-- dump date 20140620_070452 -- class Genbank::misc_feature -- table misc_feature_note -- id note 693982000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 693982000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 693982000003 Bacterial dnaA protein; Region: Bac_DnaA; pfam00308 693982000004 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 693982000005 DnaA box-binding interface [nucleotide binding]; other site 693982000006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 693982000007 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 693982000008 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982000009 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 693982000010 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 693982000011 putative hydrophobic ligand binding site [chemical binding]; other site 693982000012 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 693982000013 SnoaL-like domain; Region: SnoaL_3; pfam13474 693982000014 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 693982000015 putative dimer interface [polypeptide binding]; other site 693982000016 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982000017 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 693982000018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693982000019 FeS/SAM binding site; other site 693982000020 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 693982000021 active site 693982000022 dimerization interface [polypeptide binding]; other site 693982000023 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 693982000024 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982000025 active site 693982000026 ribonuclease PH; Reviewed; Region: rph; PRK00173 693982000027 Ribonuclease PH; Region: RNase_PH_bact; cd11362 693982000028 hexamer interface [polypeptide binding]; other site 693982000029 active site 693982000030 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 693982000031 heat shock protein GrpE; Provisional; Region: PRK14141 693982000032 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 693982000033 dimer interface [polypeptide binding]; other site 693982000034 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 693982000035 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693982000036 active site 693982000037 phosphorylation site [posttranslational modification] 693982000038 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 693982000039 30S subunit binding site; other site 693982000040 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 693982000041 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 693982000042 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 693982000043 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 693982000044 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 693982000045 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 693982000046 Walker A/P-loop; other site 693982000047 ATP binding site [chemical binding]; other site 693982000048 Q-loop/lid; other site 693982000049 ABC transporter signature motif; other site 693982000050 Walker B; other site 693982000051 D-loop; other site 693982000052 H-loop/switch region; other site 693982000053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 693982000054 OstA-like protein; Region: OstA; pfam03968 693982000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 693982000056 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 693982000057 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 693982000058 tandem repeat interface [polypeptide binding]; other site 693982000059 oligomer interface [polypeptide binding]; other site 693982000060 active site residues [active] 693982000061 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693982000062 IHF dimer interface [polypeptide binding]; other site 693982000063 IHF - DNA interface [nucleotide binding]; other site 693982000064 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 693982000065 putative hydrophobic ligand binding site [chemical binding]; other site 693982000066 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 693982000067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982000068 S-adenosylmethionine binding site [chemical binding]; other site 693982000069 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 693982000070 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 693982000071 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693982000072 lipoprotein signal peptidase; Provisional; Region: PRK14795 693982000073 PAS domain; Region: PAS_9; pfam13426 693982000074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982000075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982000076 dimer interface [polypeptide binding]; other site 693982000077 phosphorylation site [posttranslational modification] 693982000078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982000079 ATP binding site [chemical binding]; other site 693982000080 Mg2+ binding site [ion binding]; other site 693982000081 G-X-G motif; other site 693982000082 Response regulator receiver domain; Region: Response_reg; pfam00072 693982000083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982000084 active site 693982000085 phosphorylation site [posttranslational modification] 693982000086 intermolecular recognition site; other site 693982000087 dimerization interface [polypeptide binding]; other site 693982000088 Putative hemolysin [General function prediction only]; Region: COG3176 693982000089 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 693982000090 Malic enzyme, N-terminal domain; Region: malic; pfam00390 693982000091 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 693982000092 putative NAD(P) binding site [chemical binding]; other site 693982000093 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 693982000094 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 693982000095 MutS domain I; Region: MutS_I; pfam01624 693982000096 MutS domain II; Region: MutS_II; pfam05188 693982000097 MutS domain III; Region: MutS_III; pfam05192 693982000098 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 693982000099 Walker A/P-loop; other site 693982000100 ATP binding site [chemical binding]; other site 693982000101 Q-loop/lid; other site 693982000102 ABC transporter signature motif; other site 693982000103 Walker B; other site 693982000104 D-loop; other site 693982000105 H-loop/switch region; other site 693982000106 PII uridylyl-transferase; Provisional; Region: PRK05092 693982000107 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693982000108 metal binding triad; other site 693982000109 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 693982000110 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693982000111 Zn2+ binding site [ion binding]; other site 693982000112 Mg2+ binding site [ion binding]; other site 693982000113 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693982000114 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 693982000115 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 693982000116 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 693982000117 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982000118 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 693982000119 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 693982000120 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 693982000121 active site 693982000122 HIGH motif; other site 693982000123 dimer interface [polypeptide binding]; other site 693982000124 KMSKS motif; other site 693982000125 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693982000126 Ligand Binding Site [chemical binding]; other site 693982000127 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 693982000128 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 693982000129 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 693982000130 Glycoprotease family; Region: Peptidase_M22; pfam00814 693982000131 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693982000132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982000133 Coenzyme A binding pocket [chemical binding]; other site 693982000134 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693982000135 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693982000136 putative acyl-acceptor binding pocket; other site 693982000137 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 693982000138 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693982000139 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693982000140 FeS/SAM binding site; other site 693982000141 TRAM domain; Region: TRAM; pfam01938 693982000142 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 693982000143 PhoH-like protein; Region: PhoH; pfam02562 693982000144 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 693982000145 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 693982000146 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693982000147 Transporter associated domain; Region: CorC_HlyC; smart01091 693982000148 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 693982000149 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 693982000150 putative active site [active] 693982000151 catalytic triad [active] 693982000152 putative dimer interface [polypeptide binding]; other site 693982000153 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982000154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982000155 non-specific DNA binding site [nucleotide binding]; other site 693982000156 salt bridge; other site 693982000157 sequence-specific DNA binding site [nucleotide binding]; other site 693982000158 S-adenosylmethionine synthetase; Validated; Region: PRK05250 693982000159 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 693982000160 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 693982000161 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 693982000162 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 693982000163 Uncharacterized small protein [Function unknown]; Region: COG5568 693982000164 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 693982000165 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 693982000166 putative dimer interface [polypeptide binding]; other site 693982000167 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 693982000168 active site 693982000169 tetramer interface [polypeptide binding]; other site 693982000170 Cache domain; Region: Cache_1; pfam02743 693982000171 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693982000172 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 693982000173 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693982000174 dimer interface [polypeptide binding]; other site 693982000175 putative CheW interface [polypeptide binding]; other site 693982000176 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693982000177 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 693982000178 substrate binding site [chemical binding]; other site 693982000179 dimer interface [polypeptide binding]; other site 693982000180 ATP binding site [chemical binding]; other site 693982000181 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 693982000182 RmuC family; Region: RmuC; pfam02646 693982000183 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 693982000184 active site 693982000185 catalytic residues [active] 693982000186 metal binding site [ion binding]; metal-binding site 693982000187 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 693982000188 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 693982000189 putative active site [active] 693982000190 substrate binding site [chemical binding]; other site 693982000191 putative cosubstrate binding site; other site 693982000192 catalytic site [active] 693982000193 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 693982000194 substrate binding site [chemical binding]; other site 693982000195 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 693982000196 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 693982000197 dimerization interface 3.5A [polypeptide binding]; other site 693982000198 active site 693982000199 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 693982000200 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 693982000201 metal binding site [ion binding]; metal-binding site 693982000202 dimer interface [polypeptide binding]; other site 693982000203 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 693982000204 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693982000205 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982000206 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982000207 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 693982000208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982000209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982000210 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 693982000211 putative effector binding pocket; other site 693982000212 putative dimerization interface [polypeptide binding]; other site 693982000213 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 693982000214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693982000215 ATP binding site [chemical binding]; other site 693982000216 putative Mg++ binding site [ion binding]; other site 693982000217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693982000218 nucleotide binding region [chemical binding]; other site 693982000219 ATP-binding site [chemical binding]; other site 693982000220 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 693982000221 RNA binding site [nucleotide binding]; other site 693982000222 Predicted membrane protein [Function unknown]; Region: COG3152 693982000223 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 693982000224 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 693982000225 trimer interface [polypeptide binding]; other site 693982000226 active site 693982000227 substrate binding site [chemical binding]; other site 693982000228 CoA binding site [chemical binding]; other site 693982000229 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 693982000230 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 693982000231 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 693982000232 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 693982000233 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 693982000234 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693982000235 DNA binding site [nucleotide binding] 693982000236 active site 693982000237 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 693982000238 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693982000239 tetramer interface [polypeptide binding]; other site 693982000240 active site 693982000241 Mg2+/Mn2+ binding site [ion binding]; other site 693982000242 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 693982000243 homohexameric interface [polypeptide binding]; other site 693982000244 feedback inhibition sensing region; other site 693982000245 carbamate kinase; Reviewed; Region: PRK12686 693982000246 nucleotide binding site [chemical binding]; other site 693982000247 N-acetyl-L-glutamate binding site [chemical binding]; other site 693982000248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 693982000249 Anti-sigma-K factor rskA; Region: RskA; pfam10099 693982000250 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 693982000251 SelR domain; Region: SelR; pfam01641 693982000252 Predicted membrane protein [Function unknown]; Region: COG4803 693982000253 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 693982000254 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 693982000255 G1 box; other site 693982000256 GTP/Mg2+ binding site [chemical binding]; other site 693982000257 Switch I region; other site 693982000258 G2 box; other site 693982000259 G3 box; other site 693982000260 Switch II region; other site 693982000261 G4 box; other site 693982000262 G5 box; other site 693982000263 membrane protein insertase; Provisional; Region: PRK01318 693982000264 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 693982000265 ribonuclease P; Reviewed; Region: rnpA; PRK01313 693982000266 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 693982000267 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693982000268 dimerization interface [polypeptide binding]; other site 693982000269 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693982000270 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693982000271 dimer interface [polypeptide binding]; other site 693982000272 putative CheW interface [polypeptide binding]; other site 693982000273 Uncharacterized conserved protein [Function unknown]; Region: COG0398 693982000274 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 693982000275 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 693982000276 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693982000277 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982000278 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693982000279 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982000280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982000281 ATP binding site [chemical binding]; other site 693982000282 Mg2+ binding site [ion binding]; other site 693982000283 G-X-G motif; other site 693982000284 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 693982000285 Protein of unknown function (DUF497); Region: DUF497; cl01108 693982000286 replicative DNA helicase; Provisional; Region: PRK05973 693982000287 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 693982000288 tetracycline repressor protein TetR; Provisional; Region: PRK13756 693982000289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982000290 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 693982000291 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693982000292 homotrimer interaction site [polypeptide binding]; other site 693982000293 putative active site [active] 693982000294 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 693982000295 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 693982000296 phosphate binding site [ion binding]; other site 693982000297 Domain of unknown function DUF11; Region: DUF11; cl17728 693982000298 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 693982000299 Domain of unknown function DUF11; Region: DUF11; pfam01345 693982000300 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 693982000301 Domain of unknown function DUF11; Region: DUF11; pfam01345 693982000302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 693982000303 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 693982000304 trimer interface [polypeptide binding]; other site 693982000305 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 693982000306 trimer interface [polypeptide binding]; other site 693982000307 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 693982000308 trimer interface [polypeptide binding]; other site 693982000309 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 693982000310 trimer interface [polypeptide binding]; other site 693982000311 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 693982000312 Haemagglutinin; Region: HIM; pfam05662 693982000313 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 693982000314 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 693982000315 putative deacylase active site [active] 693982000316 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 693982000317 Uncharacterized conserved protein [Function unknown]; Region: COG5579 693982000318 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982000319 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982000320 active site 693982000321 catalytic tetrad [active] 693982000322 Uncharacterized conserved protein [Function unknown]; Region: COG1739 693982000323 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 693982000324 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 693982000325 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 693982000326 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 693982000327 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 693982000328 Glutamate binding site [chemical binding]; other site 693982000329 NAD binding site [chemical binding]; other site 693982000330 catalytic residues [active] 693982000331 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693982000332 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 693982000333 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 693982000334 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693982000335 active site 693982000336 metal binding site [ion binding]; metal-binding site 693982000337 hexamer interface [polypeptide binding]; other site 693982000338 FecR protein; Region: FecR; pfam04773 693982000339 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 693982000340 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 693982000341 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982000342 cyclase homology domain; Region: CHD; cd07302 693982000343 nucleotidyl binding site; other site 693982000344 metal binding site [ion binding]; metal-binding site 693982000345 dimer interface [polypeptide binding]; other site 693982000346 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693982000347 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693982000348 ligand binding site [chemical binding]; other site 693982000349 flexible hinge region; other site 693982000350 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 693982000351 putative switch regulator; other site 693982000352 non-specific DNA interactions [nucleotide binding]; other site 693982000353 DNA binding site [nucleotide binding] 693982000354 sequence specific DNA binding site [nucleotide binding]; other site 693982000355 putative cAMP binding site [chemical binding]; other site 693982000356 Predicted membrane protein [Function unknown]; Region: COG2259 693982000357 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 693982000358 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693982000359 non-specific DNA interactions [nucleotide binding]; other site 693982000360 DNA binding site [nucleotide binding] 693982000361 sequence specific DNA binding site [nucleotide binding]; other site 693982000362 putative cAMP binding site [chemical binding]; other site 693982000363 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693982000364 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693982000365 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982000366 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 693982000367 ligand binding site [chemical binding]; other site 693982000368 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982000369 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982000370 TM-ABC transporter signature motif; other site 693982000371 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 693982000372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982000373 Walker A/P-loop; other site 693982000374 ATP binding site [chemical binding]; other site 693982000375 Q-loop/lid; other site 693982000376 ABC transporter signature motif; other site 693982000377 Walker B; other site 693982000378 D-loop; other site 693982000379 H-loop/switch region; other site 693982000380 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 693982000381 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 693982000382 active site 693982000383 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 693982000384 active site 693982000385 substrate binding pocket [chemical binding]; other site 693982000386 dimer interface [polypeptide binding]; other site 693982000387 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693982000388 active site 693982000389 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693982000390 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 693982000391 putative substrate binding site [chemical binding]; other site 693982000392 putative ATP binding site [chemical binding]; other site 693982000393 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 693982000394 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 693982000395 active site 693982000396 dimer interface [polypeptide binding]; other site 693982000397 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 693982000398 dimer interface [polypeptide binding]; other site 693982000399 active site 693982000400 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 693982000401 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 693982000402 acyl-activating enzyme (AAE) consensus motif; other site 693982000403 putative AMP binding site [chemical binding]; other site 693982000404 putative active site [active] 693982000405 putative CoA binding site [chemical binding]; other site 693982000406 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693982000407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982000408 putative substrate translocation pore; other site 693982000409 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693982000410 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 693982000411 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693982000412 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693982000413 putative acyl-acceptor binding pocket; other site 693982000414 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 693982000415 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 693982000416 integrase; Provisional; Region: PRK09692 693982000417 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 693982000418 active site 693982000419 Int/Topo IB signature motif; other site 693982000420 transposase; Validated; Region: PRK08181 693982000421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982000422 Walker A motif; other site 693982000423 ATP binding site [chemical binding]; other site 693982000424 Walker B motif; other site 693982000425 Integrase core domain; Region: rve; pfam00665 693982000426 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 693982000427 inner capsid protein lambda-1 or VP3; Region: lambda-1; cd11674 693982000428 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982000429 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982000430 non-specific DNA binding site [nucleotide binding]; other site 693982000431 salt bridge; other site 693982000432 sequence-specific DNA binding site [nucleotide binding]; other site 693982000433 HNH endonuclease; Region: HNH_2; pfam13391 693982000434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982000435 AAA domain; Region: AAA_23; pfam13476 693982000436 Walker A/P-loop; other site 693982000437 ATP binding site [chemical binding]; other site 693982000438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982000439 Walker B; other site 693982000440 D-loop; other site 693982000441 H-loop/switch region; other site 693982000442 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 693982000443 DNA protecting protein DprA; Region: dprA; TIGR00732 693982000444 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693982000445 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693982000446 ATP binding site [chemical binding]; other site 693982000447 putative Mg++ binding site [ion binding]; other site 693982000448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693982000449 nucleotide binding region [chemical binding]; other site 693982000450 ATP-binding site [chemical binding]; other site 693982000451 Catalytic GIY-YIG domain of coliphage T4 non-specific endonuclease II, type II restriction endonuclease R.Hpy188I, and similar proteins; Region: GIY-YIG_EndoII_Hpy188I_like; cd10436 693982000452 GIY-YIG motif/motif A; other site 693982000453 DNA binding site [nucleotide binding] 693982000454 active site 693982000455 catalytic site [active] 693982000456 metal binding site [ion binding]; metal-binding site 693982000457 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 693982000458 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 693982000459 FMN binding site [chemical binding]; other site 693982000460 substrate binding site [chemical binding]; other site 693982000461 putative catalytic residue [active] 693982000462 Uncharacterized conserved protein [Function unknown]; Region: COG2326 693982000463 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 693982000464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982000465 dimer interface [polypeptide binding]; other site 693982000466 phosphorylation site [posttranslational modification] 693982000467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982000468 ATP binding site [chemical binding]; other site 693982000469 Mg2+ binding site [ion binding]; other site 693982000470 G-X-G motif; other site 693982000471 PBP superfamily domain; Region: PBP_like_2; pfam12849 693982000472 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 693982000473 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 693982000474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982000475 dimer interface [polypeptide binding]; other site 693982000476 conserved gate region; other site 693982000477 putative PBP binding loops; other site 693982000478 ABC-ATPase subunit interface; other site 693982000479 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 693982000480 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 693982000481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982000482 dimer interface [polypeptide binding]; other site 693982000483 conserved gate region; other site 693982000484 putative PBP binding loops; other site 693982000485 ABC-ATPase subunit interface; other site 693982000486 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 693982000487 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 693982000488 Walker A/P-loop; other site 693982000489 ATP binding site [chemical binding]; other site 693982000490 Q-loop/lid; other site 693982000491 ABC transporter signature motif; other site 693982000492 Walker B; other site 693982000493 D-loop; other site 693982000494 H-loop/switch region; other site 693982000495 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 693982000496 PhoU domain; Region: PhoU; pfam01895 693982000497 PhoU domain; Region: PhoU; pfam01895 693982000498 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 693982000499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982000500 active site 693982000501 phosphorylation site [posttranslational modification] 693982000502 intermolecular recognition site; other site 693982000503 dimerization interface [polypeptide binding]; other site 693982000504 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982000505 DNA binding site [nucleotide binding] 693982000506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 693982000507 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 693982000508 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693982000509 inhibitor-cofactor binding pocket; inhibition site 693982000510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982000511 catalytic residue [active] 693982000512 ornithine carbamoyltransferase; Provisional; Region: PRK00779 693982000513 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693982000514 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693982000515 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 693982000516 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 693982000517 dimerization interface [polypeptide binding]; other site 693982000518 domain crossover interface; other site 693982000519 redox-dependent activation switch; other site 693982000520 Uncharacterized protein affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism]; Region: ApaG; COG2967 693982000521 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 693982000522 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 693982000523 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693982000524 homodimer interface [polypeptide binding]; other site 693982000525 substrate-cofactor binding pocket; other site 693982000526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982000527 catalytic residue [active] 693982000528 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 693982000529 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 693982000530 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 693982000531 trimer interface [polypeptide binding]; other site 693982000532 active site 693982000533 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 693982000534 trimer interface [polypeptide binding]; other site 693982000535 active site 693982000536 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693982000537 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982000538 substrate binding pocket [chemical binding]; other site 693982000539 membrane-bound complex binding site; other site 693982000540 hinge residues; other site 693982000541 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 693982000542 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 693982000543 tellurite resistance protein terB; Region: terB; cd07176 693982000544 putative metal binding site [ion binding]; other site 693982000545 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 693982000546 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 693982000547 Predicted transcriptional regulator [Transcription]; Region: COG2932 693982000548 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693982000549 Catalytic site [active] 693982000550 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 693982000551 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693982000552 Predicted transcriptional regulators [Transcription]; Region: COG1733 693982000553 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 693982000554 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 693982000555 putative hydrophobic ligand binding site [chemical binding]; other site 693982000556 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 693982000557 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693982000558 substrate binding site [chemical binding]; other site 693982000559 oxyanion hole (OAH) forming residues; other site 693982000560 trimer interface [polypeptide binding]; other site 693982000561 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693982000562 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693982000563 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693982000564 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 693982000565 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693982000566 dimer interface [polypeptide binding]; other site 693982000567 active site 693982000568 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 693982000569 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 693982000570 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 693982000571 FAD binding site [chemical binding]; other site 693982000572 substrate binding site [chemical binding]; other site 693982000573 catalytic residues [active] 693982000574 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 693982000575 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693982000576 Sel1 repeat; Region: Sel1; pfam08238 693982000577 Sel1-like repeats; Region: SEL1; smart00671 693982000578 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 693982000579 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982000580 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693982000581 conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186 693982000582 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982000583 AsnC family; Region: AsnC_trans_reg; pfam01037 693982000584 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693982000585 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 693982000586 putative active site [active] 693982000587 putative metal binding site [ion binding]; other site 693982000588 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 693982000589 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693982000590 ATP binding site [chemical binding]; other site 693982000591 putative Mg++ binding site [ion binding]; other site 693982000592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693982000593 nucleotide binding region [chemical binding]; other site 693982000594 ATP-binding site [chemical binding]; other site 693982000595 DEAD/H associated; Region: DEAD_assoc; pfam08494 693982000596 Predicted transcriptional regulator [Transcription]; Region: COG1959 693982000597 Transcriptional regulator; Region: Rrf2; pfam02082 693982000598 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 693982000599 Uncharacterized conserved protein [Function unknown]; Region: COG2128 693982000600 Uncharacterized conserved protein [Function unknown]; Region: COG1284 693982000601 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 693982000602 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 693982000603 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 693982000604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982000605 S-adenosylmethionine binding site [chemical binding]; other site 693982000606 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 693982000607 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 693982000608 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693982000609 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 693982000610 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 693982000611 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 693982000612 quinone interaction residues [chemical binding]; other site 693982000613 active site 693982000614 catalytic residues [active] 693982000615 FMN binding site [chemical binding]; other site 693982000616 substrate binding site [chemical binding]; other site 693982000617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 693982000618 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982000619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982000620 active site 693982000621 phosphorylation site [posttranslational modification] 693982000622 intermolecular recognition site; other site 693982000623 dimerization interface [polypeptide binding]; other site 693982000624 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982000625 DNA binding residues [nucleotide binding] 693982000626 dimerization interface [polypeptide binding]; other site 693982000627 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 693982000628 Na binding site [ion binding]; other site 693982000629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982000630 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982000631 dimer interface [polypeptide binding]; other site 693982000632 phosphorylation site [posttranslational modification] 693982000633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982000634 ATP binding site [chemical binding]; other site 693982000635 Mg2+ binding site [ion binding]; other site 693982000636 G-X-G motif; other site 693982000637 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693982000638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982000639 active site 693982000640 phosphorylation site [posttranslational modification] 693982000641 intermolecular recognition site; other site 693982000642 dimerization interface [polypeptide binding]; other site 693982000643 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 693982000644 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 693982000645 aspartate aminotransferase; Provisional; Region: PRK06108 693982000646 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982000647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982000648 homodimer interface [polypeptide binding]; other site 693982000649 catalytic residue [active] 693982000650 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 693982000651 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 693982000652 NAD binding site [chemical binding]; other site 693982000653 homodimer interface [polypeptide binding]; other site 693982000654 active site 693982000655 substrate binding site [chemical binding]; other site 693982000656 chorismate mutase related enzymes; Region: CM-like; TIGR01803 693982000657 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 693982000658 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 693982000659 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 693982000660 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693982000661 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 693982000662 metal binding site [ion binding]; metal-binding site 693982000663 putative dimer interface [polypeptide binding]; other site 693982000664 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693982000665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982000666 dimer interface [polypeptide binding]; other site 693982000667 conserved gate region; other site 693982000668 putative PBP binding loops; other site 693982000669 ABC-ATPase subunit interface; other site 693982000670 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693982000671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982000672 dimer interface [polypeptide binding]; other site 693982000673 conserved gate region; other site 693982000674 putative PBP binding loops; other site 693982000675 ABC-ATPase subunit interface; other site 693982000676 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982000677 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693982000678 substrate binding pocket [chemical binding]; other site 693982000679 membrane-bound complex binding site; other site 693982000680 hinge residues; other site 693982000681 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 693982000682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982000683 Walker A/P-loop; other site 693982000684 ATP binding site [chemical binding]; other site 693982000685 Q-loop/lid; other site 693982000686 ABC transporter signature motif; other site 693982000687 Walker B; other site 693982000688 D-loop; other site 693982000689 H-loop/switch region; other site 693982000690 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 693982000691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982000692 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 693982000693 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 693982000694 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982000695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982000696 