site [chemical binding]; other site 1286640011076 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 1286640011077 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1286640011078 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1286640011079 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1286640011080 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1286640011081 putative ligand binding residues [chemical binding]; other site 1286640011082 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 1286640011083 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640011084 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640011085 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1286640011086 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1286640011087 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1286640011088 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640011089 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640011090 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1286640011091 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1286640011092 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640011093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640011094 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286640011095 dimerization interface [polypeptide binding]; other site 1286640011096 Predicted membrane protein [Function unknown]; Region: COG4425 1286640011097 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1286640011098 methionine gamma-lyase; Validated; Region: PRK07049 1286640011099 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286640011100 homodimer interface [polypeptide binding]; other site 1286640011101 substrate-cofactor binding pocket; other site 1286640011102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640011103 catalytic residue [active] 1286640011104 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 1286640011105 dimer interface [polypeptide binding]; other site 1286640011106 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640011107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640011108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640011109 enoyl-CoA hydratase; Provisional; Region: PRK05980 1286640011110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286640011111 substrate binding site [chemical binding]; other site 1286640011112 oxyanion hole (OAH) forming residues; other site 1286640011113 trimer interface [polypeptide binding]; other site 1286640011114 Predicted integral membrane protein [Function unknown]; Region: COG5500 1286640011115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 1286640011116 Putative glucoamylase; Region: Glycoamylase; pfam10091 1286640011117 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 1286640011118 Uncharacterized conserved protein [Function unknown]; Region: COG1944 1286640011119 YcaO-like family; Region: YcaO; pfam02624 1286640011120 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1286640011121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640011122 TPR motif; other site 1286640011123 binding surface 1286640011124 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 1286640011125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640011126 Coenzyme A binding pocket [chemical binding]; other site 1286640011127 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1286640011128 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1286640011129 active site 1286640011130 substrate binding site [chemical binding]; other site 1286640011131 FMN binding site [chemical binding]; other site 1286640011132 putative catalytic residues [active] 1286640011133 topology modulation protein; Reviewed; Region: PRK08118 1286640011134 AAA domain; Region: AAA_17; pfam13207 1286640011135 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1286640011136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640011137 motif II; other site 1286640011138 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286640011139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640011140 Coenzyme A binding pocket [chemical binding]; other site 1286640011141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 1286640011142 replicative DNA helicase; Provisional; Region: PRK05973 1286640011143 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 1286640011144 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1286640011145 dimer interface [polypeptide binding]; other site 1286640011146 substrate binding site [chemical binding]; other site 1286640011147 metal binding site [ion binding]; metal-binding site 1286640011148 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1286640011149 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1286640011150 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 1286640011151 Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353 1286640011152 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1286640011153 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1286640011154 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 1286640011155 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1286640011156 Uncharacterized conserved protein [Function unknown]; Region: COG5507 1286640011157 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286640011158 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286640011159 catalytic residue [active] 1286640011160 Uncharacterized conserved protein [Function unknown]; Region: COG4274 1286640011161 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1286640011162 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1286640011163 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1286640011164 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1286640011165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286640011166 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1286640011167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640011168 DNA binding residues [nucleotide binding] 1286640011169 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1286640011170 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286640011171 NAD(P) binding site [chemical binding]; other site 1286640011172 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1286640011173 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1286640011174 substrate-cofactor binding pocket; other site 1286640011175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640011176 catalytic residue [active] 1286640011177 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1286640011178 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286640011179 ATP binding site [chemical binding]; other site 1286640011180 putative Mg++ binding site [ion binding]; other site 1286640011181 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286640011182 nucleotide binding region [chemical binding]; other site 1286640011183 ATP-binding site [chemical binding]; other site 1286640011184 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1286640011185 HRDC domain; Region: HRDC; pfam00570 1286640011186 DNA primase; Validated; Region: dnaG; PRK05667 1286640011187 CHC2 zinc finger; Region: zf-CHC2; cl17510 1286640011188 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1286640011189 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1286640011190 active site 1286640011191 metal binding site [ion binding]; metal-binding site 1286640011192 interdomain interaction site; other site 1286640011193 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1286640011194 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1286640011195 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1286640011196 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1286640011197 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1286640011198 catalytic site [active] 1286640011199 subunit interface [polypeptide binding]; other site 1286640011200 LysR family transcriptional regulator; Provisional; Region: PRK14997 1286640011201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640011202 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640011203 putative effector binding pocket; other site 1286640011204 dimerization interface [polypeptide binding]; other site 1286640011205 short chain dehydrogenase; Provisional; Region: PRK06500 1286640011206 classical (c) SDRs; Region: SDR_c; cd05233 1286640011207 NAD(P) binding site [chemical binding]; other site 1286640011208 active site 1286640011209 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1286640011210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1286640011211 aspartate aminotransferase; Provisional; Region: PRK05764 1286640011212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640011213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640011214 homodimer interface [polypeptide binding]; other site 1286640011215 catalytic residue [active] 1286640011216 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1286640011217 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1286640011218 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1286640011219 EamA-like transporter family; Region: EamA; pfam00892 1286640011220 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286640011221 DNA-binding site [nucleotide binding]; DNA binding site 1286640011222 RNA-binding motif; other site 1286640011223 BA14K-like protein; Region: BA14K; pfam07886 1286640011224 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1286640011225 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1286640011226 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286640011227 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1286640011228 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286640011229 MarR family; Region: MarR_2; pfam12802 1286640011230 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640011231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640011232 active site 1286640011233 phosphorylation site [posttranslational modification] 1286640011234 intermolecular recognition site; other site 1286640011235 dimerization interface [polypeptide binding]; other site 1286640011236 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640011237 DNA binding site [nucleotide binding] 1286640011238 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640011239 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1286640011240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1286640011241 dimer interface [polypeptide binding]; other site 1286640011242 phosphorylation site [posttranslational modification] 1286640011243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640011244 ATP binding site [chemical binding]; other site 1286640011245 Mg2+ binding site [ion binding]; other site 1286640011246 G-X-G motif; other site 1286640011247 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1286640011248 dimer interface [polypeptide binding]; other site 1286640011249 putative tRNA-binding site [nucleotide binding]; other site 1286640011250 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1286640011251 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1286640011252 Uncharacterized conserved protein [Function unknown]; Region: COG5465 1286640011253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1286640011254 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1286640011255 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1286640011256 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1286640011257 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1286640011258 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1286640011259 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1286640011260 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1286640011261 active site 1286640011262 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1286640011263 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1286640011264 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286640011265 active site 1286640011266 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1286640011267 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1286640011268 tetramer interface [polypeptide binding]; other site 1286640011269 active site 1286640011270 Mg2+/Mn2+ binding site [ion binding]; other site 1286640011271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 1286640011272 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1286640011273 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286640011274 NAD(P) binding site [chemical binding]; other site 1286640011275 catalytic residues [active] 1286640011276 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1286640011277 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286640011278 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1286640011279 benzoate transporter; Region: benE; TIGR00843 1286640011280 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1286640011281 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1286640011282 5S rRNA interface [nucleotide binding]; other site 1286640011283 CTC domain interface [polypeptide binding]; other site 1286640011284 L16 interface [polypeptide binding]; other site 1286640011285 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1286640011286 putative active site [active] 1286640011287 catalytic residue [active] 1286640011288 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 1286640011289 GTP-binding protein YchF; Reviewed; Region: PRK09601 1286640011290 YchF GTPase; Region: YchF; cd01900 1286640011291 G1 box; other site 1286640011292 GTP/Mg2+ binding site [chemical binding]; other site 1286640011293 Switch I region; other site 1286640011294 G2 box; other site 1286640011295 Switch II region; other site 1286640011296 G3 box; other site 1286640011297 G4 box; other site 1286640011298 G5 box; other site 1286640011299 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1286640011300 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1286640011301 putative active site [active] 1286640011302 putative catalytic site [active] 1286640011303 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1286640011304 putative active site [active] 1286640011305 putative catalytic site [active] 1286640011306 Domain of unknown function (DUF1873); Region: DUF1873; pfam08969 1286640011307 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286640011308 active site 1286640011309 Predicted small metal-binding protein [Function unknown]; Region: COG5466 1286640011310 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1286640011311 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1286640011312 active site 1286640011313 NTP binding site [chemical binding]; other site 1286640011314 metal binding triad [ion binding]; metal-binding site 1286640011315 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1286640011316 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1286640011317 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1286640011318 putative active site [active] 1286640011319 putative CoA binding site [chemical binding]; other site 1286640011320 nudix motif; other site 1286640011321 metal binding site [ion binding]; metal-binding site 1286640011322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 1286640011323 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1286640011324 MoxR-like ATPases [General function prediction only]; Region: COG0714 1286640011325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640011326 Walker A motif; other site 1286640011327 ATP binding site [chemical binding]; other site 1286640011328 Walker B motif; other site 1286640011329 arginine finger; other site 1286640011330 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1286640011331 Protein of unknown function DUF58; Region: DUF58; pfam01882 1286640011332 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 1286640011333 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1286640011334 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 1286640011335 CARDB; Region: CARDB; pfam07705 1286640011336 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1286640011337 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286640011338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640011339 Coenzyme A binding pocket [chemical binding]; other site 1286640011340 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1286640011341 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1286640011342 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1286640011343 putative dimer interface [polypeptide binding]; other site 1286640011344 N-terminal domain interface [polypeptide binding]; other site 1286640011345 putative substrate binding pocket (H-site) [chemical binding]; other site 1286640011346 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1286640011347 FIC domain binding interface [polypeptide binding]; other site 1286640011348 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1286640011349 Fic/DOC family; Region: Fic; cl00960 1286640011350 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 1286640011351 nudix motif; other site 1286640011352 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286640011353 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1286640011354 putative active site [active] 1286640011355 putative metal binding site [ion binding]; other site 1286640011356 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1286640011357 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1286640011358 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286640011359 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640011360 DNA binding residues [nucleotide binding] 1286640011361 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1286640011362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 1286640011363 putative active site [active] 1286640011364 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1286640011365 2-isopropylmalate synthase; Validated; Region: PRK03739 1286640011366 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1286640011367 active site 1286640011368 catalytic residues [active] 1286640011369 metal binding site [ion binding]; metal-binding site 1286640011370 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1286640011371 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1286640011372 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1286640011373 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286640011374 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1286640011375 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1286640011376 oligomer interface [polypeptide binding]; other site 1286640011377 active site residues [active] 1286640011378 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1286640011379 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1286640011380 Aminoglycoside phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: Aph; COG3231 1286640011381 Phosphotransferase enzyme family; Region: APH; pfam01636 1286640011382 active site 1286640011383 substrate binding site [chemical binding]; other site 1286640011384 ATP binding site [chemical binding]; other site 1286640011385 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1286640011386 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1286640011387 Cation efflux family; Region: Cation_efflux; cl00316 1286640011388 anthranilate synthase; Provisional; Region: PRK13566 1286640011389 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1286640011390 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1286640011391 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1286640011392 glutamine binding [chemical binding]; other site 1286640011393 catalytic triad [active] 1286640011394 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1286640011395 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1286640011396 N-terminal plug; other site 1286640011397 ligand-binding site [chemical binding]; other site 1286640011398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 1286640011399 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1286640011400 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1286640011401 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1286640011402 Potassium binding sites [ion binding]; other site 1286640011403 Cesium cation binding sites [ion binding]; other site 1286640011404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 1286640011405 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1286640011406 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1286640011407 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286640011408 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1286640011409 putative active site [active] 1286640011410 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1286640011411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1286640011412 thymidine kinase; Provisional; Region: PRK04296 1286640011413 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286640011414 ATP binding site [chemical binding]; other site 1286640011415 Walker A motif; other site 1286640011416 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1286640011417 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1286640011418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011419 dimer interface [polypeptide binding]; other site 1286640011420 conserved gate region; other site 1286640011421 putative PBP binding loops; other site 1286640011422 ABC-ATPase subunit interface; other site 1286640011423 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1286640011424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640011425 Walker A/P-loop; other site 1286640011426 ATP binding site [chemical binding]; other site 1286640011427 Q-loop/lid; other site 1286640011428 ABC transporter signature motif; other site 1286640011429 Walker B; other site 1286640011430 D-loop; other site 1286640011431 H-loop/switch region; other site 1286640011432 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1286640011433 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1286640011434 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1286640011435 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1286640011436 AAA domain; Region: AAA_33; pfam13671 1286640011437 AAA domain; Region: AAA_17; pfam13207 1286640011438 omega amino acid--pyruvate transaminase; Provisional; Region: PRK13360 1286640011439 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640011440 inhibitor-cofactor binding pocket; inhibition site 1286640011441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640011442 catalytic residue [active] 1286640011443 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1286640011444 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286640011445 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1286640011446 active site 1286640011447 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1286640011448 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 1286640011449 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1286640011450 active site 1286640011451 catalytic site [active] 1286640011452 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286640011453 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1286640011454 substrate binding site [chemical binding]; other site 1286640011455 ATP binding site [chemical binding]; other site 1286640011456 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1286640011457 MULE transposase domain; Region: MULE; pfam10551 1286640011458 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1286640011459 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640011460 Walker A/P-loop; other site 1286640011461 ATP binding site [chemical binding]; other site 1286640011462 Q-loop/lid; other site 1286640011463 ABC transporter signature motif; other site 1286640011464 Walker B; other site 1286640011465 D-loop; other site 1286640011466 H-loop/switch region; other site 1286640011467 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1286640011468 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640011469 Walker A/P-loop; other site 1286640011470 ATP binding site [chemical binding]; other site 1286640011471 Q-loop/lid; other site 1286640011472 ABC transporter signature motif; other site 1286640011473 Walker B; other site 1286640011474 D-loop; other site 1286640011475 H-loop/switch region; other site 1286640011476 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640011477 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286640011478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011479 ABC-ATPase subunit interface; other site 1286640011480 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640011481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011482 dimer interface [polypeptide binding]; other site 1286640011483 conserved gate region; other site 1286640011484 putative PBP binding loops; other site 1286640011485 ABC-ATPase subunit interface; other site 1286640011486 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640011487 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1286640011488 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1286640011489 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1286640011490 active site 1286640011491 dimer interface [polypeptide binding]; other site 1286640011492 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1286640011493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640011494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640011495 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1286640011496 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1286640011497 oligomeric interface; other site 1286640011498 putative active site [active] 1286640011499 homodimer interface [polypeptide binding]; other site 1286640011500 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1286640011501 apolar tunnel; other site 1286640011502 heme binding site [chemical binding]; other site 1286640011503 dimerization interface [polypeptide binding]; other site 1286640011504 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1286640011505 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1286640011506 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1286640011507 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1286640011508 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1286640011509 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1286640011510 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 1286640011511 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1286640011512 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1286640011513 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1286640011514 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1286640011515 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1286640011516 putative hemin binding site; other site 1286640011517 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286640011518 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286640011519 ABC-ATPase subunit interface; other site 1286640011520 dimer interface [polypeptide binding]; other site 1286640011521 putative PBP binding regions; other site 1286640011522 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1286640011523 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286640011524 Walker A/P-loop; other site 1286640011525 ATP binding site [chemical binding]; other site 1286640011526 Q-loop/lid; other site 1286640011527 ABC transporter signature motif; other site 1286640011528 Walker B; other site 1286640011529 D-loop; other site 1286640011530 H-loop/switch region; other site 1286640011531 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1286640011532 GAF domain; Region: GAF; pfam01590 1286640011533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640011534 PAS fold; Region: PAS_3; pfam08447 1286640011535 putative active site [active] 1286640011536 heme pocket [chemical binding]; other site 1286640011537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1286640011538 HWE histidine kinase; Region: HWE_HK; pfam07536 1286640011539 RNA polymerase sigma factor; Provisional; Region: PRK12516 1286640011540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286640011541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640011542 DNA binding residues [nucleotide binding] 1286640011543 two-component response regulator; Provisional; Region: PRK09191 1286640011544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640011545 active site 1286640011546 phosphorylation site [posttranslational modification] 1286640011547 intermolecular recognition site; other site 1286640011548 dimerization interface [polypeptide binding]; other site 1286640011549 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1286640011550 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 1286640011551 N- and C-terminal domain interface [polypeptide binding]; other site 1286640011552 active site 1286640011553 MgATP binding site [chemical binding]; other site 1286640011554 catalytic site [active] 1286640011555 metal binding site [ion binding]; metal-binding site 1286640011556 carbohydrate binding site [chemical binding]; other site 1286640011557 putative homodimer interface [polypeptide binding]; other site 1286640011558 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1286640011559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640011560 motif II; other site 1286640011561 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1286640011562 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1286640011563 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1286640011564 sorbitol dehydrogenase; Provisional; Region: PRK07067 1286640011565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640011566 NAD(P) binding site [chemical binding]; other site 1286640011567 active site 1286640011568 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286640011569 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640011570 Walker A/P-loop; other site 1286640011571 ATP binding site [chemical binding]; other site 1286640011572 Q-loop/lid; other site 1286640011573 ABC transporter signature motif; other site 1286640011574 Walker B; other site 1286640011575 D-loop; other site 1286640011576 H-loop/switch region; other site 1286640011577 TOBE domain; Region: TOBE_2; pfam08402 1286640011578 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640011579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011580 dimer interface [polypeptide binding]; other site 1286640011581 conserved gate region; other site 1286640011582 putative PBP binding loops; other site 1286640011583 ABC-ATPase subunit interface; other site 1286640011584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011585 dimer interface [polypeptide binding]; other site 1286640011586 conserved gate region; other site 1286640011587 putative PBP binding loops; other site 1286640011588 ABC-ATPase subunit interface; other site 1286640011589 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640011590 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640011591 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286640011592 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286640011593 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1286640011594 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286640011595 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1286640011596 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1286640011597 homodimer interface [polypeptide binding]; other site 1286640011598 active site 1286640011599 FMN binding site [chemical binding]; other site 1286640011600 substrate binding site [chemical binding]; other site 1286640011601 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1286640011602 4Fe-4S binding domain; Region: Fer4; pfam00037 1286640011603 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1286640011604 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286640011605 putative NAD(P) binding site [chemical binding]; other site 1286640011606 LysR family transcriptional regulator; Provisional; Region: PRK14997 1286640011607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640011608 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1286640011609 putative effector binding pocket; other site 1286640011610 putative dimerization interface [polypeptide binding]; other site 1286640011611 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1286640011612 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640011613 catalytic loop [active] 1286640011614 iron binding site [ion binding]; other site 1286640011615 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640011616 cyclase homology domain; Region: CHD; cd07302 1286640011617 nucleotidyl binding site; other site 1286640011618 metal binding site [ion binding]; metal-binding site 1286640011619 dimer interface [polypeptide binding]; other site 1286640011620 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1286640011621 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640011622 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1286640011623 allantoate amidohydrolase; Reviewed; Region: PRK12893 1286640011624 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1286640011625 active site 1286640011626 metal binding site [ion binding]; metal-binding site 1286640011627 dimer interface [polypeptide binding]; other site 1286640011628 phenylhydantoinase; Validated; Region: PRK08323 1286640011629 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1286640011630 tetramer interface [polypeptide binding]; other site 1286640011631 active site 1286640011632 Predicted mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: COG4101 1286640011633 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1286640011634 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286640011635 Walker A/P-loop; other site 1286640011636 ATP binding site [chemical binding]; other site 1286640011637 Q-loop/lid; other site 1286640011638 ABC transporter signature motif; other site 1286640011639 Walker B; other site 1286640011640 D-loop; other site 1286640011641 H-loop/switch region; other site 1286640011642 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286640011643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640011644 Coenzyme A binding pocket [chemical binding]; other site 1286640011645 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286640011646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011647 dimer interface [polypeptide binding]; other site 1286640011648 conserved gate region; other site 1286640011649 putative PBP binding loops; other site 1286640011650 ABC-ATPase subunit interface; other site 1286640011651 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286640011652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011653 dimer interface [polypeptide binding]; other site 1286640011654 conserved gate region; other site 1286640011655 putative PBP binding loops; other site 1286640011656 ABC-ATPase subunit interface; other site 1286640011657 NMT1/THI5 like; Region: NMT1; pfam09084 1286640011658 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286640011659 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640011660 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640011661 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1286640011662 Protein export membrane protein; Region: SecD_SecF; cl14618 1286640011663 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1286640011664 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1286640011665 UreF; Region: UreF; pfam01730 1286640011666 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 1286640011667 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1286640011668 dimer interface [polypeptide binding]; other site 1286640011669 catalytic residues [active] 1286640011670 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1286640011671 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1286640011672 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1286640011673 catalytic triad [active] 1286640011674 dimer interface [polypeptide binding]; other site 1286640011675 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 1286640011676 Predicted transcriptional regulator [Transcription]; Region: COG2944 1286640011677 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1286640011678 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1286640011679 subunit interactions [polypeptide binding]; other site 1286640011680 active site 1286640011681 flap region; other site 1286640011682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1286640011683 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1286640011684 alpha-beta subunit interface [polypeptide binding]; other site 1286640011685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1286640011686 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1286640011687 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1286640011688 alpha-gamma subunit interface [polypeptide binding]; other site 1286640011689 beta-gamma subunit interface [polypeptide binding]; other site 1286640011690 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1286640011691 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1286640011692 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1286640011693 dimerization interface [polypeptide binding]; other site 1286640011694 ligand binding site [chemical binding]; other site 1286640011695 NADP binding site [chemical binding]; other site 1286640011696 catalytic site [active] 1286640011697 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286640011698 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286640011699 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286640011700 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286640011701 MarR family; Region: MarR; pfam01047 1286640011702 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1286640011703 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1286640011704 dimerization interface [polypeptide binding]; other site 1286640011705 ligand binding site [chemical binding]; other site 1286640011706 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1286640011707 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1286640011708 Walker A/P-loop; other site 1286640011709 ATP binding site [chemical binding]; other site 1286640011710 Q-loop/lid; other site 1286640011711 ABC transporter signature motif; other site 1286640011712 Walker B; other site 1286640011713 D-loop; other site 1286640011714 H-loop/switch region; other site 1286640011715 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1286640011716 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1286640011717 Walker A/P-loop; other site 1286640011718 ATP binding site [chemical binding]; other site 1286640011719 Q-loop/lid; other site 1286640011720 ABC transporter signature motif; other site 1286640011721 Walker B; other site 1286640011722 D-loop; other site 1286640011723 H-loop/switch region; other site 1286640011724 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1286640011725 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1286640011726 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1286640011727 TM-ABC transporter signature motif; other site 1286640011728 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640011729 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1286640011730 TM-ABC transporter signature motif; other site 1286640011731 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1286640011732 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1286640011733 active site 1286640011734 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1286640011735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1286640011736 active site 1286640011737 phosphorylation site [posttranslational modification] 1286640011738 intermolecular recognition site; other site 1286640011739 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286640011740 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286640011741 ligand binding site [chemical binding]; other site 1286640011742 flexible hinge region; other site 1286640011743 putative switch regulator; other site 1286640011744 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1286640011745 non-specific DNA interactions [nucleotide binding]; other site 1286640011746 DNA binding site [nucleotide binding] 1286640011747 sequence specific DNA binding site [nucleotide binding]; other site 1286640011748 putative cAMP binding site [chemical binding]; other site 1286640011749 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1286640011750 classical (c) SDRs; Region: SDR_c; cd05233 1286640011751 NAD(P) binding site [chemical binding]; other site 1286640011752 active site 1286640011753 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1286640011754 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640011755 Zn binding site [ion binding]; other site 1286640011756 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1286640011757 Zn binding site [ion binding]; other site 1286640011758 Predicted esterase [General function prediction only]; Region: COG0400 1286640011759 putative hydrolase; Provisional; Region: PRK11460 1286640011760 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 1286640011761 HTH-like domain; Region: HTH_21; pfam13276 1286640011762 Integrase core domain; Region: rve; pfam00665 1286640011763 Integrase core domain; Region: rve_3; pfam13683 1286640011764 Transposase; Region: HTH_Tnp_1; cl17663 1286640011765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286640011766 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286640011767 Predicted flavoprotein [General function prediction only]; Region: COG0431 1286640011768 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1286640011769 Zn binding site [ion binding]; other site 1286640011770 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1286640011771 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640011772 Zn binding site [ion binding]; other site 1286640011773 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1286640011774 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1286640011775 putative active site [active] 1286640011776 catalytic triad [active] 1286640011777 putative dimer interface [polypeptide binding]; other site 1286640011778 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640011779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011780 dimer interface [polypeptide binding]; other site 1286640011781 conserved gate region; other site 1286640011782 putative PBP binding loops; other site 1286640011783 ABC-ATPase subunit interface; other site 1286640011784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011785 putative PBP binding loops; other site 1286640011786 ABC-ATPase subunit interface; other site 1286640011787 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286640011788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640011789 Walker A/P-loop; other site 1286640011790 ATP binding site [chemical binding]; other site 1286640011791 Q-loop/lid; other site 1286640011792 ABC transporter signature motif; other site 1286640011793 Walker B; other site 1286640011794 D-loop; other site 1286640011795 H-loop/switch region; other site 1286640011796 TOBE domain; Region: TOBE_2; pfam08402 1286640011797 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1286640011798 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286640011799 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1286640011800 agmatinase; Region: agmatinase; TIGR01230 1286640011801 oligomer interface [polypeptide binding]; other site 1286640011802 putative active site [active] 1286640011803 Mn binding site [ion binding]; other site 1286640011804 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286640011805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640011806 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1286640011807 dimerization interface [polypeptide binding]; other site 1286640011808 substrate binding pocket [chemical binding]; other site 1286640011809 hypothetical protein; Provisional; Region: PRK07550 1286640011810 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640011811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640011812 homodimer interface [polypeptide binding]; other site 1286640011813 catalytic residue [active] 1286640011814 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1286640011815 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286640011816 NAD binding site [chemical binding]; other site 1286640011817 catalytic residues [active] 1286640011818 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286640011819 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640011820 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1286640011821 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1286640011822 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640011823 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640011824 DNA-binding site [nucleotide binding]; DNA binding site 1286640011825 FCD domain; Region: FCD; pfam07729 1286640011826 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640011827 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640011828 DNA-binding site [nucleotide binding]; DNA binding site 1286640011829 FCD domain; Region: FCD; pfam07729 1286640011830 hypothetical protein; Provisional; Region: PRK05968 1286640011831 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286640011832 homodimer interface [polypeptide binding]; other site 1286640011833 substrate-cofactor binding pocket; other site 1286640011834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640011835 catalytic residue [active] 1286640011836 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640011837 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640011838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011839 dimer interface [polypeptide binding]; other site 1286640011840 conserved gate region; other site 1286640011841 putative PBP binding loops; other site 1286640011842 ABC-ATPase subunit interface; other site 1286640011843 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640011844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011845 dimer interface [polypeptide binding]; other site 1286640011846 conserved gate region; other site 1286640011847 putative PBP binding loops; other site 1286640011848 ABC-ATPase subunit interface; other site 1286640011849 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640011850 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640011851 Walker A/P-loop; other site 1286640011852 ATP binding site [chemical binding]; other site 1286640011853 Q-loop/lid; other site 1286640011854 ABC transporter signature motif; other site 1286640011855 Walker B; other site 1286640011856 D-loop; other site 1286640011857 H-loop/switch region; other site 1286640011858 TOBE domain; Region: TOBE_2; pfam08402 1286640011859 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1286640011860 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 1286640011861 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1286640011862 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1286640011863 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1286640011864 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1286640011865 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 1286640011866 Subunit I/III interface [polypeptide binding]; other site 1286640011867 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 1286640011868 Subunit I/III interface [polypeptide binding]; other site 1286640011869 Predicted small integral membrane protein [Function unknown]; Region: COG5605 1286640011870 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640011871 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640011872 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1286640011873 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1286640011874 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286640011875 active site 1286640011876 metal binding site [ion binding]; metal-binding site 1286640011877 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640011878 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1286640011879 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640011880 short chain dehydrogenase; Provisional; Region: PRK07060 1286640011881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640011882 NAD(P) binding site [chemical binding]; other site 1286640011883 active site 1286640011884 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286640011885 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1286640011886 inhibitor binding site; inhibition site 1286640011887 catalytic Zn binding site [ion binding]; other site 1286640011888 structural Zn binding site [ion binding]; other site 1286640011889 NADP binding site [chemical binding]; other site 1286640011890 tetramer interface [polypeptide binding]; other site 1286640011891 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1286640011892 [2Fe-2S] cluster binding site [ion binding]; other site 1286640011893 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1286640011894 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640011895 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1286640011896 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1286640011897 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640011898 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640011899 TM-ABC transporter signature motif; other site 1286640011900 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1286640011901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640011902 Walker A/P-loop; other site 1286640011903 ATP binding site [chemical binding]; other site 1286640011904 Q-loop/lid; other site 1286640011905 ABC transporter signature motif; other site 1286640011906 Walker B; other site 1286640011907 D-loop; other site 1286640011908 H-loop/switch region; other site 1286640011909 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1286640011910 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286640011911 putative ligand binding site [chemical binding]; other site 1286640011912 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640011913 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640011914 DNA binding site [nucleotide binding] 1286640011915 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1286640011916 putative ligand binding site [chemical binding]; other site 1286640011917 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1286640011918 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 1286640011919 putative metal binding site [ion binding]; other site 1286640011920 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640011921 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1286640011922 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1286640011923 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1286640011924 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1286640011925 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640011926 Walker A/P-loop; other site 1286640011927 ATP binding site [chemical binding]; other site 1286640011928 Q-loop/lid; other site 1286640011929 ABC transporter signature motif; other site 1286640011930 Walker B; other site 1286640011931 D-loop; other site 1286640011932 H-loop/switch region; other site 1286640011933 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640011934 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640011935 Walker A/P-loop; other site 1286640011936 ATP binding site [chemical binding]; other site 1286640011937 Q-loop/lid; other site 1286640011938 ABC transporter signature motif; other site 1286640011939 Walker B; other site 1286640011940 D-loop; other site 1286640011941 H-loop/switch region; other site 1286640011942 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640011943 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1286640011944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640011945 dimer interface [polypeptide binding]; other site 1286640011946 conserved gate region; other site 1286640011947 putative PBP binding loops; other site 1286640011948 ABC-ATPase subunit interface; other site 1286640011949 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640011950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286640011951 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640011952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640011953 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1286640011954 putative dimerization interface [polypeptide binding]; other site 1286640011955 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640011956 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640011957 TM-ABC transporter signature motif; other site 1286640011958 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640011959 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640011960 Walker A/P-loop; other site 1286640011961 ATP binding site [chemical binding]; other site 1286640011962 Q-loop/lid; other site 1286640011963 ABC transporter signature motif; other site 1286640011964 Walker B; other site 1286640011965 D-loop; other site 1286640011966 H-loop/switch region; other site 1286640011967 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640011968 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640011969 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1286640011970 ligand binding site [chemical binding]; other site 1286640011971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640011972 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640011973 NAD(P) binding site [chemical binding]; other site 1286640011974 active site 1286640011975 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1286640011976 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640011977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640011978 DNA-binding site [nucleotide binding]; DNA binding site 1286640011979 FCD domain; Region: FCD; pfam07729 1286640011980 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640011981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640011982 NAD(P) binding site [chemical binding]; other site 1286640011983 active site 1286640011984 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1286640011985 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1286640011986 dimer interface [polypeptide binding]; other site 1286640011987 active site 1286640011988 metal binding site [ion binding]; metal-binding site 1286640011989 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1286640011990 classical (c) SDRs; Region: SDR_c; cd05233 1286640011991 NAD(P) binding site [chemical binding]; other site 1286640011992 active site 1286640011993 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1286640011994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640011995 active site 1286640011996 short chain dehydrogenase; Provisional; Region: PRK06841 1286640011997 classical (c) SDRs; Region: SDR_c; cd05233 1286640011998 NAD(P) binding site [chemical binding]; other site 1286640011999 active site 1286640012000 glucose-6-phosphate isomerase; Provisional; Region: PRK04190 1286640012001 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 1286640012002 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1286640012003 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1286640012004 active site 1286640012005 intersubunit interface [polypeptide binding]; other site 1286640012006 catalytic residue [active] 1286640012007 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1286640012008 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1286640012009 NAD(P) binding pocket [chemical binding]; other site 1286640012010 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 1286640012011 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1286640012012 putative ligand binding site [chemical binding]; other site 1286640012013 putative NAD binding site [chemical binding]; other site 1286640012014 catalytic site [active] 1286640012015 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1286640012016 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1286640012017 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1286640012018 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286640012019 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286640012020 putative active site [active] 1286640012021 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1286640012022 intersubunit interface [polypeptide binding]; other site 1286640012023 active site 1286640012024 catalytic residue [active] 1286640012025 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1286640012026 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 1286640012027 N- and C-terminal domain interface [polypeptide binding]; other site 1286640012028 active site 1286640012029 MgATP binding site [chemical binding]; other site 1286640012030 catalytic site [active] 1286640012031 metal binding site [ion binding]; metal-binding site 1286640012032 xylulose binding site [chemical binding]; other site 1286640012033 putative homodimer interface [polypeptide binding]; other site 1286640012034 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1286640012035 D-xylulose kinases, subgroup 3; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_3; cd07811 1286640012036 putative N- and C-terminal domain interface [polypeptide binding]; other site 1286640012037 putative active site [active] 1286640012038 putative MgATP binding site [chemical binding]; other site 1286640012039 catalytic site [active] 1286640012040 metal binding site [ion binding]; metal-binding site 1286640012041 putative xylulose binding site [chemical binding]; other site 1286640012042 putative homodimer interface [polypeptide binding]; other site 1286640012043 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1286640012044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640012045 NAD(P) binding site [chemical binding]; other site 1286640012046 active site 1286640012047 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640012048 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640012049 TM-ABC transporter signature motif; other site 1286640012050 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640012051 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640012052 Walker A/P-loop; other site 1286640012053 ATP binding site [chemical binding]; other site 1286640012054 Q-loop/lid; other site 1286640012055 ABC transporter signature motif; other site 1286640012056 Walker B; other site 1286640012057 D-loop; other site 1286640012058 H-loop/switch region; other site 1286640012059 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640012060 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640012061 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 1286640012062 putative ligand binding site [chemical binding]; other site 1286640012063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640012064 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640012065 NAD(P) binding site [chemical binding]; other site 1286640012066 active site 1286640012067 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1286640012068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640012069 DNA-binding site [nucleotide binding]; DNA binding site 1286640012070 UTRA domain; Region: UTRA; pfam07702 1286640012071 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1286640012072 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1286640012073 N- and C-terminal domain interface [polypeptide binding]; other site 1286640012074 active site 1286640012075 MgATP binding site [chemical binding]; other site 1286640012076 catalytic site [active] 1286640012077 metal binding site [ion binding]; metal-binding site 1286640012078 xylulose binding site [chemical binding]; other site 1286640012079 homodimer interface [polypeptide binding]; other site 1286640012080 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1286640012081 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1286640012082 TPP-binding site [chemical binding]; other site 1286640012083 dimer interface [polypeptide binding]; other site 1286640012084 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1286640012085 PYR/PP interface [polypeptide binding]; other site 1286640012086 dimer interface [polypeptide binding]; other site 1286640012087 TPP binding site [chemical binding]; other site 1286640012088 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286640012089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640012090 putative transporter; Provisional; Region: PRK10504 1286640012091 putative substrate translocation pore; other site 1286640012092 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1286640012093 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640012094 substrate binding pocket [chemical binding]; other site 1286640012095 membrane-bound complex binding site; other site 1286640012096 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286640012097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640012098 dimer interface [polypeptide binding]; other site 1286640012099 conserved gate region; other site 1286640012100 putative PBP binding loops; other site 1286640012101 ABC-ATPase subunit interface; other site 1286640012102 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1286640012103 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286640012104 Walker A/P-loop; other site 1286640012105 ATP binding site [chemical binding]; other site 1286640012106 Q-loop/lid; other site 1286640012107 ABC transporter signature motif; other site 1286640012108 Walker B; other site 1286640012109 D-loop; other site 1286640012110 H-loop/switch region; other site 1286640012111 Ferredoxin [Energy production and conversion]; Region: COG1146 1286640012112 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1286640012113 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1286640012114 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1286640012115 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1286640012116 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286640012117 putative catalytic residue [active] 1286640012118 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1286640012119 apolar tunnel; other site 1286640012120 heme binding site [chemical binding]; other site 1286640012121 dimerization interface [polypeptide binding]; other site 1286640012122 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1286640012123 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1286640012124 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286640012125 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286640012126 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286640012127 putative active site [active] 1286640012128 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 1286640012129 Isochorismatase family; Region: Isochorismatase; pfam00857 1286640012130 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1286640012131 catalytic triad [active] 1286640012132 conserved cis-peptide bond; other site 1286640012133 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1286640012134 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1286640012135 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1286640012136 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1286640012137 Walker A/P-loop; other site 1286640012138 ATP binding site [chemical binding]; other site 1286640012139 Q-loop/lid; other site 1286640012140 ABC transporter signature motif; other site 1286640012141 Walker B; other site 1286640012142 D-loop; other site 1286640012143 H-loop/switch region; other site 1286640012144 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1286640012145 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1286640012146 Walker A/P-loop; other site 1286640012147 ATP binding site [chemical binding]; other site 1286640012148 Q-loop/lid; other site 1286640012149 ABC transporter signature motif; other site 1286640012150 Walker B; other site 1286640012151 D-loop; other site 1286640012152 H-loop/switch region; other site 1286640012153 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1286640012154 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640012155 TM-ABC transporter signature motif; other site 1286640012156 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1286640012157 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1286640012158 TM-ABC transporter signature motif; other site 1286640012159 Isochorismatase family; Region: Isochorismatase; pfam00857 1286640012160 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1286640012161 catalytic triad [active] 1286640012162 conserved cis-peptide bond; other site 1286640012163 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1286640012164 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640012165 inhibitor-cofactor binding pocket; inhibition site 1286640012166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640012167 catalytic residue [active] 1286640012168 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1286640012169 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286640012170 active site 1286640012171 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1286640012172 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640012173 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 1286640012174 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286640012175 active site 1286640012176 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640012177 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1286640012178 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640012179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640012180 dimer interface [polypeptide binding]; other site 1286640012181 conserved gate region; other