homodimer interface [polypeptide binding]; other site 693982000697 catalytic residue [active] 693982000698 hypothetical protein; Provisional; Region: PRK07524 693982000699 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693982000700 PYR/PP interface [polypeptide binding]; other site 693982000701 dimer interface [polypeptide binding]; other site 693982000702 TPP binding site [chemical binding]; other site 693982000703 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693982000704 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 693982000705 TPP-binding site [chemical binding]; other site 693982000706 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 693982000707 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 693982000708 Protein export membrane protein; Region: SecD_SecF; pfam02355 693982000709 Rrf2 family protein; Region: rrf2_super; TIGR00738 693982000710 Transcriptional regulator; Region: Rrf2; pfam02082 693982000711 KpsF/GutQ family protein; Region: kpsF; TIGR00393 693982000712 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 693982000713 putative active site [active] 693982000714 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 693982000715 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 693982000716 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 693982000717 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 693982000718 Sulfatase; Region: Sulfatase; cl17466 693982000719 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 693982000720 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 693982000721 putative NAD(P) binding site [chemical binding]; other site 693982000722 homotetramer interface [polypeptide binding]; other site 693982000723 active site 693982000724 homodimer interface [polypeptide binding]; other site 693982000725 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 693982000726 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693982000727 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693982000728 catalytic residue [active] 693982000729 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 693982000730 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 693982000731 active site 693982000732 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 693982000733 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 693982000734 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 693982000735 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 693982000736 Enoylreductase; Region: PKS_ER; smart00829 693982000737 NAD(P) binding site [chemical binding]; other site 693982000738 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 693982000739 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 693982000740 putative NADP binding site [chemical binding]; other site 693982000741 active site 693982000742 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 693982000743 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 693982000744 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 693982000745 SLBB domain; Region: SLBB; pfam10531 693982000746 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 693982000747 Isochorismatase family; Region: Isochorismatase; pfam00857 693982000748 catalytic triad [active] 693982000749 metal binding site [ion binding]; metal-binding site 693982000750 conserved cis-peptide bond; other site 693982000751 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 693982000752 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 693982000753 active site 693982000754 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 693982000755 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 693982000756 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 693982000757 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 693982000758 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 693982000759 Uncharacterized conserved protein [Function unknown]; Region: COG5569 693982000760 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982000761 cyclase homology domain; Region: CHD; cd07302 693982000762 nucleotidyl binding site; other site 693982000763 metal binding site [ion binding]; metal-binding site 693982000764 dimer interface [polypeptide binding]; other site 693982000765 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693982000766 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693982000767 active site 693982000768 catalytic residues [active] 693982000769 DNA binding site [nucleotide binding] 693982000770 Int/Topo IB signature motif; other site 693982000771 HNH endonuclease; Region: HNH_3; pfam13392 693982000772 DNA polymerase III subunit beta; Validated; Region: PRK05643 693982000773 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 693982000774 putative DNA binding surface [nucleotide binding]; other site 693982000775 dimer interface [polypeptide binding]; other site 693982000776 beta-clamp/clamp loader binding surface; other site 693982000777 beta-clamp/translesion DNA polymerase binding surface; other site 693982000778 hypothetical protein; Provisional; Region: PRK13694 693982000779 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693982000780 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693982000781 dimer interface [polypeptide binding]; other site 693982000782 ssDNA binding site [nucleotide binding]; other site 693982000783 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693982000784 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982000785 non-specific DNA binding site [nucleotide binding]; other site 693982000786 salt bridge; other site 693982000787 sequence-specific DNA binding site [nucleotide binding]; other site 693982000788 Predicted transcriptional regulator [Transcription]; Region: COG2932 693982000789 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693982000790 Catalytic site [active] 693982000791 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 693982000792 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; pfam08273 693982000793 D5 N terminal like; Region: D5_N; smart00885 693982000794 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 693982000795 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615 693982000796 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 693982000797 gpW; Region: gpW; pfam02831 693982000798 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 693982000799 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 693982000800 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 693982000801 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 693982000802 tandem repeat interface [polypeptide binding]; other site 693982000803 oligomer interface [polypeptide binding]; other site 693982000804 active site residues [active] 693982000805 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 693982000806 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 693982000807 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 693982000808 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 693982000809 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 693982000810 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 693982000811 autotransport protein MisL; Provisional; Region: PRK15313 693982000812 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693982000813 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693982000814 catalytic residues [active] 693982000815 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 693982000816 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693982000817 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693982000818 catalytic residues [active] 693982000819 RES domain; Region: RES; smart00953 693982000820 AAA domain; Region: AAA_17; pfam13207 693982000821 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 693982000822 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 693982000823 hinge; other site 693982000824 active site 693982000825 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 693982000826 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 693982000827 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 693982000828 NAD binding site [chemical binding]; other site 693982000829 dimerization interface [polypeptide binding]; other site 693982000830 product binding site; other site 693982000831 substrate binding site [chemical binding]; other site 693982000832 zinc binding site [ion binding]; other site 693982000833 catalytic residues [active] 693982000834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5328 693982000835 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 693982000836 Low molecular weight phosphatase family; Region: LMWPc; cd00115 693982000837 active site 693982000838 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 693982000839 rRNA binding site [nucleotide binding]; other site 693982000840 predicted 30S ribosome binding site; other site 693982000841 Maf-like protein; Region: Maf; pfam02545 693982000842 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 693982000843 active site 693982000844 dimer interface [polypeptide binding]; other site 693982000845 zinc-binding protein; Provisional; Region: PRK01343 693982000846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 693982000847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 693982000848 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 693982000849 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 693982000850 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 693982000851 active site 693982000852 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 693982000853 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 693982000854 putative deacylase active site [active] 693982000855 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952 693982000856 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 693982000857 short chain dehydrogenase; Validated; Region: PRK08324 693982000858 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 693982000859 active site 693982000860 Zn2+ binding site [ion binding]; other site 693982000861 intersubunit interface [polypeptide binding]; other site 693982000862 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 693982000863 putative NAD(P) binding site [chemical binding]; other site 693982000864 active site 693982000865 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693982000866 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 693982000867 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693982000868 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 693982000869 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 693982000870 ligand binding site [chemical binding]; other site 693982000871 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982000872 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982000873 Walker A/P-loop; other site 693982000874 ATP binding site [chemical binding]; other site 693982000875 Q-loop/lid; other site 693982000876 ABC transporter signature motif; other site 693982000877 Walker B; other site 693982000878 D-loop; other site 693982000879 H-loop/switch region; other site 693982000880 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982000881 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982000882 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982000883 TM-ABC transporter signature motif; other site 693982000884 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982000885 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982000886 TM-ABC transporter signature motif; other site 693982000887 Uncharacterized conserved protein [Function unknown]; Region: COG3254 693982000888 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 693982000889 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 693982000890 N- and C-terminal domain interface [polypeptide binding]; other site 693982000891 putative active site [active] 693982000892 putative MgATP binding site [chemical binding]; other site 693982000893 putative catalytic site [active] 693982000894 metal binding site [ion binding]; metal-binding site 693982000895 putative carbohydrate binding site [chemical binding]; other site 693982000896 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 693982000897 heme-binding site [chemical binding]; other site 693982000898 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693982000899 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693982000900 dimer interface [polypeptide binding]; other site 693982000901 putative CheW interface [polypeptide binding]; other site 693982000902 STAS domain; Region: STAS_2; pfam13466 693982000903 Response regulator receiver domain; Region: Response_reg; pfam00072 693982000904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982000905 active site 693982000906 phosphorylation site [posttranslational modification] 693982000907 intermolecular recognition site; other site 693982000908 dimerization interface [polypeptide binding]; other site 693982000909 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 693982000910 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693982000911 putative binding surface; other site 693982000912 active site 693982000913 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 693982000914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982000915 ATP binding site [chemical binding]; other site 693982000916 Mg2+ binding site [ion binding]; other site 693982000917 G-X-G motif; other site 693982000918 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 693982000919 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 693982000920 putative CheA interaction surface; other site 693982000921 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 693982000922 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 693982000923 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 693982000924 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 693982000925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982000926 active site 693982000927 phosphorylation site [posttranslational modification] 693982000928 intermolecular recognition site; other site 693982000929 dimerization interface [polypeptide binding]; other site 693982000930 CheB methylesterase; Region: CheB_methylest; pfam01339 693982000931 Response regulator receiver domain; Region: Response_reg; pfam00072 693982000932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982000933 active site 693982000934 phosphorylation site [posttranslational modification] 693982000935 intermolecular recognition site; other site 693982000936 dimerization interface [polypeptide binding]; other site 693982000937 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13497 693982000938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693982000939 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693982000940 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693982000941 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 693982000942 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 693982000943 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 693982000944 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982000945 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982000946 dimerization interface [polypeptide binding]; other site 693982000947 DNA binding residues [nucleotide binding] 693982000948 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982000949 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982000950 DNA binding residues [nucleotide binding] 693982000951 dimerization interface [polypeptide binding]; other site 693982000952 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 693982000953 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 693982000954 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 693982000955 FliG C-terminal domain; Region: FliG_C; pfam01706 693982000956 flagellar motor switch protein FliN; Region: fliN; TIGR02480 693982000957 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 693982000958 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 693982000959 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 693982000960 flagellar motor protein MotA; Validated; Region: PRK09110 693982000961 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 693982000962 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 693982000963 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 693982000964 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693982000965 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 693982000966 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 693982000967 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693982000968 Walker A motif; other site 693982000969 ATP binding site [chemical binding]; other site 693982000970 Walker B motif; other site 693982000971 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 693982000972 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 693982000973 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693982000974 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693982000975 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 693982000976 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 693982000977 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693982000978 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 693982000979 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 693982000980 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 693982000981 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 693982000982 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 693982000983 Uncharacterized conserved protein [Function unknown]; Region: COG3334 693982000984 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 693982000985 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 693982000986 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 693982000987 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 693982000988 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 693982000989 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693982000990 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693982000991 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 693982000992 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693982000993 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693982000994 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 693982000995 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693982000996 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693982000997 flagellin; Reviewed; Region: PRK12687 693982000998 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693982000999 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693982001000 Kinesin-related; Region: Kinesin-related; pfam06548 693982001001 flagellar motor protein MotB; Validated; Region: motB; PRK05996 693982001002 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 693982001003 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693982001004 ligand binding site [chemical binding]; other site 693982001005 chemotaxis protein; Reviewed; Region: PRK12798 693982001006 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 693982001007 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 693982001008 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693982001009 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693982001010 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982001011 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982001012 DNA binding site [nucleotide binding] 693982001013 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 693982001014 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693982001015 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 693982001016 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693982001017 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 693982001018 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 693982001019 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693982001020 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693982001021 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 693982001022 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 693982001023 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 693982001024 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 693982001025 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 693982001026 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 693982001027 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 693982001028 FHIPEP family; Region: FHIPEP; pfam00771 693982001029 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 693982001030 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 693982001031 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693982001032 active site 693982001033 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 693982001034 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 693982001035 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 693982001036 homodimer interface [polypeptide binding]; other site 693982001037 NADP binding site [chemical binding]; other site 693982001038 substrate binding site [chemical binding]; other site 693982001039 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982001040 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982001041 DNA binding site [nucleotide binding] 693982001042 domain linker motif; other site 693982001043 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 693982001044 ligand binding site [chemical binding]; other site 693982001045 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982001046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982001047 dimer interface [polypeptide binding]; other site 693982001048 conserved gate region; other site 693982001049 putative PBP binding loops; other site 693982001050 ABC-ATPase subunit interface; other site 693982001051 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982001052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982001053 dimer interface [polypeptide binding]; other site 693982001054 conserved gate region; other site 693982001055 putative PBP binding loops; other site 693982001056 ABC-ATPase subunit interface; other site 693982001057 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 693982001058 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 693982001059 active site 693982001060 catalytic site [active] 693982001061 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982001062 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982001063 Walker A/P-loop; other site 693982001064 ATP binding site [chemical binding]; other site 693982001065 Q-loop/lid; other site 693982001066 ABC transporter signature motif; other site 693982001067 Walker B; other site 693982001068 D-loop; other site 693982001069 H-loop/switch region; other site 693982001070 TOBE domain; Region: TOBE_2; pfam08402 693982001071 6-phosphogluconate dehydratase; Region: edd; TIGR01196 693982001072 phosphogluconate dehydratase; Validated; Region: PRK09054 693982001073 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 693982001074 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 693982001075 putative active site [active] 693982001076 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 693982001077 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 693982001078 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 693982001079 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693982001080 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982001081 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 693982001082 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 693982001083 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693982001084 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693982001085 dimerization interface [polypeptide binding]; other site 693982001086 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693982001087 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693982001088 dimer interface [polypeptide binding]; other site 693982001089 putative CheW interface [polypeptide binding]; other site 693982001090 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982001091 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982001092 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693982001093 Sel1-like repeats; Region: SEL1; smart00671 693982001094 Sel1 repeat; Region: Sel1; cl02723 693982001095 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 693982001096 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 693982001097 putative active site [active] 693982001098 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693982001099 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693982001100 catalytic residues [active] 693982001101 catalytic nucleophile [active] 693982001102 Presynaptic Site I dimer interface [polypeptide binding]; other site 693982001103 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693982001104 Synaptic Flat tetramer interface [polypeptide binding]; other site 693982001105 Synaptic Site I dimer interface [polypeptide binding]; other site 693982001106 DNA binding site [nucleotide binding] 693982001107 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 693982001108 DNA-binding interface [nucleotide binding]; DNA binding site 693982001109 isocitrate lyase; Provisional; Region: PRK15063 693982001110 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693982001111 tetramer interface [polypeptide binding]; other site 693982001112 active site 693982001113 Mg2+/Mn2+ binding site [ion binding]; other site 693982001114 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982001115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982001116 non-specific DNA binding site [nucleotide binding]; other site 693982001117 salt bridge; other site 693982001118 sequence-specific DNA binding site [nucleotide binding]; other site 693982001119 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 693982001120 Domain of unknown function (DUF955); Region: DUF955; pfam06114 693982001121 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 693982001122 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 693982001123 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693982001124 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693982001125 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 693982001126 Walker A/P-loop; other site 693982001127 ATP binding site [chemical binding]; other site 693982001128 Q-loop/lid; other site 693982001129 ABC transporter signature motif; other site 693982001130 Walker B; other site 693982001131 D-loop; other site 693982001132 H-loop/switch region; other site 693982001133 TOBE domain; Region: TOBE_2; pfam08402 693982001134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982001135 dimer interface [polypeptide binding]; other site 693982001136 conserved gate region; other site 693982001137 putative PBP binding loops; other site 693982001138 ABC-ATPase subunit interface; other site 693982001139 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982001140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982001141 dimer interface [polypeptide binding]; other site 693982001142 conserved gate region; other site 693982001143 putative PBP binding loops; other site 693982001144 ABC-ATPase subunit interface; other site 693982001145 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 693982001146 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693982001147 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 693982001148 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 693982001149 acyl-activating enzyme (AAE) consensus motif; other site 693982001150 putative AMP binding site [chemical binding]; other site 693982001151 putative active site [active] 693982001152 putative CoA binding site [chemical binding]; other site 693982001153 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 693982001154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982001155 dimer interface [polypeptide binding]; other site 693982001156 conserved gate region; other site 693982001157 putative PBP binding loops; other site 693982001158 ABC-ATPase subunit interface; other site 693982001159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982001160 dimer interface [polypeptide binding]; other site 693982001161 conserved gate region; other site 693982001162 putative PBP binding loops; other site 693982001163 ABC-ATPase subunit interface; other site 693982001164 PAS domain S-box; Region: sensory_box; TIGR00229 693982001165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982001166 putative active site [active] 693982001167 heme pocket [chemical binding]; other site 693982001168 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982001169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982001170 dimer interface [polypeptide binding]; other site 693982001171 phosphorylation site [posttranslational modification] 693982001172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982001173 ATP binding site [chemical binding]; other site 693982001174 Mg2+ binding site [ion binding]; other site 693982001175 G-X-G motif; other site 693982001176 Uncharacterized conserved protein [Function unknown]; Region: COG5490 693982001177 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 693982001178 classical (c) SDRs; Region: SDR_c; cd05233 693982001179 NAD(P) binding site [chemical binding]; other site 693982001180 active site 693982001181 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 693982001182 FAD binding domain; Region: FAD_binding_4; pfam01565 693982001183 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 693982001184 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982001185 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982001186 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982001187 dimerization interface [polypeptide binding]; other site 693982001188 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 693982001189 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 693982001190 tetrameric interface [polypeptide binding]; other site 693982001191 NAD binding site [chemical binding]; other site 693982001192 catalytic residues [active] 693982001193 Predicted membrane protein [Function unknown]; Region: COG4269 693982001194 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 693982001195 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 693982001196 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 693982001197 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 693982001198 Rrf2 family protein; Region: rrf2_super; TIGR00738 693982001199 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982001200 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 693982001201 peptide binding site [polypeptide binding]; other site 693982001202 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982001203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982001204 dimer interface [polypeptide binding]; other site 693982001205 conserved gate region; other site 693982001206 putative PBP binding loops; other site 693982001207 ABC-ATPase subunit interface; other site 693982001208 dipeptide transporter; Provisional; Region: PRK10913 693982001209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982001210 dimer interface [polypeptide binding]; other site 693982001211 conserved gate region; other site 693982001212 putative PBP binding loops; other site 693982001213 ABC-ATPase subunit interface; other site 693982001214 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982001215 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 693982001216 Walker A/P-loop; other site 693982001217 ATP binding site [chemical binding]; other site 693982001218 Q-loop/lid; other site 693982001219 ABC transporter signature motif; other site 693982001220 Walker B; other site 693982001221 D-loop; other site 693982001222 H-loop/switch region; other site 693982001223 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982001224 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982001225 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 693982001226 Walker A/P-loop; other site 693982001227 ATP binding site [chemical binding]; other site 693982001228 Q-loop/lid; other site 693982001229 ABC transporter signature motif; other site 693982001230 Walker B; other site 693982001231 D-loop; other site 693982001232 H-loop/switch region; other site 693982001233 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982001234 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 693982001235 homotrimer interaction site [polypeptide binding]; other site 693982001236 putative active site [active] 693982001237 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693982001238 two-component response regulator; Provisional; Region: PRK09191 693982001239 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 693982001240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982001241 active site 693982001242 phosphorylation site [posttranslational modification] 693982001243 intermolecular recognition site; other site 693982001244 dimerization interface [polypeptide binding]; other site 693982001245 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982001246 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693982001247 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693982001248 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 693982001249 MgtC family; Region: MgtC; pfam02308 693982001250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 693982001251 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 693982001252 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 693982001253 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 693982001254 Chromate transporter; Region: Chromate_transp; pfam02417 693982001255 exopolyphosphatase; Region: exo_poly_only; TIGR03706 693982001256 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 693982001257 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 693982001258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982001259 S-adenosylmethionine binding site [chemical binding]; other site 693982001260 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 693982001261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982001262 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693982001263 putative substrate translocation pore; other site 693982001264 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693982001265 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 693982001266 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 693982001267 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 693982001268 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 693982001269 active site 693982001270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5331 693982001271 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 693982001272 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 693982001273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982001274 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 693982001275 dimerization interface [polypeptide binding]; other site 693982001276 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 693982001277 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 693982001278 tetramer interface [polypeptide binding]; other site 693982001279 heme binding pocket [chemical binding]; other site 693982001280 NADPH binding site [chemical binding]; other site 693982001281 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 693982001282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982001283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982001284 dimerization interface [polypeptide binding]; other site 693982001285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 693982001286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982001287 non-specific DNA binding site [nucleotide binding]; other site 693982001288 salt bridge; other site 693982001289 sequence-specific DNA binding site [nucleotide binding]; other site 693982001290 Uncharacterized conserved protein [Function unknown]; Region: COG5403 693982001291 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 693982001292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 693982001293 RNA methyltransferase, RsmE family; Region: TIGR00046 693982001294 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693982001295 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693982001296 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 693982001297 nudix motif; other site 693982001298 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982001299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982001300 DNA-binding site [nucleotide binding]; DNA binding site 693982001301 FCD domain; Region: FCD; pfam07729 693982001302 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4949 693982001303 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982001304 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982001305 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693982001306 putative effector binding pocket; other site 693982001307 dimerization interface [polypeptide binding]; other site 693982001308 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 693982001309 FAD binding domain; Region: FAD_binding_4; pfam01565 693982001310 FAD binding domain; Region: FAD_binding_4; pfam01565 693982001311 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 693982001312 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 693982001313 Cysteine-rich domain; Region: CCG; pfam02754 693982001314 Cysteine-rich domain; Region: CCG; pfam02754 693982001315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 693982001316 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982001317 Homeodomain-like domain; Region: HTH_32; pfam13565 693982001318 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693982001319 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693982001320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 693982001321 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693982001322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 693982001323 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693982001324 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 693982001325 Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953 693982001326 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 693982001327 Na binding site [ion binding]; other site 693982001328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 693982001329 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 693982001330 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 693982001331 dimer interface [polypeptide binding]; other site 693982001332 motif 1; other site 693982001333 active site 693982001334 motif 2; other site 693982001335 motif 3; other site 693982001336 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 693982001337 anticodon binding site; other site 693982001338 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 693982001339 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693982001340 motif 1; other site 693982001341 dimer interface [polypeptide binding]; other site 693982001342 active site 693982001343 motif 2; other site 693982001344 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693982001345 motif 3; other site 693982001346 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 693982001347 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 693982001348 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982001349 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 693982001350 C-terminal domain interface [polypeptide binding]; other site 693982001351 GSH binding site (G-site) [chemical binding]; other site 693982001352 dimer interface [polypeptide binding]; other site 693982001353 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 693982001354 dimer interface [polypeptide binding]; other site 693982001355 N-terminal domain interface [polypeptide binding]; other site 693982001356 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 693982001357 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693982001358 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982001359 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 693982001360 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 693982001361 ring oligomerisation interface [polypeptide binding]; other site 693982001362 ATP/Mg binding site [chemical binding]; other site 693982001363 stacking interactions; other site 693982001364 hinge regions; other site 693982001365 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 693982001366 oligomerisation interface [polypeptide binding]; other site 693982001367 mobile loop; other site 693982001368 roof hairpin; other site 693982001369 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 693982001370 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 693982001371 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 693982001372 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 693982001373 active site 693982001374 Riboflavin kinase; Region: Flavokinase; smart00904 693982001375 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 693982001376 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693982001377 active site 693982001378 HIGH motif; other site 693982001379 nucleotide binding site [chemical binding]; other site 693982001380 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 693982001381 active site 693982001382 KMSKS motif; other site 693982001383 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 693982001384 tRNA binding surface [nucleotide binding]; other site 693982001385 anticodon binding site; other site 693982001386 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 693982001387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982001388 Coenzyme A binding pocket [chemical binding]; other site 693982001389 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 693982001390 nucleoside/Zn binding site; other site 693982001391 dimer interface [polypeptide binding]; other site 693982001392 catalytic motif [active] 693982001393 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 693982001394 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693982001395 RNA binding surface [nucleotide binding]; other site 693982001396 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 693982001397 active site 693982001398 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 693982001399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982001400 S-adenosylmethionine binding site [chemical binding]; other site 693982001401 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 693982001402 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 693982001403 nucleophile elbow; other site 693982001404 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 693982001405 putative active site [active] 693982001406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 693982001407 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 693982001408 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 693982001409 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 693982001410 TrkA-N domain; Region: TrkA_N; pfam02254 693982001411 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 693982001412 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693982001413 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 693982001414 active site 693982001415 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 693982001416 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 693982001417 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 693982001418 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693982001419 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 693982001420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982001421 motif II; other site 693982001422 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 693982001423 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 693982001424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 693982001425 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 693982001426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982001427 ATP binding site [chemical binding]; other site 693982001428 Mg2+ binding site [ion binding]; other site 693982001429 G-X-G motif; other site 693982001430 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 693982001431 ATP binding site [chemical binding]; other site 693982001432 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 693982001433 PAS fold; Region: PAS_4; pfam08448 693982001434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982001435 putative active site [active] 693982001436 heme pocket [chemical binding]; other site 693982001437 Response regulator receiver domain; Region: Response_reg; pfam00072 693982001438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982001439 active site 693982001440 phosphorylation site [posttranslational modification] 693982001441 intermolecular recognition site; other site 693982001442 dimerization interface [polypeptide binding]; other site 693982001443 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982001444 metal binding site [ion binding]; metal-binding site 693982001445 active site 693982001446 I-site; other site 693982001447 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693982001448 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693982001449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982001450 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693982001451 dimerization interface [polypeptide binding]; other site 693982001452 substrate binding pocket [chemical binding]; other site 693982001453 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 693982001454 PRC-barrel domain; Region: PRC; pfam05239 693982001455 dihydroxy-acid dehydratase; Validated; Region: PRK06131 693982001456 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 693982001457 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 693982001458 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 693982001459 active site 693982001460 intersubunit interface [polypeptide binding]; other site 693982001461 catalytic residue [active] 693982001462 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 693982001463 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 693982001464 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693982001465 classical (c) SDRs; Region: SDR_c; cd05233 693982001466 NAD(P) binding site [chemical binding]; other site 693982001467 active site 693982001468 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693982001469 Bacterial transcriptional regulator; Region: IclR; pfam01614 693982001470 transcriptional regulator TraR; Provisional; Region: PRK13870 693982001471 Autoinducer binding domain; Region: Autoind_bind; pfam03472 693982001472 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982001473 DNA binding residues [nucleotide binding] 693982001474 dimerization interface [polypeptide binding]; other site 693982001475 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 693982001476 Autoinducer binding domain; Region: Autoind_bind; pfam03472 693982001477 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982001478 DNA binding residues [nucleotide binding] 693982001479 dimerization interface [polypeptide binding]; other site 693982001480 Domain of unknown function DUF59; Region: DUF59; pfam01883 693982001481 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 693982001482 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 693982001483 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 693982001484 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 693982001485 Cl binding site [ion binding]; other site 693982001486 oligomer interface [polypeptide binding]; other site 693982001487 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 693982001488 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 693982001489 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 693982001490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 693982001491 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 693982001492 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 693982001493 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 693982001494 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 693982001495 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 693982001496 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 693982001497 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 693982001498 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 693982001499 RNA/DNA hybrid binding site [nucleotide binding]; other site 693982001500 active site 693982001501 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 693982001502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693982001503 FeS/SAM binding site; other site 693982001504 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693982001505 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693982001506 active site 693982001507 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 693982001508 MPT binding site; other site 693982001509 trimer interface [polypeptide binding]; other site 693982001510 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 693982001511 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 693982001512 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 693982001513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982001514 TPR motif; other site 693982001515 binding surface 693982001516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982001517 binding surface 693982001518 TPR motif; other site 693982001519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982001520 binding surface 693982001521 TPR motif; other site 693982001522 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 693982001523 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 693982001524 substrate binding pocket [chemical binding]; other site 693982001525 chain length determination region; other site 693982001526 substrate-Mg2+ binding site; other site 693982001527 catalytic residues [active] 693982001528 aspartate-rich region 1; other site 693982001529 active site lid residues [active] 693982001530 aspartate-rich region 2; other site 693982001531 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 693982001532 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 693982001533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982001534 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 693982001535 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 693982001536 tandem repeat interface [polypeptide binding]; other site 693982001537 oligomer interface [polypeptide binding]; other site 693982001538 active site residues [active] 693982001539 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 693982001540 dimer interface [polypeptide binding]; other site 693982001541 motif 1; other site 693982001542 active site 693982001543 motif 2; other site 693982001544 motif 3; other site 693982001545 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 693982001546 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 693982001547 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 693982001548 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 693982001549 Uncharacterized conserved protein [Function unknown]; Region: COG1683 693982001550 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 693982001551 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 693982001552 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 693982001553 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 693982001554 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693982001555 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982001556 metal binding site [ion binding]; metal-binding site 693982001557 active site 693982001558 I-site; other site 693982001559 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693982001560 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 693982001561 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693982001562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982001563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693982001564 putative substrate translocation pore; other site 693982001565 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693982001566 Helix-turn-helix domain; Region: HTH_18; pfam12833 693982001567 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 693982001568 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 693982001569 UbiA prenyltransferase family; Region: UbiA; pfam01040 693982001570 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 693982001571 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 693982001572 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 693982001573 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 693982001574 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 693982001575 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 693982001576 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693982001577 FAD binding domain; Region: FAD_binding_4; pfam01565 693982001578 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 693982001579 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 693982001580 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 693982001581 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 693982001582 [2Fe-2S] cluster binding site [ion binding]; other site 693982001583 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 693982001584 putative alpha subunit interface [polypeptide binding]; other site 693982001585 putative active site [active] 693982001586 putative substrate binding site [chemical binding]; other site 693982001587 Fe binding site [ion binding]; other site 693982001588 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 693982001589 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 693982001590 FAD binding pocket [chemical binding]; other site 693982001591 FAD binding motif [chemical binding]; other site 693982001592 phosphate binding motif [ion binding]; other site 693982001593 beta-alpha-beta structure motif; other site 693982001594 NAD binding pocket [chemical binding]; other site 693982001595 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982001596 catalytic loop [active] 693982001597 iron binding site [ion binding]; other site 693982001598 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 693982001599 active site 693982001600 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 693982001601 BA14K-like protein; Region: BA14K; pfam07886 693982001602 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 693982001603 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 693982001604 Cl binding site [ion binding]; other site 693982001605 oligomer interface [polypeptide binding]; other site 693982001606 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693982001607 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693982001608 active site 693982001609 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 693982001610 enoyl-CoA hydratase; Provisional; Region: PRK06688 693982001611 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693982001612 substrate binding site [chemical binding]; other site 693982001613 oxyanion hole (OAH) forming residues; other site 693982001614 trimer interface [polypeptide binding]; other site 693982001615 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 693982001616 Cache domain; Region: Cache_1; pfam02743 693982001617 HAMP domain; Region: HAMP; pfam00672 693982001618 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693982001619 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693982001620 dimer interface [polypeptide binding]; other site 693982001621 putative CheW interface [polypeptide binding]; other site 693982001622 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 693982001623 TRAM domain; Region: TRAM; cl01282 693982001624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982001625 S-adenosylmethionine binding site [chemical binding]; other site 693982001626 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 693982001627 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693982001628 RNA binding surface [nucleotide binding]; other site 693982001629 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 693982001630 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 693982001631 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 693982001632 TPP-binding site; other site 693982001633 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693982001634 PYR/PP interface [polypeptide binding]; other site 693982001635 dimer interface [polypeptide binding]; other site 693982001636 TPP binding site [chemical binding]; other site 693982001637 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693982001638 Pirin-related protein [General function prediction only]; Region: COG1741 693982001639 Pirin; Region: Pirin; pfam02678 693982001640 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 693982001641 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 693982001642 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 693982001643 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 693982001644 putative active site [active] 693982001645 Zn binding site [ion binding]; other site 693982001646 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 693982001647 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 693982001648 NADP binding site [chemical binding]; other site 693982001649 dimer interface [polypeptide binding]; other site 693982001650 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693982001651 active site 693982001652 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693982001653 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 693982001654 dimer interface [polypeptide binding]; other site 693982001655 active site 693982001656 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 693982001657 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693982001658 acyl-activating enzyme (AAE) consensus motif; other site 693982001659 AMP binding site [chemical binding]; other site 693982001660 active site 693982001661 CoA binding site [chemical binding]; other site 693982001662 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 693982001663 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 693982001664 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 693982001665 Walker A/P-loop; other site 693982001666 ATP binding site [chemical binding]; other site 693982001667 Q-loop/lid; other site 693982001668 ABC transporter signature motif; other site 693982001669 Walker B; other site 693982001670 D-loop; other site 693982001671 H-loop/switch region; other site 693982001672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 693982001673 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 693982001674 protease TldD; Provisional; Region: tldD; PRK10735 693982001675 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 693982001676 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 693982001677 Sporulation related domain; Region: SPOR; pfam05036 693982001678 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 693982001679 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 693982001680 putative active site [active] 693982001681 putative metal binding site [ion binding]; other site 693982001682 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 693982001683 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 693982001684 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 693982001685 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 693982001686 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693982001687 HSP70 interaction site [polypeptide binding]; other site 693982001688 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 693982001689 substrate binding site [polypeptide binding]; other site 693982001690 dimer interface [polypeptide binding]; other site 693982001691 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 693982001692 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 693982001693 NAD binding site [chemical binding]; other site 693982001694 homotetramer interface [polypeptide binding]; other site 693982001695 homodimer interface [polypeptide binding]; other site 693982001696 substrate binding site [chemical binding]; other site 693982001697 active site 693982001698 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693982001699 catalytic core [active] 693982001700 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 693982001701 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 693982001702 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 693982001703 Tetramer interface [polypeptide binding]; other site 693982001704 active site 693982001705 FMN-binding site [chemical binding]; other site 693982001706 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 693982001707 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 693982001708 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 693982001709 dimerization interface [polypeptide binding]; other site 693982001710 active site 693982001711 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 693982001712 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00051 693982001713 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 693982001714 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 693982001715 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 693982001716 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 693982001717 Subunit I/III interface [polypeptide binding]; other site 693982001718 D-pathway; other site 693982001719 Subunit I/VIIc interface [polypeptide binding]; other site 693982001720 Subunit I/IV interface [polypeptide binding]; other site 693982001721 Subunit I/II interface [polypeptide binding]; other site 693982001722 Low-spin heme (heme a) binding site [chemical binding]; other site 693982001723 Subunit I/VIIa interface [polypeptide binding]; other site 693982001724 Subunit I/VIa interface [polypeptide binding]; other site 693982001725 Dimer interface; other site 693982001726 Putative water exit pathway; other site 693982001727 Binuclear center (heme a3/CuB) [ion binding]; other site 693982001728 K-pathway; other site 693982001729 Subunit I/Vb interface [polypeptide binding]; other site 693982001730 Putative proton exit pathway; other site 693982001731 Subunit I/VIb interface; other site 693982001732 Subunit I/VIc interface [polypeptide binding]; other site 693982001733 Electron transfer pathway; other site 693982001734 Subunit I/VIIIb interface [polypeptide binding]; other site 693982001735 Subunit I/VIIb interface [polypeptide binding]; other site 693982001736 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 693982001737 UbiA prenyltransferase family; Region: UbiA; pfam01040 693982001738 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 693982001739 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 693982001740 Subunit III/VIIa interface [polypeptide binding]; other site 693982001741 Phospholipid binding site [chemical binding]; other site 693982001742 Subunit I/III interface [polypeptide binding]; other site 693982001743 Subunit III/VIb interface [polypeptide binding]; other site 693982001744 Subunit III/VIa interface; other site 693982001745 Subunit III/Vb interface [polypeptide binding]; other site 