site 1286640012182 putative PBP binding loops; other site 1286640012183 ABC-ATPase subunit interface; other site 1286640012184 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1286640012185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640012186 dimer interface [polypeptide binding]; other site 1286640012187 conserved gate region; other site 1286640012188 putative PBP binding loops; other site 1286640012189 ABC-ATPase subunit interface; other site 1286640012190 cytosine deaminase; Provisional; Region: PRK05985 1286640012191 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1286640012192 active site 1286640012193 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 1286640012194 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286640012195 active site 1286640012196 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286640012197 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640012198 Walker A/P-loop; other site 1286640012199 ATP binding site [chemical binding]; other site 1286640012200 Q-loop/lid; other site 1286640012201 ABC transporter signature motif; other site 1286640012202 Walker B; other site 1286640012203 D-loop; other site 1286640012204 H-loop/switch region; other site 1286640012205 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640012206 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1286640012207 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640012208 Walker A/P-loop; other site 1286640012209 ATP binding site [chemical binding]; other site 1286640012210 Q-loop/lid; other site 1286640012211 ABC transporter signature motif; other site 1286640012212 Walker B; other site 1286640012213 D-loop; other site 1286640012214 H-loop/switch region; other site 1286640012215 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286640012216 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1286640012217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640012218 DNA-binding site [nucleotide binding]; DNA binding site 1286640012219 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286640012220 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1286640012221 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 1286640012222 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640012223 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286640012224 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1286640012225 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1286640012226 [2Fe-2S] cluster binding site [ion binding]; other site 1286640012227 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640012228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640012229 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1286640012230 putative effector binding pocket; other site 1286640012231 putative dimerization interface [polypeptide binding]; other site 1286640012232 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1286640012233 Transposase domain (DUF772); Region: DUF772; pfam05598 1286640012234 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1286640012235 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1286640012236 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286640012237 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286640012238 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1286640012239 Clp amino terminal domain; Region: Clp_N; pfam02861 1286640012240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640012241 Walker A motif; other site 1286640012242 ATP binding site [chemical binding]; other site 1286640012243 Walker B motif; other site 1286640012244 arginine finger; other site 1286640012245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640012246 Walker A motif; other site 1286640012247 ATP binding site [chemical binding]; other site 1286640012248 Walker B motif; other site 1286640012249 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1286640012250 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 1286640012251 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1286640012252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640012253 S-adenosylmethionine binding site [chemical binding]; other site 1286640012254 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1286640012255 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1286640012256 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1286640012257 RF-1 domain; Region: RF-1; pfam00472 1286640012258 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1286640012259 GAF domain; Region: GAF; pfam01590 1286640012260 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1286640012261 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1286640012262 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1286640012263 aspartate kinase; Reviewed; Region: PRK06635 1286640012264 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1286640012265 putative nucleotide binding site [chemical binding]; other site 1286640012266 putative catalytic residues [active] 1286640012267 putative Mg ion binding site [ion binding]; other site 1286640012268 putative aspartate binding site [chemical binding]; other site 1286640012269 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1286640012270 putative allosteric regulatory site; other site 1286640012271 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1286640012272 RibD C-terminal domain; Region: RibD_C; cl17279 1286640012273 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1286640012274 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1286640012275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640012276 S-adenosylmethionine binding site [chemical binding]; other site 1286640012277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 1286640012278 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1286640012279 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1286640012280 putative active site [active] 1286640012281 catalytic triad [active] 1286640012282 dimer interface [polypeptide binding]; other site 1286640012283 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1286640012284 GSH binding site [chemical binding]; other site 1286640012285 catalytic residues [active] 1286640012286 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1286640012287 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1286640012288 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1286640012289 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1286640012290 active site 1286640012291 8-oxo-dGMP binding site [chemical binding]; other site 1286640012292 nudix motif; other site 1286640012293 metal binding site [ion binding]; metal-binding site 1286640012294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640012295 Coenzyme A binding pocket [chemical binding]; other site 1286640012296 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1286640012297 heterotetramer interface [polypeptide binding]; other site 1286640012298 active site pocket [active] 1286640012299 cleavage site 1286640012300 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1286640012301 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1286640012302 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1286640012303 SEC-C motif; Region: SEC-C; pfam02810 1286640012304 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1286640012305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640012306 putative substrate translocation pore; other site 1286640012307 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1286640012308 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1286640012309 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1286640012310 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1286640012311 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 1286640012312 active site 1286640012313 acyl-activating enzyme (AAE) consensus motif; other site 1286640012314 putative CoA binding site [chemical binding]; other site 1286640012315 AMP binding site [chemical binding]; other site 1286640012316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1286640012317 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1286640012318 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640012319 Coenzyme A binding pocket [chemical binding]; other site 1286640012320 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 1286640012321 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1286640012322 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286640012323 active site 1286640012324 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1286640012325 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1286640012326 minor groove reading motif; other site 1286640012327 helix-hairpin-helix signature motif; other site 1286640012328 substrate binding pocket [chemical binding]; other site 1286640012329 active site 1286640012330 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1286640012331 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1286640012332 active site 1286640012333 HIGH motif; other site 1286640012334 nucleotide binding site [chemical binding]; other site 1286640012335 active site 1286640012336 KMSKS motif; other site 1286640012337 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1286640012338 short chain dehydrogenase; Provisional; Region: PRK05993 1286640012339 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1286640012340 NADP binding site [chemical binding]; other site 1286640012341 active site 1286640012342 steroid binding site; other site 1286640012343 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 1286640012344 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1286640012345 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1286640012346 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1286640012347 Ligand binding site [chemical binding]; other site 1286640012348 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1286640012349 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1286640012350 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1286640012351 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1286640012352 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 1286640012353 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1286640012354 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286640012355 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1286640012356 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286640012357 catalytic residues [active] 1286640012358 argininosuccinate lyase; Provisional; Region: PRK00855 1286640012359 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1286640012360 active sites [active] 1286640012361 tetramer interface [polypeptide binding]; other site 1286640012362 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 1286640012363 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1286640012364 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1286640012365 active site 1286640012366 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286640012367 substrate binding site [chemical binding]; other site 1286640012368 catalytic residues [active] 1286640012369 dimer interface [polypeptide binding]; other site 1286640012370 TIGR02302 family protein; Region: aProt_lowcomp 1286640012371 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1286640012372 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1286640012373 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286640012374 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640012375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640012376 active site 1286640012377 phosphorylation site [posttranslational modification] 1286640012378 intermolecular recognition site; other site 1286640012379 dimerization interface [polypeptide binding]; other site 1286640012380 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286640012381 active site 1286640012382 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1286640012383 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286640012384 Walker A/P-loop; other site 1286640012385 ATP binding site [chemical binding]; other site 1286640012386 Q-loop/lid; other site 1286640012387 ABC transporter signature motif; other site 1286640012388 Walker B; other site 1286640012389 D-loop; other site 1286640012390 H-loop/switch region; other site 1286640012391 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1286640012392 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1286640012393 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1286640012394 putative active site [active] 1286640012395 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1286640012396 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1286640012397 putative acyl-acceptor binding pocket; other site 1286640012398 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1286640012399 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1286640012400 putative active site pocket [active] 1286640012401 dimerization interface [polypeptide binding]; other site 1286640012402 putative catalytic residue [active] 1286640012403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 1286640012404 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 1286640012405 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 1286640012406 prephenate dehydrogenase; Validated; Region: PRK08507 1286640012407 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1286640012408 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640012409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640012410 homodimer interface [polypeptide binding]; other site 1286640012411 catalytic residue [active] 1286640012412 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286640012413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640012414 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1286640012415 Uncharacterized conserved protein [Function unknown]; Region: COG3542 1286640012416 aromatic amino acid exporter; Provisional; Region: PRK11689 1286640012417 EamA-like transporter family; Region: EamA; pfam00892 1286640012418 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1286640012419 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1286640012420 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1286640012421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 1286640012422 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1286640012423 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 1286640012424 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 1286640012425 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1286640012426 metal ion-dependent adhesion site (MIDAS); other site 1286640012427 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 1286640012428 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 1286640012429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1286640012430 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 1286640012431 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1286640012432 HSP70 interaction site [polypeptide binding]; other site 1286640012433 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1286640012434 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1286640012435 Domain of unknown function DUF21; Region: DUF21; pfam01595 1286640012436 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1286640012437 Transporter associated domain; Region: CorC_HlyC; smart01091 1286640012438 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1286640012439 active site 1286640012440 dimer interface [polypeptide binding]; other site 1286640012441 metal binding site [ion binding]; metal-binding site 1286640012442 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1286640012443 AAA domain; Region: AAA_18; pfam13238 1286640012444 ADP binding site [chemical binding]; other site 1286640012445 magnesium binding site [ion binding]; other site 1286640012446 putative shikimate binding site; other site 1286640012447 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1286640012448 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1286640012449 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1286640012450 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286640012451 active site 1286640012452 DNA binding site [nucleotide binding] 1286640012453 Int/Topo IB signature motif; other site 1286640012454 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1286640012455 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1286640012456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1286640012457 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1286640012458 CPxP motif; other site 1286640012459 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1286640012460 oligomeric interface; other site 1286640012461 putative active site [active] 1286640012462 homodimer interface [polypeptide binding]; other site 1286640012463 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1286640012464 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1286640012465 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1286640012466 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1286640012467 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1286640012468 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286640012469 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1286640012470 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1286640012471 metal binding site [ion binding]; metal-binding site 1286640012472 putative dimer interface [polypeptide binding]; other site 1286640012473 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640012474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640012475 putative DNA binding site [nucleotide binding]; other site 1286640012476 putative Zn2+ binding site [ion binding]; other site 1286640012477 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640012478 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1286640012479 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1286640012480 putative NAD(P) binding site [chemical binding]; other site 1286640012481 putative substrate binding site [chemical binding]; other site 1286640012482 catalytic Zn binding site [ion binding]; other site 1286640012483 structural Zn binding site [ion binding]; other site 1286640012484 dimer interface [polypeptide binding]; other site 1286640012485 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1286640012486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640012487 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640012488 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640012489 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1286640012490 putative DNA binding site [nucleotide binding]; other site 1286640012491 putative Zn2+ binding site [ion binding]; other site 1286640012492 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640012493 hypothetical protein; Provisional; Region: PRK06148 1286640012494 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1286640012495 active site 1286640012496 ATP binding site [chemical binding]; other site 1286640012497 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286640012498 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640012499 inhibitor-cofactor binding pocket; inhibition site 1286640012500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640012501 catalytic residue [active] 1286640012502 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1286640012503 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640012504 substrate binding pocket [chemical binding]; other site 1286640012505 membrane-bound complex binding site; other site 1286640012506 hinge residues; other site 1286640012507 hypothetical protein; Provisional; Region: PRK06149 1286640012508 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1286640012509 active site 1286640012510 ATP binding site [chemical binding]; other site 1286640012511 substrate binding site [chemical binding]; other site 1286640012512 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640012513 inhibitor-cofactor binding pocket; inhibition site 1286640012514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640012515 catalytic residue [active] 1286640012516 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1286640012517 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640012518 DNA-binding site [nucleotide binding]; DNA binding site 1286640012519 UTRA domain; Region: UTRA; pfam07702 1286640012520 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1286640012521 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1286640012522 active site 1286640012523 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1286640012524 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1286640012525 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1286640012526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640012527 dimer interface [polypeptide binding]; other site 1286640012528 conserved gate region; other site 1286640012529 ABC-ATPase subunit interface; other site 1286640012530 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286640012531 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1286640012532 Walker A/P-loop; other site 1286640012533 ATP binding site [chemical binding]; other site 1286640012534 Q-loop/lid; other site 1286640012535 ABC transporter signature motif; other site 1286640012536 Walker B; other site 1286640012537 D-loop; other site 1286640012538 H-loop/switch region; other site 1286640012539 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1286640012540 active sites [active] 1286640012541 tetramer interface [polypeptide binding]; other site 1286640012542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1286640012543 Nucleoside recognition; Region: Gate; pfam07670 1286640012544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 1286640012545 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1286640012546 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1286640012547 Ligand Binding Site [chemical binding]; other site 1286640012548 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1286640012549 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640012550 DNA binding residues [nucleotide binding] 1286640012551 dimerization interface [polypeptide binding]; other site 1286640012552 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 1286640012553 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1286640012554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640012555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640012556 active site 1286640012557 phosphorylation site [posttranslational modification] 1286640012558 intermolecular recognition site; other site 1286640012559 dimerization interface [polypeptide binding]; other site 1286640012560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640012561 DNA binding site [nucleotide binding] 1286640012562 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640012563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640012564 active site 1286640012565 phosphorylation site [posttranslational modification] 1286640012566 intermolecular recognition site; other site 1286640012567 dimerization interface [polypeptide binding]; other site 1286640012568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 1286640012569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400 1286640012570 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1286640012571 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1286640012572 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1286640012573 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1286640012574 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286640012575 RNA binding surface [nucleotide binding]; other site 1286640012576 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1286640012577 active site 1286640012578 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1286640012579 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1286640012580 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286640012581 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640012582 DNA binding residues [nucleotide binding] 1286640012583 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1286640012584 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1286640012585 GDP-binding site [chemical binding]; other site 1286640012586 ACT binding site; other site 1286640012587 IMP binding site; other site 1286640012588 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286640012589 EamA-like transporter family; Region: EamA; pfam00892 1286640012590 EamA-like transporter family; Region: EamA; pfam00892 1286640012591 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1286640012592 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1286640012593 ligand binding site [chemical binding]; other site 1286640012594 NAD binding site [chemical binding]; other site 1286640012595 dimerization interface [polypeptide binding]; other site 1286640012596 catalytic site [active] 1286640012597 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1286640012598 putative L-serine binding site [chemical binding]; other site 1286640012599 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 1286640012600 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286640012601 catalytic residue [active] 1286640012602 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1286640012603 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1286640012604 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 1286640012605 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1286640012606 active site 1286640012607 substrate binding site [chemical binding]; other site 1286640012608 metal binding site [ion binding]; metal-binding site 1286640012609 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1286640012610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640012611 Walker A motif; other site 1286640012612 ATP binding site [chemical binding]; other site 1286640012613 Walker B motif; other site 1286640012614 arginine finger; other site 1286640012615 Peptidase family M41; Region: Peptidase_M41; pfam01434 1286640012616 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1286640012617 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1286640012618 Ligand Binding Site [chemical binding]; other site 1286640012619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640012620 binding surface 1286640012621 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1286640012622 TPR motif; other site 1286640012623 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1286640012624 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1286640012625 ligand binding site [chemical binding]; other site 1286640012626 translocation protein TolB; Provisional; Region: tolB; PRK05137 1286640012627 TolB amino-terminal domain; Region: TolB_N; pfam04052 1286640012628 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1286640012629 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1286640012630 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1286640012631 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1286640012632 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1286640012633 TolR protein; Region: tolR; TIGR02801 1286640012634 TolQ protein; Region: tolQ; TIGR02796 1286640012635 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 1286640012636 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1286640012637 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1286640012638 active site 1286640012639 DNA binding site [nucleotide binding] 1286640012640 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1286640012641 DNA binding site [nucleotide binding] 1286640012642 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1286640012643 nucleotide binding site [chemical binding]; other site 1286640012644 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1286640012645 active site 1286640012646 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 1286640012647 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640012648 NAD binding site [chemical binding]; other site 1286640012649 substrate binding site [chemical binding]; other site 1286640012650 active site 1286640012651 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 1286640012652 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1286640012653 substrate binding site; other site 1286640012654 Manganese binding site; other site 1286640012655 dimer interface; other site 1286640012656 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640012657 extended (e) SDRs; Region: SDR_e; cd08946 1286640012658 NAD(P) binding site [chemical binding]; other site 1286640012659 active site 1286640012660 substrate binding site [chemical binding]; other site 1286640012661 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1286640012662 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286640012663 putative active site [active] 1286640012664 putative metal binding site [ion binding]; other site 1286640012665 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1286640012666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640012667 Walker A motif; other site 1286640012668 ATP binding site [chemical binding]; other site 1286640012669 Walker B motif; other site 1286640012670 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1286640012671 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1286640012672 RuvA N terminal domain; Region: RuvA_N; pfam01330 1286640012673 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1286640012674 active site 1286640012675 putative DNA-binding cleft [nucleotide binding]; other site 1286640012676 dimer interface [polypeptide binding]; other site 1286640012677 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1286640012678 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1286640012679 hypothetical protein; Validated; Region: PRK00110 1286640012680 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1286640012681 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1286640012682 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1286640012683 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286640012684 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640012685 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640012686 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1286640012687 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286640012688 putative active site [active] 1286640012689 metal binding site [ion binding]; metal-binding site 1286640012690 homodimer binding site [polypeptide binding]; other site 1286640012691 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1286640012692 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1286640012693 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640012694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640012695 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1286640012696 dimerization interface [polypeptide binding]; other site 1286640012697 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 1286640012698 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 1286640012699 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1286640012700 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1286640012701 TPP-binding site [chemical binding]; other site 1286640012702 dimer interface [polypeptide binding]; other site 1286640012703 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1286640012704 PYR/PP interface [polypeptide binding]; other site 1286640012705 dimer interface [polypeptide binding]; other site 1286640012706 TPP binding site [chemical binding]; other site 1286640012707 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286640012708 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1286640012709 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1286640012710 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1286640012711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 1286640012712 Phosphoglycerate kinase; Region: PGK; pfam00162 1286640012713 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1286640012714 substrate binding site [chemical binding]; other site 1286640012715 hinge regions; other site 1286640012716 ADP binding site [chemical binding]; other site 1286640012717 catalytic site [active] 1286640012718 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1286640012719 MULE transposase domain; Region: MULE; pfam10551 1286640012720 Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: COG3588 1286640012721 catalytic residue [active] 1286640012722 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1286640012723 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640012724 cyclase homology domain; Region: CHD; cd07302 1286640012725 nucleotidyl binding site; other site 1286640012726 metal binding site [ion binding]; metal-binding site 1286640012727 dimer interface [polypeptide binding]; other site 1286640012728 Predicted integral membrane protein [Function unknown]; Region: COG5616 1286640012729 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286640012730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640012731 TPR motif; other site 1286640012732 TPR repeat; Region: TPR_11; pfam13414 1286640012733 binding surface 1286640012734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640012735 binding surface 1286640012736 TPR motif; other site 1286640012737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640012738 putative substrate translocation pore; other site 1286640012739 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 1286640012740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 1286640012741 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 1286640012742 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1286640012743 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640012744 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1286640012745 Walker A/P-loop; other site 1286640012746 ATP binding site [chemical binding]; other site 1286640012747 Q-loop/lid; other site 1286640012748 ABC transporter signature motif; other site 1286640012749 Walker B; other site 1286640012750 D-loop; other site 1286640012751 H-loop/switch region; other site 1286640012752 hypothetical protein; Validated; Region: PRK09039 1286640012753 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1286640012754 ligand binding site [chemical binding]; other site 1286640012755 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1286640012756 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1286640012757 active site 1286640012758 dimerization interface [polypeptide binding]; other site 1286640012759 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1286640012760 Sel1-like repeats; Region: SEL1; smart00671 1286640012761 Sel1-like repeats; Region: SEL1; smart00671 1286640012762 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1286640012763 thiamine phosphate binding site [chemical binding]; other site 1286640012764 active site 1286640012765 pyrophosphate binding site [ion binding]; other site 1286640012766 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286640012767 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640012768 dimerization interface [polypeptide binding]; other site 1286640012769 putative DNA binding site [nucleotide binding]; other site 1286640012770 putative Zn2+ binding site [ion binding]; other site 1286640012771 Uncharacterized small protein [Function unknown]; Region: COG5570 1286640012772 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 1286640012773 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1286640012774 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1286640012775 ATP-grasp domain; Region: ATP-grasp; pfam02222 1286640012776 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1286640012777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640012778 TPR repeat; Region: TPR_11; pfam13414 1286640012779 binding surface 1286640012780 TPR motif; other site 1286640012781 pyruvate kinase; Provisional; Region: PRK06247 1286640012782 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1286640012783 domain interfaces; other site 1286640012784 active site 1286640012785 Predicted integral membrane protein [Function unknown]; Region: COG5480 1286640012786 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 1286640012787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 1286640012788 hypothetical protein; Provisional; Region: PRK13694 1286640012789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1286640012790 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 1286640012791 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1286640012792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640012793 active site 1286640012794 phosphorylation site [posttranslational modification] 1286640012795 intermolecular recognition site; other site 1286640012796 dimerization interface [polypeptide binding]; other site 1286640012797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640012798 Walker A motif; other site 1286640012799 ATP binding site [chemical binding]; other site 1286640012800 Walker B motif; other site 1286640012801 arginine finger; other site 1286640012802 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286640012803 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1286640012804 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 1286640012805 active site 1286640012806 Zn binding site [ion binding]; other site 1286640012807 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1286640012808 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1286640012809 hypothetical protein; Provisional; Region: PRK07546 1286640012810 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1286640012811 substrate-cofactor binding pocket; other site 1286640012812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640012813 catalytic residue [active] 1286640012814 PAS fold; Region: PAS_7; pfam12860 1286640012815 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286640012816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640012817 metal binding site [ion binding]; metal-binding site 1286640012818 active site 1286640012819 I-site; other site 1286640012820 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 1286640012821 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1286640012822 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1286640012823 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 1286640012824 active site 1286640012825 metal binding site [ion binding]; metal-binding site 1286640012826 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1286640012827 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286640012828 ferrochelatase; Reviewed; Region: hemH; PRK00035 1286640012829 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1286640012830 C-terminal domain interface [polypeptide binding]; other site 1286640012831 active site 1286640012832 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1286640012833 active site 1286640012834 N-terminal domain interface [polypeptide binding]; other site 1286640012835 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1286640012836 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1286640012837 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1286640012838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338 1286640012839 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 1286640012840 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1286640012841 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1286640012842 active site 1286640012843 tetramer interface; other site 1286640012844 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1286640012845 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286640012846 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286640012847 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640012848 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 1286640012849 active site 1286640012850 catalytic triad [active] 1286640012851 oxyanion hole [active] 1286640012852 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1286640012853 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1286640012854 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1286640012855 active site 1286640012856 dimer interface [polypeptide binding]; other site 1286640012857 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1286640012858 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1286640012859 active site 1286640012860 FMN binding site [chemical binding]; other site 1286640012861 substrate binding site [chemical binding]; other site 1286640012862 3Fe-4S cluster binding site [ion binding]; other site 1286640012863 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1286640012864 domain interface; other site 1286640012865 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1286640012866 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1286640012867 tetramer interface [polypeptide binding]; other site 1286640012868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640012869 catalytic residue [active] 1286640012870 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1286640012871 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1286640012872 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1286640012873 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1286640012874 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640012875 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640012876 DNA binding residues [nucleotide binding] 1286640012877 dimerization interface [polypeptide binding]; other site 1286640012878 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1286640012879 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640012880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640012881 dimer interface [polypeptide binding]; other site 1286640012882 conserved gate region; other site 1286640012883 putative PBP binding loops; other site 1286640012884 ABC-ATPase subunit interface; other site 1286640012885 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1286640012886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640012887 dimer interface [polypeptide binding]; other site 1286640012888 conserved gate region; other site 1286640012889 putative PBP binding loops; other site 1286640012890 ABC-ATPase subunit interface; other site 1286640012891 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1286640012892 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640012893 Walker A/P-loop; other site 1286640012894 ATP binding site [chemical binding]; other site 1286640012895 Q-loop/lid; other site 1286640012896 ABC transporter signature motif; other site 1286640012897 Walker B; other site 1286640012898 D-loop; other site 1286640012899 H-loop/switch region; other site 1286640012900 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640012901 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640012902 Walker A/P-loop; other site 1286640012903 ATP binding site [chemical binding]; other site 1286640012904 Q-loop/lid; other site 1286640012905 ABC transporter signature motif; other site 1286640012906 Walker B; other site 1286640012907 D-loop; other site 1286640012908 H-loop/switch region; other site 1286640012909 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640012910 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1286640012911 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640012912 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1286640012913 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1286640012914 putative dimer interface [polypeptide binding]; other site 1286640012915 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1286640012916 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286640012917 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1286640012918 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1286640012919 active site 1286640012920 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 1286640012921 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640012922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640012923 active site 1286640012924 phosphorylation site [posttranslational modification] 1286640012925 intermolecular recognition site; other site 1286640012926 dimerization interface [polypeptide binding]; other site 1286640012927 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1286640012928 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1286640012929 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1286640012930 pseudoazurin; Region: pseudoazurin; TIGR02375 1286640012931 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286640012932 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1286640012933 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1286640012934 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1286640012935 Moco binding site; other site 1286640012936 metal coordination site [ion binding]; other site 1286640012937 dimerization interface [polypeptide binding]; other site 1286640012938 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1286640012939 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1286640012940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286640012941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640012942 DNA binding residues [nucleotide binding] 1286640012943 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286640012944 MarR family; Region: MarR; pfam01047 1286640012945 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 1286640012946 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640012947 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1286640012948 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640012949 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1286640012950 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640012951 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640012952 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640012953 dimerization interface [polypeptide binding]; other site 1286640012954 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640012955 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640012956 active site 1286640012957 catalytic tetrad [active] 1286640012958 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1286640012959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1286640012960 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1286640012961 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1286640012962 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1286640012963 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1286640012964 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1286640012965 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1286640012966 metal ion-dependent adhesion site (MIDAS); other site 1286640012967 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1286640012968 homodimer interface [polypeptide binding]; other site 1286640012969 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1286640012970 active site pocket [active] 1286640012971 glycogen branching enzyme; Provisional; Region: PRK05402 1286640012972 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1286640012973 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1286640012974 active site 1286640012975 catalytic site [active] 1286640012976 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1286640012977 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1286640012978 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1286640012979 ligand binding site; other site 1286640012980 oligomer interface; other site 1286640012981 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1286640012982 dimer interface [polypeptide binding]; other site 1286640012983 N-terminal domain interface [polypeptide binding]; other site 1286640012984 sulfate 1 binding site; other site 1286640012985 glycogen synthase; Provisional; Region: glgA; PRK00654 1286640012986 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1286640012987 ADP-binding pocket [chemical binding]; other site 1286640012988 homodimer interface [polypeptide binding]; other site 1286640012989 phosphoglucomutase; Region: PLN02307 1286640012990 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 1286640012991 substrate binding site [chemical binding]; other site 1286640012992 dimer interface [polypeptide binding]; other site 1286640012993 active site 1286640012994 metal binding site [ion binding]; metal-binding site 1286640012995 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1286640012996 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1286640012997 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1286640012998 active site 1286640012999 catalytic site [active] 1286640013000 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1286640013001 putative active site [active] 1286640013002 putative catalytic site [active] 1286640013003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 1286640013004 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1286640013005 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 1286640013006 NAD binding site [chemical binding]; other site 1286640013007 catalytic Zn binding site [ion binding]; other site 1286640013008 substrate binding site [chemical binding]; other site 1286640013009 structural Zn binding site [ion binding]; other site 1286640013010 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 1286640013011 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1286640013012 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1286640013013 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1286640013014 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 1286640013015 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1286640013016 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640013017 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1286640013018 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 1286640013019 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1286640013020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640013021 TPR motif; other site 1286640013022 binding surface 1286640013023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640013024 binding surface 1286640013025 TPR motif; other site 1286640013026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640013027 binding surface 1286640013028 TPR motif; other site 1286640013029 Protein of unknown function (DUF992); Region: DUF992; pfam06186 1286640013030 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640013031 cyclase homology domain; Region: CHD; cd07302 1286640013032 nucleotidyl binding site; other site 1286640013033 metal binding site [ion binding]; metal-binding site 1286640013034 dimer interface [polypeptide binding]; other site 1286640013035 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1286640013036 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1286640013037 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1286640013038 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1286640013039 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1286640013040 ligand binding site [chemical binding]; other site 1286640013041 homodimer interface [polypeptide binding]; other site 1286640013042 NAD(P) binding site [chemical binding]; other site 1286640013043 trimer interface B [polypeptide binding]; other site 1286640013044 trimer interface A [polypeptide binding]; other site 1286640013045 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 1286640013046 PAS domain; Region: PAS; smart00091 1286640013047 PAS fold; Region: PAS_7; pfam12860 1286640013048 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286640013049 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640013050 metal binding site [ion binding]; metal-binding site 1286640013051 active site 1286640013052 I-site; other site 1286640013053 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640013054 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1286640013055 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1286640013056 catalytic triad [active] 1286640013057 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1286640013058 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1286640013059 putative ligand binding site [chemical binding]; other site 1286640013060 NAD binding site [chemical binding]; other site 1286640013061 catalytic site [active] 1286640013062 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640013063 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640013064 DNA binding site [nucleotide binding] 1286640013065 domain linker motif; other site 1286640013066 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1286640013067 putative dimerization interface [polypeptide binding]; other site 1286640013068 putative ligand binding site [chemical binding]; other site 1286640013069 MarR family; Region: MarR_2; cl17246 1286640013070 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 1286640013071 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1286640013072 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1286640013073 P-loop, Walker A motif; other site 1286640013074 Base recognition motif; other site 1286640013075 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1286640013076 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1286640013077 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1286640013078 structural tetrad; other site 1286640013079 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286640013080 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1286640013081 Coenzyme A binding pocket [chemical binding]; other site 1286640013082 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1286640013083 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1286640013084 dimer interface [polypeptide binding]; other site 1286640013085 active site 1286640013086 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286640013087 catalytic residues [active] 1286640013088 substrate binding site [chemical binding]; other site 1286640013089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640013090 LysR family transcriptional regulator; Provisional; Region: PRK14997 1286640013091 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640013092 putative effector binding pocket; other site 1286640013093 dimerization interface [polypeptide binding]; other site 1286640013094 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1286640013095 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1286640013096 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1286640013097 putative active site [active] 1286640013098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1286640013099 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286640013100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286640013101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1286640013102 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1286640013103 putative metal binding site [ion binding]; other site 1286640013104 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1286640013105 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1286640013106 active site 1286640013107 intersubunit interface [polypeptide binding]; other site 1286640013108 catalytic residue [active] 1286640013109 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 1286640013110 putative active site [active] 1286640013111 putative metal binding residues [ion binding]; other site 1286640013112 signature motif; other site 1286640013113 putative dimer interface [polypeptide binding]; other site 1286640013114 putative phosphate binding site [ion binding]; other site 1286640013115 CHAD domain; Region: CHAD; pfam05235 1286640013116 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1286640013117 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1286640013118 active site residue [active] 1286640013119 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1286640013120 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1286640013121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640013122 dimer interface [polypeptide binding]; other site 1286640013123 conserved gate region; other site 1286640013124 ABC-ATPase subunit interface; other site 1286640013125 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1286640013126 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1286640013127 Walker A/P-loop; other site 1286640013128 ATP binding site [chemical binding]; other site 1286640013129 Q-loop/lid; other site 1286640013130 ABC transporter signature motif; other site 1286640013131 Walker B; other site 1286640013132 D-loop; other site 1286640013133 H-loop/switch region; other site 1286640013134 NIL domain; Region: NIL; pfam09383 1286640013135 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1286640013136 beta-galactosidase; Region: BGL; TIGR03356 1286640013137 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640013138 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640013139 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286640013140 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286640013141 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1286640013142 xylose isomerase; Provisional; Region: PRK05474 1286640013143 xylose isomerase; Region: xylose_isom_A; TIGR02630 1286640013144 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1286640013145 N- and C-terminal domain interface [polypeptide binding]; other site 1286640013146 D-xylulose kinase; Region: XylB; TIGR01312 1286640013147 active site 1286640013148 MgATP binding site [chemical binding]; other site 1286640013149 catalytic site [active] 1286640013150 metal binding site [ion binding]; metal-binding site 1286640013151 xylulose binding site [chemical binding]; other site 1286640013152 homodimer interface [polypeptide binding]; other site 1286640013153 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640013154 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640013155 DNA binding site [nucleotide binding] 1286640013156 domain linker motif; other site 1286640013157 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1286640013158 putative ligand binding site [chemical binding]; other site 1286640013159 Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion]; Region: COG5555 1286640013160 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1286640013161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640013162 putative substrate translocation pore; other site 1286640013163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640013164 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1286640013165 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640013166 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640013167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640013168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640013169 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1286640013170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640013171 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640013172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640013173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1286640013174 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1286640013175 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1286640013176 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1286640013177 HIGH motif; other site 1286640013178 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1286640013179 active site 1286640013180 KMSKS motif; other site 1286640013181 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1286640013182 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1286640013183 dimer interface [polypeptide binding]; other site 1286640013184 putative anticodon binding site; other site 1286640013185 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1286640013186 motif 1; other site 1286640013187 active site 1286640013188 motif 2; other site 1286640013189 motif 3; other site 1286640013190 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1286640013191 active site 1286640013192 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 1286640013193 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286640013194 ATP-dependent DNA ligase; Validated; Region: PRK09247 1286640013195 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 1286640013196 active site 1286640013197 DNA binding site [nucleotide binding] 1286640013198 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1286640013199 DNA binding site [nucleotide binding] 1286640013200 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3452 1286640013201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640013202 PAS fold; Region: PAS_3; pfam08447 1286640013203 putative active site [active] 1286640013204 heme pocket [chemical binding]; other site 1286640013205 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286640013206 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640013207 metal binding site [ion binding]; metal-binding site 1286640013208 active site 1286640013209 I-site; other site 1286640013210 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640013211 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1286640013212 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1286640013213 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286640013214 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1286640013215 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1286640013216 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 1286640013217 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1286640013218 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1286640013219 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286640013220 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 1286640013221 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1286640013222 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 1286640013223 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1286640013224 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286640013225 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640013226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640013227 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640013228 putative effector binding pocket; other site 1286640013229 dimerization interface [polypeptide binding]; other site 1286640013230 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1286640013231 active site 1286640013232 SAM binding site [chemical binding]; other site 1286640013233 homodimer interface [polypeptide binding]; other site 1286640013234 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1286640013235 active site 1286640013236 putative homodimer interface [polypeptide binding]; other site 1286640013237 SAM binding site [chemical binding]; other site 1286640013238 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1286640013239 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 1286640013240 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1286640013241 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1286640013242 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1286640013243 active site 1286640013244 SAM binding site [chemical binding]; other site 1286640013245 homodimer interface [polypeptide binding]; other site 1286640013246 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1286640013247 active site 1286640013248 SAM binding site [chemical binding]; other site 1286640013249 homodimer interface [polypeptide binding]; other site 1286640013250 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1286640013251 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1286640013252 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1286640013253 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1286640013254 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1286640013255 active site 1286640013256 SAM binding site [chemical binding]; other site 1286640013257 homodimer interface [polypeptide binding]; other site 1286640013258 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1286640013259 ligand binding site [chemical binding]; other site 1286640013260 active site 1286640013261 UGI interface [polypeptide binding]; other site 1286640013262 catalytic site [active] 1286640013263 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1286640013264 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286640013265 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1286640013266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640013267 dimer interface [polypeptide binding]; other site 1286640013268 conserved gate region; other site 1286640013269 putative PBP binding loops; other site 1286640013270 ABC-ATPase subunit interface; other site 1286640013271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640013272 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 1286640013273 Walker A/P-loop; other site 1286640013274 ATP binding site [chemical binding]; other site 1286640013275 Q-loop/lid; other site 1286640013276 ABC transporter signature motif; other site 1286640013277 Walker B; other site 1286640013278 D-loop; other site 1286640013279 H-loop/switch region; other site 1286640013280 TOBE domain; Region: TOBE; pfam03459 1286640013281 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1286640013282 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286640013283 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640013284 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 1286640013285 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1286640013286 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1286640013287 tetramer interface [polypeptide binding]; other site 1286640013288 TPP-binding site [chemical binding]; other site 1286640013289 heterodimer interface [polypeptide binding]; other site 1286640013290 phosphorylation loop region [posttranslational modification] 1286640013291 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1286640013292 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1286640013293 alpha subunit interface [polypeptide binding]; other site 1286640013294 TPP binding site [chemical binding]; other site 1286640013295 heterodimer interface [polypeptide binding]; other site 1286640013296 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286640013297 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1286640013298 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1286640013299 E3 interaction surface; other site 1286640013300 lipoyl attachment site [posttranslational modification]; other site 1286640013301 e3 binding domain; Region: E3_binding; pfam02817 1286640013302 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1286640013303 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1286640013304 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286640013305 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640013306 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286640013307 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1286640013308 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1286640013309 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1286640013310 putative active site [active] 1286640013311 putative substrate binding site [chemical binding]; other site 1286640013312 putative cosubstrate binding site; other site 1286640013313 catalytic site [active] 1286640013314 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1286640013315 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1286640013316 C-terminal domain interface [polypeptide binding]; other site 1286640013317 GSH binding site (G-site) [chemical binding]; other site 1286640013318 putative dimer interface [polypeptide binding]; other site 1286640013319 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1286640013320 dimer interface [polypeptide binding]; other site 1286640013321 N-terminal domain interface [polypeptide binding]; other site 1286640013322 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1286640013323 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1286640013324 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1286640013325 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1286640013326 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286640013327 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1286640013328 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640013329 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640013330 putative DNA binding site [nucleotide binding]; other site 1286640013331 putative Zn2+ binding site [ion binding]; other site 1286640013332 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640013333 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1286640013334 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1286640013335 dimer interface [polypeptide binding]; other site 1286640013336 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1286640013337 active site 1286640013338 Fe binding site [ion binding]; other site 1286640013339 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640013340 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640013341 DNA binding residues [nucleotide binding] 1286640013342 dimerization interface [polypeptide binding]; other site 1286640013343 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1286640013344 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640013345 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1286640013346 Walker A/P-loop; other site 1286640013347 ATP binding site [chemical binding]; other site 1286640013348 Q-loop/lid; other site 1286640013349 ABC transporter signature motif; other site 1286640013350 Walker B; other site 1286640013351 D-loop; other site 1286640013352 H-loop/switch region; other site 1286640013353 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1286640013354 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640013355 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640013356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640013357 TPR motif; other site 1286640013358 binding surface 1286640013359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640013360 binding surface 1286640013361 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1286640013362 TPR motif; other site 1286640013363 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1286640013364 Methyltransferase domain; Region: Methyltransf_25; pfam13649 1286640013365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640013366 I-site; other site 1286640013367 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640013368 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1286640013369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640013370 DNA-binding site [nucleotide binding]; DNA binding site 1286640013371 UTRA domain; Region: UTRA; pfam07702 1286640013372 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1286640013373 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1286640013374 putative active site [active] 1286640013375 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1286640013376 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286640013377 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1286640013378 substrate binding site [chemical binding]; other site 1286640013379 ATP binding site [chemical binding]; other site 1286640013380 Predicted nucleic-acid-binding protein, contains PIN domain [General function prediction only]; Region: COG5573 1286640013381 putative active site [active] 1286640013382 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1286640013383 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286640013384 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286640013385 Walker A/P-loop; other site 1286640013386 ATP binding site [chemical binding]; other site 1286640013387 Q-loop/lid; other site 1286640013388 ABC transporter signature motif; other site 1286640013389 Walker B; other site 1286640013390 D-loop; other site 1286640013391 H-loop/switch region; other site 1286640013392 EamA-like transporter family; Region: EamA; pfam00892 1286640013393 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640013394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640013395 dimer interface [polypeptide binding]; other site 1286640013396 conserved gate region; other site 1286640013397 putative PBP binding loops; other site 1286640013398 ABC-ATPase subunit interface; other site 1286640013399 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286640013400 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640013401 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286640013402 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640013403 substrate binding pocket [chemical binding]; other site 1286640013404 membrane-bound complex binding site; other site 1286640013405 hinge residues; other site 1286640013406 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286640013407 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1286640013408 AP (apurinic/apyrimidinic) site pocket; other site 1286640013409 DNA interaction; other site 1286640013410 Metal-binding active site; metal-binding site 1286640013411 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1286640013412 Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565 1286640013413 active site 1286640013414 catalytic site [active] 1286640013415 metal binding site [ion binding]; metal-binding site 1286640013416 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286640013417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286640013418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640013419 dimer interface [polypeptide binding]; other site 1286640013420 conserved gate region; other site 1286640013421 putative PBP binding loops; other site 1286640013422 ABC-ATPase subunit interface; other site 1286640013423 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640013424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640013425 dimer interface [polypeptide binding]; other site 1286640013426 conserved gate region; other site 1286640013427 putative PBP binding loops; other site 1286640013428 ABC-ATPase subunit interface; other site 1286640013429 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1286640013430 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640013431 Walker A/P-loop; other site 1286640013432 ATP binding site [chemical binding]; other site 1286640013433 Q-loop/lid; other site 1286640013434 ABC transporter signature motif; other site 1286640013435 Walker B; other site 1286640013436 D-loop; other site 1286640013437 H-loop/switch region; other site 1286640013438 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286640013439 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286640013440 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640013441 Walker A/P-loop; other site 1286640013442 ATP binding site [chemical binding]; other site 1286640013443 Q-loop/lid; other site 1286640013444 ABC transporter signature motif; other site 1286640013445 Walker B; other site 1286640013446 D-loop; other site 1286640013447 H-loop/switch region; other site 1286640013448 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286640013449 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640013450 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 1286640013451 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286640013452 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640013453 DNA binding residues [nucleotide binding] 1286640013454 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286640013455 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640013456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640013457 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1286640013458 dimerization interface [polypeptide binding]; other site 1286640013459 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1286640013460 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1286640013461 putative ligand binding site [chemical binding]; other site 1286640013462 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1286640013463 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1286640013464 Walker A/P-loop; other site 1286640013465 ATP binding site [chemical binding]; other site 1286640013466 Q-loop/lid; other site 1286640013467 ABC transporter signature motif; other site 1286640013468 Walker B; other site 1286640013469 D-loop; other site 1286640013470 H-loop/switch region; other site 1286640013471 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1286640013472 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1286640013473 Walker A/P-loop; other site 1286640013474 ATP binding site [chemical binding]; other site 1286640013475 Q-loop/lid; other site 1286640013476 ABC transporter signature motif; other site 1286640013477 Walker B; other site 1286640013478 D-loop; other site 1286640013479 H-loop/switch region; other site 1286640013480 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640013481 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1286640013482 TM-ABC transporter signature motif; other site 1286640013483 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1286640013484 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1286640013485 TM-ABC transporter signature motif; other site 1286640013486 choline dehydrogenase; Validated; Region: PRK02106 1286640013487 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1286640013488 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1286640013489 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1286640013490 MULE transposase domain; Region: MULE; pfam10551 1286640013491 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1286640013492 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1286640013493 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1286640013494 substrate binding pocket [chemical binding]; other site 1286640013495 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1286640013496 B12 binding site [chemical binding]; other site 1286640013497 cobalt ligand [ion binding]; other site 1286640013498 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1286640013499 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1286640013500 dimerization interface [polypeptide binding]; other site 1286640013501 putative active cleft [active] 1286640013502 hypothetical protein; Provisional; Region: PRK02487 1286640013503 fructokinase; Reviewed; Region: PRK09557 1286640013504 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286640013505 nucleotide binding site [chemical binding]; other site 1286640013506 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1286640013507 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 1286640013508 Predicted periplasmic protein [General function prediction only]; Region: COG3895 1286640013509 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1286640013510 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1286640013511 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1286640013512 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1286640013513 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1286640013514 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1286640013515 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1286640013516 substrate-cofactor binding pocket; other site 1286640013517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640013518 catalytic residue [active] 1286640013519 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1286640013520 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1286640013521 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1286640013522 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1286640013523 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640013524 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1286640013525 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1286640013526 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640013527 cyclase homology domain; Region: CHD; cd07302 1286640013528 nucleotidyl binding site; other site 1286640013529 metal binding site [ion binding]; metal-binding site 1286640013530 dimer interface [polypeptide binding]; other site 1286640013531 Predicted integral membrane protein [Function unknown]; Region: COG5616 1286640013532 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1286640013533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640013534 TPR motif; other site 1286640013535 binding surface 1286640013536 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286640013537 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1286640013538 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1286640013539 Surface antigen; Region: Bac_surface_Ag; pfam01103 1286640013540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1286640013541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1286640013542 Family of unknown function (DUF490); Region: DUF490; pfam04357 1286640013543 Family of unknown function (DUF490); Region: DUF490; pfam04357 1286640013544 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1286640013545 Phosphotransferase enzyme family; Region: APH; pfam01636 1286640013546 active site 1286640013547 ATP binding site [chemical binding]; other site 1286640013548 antibiotic binding site [chemical binding]; other site 1286640013549 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1286640013550 putative dimer interface [polypeptide binding]; other site 1286640013551 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640013552 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640013553 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1286640013554 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640013555 Arginase family; Region: Arginase; cd09989 1286640013556 active site 1286640013557 Mn binding site [ion binding]; other site 1286640013558 oligomer interface [polypeptide binding]; other site 1286640013559 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1286640013560 putative CheA interaction surface; other site 1286640013561 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1286640013562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1286640013563 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640013564 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640013565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640013566 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1286640013567 putative active site [active] 1286640013568 heme pocket [chemical binding]; other site 1286640013569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640013570 putative active site [active] 1286640013571 heme pocket [chemical binding]; other site 1286640013572 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286640013573 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286640013574 dimer interface [polypeptide binding]; other site 1286640013575 putative CheW interface [polypeptide binding]; other site 1286640013576 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 1286640013577 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1286640013578 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1286640013579 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640013580 catalytic loop [active] 1286640013581 iron binding site [ion binding]; other site 1286640013582 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1286640013583 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1286640013584 [4Fe-4S] binding site [ion binding]; other site 1286640013585 molybdopterin cofactor binding site; other site 1286640013586 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1286640013587 molybdopterin cofactor binding site; other site 1286640013588 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 1286640013589 putative dimer interface [polypeptide binding]; other site 1286640013590 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1286640013591 SLBB domain; Region: SLBB; pfam10531 1286640013592 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1286640013593 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 1286640013594 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 1286640013595 putative dimer interface [polypeptide binding]; other site 1286640013596 [2Fe-2S] cluster binding site [ion binding]; other site 1286640013597 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640013598 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640013599 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286640013600 dimerization interface [polypeptide binding]; other site 1286640013601 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1286640013602 classical (c) SDRs; Region: SDR_c; cd05233 1286640013603 NAD(P) binding site [chemical binding]; other site 1286640013604 active site 1286640013605 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1286640013606 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1286640013607 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286640013608 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1286640013609 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286640013610 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1286640013611 Walker A/P-loop; other site 1286640013612 ATP binding site [chemical binding]; other site 1286640013613 Q-loop/lid; other site 1286640013614 ABC transporter signature motif; other site 1286640013615 Walker B; other site 1286640013616 D-loop; other site 1286640013617 H-loop/switch region; other site 1286640013618 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286640013619 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1286640013620 Walker A/P-loop; other site 1286640013621 ATP binding site [chemical binding]; other site 1286640013622 Q-loop/lid; other site 1286640013623 ABC transporter signature motif; other site 1286640013624 Walker B; other site 1286640013625 D-loop; other site 1286640013626 H-loop/switch region; other site 1286640013627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640013628 dimer interface [polypeptide binding]; other site 1286640013629 conserved gate region; other site 1286640013630 putative PBP binding loops; other site 1286640013631 ABC-ATPase subunit interface; other site 1286640013632 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640013633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640013634 dimer interface [polypeptide binding]; other site 1286640013635 conserved gate region; other site 1286640013636 putative PBP binding loops; other site 1286640013637 ABC-ATPase subunit interface; other site 1286640013638 Predicted small integral membrane protein [Function unknown]; Region: COG5477 1286640013639 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640013640 xanthine permease; Region: pbuX; TIGR03173 1286640013641 xanthine permease; Region: pbuX; TIGR03173 1286640013642 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1286640013643 EamA-like transporter family; Region: EamA; pfam00892 1286640013644 EamA-like transporter family; Region: EamA; pfam00892 1286640013645 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1286640013646 metal binding site 2 [ion binding]; metal-binding site 1286640013647 putative DNA binding helix; other site 1286640013648 metal binding site 1 [ion binding]; metal-binding site 1286640013649 dimer interface [polypeptide binding]; other site 1286640013650 structural Zn2+ binding site [ion binding]; other site 1286640013651 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1286640013652 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1286640013653 metal binding site [ion binding]; metal-binding site 1286640013654 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1286640013655 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1286640013656 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1286640013657 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286640013658 ABC-ATPase subunit interface; other site 1286640013659 dimer interface [polypeptide binding]; other site 1286640013660 putative PBP binding regions; other site 1286640013661 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1286640013662 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286640013663 ABC-ATPase subunit interface; other site 1286640013664 dimer interface [polypeptide binding]; other site 1286640013665 putative PBP binding regions; other site 1286640013666 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640013667 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1286640013668 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640013669 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1286640013670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640013671 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1286640013672 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1286640013673 gamma subunit interface [polypeptide binding]; other site 1286640013674 epsilon subunit interface [polypeptide binding]; other site 1286640013675 LBP interface [polypeptide binding]; other site 1286640013676 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1286640013677 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1286640013678 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1286640013679 alpha subunit interaction interface [polypeptide binding]; other site 1286640013680 Walker A motif; other site 1286640013681 ATP binding site [chemical binding]; other site 1286640013682 Walker B motif; other site 1286640013683 inhibitor binding site; inhibition site 1286640013684 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1286640013685 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1286640013686 core domain interface [polypeptide binding]; other site 1286640013687 delta subunit interface [polypeptide binding]; other site 1286640013688 epsilon subunit interface [polypeptide binding]; other site 1286640013689 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1286640013690 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1286640013691 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1286640013692 beta subunit interaction interface [polypeptide binding]; other site 1286640013693 Walker A motif; other site 1286640013694 ATP binding site [chemical binding]; other site 1286640013695 Walker B motif; other site 1286640013696 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1286640013697 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1286640013698 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1286640013699 primosome assembly protein PriA; Validated; Region: PRK05580 1286640013700 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286640013701 ATP binding site [chemical binding]; other site 1286640013702 putative Mg++ binding site [ion binding]; other site 1286640013703 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1286640013704 nucleotide binding region [chemical binding]; other site 1286640013705 ATP-binding site [chemical binding]; other site 1286640013706 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1286640013707 active site 1286640013708 intersubunit interactions; other site 1286640013709 catalytic residue [active] 1286640013710 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286640013711 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 1286640013712 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1286640013713 Protein of unknown function (DUF560); Region: DUF560; pfam04575 1286640013714 Predicted ATPase [General function prediction only]; Region: COG4637 1286640013715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640013716 Walker A/P-loop; other site 1286640013717 ATP binding site [chemical binding]; other site 1286640013718 Putative hemolysin [General function prediction only]; Region: COG3176 1286640013719 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1286640013720 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1286640013721 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286640013722 active site 1286640013723 DNA binding site [nucleotide binding] 1286640013724 Int/Topo IB signature motif; other site 1286640013725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 1286640013726 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 1286640013727 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286640013728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640013729 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286640013730 short chain dehydrogenase; Provisional; Region: PRK06123 1286640013731 classical (c) SDRs; Region: SDR_c; cd05233 1286640013732 NAD(P) binding site [chemical binding]; other site 1286640013733 active site 1286640013734 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286640013735 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1286640013736 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1286640013737 E3 interaction surface; other site 1286640013738 lipoyl attachment site [posttranslational modification]; other site 1286640013739 e3 binding domain; Region: E3_binding; pfam02817 1286640013740 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1286640013741 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1286640013742 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1286640013743 TPP-binding site [chemical binding]; other site 1286640013744 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1286640013745 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1286640013746 CoA binding domain; Region: CoA_binding; smart00881 1286640013747 CoA-ligase; Region: Ligase_CoA; pfam00549 1286640013748 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1286640013749 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1286640013750 CoA-ligase; Region: Ligase_CoA; pfam00549 1286640013751 malate dehydrogenase; Reviewed; Region: PRK06223 1286640013752 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1286640013753 NAD(P) binding site [chemical binding]; other site 1286640013754 dimer interface [polypeptide binding]; other site 1286640013755 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286640013756 substrate binding site [chemical binding]; other site 1286640013757 Predicted ATPase [General function prediction only]; Region: COG1485 1286640013758 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1286640013759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640013760 sequence-specific DNA binding site [nucleotide binding]; other site 1286640013761 salt bridge; other site 1286640013762 Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549 1286640013763 Protease inhibitor Inh; Region: Inh; pfam02974 1286640013764 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640013765 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640013766 Walker A/P-loop; other site 1286640013767 ATP binding site [chemical binding]; other site 1286640013768 Q-loop/lid; other site 1286640013769 ABC transporter signature motif; other site 1286640013770 Walker B; other site 1286640013771 D-loop; other site 1286640013772 H-loop/switch region; other site 1286640013773 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640013774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640013775 dimer interface [polypeptide binding]; other site 1286640013776 conserved gate region; other site 1286640013777 putative PBP binding loops; other site 1286640013778 ABC-ATPase subunit interface; other site 1286640013779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640013780 dimer interface [polypeptide binding]; other site 1286640013781 conserved gate region; other site 1286640013782 putative PBP binding loops; other site 1286640013783 ABC-ATPase subunit interface; other site 1286640013784 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640013785 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640013786 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1286640013787 putative Zn2+ binding site [ion binding]; other site 1286640013788 putative DNA binding site [nucleotide binding]; other site 1286640013789 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286640013790 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286640013791 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640013792 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640013793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828 1286640013794 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1286640013795 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1286640013796 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1286640013797 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 1286640013798 L-aspartate oxidase; Provisional; Region: PRK06175 1286640013799 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1286640013800 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 1286640013801 putative SdhC subunit interface [polypeptide binding]; other site 1286640013802 putative proximal heme binding site [chemical binding]; other site 1286640013803 putative Iron-sulfur protein interface [polypeptide binding]; other site 1286640013804 putative proximal quinone binding site; other site 1286640013805 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1286640013806 Iron-sulfur protein interface; other site 1286640013807 proximal quinone binding site [chemical binding]; other site 1286640013808 SdhD (CybS) interface [polypeptide binding]; other site 1286640013809 proximal heme binding site [chemical binding]; other site 1286640013810 Predicted methyltransferase [General function prediction only]; Region: COG3897 1286640013811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1286640013812 Uncharacterized conserved protein [Function unknown]; Region: COG2947 1286640013813 YciI-like protein; Reviewed; Region: PRK12865 1286640013814 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1286640013815 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1286640013816 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1286640013817 UGMP family protein; Validated; Region: PRK09604 1286640013818 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1286640013819 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1286640013820 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1286640013821 domain interfaces; other site 1286640013822 active site 1286640013823 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1286640013824 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1286640013825 active site 1286640013826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 1286640013827 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 1286640013828 HemY protein N-terminus; Region: HemY_N; pfam07219 1286640013829 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 1286640013830 putative metal binding site [ion binding]; other site 1286640013831 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1286640013832 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1286640013833 catalytic triad [active] 1286640013834 enterobactin exporter EntS; Provisional; Region: PRK10489 1286640013835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640013836 putative substrate translocation pore; other site 1286640013837 YGGT family; Region: YGGT; pfam02325 1286640013838 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1286640013839 dimer interface [polypeptide binding]; other site 1286640013840 substrate binding site [chemical binding]; other site 1286640013841 metal binding sites [ion binding]; metal-binding site 1286640013842 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286640013843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640013844 Coenzyme A binding pocket [chemical binding]; other site 1286640013845 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1286640013846 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1286640013847 G1 box; other site 1286640013848 putative GEF interaction site [polypeptide binding]; other site 1286640013849 GTP/Mg2+ binding site [chemical binding]; other site 1286640013850 Switch I region; other site 1286640013851 G2 box; other site 1286640013852 G3 box; other site 1286640013853 Switch II region; other site 1286640013854 G4 box; other site 1286640013855 G5 box; other site 1286640013856 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1286640013857 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1286640013858 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1286640013859 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1286640013860 putative active site [active] 1286640013861 putative metal binding site [ion binding]; other site 1286640013862 KTSC domain; Region: KTSC; pfam13619 1286640013863 amidase; Provisional; Region: PRK07056 1286640013864 amidase; Validated; Region: PRK05962 1286640013865 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1286640013866 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1286640013867 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640013868 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640013869 integrase; Provisional; Region: PRK09692 1286640013870 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1286640013871 active site 1286640013872 Int/Topo IB signature motif; other site 1286640013873 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1286640013874 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286640013875 active site 1286640013876 DNA binding site [nucleotide binding] 1286640013877 Int/Topo IB signature motif; other site 1286640013878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1286640013879 putative transposase OrfB; Reviewed; Region: PHA02517 1286640013880 HTH-like domain; Region: HTH_21; pfam13276 1286640013881 Integrase core domain; Region: rve; pfam00665 1286640013882 Integrase core domain; Region: rve_3; pfam13683 1286640013883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1286640013884 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1286640013885 Transposase; Region: HTH_Tnp_1; pfam01527 1286640013886 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286640013887 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1286640013888 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 1286640013889 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1286640013890 nucleotide binding site [chemical binding]; other site 1286640013891 homotetrameric interface [polypeptide binding]; other site 1286640013892 putative phosphate binding site [ion binding]; other site 1286640013893 putative allosteric binding site; other site 1286640013894 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; pfam05118 1286640013895 L-proline 3-hydroxylase, C-terminal; Region: Pro_3_hydrox_C; pfam05373 1286640013896 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1286640013897 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; pfam05118 1286640013898 L-proline 3-hydroxylase, C-terminal; Region: Pro_3_hydrox_C; pfam05373 1286640013899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1286640013900 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1286640013901 Integrase core domain; Region: rve; pfam00665 1286640013902 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640013903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640013904 DNA-binding site [nucleotide binding]; DNA binding site 1286640013905 FCD domain; Region: FCD; pfam07729 1286640013906 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286640013907 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1286640013908 inhibitor site; inhibition site 1286640013909 active site 1286640013910 dimer interface [polypeptide binding]; other site 1286640013911 catalytic residue [active] 1286640013912 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1286640013913 Transposase domain (DUF772); Region: DUF772; pfam05598 1286640013914 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1286640013915 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1286640013916 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1286640013917 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 1286640013918 active site 1286640013919 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640013920 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640013921 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1286640013922 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1286640013923 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 1286640013924 active site 1286640013925 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1286640013926 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640013927 Walker A/P-loop; other site 1286640013928 ATP binding site [chemical binding]; other site 1286640013929 Q-loop/lid; other site 1286640013930 ABC transporter signature motif; other site 1286640013931 Walker B; other site 1286640013932 D-loop; other site 1286640013933 H-loop/switch region; other site 1286640013934 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1286640013935 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640013936 Walker A/P-loop; other site 1286640013937 ATP binding site [chemical binding]; other site 1286640013938 Q-loop/lid; other site 1286640013939 ABC transporter signature motif; other site 1286640013940 Walker B; other site 1286640013941 D-loop; other site 1286640013942 H-loop/switch region; other site 1286640013943 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1286640013944 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640013945 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1286640013946 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640013947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640013948 dimer interface [polypeptide binding]; other site 1286640013949 conserved gate region; other site 1286640013950 putative PBP binding loops; other site 1286640013951 ABC-ATPase subunit interface; other site 1286640013952 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286640013953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640013954 putative PBP binding loops; other site 1286640013955 dimer interface [polypeptide binding]; other site 1286640013956 ABC-ATPase subunit interface; other site 1286640013957 Transmembrane secretion effector; Region: MFS_3; pfam05977 1286640013958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640013959 putative substrate translocation pore; other site 1286640013960 Transposase; Region: HTH_Tnp_1; pfam01527 1286640013961 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286640013962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1286640013963 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1286640013964 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1286640013965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1286640013966 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1286640013967 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1286640013968 transposase; Validated; Region: PRK08181 1286640013969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640013970 Walker A motif; other site 1286640013971 ATP binding site [chemical binding]; other site 1286640013972 Integrase core domain; Region: rve; pfam00665 1286640013973 Integrase core domain; Region: rve; pfam00665 1286640013974 Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5640 1286640013975 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1286640013976 active site 1286640013977 substrate binding sites [chemical binding]; other site 1286640013978 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 1286640013979 Divergent AAA domain; Region: AAA_4; pfam04326 1286640013980 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1286640013981 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1286640013982 Uncharacterized conserved protein [Function unknown]; Region: COG5586 1286640013983 Transposase; Region: HTH_Tnp_1; cl17663 1286640013984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286640013985 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 1286640013986 HTH-like domain; Region: HTH_21; pfam13276 1286640013987 Integrase core domain; Region: rve; pfam00665 1286640013988 Integrase core domain; Region: rve_3; pfam13683 1286640013989 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1286640013990 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1286640013991 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1286640013992 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1286640013993 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1286640013994 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1286640013995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1286640013996 Transposase; Region: HTH_Tnp_1; pfam01527 1286640013997 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286640013998 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1286640013999 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1286640014000 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1286640014001 ATP binding site [chemical binding]; other site 1286640014002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286640014003 ATP-binding site [chemical binding]; other site 1286640014004 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1286640014005 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1286640014006 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1286640014007 DNA binding site [nucleotide binding] 1286640014008 substrate interaction site [chemical binding]; other site 1286640014009 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1286640014010 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1286640014011 additional DNA contacts [nucleotide binding]; other site 1286640014012 mismatch recognition site; other site 1286640014013 active site 1286640014014 zinc binding site [ion binding]; other site 1286640014015 DNA intercalation site [nucleotide binding]; other site 1286640014016 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640014017 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 1286640014018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286640014019 FeS/SAM binding site; other site 1286640014020 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1286640014021 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1286640014022 Predicted chitinase [General function prediction only]; Region: COG3179 1286640014023 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640014024 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1286640014025 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1286640014026 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1286640014027 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1286640014028 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286640014029 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286640014030 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286640014031 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286640014032 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1286640014033 GTP1/OBG; Region: GTP1_OBG; pfam01018 1286640014034 Obg GTPase; Region: Obg; cd01898 1286640014035 G1 box; other site 1286640014036 GTP/Mg2+ binding site [chemical binding]; other site 1286640014037 Switch I region; other site 1286640014038 G2 box; other site 1286640014039 G3 box; other site 1286640014040 Switch II region; other site 1286640014041 G4 box; other site 1286640014042 G5 box; other site 1286640014043 gamma-glutamyl kinase; Provisional; Region: PRK05429 1286640014044 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1286640014045 nucleotide binding site [chemical binding]; other site 1286640014046 homotetrameric interface [polypeptide binding]; other site 1286640014047 putative phosphate binding site [ion binding]; other site 1286640014048 putative allosteric binding site; other site 1286640014049 PUA domain; Region: PUA; pfam01472 1286640014050 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1286640014051 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1286640014052 putative catalytic cysteine [active] 1286640014053 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1286640014054 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1286640014055 active site 1286640014056 (T/H)XGH motif; other site 1286640014057 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1286640014058 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1286640014059 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1286640014060 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286640014061 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1286640014062 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1286640014063 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1286640014064 protein binding site [polypeptide binding]; other site 1286640014065 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1286640014066 Catalytic dyad [active] 1286640014067 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1286640014068 NodB motif; other site 1286640014069 putative active site [active] 1286640014070 putative catalytic site [active] 1286640014071 Zn binding site [ion binding]; other site 1286640014072 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1286640014073 putative active site [active] 1286640014074 Ap4A binding site [chemical binding]; other site 1286640014075 nudix motif; other site 1286640014076 putative metal binding site [ion binding]; other site 1286640014077 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1286640014078 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1286640014079 heme binding site [chemical binding]; other site 1286640014080 ferroxidase pore; other site 1286640014081 ferroxidase diiron center [ion binding]; other site 1286640014082 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1286640014083 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1286640014084 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1286640014085 putative active site [active] 1286640014086 putative PHP Thumb interface [polypeptide binding]; other site 1286640014087 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1286640014088 generic binding surface II; other site 1286640014089 generic binding surface I; other site 1286640014090 DNA Polymerase Y-family; Region: PolY_like; cd03468 1286640014091 active site 1286640014092 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1286640014093 DNA binding site [nucleotide binding] 1286640014094 Uncharacterized conserved protein [Function unknown]; Region: COG4544 1286640014095 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1286640014096 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 1286640014097 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1286640014098 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1286640014099 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1286640014100 substrate binding site [chemical binding]; other site 1286640014101 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1286640014102 homotrimer interaction site [polypeptide binding]; other site 1286640014103 putative active site [active] 1286640014104 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 1286640014105 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1286640014106 proposed active site lysine [active] 1286640014107 conserved cys residue [active] 1286640014108 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1286640014109 active site 1286640014110 catalytic residues [active] 1286640014111 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1286640014112 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1286640014113 P-loop, Walker A motif; other site 1286640014114 Base recognition motif; other site 1286640014115 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1286640014116 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1286640014117 putative deacylase active site [active] 1286640014118 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1286640014119 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1286640014120 catalytic residues [active] 1286640014121 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1286640014122 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1286640014123 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 1286640014124 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1286640014125 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1286640014126 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1286640014127 active site 1286640014128 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1286640014129 catalytic triad [active] 1286640014130 dimer interface [polypeptide binding]; other site 1286640014131 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1286640014132 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1286640014133 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1286640014134 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1286640014135 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1286640014136 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1286640014137 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1286640014138 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1286640014139 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1286640014140 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286640014141 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286640014142 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640014143 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640014144 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1286640014145 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286640014146 ligand binding site [chemical binding]; other site 1286640014147 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640014148 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640014149 TM-ABC transporter signature motif; other site 1286640014150 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1286640014151 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640014152 Walker A/P-loop; other site 1286640014153 ATP binding site [chemical binding]; other site 1286640014154 Q-loop/lid; other site 1286640014155 ABC transporter signature motif; other site 1286640014156 Walker B; other site 1286640014157 D-loop; other site 1286640014158 H-loop/switch region; other site 1286640014159 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286640014160 MarR family; Region: MarR_2; pfam12802 1286640014161 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286640014162 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286640014163 nucleotide binding site [chemical binding]; other site 1286640014164 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286640014165 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286640014166 nucleotide binding site [chemical binding]; other site 1286640014167 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1286640014168 putative catalytic site [active] 1286640014169 putative phosphate binding site [ion binding]; other site 1286640014170 active site 1286640014171 metal binding site A [ion binding]; metal-binding site 1286640014172 DNA binding site [nucleotide binding] 1286640014173 putative AP binding site [nucleotide binding]; other site 1286640014174 putative metal binding site B [ion binding]; other site 1286640014175 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286640014176 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286640014177 ligand binding site [chemical binding]; other site 1286640014178 flexible hinge region; other site 1286640014179 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640014180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640014181 active site 1286640014182 phosphorylation site [posttranslational modification] 1286640014183 intermolecular recognition site; other site 1286640014184 dimerization interface [polypeptide binding]; other site 1286640014185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640014186 DNA binding site [nucleotide binding] 1286640014187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1286640014188 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286640014189 catalytic core [active] 1286640014190 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1286640014191 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1286640014192 substrate binding site [chemical binding]; other site 1286640014193 ligand binding site [chemical binding]; other site 1286640014194 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286640014195 MarR family; Region: MarR_2; pfam12802 1286640014196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640014197 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286640014198 putative substrate translocation pore; other site 1286640014199 argininosuccinate synthase; Provisional; Region: PRK13820 1286640014200 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1286640014201 ANP binding site [chemical binding]; other site 1286640014202 Substrate Binding Site II [chemical binding]; other site 1286640014203 Substrate Binding Site I [chemical binding]; other site 1286640014204 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286640014205 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1286640014206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640014207 Walker A/P-loop; other site 1286640014208 ATP binding site [chemical binding]; other site 1286640014209 Q-loop/lid; other site 1286640014210 ABC transporter signature motif; other site 1286640014211 Walker B; other site 1286640014212 D-loop; other site 1286640014213 H-loop/switch region; other site 1286640014214 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640014215 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1286640014216 TM-ABC transporter signature motif; other site 1286640014217 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1286640014218 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286640014219 zinc binding site [ion binding]; other site 1286640014220 putative ligand binding site [chemical binding]; other site 1286640014221 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1286640014222 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286640014223 FeS/SAM binding site; other site 1286640014224 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1286640014225 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1286640014226 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 1286640014227 aromatic arch; other site 1286640014228 DCoH dimer interaction site [polypeptide binding]; other site 1286640014229 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1286640014230 DCoH tetramer interaction site [polypeptide binding]; other site 1286640014231 substrate binding site [chemical binding]; other site 1286640014232 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1286640014233 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1286640014234 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1286640014235 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1286640014236 active site 1286640014237 catalytic triad [active] 1286640014238 oxyanion hole [active] 1286640014239 switch loop; other site 1286640014240 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1286640014241 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286640014242 Walker A/P-loop; other site 1286640014243 ATP binding site [chemical binding]; other site 1286640014244 Q-loop/lid; other site 1286640014245 ABC transporter signature motif; other site 1286640014246 Walker B; other site 1286640014247 D-loop; other site 1286640014248 H-loop/switch region; other site 1286640014249 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1286640014250 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1286640014251 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1286640014252 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1286640014253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640014254 Coenzyme A binding pocket [chemical binding]; other site 1286640014255 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1286640014256 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1286640014257 oligomer interface [polypeptide binding]; other site 1286640014258 active site residues [active] 1286640014259 Uncharacterized conserved protein [Function unknown]; Region: COG3832 1286640014260 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640014261 dimerization interface [polypeptide binding]; other site 1286640014262 putative DNA binding site [nucleotide binding]; other site 1286640014263 putative Zn2+ binding site [ion binding]; other site 1286640014264 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 1286640014265 Uncharacterized secreted protein [Function unknown]; Region: COG5429 1286640014266 aconitate hydratase; Validated; Region: PRK09277 1286640014267 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1286640014268 substrate binding site [chemical binding]; other site 1286640014269 ligand binding site [chemical binding]; other site 1286640014270 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1286640014271 substrate binding site [chemical binding]; other site 1286640014272 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 1286640014273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640014274 Walker A/P-loop; other site 1286640014275 ATP binding site [chemical binding]; other site 1286640014276 Q-loop/lid; other site 1286640014277 ABC transporter signature motif; other site 1286640014278 Walker B; other site 1286640014279 D-loop; other site 1286640014280 H-loop/switch region; other site 1286640014281 heme exporter protein CcmB; Region: ccmB; TIGR01190 1286640014282 heme exporter protein CcmC; Region: ccmC; TIGR01191 1286640014283 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1286640014284 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1286640014285 catalytic residues [active] 1286640014286 central insert; other site 1286640014287 hypothetical protein; Provisional; Region: PRK00944 1286640014288 intracellular septation protein A; Reviewed; Region: PRK00259 1286640014289 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1286640014290 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1286640014291 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1286640014292 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1286640014293 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1286640014294 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286640014295 FeS/SAM binding site; other site 1286640014296 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 1286640014297 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1286640014298 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1286640014299 signal recognition particle protein; Provisional; Region: PRK10867 1286640014300 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1286640014301 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1286640014302 P loop; other site 1286640014303 GTP binding site [chemical binding]; other site 1286640014304 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1286640014305 chorismate mutase; Provisional; Region: PRK09239 1286640014306 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1286640014307 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1286640014308 RimM N-terminal domain; Region: RimM; pfam01782 1286640014309 PRC-barrel domain; Region: PRC; pfam05239 1286640014310 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1286640014311 hypothetical protein; Provisional; Region: PRK10621 1286640014312 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286640014313 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1286640014314 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286640014315 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640014316 substrate binding pocket [chemical binding]; other site 1286640014317 membrane-bound complex binding site; other site 1286640014318 hinge residues; other site 1286640014319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640014320 dimer interface [polypeptide binding]; other site 1286640014321 conserved gate region; other site 1286640014322 putative PBP binding loops; other site 1286640014323 ABC-ATPase subunit interface; other site 1286640014324 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1286640014325 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286640014326 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286640014327 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1286640014328 Thiamine pyrophosphokinase; Region: TPK; cd07995 1286640014329 active site 1286640014330 dimerization interface [polypeptide binding]; other site 1286640014331 thiamine binding site [chemical binding]; other site 1286640014332 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1286640014333 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1286640014334 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1286640014335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640014336 ABC-ATPase subunit interface; other site 1286640014337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286640014338 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 1286640014339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640014340 Walker A/P-loop; other site 1286640014341 ATP binding site [chemical binding]; other site 1286640014342 Q-loop/lid; other site 1286640014343 ABC transporter signature motif; other site 1286640014344 Walker B; other site 1286640014345 D-loop; other site 1286640014346 H-loop/switch region; other site 1286640014347 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 1286640014348 Peptidase family M48; Region: Peptidase_M48; pfam01435 1286640014349 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1286640014350 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 1286640014351 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286640014352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640014353 DNA binding residues [nucleotide binding] 1286640014354 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1286640014355 Ferredoxin [Energy production and conversion]; Region: COG1146 1286640014356 4Fe-4S binding domain; Region: Fer4; pfam00037 1286640014357 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1286640014358 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286640014359 RNA binding surface [nucleotide binding]; other site 1286640014360 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286640014361 ATP binding site [chemical binding]; other site 1286640014362 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1286640014363 putative Mg++ binding site [ion binding]; other site 1286640014364 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286640014365 nucleotide binding region [chemical binding]; other site 1286640014366 ATP-binding site [chemical binding]; other site 1286640014367 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1286640014368 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1286640014369 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1286640014370 NAD(P) binding site [chemical binding]; other site 1286640014371 homotetramer interface [polypeptide binding]; other site 1286640014372 homodimer interface [polypeptide binding]; other site 1286640014373 active site 1286640014374 putative acyltransferase; Provisional; Region: PRK05790 1286640014375 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286640014376 dimer interface [polypeptide binding]; other site 1286640014377 active site 1286640014378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 1286640014379 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 1286640014380 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1286640014381 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 1286640014382 