693982001746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 693982001747 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 693982001748 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 693982001749 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 693982001750 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 693982001751 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 693982001752 putative active site [active] 693982001753 putative substrate binding site [chemical binding]; other site 693982001754 ATP binding site [chemical binding]; other site 693982001755 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 693982001756 RNA/DNA hybrid binding site [nucleotide binding]; other site 693982001757 active site 693982001758 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 693982001759 catalytic triad [active] 693982001760 dimer interface [polypeptide binding]; other site 693982001761 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 693982001762 hypothetical protein; Validated; Region: PRK00228 693982001763 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 693982001764 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 693982001765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982001766 PAS fold; Region: PAS_3; pfam08447 693982001767 putative active site [active] 693982001768 heme pocket [chemical binding]; other site 693982001769 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693982001770 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982001771 metal binding site [ion binding]; metal-binding site 693982001772 active site 693982001773 I-site; other site 693982001774 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693982001775 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693982001776 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693982001777 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693982001778 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693982001779 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693982001780 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 693982001781 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 693982001782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982001783 catalytic residue [active] 693982001784 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 693982001785 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 693982001786 dimerization interface [polypeptide binding]; other site 693982001787 ligand binding site [chemical binding]; other site 693982001788 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 693982001789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982001790 motif II; other site 693982001791 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982001792 dimerization interface [polypeptide binding]; other site 693982001793 putative DNA binding site [nucleotide binding]; other site 693982001794 putative Zn2+ binding site [ion binding]; other site 693982001795 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 693982001796 DNA methylase; Region: N6_N4_Mtase; pfam01555 693982001797 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 693982001798 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 693982001799 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 693982001800 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693982001801 minor groove reading motif; other site 693982001802 helix-hairpin-helix signature motif; other site 693982001803 substrate binding pocket [chemical binding]; other site 693982001804 active site 693982001805 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 693982001806 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 693982001807 DNA binding and oxoG recognition site [nucleotide binding] 693982001808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 693982001809 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 693982001810 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 693982001811 catalytic residues [active] 693982001812 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 693982001813 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 693982001814 Walker A/P-loop; other site 693982001815 ATP binding site [chemical binding]; other site 693982001816 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 693982001817 ABC transporter signature motif; other site 693982001818 Walker B; other site 693982001819 D-loop; other site 693982001820 H-loop/switch region; other site 693982001821 pyruvate phosphate dikinase; Provisional; Region: PRK09279 693982001822 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 693982001823 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693982001824 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693982001825 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 693982001826 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693982001827 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 693982001828 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 693982001829 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693982001830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982001831 non-specific DNA binding site [nucleotide binding]; other site 693982001832 salt bridge; other site 693982001833 sequence-specific DNA binding site [nucleotide binding]; other site 693982001834 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 693982001835 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 693982001836 CysD dimerization site [polypeptide binding]; other site 693982001837 G1 box; other site 693982001838 putative GEF interaction site [polypeptide binding]; other site 693982001839 GTP/Mg2+ binding site [chemical binding]; other site 693982001840 Switch I region; other site 693982001841 G2 box; other site 693982001842 G3 box; other site 693982001843 Switch II region; other site 693982001844 G4 box; other site 693982001845 G5 box; other site 693982001846 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 693982001847 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 693982001848 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 693982001849 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693982001850 Active Sites [active] 693982001851 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 693982001852 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693982001853 Active Sites [active] 693982001854 choline dehydrogenase; Validated; Region: PRK02106 693982001855 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 693982001856 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 693982001857 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693982001858 NAD(P) binding site [chemical binding]; other site 693982001859 catalytic residues [active] 693982001860 Sulfatase; Region: Sulfatase; cl17466 693982001861 choline-sulfatase; Region: chol_sulfatase; TIGR03417 693982001862 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 693982001863 transcriptional regulator BetI; Validated; Region: PRK00767 693982001864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982001865 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 693982001866 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 693982001867 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693982001868 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 693982001869 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693982001870 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982001871 metal binding site [ion binding]; metal-binding site 693982001872 active site 693982001873 I-site; other site 693982001874 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 693982001875 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 693982001876 NAD(P) binding site [chemical binding]; other site 693982001877 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 693982001878 L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448 693982001879 glutathionine S-transferase; Provisional; Region: PRK10542 693982001880 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 693982001881 C-terminal domain interface [polypeptide binding]; other site 693982001882 GSH binding site (G-site) [chemical binding]; other site 693982001883 dimer interface [polypeptide binding]; other site 693982001884 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 693982001885 dimer interface [polypeptide binding]; other site 693982001886 N-terminal domain interface [polypeptide binding]; other site 693982001887 substrate binding pocket (H-site) [chemical binding]; other site 693982001888 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693982001889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982001890 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693982001891 dimerization interface [polypeptide binding]; other site 693982001892 substrate binding pocket [chemical binding]; other site 693982001893 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982001894 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 693982001895 putative C-terminal domain interface [polypeptide binding]; other site 693982001896 putative GSH binding site (G-site) [chemical binding]; other site 693982001897 putative dimer interface [polypeptide binding]; other site 693982001898 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 693982001899 dimer interface [polypeptide binding]; other site 693982001900 N-terminal domain interface [polypeptide binding]; other site 693982001901 putative substrate binding pocket (H-site) [chemical binding]; other site 693982001902 PAS fold; Region: PAS_4; pfam08448 693982001903 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693982001904 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 693982001905 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693982001906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982001907 metal binding site [ion binding]; metal-binding site 693982001908 active site 693982001909 I-site; other site 693982001910 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693982001911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 693982001912 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693982001913 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693982001914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982001915 putative Zn2+ binding site [ion binding]; other site 693982001916 putative DNA binding site [nucleotide binding]; other site 693982001917 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 693982001918 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 693982001919 PhnA protein; Region: PhnA; pfam03831 693982001920 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 693982001921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 693982001922 Walker A motif; other site 693982001923 ATP binding site [chemical binding]; other site 693982001924 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982001925 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982001926 active site 693982001927 catalytic tetrad [active] 693982001928 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 693982001929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982001930 S-adenosylmethionine binding site [chemical binding]; other site 693982001931 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 693982001932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982001933 motif II; other site 693982001934 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 693982001935 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 693982001936 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 693982001937 putative NAD(P) binding site [chemical binding]; other site 693982001938 catalytic Zn binding site [ion binding]; other site 693982001939 structural Zn binding site [ion binding]; other site 693982001940 aminotransferase; Provisional; Region: PRK13356 693982001941 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 693982001942 homodimer interface [polypeptide binding]; other site 693982001943 substrate-cofactor binding pocket; other site 693982001944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982001945 catalytic residue [active] 693982001946 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 693982001947 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982001948 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 693982001949 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 693982001950 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 693982001951 Predicted transcriptional regulator [Transcription]; Region: COG2378 693982001952 HTH domain; Region: HTH_11; pfam08279 693982001953 WYL domain; Region: WYL; pfam13280 693982001954 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693982001955 Cytochrome c556 [Energy production and conversion]; Region: COG3909 693982001956 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693982001957 Cytochrome c; Region: Cytochrom_C; cl11414 693982001958 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693982001959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982001960 Coenzyme A binding pocket [chemical binding]; other site 693982001961 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 693982001962 DNA binding residues [nucleotide binding] 693982001963 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 693982001964 dimer interface [polypeptide binding]; other site 693982001965 putative metal binding site [ion binding]; other site 693982001966 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 693982001967 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 693982001968 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 693982001969 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 693982001970 Trp docking motif [polypeptide binding]; other site 693982001971 putative active site [active] 693982001972 Uncharacterized conserved protein [Function unknown]; Region: COG0397 693982001973 hypothetical protein; Validated; Region: PRK00029 693982001974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 693982001975 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 693982001976 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693982001977 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 693982001978 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 693982001979 putative metal binding site [ion binding]; other site 693982001980 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 693982001981 active site 693982001982 metal binding site [ion binding]; metal-binding site 693982001983 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693982001984 Ligand Binding Site [chemical binding]; other site 693982001985 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 693982001986 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 693982001987 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 693982001988 methionine sulfoxide reductase B; Provisional; Region: PRK00222 693982001989 SelR domain; Region: SelR; pfam01641 693982001990 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 693982001991 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 693982001992 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693982001993 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 693982001994 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 693982001995 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658 693982001996 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 693982001997 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693982001998 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 693982001999 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 693982002000 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 693982002001 Predicted transcriptional regulator [Transcription]; Region: COG4957 693982002002 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 693982002003 two-component sensor protein; Provisional; Region: cpxA; PRK09470 693982002004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982002005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982002006 dimer interface [polypeptide binding]; other site 693982002007 phosphorylation site [posttranslational modification] 693982002008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982002009 ATP binding site [chemical binding]; other site 693982002010 Mg2+ binding site [ion binding]; other site 693982002011 G-X-G motif; other site 693982002012 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 693982002013 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982002014 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982002015 Uncharacterized conserved protein [Function unknown]; Region: COG5447 693982002016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 693982002017 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 693982002018 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 693982002019 Bacterial SH3 domain; Region: SH3_3; pfam08239 693982002020 Predicted integral membrane protein [Function unknown]; Region: COG5436 693982002021 Uncharacterized conserved protein [Function unknown]; Region: COG5402 693982002022 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 693982002023 Transglycosylase; Region: Transgly; pfam00912 693982002024 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693982002025 hypothetical protein; Provisional; Region: PRK05170 693982002026 Protein of unknown function (DUF419); Region: DUF419; pfam04237 693982002027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982002028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982002029 active site 693982002030 phosphorylation site [posttranslational modification] 693982002031 intermolecular recognition site; other site 693982002032 dimerization interface [polypeptide binding]; other site 693982002033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982002034 DNA binding site [nucleotide binding] 693982002035 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982002036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982002037 ATP binding site [chemical binding]; other site 693982002038 Mg2+ binding site [ion binding]; other site 693982002039 G-X-G motif; other site 693982002040 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 693982002041 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 693982002042 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 693982002043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982002044 binding surface 693982002045 TPR motif; other site 693982002046 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 693982002047 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 693982002048 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 693982002049 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693982002050 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693982002051 protein binding site [polypeptide binding]; other site 693982002052 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693982002053 protein binding site [polypeptide binding]; other site 693982002054 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982002055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982002056 active site 693982002057 phosphorylation site [posttranslational modification] 693982002058 intermolecular recognition site; other site 693982002059 dimerization interface [polypeptide binding]; other site 693982002060 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982002061 DNA binding site [nucleotide binding] 693982002062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982002063 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693982002064 dimerization interface [polypeptide binding]; other site 693982002065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982002066 dimer interface [polypeptide binding]; other site 693982002067 phosphorylation site [posttranslational modification] 693982002068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982002069 ATP binding site [chemical binding]; other site 693982002070 Mg2+ binding site [ion binding]; other site 693982002071 G-X-G motif; other site 693982002072 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 693982002073 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693982002074 metal binding triad; other site 693982002075 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 693982002076 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693982002077 metal binding triad; other site 693982002078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982002079 PAS fold; Region: PAS_3; pfam08447 693982002080 putative active site [active] 693982002081 heme pocket [chemical binding]; other site 693982002082 PAS fold; Region: PAS_7; pfam12860 693982002083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982002084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982002085 dimer interface [polypeptide binding]; other site 693982002086 phosphorylation site [posttranslational modification] 693982002087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982002088 ATP binding site [chemical binding]; other site 693982002089 Mg2+ binding site [ion binding]; other site 693982002090 G-X-G motif; other site 693982002091 aminopeptidase