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1286640014383 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640014384 putative C-terminal domain interface [polypeptide binding]; other site 1286640014385 putative GSH binding site (G-site) [chemical binding]; other site 1286640014386 putative dimer interface [polypeptide binding]; other site 1286640014387 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1286640014388 putative dimer interface [polypeptide binding]; other site 1286640014389 putative N-terminal domain interface [polypeptide binding]; other site 1286640014390 putative substrate binding pocket (H-site) [chemical binding]; other site 1286640014391 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1286640014392 Transglycosylase; Region: Transgly; cl17702 1286640014393 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1286640014394 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1286640014395 substrate binding pocket [chemical binding]; other site 1286640014396 chain length determination region; other site 1286640014397 substrate-Mg2+ binding site; other site 1286640014398 catalytic residues [active] 1286640014399 aspartate-rich region 1; other site 1286640014400 active site lid residues [active] 1286640014401 aspartate-rich region 2; other site 1286640014402 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1286640014403 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640014404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640014405 homodimer interface [polypeptide binding]; other site 1286640014406 catalytic residue [active] 1286640014407 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1286640014408 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286640014409 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1286640014410 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1286640014411 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286640014412 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1286640014413 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1286640014414 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1286640014415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640014416 putative substrate translocation pore; other site 1286640014417 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1286640014418 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1286640014419 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286640014420 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286640014421 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640014422 substrate binding pocket [chemical binding]; other site 1286640014423 membrane-bound complex binding site; other site 1286640014424 hinge residues; other site 1286640014425 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1286640014426 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286640014427 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1286640014428 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1286640014429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640014430 dimer interface [polypeptide binding]; other site 1286640014431 conserved gate region; other site 1286640014432 putative PBP binding loops; other site 1286640014433 ABC-ATPase subunit interface; other site 1286640014434 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286640014435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640014436 Walker A/P-loop; other site 1286640014437 ATP binding site [chemical binding]; other site 1286640014438 Q-loop/lid; other site 1286640014439 ABC transporter signature motif; other site 1286640014440 Walker B; other site 1286640014441 D-loop; other site 1286640014442 H-loop/switch region; other site 1286640014443 pyruvate carboxylase; Reviewed; Region: PRK12999 1286640014444 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286640014445 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1286640014446 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1286640014447 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1286640014448 active site 1286640014449 catalytic residues [active] 1286640014450 metal binding site [ion binding]; metal-binding site 1286640014451 homodimer binding site [polypeptide binding]; other site 1286640014452 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1286640014453 carboxyltransferase (CT) interaction site; other site 1286640014454 biotinylation site [posttranslational modification]; other site 1286640014455 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1286640014456 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640014457 DNA binding residues [nucleotide binding] 1286640014458 dimerization interface [polypeptide binding]; other site 1286640014459 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 1286640014460 HTH-like domain; Region: HTH_21; pfam13276 1286640014461 Integrase core domain; Region: rve; pfam00665 1286640014462 Integrase core domain; Region: rve_3; pfam13683 1286640014463 Transposase; Region: HTH_Tnp_1; cl17663 1286640014464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286640014465 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1286640014466 glucan exporter ATP-binding protein; Region: chvA; TIGR01192 1286640014467 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640014468 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1286640014469 Walker A/P-loop; other site 1286640014470 ATP binding site [chemical binding]; other site 1286640014471 Q-loop/lid; other site 1286640014472 ABC transporter signature motif; other site 1286640014473 Walker B; other site 1286640014474 D-loop; other site 1286640014475 H-loop/switch region; other site 1286640014476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645 1286640014477 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1286640014478 Putative glucoamylase; Region: Glycoamylase; pfam10091 1286640014479 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1286640014480 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1286640014481 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1286640014482 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286640014483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640014484 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1286640014485 dimerization interface [polypeptide binding]; other site 1286640014486 substrate binding pocket [chemical binding]; other site 1286640014487 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1286640014488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1286640014489 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286640014490 FAD binding domain; Region: FAD_binding_4; pfam01565 1286640014491 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1286640014492 aldehyde dehydrogenase family 7 member; Region: PLN02315 1286640014493 tetrameric interface [polypeptide binding]; other site 1286640014494 NAD binding site [chemical binding]; other site 1286640014495 catalytic residues [active] 1286640014496 aspartate aminotransferase; Provisional; Region: PRK05764 1286640014497 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640014498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640014499 homodimer interface [polypeptide binding]; other site 1286640014500 catalytic residue [active] 1286640014501 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1286640014502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640014503 non-specific DNA binding site [nucleotide binding]; other site 1286640014504 salt bridge; other site 1286640014505 sequence-specific DNA binding site [nucleotide binding]; other site 1286640014506 Cupin domain; Region: Cupin_2; pfam07883 1286640014507 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1286640014508 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640014509 inhibitor-cofactor binding pocket; inhibition site 1286640014510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640014511 catalytic residue [active] 1286640014512 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1286640014513 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1286640014514 MOFRL family; Region: MOFRL; pfam05161 1286640014515 choline dehydrogenase; Validated; Region: PRK02106 1286640014516 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1286640014517 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1286640014518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640014519 NAD(P) binding site [chemical binding]; other site 1286640014520 active site 1286640014521 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1286640014522 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1286640014523 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640014524 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640014525 Walker A/P-loop; other site 1286640014526 ATP binding site [chemical binding]; other site 1286640014527 Q-loop/lid; other site 1286640014528 ABC transporter signature motif; other site 1286640014529 Walker B; other site 1286640014530 D-loop; other site 1286640014531 H-loop/switch region; other site 1286640014532 TOBE domain; Region: TOBE; cl01440 1286640014533 TOBE domain; Region: TOBE_2; pfam08402 1286640014534 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640014535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640014536 dimer interface [polypeptide binding]; other site 1286640014537 conserved gate region; other site 1286640014538 putative PBP binding loops; other site 1286640014539 ABC-ATPase subunit interface; other site 1286640014540 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640014541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640014542 dimer interface [polypeptide binding]; other site 1286640014543 conserved gate region; other site 1286640014544 putative PBP binding loops; other site 1286640014545 ABC-ATPase subunit interface; other site 1286640014546 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640014547 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1286640014548 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286640014549 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 1286640014550 NAD(P) binding site [chemical binding]; other site 1286640014551 catalytic residues [active] 1286640014552 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1286640014553 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286640014554 substrate binding site [chemical binding]; other site 1286640014555 oxyanion hole (OAH) forming residues; other site 1286640014556 trimer interface [polypeptide binding]; other site 1286640014557 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1286640014558 Coenzyme A transferase; Region: CoA_trans; smart00882 1286640014559 Coenzyme A transferase; Region: CoA_trans; cl17247 1286640014560 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640014561 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640014562 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286640014563 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640014564 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640014565 DNA binding site [nucleotide binding] 1286640014566 domain linker motif; other site 1286640014567 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1286640014568 putative dimerization interface [polypeptide binding]; other site 1286640014569 putative ligand binding site [chemical binding]; other site 1286640014570 Protein of unknown function (DUF993); Region: DUF993; pfam06187 1286640014571 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1286640014572 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1286640014573 active site 1286640014574 Zn binding site [ion binding]; other site 1286640014575 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286640014576 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1286640014577 tartrate dehydrogenase; Region: TTC; TIGR02089 1286640014578 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1286640014579 active site 1286640014580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640014581 putative substrate translocation pore; other site 1286640014582 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1286640014583 oligomeric interface; other site 1286640014584 putative active site [active] 1286640014585 homodimer interface [polypeptide binding]; other site 1286640014586 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1286640014587 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1286640014588 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1286640014589 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1286640014590 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286640014591 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286640014592 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1286640014593 active site clefts [active] 1286640014594 zinc binding site [ion binding]; other site 1286640014595 dimer interface [polypeptide binding]; other site 1286640014596 pyridoxamine kinase; Validated; Region: PRK05756 1286640014597 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1286640014598 pyridoxal binding site [chemical binding]; other site 1286640014599 dimer interface [polypeptide binding]; other site 1286640014600 ATP binding site [chemical binding]; other site 1286640014601 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 1286640014602 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1286640014603 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1286640014604 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1286640014605 purine monophosphate binding site [chemical binding]; other site 1286640014606 dimer interface [polypeptide binding]; other site 1286640014607 putative catalytic residues [active] 1286640014608 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1286640014609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 1286640014610 NusB family; Region: NusB; pfam01029 1286640014611 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1286640014612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640014613 S-adenosylmethionine binding site [chemical binding]; other site 1286640014614 heat shock protein HtpX; Provisional; Region: PRK01345 1286640014615 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 1286640014616 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 1286640014617 acetyl-CoA synthetase; Provisional; Region: PRK00174 1286640014618 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1286640014619 active site 1286640014620 CoA binding site [chemical binding]; other site 1286640014621 acyl-activating enzyme (AAE) consensus motif; other site 1286640014622 AMP binding site [chemical binding]; other site 1286640014623 acetate binding site [chemical binding]; other site 1286640014624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 1286640014625 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1286640014626 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286640014627 acyl-activating enzyme (AAE) consensus motif; other site 1286640014628 AMP binding site [chemical binding]; other site 1286640014629 active site 1286640014630 CoA binding site [chemical binding]; other site 1286640014631 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1286640014632 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286640014633 catalytic residue [active] 1286640014634 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1286640014635 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1286640014636 HIGH motif; other site 1286640014637 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1286640014638 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1286640014639 active site 1286640014640 KMSKS motif; other site 1286640014641 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1286640014642 tRNA binding surface [nucleotide binding]; other site 1286640014643 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 1286640014644 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 1286640014645 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1286640014646 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1286640014647 ParB-like nuclease domain; Region: ParBc; pfam02195 1286640014648 KorB domain; Region: KorB; pfam08535 1286640014649 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1286640014650 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1286640014651 P-loop; other site 1286640014652 Magnesium ion binding site [ion binding]; other site 1286640014653 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1286640014654 Magnesium ion binding site [ion binding]; other site 1286640014655 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1286640014656 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1286640014657 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1286640014658 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1286640014659 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1286640014660 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1286640014661 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 1286640014662 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1286640014663 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1286640014664 G1 box; other site 1286640014665 GTP/Mg2+ binding site [chemical binding]; other site 1286640014666 Switch I region; other site 1286640014667 G2 box; other site 1286640014668 Switch II region; other site 1286640014669 G3 box; other site 1286640014670 G4 box; other site 1286640014671 G5 box; other site 1286640014672 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1286640014673 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1286640014674 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1286640014675 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1286640014676 RNA binding site [nucleotide binding]; other site 1286640014677 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1286640014678 multimer interface [polypeptide binding]; other site 1286640014679 Walker A motif; other site 1286640014680 ATP binding site [chemical binding]; other site 1286640014681 Walker B motif; other site 1286640014682 Predicted membrane protein [Function unknown]; Region: COG1981 1286640014683 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1286640014684 substrate binding site [chemical binding]; other site 1286640014685 active site 1286640014686 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640014687 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640014688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286640014689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640014690 putative PBP binding loops; other site 1286640014691 ABC-ATPase subunit interface; other site 1286640014692 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640014693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640014694 dimer interface [polypeptide binding]; other site 1286640014695 conserved gate region; other site 1286640014696 putative PBP binding loops; other site 1286640014697 ABC-ATPase subunit interface; other site 1286640014698 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1286640014699 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1286640014700 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1286640014701 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1286640014702 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640014703 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640014704 Walker A/P-loop; other site 1286640014705 ATP binding site [chemical binding]; other site 1286640014706 Q-loop/lid; other site 1286640014707 ABC transporter signature motif; other site 1286640014708 Walker B; other site 1286640014709 D-loop; other site 1286640014710 H-loop/switch region; other site 1286640014711 TOBE domain; Region: TOBE_2; pfam08402 1286640014712 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 1286640014713 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1286640014714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640014715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640014716 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1286640014717 putative effector binding pocket; other site 1286640014718 putative dimerization interface [polypeptide binding]; other site 1286640014719 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640014720 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1286640014721 putative C-terminal domain interface [polypeptide binding]; other site 1286640014722 putative GSH binding site (G-site) [chemical binding]; other site 1286640014723 putative dimer interface [polypeptide binding]; other site 1286640014724 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1286640014725 putative N-terminal domain interface [polypeptide binding]; other site 1286640014726 putative dimer interface [polypeptide binding]; other site 1286640014727 putative substrate binding pocket (H-site) [chemical binding]; other site 1286640014728 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576 1286640014729 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1286640014730 hydroperoxidase II; Provisional; Region: katE; PRK11249 1286640014731 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1286640014732 tetramer interface [polypeptide binding]; other site 1286640014733 heme binding pocket [chemical binding]; other site 1286640014734 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1286640014735 domain interactions; other site 1286640014736 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1286640014737 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1286640014738 active site 1286640014739 DNA binding site [nucleotide binding] 1286640014740 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1286640014741 DNA binding site [nucleotide binding] 1286640014742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640014743 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1286640014744 dimerization interface [polypeptide binding]; other site 1286640014745 substrate binding pocket [chemical binding]; other site 1286640014746 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1286640014747 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286640014748 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1286640014749 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1286640014750 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640014751 putative NAD(P) binding site [chemical binding]; other site 1286640014752 active site 1286640014753 putative substrate binding site [chemical binding]; other site 1286640014754 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 1286640014755 putative active site [active] 1286640014756 redox center [active] 1286640014757 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640014758 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640014759 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286640014760 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640014761 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640014762 DNA binding site [nucleotide binding] 1286640014763 domain linker motif; other site 1286640014764 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1286640014765 dimerization interface [polypeptide binding]; other site 1286640014766 ligand binding site [chemical binding]; other site 1286640014767 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640014768 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640014769 TM-ABC transporter signature motif; other site 1286640014770 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640014771 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640014772 TM-ABC transporter signature motif; other site 1286640014773 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640014774 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286640014775 Walker A/P-loop; other site 1286640014776 ATP binding site [chemical binding]; other site 1286640014777 Q-loop/lid; other site 1286640014778 ABC transporter signature motif; other site 1286640014779 Walker B; other site 1286640014780 D-loop; other site 1286640014781 H-loop/switch region; other site 1286640014782 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640014783 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 1286640014784 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286640014785 putative ligand binding site [chemical binding]; other site 1286640014786 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1286640014787 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1286640014788 E3 interaction surface; other site 1286640014789 lipoyl attachment site [posttranslational modification]; other site 1286640014790 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1286640014791 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1286640014792 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1286640014793 tetramer interface [polypeptide binding]; other site 1286640014794 TPP-binding site [chemical binding]; other site 1286640014795 heterodimer interface [polypeptide binding]; other site 1286640014796 phosphorylation loop region [posttranslational modification] 1286640014797 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1286640014798 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1286640014799 alpha subunit interface [polypeptide binding]; other site 1286640014800 TPP binding site [chemical binding]; other site 1286640014801 heterodimer interface [polypeptide binding]; other site 1286640014802 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286640014803 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640014804 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640014805 putative DNA binding site [nucleotide binding]; other site 1286640014806 putative Zn2+ binding site [ion binding]; other site 1286640014807 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640014808 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1286640014809 5-oxoprolinase; Region: PLN02666 1286640014810 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1286640014811 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1286640014812 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1286640014813 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1286640014814 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286640014815 RNA binding surface [nucleotide binding]; other site 1286640014816 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1286640014817 active site 1286640014818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1286640014819 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1286640014820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1286640014821 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1286640014822 active site 1286640014823 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1286640014824 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1286640014825 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1286640014826 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1286640014827 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286640014828 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1286640014829 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1286640014830 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1286640014831 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1286640014832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640014833 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1286640014834 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1286640014835 DctM-like transporters; Region: DctM; pfam06808 1286640014836 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1286640014837 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1286640014838 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1286640014839 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1286640014840 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1286640014841 shikimate binding site; other site 1286640014842 NAD(P) binding site [chemical binding]; other site 1286640014843 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286640014844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640014845 DNA-binding site [nucleotide binding]; DNA binding site 1286640014846 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640014847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640014848 homodimer interface [polypeptide binding]; other site 1286640014849 catalytic residue [active] 1286640014850 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286640014851 EamA-like transporter family; Region: EamA; pfam00892 1286640014852 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 1286640014853 HTH DNA binding domain; Region: HTH_13; pfam11972 1286640014854 replication initiation protein RepC; Provisional; Region: PRK13824 1286640014855 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1286640014856 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1286640014857 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 1286640014858 ParB-like nuclease domain; Region: ParB; smart00470 1286640014859 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 1286640014860 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1286640014861 P-loop; other site 1286640014862 Magnesium ion binding site [ion binding]; other site 1286640014863 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1286640014864 Magnesium ion binding site [ion binding]; other site 1286640014865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640014866 DNA-binding site [nucleotide binding]; DNA binding site 1286640014867 UTRA domain; Region: UTRA; pfam07702 1286640014868 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1286640014869 elongation factor G; Reviewed; Region: PRK12740 1286640014870 G1 box; other site 1286640014871 GTP/Mg2+ binding site [chemical binding]; other site 1286640014872 G2 box; other site 1286640014873 G3 box; other site 1286640014874 Switch II region; other site 1286640014875 G4 box; other site 1286640014876 G5 box; other site 1286640014877 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1286640014878 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1286640014879 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286640014880 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286640014881 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286640014882 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1286640014883 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1286640014884 conserved cys residue [active] 1286640014885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640014886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640014887 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1286640014888 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1286640014889 putative ligand binding residues [chemical binding]; other site 1286640014890 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286640014891 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286640014892 ABC-ATPase subunit interface; other site 1286640014893 dimer interface [polypeptide binding]; other site 1286640014894 putative PBP binding regions; other site 1286640014895 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1286640014896 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286640014897 Walker A/P-loop; other site 1286640014898 ATP binding site [chemical binding]; other site 1286640014899 Q-loop/lid; other site 1286640014900 ABC transporter signature motif; other site 1286640014901 Walker B; other site 1286640014902 D-loop; other site 1286640014903 H-loop/switch region; other site 1286640014904 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1286640014905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640014906 S-adenosylmethionine binding site [chemical binding]; other site 1286640014907 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1286640014908 MULE transposase domain; Region: MULE; pfam10551 1286640014909 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 1286640014910 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1286640014911 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1286640014912 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640014913 Winged helix-turn helix; Region: HTH_29; pfam13551 1286640014914 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1286640014915 trimer interface [polypeptide binding]; other site 1286640014916 putative Zn binding site [ion binding]; other site 1286640014917 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1286640014918 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1286640014919 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1286640014920 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1286640014921 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1286640014922 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1286640014923 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1286640014924 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286640014925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640014926 putative substrate translocation pore; other site 1286640014927 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640014928 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1286640014929 putative ligand binding site [chemical binding]; other site 1286640014930 short chain dehydrogenase; Provisional; Region: PRK06701 1286640014931 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1286640014932 NAD binding site [chemical binding]; other site 1286640014933 metal binding site [ion binding]; metal-binding site 1286640014934 active site 1286640014935 short chain dehydrogenase; Provisional; Region: PRK06139 1286640014936 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1286640014937 putative NAD(P) binding site [chemical binding]; other site 1286640014938 active site 1286640014939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1286640014940 Histidine kinase; Region: HisKA_3; pfam07730 1286640014941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640014942 ATP binding site [chemical binding]; other site 1286640014943 Mg2+ binding site [ion binding]; other site 1286640014944 G-X-G motif; other site 1286640014945 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640014946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640014947 active site 1286640014948 phosphorylation site [posttranslational modification] 1286640014949 intermolecular recognition site; other site 1286640014950 dimerization interface [polypeptide binding]; other site 1286640014951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640014952 DNA binding residues [nucleotide binding] 1286640014953 dimerization interface [polypeptide binding]; other site 1286640014954 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1286640014955 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1286640014956 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1286640014957 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1286640014958 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1286640014959 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1286640014960 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286640014961 NAD binding site [chemical binding]; other site 1286640014962 catalytic Zn binding site [ion binding]; other site 1286640014963 structural Zn binding site [ion binding]; other site 1286640014964 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 1286640014965 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1286640014966 active site 1286640014967 metal binding site [ion binding]; metal-binding site 1286640014968 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 1286640014969 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1286640014970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640014971 S-adenosylmethionine binding site [chemical binding]; other site 1286640014972 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1286640014973 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1286640014974 dinuclear metal binding motif [ion binding]; other site 1286640014975 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1286640014976 putative catalytic site [active] 1286640014977 putative metal binding site [ion binding]; other site 1286640014978 putative phosphate binding site [ion binding]; other site 1286640014979 Predicted integral membrane protein [Function unknown]; Region: COG0392 1286640014980 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1286640014981 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1286640014982 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1286640014983 putative active site [active] 1286640014984 putative active site [active] 1286640014985 catalytic site [active] 1286640014986 catalytic site [active] 1286640014987 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1286640014988 putative active site [active] 1286640014989 catalytic site [active] 1286640014990 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1286640014991 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1286640014992 PYR/PP interface [polypeptide binding]; other site 1286640014993 dimer interface [polypeptide binding]; other site 1286640014994 tetramer interface [polypeptide binding]; other site 1286640014995 TPP binding site [chemical binding]; other site 1286640014996 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286640014997 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1286640014998 TPP-binding site [chemical binding]; other site 1286640014999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4288 1286640015000 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1286640015001 FAD binding domain; Region: FAD_binding_4; pfam01565 1286640015002 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1286640015003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4288 1286640015004 trehalose synthase; Region: treS_nterm; TIGR02456 1286640015005 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1286640015006 active site 1286640015007 catalytic site [active] 1286640015008 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1286640015009 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 1286640015010 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1286640015011 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640015012 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1286640015013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640015014 Walker A motif; other site 1286640015015 ATP binding site [chemical binding]; other site 1286640015016 Walker B motif; other site 1286640015017 arginine finger; other site 1286640015018 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286640015019 SnoaL-like domain; Region: SnoaL_2; pfam12680 1286640015020 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1286640015021 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1286640015022 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286640015023 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640015024 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640015025 DNA-binding site [nucleotide binding]; DNA binding site 1286640015026 FCD domain; Region: FCD; pfam07729 1286640015027 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640015028 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640015029 DNA-binding site [nucleotide binding]; DNA binding site 1286640015030 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286640015031 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286640015032 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1286640015033 inhibitor site; inhibition site 1286640015034 active site 1286640015035 dimer interface [polypeptide binding]; other site 1286640015036 catalytic residue [active] 1286640015037 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640015038 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 1286640015039 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640015040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015041 dimer interface [polypeptide binding]; other site 1286640015042 conserved gate region; other site 1286640015043 putative PBP binding loops; other site 1286640015044 ABC-ATPase subunit interface; other site 1286640015045 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286640015046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015047 dimer interface [polypeptide binding]; other site 1286640015048 conserved gate region; other site 1286640015049 putative PBP binding loops; other site 1286640015050 ABC-ATPase subunit interface; other site 1286640015051 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1286640015052 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640015053 Walker A/P-loop; other site 1286640015054 ATP binding site [chemical binding]; other site 1286640015055 Q-loop/lid; other site 1286640015056 ABC transporter signature motif; other site 1286640015057 Walker B; other site 1286640015058 D-loop; other site 1286640015059 H-loop/switch region; other site 1286640015060 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640015061 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640015062 Walker A/P-loop; other site 1286640015063 ATP binding site [chemical binding]; other site 1286640015064 Q-loop/lid; other site 1286640015065 ABC transporter signature motif; other site 1286640015066 Walker B; other site 1286640015067 D-loop; other site 1286640015068 H-loop/switch region; other site 1286640015069 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640015070 EamA-like transporter family; Region: EamA; pfam00892 1286640015071 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1286640015072 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1286640015073 putative ligand binding site [chemical binding]; other site 1286640015074 NAD binding site [chemical binding]; other site 1286640015075 catalytic site [active] 1286640015076 hypothetical protein; Validated; Region: PRK08245 1286640015077 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 1286640015078 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1286640015079 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1286640015080 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1286640015081 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640015082 putative ADP-binding pocket [chemical binding]; other site 1286640015083 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286640015084 homotrimer interaction site [polypeptide binding]; other site 1286640015085 putative active site [active] 1286640015086 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1286640015087 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1286640015088 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1286640015089 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1286640015090 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640015091 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640015092 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1286640015093 putative dimerization interface [polypeptide binding]; other site 1286640015094 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1286640015095 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640015096 Walker A/P-loop; other site 1286640015097 ATP binding site [chemical binding]; other site 1286640015098 Q-loop/lid; other site 1286640015099 ABC transporter signature motif; other site 1286640015100 Walker B; other site 1286640015101 D-loop; other site 1286640015102 H-loop/switch region; other site 1286640015103 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640015104 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640015105 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1286640015106 TM-ABC transporter signature motif; other site 1286640015107 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640015108 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1286640015109 TM-ABC transporter signature motif; other site 1286640015110 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1286640015111 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1286640015112 putative ligand binding site [chemical binding]; other site 1286640015113 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1286640015114 cytosine deaminase; Provisional; Region: PRK05985 1286640015115 active site 1286640015116 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640015117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1286640015118 DNA-binding site [nucleotide binding]; DNA binding site 1286640015119 FCD domain; Region: FCD; pfam07729 1286640015120 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1286640015121 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1286640015122 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1286640015123 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640015124 catalytic loop [active] 1286640015125 iron binding site [ion binding]; other site 1286640015126 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1286640015127 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1286640015128 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1286640015129 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640015130 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1286640015131 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1286640015132 P-loop, Walker A motif; other site 1286640015133 Base recognition motif; other site 1286640015134 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1286640015135 xanthine permease; Region: pbuX; TIGR03173 1286640015136 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1286640015137 Flavoprotein; Region: Flavoprotein; pfam02441 1286640015138 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1286640015139 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1286640015140 active site 1286640015141 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1286640015142 active site 1286640015143 Predicted membrane protein [Function unknown]; Region: COG4329 1286640015144 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286640015145 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1286640015146 inhibitor site; inhibition site 1286640015147 active site 1286640015148 dimer interface [polypeptide binding]; other site 1286640015149 catalytic residue [active] 1286640015150 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1286640015151 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640015152 Walker A/P-loop; other site 1286640015153 ATP binding site [chemical binding]; other site 1286640015154 Q-loop/lid; other site 1286640015155 ABC transporter signature motif; other site 1286640015156 Walker B; other site 1286640015157 D-loop; other site 1286640015158 H-loop/switch region; other site 1286640015159 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640015160 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640015161 Walker A/P-loop; other site 1286640015162 ATP binding site [chemical binding]; other site 1286640015163 Q-loop/lid; other site 1286640015164 ABC transporter signature motif; other site 1286640015165 Walker B; other site 1286640015166 D-loop; other site 1286640015167 H-loop/switch region; other site 1286640015168 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640015169 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286640015170 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1286640015171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015172 dimer interface [polypeptide binding]; other site 1286640015173 conserved gate region; other site 1286640015174 putative PBP binding loops; other site 1286640015175 ABC-ATPase subunit interface; other site 1286640015176 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640015177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015178 dimer interface [polypeptide binding]; other site 1286640015179 conserved gate region; other site 1286640015180 putative PBP binding loops; other site 1286640015181 ABC-ATPase subunit interface; other site 1286640015182 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640015183 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 1286640015184 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1286640015185 BNR repeat-like domain; Region: BNR_2; pfam13088 1286640015186 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 1286640015187 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1286640015188 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1286640015189 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 1286640015190 putative active site [active] 1286640015191 metal binding site [ion binding]; metal-binding site 1286640015192 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640015193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640015194 DNA-binding site [nucleotide binding]; DNA binding site 1286640015195 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286640015196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1286640015197 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1286640015198 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1286640015199 active site 1286640015200 dimerization interface [polypeptide binding]; other site 1286640015201 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1286640015202 active site 1286640015203 catalytic residues [active] 1286640015204 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1286640015205 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1286640015206 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1286640015207 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1286640015208 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1286640015209 PhoU domain; Region: PhoU; pfam01895 1286640015210 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640015211 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640015212 DNA binding site [nucleotide binding] 1286640015213 domain linker motif; other site 1286640015214 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 1286640015215 putative dimerization interface [polypeptide binding]; other site 1286640015216 putative ligand binding site [chemical binding]; other site 1286640015217 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286640015218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015219 dimer interface [polypeptide binding]; other site 1286640015220 conserved gate region; other site 1286640015221 putative PBP binding loops; other site 1286640015222 ABC-ATPase subunit interface; other site 1286640015223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015224 dimer interface [polypeptide binding]; other site 1286640015225 conserved gate region; other site 1286640015226 putative PBP binding loops; other site 1286640015227 ABC-ATPase subunit interface; other site 1286640015228 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286640015229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640015230 Walker A/P-loop; other site 1286640015231 ATP binding site [chemical binding]; other site 1286640015232 Q-loop/lid; other site 1286640015233 ABC transporter signature motif; other site 1286640015234 Walker B; other site 1286640015235 D-loop; other site 1286640015236 H-loop/switch region; other site 1286640015237 TOBE domain; Region: TOBE_2; pfam08402 1286640015238 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286640015239 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1286640015240 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286640015241 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1286640015242 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1286640015243 active site 1286640015244 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1286640015245 active site 1286640015246 catalytic residues [active] 1286640015247 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286640015248 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286640015249 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640015250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640015251 active site 1286640015252 phosphorylation site [posttranslational modification] 1286640015253 intermolecular recognition site; other site 1286640015254 dimerization interface [polypeptide binding]; other site 1286640015255 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640015256 DNA binding residues [nucleotide binding] 1286640015257 dimerization interface [polypeptide binding]; other site 1286640015258 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1286640015259 FIST N domain; Region: FIST; pfam08495 1286640015260 FIST C domain; Region: FIST_C; pfam10442 1286640015261 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1286640015262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640015263 dimer interface [polypeptide binding]; other site 1286640015264 phosphorylation site [posttranslational modification] 1286640015265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640015266 ATP binding site [chemical binding]; other site 1286640015267 Mg2+ binding site [ion binding]; other site 1286640015268 G-X-G motif; other site 1286640015269 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640015270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640015271 active site 1286640015272 phosphorylation site [posttranslational modification] 1286640015273 intermolecular recognition site; other site 1286640015274 dimerization interface [polypeptide binding]; other site 1286640015275 Predicted secreted protein [Function unknown]; Region: COG5501 1286640015276 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 1286640015277 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 1286640015278 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286640015279 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1286640015280 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1286640015281 substrate binding site [chemical binding]; other site 1286640015282 catalytic Zn binding site [ion binding]; other site 1286640015283 NAD binding site [chemical binding]; other site 1286640015284 structural Zn binding site [ion binding]; other site 1286640015285 dimer interface [polypeptide binding]; other site 1286640015286 S-formylglutathione hydrolase; Region: PLN02442 1286640015287 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1286640015288 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1286640015289 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1286640015290 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 1286640015291 Trp docking motif [polypeptide binding]; other site 1286640015292 dimer interface [polypeptide binding]; other site 1286640015293 active site 1286640015294 small subunit binding site [polypeptide binding]; other site 1286640015295 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286640015296 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 1286640015297 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 1286640015298 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640015299 substrate binding pocket [chemical binding]; other site 1286640015300 membrane-bound complex binding site; other site 1286640015301 hinge residues; other site 1286640015302 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1286640015303 active site residue [active] 1286640015304 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 1286640015305 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1286640015306 ligand binding site [chemical binding]; other site 1286640015307 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1286640015308 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1286640015309 structural tetrad; other site 1286640015310 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1286640015311 NMT1/THI5 like; Region: NMT1; pfam09084 1286640015312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1286640015313 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286640015314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015315 dimer interface [polypeptide binding]; other site 1286640015316 conserved gate region; other site 1286640015317 putative PBP binding loops; other site 1286640015318 ABC-ATPase subunit interface; other site 1286640015319 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1286640015320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640015321 Walker A/P-loop; other site 1286640015322 ATP binding site [chemical binding]; other site 1286640015323 Q-loop/lid; other site 1286640015324 ABC transporter signature motif; other site 1286640015325 Walker B; other site 1286640015326 D-loop; other site 1286640015327 H-loop/switch region; other site 1286640015328 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1286640015329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640015330 Walker A/P-loop; other site 1286640015331 ATP binding site [chemical binding]; other site 1286640015332 Q-loop/lid; other site 1286640015333 ABC transporter signature motif; other site 1286640015334 Walker B; other site 1286640015335 D-loop; other site 1286640015336 H-loop/switch region; other site 1286640015337 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1286640015338 alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861 1286640015339 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 1286640015340 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1286640015341 putative catalytic residue [active] 1286640015342 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1286640015343 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1286640015344 substrate binding site [chemical binding]; other site 1286640015345 hexamer interface [polypeptide binding]; other site 1286640015346 metal binding site [ion binding]; metal-binding site 1286640015347 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 1286640015348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640015349 Walker A motif; other site 1286640015350 ATP binding site [chemical binding]; other site 1286640015351 Walker B motif; other site 1286640015352 arginine finger; other site 1286640015353 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 1286640015354 multimerization interface [polypeptide binding]; other site 1286640015355 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 1286640015356 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 1286640015357 homodimer interface [polypeptide binding]; other site 1286640015358 active site 1286640015359 heterodimer interface [polypeptide binding]; other site 1286640015360 catalytic residue [active] 1286640015361 metal binding site [ion binding]; metal-binding site 1286640015362 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1286640015363 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1286640015364 intersubunit interface [polypeptide binding]; other site 1286640015365 active site 1286640015366 zinc binding site [ion binding]; other site 1286640015367 Na+ binding site [ion binding]; other site 1286640015368 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1286640015369 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1286640015370 TPP-binding site [chemical binding]; other site 1286640015371 dimer interface [polypeptide binding]; other site 1286640015372 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1286640015373 PYR/PP interface [polypeptide binding]; other site 1286640015374 dimer interface [polypeptide binding]; other site 1286640015375 TPP binding site [chemical binding]; other site 1286640015376 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286640015377 phosphoribulokinase; Provisional; Region: PRK15453 1286640015378 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1286640015379 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1286640015380 AMP binding site [chemical binding]; other site 1286640015381 metal binding site [ion binding]; metal-binding site 1286640015382 active site 1286640015383 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640015384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640015385 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1286640015386 putative dimerization interface [polypeptide binding]; other site 1286640015387 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 1286640015388 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1286640015389 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1286640015390 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1286640015391 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 1286640015392 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1286640015393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286640015394 FeS/SAM binding site; other site 1286640015395 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1286640015396 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1286640015397 active site 1 [active] 1286640015398 dimer interface [polypeptide binding]; other site 1286640015399 hexamer interface [polypeptide binding]; other site 1286640015400 active site 2 [active] 1286640015401 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1286640015402 classical (c) SDRs; Region: SDR_c; cd05233 1286640015403 NAD(P) binding site [chemical binding]; other site 1286640015404 active site 1286640015405 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640015406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640015407 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1286640015408 putative effector binding pocket; other site 1286640015409 putative dimerization interface [polypeptide binding]; other site 1286640015410 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1286640015411 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1286640015412 potential catalytic triad [active] 1286640015413 conserved cys residue [active] 1286640015414 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1286640015415 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1286640015416 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1286640015417 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286640015418 catalytic residues [active] 1286640015419 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1286640015420 classical (c) SDRs; Region: SDR_c; cd05233 1286640015421 NAD(P) binding site [chemical binding]; other site 1286640015422 active site 1286640015423 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1286640015424 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1286640015425 conserved cys residue [active] 1286640015426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640015427 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286640015428 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286640015429 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1286640015430 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640015431 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1286640015432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1286640015433 dimer interface [polypeptide binding]; other site 1286640015434 phosphorylation site [posttranslational modification] 1286640015435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640015436 ATP binding site [chemical binding]; other site 1286640015437 Mg2+ binding site [ion binding]; other site 1286640015438 G-X-G motif; other site 1286640015439 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1286640015440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640015441 active site 1286640015442 phosphorylation site [posttranslational modification] 1286640015443 intermolecular recognition site; other site 1286640015444 dimerization interface [polypeptide binding]; other site 1286640015445 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640015446 DNA binding site [nucleotide binding] 1286640015447 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1286640015448 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286640015449 Cupin domain; Region: Cupin_2; pfam07883 1286640015450 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1286640015451 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1286640015452 BON domain; Region: BON; pfam04972 1286640015453 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1286640015454 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1286640015455 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640015456 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640015457 DNA binding site [nucleotide binding] 1286640015458 domain linker motif; other site 1286640015459 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1286640015460 dimerization interface [polypeptide binding]; other site 1286640015461 ligand binding site [chemical binding]; other site 1286640015462 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640015463 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640015464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286640015465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015466 ABC-ATPase subunit interface; other site 1286640015467 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640015468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015469 dimer interface [polypeptide binding]; other site 1286640015470 conserved gate region; other site 1286640015471 putative PBP binding loops; other site 1286640015472 ABC-ATPase subunit interface; other site 1286640015473 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 1286640015474 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640015475 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640015476 Walker A/P-loop; other site 1286640015477 ATP binding site [chemical binding]; other site 1286640015478 Q-loop/lid; other site 1286640015479 ABC transporter signature motif; other site 1286640015480 Walker B; other site 1286640015481 D-loop; other site 1286640015482 H-loop/switch region; other site 1286640015483 TOBE domain; Region: TOBE_2; pfam08402 1286640015484 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286640015485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640015486 