N; Provisional; Region: pepN; PRK14015 693982002092 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 693982002093 active site 693982002094 Zn binding site [ion binding]; other site 693982002095 EamA-like transporter family; Region: EamA; pfam00892 693982002096 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693982002097 EamA-like transporter family; Region: EamA; pfam00892 693982002098 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 693982002099 Fe-S cluster binding site [ion binding]; other site 693982002100 active site 693982002101 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 693982002102 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 693982002103 nucleotide binding site [chemical binding]; other site 693982002104 putative NEF/HSP70 interaction site [polypeptide binding]; other site 693982002105 SBD interface [polypeptide binding]; other site 693982002106 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 693982002107 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693982002108 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 693982002109 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 693982002110 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 693982002111 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693982002112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982002113 dimer interface [polypeptide binding]; other site 693982002114 conserved gate region; other site 693982002115 putative PBP binding loops; other site 693982002116 ABC-ATPase subunit interface; other site 693982002117 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 693982002118 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 693982002119 putative NAD(P) binding site [chemical binding]; other site 693982002120 dimer interface [polypeptide binding]; other site 693982002121 Predicted transcriptional regulators [Transcription]; Region: COG1733 693982002122 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 693982002123 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 693982002124 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 693982002125 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 693982002126 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 693982002127 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693982002128 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 693982002129 Ligand binding site; other site 693982002130 Putative Catalytic site; other site 693982002131 DXD motif; other site 693982002132 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 693982002133 AMP nucleosidase; Provisional; Region: PRK08292 693982002134 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 693982002135 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 693982002136 Uncharacterized conserved protein [Function unknown]; Region: COG1742 693982002137 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 693982002138 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 693982002139 C-terminal domain interface [polypeptide binding]; other site 693982002140 GSH binding site (G-site) [chemical binding]; other site 693982002141 dimer interface [polypeptide binding]; other site 693982002142 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 693982002143 N-terminal domain interface [polypeptide binding]; other site 693982002144 putative dimer interface [polypeptide binding]; other site 693982002145 active site 693982002146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 693982002147 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693982002148 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 693982002149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982002150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982002151 homodimer interface [polypeptide binding]; other site 693982002152 catalytic residue [active] 693982002153 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693982002154 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693982002155 active site 693982002156 Int/Topo IB signature motif; other site 693982002157 catalytic residues [active] 693982002158 DNA binding site [nucleotide binding] 693982002159 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 693982002160 RecT family; Region: RecT; cl04285 693982002161 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 693982002162 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693982002163 Catalytic site [active] 693982002164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982002165 sequence-specific DNA binding site [nucleotide binding]; other site 693982002166 salt bridge; other site 693982002167 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693982002168 Predicted transcriptional regulator [Transcription]; Region: COG2932 693982002169 Catalytic site [active] 693982002170 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 693982002171 HNH endonuclease; Region: HNH_3; pfam13392 693982002172 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 693982002173 GcrA cell cycle regulator; Region: GcrA; cl11564 693982002174 Transcription termination factor nusG; Region: NusG; pfam02357 693982002175 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693982002176 Terminase small subunit; Region: Terminase_2; cl01513 693982002177 Terminase-like family; Region: Terminase_6; pfam03237 693982002178 Phage terminase large subunit; Region: Terminase_3; cl12054 693982002179 Uncharacterized conserved protein [Function unknown]; Region: COG5323 693982002180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567 693982002181 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 693982002182 hypothetical protein; Provisional; Region: 57B; PHA02574 693982002183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 693982002184 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 693982002185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 693982002186 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 693982002187 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 693982002188 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 693982002189 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 693982002190 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 693982002191 active site 693982002192 oxyanion hole [active] 693982002193 catalytic triad [active] 693982002194 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693982002195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982002196 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693982002197 active site 693982002198 Predicted chitinase [General function prediction only]; Region: COG3179 693982002199 catalytic residue [active] 693982002200 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982002201 Transposase, Mutator family; Region: Transposase_mut; pfam00872 693982002202 MULE transposase domain; Region: MULE; pfam10551 693982002203 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693982002204 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693982002205 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 693982002206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982002207 sequence-specific DNA binding site [nucleotide binding]; other site 693982002208 salt bridge; other site 693982002209 Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549 693982002210 Porin subfamily; Region: Porin_2; pfam02530 693982002211 Porin subfamily; Region: Porin_2; pfam02530 693982002212 CopC domain; Region: CopC; cl01012 693982002213 BA14K-like protein; Region: BA14K; pfam07886 693982002214 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 693982002215 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693982002216 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693982002217 catalytic residue [active] 693982002218 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 693982002219 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 693982002220 dimer interface [polypeptide binding]; other site 693982002221 active site 693982002222 catalytic residue [active] 693982002223 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 693982002224 SmpB-tmRNA interface; other site 693982002225 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 693982002226 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 693982002227 Autotransporter beta-domain; Region: Autotransporter; pfam03797 693982002228 Uncharacterized conserved protein [Function unknown]; Region: COG1432 693982002229 LabA_like proteins; Region: LabA; cd10911 693982002230 putative metal binding site [ion binding]; other site 693982002231 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 693982002232 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 693982002233 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693982002234 Zn2+ binding site [ion binding]; other site 693982002235 Mg2+ binding site [ion binding]; other site 693982002236 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 693982002237 synthetase active site [active] 693982002238 NTP binding site [chemical binding]; other site 693982002239 metal binding site [ion binding]; metal-binding site 693982002240 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 693982002241 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 693982002242 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 693982002243 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 693982002244 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 693982002245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 693982002246 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 693982002247 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 693982002248 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693982002249 Catalytic site [active] 693982002250 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693982002251 ribonuclease III; Reviewed; Region: PRK12371 693982002252 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 693982002253 dimerization interface [polypeptide binding]; other site 693982002254 active site 693982002255 metal binding site [ion binding]; metal-binding site 693982002256 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 693982002257 dsRNA binding site [nucleotide binding]; other site 693982002258 GTPase Era; Reviewed; Region: era; PRK00089 693982002259 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 693982002260 G1 box; other site 693982002261 GTP/Mg2+ binding site [chemical binding]; other site 693982002262 Switch I region; other site 693982002263 G2 box; other site 693982002264 Switch II region; other site 693982002265 G3 box; other site 693982002266 G4 box; other site 693982002267 G5 box; other site 693982002268 KH domain; Region: KH_2; pfam07650 693982002269 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 693982002270 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693982002271 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 693982002272 ArsC family; Region: ArsC; pfam03960 693982002273 catalytic residues [active] 693982002274 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 693982002275 amphipathic channel; other site 693982002276 Asn-Pro-Ala signature motifs; other site 693982002277 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982002278 dimerization interface [polypeptide binding]; other site 693982002279 putative DNA binding site [nucleotide binding]; other site 693982002280 putative Zn2+ binding site [ion binding]; other site 693982002281 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 693982002282 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 693982002283 putative active site [active] 693982002284 catalytic site [active] 693982002285 putative metal binding site [ion binding]; other site 693982002286 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 693982002287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982002288 S-adenosylmethionine binding site [chemical binding]; other site 693982002289 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 693982002290 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 693982002291 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 693982002292 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 693982002293 RNA binding site [nucleotide binding]; other site 693982002294 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 693982002295 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693982002296 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 693982002297 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 693982002298 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982002299 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 693982002300 putative NAD(P) binding site [chemical binding]; other site 693982002301 active site 693982002302 putative substrate binding site [chemical binding]; other site 693982002303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982002304 dimerization interface [polypeptide binding]; other site 693982002305 putative DNA binding site [nucleotide binding]; other site 693982002306 putative Zn2+ binding site [ion binding]; other site 693982002307 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 693982002308 hydrophobic ligand binding site; other site 693982002309 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 693982002310 active site 693982002311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 693982002312 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693982002313 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 693982002314 Recombination protein O N terminal; Region: RecO_N; pfam11967 693982002315 Recombination protein O C terminal; Region: RecO_C; pfam02565 693982002316 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 693982002317 Predicted membrane protein [Function unknown]; Region: COG5373 693982002318 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 693982002319 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693982002320 Zn2+ binding site [ion binding]; other site 693982002321 Mg2+ binding site [ion binding]; other site 693982002322 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 693982002323 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 693982002324 MOSC domain; Region: MOSC; pfam03473 693982002325 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 693982002326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982002327 putative substrate translocation pore; other site 693982002328 quinolinate synthetase; Provisional; Region: PRK09375 693982002329 L-aspartate oxidase; Provisional; Region: PRK07512 693982002330 L-aspartate oxidase; Provisional; Region: PRK06175 693982002331 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693982002332 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 693982002333 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 693982002334 dimerization interface [polypeptide binding]; other site 693982002335 active site 693982002336 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 693982002337 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 693982002338 E-class dimer interface [polypeptide binding]; other site 693982002339 P-class dimer interface [polypeptide binding]; other site 693982002340 active site 693982002341 Cu2+ binding site [ion binding]; other site 693982002342 Zn2+ binding site [ion binding]; other site 693982002343 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 693982002344 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982002345 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982002346 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 693982002347 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 693982002348 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 693982002349 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 693982002350 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 693982002351 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693982002352 Predicted secreted protein [Function unknown]; Region: COG5451 693982002353 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 693982002354 nudix motif; other site 693982002355 Uncharacterized conserved protein [Function unknown]; Region: COG2135 693982002356 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 693982002357 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 693982002358 active site 693982002359 HIGH motif; other site 693982002360 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 693982002361 KMSKS motif; other site 693982002362 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 693982002363 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693982002364 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693982002365 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693982002366 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 693982002367 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 693982002368 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 693982002369 active site 693982002370 catalytic residues [active] 693982002371 metal binding site [ion binding]; metal-binding site 693982002372 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 693982002373 Predicted permeases [General function prediction only]; Region: RarD; COG2962 693982002374 EamA-like transporter family; Region: EamA; cl17759 693982002375 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 693982002376 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 693982002377 Transthyretin-like family; Region: DUF290; pfam01060 693982002378 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 693982002379 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693982002380 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693982002381 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 693982002382 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 693982002383 Walker A/P-loop; other site 693982002384 ATP binding site [chemical binding]; other site 693982002385 Q-loop/lid; other site 693982002386 ABC transporter signature motif; other site 693982002387 Walker B; other site 693982002388 D-loop; other site 693982002389 H-loop/switch region; other site 693982002390 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 693982002391 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 693982002392 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 693982002393 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 693982002394 classical (c) SDRs; Region: SDR_c; cd05233 693982002395 NAD(P) binding site [chemical binding]; other site 693982002396 active site 693982002397 amidophosphoribosyltransferase; Provisional; Region: PRK09123 693982002398 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 693982002399 active site 693982002400 tetramer interface [polypeptide binding]; other site 693982002401 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693982002402 active site 693982002403 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 693982002404 Colicin V production protein; Region: Colicin_V; pfam02674 693982002405 DNA repair protein RadA; Provisional; Region: PRK11823 693982002406 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 693982002407 Walker A motif/ATP binding site; other site 693982002408 ATP binding site [chemical binding]; other site 693982002409 Walker B motif; other site 693982002410 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 693982002411 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 693982002412 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 693982002413 active site 693982002414 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693982002415 dimer interface [polypeptide binding]; other site 693982002416 substrate binding site [chemical binding]; other site 693982002417 catalytic residues [active] 693982002418 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693982002419 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693982002420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982002421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982002422 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 693982002423 Predicted membrane protein [Function unknown]; Region: COG4541 693982002424 replicative DNA helicase; Provisional; Region: PRK09165 693982002425 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 693982002426 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 693982002427 Walker A motif; other site 693982002428 ATP binding site [chemical binding]; other site 693982002429 Walker B motif; other site 693982002430 DNA binding loops [nucleotide binding] 693982002431 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693982002432 MarR family; Region: MarR_2; pfam12802 693982002433 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 693982002434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982002435 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693982002436 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982002437 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982002438 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 693982002439 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 693982002440 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 693982002441 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 