S-adenosylmethionine binding site [chemical binding]; other site 1286640015487 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1286640015488 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640015489 NAD binding site [chemical binding]; other site 1286640015490 putative substrate binding site 2 [chemical binding]; other site 1286640015491 putative substrate binding site 1 [chemical binding]; other site 1286640015492 active site 1286640015493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1286640015494 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1286640015495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1286640015496 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1286640015497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1286640015498 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1286640015499 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1286640015500 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640015501 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 1286640015502 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640015503 NAD binding site [chemical binding]; other site 1286640015504 homotetramer interface [polypeptide binding]; other site 1286640015505 homodimer interface [polypeptide binding]; other site 1286640015506 active site 1286640015507 substrate binding site [chemical binding]; other site 1286640015508 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640015509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640015510 NAD(P) binding site [chemical binding]; other site 1286640015511 active site 1286640015512 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286640015513 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 1286640015514 putative NAD(P) binding site [chemical binding]; other site 1286640015515 catalytic Zn binding site [ion binding]; other site 1286640015516 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640015517 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640015518 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286640015519 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1286640015520 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1286640015521 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286640015522 catalytic core [active] 1286640015523 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1286640015524 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 1286640015525 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1286640015526 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1286640015527 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1286640015528 Predicted membrane protein [Function unknown]; Region: COG4420 1286640015529 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1286640015530 putative hydrophobic ligand binding site [chemical binding]; other site 1286640015531 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640015532 cyclase homology domain; Region: CHD; cd07302 1286640015533 nucleotidyl binding site; other site 1286640015534 metal binding site [ion binding]; metal-binding site 1286640015535 dimer interface [polypeptide binding]; other site 1286640015536 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640015537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640015538 DNA-binding site [nucleotide binding]; DNA binding site 1286640015539 FCD domain; Region: FCD; pfam07729 1286640015540 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286640015541 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1286640015542 inhibitor site; inhibition site 1286640015543 active site 1286640015544 dimer interface [polypeptide binding]; other site 1286640015545 catalytic residue [active] 1286640015546 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1286640015547 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1286640015548 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1286640015549 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1286640015550 dimer interface [polypeptide binding]; other site 1286640015551 NADP binding site [chemical binding]; other site 1286640015552 catalytic residues [active] 1286640015553 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286640015554 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640015555 substrate binding pocket [chemical binding]; other site 1286640015556 membrane-bound complex binding site; other site 1286640015557 hinge residues; other site 1286640015558 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640015559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015560 dimer interface [polypeptide binding]; other site 1286640015561 conserved gate region; other site 1286640015562 putative PBP binding loops; other site 1286640015563 ABC-ATPase subunit interface; other site 1286640015564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015565 dimer interface [polypeptide binding]; other site 1286640015566 conserved gate region; other site 1286640015567 putative PBP binding loops; other site 1286640015568 ABC-ATPase subunit interface; other site 1286640015569 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286640015570 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286640015571 Walker A/P-loop; other site 1286640015572 ATP binding site [chemical binding]; other site 1286640015573 Q-loop/lid; other site 1286640015574 ABC transporter signature motif; other site 1286640015575 Walker B; other site 1286640015576 D-loop; other site 1286640015577 H-loop/switch region; other site 1286640015578 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1286640015579 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1286640015580 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640015581 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 1286640015582 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1286640015583 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 1286640015584 substrate binding site [chemical binding]; other site 1286640015585 Protein of unknown function (DUF521); Region: DUF521; pfam04412 1286640015586 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 1286640015587 substrate binding site [chemical binding]; other site 1286640015588 ligand binding site [chemical binding]; other site 1286640015589 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 1286640015590 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1286640015591 OsmC-like protein; Region: OsmC; cl00767 1286640015592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640015593 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286640015594 putative substrate translocation pore; other site 1286640015595 Uncharacterized conserved protein [Function unknown]; Region: COG3246 1286640015596 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286640015597 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286640015598 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286640015599 putative active site [active] 1286640015600 hypothetical protein; Provisional; Region: PRK07483 1286640015601 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640015602 inhibitor-cofactor binding pocket; inhibition site 1286640015603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640015604 catalytic residue [active] 1286640015605 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1286640015606 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1286640015607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 1286640015608 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1286640015609 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1286640015610 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286640015611 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286640015612 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1286640015613 Walker A/P-loop; other site 1286640015614 ATP binding site [chemical binding]; other site 1286640015615 Q-loop/lid; other site 1286640015616 ABC transporter signature motif; other site 1286640015617 Walker B; other site 1286640015618 D-loop; other site 1286640015619 H-loop/switch region; other site 1286640015620 TOBE domain; Region: TOBE_2; pfam08402 1286640015621 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640015622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015623 dimer interface [polypeptide binding]; other site 1286640015624 conserved gate region; other site 1286640015625 putative PBP binding loops; other site 1286640015626 ABC-ATPase subunit interface; other site 1286640015627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286640015628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015629 ABC-ATPase subunit interface; other site 1286640015630 putative PBP binding loops; other site 1286640015631 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1286640015632 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286640015633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640015634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640015635 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640015636 dimerization interface [polypeptide binding]; other site 1286640015637 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1286640015638 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286640015639 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1286640015640 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1286640015641 active site 1286640015642 putative substrate binding pocket [chemical binding]; other site 1286640015643 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1286640015644 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640015645 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640015646 DNA binding site [nucleotide binding] 1286640015647 domain linker motif; other site 1286640015648 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 1286640015649 putative dimerization interface [polypeptide binding]; other site 1286640015650 putative ligand binding site [chemical binding]; other site 1286640015651 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 1286640015652 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 1286640015653 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 1286640015654 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1286640015655 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1286640015656 transcriptional regulator NanR; Provisional; Region: PRK03837 1286640015657 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640015658 DNA-binding site [nucleotide binding]; DNA binding site 1286640015659 FCD domain; Region: FCD; pfam07729 1286640015660 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1286640015661 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1286640015662 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1286640015663 DctM-like transporters; Region: DctM; pfam06808 1286640015664 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1286640015665 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286640015666 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1286640015667 inhibitor site; inhibition site 1286640015668 active site 1286640015669 dimer interface [polypeptide binding]; other site 1286640015670 catalytic residue [active] 1286640015671 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1286640015672 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1286640015673 inhibitor site; inhibition site 1286640015674 active site 1286640015675 dimer interface [polypeptide binding]; other site 1286640015676 catalytic residue [active] 1286640015677 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640015678 cyclase homology domain; Region: CHD; cd07302 1286640015679 nucleotidyl binding site; other site 1286640015680 metal binding site [ion binding]; metal-binding site 1286640015681 dimer interface [polypeptide binding]; other site 1286640015682 Predicted integral membrane protein [Function unknown]; Region: COG5616 1286640015683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640015684 binding surface 1286640015685 TPR motif; other site 1286640015686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640015687 TPR motif; other site 1286640015688 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1286640015689 binding surface 1286640015690 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1286640015691 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1286640015692 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1286640015693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1286640015694 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1286640015695 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1286640015696 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640015697 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640015698 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1286640015699 DAK2 domain; Region: Dak2; cl03685 1286640015700 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286640015701 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640015702 DNA binding residues [nucleotide binding] 1286640015703 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286640015704 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1286640015705 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1286640015706 DAK2 domain; Region: Dak2; pfam02734 1286640015707 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1286640015708 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1286640015709 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640015710 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640015711 TM-ABC transporter signature motif; other site 1286640015712 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1286640015713 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286640015714 ligand binding site [chemical binding]; other site 1286640015715 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640015716 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640015717 Walker A/P-loop; other site 1286640015718 ATP binding site [chemical binding]; other site 1286640015719 Q-loop/lid; other site 1286640015720 ABC transporter signature motif; other site 1286640015721 Walker B; other site 1286640015722 D-loop; other site 1286640015723 H-loop/switch region; other site 1286640015724 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640015725 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640015726 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640015727 TM-ABC transporter signature motif; other site 1286640015728 Predicted flavoproteins [General function prediction only]; Region: COG2081 1286640015729 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640015730 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1286640015731 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1286640015732 DctM-like transporters; Region: DctM; pfam06808 1286640015733 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1286640015734 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1286640015735 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640015736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640015737 DNA-binding site [nucleotide binding]; DNA binding site 1286640015738 FCD domain; Region: FCD; pfam07729 1286640015739 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640015740 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640015741 DNA binding site [nucleotide binding] 1286640015742 domain linker motif; other site 1286640015743 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1286640015744 ligand binding site [chemical binding]; other site 1286640015745 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640015746 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1286640015747 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640015748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015749 dimer interface [polypeptide binding]; other site 1286640015750 conserved gate region; other site 1286640015751 putative PBP binding loops; other site 1286640015752 ABC-ATPase subunit interface; other site 1286640015753 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640015754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015755 dimer interface [polypeptide binding]; other site 1286640015756 conserved gate region; other site 1286640015757 putative PBP binding loops; other site 1286640015758 ABC-ATPase subunit interface; other site 1286640015759 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640015760 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640015761 Walker A/P-loop; other site 1286640015762 ATP binding site [chemical binding]; other site 1286640015763 Q-loop/lid; other site 1286640015764 ABC transporter signature motif; other site 1286640015765 Walker B; other site 1286640015766 D-loop; other site 1286640015767 H-loop/switch region; other site 1286640015768 TOBE domain; Region: TOBE_2; pfam08402 1286640015769 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 1286640015770 conserved cys residue [active] 1286640015771 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640015772 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640015773 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286640015774 SPW repeat; Region: SPW; pfam03779 1286640015775 SPW repeat; Region: SPW; pfam03779 1286640015776 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1286640015777 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1286640015778 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1286640015779 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1286640015780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 1286640015781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640015782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640015783 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286640015784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640015785 putative substrate translocation pore; other site 1286640015786 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1286640015787 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1286640015788 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640015789 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640015790 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1286640015791 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640015792 catalytic loop [active] 1286640015793 iron binding site [ion binding]; other site 1286640015794 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1286640015795 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1286640015796 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286640015797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640015798 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1286640015799 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286640015800 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640015801 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640015802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640015803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640015804 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1286640015805 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1286640015806 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286640015807 ligand binding site [chemical binding]; other site 1286640015808 dimerization interface [polypeptide binding]; other site 1286640015809 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5618 1286640015810 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640015811 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640015812 Walker A/P-loop; other site 1286640015813 ATP binding site [chemical binding]; other site 1286640015814 Q-loop/lid; other site 1286640015815 ABC transporter signature motif; other site 1286640015816 Walker B; other site 1286640015817 D-loop; other site 1286640015818 H-loop/switch region; other site 1286640015819 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640015820 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640015821 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640015822 TM-ABC transporter signature motif; other site 1286640015823 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640015824 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640015825 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286640015826 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1286640015827 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286640015828 dimerization interface [polypeptide binding]; other site 1286640015829 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1286640015830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640015831 dimer interface [polypeptide binding]; other site 1286640015832 phosphorylation site [posttranslational modification] 1286640015833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640015834 ATP binding site [chemical binding]; other site 1286640015835 Mg2+ binding site [ion binding]; other site 1286640015836 G-X-G motif; other site 1286640015837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640015838 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640015839 active site 1286640015840 phosphorylation site [posttranslational modification] 1286640015841 intermolecular recognition site; other site 1286640015842 dimerization interface [polypeptide binding]; other site 1286640015843 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1286640015844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640015845 active site 1286640015846 phosphorylation site [posttranslational modification] 1286640015847 intermolecular recognition site; other site 1286640015848 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640015849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640015850 active site 1286640015851 phosphorylation site [posttranslational modification] 1286640015852 intermolecular recognition site; other site 1286640015853 dimerization interface [polypeptide binding]; other site 1286640015854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640015855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640015856 phosphorylation site [posttranslational modification] 1286640015857 dimer interface [polypeptide binding]; other site 1286640015858 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640015859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640015860 active site 1286640015861 phosphorylation site [posttranslational modification] 1286640015862 intermolecular recognition site; other site 1286640015863 dimerization interface [polypeptide binding]; other site 1286640015864 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1286640015865 cyclase homology domain; Region: CHD; cd07302 1286640015866 nucleotidyl binding site; other site 1286640015867 metal binding site [ion binding]; metal-binding site 1286640015868 dimer interface [polypeptide binding]; other site 1286640015869 Predicted periplasmic protein [Function unknown]; Region: COG3904 1286640015870 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1286640015871 Ion channel; Region: Ion_trans_2; pfam07885 1286640015872 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1286640015873 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 1286640015874 active site 1286640015875 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286640015876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640015877 Walker A/P-loop; other site 1286640015878 ATP binding site [chemical binding]; other site 1286640015879 Q-loop/lid; other site 1286640015880 ABC transporter signature motif; other site 1286640015881 Walker B; other site 1286640015882 D-loop; other site 1286640015883 H-loop/switch region; other site 1286640015884 TOBE domain; Region: TOBE_2; pfam08402 1286640015885 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286640015886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015887 dimer interface [polypeptide binding]; other site 1286640015888 conserved gate region; other site 1286640015889 putative PBP binding loops; other site 1286640015890 ABC-ATPase subunit interface; other site 1286640015891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015892 dimer interface [polypeptide binding]; other site 1286640015893 conserved gate region; other site 1286640015894 putative PBP binding loops; other site 1286640015895 ABC-ATPase subunit interface; other site 1286640015896 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1286640015897 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286640015898 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640015899 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640015900 DNA binding site [nucleotide binding] 1286640015901 domain linker motif; other site 1286640015902 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 1286640015903 putative dimerization interface [polypeptide binding]; other site 1286640015904 putative ligand binding site [chemical binding]; other site 1286640015905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640015906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640015907 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286640015908 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640015909 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1286640015910 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286640015911 FtsX-like permease family; Region: FtsX; pfam02687 1286640015912 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286640015913 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286640015914 Walker A/P-loop; other site 1286640015915 ATP binding site [chemical binding]; other site 1286640015916 Q-loop/lid; other site 1286640015917 ABC transporter signature motif; other site 1286640015918 Walker B; other site 1286640015919 D-loop; other site 1286640015920 H-loop/switch region; other site 1286640015921 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1286640015922 DctM-like transporters; Region: DctM; pfam06808 1286640015923 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1286640015924 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1286640015925 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1286640015926 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1286640015927 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640015928 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640015929 DNA-binding site [nucleotide binding]; DNA binding site 1286640015930 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286640015931 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286640015932 homotrimer interaction site [polypeptide binding]; other site 1286640015933 putative active site [active] 1286640015934 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286640015935 homotrimer interaction site [polypeptide binding]; other site 1286640015936 putative active site [active] 1286640015937 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286640015938 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1286640015939 tetramerization interface [polypeptide binding]; other site 1286640015940 NAD(P) binding site [chemical binding]; other site 1286640015941 catalytic residues [active] 1286640015942 aminotransferase; Provisional; Region: PRK06105 1286640015943 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640015944 inhibitor-cofactor binding pocket; inhibition site 1286640015945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640015946 catalytic residue [active] 1286640015947 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286640015948 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1286640015949 Walker A/P-loop; other site 1286640015950 ATP binding site [chemical binding]; other site 1286640015951 Q-loop/lid; other site 1286640015952 ABC transporter signature motif; other site 1286640015953 Walker B; other site 1286640015954 D-loop; other site 1286640015955 H-loop/switch region; other site 1286640015956 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640015957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015958 dimer interface [polypeptide binding]; other site 1286640015959 conserved gate region; other site 1286640015960 putative PBP binding loops; other site 1286640015961 ABC-ATPase subunit interface; other site 1286640015962 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1286640015963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286640015964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640015965 dimer interface [polypeptide binding]; other site 1286640015966 putative PBP binding loops; other site 1286640015967 ABC-ATPase subunit interface; other site 1286640015968 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1286640015969 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1286640015970 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 1286640015971 active site 1286640015972 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286640015973 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1286640015974 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286640015975 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 1286640015976 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1286640015977 NAD(P) binding site [chemical binding]; other site 1286640015978 GAF domain; Region: GAF; pfam01590 1286640015979 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1286640015980 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286640015981 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640015982 metal binding site [ion binding]; metal-binding site 1286640015983 active site 1286640015984 I-site; other site 1286640015985 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1286640015986 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640015987 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1286640015988 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1286640015989 DXD motif; other site 1286640015990 transcriptional regulator NanR; Provisional; Region: PRK03837 1286640015991 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640015992 DNA-binding site [nucleotide binding]; DNA binding site 1286640015993 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 1286640015994 FCD domain; Region: FCD; pfam07729 1286640015995 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 1286640015996 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 1286640015997 dimer interface [polypeptide binding]; other site 1286640015998 active site 1286640015999 catalytic residue [active] 1286640016000 metal binding site [ion binding]; metal-binding site 1286640016001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1286640016002 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1286640016003 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1286640016004 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640016005 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1286640016006 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1286640016007 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1286640016008 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640016009 catalytic loop [active] 1286640016010 iron binding site [ion binding]; other site 1286640016011 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1286640016012 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1286640016013 putative active site [active] 1286640016014 putative metal binding site [ion binding]; other site 1286640016015 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1286640016016 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286640016017 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286640016018 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1286640016019 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1286640016020 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640016021 catalytic loop [active] 1286640016022 iron binding site [ion binding]; other site 1286640016023 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1286640016024 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1286640016025 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640016026 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1286640016027 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640016028 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640016029 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640016030 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640016031 DNA binding residues [nucleotide binding] 1286640016032 dimerization interface [polypeptide binding]; other site 1286640016033 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1286640016034 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1286640016035 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1286640016036 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1286640016037 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1286640016038 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 1286640016039 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 1286640016040 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1286640016041 classical (c) SDRs; Region: SDR_c; cd05233 1286640016042 NAD(P) binding site [chemical binding]; other site 1286640016043 active site 1286640016044 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1286640016045 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1286640016046 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1286640016047 Predicted integral membrane protein [Function unknown]; Region: COG5528 1286640016048 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1286640016049 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1286640016050 putative NAD(P) binding site [chemical binding]; other site 1286640016051 active site 1286640016052 DoxX-like family; Region: DoxX_3; pfam13781 1286640016053 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286640016054 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640016055 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1286640016056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640016057 dimer interface [polypeptide binding]; other site 1286640016058 conserved gate region; other site 1286640016059 putative PBP binding loops; other site 1286640016060 ABC-ATPase subunit interface; other site 1286640016061 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640016062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640016063 dimer interface [polypeptide binding]; other site 1286640016064 conserved gate region; other site 1286640016065 ABC-ATPase subunit interface; other site 1286640016066 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640016067 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640016068 Walker A/P-loop; other site 1286640016069 ATP binding site [chemical binding]; other site 1286640016070 Q-loop/lid; other site 1286640016071 ABC transporter signature motif; other site 1286640016072 Walker B; other site 1286640016073 D-loop; other site 1286640016074 H-loop/switch region; other site 1286640016075 TOBE domain; Region: TOBE_2; pfam08402 1286640016076 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1286640016077 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1286640016078 putative C-terminal domain interface [polypeptide binding]; other site 1286640016079 putative GSH binding site (G-site) [chemical binding]; other site 1286640016080 putative dimer interface [polypeptide binding]; other site 1286640016081 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1286640016082 dimer interface [polypeptide binding]; other site 1286640016083 N-terminal domain interface [polypeptide binding]; other site 1286640016084 putative substrate binding pocket (H-site) [chemical binding]; other site 1286640016085 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1286640016086 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286640016087 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1286640016088 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1286640016089 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 1286640016090 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286640016091 putative NAD(P) binding site [chemical binding]; other site 1286640016092 hypothetical protein; Provisional; Region: PRK07482 1286640016093 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640016094 inhibitor-cofactor binding pocket; inhibition site 1286640016095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640016096 catalytic residue [active] 1286640016097 succinic semialdehyde dehydrogenase; Region: PLN02278 1286640016098 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1286640016099 tetramerization interface [polypeptide binding]; other site 1286640016100 NAD(P) binding site [chemical binding]; other site 1286640016101 catalytic residues [active] 1286640016102 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640016103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640016104 putative DNA binding site [nucleotide binding]; other site 1286640016105 putative Zn2+ binding site [ion binding]; other site 1286640016106 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640016107 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286640016108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640016109 DNA-binding site [nucleotide binding]; DNA binding site 1286640016110 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640016111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640016112 homodimer interface [polypeptide binding]; other site 1286640016113 catalytic residue [active] 1286640016114 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 1286640016115 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286640016116 Walker A/P-loop; other site 1286640016117 ATP binding site [chemical binding]; other site 1286640016118 Q-loop/lid; other site 1286640016119 ABC transporter signature motif; other site 1286640016120 Walker B; other site 1286640016121 D-loop; other site 1286640016122 H-loop/switch region; other site 1286640016123 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 1286640016124 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640016125 substrate binding pocket [chemical binding]; other site 1286640016126 membrane-bound complex binding site; other site 1286640016127 hinge residues; other site 1286640016128 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640016129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640016130 dimer interface [polypeptide binding]; other site 1286640016131 conserved gate region; other site 1286640016132 putative PBP binding loops; other site 1286640016133 ABC-ATPase subunit interface; other site 1286640016134 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640016135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640016136 dimer interface [polypeptide binding]; other site 1286640016137 conserved gate region; other site 1286640016138 putative PBP binding loops; other site 1286640016139 ABC-ATPase subunit interface; other site 1286640016140 ectoine utilization protein EutA; Region: ectoine_eutA; TIGR02990 1286640016141 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1286640016142 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1286640016143 tetramer interface [polypeptide binding]; other site 1286640016144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640016145 catalytic residue [active] 1286640016146 ectoine utilization protein EutC; Validated; Region: PRK08291 1286640016147 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1286640016148 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 1286640016149 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1286640016150 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1286640016151 active site 1286640016152 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 1286640016153 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 1286640016154 putative active site [active] 1286640016155 Zn binding site [ion binding]; other site 1286640016156 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1286640016157 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640016158 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640016159 DNA-binding site [nucleotide binding]; DNA binding site 1286640016160 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1286640016161 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1286640016162 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1286640016163 DctM-like transporters; Region: DctM; pfam06808 1286640016164 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1286640016165 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1286640016166 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1286640016167 putative NAD(P) binding site [chemical binding]; other site 1286640016168 catalytic Zn binding site [ion binding]; other site 1286640016169 mannonate dehydratase; Provisional; Region: PRK03906 1286640016170 mannonate dehydratase; Region: uxuA; TIGR00695 1286640016171 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286640016172 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640016173 metal binding site [ion binding]; metal-binding site 1286640016174 active site 1286640016175 I-site; other site 1286640016176 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640016177 Uncharacterized conserved protein [Function unknown]; Region: COG5439 1286640016178 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1286640016179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640016180 S-adenosylmethionine binding site [chemical binding]; other site 1286640016181 Cache domain; Region: Cache_1; pfam02743 1286640016182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286640016183 dimerization interface [polypeptide binding]; other site 1286640016184 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1286640016185 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1286640016186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 1286640016187 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1286640016188 anti sigma factor interaction site; other site 1286640016189 regulatory phosphorylation site [posttranslational modification]; other site 1286640016190 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1286640016191 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1286640016192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640016193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640016194 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1286640016195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640016196 NAD(P) binding site [chemical binding]; other site 1286640016197 active site 1286640016198 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640016199 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640016200 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640016201 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1286640016202 NAD binding site [chemical binding]; other site 1286640016203 putative substrate binding site 2 [chemical binding]; other site 1286640016204 putative substrate binding site 1 [chemical binding]; other site 1286640016205 active site 1286640016206 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1286640016207 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1286640016208 NAD binding site [chemical binding]; other site 1286640016209 homodimer interface [polypeptide binding]; other site 1286640016210 active site 1286640016211 substrate binding site [chemical binding]; other site 1286640016212 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1286640016213 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286640016214 active site 1286640016215 Cellulose synthase-like protein; Region: PLN02893 1286640016216 Protein of unknown function (DUF995); Region: DUF995; pfam06191 1286640016217 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1286640016218 Protein of unknown function (DUF995); Region: DUF995; pfam06191 1286640016219 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286640016220 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286640016221 nucleotide binding site [chemical binding]; other site 1286640016222 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1286640016223 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1286640016224 putative oligomer interface [polypeptide binding]; other site 1286640016225 putative active site [active] 1286640016226 metal binding site [ion binding]; metal-binding site 1286640016227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1286640016228 Histidine kinase; Region: HisKA_3; pfam07730 1286640016229 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640016230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640016231 active site 1286640016232 phosphorylation site [posttranslational modification] 1286640016233 intermolecular recognition site; other site 1286640016234 dimerization interface [polypeptide binding]; other site 1286640016235 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640016236 DNA binding residues [nucleotide binding] 1286640016237 dimerization interface [polypeptide binding]; other site 1286640016238 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1286640016239 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1286640016240 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 1286640016241 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1286640016242 dimer interface [polypeptide binding]; other site 1286640016243 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640016244 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1286640016245 peptide binding site [polypeptide binding]; other site 1286640016246 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640016247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640016248 dimer interface [polypeptide binding]; other site 1286640016249 conserved gate region; other site 1286640016250 putative PBP binding loops; other site 1286640016251 ABC-ATPase subunit interface; other site 1286640016252 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1286640016253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640016254 dimer interface [polypeptide binding]; other site 1286640016255 conserved gate region; other site 1286640016256 putative PBP binding loops; other site 1286640016257 ABC-ATPase subunit interface; other site 1286640016258 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1286640016259 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640016260 Walker A/P-loop; other site 1286640016261 ATP binding site [chemical binding]; other site 1286640016262 Q-loop/lid; other site 1286640016263 ABC transporter signature motif; other site 1286640016264 Walker B; other site 1286640016265 D-loop; other site 1286640016266 H-loop/switch region; other site 1286640016267 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1286640016268 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1286640016269 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640016270 Walker A/P-loop; other site 1286640016271 ATP binding site [chemical binding]; other site 1286640016272 Q-loop/lid; other site 1286640016273 ABC transporter signature motif; other site 1286640016274 Walker B; other site 1286640016275 D-loop; other site 1286640016276 H-loop/switch region; other site 1286640016277 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640016278 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640016279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640016280 DNA-binding site [nucleotide binding]; DNA binding site 1286640016281 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286640016282 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1286640016283 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1286640016284 active site 1286640016285 dimer interface [polypeptide binding]; other site 1286640016286 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1286640016287 Ligand Binding Site [chemical binding]; other site 1286640016288 Molecular Tunnel; other site 1286640016289 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1286640016290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640016291 Coenzyme A binding pocket [chemical binding]; other site 1286640016292 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 1286640016293 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640016294 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1286640016295 dimerization interface [polypeptide binding]; other site 1286640016296 ligand binding site [chemical binding]; other site 1286640016297 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1286640016298 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286640016299 ligand binding site [chemical binding]; other site 1286640016300 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640016301 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640016302 Walker A/P-loop; other site 1286640016303 ATP binding site [chemical binding]; other site 1286640016304 Q-loop/lid; other site 1286640016305 ABC transporter signature motif; other site 1286640016306 Walker B; other site 1286640016307 D-loop; other site 1286640016308 H-loop/switch region; other site 1286640016309 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640016310 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640016311 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640016312 TM-ABC transporter signature motif; other site 1286640016313 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640016314 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640016315 TM-ABC transporter signature motif; other site 1286640016316 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286640016317 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1286640016318 Metal-binding active site; metal-binding site 1286640016319 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1286640016320 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 1286640016321 N- and C-terminal domain interface [polypeptide binding]; other site 1286640016322 putative active site [active] 1286640016323 putative MgATP binding site [chemical binding]; other site 1286640016324 putative catalytic site [active] 1286640016325 metal binding site [ion binding]; metal-binding site 1286640016326 putative carbohydrate binding site [chemical binding]; other site 1286640016327 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1286640016328 intersubunit interface [polypeptide binding]; other site 1286640016329 active site 1286640016330 Zn2+ binding site [ion binding]; other site 1286640016331 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 1286640016332 Isochorismatase family; Region: Isochorismatase; pfam00857 1286640016333 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1286640016334 catalytic triad [active] 1286640016335 conserved cis-peptide bond; other site 1286640016336 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1286640016337 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1286640016338 NADP binding site [chemical binding]; other site 1286640016339 active site 1286640016340 steroid binding site; other site 1286640016341 short chain dehydrogenase; Provisional; Region: PRK12937 1286640016342 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1286640016343 NADP binding site [chemical binding]; other site 1286640016344 homodimer interface [polypeptide binding]; other site 1286640016345 active site 1286640016346 substrate binding site [chemical binding]; other site 1286640016347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640016348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640016349 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1286640016350 putative effector binding pocket; other site 1286640016351 putative dimerization interface [polypeptide binding]; other site 1286640016352 TPR repeat; Region: TPR_11; pfam13414 1286640016353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1286640016354 TPR motif; other site 1286640016355 binding surface 1286640016356 choline dehydrogenase; Validated; Region: PRK02106 1286640016357 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1286640016358 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1286640016359 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1286640016360 putative N- and C-terminal domain interface [polypeptide binding]; other site 1286640016361 putative active site [active] 1286640016362 MgATP binding site [chemical binding]; other site 1286640016363 catalytic site [active] 1286640016364 metal binding site [ion binding]; metal-binding site 1286640016365 putative xylulose binding site [chemical binding]; other site 1286640016366 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286640016367 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1286640016368 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1286640016369 putative active site; other site 1286640016370 catalytic residue [active] 1286640016371 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1286640016372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286640016373 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640016374 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640016375 active site 1286640016376 catalytic tetrad [active] 1286640016377 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286640016378 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640016379 DNA binding residues [nucleotide binding] 1286640016380 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286640016381 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640016382 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640016383 TM-ABC transporter signature motif; other site 1286640016384 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640016385 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640016386 Walker A/P-loop; other site 1286640016387 ATP binding site [chemical binding]; other site 1286640016388 Q-loop/lid; other site 1286640016389 ABC transporter signature motif; other site 1286640016390 Walker B; other site 1286640016391 D-loop; other site 1286640016392 H-loop/switch region; other site 1286640016393 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640016394 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640016395 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1286640016396 ligand binding site [chemical binding]; other site 1286640016397 Phosphotransferase enzyme family; Region: APH; pfam01636 1286640016398 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1286640016399 active site 1286640016400 ATP binding site [chemical binding]; other site 1286640016401 substrate binding site [chemical binding]; other site 1286640016402 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640016403 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640016404 TM-ABC transporter signature motif; other site 1286640016405 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1286640016406 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640016407 Walker A/P-loop; other site 1286640016408 ATP binding site [chemical binding]; other site 1286640016409 Q-loop/lid; other site 1286640016410 ABC transporter signature motif; other site 1286640016411 Walker B; other site 1286640016412 D-loop; other site 1286640016413 H-loop/switch region; other site 1286640016414 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640016415 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1286640016416 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1286640016417 ligand binding site [chemical binding]; other site 1286640016418 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640016419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640016420 DNA-binding site [nucleotide binding]; DNA binding site 1286640016421 FCD domain; Region: FCD; pfam07729 1286640016422 galactonate dehydratase; Provisional; Region: PRK14017 1286640016423 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1286640016424 putative active site pocket [active] 1286640016425 putative metal binding site [ion binding]; other site 1286640016426 short chain dehydrogenase; Provisional; Region: PRK07063 1286640016427 classical (c) SDRs; Region: SDR_c; cd05233 1286640016428 NAD(P) binding site [chemical binding]; other site 1286640016429 active site 1286640016430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640016431 Coenzyme A binding pocket [chemical binding]; other site 1286640016432 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1286640016433 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1286640016434 putative active site [active] 1286640016435 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1286640016436 CheB methylesterase; Region: CheB_methylest; pfam01339 1286640016437 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1286640016438 CheB methylesterase; Region: CheB_methylest; pfam01339 1286640016439 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1286640016440 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1286640016441 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1286640016442 PAS domain; Region: PAS_10; pfam13596 1286640016443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640016444 putative active site [active] 1286640016445 heme pocket [chemical binding]; other site 1286640016446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640016447 PAS domain; Region: PAS_9; pfam13426 1286640016448 putative active site [active] 1286640016449 heme pocket [chemical binding]; other site 1286640016450 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1286640016451 HWE histidine kinase; Region: HWE_HK; pfam07536 1286640016452 response regulator; Provisional; Region: PRK13435 1286640016453 Predicted chitinase [General function prediction only]; Region: COG3179 1286640016454 catalytic residue [active] 1286640016455 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640016456 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 1286640016457 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1286640016458 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286640016459 PRC-barrel domain; Region: PRC; pfam05239 1286640016460 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286640016461 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640016462 metal binding site [ion binding]; metal-binding site 1286640016463 active site 1286640016464 I-site; other site 1286640016465 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640016466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640016467 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 1286640016468 hypothetical protein; Provisional; Region: PRK05409 1286640016469 Predicted integral membrane protein [Function unknown]; Region: COG5572 1286640016470 RNA polymerase sigma factor; Provisional; Region: PRK12512 1286640016471 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286640016472 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640016473 DNA binding residues [nucleotide binding] 1286640016474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944 1286640016475 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286640016476 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286640016477 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1286640016478 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1286640016479 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 1286640016480 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1286640016481 putative ligand binding site [chemical binding]; other site 1286640016482 putative NAD binding site [chemical binding]; other site 1286640016483 catalytic site [active] 1286640016484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289 1286640016485 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640016486 DNA binding site [nucleotide binding] 1286640016487 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640016488 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1286640016489 ligand binding site [chemical binding]; other site 1286640016490 dimerization interface [polypeptide binding]; other site 1286640016491 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640016492 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640016493 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640016494 cyclase homology domain; Region: CHD; cd07302 1286640016495 nucleotidyl binding site; other site 1286640016496 metal binding site [ion binding]; metal-binding site 1286640016497 dimer interface [polypeptide binding]; other site 1286640016498 Predicted integral membrane protein [Function unknown]; Region: COG5616 1286640016499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640016500 TPR motif; other site 1286640016501 TPR repeat; Region: TPR_11; pfam13414 1286640016502 binding surface 1286640016503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640016504 binding surface 1286640016505 TPR motif; other site 1286640016506 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1286640016507 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1286640016508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1286640016509 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1286640016510 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1286640016511 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1286640016512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1286640016513 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1286640016514 Transposase; Region: HTH_Tnp_1; pfam01527 1286640016515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286640016516 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1286640016517 Transcriptional activator, adenine-specific DNA methyltransferase [Signal transduction mechanisms / Transcription]; Region: IME4; COG4725 1286640016518 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1286640016519 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1286640016520 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1286640016521 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286640016522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4333 1286640016523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1286640016524 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286640016525 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286640016526 ligand binding site [chemical binding]; other site 1286640016527 flexible hinge region; other site 1286640016528 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1286640016529 dimer interface [polypeptide binding]; other site 1286640016530 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286640016531 metal-binding site [ion binding] 1286640016532 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 1286640016533 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 1286640016534 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286640016535 Glycosyltransferase family 92; Region: Glyco_transf_92; pfam01697 1286640016536 active site 1286640016537 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286640016538 active site 1286640016539 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1286640016540 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1286640016541 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1286640016542 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1286640016543 putative active site [active] 1286640016544 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1286640016545 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1286640016546 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1286640016547 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1286640016548 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286640016549 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640016550 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1286640016551 Walker A/P-loop; other site 1286640016552 ATP binding site [chemical binding]; other site 1286640016553 Q-loop/lid; other site 1286640016554 ABC transporter signature motif; other site 1286640016555 Walker B; other site 1286640016556 D-loop; other site 1286640016557 H-loop/switch region; other site 1286640016558 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1286640016559 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1286640016560 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1286640016561 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1286640016562 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1286640016563 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640016564 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640016565 DNA binding site [nucleotide binding] 1286640016566 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1286640016567 putative ligand binding site [chemical binding]; other site 1286640016568 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1286640016569 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 1286640016570 putative di-iron ligands [ion binding]; other site 1286640016571 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1286640016572 [2Fe-2S] cluster binding site [ion binding]; other site 1286640016573 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1286640016574 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640016575 Ketopantoate hydroxymethyltransferase [Coenzyme metabolism]; Region: PanB; COG0413 1286640016576 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1286640016577 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1286640016578 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1286640016579 Predicted glycosyltransferase involved in capsule biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG4092 1286640016580 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1286640016581 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 1286640016582 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1286640016583 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1286640016584 trimer interface [polypeptide binding]; other site 1286640016585 active site 1286640016586 substrate binding site [chemical binding]; other site 1286640016587 CoA binding site [chemical binding]; other site 1286640016588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286640016589 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640016590 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640016591 HTH-like domain; Region: HTH_21; pfam13276 1286640016592 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1286640016593 Integrase core domain; Region: rve; pfam00665 1286640016594 Integrase core domain; Region: rve_2; pfam13333 1286640016595 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1286640016596 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1286640016597 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1286640016598 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1286640016599 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1286640016600 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1286640016601 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1286640016602 putative active site [active] 1286640016603 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1286640016604 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 1286640016605 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1286640016606 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1286640016607 Walker A/P-loop; other site 1286640016608 ATP binding site [chemical binding]; other site 1286640016609 Q-loop/lid; other site 1286640016610 ABC transporter signature motif; other site 1286640016611 Walker B; other site 1286640016612 D-loop; other site 1286640016613 H-loop/switch region; other site 1286640016614 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1286640016615 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1286640016616 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1286640016617 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 1286640016618 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1286640016619 active site 1286640016620 NTP binding site [chemical binding]; other site 1286640016621 metal binding triad [ion binding]; metal-binding site 1286640016622 antibiotic binding site [chemical binding]; other site 1286640016623 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748 1286640016624 Uncharacterized conserved protein [Function unknown]; Region: COG3347 1286640016625 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1286640016626 Uncharacterized conserved protein [Function unknown]; Region: COG5556 1286640016627 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 1286640016628 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1286640016629 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1286640016630 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1286640016631 dimer interface [polypeptide binding]; other site 1286640016632 substrate binding site [chemical binding]; other site 1286640016633 metal binding site [ion binding]; metal-binding site 1286640016634 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 1286640016635 Uncharacterized conserved protein [Function unknown]; Region: COG3347 1286640016636 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1286640016637 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1286640016638 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1286640016639 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640016640 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640016641 TM-ABC transporter signature motif; other site 1286640016642 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640016643 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640016644 TM-ABC transporter signature motif; other site 1286640016645 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1286640016646 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640016647 Walker A/P-loop; other site 1286640016648 ATP binding site [chemical binding]; other site 1286640016649 Q-loop/lid; other site 1286640016650 ABC transporter signature motif; other site 1286640016651 Walker B; other site 1286640016652 D-loop; other site 1286640016653 H-loop/switch region; other site 1286640016654 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640016655 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286640016656 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1286640016657 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286640016658 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1286640016659 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1286640016660 putative N- and C-terminal domain interface [polypeptide binding]; other site 1286640016661 putative active site [active] 1286640016662 putative MgATP binding site [chemical binding]; other site 1286640016663 catalytic site [active] 1286640016664 metal binding site [ion binding]; metal-binding site 1286640016665 putative carbohydrate binding site [chemical binding]; other site 1286640016666 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286640016667 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1286640016668 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1286640016669 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286640016670 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640016671 non-specific DNA binding site [nucleotide binding]; other site 1286640016672 salt bridge; other site 1286640016673 sequence-specific DNA binding site [nucleotide binding]; other site 1286640016674 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640016675 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1286640016676 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640016677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640016678 dimer interface [polypeptide binding]; other site 1286640016679 conserved gate region; other site 1286640016680 putative PBP binding loops; other site 1286640016681 ABC-ATPase subunit interface; other site 1286640016682 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286640016683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640016684 dimer interface [polypeptide binding]; other site 1286640016685 conserved gate region; other site 1286640016686 putative PBP binding loops; other site 1286640016687 ABC-ATPase subunit interface; other site 1286640016688 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1286640016689 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640016690 Walker A/P-loop; other site 1286640016691 ATP binding site [chemical binding]; other site 1286640016692 Q-loop/lid; other site 1286640016693 ABC transporter signature motif; other site 1286640016694 Walker B; other site 1286640016695 D-loop; other site 1286640016696 H-loop/switch region; other site 1286640016697 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640016698 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640016699 Walker A/P-loop; other site 1286640016700 ATP binding site [chemical binding]; other site 1286640016701 Q-loop/lid; other site 1286640016702 ABC transporter signature motif; other site 1286640016703 Walker B; other site 1286640016704 D-loop; other site 1286640016705 H-loop/switch region; other site 1286640016706 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1286640016707 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1286640016708 putative active site [active] 1286640016709 putative metal binding site [ion binding]; other site 1286640016710 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1286640016711 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1286640016712 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1286640016713 metal binding site [ion binding]; metal-binding site 1286640016714 dimer interface [polypeptide binding]; other site 1286640016715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1286640016716 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1286640016717 active site 1286640016718 DNA binding site [nucleotide binding] 1286640016719 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 1286640016720 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1286640016721 DNA binding site [nucleotide binding] 1286640016722 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1286640016723 nucleotide binding site [chemical binding]; other site 1286640016724 Staphylococcal nuclease homologues; Region: SNc; smart00318 1286640016725 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1286640016726 Catalytic site; other site 1286640016727 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1286640016728 GXWXG protein; Region: GXWXG; pfam14231 1286640016729 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1286640016730 Winged helix-turn helix; Region: HTH_29; pfam13551 1286640016731 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640016732 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286640016733 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286640016734 putative active site [active] 1286640016735 putative NTP binding site [chemical binding]; other site 1286640016736 putative nucleic acid binding site [nucleotide binding]; other site 1286640016737 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1286640016738 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1286640016739 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1286640016740 acyl carrier protein; Provisional; Region: acpP; PRK00982 1286640016741 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640016742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1286640016743 active site 1286640016744 phosphorylation site [posttranslational modification] 1286640016745 intermolecular recognition site; other site 1286640016746 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640016747 DNA binding residues [nucleotide binding] 1286640016748 dimerization interface [polypeptide binding]; other site 1286640016749 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1286640016750 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1286640016751 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1286640016752 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1286640016753 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1286640016754 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1286640016755 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640016756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640016757 NAD(P) binding site [chemical binding]; other site 1286640016758 active site 1286640016759 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640016760 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1286640016761 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286640016762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640016763 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1286640016764 Family description; Region: VCBS; pfam13517 1286640016765 Family description; Region: VCBS; pfam13517 1286640016766 Family description; Region: VCBS; pfam13517 1286640016767 Family description; Region: VCBS; pfam13517 1286640016768 Family description; Region: VCBS; pfam13517 1286640016769 Family description; Region: VCBS; pfam13517 1286640016770 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1286640016771 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1286640016772 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1286640016773 substrate binding site; other site 1286640016774 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1286640016775 extended (e) SDRs; Region: SDR_e; cd08946 1286640016776 NAD(P) binding site [chemical binding]; other site 1286640016777 active site 1286640016778 substrate binding site [chemical binding]; other site 1286640016779 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1286640016780 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286640016781 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1286640016782 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1286640016783 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286640016784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640016785 S-adenosylmethionine binding site [chemical binding]; other site 1286640016786 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1286640016787 Protein of unknown function (DUF707); Region: DUF707; pfam05212 1286640016788 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1286640016789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286640016790 active site 1286640016791 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286640016792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640016793 S-adenosylmethionine binding site [chemical binding]; other site 1286640016794 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1286640016795 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 1286640016796 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286640016797 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 1286640016798 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1286640016799 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1286640016800 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1286640016801 AAA domain; Region: AAA_31; pfam13614 1286640016802 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1286640016803 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1286640016804 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1286640016805 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1286640016806 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286640016807 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1286640016808 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640016809 putative ADP-binding pocket [chemical binding]; other site 1286640016810 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1286640016811 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640016812 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640016813 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1286640016814 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286640016815 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286640016816 ligand binding site [chemical binding]; other site 1286640016817 flexible hinge region; other site 1286640016818 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1286640016819 putative switch regulator; other site 1286640016820 non-specific DNA interactions [nucleotide binding]; other site 1286640016821 DNA binding site [nucleotide binding] 1286640016822 sequence specific DNA binding site [nucleotide binding]; other site 1286640016823 putative cAMP binding site [chemical binding]; other site 1286640016824 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640016825 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640016826 DNA binding residues [nucleotide binding] 1286640016827 dimerization interface [polypeptide binding]; other site 1286640016828 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1286640016829 active site 1286640016830 substrate binding site [chemical binding]; other site 1286640016831 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1286640016832 metal binding site [ion binding]; metal-binding site 1286640016833 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1286640016834 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1286640016835 Substrate binding site; other site 1286640016836 Cupin domain; Region: Cupin_2; cl17218 1286640016837 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1286640016838 dimerization interface [polypeptide binding]; other site 1286640016839 putative active cleft [active] 1286640016840 Transposase; Region: HTH_Tnp_1; pfam01527 1286640016841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286640016842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1286640016843 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1286640016844 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1286640016845 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1286640016846 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1286640016847 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1286640016848 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1286640016849 cyclase homology domain; Region: CHD; cd07302 1286640016850 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640016851 metal binding site [ion binding]; metal-binding site 1286640016852 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 1286640016853 MobA/MobL family; Region: MobA_MobL; pfam03389 1286640016854 AAA domain; Region: AAA_30; pfam13604 1286640016855 Family description; Region: UvrD_C_2; pfam13538 1286640016856 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1286640016857 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1286640016858 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640016859 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1286640016860 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 1286640016861 active site 1286640016862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640016863 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286640016864 Coenzyme A binding pocket [chemical binding]; other site 1286640016865 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286640016866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640016867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640016868 dimerization interface [polypeptide binding]; other site 1286640016869 argininosuccinate lyase; Provisional; Region: PRK00855 1286640016870 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1286640016871 active sites [active] 1286640016872 tetramer interface [polypeptide binding]; other site 1286640016873 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286640016874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640016875 dimer interface [polypeptide binding]; other site 1286640016876 conserved gate region; other site 1286640016877 putative PBP binding loops; other site 1286640016878 ABC-ATPase subunit interface; other site 1286640016879 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286640016880 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286640016881 Walker A/P-loop; other site 1286640016882 ATP binding site [chemical binding]; other site 1286640016883 Q-loop/lid; other site 1286640016884 ABC transporter signature motif; other site 1286640016885 Walker B; other site 1286640016886 D-loop; other site 1286640016887 H-loop/switch region; other site 1286640016888 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286640016889 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640016890 substrate binding pocket [chemical binding]; other site 1286640016891 membrane-bound complex binding site; other site 1286640016892 hinge residues; other site 1286640016893 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1286640016894 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1286640016895 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1286640016896 active site 1286640016897 catalytic site [active] 1286640016898 Zn binding site [ion binding]; other site 1286640016899 tetramer interface [polypeptide binding]; other site 1286640016900 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1286640016901 Amidohydrolase; Region: Amidohydro_2; pfam04909 1286640016902 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286640016903 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640016904 putative DNA binding site [nucleotide binding]; other site 1286640016905 putative Zn2+ binding site [ion binding]; other site 1286640016906 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286640016907 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640016908 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640016909 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640016910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640016911 dimer interface [polypeptide binding]; other site 1286640016912 conserved gate region; other site 1286640016913 putative PBP binding loops; other site 1286640016914 ABC-ATPase subunit interface; other site 1286640016915 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640016916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640016917 dimer interface [polypeptide binding]; other site 1286640016918 conserved gate region; other site 1286640016919 putative PBP binding loops; other site 1286640016920 ABC-ATPase subunit interface; other site 1286640016921 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640016922 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640016923 Walker A/P-loop; other site 1286640016924 ATP binding site [chemical binding]; other site 1286640016925 Q-loop/lid; other site 1286640016926 ABC transporter signature motif; other site 1286640016927 Walker B; other site 1286640016928 D-loop; other site 1286640016929 H-loop/switch region; other site 1286640016930 TOBE domain; Region: TOBE_2; pfam08402 1286640016931 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1286640016932 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1286640016933 active site pocket [active] 1286640016934 Uncharacterized conserved protein [Function unknown]; Region: COG3254 1286640016935 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640016936 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640016937 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1286640016938 active site 2 [active] 1286640016939 active site 1 [active] 1286640016940 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640016941 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1286640016942 NAD binding site [chemical binding]; other site 1286640016943 homotetramer interface [polypeptide binding]; other site 1286640016944 homodimer interface [polypeptide binding]; other site 1286640016945 active site 1286640016946 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1286640016947 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1286640016948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1286640016949 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 1286640016950 putative active site pocket [active] 1286640016951 metal binding site [ion binding]; metal-binding site 1286640016952 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1286640016953 NMT1-like family; Region: NMT1_2; pfam13379 1286640016954 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1286640016955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640016956 active site 1286640016957 phosphorylation site [posttranslational modification] 1286640016958 intermolecular recognition site; other site 1286640016959 ANTAR domain; Region: ANTAR; pfam03861 1286640016960 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1286640016961 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286640016962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640016963 non-specific DNA binding site [nucleotide binding]; other site 1286640016964 salt bridge; other site 1286640016965 sequence-specific DNA binding site [nucleotide binding]; other site 1286640016966 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1286640016967 Shikimate kinase; Region: SKI; pfam01202 1286640016968 isovaleryl-CoA dehydrogenase; Region: PLN02519 1286640016969 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1286640016970 substrate binding site [chemical binding]; other site 1286640016971 FAD binding site [chemical binding]; other site 1286640016972 catalytic base [active] 1286640016973 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1286640016974 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286640016975 homotrimer interaction site [polypeptide binding]; other site 1286640016976 putative active site [active] 1286640016977 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1286640016978 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286640016979 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1286640016980 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1286640016981 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1286640016982 carboxyltransferase (CT) interaction site; other site 1286640016983 biotinylation site [posttranslational modification]; other site 1286640016984 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1286640016985 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1286640016986 active site 1286640016987 catalytic residues [active] 1286640016988 metal binding site [ion binding]; metal-binding site 1286640016989 enoyl-CoA hydratase; Provisional; Region: PRK07468 1286640016990 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286640016991 substrate binding site [chemical binding]; other site 1286640016992 oxyanion hole (OAH) forming residues; other site 1286640016993 trimer interface [polypeptide binding]; other site 1286640016994 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1286640016995 Uncharacterized conserved protein [Function unknown]; Region: COG5654 1286640016996 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286640016997 FAD binding domain; Region: FAD_binding_4; pfam01565 1286640016998 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1286640016999 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1286640017000 Walker A/P-loop; other site 1286640017001 ATP binding site [chemical binding]; other site 1286640017002 Q-loop/lid; other site 1286640017003 ABC transporter signature motif; other site 1286640017004 Walker B; other site 1286640017005 D-loop; other site 1286640017006 H-loop/switch region; other site 1286640017007 TOBE-like domain; Region: TOBE_3; pfam12857 1286640017008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017009 dimer interface [polypeptide binding]; other site 1286640017010 conserved gate region; other site 1286640017011 putative PBP binding loops; other site 1286640017012 ABC-ATPase subunit interface; other site 1286640017013 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1286640017014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017015 dimer interface [polypeptide binding]; other site 1286640017016 conserved gate region; other site 1286640017017 putative PBP binding loops; other site 1286640017018 ABC-ATPase subunit interface; other site 1286640017019 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1286640017020 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1286640017021 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1286640017022 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 1286640017023 dimer interface [polypeptide binding]; other site 1286640017024 active site 1286640017025 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286640017026 substrate binding site [chemical binding]; other site 1286640017027 catalytic residue [active] 1286640017028 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286640017029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640017030 substrate binding pocket [chemical binding]; other site 1286640017031 membrane-bound complex binding site; other site 1286640017032 hinge residues; other site 1286640017033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017034 dimer interface [polypeptide binding]; other site 1286640017035 conserved gate region; other site 1286640017036 putative PBP binding loops; other site 1286640017037 ABC-ATPase subunit interface; other site 1286640017038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017039 dimer interface [polypeptide binding]; other site 1286640017040 conserved gate region; other site 1286640017041 putative PBP binding loops; other site 1286640017042 ABC-ATPase subunit interface; other site 1286640017043 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286640017044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640017045 Walker A/P-loop; other site 1286640017046 ATP binding site [chemical binding]; other site 1286640017047 Q-loop/lid; other site 1286640017048 ABC transporter signature motif; other site 1286640017049 Walker B; other site 1286640017050 D-loop; other site 1286640017051 H-loop/switch region; other site 1286640017052 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286640017053 homotrimer interaction site [polypeptide binding]; other site 1286640017054 putative active site [active] 1286640017055 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286640017056 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1286640017057 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286640017058 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640017059 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640017060 Walker A/P-loop; other site 1286640017061 ATP binding site [chemical binding]; other site 1286640017062 Q-loop/lid; other site 1286640017063 ABC transporter signature motif; other site 1286640017064 Walker B; other site 1286640017065 D-loop; other site 1286640017066 H-loop/switch region; other site 1286640017067 TOBE domain; Region: TOBE_2; pfam08402 1286640017068 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286640017069 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1286640017070 substrate binding site [chemical binding]; other site 1286640017071 ATP binding site [chemical binding]; other site 1286640017072 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1286640017073 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1286640017074 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1286640017075 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640017076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017077 dimer interface [polypeptide binding]; other site 1286640017078 conserved gate region; other site 1286640017079 putative PBP binding loops; other site 1286640017080 ABC-ATPase subunit interface; other site 1286640017081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017082 dimer interface [polypeptide binding]; other site 1286640017083 conserved gate region; other site 1286640017084 putative PBP binding loops; other site 1286640017085 ABC-ATPase subunit interface; other site 1286640017086 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640017087 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640017088 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1286640017089 non-specific DNA interactions [nucleotide binding]; other site 1286640017090 DNA binding site [nucleotide binding] 1286640017091 sequence specific DNA binding site [nucleotide binding]; other site 1286640017092 putative cAMP binding site [chemical binding]; other site 1286640017093 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286640017094 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286640017095 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1286640017096 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1286640017097 Active Sites [active] 1286640017098 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1286640017099 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1286640017100 CysD dimerization site [polypeptide binding]; other site 1286640017101 G1 box; other site 1286640017102 putative GEF interaction site [polypeptide binding]; other site 1286640017103 GTP/Mg2+ binding site [chemical binding]; other site 1286640017104 Switch I region; other site 1286640017105 G2 box; other site 1286640017106 G3 box; other site 1286640017107 Switch II region; other site 1286640017108 G4 box; other site 1286640017109 G5 box; other site 1286640017110 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1286640017111 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1286640017112 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1286640017113 ligand-binding site [chemical binding]; other site 1286640017114 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1286640017115 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1286640017116 active site 1286640017117 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 1286640017118 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1286640017119 active site 1286640017120 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1286640017121 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1286640017122 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640017123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640017124 NAD(P) binding site [chemical binding]; other site 1286640017125 active site 1286640017126 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1286640017127 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1286640017128 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1286640017129 putative ADP-binding pocket [chemical binding]; other site 1286640017130 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1286640017131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640017132 putative ADP-binding pocket [chemical binding]; other site 1286640017133 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1286640017134 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1286640017135 NAD(P) binding site [chemical binding]; other site 1286640017136 homodimer interface [polypeptide binding]; other site 1286640017137 substrate binding site [chemical binding]; other site 1286640017138 active site 1286640017139 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 1286640017140 HTH-like domain; Region: HTH_21; pfam13276 1286640017141 Integrase core domain; Region: rve; pfam00665 1286640017142 Integrase core domain; Region: rve_3; pfam13683 1286640017143 Transposase; Region: HTH_Tnp_1; cl17663 1286640017144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286640017145 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 1286640017146 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651 1286640017147 putative active site [active] 1286640017148 putative substrate binding site [chemical binding]; other site 1286640017149 putative cosubstrate binding site; other site 1286640017150 catalytic site [active] 1286640017151 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1286640017152 active site 1286640017153 hexamer interface [polypeptide binding]; other site 1286640017154 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1286640017155 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1286640017156 Chain length determinant protein; Region: Wzz; pfam02706 1286640017157 Chain length determinant protein; Region: Wzz; cl15801 1286640017158 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1286640017159 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1286640017160 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1286640017161 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1286640017162 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1286640017163 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1286640017164 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1286640017165 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1286640017166 SLBB domain; Region: SLBB; pfam10531 1286640017167 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1286640017168 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1286640017169 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1286640017170 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1286640017171 inhibitor-cofactor binding pocket; inhibition site 1286640017172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640017173 catalytic residue [active] 1286640017174 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1286640017175 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640017176 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1286640017177 putative ADP-binding pocket [chemical binding]; other site 1286640017178 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1286640017179 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286640017180 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640017181 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1286640017182 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 1286640017183 NodB motif; other site 1286640017184 putative active site [active] 1286640017185 putative catalytic site [active] 1286640017186 putative Zn binding site [ion binding]; other site 1286640017187 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1286640017188 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 1286640017189 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1286640017190 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1286640017191 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1286640017192 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1286640017193 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640017194 cyclase homology domain; Region: CHD; cd07302 1286640017195 nucleotidyl binding site; other site 1286640017196 metal binding site [ion binding]; metal-binding site 1286640017197 dimer interface [polypeptide binding]; other site 1286640017198 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1286640017199 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1286640017200 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640017201 Walker A/P-loop; other site 1286640017202 ATP binding site [chemical binding]; other site 1286640017203 Q-loop/lid; other site 1286640017204 ABC transporter signature motif; other site 1286640017205 Walker B; other site 1286640017206 D-loop; other site 1286640017207 H-loop/switch region; other site 1286640017208 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640017209 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640017210 Walker A/P-loop; other site 1286640017211 ATP binding site [chemical binding]; other site 1286640017212 Q-loop/lid; other site 1286640017213 ABC transporter signature motif; other site 1286640017214 Walker B; other site 1286640017215 D-loop; other site 1286640017216 H-loop/switch region; other site 1286640017217 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640017218 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1286640017219 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1286640017220 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640017221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017222 dimer interface [polypeptide binding]; other site 1286640017223 conserved gate region; other site 1286640017224 putative PBP binding loops; other site 1286640017225 ABC-ATPase subunit interface; other site 1286640017226 microcin C ABC transporter permease; Provisional; Region: PRK15021 1286640017227 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1286640017228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017229 dimer interface [polypeptide binding]; other site 1286640017230 conserved gate region; other site 1286640017231 putative PBP binding loops; other site 1286640017232 ABC-ATPase subunit interface; other site 1286640017233 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1286640017234 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1286640017235 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1286640017236 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640017237 putative ADP-binding pocket [chemical binding]; other site 1286640017238 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1286640017239 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1286640017240 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640017241 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286640017242 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1286640017243 Walker A/P-loop; other site 1286640017244 ATP binding site [chemical binding]; other site 1286640017245 Q-loop/lid; other site 1286640017246 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286640017247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640017248 ABC transporter signature motif; other site 1286640017249 Walker B; other site 1286640017250 D-loop; other site 1286640017251 H-loop/switch region; other site 1286640017252 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286640017253 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286640017254 ligand binding site [chemical binding]; other site 1286640017255 flexible hinge region; other site 1286640017256 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1286640017257 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640017258 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640017259 DNA binding site [nucleotide binding] 1286640017260 domain linker motif; other site 1286640017261 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1286640017262 dimerization interface [polypeptide binding]; other site 1286640017263 ligand binding site [chemical binding]; other site 1286640017264 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1286640017265 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286640017266 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286640017267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017268 dimer interface [polypeptide binding]; other site 1286640017269 conserved gate region; other site 1286640017270 putative PBP binding loops; other site 1286640017271 ABC-ATPase subunit interface; other site 1286640017272 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640017273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017274 dimer interface [polypeptide binding]; other site 1286640017275 conserved gate region; other site 1286640017276 putative PBP binding loops; other site 1286640017277 ABC-ATPase subunit interface; other site 1286640017278 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640017279 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1286640017280 Walker A/P-loop; other site 1286640017281 ATP binding site [chemical binding]; other site 1286640017282 Q-loop/lid; other site 1286640017283 ABC transporter signature motif; other site 1286640017284 Walker B; other site 1286640017285 D-loop; other site 1286640017286 H-loop/switch region; other site 1286640017287 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1286640017288 active site 1286640017289 tetramer interface [polypeptide binding]; other site 1286640017290 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1286640017291 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286640017292 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1286640017293 active site 1286640017294 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1286640017295 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1286640017296 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1286640017297 metal binding site [ion binding]; metal-binding site 1286640017298 putative dimer interface [polypeptide binding]; other site 1286640017299 phosphoribosyltransferase; Provisional; Region: PRK06031 1286640017300 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1286640017301 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1286640017302 Allantoicase [Nucleotide transport and metabolism]; Region: Alc; COG4266 1286640017303 Allantoicase repeat; Region: Allantoicase; pfam03561 1286640017304 Allantoicase repeat; Region: Allantoicase; pfam03561 1286640017305 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1286640017306 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1286640017307 active site 1286640017308 catalytic site [active] 1286640017309 tetramer interface [polypeptide binding]; other site 1286640017310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1286640017311 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1286640017312 active site 1286640017313 homotetramer interface [polypeptide binding]; other site 1286640017314 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 1286640017315 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640017316 catalytic loop [active] 1286640017317 iron binding site [ion binding]; other site 1286640017318 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1286640017319 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1286640017320 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 1286640017321 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1286640017322 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640017323 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1286640017324 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1286640017325 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1286640017326 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286640017327 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286640017328 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286640017329 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286640017330 NAD(P) binding site [chemical binding]; other site 1286640017331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640017332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640017333 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640017334 putative effector binding pocket; other site 1286640017335 dimerization interface [polypeptide binding]; other site 1286640017336 Predicted membrane protein [Function unknown]; Region: COG3748 1286640017337 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1286640017338 Cytochrome c; Region: Cytochrom_C; pfam00034 1286640017339 guanine deaminase; Provisional; Region: PRK09228 1286640017340 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1286640017341 active site 1286640017342 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1286640017343 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1286640017344 putative dimer interface [polypeptide binding]; other site 1286640017345 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1286640017346 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1286640017347 putative dimer interface [polypeptide binding]; other site 1286640017348 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1286640017349 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 1286640017350 Transglycosylase; Region: Transgly; pfam00912 1286640017351 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1286640017352 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1286640017353 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 1286640017354 putative binding site; other site 1286640017355 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1286640017356 MG2 domain; Region: A2M_N; pfam01835 1286640017357 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1286640017358 surface patch; other site 1286640017359 thioester region; other site 1286640017360 specificity defining residues; other site 1286640017361 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1286640017362 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1286640017363 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286640017364 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1286640017365 intersubunit interface [polypeptide binding]; other site 1286640017366 active site 1286640017367 catalytic residue [active] 1286640017368 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1286640017369 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286640017370 NAD(P) binding site [chemical binding]; other site 1286640017371 catalytic residues [active] 1286640017372 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1286640017373 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1286640017374 NAD(P) binding site [chemical binding]; other site 1286640017375 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 1286640017376 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1286640017377 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1286640017378 Amidinotransferase; Region: Amidinotransf; cl12043 1286640017379 mercuric reductase; Validated; Region: PRK06370 1286640017380 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1286640017381 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640017382 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286640017383 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1286640017384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017385 dimer interface [polypeptide binding]; other site 1286640017386 conserved gate region; other site 1286640017387 ABC-ATPase subunit interface; other site 1286640017388 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1286640017389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640017390 Walker A/P-loop; other site 1286640017391 ATP binding site [chemical binding]; other site 1286640017392 Q-loop/lid; other site 1286640017393 ABC transporter signature motif; other site 1286640017394 Walker B; other site 1286640017395 D-loop; other site 1286640017396 H-loop/switch region; other site 1286640017397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017398 dimer interface [polypeptide binding]; other site 1286640017399 conserved gate region; other site 1286640017400 putative PBP binding loops; other site 1286640017401 ABC-ATPase subunit interface; other site 1286640017402 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640017403 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640017404 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640017405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017406 dimer interface [polypeptide binding]; other site 1286640017407 conserved gate region; other site 1286640017408 putative PBP binding loops; other site 1286640017409 ABC-ATPase subunit interface; other site 1286640017410 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640017411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017412 dimer interface [polypeptide binding]; other site 1286640017413 conserved gate region; other site 1286640017414 putative PBP binding loops; other site 1286640017415 ABC-ATPase subunit interface; other site 1286640017416 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640017417 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286640017418 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640017419 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640017420 Walker A/P-loop; other site 1286640017421 ATP binding site [chemical binding]; other site 1286640017422 Q-loop/lid; other site 1286640017423 ABC transporter signature motif; other site 1286640017424 Walker B; other site 1286640017425 D-loop; other site 1286640017426 H-loop/switch region; other site 1286640017427 TOBE domain; Region: TOBE_2; pfam08402 1286640017428 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1286640017429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286640017430 Coenzyme A binding pocket [chemical binding]; other site 1286640017431 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1286640017432 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640017433 active site 1286640017434 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1286640017435 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1286640017436 MlrC C-terminus; Region: MlrC_C; pfam07171 1286640017437 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286640017438 homotrimer interaction site [polypeptide binding]; other site 1286640017439 putative active site [active] 1286640017440 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286640017441 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286640017442 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286640017443 putative active site [active] 1286640017444 short chain dehydrogenase; Provisional; Region: PRK07074 1286640017445 classical (c) SDRs; Region: SDR_c; cd05233 1286640017446 NAD(P) binding site [chemical binding]; other site 1286640017447 active site 1286640017448 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1286640017449 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1286640017450 active site 1286640017451 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1286640017452 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1286640017453 MlrC C-terminus; Region: MlrC_C; pfam07171 1286640017454 sugar efflux transporter; Region: 2A0120; TIGR00899 1286640017455 urocanate hydratase; Provisional; Region: PRK05414 1286640017456 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1286640017457 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1286640017458 active sites [active] 1286640017459 tetramer interface [polypeptide binding]; other site 1286640017460 imidazolonepropionase; Validated; Region: PRK09356 1286640017461 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1286640017462 active site 1286640017463 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1286640017464 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286640017465 putative active site [active] 1286640017466 putative NTP binding site [chemical binding]; other site 1286640017467 putative nucleic acid binding site [nucleotide binding]; other site 1286640017468 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1286640017469 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286640017470 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640017471 putative DNA binding site [nucleotide binding]; other site 1286640017472 putative Zn2+ binding site [ion binding]; other site 1286640017473 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 1286640017474 active site 1286640017475 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 1286640017476 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286640017477 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1286640017478 active site 1286640017479 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 1286640017480 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1286640017481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017482 dimer interface [polypeptide binding]; other site 1286640017483 conserved gate region; other site 1286640017484 ABC-ATPase subunit interface; other site 1286640017485 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1286640017486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017487 dimer interface [polypeptide binding]; other site 1286640017488 conserved gate region; other site 1286640017489 ABC-ATPase subunit interface; other site 1286640017490 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1286640017491 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1286640017492 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1286640017493 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1286640017494 Walker A/P-loop; other site 1286640017495 ATP binding site [chemical binding]; other site 1286640017496 Q-loop/lid; other site 1286640017497 ABC transporter signature motif; other site 1286640017498 Walker B; other site 1286640017499 D-loop; other site 1286640017500 H-loop/switch region; other site 1286640017501 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 1286640017502 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640017503 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1286640017504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640017505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640017506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286640017507 dimerization interface [polypeptide binding]; other site 1286640017508 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1286640017509 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286640017510 FAD binding site [chemical binding]; other site 1286640017511 substrate binding pocket [chemical binding]; other site 1286640017512 catalytic base [active] 1286640017513 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1286640017514 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1286640017515 heat shock protein 90; Provisional; Region: PRK05218 1286640017516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640017517 ATP binding site [chemical binding]; other site 1286640017518 Mg2+ binding site [ion binding]; other site 1286640017519 G-X-G motif; other site 1286640017520 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 1286640017521 propionate/acetate kinase; Provisional; Region: PRK12379 1286640017522 succinic semialdehyde dehydrogenase; Region: PLN02278 1286640017523 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1286640017524 tetramerization interface [polypeptide binding]; other site 1286640017525 NAD(P) binding site [chemical binding]; other site 1286640017526 catalytic residues [active] 1286640017527 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 1286640017528 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640017529 inhibitor-cofactor binding pocket; inhibition site 1286640017530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640017531 catalytic residue [active] 1286640017532 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1286640017533 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286640017534 DNA binding residues [nucleotide binding] 1286640017535 dimer interface [polypeptide binding]; other site 1286640017536 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1286640017537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640017538 non-specific DNA binding site [nucleotide binding]; other site 1286640017539 salt bridge; other site 1286640017540 sequence-specific DNA binding site [nucleotide binding]; other site 1286640017541 Cupin domain; Region: Cupin_2; pfam07883 1286640017542 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1286640017543 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1286640017544 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286640017545 active site 1286640017546 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1286640017547 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1286640017548 active site 1286640017549 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640017550 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1286640017551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640017552 Walker A/P-loop; other site 1286640017553 ATP binding site [chemical binding]; other site 1286640017554 Q-loop/lid; other site 1286640017555 ABC transporter signature motif; other site 1286640017556 Walker B; other site 1286640017557 D-loop; other site 1286640017558 H-loop/switch region; other site 1286640017559 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1286640017560 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1286640017561 intersubunit interface [polypeptide binding]; other site 1286640017562 active site 1286640017563 zinc binding site [ion binding]; other site 1286640017564 Na+ binding site [ion binding]; other site 1286640017565 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286640017566 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286640017567 peptide binding site [polypeptide binding]; other site 1286640017568 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1286640017569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017570 dimer interface [polypeptide binding]; other site 1286640017571 conserved gate region; other site 1286640017572 putative PBP binding loops; other site 1286640017573 ABC-ATPase subunit interface; other site 1286640017574 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1286640017575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017576 dimer interface [polypeptide binding]; other site 1286640017577 conserved gate region; other site 1286640017578 ABC-ATPase subunit interface; other site 1286640017579 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1286640017580 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640017581 Walker A/P-loop; other site 1286640017582 ATP binding site [chemical binding]; other site 1286640017583 Q-loop/lid; other site 1286640017584 ABC transporter signature motif; other site 1286640017585 Walker B; other site 1286640017586 D-loop; other site 1286640017587 H-loop/switch region; other site 1286640017588 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1286640017589 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640017590 Walker A/P-loop; other site 1286640017591 ATP binding site [chemical binding]; other site 1286640017592 Q-loop/lid; other site 1286640017593 ABC transporter signature motif; other site 1286640017594 Walker B; other site 1286640017595 D-loop; other site 1286640017596 H-loop/switch region; other site 1286640017597 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640017598 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1286640017599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640017600 active site 1286640017601 phosphorylation site [posttranslational modification] 1286640017602 intermolecular recognition site; other site 1286640017603 dimerization interface [polypeptide binding]; other site 1286640017604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640017605 Walker A motif; other site 1286640017606 ATP binding site [chemical binding]; other site 1286640017607 Walker B motif; other site 1286640017608 arginine finger; other site 1286640017609 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286640017610 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1286640017611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640017612 dimer interface [polypeptide binding]; other site 1286640017613 phosphorylation site [posttranslational modification] 1286640017614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640017615 ATP binding site [chemical binding]; other site 1286640017616 Mg2+ binding site [ion binding]; other site 1286640017617 G-X-G motif; other site 1286640017618 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1286640017619 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286640017620 Zn binding site [ion binding]; other site 1286640017621 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1286640017622 Zn binding site [ion binding]; other site 1286640017623 Predicted esterase [General function prediction only]; Region: COG0400 1286640017624 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1286640017625 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1286640017626 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1286640017627 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1286640017628 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1286640017629 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286640017630 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286640017631 Walker A/P-loop; other site 1286640017632 ATP binding site [chemical binding]; other site 1286640017633 Q-loop/lid; other site 1286640017634 ABC transporter signature motif; other site 1286640017635 Walker B; other site 1286640017636 D-loop; other site 1286640017637 H-loop/switch region; other site 1286640017638 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1286640017639 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286640017640 Walker A/P-loop; other site 1286640017641 ATP binding site [chemical binding]; other site 1286640017642 Q-loop/lid; other site 1286640017643 ABC transporter signature motif; other site 1286640017644 Walker B; other site 1286640017645 D-loop; other site 1286640017646 H-loop/switch region; other site 1286640017647 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1286640017648 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640017649 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640017650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640017651 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1286640017652 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640017653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640017654 dimer interface [polypeptide binding]; other site 1286640017655 phosphorylation site [posttranslational modification] 1286640017656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640017657 ATP binding site [chemical binding]; other site 1286640017658 Mg2+ binding site [ion binding]; other site 1286640017659 G-X-G motif; other site 1286640017660 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640017661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640017662 active site 1286640017663 phosphorylation site [posttranslational modification] 1286640017664 intermolecular recognition site; other site 1286640017665 dimerization interface [polypeptide binding]; other site 1286640017666 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640017667 DNA binding site [nucleotide binding] 1286640017668 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1286640017669 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1286640017670 Sulfatase; Region: Sulfatase; pfam00884 1286640017671 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1286640017672 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286640017673 active site 1286640017674 metal binding site [ion binding]; metal-binding site 1286640017675 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640017676 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1286640017677 motif I; other site 1286640017678 active site 1286640017679 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286640017680 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1286640017681 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640017682 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 1286640017683 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640017684 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 1286640017685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640017686 S-adenosylmethionine binding site [chemical binding]; other site 1286640017687 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1286640017688 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1286640017689 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286640017690 active site 1286640017691 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1286640017692 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1286640017693 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1286640017694 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1286640017695 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640017696 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1286640017697 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640017698 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1286640017699 Walker A/P-loop; other site 1286640017700 ATP binding site [chemical binding]; other site 1286640017701 Q-loop/lid; other site 1286640017702 ABC transporter signature motif; other site 1286640017703 Walker B; other site 1286640017704 D-loop; other site 1286640017705 H-loop/switch region; other site 1286640017706 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286640017707 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1286640017708 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640017709 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 1286640017710 putative ADP-binding pocket [chemical binding]; other site 1286640017711 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286640017712 active site 1286640017713 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640017714 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1286640017715 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1286640017716 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1286640017717 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1286640017718 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1286640017719 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1286640017720 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1286640017721 substrate binding site; other site 1286640017722 tetramer interface; other site 1286640017723 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1286640017724 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1286640017725 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1286640017726 NAD binding site [chemical binding]; other site 1286640017727 substrate binding site [chemical binding]; other site 1286640017728 homodimer interface [polypeptide binding]; other site 1286640017729 active site 1286640017730 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1286640017731 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1286640017732 NADP binding site [chemical binding]; other site 1286640017733 active site 1286640017734 putative substrate binding site [chemical binding]; other site 1286640017735 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 1286640017736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1286640017737 BON domain; Region: BON; cl02771 1286640017738 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1286640017739 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1286640017740 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1286640017741 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640017742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640017743 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1286640017744 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1286640017745 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1286640017746 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1286640017747 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1286640017748 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1286640017749 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640017750 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1286640017751 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1286640017752 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640017753 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640017754 TM-ABC transporter signature motif; other site 1286640017755 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640017756 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640017757 TM-ABC transporter signature motif; other site 1286640017758 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640017759 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640017760 Walker A/P-loop; other site 1286640017761 ATP binding site [chemical binding]; other site 1286640017762 Q-loop/lid; other site 1286640017763 ABC transporter signature motif; other site 1286640017764 Walker B; other site 1286640017765 D-loop; other site 1286640017766 H-loop/switch region; other site 1286640017767 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640017768 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640017769 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1286640017770 putative ligand binding site [chemical binding]; other site 1286640017771 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640017772 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640017773 DNA binding site [nucleotide binding] 1286640017774 domain linker motif; other site 1286640017775 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1286640017776 putative dimerization interface [polypeptide binding]; other site 1286640017777 putative ligand binding site [chemical binding]; other site 1286640017778 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1286640017779 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 1286640017780 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1286640017781 NADP binding site [chemical binding]; other site 1286640017782 homodimer interface [polypeptide binding]; other site 1286640017783 active site 1286640017784 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1286640017785 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640017786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640017787 DNA-binding site [nucleotide binding]; DNA binding site 1286640017788 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286640017789 DctM-like transporters; Region: DctM; pfam06808 1286640017790 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1286640017791 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1286640017792 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1286640017793 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1286640017794 glucuronate isomerase; Reviewed; Region: PRK02925 1286640017795 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1286640017796 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640017797 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640017798 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286640017799 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1286640017800 Predicted membrane protein [Function unknown]; Region: COG4244 1286640017801 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1286640017802 catalytic triad [active] 1286640017803 conserved cis-peptide bond; other site 1286640017804 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640017805 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640017806 Predicted membrane protein [Function unknown]; Region: COG2323 1286640017807 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1286640017808 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1286640017809 Predicted membrane protein [Function unknown]; Region: COG4244 1286640017810 Predicted membrane protein [Function unknown]; Region: COG3336 1286640017811 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286640017812 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1286640017813 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1286640017814 Cytochrome c; Region: Cytochrom_C; cl11414 1286640017815 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1286640017816 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1286640017817 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 1286640017818 Cytochrome c; Region: Cytochrom_C; pfam00034 1286640017819 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1286640017820 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1286640017821 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1286640017822 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1286640017823 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1286640017824 D-pathway; other site 1286640017825 Putative ubiquinol binding site [chemical binding]; other site 1286640017826 Low-spin heme (heme b) binding site [chemical binding]; other site 1286640017827 Putative water exit pathway; other site 1286640017828 Binuclear center (heme o3/CuB) [ion binding]; other site 1286640017829 K-pathway; other site 1286640017830 Putative proton exit pathway; other site 1286640017831 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640017832 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640017833 DNA binding site [nucleotide binding] 1286640017834 domain linker motif; other site 1286640017835 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1286640017836 dimerization interface [polypeptide binding]; other site 1286640017837 ligand binding site [chemical binding]; other site 1286640017838 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 1286640017839 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286640017840 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1286640017841 substrate binding site [chemical binding]; other site 1286640017842 ATP binding site [chemical binding]; other site 1286640017843 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640017844 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640017845 TM-ABC transporter signature motif; other site 1286640017846 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640017847 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640017848 Walker A/P-loop; other site 1286640017849 ATP binding site [chemical binding]; other site 1286640017850 Q-loop/lid; other site 1286640017851 ABC transporter signature motif; other site 1286640017852 Walker B; other site 1286640017853 D-loop; other site 1286640017854 H-loop/switch region; other site 1286640017855 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640017856 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 1286640017857 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640017858 putative ligand binding site [chemical binding]; other site 1286640017859 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1286640017860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1286640017861 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1286640017862 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 1286640017863 active site 1286640017864 short chain dehydrogenase; Provisional; Region: PRK12937 1286640017865 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1286640017866 NADP binding site [chemical binding]; other site 1286640017867 homodimer interface [polypeptide binding]; other site 1286640017868 active site 1286640017869 substrate binding site [chemical binding]; other site 1286640017870 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1286640017871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640017872 NAD(P) binding site [chemical binding]; other site 1286640017873 active site 1286640017874 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1286640017875 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640017876 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286640017877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640017878 DNA-binding site [nucleotide binding]; DNA binding site 1286640017879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286640017880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640017881 homodimer interface [polypeptide binding]; other site 1286640017882 catalytic residue [active] 1286640017883 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1286640017884 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640017885 substrate binding pocket [chemical binding]; other site 1286640017886 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1286640017887 membrane-bound complex binding site; other site 1286640017888 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 1286640017889 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286640017890 Walker A/P-loop; other site 1286640017891 ATP binding site [chemical binding]; other site 1286640017892 Q-loop/lid; other site 1286640017893 ABC transporter signature motif; other site 1286640017894 Walker B; other site 1286640017895 D-loop; other site 1286640017896 H-loop/switch region; other site 1286640017897 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286640017898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017899 dimer interface [polypeptide binding]; other site 1286640017900 conserved gate region; other site 1286640017901 putative PBP binding loops; other site 1286640017902 ABC-ATPase subunit interface; other site 1286640017903 SnoaL-like domain; Region: SnoaL_2; pfam12680 1286640017904 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286640017905 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640017906 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 1286640017907 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286640017908 PYR/PP interface [polypeptide binding]; other site 1286640017909 dimer interface [polypeptide binding]; other site 1286640017910 TPP binding site [chemical binding]; other site 1286640017911 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286640017912 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 1286640017913 TPP-binding site; other site 1286640017914 Predicted membrane protein [Function unknown]; Region: COG2855 1286640017915 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1286640017916 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1286640017917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640017918 DNA-binding site [nucleotide binding]; DNA binding site 1286640017919 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286640017920 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640017921 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286640017922 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1286640017923 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1286640017924 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1286640017925 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1286640017926 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1286640017927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640017928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286640017929 dimerization interface [polypeptide binding]; other site 1286640017930 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1286640017931 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1286640017932 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1286640017933 PhoU domain; Region: PhoU; pfam01895 1286640017934 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1286640017935 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286640017936 catalytic residue [active] 1286640017937 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1286640017938 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1286640017939 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 1286640017940 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 1286640017941 NAD(P) binding site [chemical binding]; other site 1286640017942 catalytic residues [active] 1286640017943 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1286640017944 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286640017945 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1286640017946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640017947 Walker A/P-loop; other site 1286640017948 ATP binding site [chemical binding]; other site 1286640017949 Q-loop/lid; other site 1286640017950 ABC transporter signature motif; other site 1286640017951 Walker B; other site 1286640017952 D-loop; other site 1286640017953 H-loop/switch region; other site 1286640017954 TOBE domain; Region: TOBE_2; pfam08402 1286640017955 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1286640017956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017957 dimer interface [polypeptide binding]; other site 1286640017958 conserved gate region; other site 1286640017959 putative PBP binding loops; other site 1286640017960 ABC-ATPase subunit interface; other site 1286640017961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640017962 dimer interface [polypeptide binding]; other site 1286640017963 conserved gate region; other site 1286640017964 putative PBP binding loops; other site 1286640017965 ABC-ATPase subunit interface; other site 1286640017966 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1286640017967 active site 1286640017968 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1286640017969 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1286640017970 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1286640017971 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1286640017972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640017973 active site 1286640017974 phosphorylation site [posttranslational modification] 1286640017975 intermolecular recognition site; other site 1286640017976 dimerization interface [polypeptide binding]; other site 1286640017977 LytTr DNA-binding domain; Region: LytTR; pfam04397 1286640017978 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1286640017979 Histidine kinase; Region: His_kinase; pfam06580 1286640017980 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1286640017981 ATP binding site [chemical binding]; other site 1286640017982 Mg2+ binding site [ion binding]; other site 1286640017983 G-X-G motif; other site 1286640017984 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1286640017985 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1286640017986 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1286640017987 active site residue [active] 1286640017988 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1286640017989 active site residue [active] 1286640017990 Sulphur transport; Region: Sulf_transp; pfam04143 1286640017991 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1286640017992 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1286640017993 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1286640017994 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1286640017995 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1286640017996 TrkA-N domain; Region: TrkA_N; pfam02254 1286640017997 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1286640017998 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1286640017999 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640018000 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1286640018001 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1286640018002 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1286640018003 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640018004 catalytic loop [active] 1286640018005 iron binding site [ion binding]; other site 1286640018006 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1286640018007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640018008 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640018009 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640018010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640018011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286640018012 dimerization interface [polypeptide binding]; other site 1286640018013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640018014 dimer interface [polypeptide binding]; other site 1286640018015 phosphorylation site [posttranslational modification] 1286640018016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640018017 ATP binding site [chemical binding]; other site 1286640018018 G-X-G motif; other site 1286640018019 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640018020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640018021 active site 1286640018022 phosphorylation site [posttranslational modification] 1286640018023 intermolecular recognition site; other site 1286640018024 dimerization interface [polypeptide binding]; other site 1286640018025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640018026 DNA binding site [nucleotide binding] 1286640018027 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1286640018028 dimer interface [polypeptide binding]; other site 1286640018029 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1286640018030 active site 1286640018031 catalytic site [active] 1286640018032 substrate binding site [chemical binding]; other site 1286640018033 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1286640018034 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1286640018035 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1286640018036 ring oligomerisation interface [polypeptide binding]; other site 1286640018037 ATP/Mg binding site [chemical binding]; other site 1286640018038 stacking interactions; other site 1286640018039 hinge regions; other site 1286640018040 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1286640018041 oligomerisation interface [polypeptide binding]; other site 1286640018042 mobile loop; other site 1286640018043 roof hairpin; other site 1286640018044 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 1286640018045 Cupin domain; Region: Cupin_2; cl17218 1286640018046 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1286640018047 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1286640018048 putative active site [active] 1286640018049 putative FMN binding site [chemical binding]; other site 1286640018050 putative substrate binding site [chemical binding]; other site 1286640018051 putative catalytic residue [active] 1286640018052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286640018053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286640018054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286640018055 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1286640018056 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1286640018057 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1286640018058 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640018059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1286640018060 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286640018061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640018062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640018063 ATP binding site [chemical binding]; other site 1286640018064 Mg2+ binding site [ion binding]; other site 1286640018065 G-X-G motif; other site 1286640018066 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286640018067 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640018068 dimerization interface [polypeptide binding]; other site 1286640018069 putative DNA binding site [nucleotide binding]; other site 1286640018070 putative Zn2+ binding site [ion binding]; other site 1286640018071 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286640018072 metal-binding site [ion binding] 1286640018073 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1286640018074 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286640018075 metal-binding site [ion binding] 1286640018076 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1286640018077 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286640018078 metal-binding site [ion binding] 1286640018079 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286640018080 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640018081 motif II; other site 1286640018082 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1286640018083 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1286640018084 DNA binding residues [nucleotide binding] 1286640018085 dimer interface [polypeptide binding]; other site 1286640018086 copper binding site [ion binding]; other site 1286640018087 Predicted membrane protein [Function unknown]; Region: COG1238 1286640018088 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1286640018089 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640018090 putative ADP-binding pocket [chemical binding]; other site 1286640018091 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 1286640018092 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 1286640018093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3930 1286640018094 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1286640018095 glutathione synthetase; Provisional; Region: PRK12458 1286640018096 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1286640018097 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640018098 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1286640018099 putative ligand binding site [chemical binding]; other site 1286640018100 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640018101 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640018102 Walker A/P-loop; other site 1286640018103 ATP binding site [chemical binding]; other site 1286640018104 Q-loop/lid; other site 1286640018105 ABC transporter signature motif; other site 1286640018106 Walker B; other site 1286640018107 D-loop; other site 1286640018108 H-loop/switch region; other site 1286640018109 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640018110 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640018111 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640018112 TM-ABC transporter signature motif; other site 1286640018113 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640018114 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640018115 TM-ABC transporter signature motif; other site 1286640018116 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640018117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640018118 DNA-binding site [nucleotide binding]; DNA binding site 1286640018119 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640018120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640018121 Walker A/P-loop; other site 1286640018122 ATP binding site [chemical binding]; other site 1286640018123 Q-loop/lid; other site 1286640018124 ABC transporter signature motif; other site 1286640018125 Walker B; other site 1286640018126 D-loop; other site 1286640018127 H-loop/switch region; other site 1286640018128 TOBE domain; Region: TOBE; cl01440 1286640018129 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640018130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640018131 dimer interface [polypeptide binding]; other site 1286640018132 conserved gate region; other site 1286640018133 ABC-ATPase subunit interface; other site 1286640018134 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640018135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640018136 dimer interface [polypeptide binding]; other site 1286640018137 conserved gate region; other site 1286640018138 putative PBP binding loops; other site 1286640018139 ABC-ATPase subunit interface; other site 1286640018140 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640018141 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640018142 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286640018143 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1286640018144 DNA interaction; other site 1286640018145 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640018146 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640018147 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640018148 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640018149 DNA binding site [nucleotide binding] 1286640018150 domain linker motif; other site 1286640018151 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1286640018152 ligand binding site [chemical binding]; other site 1286640018153 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1286640018154 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286640018155 Predicted transcriptional regulator [Transcription]; Region: COG4189 1286640018156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640018157 putative DNA binding site [nucleotide binding]; other site 1286640018158 dimerization interface [polypeptide binding]; other site 1286640018159 putative Zn2+ binding site [ion binding]; other site 1286640018160 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640018161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640018162 dimer interface [polypeptide binding]; other site 1286640018163 conserved gate region; other site 1286640018164 putative PBP binding loops; other site 1286640018165 ABC-ATPase subunit interface; other site 1286640018166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640018167 dimer interface [polypeptide binding]; other site 1286640018168 conserved gate region; other site 1286640018169 putative PBP binding loops; other site 1286640018170 ABC-ATPase subunit interface; other site 1286640018171 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640018172 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286640018173 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640018174 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640018175 Walker A/P-loop; other site 1286640018176 ATP binding site [chemical binding]; other site 1286640018177 Q-loop/lid; other site 1286640018178 ABC transporter signature motif; other site 1286640018179 Walker B; other site 1286640018180 D-loop; other site 1286640018181 H-loop/switch region; other site 1286640018182 TOBE domain; Region: TOBE_2; pfam08402 1286640018183 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1286640018184 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1286640018185 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1286640018186 Peptidase family M50; Region: Peptidase_M50; pfam02163 1286640018187 active site 1286640018188 putative substrate binding region [chemical binding]; other site 1286640018189 FOG: CBS domain [General function prediction only]; Region: COG0517 1286640018190 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 1286640018191 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1286640018192 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1286640018193 protein binding site [polypeptide binding]; other site 1286640018194 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1286640018195 Active site serine [active] 1286640018196 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640018197 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640018198 TM-ABC transporter signature motif; other site 1286640018199 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1286640018200 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640018201 Walker A/P-loop; other site 1286640018202 ATP binding site [chemical binding]; other site 1286640018203 Q-loop/lid; other site 1286640018204 ABC transporter signature motif; other site 1286640018205 Walker B; other site 1286640018206 D-loop; other site 1286640018207 H-loop/switch region; other site 1286640018208 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1286640018209 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286640018210 ligand binding site [chemical binding]; other site 1286640018211 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1286640018212 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1286640018213 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1286640018214 active site 1286640018215 catalytic residues [active] 1286640018216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640018217 PAS domain; Region: PAS_9; pfam13426 1286640018218 putative active site [active] 1286640018219 heme pocket [chemical binding]; other site 1286640018220 PAS domain S-box; Region: sensory_box; TIGR00229 1286640018221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640018222 putative active site [active] 1286640018223 heme pocket [chemical binding]; other site 1286640018224 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1286640018225 GAF domain; Region: GAF; pfam01590 1286640018226 PAS fold; Region: PAS_4; pfam08448 1286640018227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640018228 PAS fold; Region: PAS_3; pfam08447 1286640018229 putative active site [active] 1286640018230 heme pocket [chemical binding]; other site 1286640018231 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1286640018232 HWE histidine kinase; Region: HWE_HK; pfam07536 1286640018233 Response regulator receiver domain; Region: Response_reg; pfam00072 1286640018234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640018235 active site 1286640018236 phosphorylation site [posttranslational modification] 1286640018237 intermolecular recognition site; other site 1286640018238 dimerization interface [polypeptide binding]; other site 1286640018239 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286640018240 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640018241 non-specific DNA binding site [nucleotide binding]; other site 1286640018242 salt bridge; other site 1286640018243 sequence-specific DNA binding site [nucleotide binding]; other site 1286640018244 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1286640018245 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1286640018246 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1286640018247 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1286640018248 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1286640018249 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 1286640018250 active site 1286640018251 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1286640018252 Ligand Binding Site [chemical binding]; other site 1286640018253 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640018254 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1286640018255 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1286640018256 Walker A/P-loop; other site 1286640018257 ATP binding site [chemical binding]; other site 1286640018258 Q-loop/lid; other site 1286640018259 ABC transporter signature motif; other site 1286640018260 Walker B; other site 1286640018261 D-loop; other site 1286640018262 H-loop/switch region; other site 1286640018263 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1286640018264 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1286640018265 NAD binding site [chemical binding]; other site 1286640018266 homodimer interface [polypeptide binding]; other site 1286640018267 active site 1286640018268 substrate binding site [chemical binding]; other site 1286640018269 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1286640018270 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1286640018271 O-Antigen ligase; Region: Wzy_C; pfam04932 1286640018272 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1286640018273 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1286640018274 SLBB domain; Region: SLBB; pfam10531 1286640018275 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1286640018276 Exopolysaccharide production repressor; Region: SyrA; pfam11089 1286640018277 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286640018278 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286640018279 active site 1286640018280 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1286640018281 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1286640018282 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286640018283 active site 1286640018284 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1286640018285 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1286640018286 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1286640018287 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1286640018288 Catalytic site; other site 1286640018289 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1286640018290 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1286640018291 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1286640018292 active site 1286640018293 active site 1286640018294 catalytic residues [active] 1286640018295 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1286640018296 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 1286640018297 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1286640018298 Ligand binding site; other site 1286640018299 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1286640018300 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286640018301 active site 1286640018302 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286640018303 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1286640018304 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286640018305 active site 1286640018306 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1286640018307 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1286640018308 active site 1286640018309 tetramer interface; other site 1286640018310 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 1286640018311 Chain length determinant protein; Region: Wzz; pfam02706 1286640018312 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1286640018313 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1286640018314 substrate binding site [chemical binding]; other site 1286640018315 dimer interface [polypeptide binding]; other site 1286640018316 ATP binding site [chemical binding]; other site 1286640018317 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1286640018318 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1286640018319 dimer interface [polypeptide binding]; other site 1286640018320 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1286640018321 catalytic triad [active] 1286640018322 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286640018323 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286640018324 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1286640018325 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1286640018326 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1286640018327 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1286640018328 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640018329 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640018330 DNA binding site [nucleotide binding] 1286640018331 domain linker motif; other site 1286640018332 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1286640018333 ligand binding site [chemical binding]; other site 1286640018334 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1286640018335 Trehalase; Region: Trehalase; cl17346 1286640018336 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640018337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640018338 dimer interface [polypeptide binding]; other site 1286640018339 conserved gate region; other site 1286640018340 putative PBP binding loops; other site 1286640018341 ABC-ATPase subunit interface; other site 1286640018342 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640018343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640018344 dimer interface [polypeptide binding]; other site 1286640018345 conserved gate region; other site 1286640018346 putative PBP binding loops; other site 1286640018347 ABC-ATPase subunit interface; other site 1286640018348 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640018349 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640018350 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640018351 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640018352 Walker A/P-loop; other site 1286640018353 ATP binding site [chemical binding]; other site 1286640018354 Q-loop/lid; other site 1286640018355 ABC transporter signature motif; other site 1286640018356 Walker B; other site 1286640018357 D-loop; other site 1286640018358 H-loop/switch region; other site 1286640018359 TOBE domain; Region: TOBE_2; pfam08402 1286640018360 hypothetical protein; Provisional; Region: PRK06148 1286640018361 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1286640018362 active site 1286640018363 ATP binding site [chemical binding]; other site 1286640018364 substrate binding site [chemical binding]; other site 1286640018365 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286640018366 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286640018367 inhibitor-cofactor binding pocket; inhibition site 1286640018368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286640018369 catalytic residue [active] 1286640018370 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1286640018371 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1286640018372 NADP binding site [chemical binding]; other site 1286640018373 homodimer interface [polypeptide binding]; other site 1286640018374 active site 1286640018375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640018376 dimer interface [polypeptide binding]; other site 1286640018377 conserved gate region; other site 1286640018378 putative PBP binding loops; other site 1286640018379 ABC-ATPase subunit interface; other site 1286640018380 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286640018381 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640018382 substrate binding pocket [chemical binding]; other site 1286640018383 membrane-bound complex binding site; other site 1286640018384 hinge residues; other site 1286640018385 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640018386 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640018387 DNA binding site [nucleotide binding] 1286640018388 domain linker motif; other site 1286640018389 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1286640018390 ligand binding site [chemical binding]; other site 1286640018391 Acyl dehydratase [Lipid metabolism]; Region: MaoC; COG2030 1286640018392 active site 2 [active] 1286640018393 active site 1 [active] 1286640018394 DctM-like transporters; Region: DctM; pfam06808 1286640018395 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1286640018396 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1286640018397 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1286640018398 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1286640018399 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1286640018400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640018401 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1286640018402 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1286640018403 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1286640018404 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1286640018405 [2Fe-2S] cluster binding site [ion binding]; other site 1286640018406 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1286640018407 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1286640018408 [4Fe-4S] binding site [ion binding]; other site 1286640018409 molybdopterin cofactor binding site; other site 1286640018410 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1286640018411 molybdopterin cofactor binding site; other site 1286640018412 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1286640018413 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 1286640018414 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1286640018415 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1286640018416 Uroporphyrinogen-III methylase [Coenzyme metabolism]; Region: CysG; COG0007 1286640018417 homodimer interface [polypeptide binding]; other site 1286640018418 active site 1286640018419 SAM binding site [chemical binding]; other site 1286640018420 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1286640018421 nudix motif; other site 1286640018422 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1286640018423 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1286640018424 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1286640018425 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 1286640018426 dimer interface [polypeptide binding]; other site 1286640018427 active site residues [active] 1286640018428 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1286640018429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1286640018430 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1286640018431 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286640018432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1286640018433 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1286640018434 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1286640018435 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286640018436 active site 1286640018437 Predicted transcriptional regulator [Transcription]; Region: COG1959 1286640018438 Transcriptional regulator; Region: Rrf2; pfam02082 1286640018439 GTP-binding protein Der; Reviewed; Region: PRK00093 1286640018440 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1286640018441 G1 box; other site 1286640018442 GTP/Mg2+ binding site [chemical binding]; other site 1286640018443 Switch I region; other site 1286640018444 G2 box; other site 1286640018445 Switch II region; other site 1286640018446 G3 box; other site 1286640018447 G4 box; other site 1286640018448 G5 box; other site 1286640018449 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1286640018450 G1 box; other site 1286640018451 GTP/Mg2+ binding site [chemical binding]; other site 1286640018452 Switch I region; other site 1286640018453 G2 box; other site 1286640018454 G3 box; other site 1286640018455 Switch II region; other site 1286640018456 G4 box; other site 1286640018457 G5 box; other site 1286640018458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 1286640018459 Predicted membrane protein [Function unknown]; Region: COG4094 1286640018460 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 1286640018461 NodB motif; other site 1286640018462 putative active site [active] 1286640018463 putative catalytic site [active] 1286640018464 microcin B17 transporter; Reviewed; Region: PRK11098 1286640018465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640018466 putative substrate translocation pore; other site 1286640018467 D-galactonate transporter; Region: 2A0114; TIGR00893 1286640018468 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1286640018469 active site 1286640018470 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1286640018471 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1286640018472 Uncharacterized conserved protein [Function unknown]; Region: COG5649 1286640018473 Uncharacterized conserved protein [Function unknown]; Region: COG5649 1286640018474 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1286640018475 putative hydrophobic ligand binding site [chemical binding]; other site 1286640018476 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640018477 dimerization interface [polypeptide binding]; other site 1286640018478 putative DNA binding site [nucleotide binding]; other site 1286640018479 putative Zn2+ binding site [ion binding]; other site 1286640018480 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1286640018481 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1286640018482 N- and C-terminal domain interface [polypeptide binding]; other site 1286640018483 active site 1286640018484 MgATP binding site [chemical binding]; other site 1286640018485 catalytic site [active] 1286640018486 metal binding site [ion binding]; metal-binding site 1286640018487 glycerol binding site [chemical binding]; other site 1286640018488 homotetramer interface [polypeptide binding]; other site 1286640018489 homodimer interface [polypeptide binding]; other site 1286640018490 FBP binding site [chemical binding]; other site 1286640018491 protein IIAGlc interface [polypeptide binding]; other site 1286640018492 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1286640018493 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1286640018494 NAD binding site [chemical binding]; other site 1286640018495 homotetramer interface [polypeptide binding]; other site 1286640018496 homodimer interface [polypeptide binding]; other site 1286640018497 substrate binding site [chemical binding]; other site 1286640018498 active site 1286640018499 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 1286640018500 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640018501 catalytic loop [active] 1286640018502 iron binding site [ion binding]; other site 1286640018503 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1286640018504 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1286640018505 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 1286640018506 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1286640018507 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1286640018508 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1286640018509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640018510 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1286640018511 dimerization interface [polypeptide binding]; other site 1286640018512 substrate binding pocket [chemical binding]; other site 1286640018513 Predicted membrane protein [Function unknown]; Region: COG3748 1286640018514 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1286640018515 Cytochrome c; Region: Cytochrom_C; pfam00034 1286640018516 guanine deaminase; Provisional; Region: PRK09228 1286640018517 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1286640018518 active site 1286640018519 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1286640018520 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1286640018521 active site 1286640018522 substrate binding site [chemical binding]; other site 1286640018523 FMN binding site [chemical binding]; other site 1286640018524 putative catalytic residues [active] 1286640018525 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286640018526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1286640018527 DNA binding residues [nucleotide binding] 1286640018528 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286640018529 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1286640018530 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 1286640018531 N- and C-terminal domain interface [polypeptide binding]; other site 1286640018532 active site 1286640018533 MgATP binding site [chemical binding]; other site 1286640018534 catalytic site [active] 1286640018535 metal binding site [ion binding]; metal-binding site 1286640018536 putative carbohydrate binding site [chemical binding]; other site 1286640018537 putative homodimer interface [polypeptide binding]; other site 1286640018538 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286640018539 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1286640018540 putative NAD(P) binding site [chemical binding]; other site 1286640018541 catalytic Zn binding site [ion binding]; other site 1286640018542 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640018543 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640018544 TM-ABC transporter signature motif; other site 1286640018545 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640018546 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640018547 Walker A/P-loop; other site 1286640018548 ATP binding site [chemical binding]; other site 1286640018549 Q-loop/lid; other site 1286640018550 ABC transporter signature motif; other site 1286640018551 Walker B; other site 1286640018552 D-loop; other site 1286640018553 H-loop/switch region; other site 1286640018554 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640018555 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 1286640018556 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286640018557 putative ligand binding site [chemical binding]; other site 1286640018558 glucose-6-phosphate isomerase; Provisional; Region: PRK04190 1286640018559 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 1286640018560 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1286640018561 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1286640018562 FMN binding site [chemical binding]; other site 1286640018563 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286640018564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640018565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286640018566 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286640018567 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1286640018568 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286640018569 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1286640018570 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286640018571 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1286640018572 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1286640018573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640018574 NAD(P) binding site [chemical binding]; other site 1286640018575 active site 1286640018576 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286640018577 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1286640018578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640018579 PAS fold; Region: PAS_3; pfam08447 1286640018580 putative active site [active] 1286640018581 heme pocket [chemical binding]; other site 1286640018582 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640018583 PAS domain; Region: PAS_9; pfam13426 1286640018584 putative active site [active] 1286640018585 heme pocket [chemical binding]; other site 1286640018586 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640018587 PAS fold; Region: PAS_3; pfam08447 1286640018588 putative active site [active] 1286640018589 heme pocket [chemical binding]; other site 1286640018590 PAS fold; Region: PAS_3; pfam08447 1286640018591 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286640018592 putative active site [active] 1286640018593 heme pocket [chemical binding]; other site 1286640018594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640018595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640018596 ATP binding site [chemical binding]; other site 1286640018597 Mg2+ binding site [ion binding]; other site 1286640018598 G-X-G motif; other site 1286640018599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640018600 active site 1286640018601 phosphorylation site [posttranslational modification] 1286640018602 intermolecular recognition site; other site 1286640018603 dimerization interface [polypeptide binding]; other site 1286640018604 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1286640018605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640018606 active site 1286640018607 phosphorylation site [posttranslational modification] 1286640018608 intermolecular recognition site; other site 1286640018609 dimerization interface [polypeptide binding]; other site 1286640018610 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640018611 DNA binding residues [nucleotide binding] 1286640018612 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640018613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640018614 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1286640018615 putative effector binding pocket; other site 1286640018616 dimerization interface [polypeptide binding]; other site 1286640018617 short chain dehydrogenase; Provisional; Region: PRK06500 1286640018618 classical (c) SDRs; Region: SDR_c; cd05233 1286640018619 NAD(P) binding site [chemical binding]; other site 1286640018620 active site 1286640018621 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1286640018622 active site 1286640018623 homotetramer interface [polypeptide binding]; other site 1286640018624 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1286640018625 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1286640018626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1286640018627 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1286640018628 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1286640018629 active site 1286640018630 catalytic site [active] 1286640018631 tetramer interface [polypeptide binding]; other site 1286640018632 Protein of unknown function (DUF1045); Region: DUF1045; pfam06299 1286640018633 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286640018634 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1286640018635 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1286640018636 Protein required for attachment to host cells [Cell motility and secretion]; Region: COG5622 1286640018637 helicase 45; Provisional; Region: PTZ00424 1286640018638 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1286640018639 ATP binding site [chemical binding]; other site 1286640018640 Mg++ binding site [ion binding]; other site 1286640018641 motif III; other site 1286640018642 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286640018643 nucleotide binding region [chemical binding]; other site 1286640018644 ATP-binding site [chemical binding]; other site 1286640018645 Predicted metal-binding protein [General function prediction only]; Region: COG3019 1286640018646 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1286640018647 YtkA-like; Region: YtkA; pfam13115 1286640018648 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286640018649 EamA-like transporter family; Region: EamA; pfam00892 1286640018650 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1286640018651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1286640018652 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1286640018653 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1286640018654 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1286640018655 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1286640018656 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1286640018657 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1286640018658 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286640018659 NAD(P) binding site [chemical binding]; other site 1286640018660 catalytic residues [active] 1286640018661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1286640018662 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1286640018663 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640018664 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640018665 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640018666 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640018667 TM-ABC transporter signature motif; other site 1286640018668 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640018669 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640018670 Walker A/P-loop; other site 1286640018671 ATP binding site [chemical binding]; other site 1286640018672 Q-loop/lid; other site 1286640018673 ABC transporter signature motif; other site 1286640018674 Walker B; other site 1286640018675 D-loop; other site 1286640018676 H-loop/switch region; other site 1286640018677 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640018678 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1286640018679 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1286640018680 putative ligand binding site [chemical binding]; other site 1286640018681 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640018682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640018683 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1286640018684 putative dimerization interface [polypeptide binding]; other site 1286640018685 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286640018686 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286640018687 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286640018688 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1286640018689 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1286640018690 PAS domain S-box; Region: sensory_box; TIGR00229 1286640018691 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286640018692 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286640018693 metal binding site [ion binding]; metal-binding site 1286640018694 active site 1286640018695 I-site; other site 1286640018696 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640018697 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640018698 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1286640018699 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286640018700 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286640018701 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1286640018702 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1286640018703 putative ligand binding site [chemical binding]; other site 1286640018704 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640018705 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640018706 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640018707 TM-ABC transporter signature motif; other site 1286640018708 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1286640018709 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640018710 Walker A/P-loop; other site 1286640018711 ATP binding site [chemical binding]; other site 1286640018712 Q-loop/lid; other site 1286640018713 ABC transporter signature motif; other site 1286640018714 Walker B; other site 1286640018715 D-loop; other site 1286640018716 H-loop/switch region; other site 1286640018717 Homeodomain-like domain; Region: HTH_23; cl17451 1286640018718 putative transposase OrfB; Reviewed; Region: PHA02517 1286640018719 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640018720 Integrase core domain; Region: rve; pfam00665 1286640018721 Integrase core domain; Region: rve_3; pfam13683 1286640018722 Predicted small integral membrane protein [Function unknown]; Region: COG5478 1286640018723 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1286640018724 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1286640018725 active site 1286640018726 DNA binding site [nucleotide binding] 1286640018727 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1286640018728 DNA binding site [nucleotide binding] 1286640018729 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 1286640018730 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1286640018731 Sulfatase; Region: Sulfatase; pfam00884 1286640018732 Transposase; Region: HTH_Tnp_1; cl17663 1286640018733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286640018734 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 1286640018735 HTH-like domain; Region: HTH_21; pfam13276 1286640018736 Integrase core domain; Region: rve; pfam00665 1286640018737 Integrase core domain; Region: rve_3; pfam13683 1286640018738 Predicted chitinase [General function prediction only]; Region: COG3179 1286640018739 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286640018740 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1286640018741 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 1286640018742 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1286640018743 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1286640018744 catalytic triad [active] 1286640018745 dimer interface [polypeptide binding]; other site 1286640018746 conserved cis-peptide bond; other site 1286640018747 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 1286640018748 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1286640018749 putative DNA binding site [nucleotide binding]; other site 1286640018750 putative homodimer interface [polypeptide binding]; other site 1286640018751 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 1286640018752 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1286640018753 putative DNA binding site [nucleotide binding]; other site 1286640018754 putative homodimer interface [polypeptide binding]; other site 1286640018755 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286640018756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640018757 S-adenosylmethionine binding site [chemical binding]; other site 1286640018758 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1286640018759 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1286640018760 Ca2+ binding site [ion binding]; other site 1286640018761 tyrosine decarboxylase; Region: PLN02880 1286640018762 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1286640018763 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286640018764 catalytic residue [active] 1286640018765 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286640018766 FAD binding domain; Region: FAD_binding_4; pfam01565 1286640018767 Berberine and berberine like; Region: BBE; pfam08031 1286640018768 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1286640018769 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1286640018770 substrate binding site; other site 1286640018771 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1286640018772 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1286640018773 NAD binding site [chemical binding]; other site 1286640018774 homotetramer interface [polypeptide binding]; other site 1286640018775 homodimer interface [polypeptide binding]; other site 1286640018776 substrate binding site [chemical binding]; other site 1286640018777 active site 1286640018778 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1286640018779 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286640018780 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1286640018781 S-adenosylmethionine binding site [chemical binding]; other site 1286640018782 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1286640018783 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286640018784 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640018785 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640018786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640018787 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 1286640018788 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 1286640018789 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1286640018790 substrate binding site [chemical binding]; other site 1286640018791 trimer interface [polypeptide binding]; other site 1286640018792 Mn binding site [ion binding]; other site 1286640018793 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640018794 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1286640018795 ligand binding site [chemical binding]; other site 1286640018796 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640018797 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640018798 Walker A/P-loop; other site 1286640018799 ATP binding site [chemical binding]; other site 1286640018800 Q-loop/lid; other site 1286640018801 ABC transporter signature motif; other site 1286640018802 Walker B; other site 1286640018803 D-loop; other site 1286640018804 H-loop/switch region; other site 1286640018805 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640018806 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640018807 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640018808 TM-ABC transporter signature motif; other site 1286640018809 Predicted acyl esterases [General function prediction only]; Region: COG2936 1286640018810 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1286640018811 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 1286640018812 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1286640018813 extended (e) SDRs; Region: SDR_e; cd08946 1286640018814 NAD(P) binding site [chemical binding]; other site 1286640018815 active site 1286640018816 substrate binding site [chemical binding]; other site 1286640018817 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1286640018818 putative trimer interface [polypeptide binding]; other site 1286640018819 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1286640018820 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1286640018821 trimer interface [polypeptide binding]; other site 1286640018822 active site 1286640018823 substrate binding site [chemical binding]; other site 1286640018824 putative CoA binding site [chemical binding]; other site 1286640018825 CoA binding site [chemical binding]; other site 1286640018826 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1286640018827 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1286640018828 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286640018829 Walker A/P-loop; other site 1286640018830 ATP binding site [chemical binding]; other site 1286640018831 Q-loop/lid; other site 1286640018832 ABC transporter signature motif; other site 1286640018833 Walker B; other site 1286640018834 D-loop; other site 1286640018835 H-loop/switch region; other site 1286640018836 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1286640018837 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286640018838 ABC-ATPase subunit interface; other site 1286640018839 dimer interface [polypeptide binding]; other site 1286640018840 putative PBP binding regions; other site 1286640018841 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1286640018842 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1286640018843 putative ligand binding residues [chemical binding]; other site 1286640018844 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286640018845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640018846 S-adenosylmethionine binding site [chemical binding]; other site 1286640018847 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640018848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640018849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286640018850 dimerization interface [polypeptide binding]; other site 1286640018851 allantoate amidohydrolase; Reviewed; Region: PRK12893 1286640018852 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1286640018853 active site 1286640018854 metal binding site [ion binding]; metal-binding site 1286640018855 dimer interface [polypeptide binding]; other site 1286640018856 DctM-like transporters; Region: DctM; pfam06808 1286640018857 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1286640018858 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1286640018859 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1286640018860 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1286640018861 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286640018862 homotrimer interaction site [polypeptide binding]; other site 1286640018863 putative active site [active] 1286640018864 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 1286640018865 FOG: CBS domain [General function prediction only]; Region: COG0517 1286640018866 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1286640018867 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1286640018868 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1286640018869 BON domain; Region: BON; pfam04972 1286640018870 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1286640018871 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1286640018872 active site 1286640018873 DNA binding site [nucleotide binding] 1286640018874 Int/Topo IB signature motif; other site 1286640018875 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1286640018876 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1286640018877 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1286640018878 active site 1286640018879 catalytic site [active] 1286640018880 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1286640018881 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1286640018882 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1286640018883 catalytic site [active] 1286640018884 active site 1286640018885 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1286640018886 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1286640018887 Fe-S cluster binding site [ion binding]; other site 1286640018888 active site 1286640018889 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 1286640018890 glutathione s-transferase; Provisional; Region: PTZ00057 1286640018891 GSH binding site (G-site) [chemical binding]; other site 1286640018892 C-terminal domain interface [polypeptide binding]; other site 1286640018893 dimer interface [polypeptide binding]; other site 1286640018894 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 1286640018895 N-terminal domain interface [polypeptide binding]; other site 1286640018896 substrate binding pocket (H-site) [chemical binding]; other site 1286640018897 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1286640018898 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1286640018899 Uncharacterized conserved protein [Function unknown]; Region: COG1415 1286640018900 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640018901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640018902 dimer interface [polypeptide binding]; other site 1286640018903 conserved gate region; other site 1286640018904 putative PBP binding loops; other site 1286640018905 ABC-ATPase subunit interface; other site 1286640018906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640018907 dimer interface [polypeptide binding]; other site 1286640018908 conserved gate region; other site 1286640018909 putative PBP binding loops; other site 1286640018910 ABC-ATPase subunit interface; other site 1286640018911 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1286640018912 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640018913 Walker A/P-loop; other site 1286640018914 ATP binding site [chemical binding]; other site 1286640018915 Q-loop/lid; other site 1286640018916 ABC transporter signature motif; other site 1286640018917 Walker B; other site 1286640018918 D-loop; other site 1286640018919 H-loop/switch region; other site 1286640018920 TOBE domain; Region: TOBE_2; pfam08402 1286640018921 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640018922 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640018923 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286640018924 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1286640018925 substrate binding site [chemical binding]; other site 1286640018926 ATP binding site [chemical binding]; other site 1286640018927 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1286640018928 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1286640018929 NAD binding site [chemical binding]; other site 1286640018930 sugar binding site [chemical binding]; other site 1286640018931 divalent metal binding site [ion binding]; other site 1286640018932 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286640018933 dimer interface [polypeptide binding]; other site 1286640018934 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1286640018935 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640018936 DNA-binding site [nucleotide binding]; DNA binding site 1286640018937 UTRA domain; Region: UTRA; pfam07702 1286640018938 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1286640018939 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640018940 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640018941 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1286640018942 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286640018943 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1286640018944 Walker A/P-loop; other site 1286640018945 ATP binding site [chemical binding]; other site 1286640018946 Q-loop/lid; other site 1286640018947 ABC transporter signature motif; other site 1286640018948 Walker B; other site 1286640018949 D-loop; other site 1286640018950 H-loop/switch region; other site 1286640018951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 1286640018952 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1286640018953 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1286640018954 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1286640018955 Predicted small integral membrane protein [Function unknown]; Region: COG5478 1286640018956 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640018957 classical (c) SDRs; Region: SDR_c; cd05233 1286640018958 NAD(P) binding site [chemical binding]; other site 1286640018959 active site 1286640018960 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1286640018961 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1286640018962 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286640018963 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286640018964 putative active site [active] 1286640018965 putative NTP binding site [chemical binding]; other site 1286640018966 putative nucleic acid binding site [nucleotide binding]; other site 1286640018967 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1286640018968 Protein of unknown function (DUF982); Region: DUF982; pfam06169 1286640018969 FOG: CBS domain [General function prediction only]; Region: COG0517 1286640018970 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1286640018971 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1286640018972 RNA polymerase sigma factor; Provisional; Region: PRK12547 1286640018973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286640018974 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640018975 DNA binding residues [nucleotide binding] 1286640018976 metabolite-proton symporter; Region: 2A0106; TIGR00883 1286640018977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640018978 putative substrate translocation pore; other site 1286640018979 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1286640018980 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1286640018981 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1286640018982 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1286640018983 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1286640018984 D-pathway; other site 1286640018985 Putative ubiquinol binding site [chemical binding]; other site 1286640018986 Low-spin heme (heme b) binding site [chemical binding]; other site 1286640018987 Putative water exit pathway; other site 1286640018988 Binuclear center (heme o3/CuB) [ion binding]; other site 1286640018989 K-pathway; other site 1286640018990 Putative proton exit pathway; other site 1286640018991 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1286640018992 Subunit I/III interface [polypeptide binding]; other site 1286640018993 Subunit III/IV interface [polypeptide binding]; other site 1286640018994 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1286640018995 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1286640018996 Protein of unknown function (DUF992); Region: DUF992; pfam06186 1286640018997 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664 1286640018998 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286640018999 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1286640019000 putative DNA binding site [nucleotide binding]; other site 1286640019001 putative Zn2+ binding site [ion binding]; other site 1286640019002 AsnC family; Region: AsnC_trans_reg; pfam01037 1286640019003 ornithine cyclodeaminase; Validated; Region: PRK07589 1286640019004 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1286640019005 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1286640019006 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286640019007 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640019008 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640019009 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1286640019010 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286640019011 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1286640019012 active site 1286640019013 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640019014 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 1286640019015 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286640019016 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1286640019017 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1286640019018 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 1286640019019 putative active site [active] 1286640019020 putative metal binding site [ion binding]; other site 1286640019021 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1286640019022 O-Antigen ligase; Region: Wzy_C; pfam04932 1286640019023 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1286640019024 Chain length determinant protein; Region: Wzz; cl15801 1286640019025 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286640019026 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286640019027 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1286640019028 inhibitor site; inhibition site 1286640019029 active site 1286640019030 dimer interface [polypeptide binding]; other site 1286640019031 catalytic residue [active] 1286640019032 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1286640019033 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1286640019034 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1286640019035 homodimer interface [polypeptide binding]; other site 1286640019036 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1286640019037 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1286640019038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286640019039 S-adenosylmethionine binding site [chemical binding]; other site 1286640019040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286640019041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1286640019042 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286640019043 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286640019044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1286640019045 Histidine kinase; Region: HisKA_3; pfam07730 1286640019046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640019047 ATP binding site [chemical binding]; other site 1286640019048 Mg2+ binding site [ion binding]; other site 1286640019049 G-X-G motif; other site 1286640019050 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286640019051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640019052 active site 1286640019053 phosphorylation site [posttranslational modification] 1286640019054 intermolecular recognition site; other site 1286640019055 dimerization interface [polypeptide binding]; other site 1286640019056 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640019057 DNA binding residues [nucleotide binding] 1286640019058 dimerization interface [polypeptide binding]; other site 1286640019059 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1286640019060 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1286640019061 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1286640019062 Switch I; other site 1286640019063 Switch II; other site 1286640019064 septum formation inhibitor; Reviewed; Region: minC; PRK05177 1286640019065 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1286640019066 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640019067 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640019068 active site 1286640019069 catalytic tetrad [active] 1286640019070 NAD synthetase; Reviewed; Region: nadE; PRK00876 1286640019071 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1286640019072 homodimer interface [polypeptide binding]; other site 1286640019073 NAD binding pocket [chemical binding]; other site 1286640019074 ATP binding pocket [chemical binding]; other site 1286640019075 Mg binding site [ion binding]; other site 1286640019076 active-site loop [active] 1286640019077 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1286640019078 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286640019079 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 1286640019080 acyl-activating enzyme (AAE) consensus motif; other site 1286640019081 putative AMP binding site [chemical binding]; other site 1286640019082 putative active site [active] 1286640019083 putative CoA binding site [chemical binding]; other site 1286640019084 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1286640019085 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1286640019086 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1286640019087 active site 1286640019088 dimer interface [polypeptide binding]; other site 1286640019089 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1286640019090 Ligand Binding Site [chemical binding]; other site 1286640019091 Molecular Tunnel; other site 1286640019092 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1286640019093 dimer interface [polypeptide binding]; other site 1286640019094 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286640019095 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286640019096 active site 1286640019097 catalytic tetrad [active] 1286640019098 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640019099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640019100 dimer interface [polypeptide binding]; other site 1286640019101 conserved gate region; other site 1286640019102 putative PBP binding loops; other site 1286640019103 ABC-ATPase subunit interface; other site 1286640019104 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286640019105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640019106 dimer interface [polypeptide binding]; other site 1286640019107 conserved gate region; other site 1286640019108 putative PBP binding loops; other site 1286640019109 ABC-ATPase subunit interface; other site 1286640019110 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640019111 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640019112 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640019113 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640019114 Walker A/P-loop; other site 1286640019115 ATP binding site [chemical binding]; other site 1286640019116 Q-loop/lid; other site 1286640019117 ABC transporter signature motif; other site 1286640019118 Walker B; other site 1286640019119 D-loop; other site 1286640019120 H-loop/switch region; other site 1286640019121 TOBE domain; Region: TOBE; pfam03459 1286640019122 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286640019123 classical (c) SDRs; Region: SDR_c; cd05233 1286640019124 NAD(P) binding site [chemical binding]; other site 1286640019125 active site 1286640019126 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286640019127 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1286640019128 putative NAD(P) binding site [chemical binding]; other site 1286640019129 active site 1286640019130 putative substrate binding site [chemical binding]; other site 1286640019131 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286640019132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640019133 DNA-binding site [nucleotide binding]; DNA binding site 1286640019134 FCD domain; Region: FCD; pfam07729 1286640019135 putative aldolase; Validated; Region: PRK08130 1286640019136 intersubunit interface [polypeptide binding]; other site 1286640019137 active site 1286640019138 Zn2+ binding site [ion binding]; other site 1286640019139 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640019140 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640019141 DNA binding site [nucleotide binding] 1286640019142 domain linker motif; other site 1286640019143 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1286640019144 putative dimerization interface [polypeptide binding]; other site 1286640019145 putative ligand binding site [chemical binding]; other site 1286640019146 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1286640019147 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286640019148 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1286640019149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1286640019150 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640019151 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 1286640019152 putative ligand binding site [chemical binding]; other site 1286640019153 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 1286640019154 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640019155 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640019156 TM-ABC transporter signature motif; other site 1286640019157 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640019158 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640019159 Walker A/P-loop; other site 1286640019160 ATP binding site [chemical binding]; other site 1286640019161 Q-loop/lid; other site 1286640019162 ABC transporter signature motif; other site 1286640019163 Walker B; other site 1286640019164 D-loop; other site 1286640019165 H-loop/switch region; other site 1286640019166 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640019167 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640019168 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640019169 DNA binding site [nucleotide binding] 1286640019170 domain linker motif; other site 1286640019171 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1286640019172 dimerization interface [polypeptide binding]; other site 1286640019173 ligand binding site [chemical binding]; other site 1286640019174 Uncharacterized conserved protein [Function unknown]; Region: COG3506 1286640019175 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 1286640019176 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1286640019177 ureidoglycolate hydrolase; Provisional; Region: PRK13395 1286640019178 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1286640019179 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1286640019180 MOFRL family; Region: MOFRL; pfam05161 1286640019181 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1286640019182 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286640019183 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1286640019184 glyoxylate carboligase; Provisional; Region: PRK11269 1286640019185 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286640019186 PYR/PP interface [polypeptide binding]; other site 1286640019187 dimer interface [polypeptide binding]; other site 1286640019188 TPP binding site [chemical binding]; other site 1286640019189 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286640019190 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1286640019191 TPP-binding site [chemical binding]; other site 1286640019192 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1286640019193 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286640019194 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286640019195 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1286640019196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640019197 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1286640019198 putative dimerization interface [polypeptide binding]; other site 1286640019199 putative substrate binding pocket [chemical binding]; other site 1286640019200 hypothetical protein; Provisional; Region: PRK11171 1286640019201 Cupin domain; Region: Cupin_2; pfam07883 1286640019202 Cupin domain; Region: Cupin_2; pfam07883 1286640019203 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 1286640019204 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1286640019205 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1286640019206 active site 1286640019207 DNA binding site [nucleotide binding] 1286640019208 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1286640019209 DNA binding site [nucleotide binding] 1286640019210 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1286640019211 nucleotide binding site [chemical binding]; other site 1286640019212 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 1286640019213 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1286640019214 putative DNA binding site [nucleotide binding]; other site 1286640019215 putative homodimer interface [polypeptide binding]; other site 1286640019216 TPR repeat; Region: TPR_11; pfam13414 1286640019217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640019218 binding surface 1286640019219 TPR motif; other site 1286640019220 TPR repeat; Region: TPR_11; pfam13414 1286640019221 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1286640019222 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1286640019223 putative catalytic site [active] 1286640019224 putative phosphate binding site [ion binding]; other site 1286640019225 active site 1286640019226 metal binding site A [ion binding]; metal-binding site 1286640019227 DNA binding site [nucleotide binding] 1286640019228 putative AP binding site [nucleotide binding]; other site 1286640019229 putative metal binding site B [ion binding]; other site 1286640019230 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1286640019231 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 1286640019232 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1286640019233 NADP binding site [chemical binding]; other site 1286640019234 homodimer interface [polypeptide binding]; other site 1286640019235 active site 1286640019236 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1286640019237 Uncharacterized conserved protein [Function unknown]; Region: COG5654 1286640019238 Uncharacterized conserved protein [Function unknown]; Region: COG5642 1286640019239 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1286640019240 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1286640019241 putative metal binding site [ion binding]; other site 1286640019242 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 1286640019243 putative dimer interface [polypeptide binding]; other site 1286640019244 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1286640019245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640019246 putative substrate translocation pore; other site 1286640019247 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1286640019248 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286640019249 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286640019250 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1286640019251 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1286640019252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640019253 NAD(P) binding site [chemical binding]; other site 1286640019254 active site 1286640019255 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640019256 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640019257 DNA binding site [nucleotide binding] 1286640019258 Predicted integral membrane protein [Function unknown]; Region: COG5616 1286640019259 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1286640019260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640019261 TPR motif; other site 1286640019262 binding surface 1286640019263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640019264 binding surface 1286640019265 TPR motif; other site 1286640019266 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1286640019267 substrate binding site [chemical binding]; other site 1286640019268 glycogen synthase; Provisional; Region: glgA; PRK00654 1286640019269 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1286640019270 ADP-binding pocket [chemical binding]; other site 1286640019271 homodimer interface [polypeptide binding]; other site 1286640019272 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286640019273 EamA-like transporter family; Region: EamA; pfam00892 1286640019274 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1286640019275 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640019276 substrate binding pocket [chemical binding]; other site 1286640019277 membrane-bound complex binding site; other site 1286640019278 hinge residues; other site 1286640019279 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640019280 cyclase homology domain; Region: CHD; cd07302 1286640019281 nucleotidyl binding site; other site 1286640019282 metal binding site [ion binding]; metal-binding site 1286640019283 dimer interface [polypeptide binding]; other site 1286640019284 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1286640019285 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1286640019286 DNA binding site [nucleotide binding] 1286640019287 active site 1286640019288 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1286640019289 active site 1286640019290 DNA binding site [nucleotide binding] 1286640019291 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1286640019292 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286640019293 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1286640019294 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 1286640019295 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640019296 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1286640019297 putative ligand binding site [chemical binding]; other site 1286640019298 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640019299 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640019300 Walker A/P-loop; other site 1286640019301 ATP binding site [chemical binding]; other site 1286640019302 Q-loop/lid; other site 1286640019303 ABC transporter signature motif; other site 1286640019304 Walker B; other site 1286640019305 D-loop; other site 1286640019306 H-loop/switch region; other site 1286640019307 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640019308 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640019309 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640019310 TM-ABC transporter signature motif; other site 1286640019311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640019312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640019313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286640019314 dimerization interface [polypeptide binding]; other site 1286640019315 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286640019316 EamA-like transporter family; Region: EamA; pfam00892 1286640019317 EamA-like transporter family; Region: EamA; pfam00892 1286640019318 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640019319 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640019320 DNA binding site [nucleotide binding] 1286640019321 domain linker motif; other site 1286640019322 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1286640019323 dimerization interface [polypeptide binding]; other site 1286640019324 ligand binding site [chemical binding]; other site 1286640019325 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640019326 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286640019327 Walker A/P-loop; other site 1286640019328 ATP binding site [chemical binding]; other site 1286640019329 Q-loop/lid; other site 1286640019330 ABC transporter signature motif; other site 1286640019331 Walker B; other site 1286640019332 D-loop; other site 1286640019333 H-loop/switch region; other site 1286640019334 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640019335 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640019336 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640019337 TM-ABC transporter signature motif; other site 1286640019338 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1286640019339 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 1286640019340 putative ligand binding site [chemical binding]; other site 1286640019341 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1286640019342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640019343 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640019344 dimer interface [polypeptide binding]; other site 1286640019345 phosphorylation site [posttranslational modification] 1286640019346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640019347 ATP binding site [chemical binding]; other site 1286640019348 Mg2+ binding site [ion binding]; other site 1286640019349 G-X-G motif; other site 1286640019350 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640019351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640019352 active site 1286640019353 phosphorylation site [posttranslational modification] 1286640019354 intermolecular recognition site; other site 1286640019355 dimerization interface [polypeptide binding]; other site 1286640019356 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286640019357 DNA binding site [nucleotide binding] 1286640019358 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286640019359 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1286640019360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1286640019361 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1286640019362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1286640019363 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1286640019364 glutamine synthetase; Region: PLN02284 1286640019365 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1286640019366 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1286640019367 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 1286640019368 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1286640019369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286640019370 motif II; other site 1286640019371 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286640019372 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1286640019373 active site 1286640019374 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1286640019375 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1286640019376 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1286640019377 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 1286640019378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286640019379 NAD(P) binding site [chemical binding]; other site 1286640019380 active site 1286640019381 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286640019382 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1286640019383 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1286640019384 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286640019385 substrate binding site [chemical binding]; other site 1286640019386 oxyanion hole (OAH) forming residues; other site 1286640019387 trimer interface [polypeptide binding]; other site 1286640019388 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1286640019389 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286640019390 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1286640019391 substrate binding pocket [chemical binding]; other site 1286640019392 FAD binding site [chemical binding]; other site 1286640019393 catalytic base [active] 1286640019394 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286640019395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286640019396 non-specific DNA binding site [nucleotide binding]; other site 1286640019397 salt bridge; other site 1286640019398 sequence-specific DNA binding site [nucleotide binding]; other site 1286640019399 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1286640019400 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1286640019401 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1286640019402 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1286640019403 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1286640019404 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1286640019405 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1286640019406 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286640019407 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1286640019408 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1286640019409 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1286640019410 carboxyltransferase (CT) interaction site; other site 1286640019411 biotinylation site [posttranslational modification]; other site 1286640019412 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1286640019413 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1286640019414 active site 1286640019415 substrate binding site [chemical binding]; other site 1286640019416 coenzyme B12 binding site [chemical binding]; other site 1286640019417 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1286640019418 B12 binding site [chemical binding]; other site 1286640019419 cobalt ligand [ion binding]; other site 1286640019420 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 1286640019421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640019422 DNA-binding site [nucleotide binding]; DNA binding site 1286640019423 UTRA domain; Region: UTRA; pfam07702 1286640019424 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1286640019425 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 1286640019426 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 1286640019427 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 1286640019428 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1286640019429 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640019430 Walker A/P-loop; other site 1286640019431 ATP binding site [chemical binding]; other site 1286640019432 Q-loop/lid; other site 1286640019433 ABC transporter signature motif; other site 1286640019434 Walker B; other site 1286640019435 D-loop; other site 1286640019436 H-loop/switch region; other site 1286640019437 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640019438 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1286640019439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640019440 Walker A/P-loop; other site 1286640019441 ATP binding site [chemical binding]; other site 1286640019442 Q-loop/lid; other site 1286640019443 ABC transporter signature motif; other site 1286640019444 Walker B; other site 1286640019445 D-loop; other site 1286640019446 H-loop/switch region; other site 1286640019447 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 1286640019448 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1286640019449 trimer interface [polypeptide binding]; other site 1286640019450 active site 1286640019451 substrate binding site [chemical binding]; other site 1286640019452 CoA binding site [chemical binding]; other site 1286640019453 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 1286640019454 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1286640019455 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286640019456 dihydroxyacetone kinase; Provisional; Region: PRK14479 1286640019457 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1286640019458 DAK2 domain; Region: Dak2; pfam02734 1286640019459 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1286640019460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1286640019461 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1286640019462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1286640019463 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1286640019464 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1286640019465 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286640019466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286640019467 DNA-binding site [nucleotide binding]; DNA binding site 1286640019468 FCD domain; Region: FCD; pfam07729 1286640019469 FecR protein; Region: FecR; pfam04773 1286640019470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640019471 TPR motif; other site 1286640019472 TPR repeat; Region: TPR_11; pfam13414 1286640019473 binding surface 1286640019474 TPR repeat; Region: TPR_11; pfam13414 1286640019475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640019476 binding surface 1286640019477 TPR motif; other site 1286640019478 TPR repeat; Region: TPR_11; pfam13414 1286640019479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286640019480 binding surface 1286640019481 TPR motif; other site 1286640019482 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1286640019483 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1286640019484 CHASE2 domain; Region: CHASE2; pfam05226 1286640019485 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1286640019486 cyclase homology domain; Region: CHD; cd07302 1286640019487 nucleotidyl binding site; other site 1286640019488 metal binding site [ion binding]; metal-binding site 1286640019489 dimer interface [polypeptide binding]; other site 1286640019490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286640019491 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286640019492 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286640019493 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1286640019494 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1286640019495 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1286640019496 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286640019497 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286640019498 putative active site [active] 1286640019499 putative NTP binding site [chemical binding]; other site 1286640019500 putative nucleic acid binding site [nucleotide binding]; other site 1286640019501 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1286640019502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1286640019503 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286640019504 Homeodomain-like domain; Region: HTH_32; pfam13565 1286640019505 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1286640019506 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1286640019507 Walker A/P-loop; other site 1286640019508 ATP binding site [chemical binding]; other site 1286640019509 Q-loop/lid; other site 1286640019510 ABC transporter signature motif; other site 1286640019511 Walker B; other site 1286640019512 D-loop; other site 1286640019513 H-loop/switch region; other site 1286640019514 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1286640019515 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1286640019516 Walker A/P-loop; other site 1286640019517 ATP binding site [chemical binding]; other site 1286640019518 Q-loop/lid; other site 1286640019519 ABC transporter signature motif; other site 1286640019520 Walker B; other site 1286640019521 D-loop; other site 1286640019522 H-loop/switch region; other site 1286640019523 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1286640019524 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640019525 TM-ABC transporter signature motif; other site 1286640019526 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1286640019527 TM-ABC transporter signature motif; other site 1286640019528 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1286640019529 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1286640019530 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1286640019531 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286640019532 Walker A/P-loop; other site 1286640019533 ATP binding site [chemical binding]; other site 1286640019534 Q-loop/lid; other site 1286640019535 ABC transporter signature motif; other site 1286640019536 Walker B; other site 1286640019537 D-loop; other site 1286640019538 H-loop/switch region; other site 1286640019539 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1286640019540 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286640019541 substrate binding pocket [chemical binding]; other site 1286640019542 membrane-bound complex binding site; other site 1286640019543 hinge residues; other site 1286640019544 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286640019545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640019546 dimer interface [polypeptide binding]; other site 1286640019547 conserved gate region; other site 1286640019548 putative PBP binding loops; other site 1286640019549 ABC-ATPase subunit interface; other site 1286640019550 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1286640019551 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1286640019552 active site 1286640019553 non-prolyl cis peptide bond; other site 1286640019554 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286640019555 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 1286640019556 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 1286640019557 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1286640019558 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1286640019559 active site 1286640019560 catalytic site [active] 1286640019561 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975 1286640019562 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1286640019563 tetramer interface [polypeptide binding]; other site 1286640019564 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1286640019565 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1286640019566 heterodimer interface [polypeptide binding]; other site 1286640019567 active site 1286640019568 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1286640019569 heterodimer interface [polypeptide binding]; other site 1286640019570 multimer interface [polypeptide binding]; other site 1286640019571 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1286640019572 active site 1286640019573 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1286640019574 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286640019575 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1286640019576 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1286640019577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640019578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286640019579 dimerization interface [polypeptide binding]; other site 1286640019580 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286640019581 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1286640019582 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1286640019583 dimer interface [polypeptide binding]; other site 1286640019584 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1286640019585 active site 1286640019586 Fe binding site [ion binding]; other site 1286640019587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286640019588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286640019589 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1286640019590 putative dimerization interface [polypeptide binding]; other site 1286640019591 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1286640019592 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1286640019593 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1286640019594 Moco binding site; other site 1286640019595 metal coordination site [ion binding]; other site 1286640019596 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1286640019597 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1286640019598 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1286640019599 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1286640019600 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286640019601 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1286640019602 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1286640019603 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1286640019604 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286640019605 dimer interface [polypeptide binding]; other site 1286640019606 active site 1286640019607 acylphosphatase; Provisional; Region: PRK14425 1286640019608 RNA polymerase sigma factor; Provisional; Region: PRK11922 1286640019609 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286640019610 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286640019611 DNA binding residues [nucleotide binding] 1286640019612 Predicted outer membrane protein [Function unknown]; Region: COG3652 1286640019613 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1286640019614 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1286640019615 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1286640019616 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1286640019617 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1286640019618 Predicted membrane protein [Function unknown]; Region: COG2259 1286640019619 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 1286640019620 MerR family regulatory protein; Region: MerR; pfam00376 1286640019621 DNA binding residues [nucleotide binding] 1286640019622 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1286640019623 P-loop; other site 1286640019624 Magnesium ion binding site [ion binding]; other site 1286640019625 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1286640019626 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1286640019627 Magnesium ion binding site [ion binding]; other site 1286640019628 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 1286640019629 ParB-like nuclease domain; Region: ParBc; pfam02195 1286640019630 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1286640019631 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1286640019632 Walker A/P-loop; other site 1286640019633 ATP binding site [chemical binding]; other site 1286640019634 Q-loop/lid; other site 1286640019635 ABC transporter signature motif; other site 1286640019636 Walker B; other site 1286640019637 D-loop; other site 1286640019638 H-loop/switch region; other site 1286640019639 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1286640019640 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1286640019641 Walker A/P-loop; other site 1286640019642 ATP binding site [chemical binding]; other site 1286640019643 Q-loop/lid; other site 1286640019644 ABC transporter signature motif; other site 1286640019645 Walker B; other site 1286640019646 D-loop; other site 1286640019647 H-loop/switch region; other site 1286640019648 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1286640019649 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1286640019650 TM-ABC transporter signature motif; other site 1286640019651 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1286640019652 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640019653 TM-ABC transporter signature motif; other site 1286640019654 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1286640019655 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1286640019656 putative ligand binding site [chemical binding]; other site 1286640019657 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1286640019658 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1286640019659 putative hydrophobic ligand binding site [chemical binding]; other site 1286640019660 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640019661 dimerization interface [polypeptide binding]; other site 1286640019662 putative DNA binding site [nucleotide binding]; other site 1286640019663 putative Zn2+ binding site [ion binding]; other site 1286640019664 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1286640019665 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286640019666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640019667 dimer interface [polypeptide binding]; other site 1286640019668 phosphorylation site [posttranslational modification] 1286640019669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640019670 ATP binding site [chemical binding]; other site 1286640019671 Mg2+ binding site [ion binding]; other site 1286640019672 G-X-G motif; other site 1286640019673 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1286640019674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640019675 active site 1286640019676 phosphorylation site [posttranslational modification] 1286640019677 intermolecular recognition site; other site 1286640019678 dimerization interface [polypeptide binding]; other site 1286640019679 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286640019680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640019681 active site 1286640019682 phosphorylation site [posttranslational modification] 1286640019683 intermolecular recognition site; other site 1286640019684 dimerization interface [polypeptide binding]; other site 1286640019685 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286640019686 DNA binding residues [nucleotide binding] 1286640019687 dimerization interface [polypeptide binding]; other site 1286640019688 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1286640019689 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1286640019690 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1286640019691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286640019692 dimer interface [polypeptide binding]; other site 1286640019693 phosphorylation site [posttranslational modification] 1286640019694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286640019695 ATP binding site [chemical binding]; other site 1286640019696 Mg2+ binding site [ion binding]; other site 1286640019697 G-X-G motif; other site 1286640019698 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1286640019699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286640019700 active site 1286640019701 phosphorylation site [posttranslational modification] 1286640019702 intermolecular recognition site; other site 1286640019703 dimerization interface [polypeptide binding]; other site 1286640019704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286640019705 Walker A motif; other site 1286640019706 ATP binding site [chemical binding]; other site 1286640019707 Walker B motif; other site 1286640019708 arginine finger; other site 1286640019709 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1286640019710 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1286640019711 ThiC-associated domain; Region: ThiC-associated; pfam13667 1286640019712 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1286640019713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286640019714 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1286640019715 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1286640019716 thiS-thiF/thiG interaction site; other site 1286640019717 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1286640019718 ThiS interaction site; other site 1286640019719 putative active site [active] 1286640019720 tetramer interface [polypeptide binding]; other site 1286640019721 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1286640019722 thiamine phosphate binding site [chemical binding]; other site 1286640019723 active site 1286640019724 pyrophosphate binding site [ion binding]; other site 1286640019725 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286640019726 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286640019727 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1286640019728 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286640019729 putative ligand binding site [chemical binding]; other site 1286640019730 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1286640019731 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286640019732 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286640019733 TM-ABC transporter signature motif; other site 1286640019734 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286640019735 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286640019736 Walker A/P-loop; other site 1286640019737 ATP binding site [chemical binding]; other site 1286640019738 Q-loop/lid; other site 1286640019739 ABC transporter signature motif; other site 1286640019740 Walker B; other site 1286640019741 D-loop; other site 1286640019742 H-loop/switch region; other site 1286640019743 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286640019744 Phosphotransferase enzyme family; Region: APH; pfam01636 1286640019745 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1286640019746 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1286640019747 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1286640019748 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286640019749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286640019750 putative substrate translocation pore; other site 1286640019751 Cupin; Region: Cupin_6; pfam12852 1286640019752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640019753 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640019754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640019755 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1286640019756 Predicted transcriptional regulator [Transcription]; Region: COG3905 1286640019757 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1286640019758 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286640019759 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286640019760 Walker A/P-loop; other site 1286640019761 ATP binding site [chemical binding]; other site 1286640019762 Q-loop/lid; other site 1286640019763 ABC transporter signature motif; other site 1286640019764 Walker B; other site 1286640019765 D-loop; other site 1286640019766 H-loop/switch region; other site 1286640019767 TOBE domain; Region: TOBE_2; pfam08402 1286640019768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1286640019769 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1286640019770 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286640019771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640019772 dimer interface [polypeptide binding]; other site 1286640019773 conserved gate region; other site 1286640019774 putative PBP binding loops; other site 1286640019775 ABC-ATPase subunit interface; other site 1286640019776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640019777 dimer interface [polypeptide binding]; other site 1286640019778 conserved gate region; other site 1286640019779 putative PBP binding loops; other site 1286640019780 ABC-ATPase subunit interface; other site 1286640019781 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286640019782 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286640019783 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640019784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286640019785 DNA binding site [nucleotide binding] 1286640019786 domain linker motif; other site 1286640019787 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1286640019788 dimerization interface [polypeptide binding]; other site 1286640019789 ligand binding site [chemical binding]; other site 1286640019790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286640019791 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286640019792 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286640019793 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1286640019794 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1286640019795 NAD(P) binding pocket [chemical binding]; other site 1286640019796 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1286640019797 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1286640019798 dimer interface [polypeptide binding]; other site 1286640019799 active site 1286640019800 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286640019801 catalytic residues [active] 1286640019802 substrate binding site [chemical binding]; other site 1286640019803 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1286640019804 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1286640019805 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286640019806 enoyl-CoA hydratase; Provisional; Region: PRK08140 1286640019807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286640019808 substrate binding site [chemical binding]; other site 1286640019809 oxyanion hole (OAH) forming residues; other site 1286640019810 trimer interface [polypeptide binding]; other site 1286640019811 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1286640019812 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1286640019813 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1286640019814 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1286640019815 substrate binding site [chemical binding]; other site 1286640019816 dimer interface [polypeptide binding]; other site 1286640019817 NADP binding site [chemical binding]; other site 1286640019818 catalytic residues [active] 1286640019819 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 1286640019820 substrate binding site [chemical binding]; other site 1286640019821 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1286640019822 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1286640019823 FAD binding pocket [chemical binding]; other site 1286640019824 FAD binding motif [chemical binding]; other site 1286640019825 phosphate binding motif [ion binding]; other site 1286640019826 beta-alpha-beta structure motif; other site 1286640019827 NAD(p) ribose binding residues [chemical binding]; other site 1286640019828 NAD binding pocket [chemical binding]; other site 1286640019829 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1286640019830 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286640019831 catalytic loop [active] 1286640019832 iron binding site [ion binding]; other site 1286640019833 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1286640019834 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1286640019835 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1286640019836 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1286640019837 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1286640019838 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1286640019839 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1286640019840 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 1286640019841 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286640019842 putative DNA binding site [nucleotide binding]; other site 1286640019843 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1286640019844 Protein of unknown function (DUF992); Region: DUF992; pfam06186 1286640019845 alpha-galactosidase; Provisional; Region: PRK15076 1286640019846 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1286640019847 NAD binding site [chemical binding]; other site 1286640019848 sugar binding site [chemical binding]; other site 1286640019849 divalent metal binding site [ion binding]; other site 1286640019850 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286640019851 dimer interface [polypeptide binding]; other site 1286640019852 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1286640019853 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640019854 Walker A/P-loop; other site 1286640019855 ATP binding site [chemical binding]; other site 1286640019856 Q-loop/lid; other site 1286640019857 ABC transporter signature motif; other site 1286640019858 Walker B; other site 1286640019859 D-loop; other site 1286640019860 H-loop/switch region; other site 1286640019861 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640019862 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286640019863 Walker A/P-loop; other site 1286640019864 ATP binding site [chemical binding]; other site 1286640019865 Q-loop/lid; other site 1286640019866 ABC transporter signature motif; other site 1286640019867 Walker B; other site 1286640019868 D-loop; other site 1286640019869 H-loop/switch region; other site 1286640019870 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286640019871 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286640019872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640019873 dimer interface [polypeptide binding]; other site 1286640019874 conserved gate region; other site 1286640019875 putative PBP binding loops; other site 1286640019876 ABC-ATPase subunit interface; other site 1286640019877 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286640019878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286640019879 dimer interface [polypeptide binding]; other site 1286640019880 conserved gate region; other site 1286640019881 putative PBP binding loops; other site 1286640019882 ABC-ATPase subunit interface; other site 1286640019883 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1286640019884 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1286640019885 alpha-galactosidase; Provisional; Region: PRK15076 1286640019886 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1286640019887 NAD binding site [chemical binding]; other site 1286640019888 sugar binding site [chemical binding]; other site 1286640019889 divalent metal binding site [ion binding]; other site 1286640019890 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286640019891 dimer interface [polypeptide binding]; other site 1286640019892 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1286640019893 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286640019894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286640019895 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286640019896 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1286640019897 putative dimerization interface [polypeptide binding]; other site 1286640019898 putative ligand binding site [chemical binding]; other site 1286640019899 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1286640019900 oligomeric interface; other site 1286640019901 putative active site [active] 1286640019902 homodimer interface [polypeptide binding]; other site