693982002442 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 693982002443 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 693982002444 dimerization interface [polypeptide binding]; other site 693982002445 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982002446 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982002447 active site 693982002448 catalytic tetrad [active] 693982002449 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 693982002450 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 693982002451 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 693982002452 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 693982002453 NAD(P) binding site [chemical binding]; other site 693982002454 homotetramer interface [polypeptide binding]; other site 693982002455 homodimer interface [polypeptide binding]; other site 693982002456 active site 693982002457 acyl carrier protein; Provisional; Region: acpP; PRK00982 693982002458 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 693982002459 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693982002460 dimer interface [polypeptide binding]; other site 693982002461 active site 693982002462 YceG-like family; Region: YceG; pfam02618 693982002463 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 693982002464 dimerization interface [polypeptide binding]; other site 693982002465 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 693982002466 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 693982002467 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 693982002468 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 693982002469 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 693982002470 catalytic site [active] 693982002471 G-X2-G-X-G-K; other site 693982002472 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693982002473 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693982002474 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693982002475 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 693982002476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982002477 S-adenosylmethionine binding site [chemical binding]; other site 693982002478 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 693982002479 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 693982002480 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 693982002481 SurA N-terminal domain; Region: SurA_N; pfam09312 693982002482 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 693982002483 Organic solvent tolerance protein; Region: OstA_C; pfam04453 693982002484 Predicted permeases [General function prediction only]; Region: COG0795 693982002485 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 693982002486 Predicted permeases [General function prediction only]; Region: COG0795 693982002487 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 693982002488 multifunctional aminopeptidase A; Provisional; Region: PRK00913 693982002489 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 693982002490 interface (dimer of trimers) [polypeptide binding]; other site 693982002491 Substrate-binding/catalytic site; other site 693982002492 Zn-binding sites [ion binding]; other site 693982002493 DNA polymerase III subunit chi; Validated; Region: PRK05728 693982002494 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982002495 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982002496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982002497 Coenzyme A binding pocket [chemical binding]; other site 693982002498 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 693982002499 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693982002500 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693982002501 ABC transporter; Region: ABC_tran_2; pfam12848 693982002502 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693982002503 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 693982002504 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693982002505 acyl-activating enzyme (AAE) consensus motif; other site 693982002506 AMP binding site [chemical binding]; other site 693982002507 active site 693982002508 CoA binding site [chemical binding]; other site 693982002509 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 693982002510 Acyltransferase family; Region: Acyl_transf_3; pfam01757 693982002511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 693982002512 DinB superfamily; Region: DinB_2; pfam12867 693982002513 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 693982002514 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982002515 putative C-terminal domain interface [polypeptide binding]; other site 693982002516 putative GSH binding site (G-site) [chemical binding]; other site 693982002517 putative dimer interface [polypeptide binding]; other site 693982002518 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 693982002519 putative N-terminal domain interface [polypeptide binding]; other site 693982002520 putative dimer interface [polypeptide binding]; other site 693982002521 putative substrate binding pocket (H-site) [chemical binding]; other site 693982002522 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 693982002523 active site 693982002524 multimer interface [polypeptide binding]; other site 693982002525 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 693982002526 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 693982002527 CGNR zinc finger; Region: zf-CGNR; pfam11706 693982002528 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 693982002529 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982002530 TM-ABC transporter signature motif; other site 693982002531 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 693982002532 MoaE homodimer interface [polypeptide binding]; other site 693982002533 MoaD interaction [polypeptide binding]; other site 693982002534 active site residues [active] 693982002535 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 693982002536 MoaE interaction surface [polypeptide binding]; other site 693982002537 MoeB interaction surface [polypeptide binding]; other site 693982002538 thiocarboxylated glycine; other site 693982002539 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 693982002540 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 693982002541 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 693982002542 GIY-YIG motif/motif A; other site 693982002543 active site 693982002544 catalytic site [active] 693982002545 putative DNA binding site [nucleotide binding]; other site 693982002546 metal binding site [ion binding]; metal-binding site 693982002547 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 693982002548 short chain dehydrogenase; Provisional; Region: PRK09134 693982002549 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 693982002550 NADP binding site [chemical binding]; other site 693982002551 substrate binding pocket [chemical binding]; other site 693982002552 active site 693982002553 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 693982002554 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982002555 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 693982002556 putative C-terminal domain interface [polypeptide binding]; other site 693982002557 putative GSH binding site (G-site) [chemical binding]; other site 693982002558 putative dimer interface [polypeptide binding]; other site 693982002559 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 693982002560 N-terminal domain interface [polypeptide binding]; other site 693982002561 dimer interface [polypeptide binding]; other site 693982002562 putative substrate binding pocket (H-site) [chemical binding]; other site 693982002563 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 693982002564 B1 nucleotide binding pocket [chemical binding]; other site 693982002565 B2 nucleotide binding pocket [chemical binding]; other site 693982002566 CAS motifs; other site 693982002567 active site 693982002568 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 693982002569 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 693982002570 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 693982002571 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 693982002572 putative [4Fe-4S] binding site [ion binding]; other site 693982002573 putative molybdopterin cofactor binding site [chemical binding]; other site 693982002574 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 693982002575 putative molybdopterin cofactor binding site; other site 693982002576 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 693982002577 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693982002578 dimer interface [polypeptide binding]; other site 693982002579 ADP-ribose binding site [chemical binding]; other site 693982002580 active site 693982002581 nudix motif; other site 693982002582 metal binding site [ion binding]; metal-binding site 693982002583 Predicted integral membrane protein [Function unknown]; Region: COG0392 693982002584 Uncharacterized conserved protein [Function unknown]; Region: COG2898 693982002585 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 693982002586 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 693982002587 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 693982002588 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 693982002589 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 693982002590 active site 693982002591 substrate binding site [chemical binding]; other site 693982002592 cosubstrate binding site; other site 693982002593 catalytic site [active] 693982002594 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 693982002595 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 693982002596 dimerization interface [polypeptide binding]; other site 693982002597 putative ATP binding site [chemical binding]; other site 693982002598 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693982002599 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693982002600 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 693982002601 hypothetical protein; Validated; Region: PRK09087 693982002602 polyphosphate kinase; Provisional; Region: PRK05443 693982002603 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 693982002604 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 693982002605 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 693982002606 putative domain interface [polypeptide binding]; other site 693982002607 putative active site [active] 693982002608 catalytic site [active] 693982002609 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 693982002610 putative domain interface [polypeptide binding]; other site 693982002611 putative active site [active] 693982002612 catalytic site [active] 693982002613 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 693982002614 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 693982002615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 693982002616 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982002617 cyclase homology domain; Region: CHD; cd07302 693982002618 nucleotidyl binding site; other site 693982002619 metal binding site [ion binding]; metal-binding site 693982002620 dimer interface [polypeptide binding]; other site 693982002621 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 693982002622 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 693982002623 catalytic site [active] 693982002624 putative active site [active] 693982002625 putative substrate binding site [chemical binding]; other site 693982002626 HRDC domain; Region: HRDC; pfam00570 693982002627 L-ascorbate oxidase, plant type; Region: ascorbase; TIGR03388 693982002628 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 693982002629 Multicopper oxidase; Region: Cu-oxidase; pfam00394 693982002630 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 693982002631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982002632 putative substrate translocation pore; other site 693982002633 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 693982002634 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 693982002635 dimer interface [polypeptide binding]; other site 693982002636 anticodon binding site; other site 693982002637 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 693982002638 homodimer interface [polypeptide binding]; other site 693982002639 motif 1; other site 693982002640 active site 693982002641 motif 2; other site 693982002642 GAD domain; Region: GAD; pfam02938 693982002643 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693982002644 active site 693982002645 motif 3; other site 693982002646 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 693982002647 active site 693982002648 catalytic residue [active] 693982002649 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 693982002650 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 693982002651 ring oligomerisation interface [polypeptide binding]; other site 693982002652 ATP/Mg binding site [chemical binding]; other site 693982002653 stacking interactions; other site 693982002654 hinge regions; other site 693982002655 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 693982002656 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 693982002657 CAP-like domain; other site 693982002658 active site 693982002659 primary dimer interface [polypeptide binding]; other site 693982002660 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693982002661 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 693982002662 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 693982002663 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 693982002664 Predicted membrane protein/domain [Function unknown]; Region: COG1714 693982002665 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 693982002666 dimer interface [polypeptide binding]; other site 693982002667 allosteric magnesium binding site [ion binding]; other site 693982002668 active site 693982002669 aspartate-rich active site metal binding site; other site 693982002670 Schiff base residues; other site 693982002671 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693982002672 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 693982002673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 693982002674 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982002675 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693982002676 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693982002677 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 693982002678 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 693982002679 dimer interface [polypeptide binding]; other site 693982002680 active site 693982002681 glycine-pyridoxal phosphate binding site [chemical binding]; other site 693982002682 folate binding site [chemical binding]; other site 693982002683 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 693982002684 ATP cone domain; Region: ATP-cone; pfam03477 693982002685 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 693982002686 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 693982002687 catalytic motif [active] 693982002688 Zn binding site [ion binding]; other site 693982002689 RibD C-terminal domain; Region: RibD_C; cl17279 693982002690 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 693982002691 Lumazine binding domain; Region: Lum_binding; pfam00677 693982002692 Lumazine binding domain; Region: Lum_binding; pfam00677 693982002693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693982002694 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 693982002695 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 693982002696 homopentamer interface [polypeptide binding]; other site 693982002697 active site 693982002698 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 693982002699 putative RNA binding site [nucleotide binding]; other site 693982002700 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 693982002701 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 693982002702 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 693982002703 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 693982002704 Uncharacterized conserved protein [Function unknown]; Region: COG5452 693982002705 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 693982002706 putative phosphate acyltransferase; Provisional; Region: PRK05331 693982002707 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 693982002708 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 693982002709 dimer interface [polypeptide binding]; other site 693982002710 active site 693982002711 CoA binding pocket [chemical binding]; other site 693982002712 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693982002713 IHF dimer interface [polypeptide binding]; other site 693982002714 IHF - DNA interface [nucleotide binding]; other site 693982002715 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 693982002716 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 693982002717 DNA binding residues [nucleotide binding] 693982002718 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 693982002719 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982002720 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 693982002721 O-Antigen ligase; Region: Wzy_C; pfam04932 693982002722 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 693982002723 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 693982002724 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 693982002725 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982002726 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 693982002727 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 693982002728 SLBB domain; Region: SLBB; pfam10531 693982002729 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 693982002730 Chain length determinant protein; Region: Wzz; pfam02706 693982002731 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 693982002732 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 693982002733 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 693982002734 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 693982002735 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 693982002736 trimer interface [polypeptide binding]; other site 693982002737 active site 693982002738 substrate binding site [chemical binding]; other site 693982002739 CoA binding site [chemical binding]; other site 693982002740 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 693982002741 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 693982002742 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 693982002743 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 693982002744 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693982002745 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 693982002746 agmatinase; Region: agmatinase; TIGR01230 693982002747 oligomer interface [polypeptide binding]; other site 693982002748 putative active site [active] 693982002749 Mn binding site [ion binding]; other site 693982002750 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 693982002751 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 693982002752 23S rRNA interface [nucleotide binding]; other site 693982002753 L3 interface [polypeptide binding]; other site 693982002754 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693982002755 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 693982002756 CoenzymeA binding site [chemical binding]; other site 693982002757 subunit interaction site [polypeptide binding]; other site 693982002758 PHB binding site; other site 693982002759 enoyl-CoA hydratase; Validated; Region: PRK08139 693982002760 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693982002761 substrate binding site [chemical binding]; other site 693982002762 oxyanion hole (OAH) forming residues; other site 693982002763 trimer interface [polypeptide binding]; other site 693982002764 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 693982002765 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 693982002766 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 693982002767 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693982002768 homodimer interface [polypeptide binding]; other site 693982002769 substrate-cofactor binding pocket; other site 693982002770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982002771 catalytic residue [active] 693982002772 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 693982002773 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 693982002774 Cytochrome P450; Region: p450; cl12078 693982002775 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 693982002776 putative catalytic site [active] 693982002777 putative metal binding site [ion binding]; other site 693982002778 putative phosphate binding site [ion binding]; other site 693982002779 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 693982002780 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 693982002781 putative active site [active] 693982002782 catalytic site [active] 693982002783 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 693982002784 putative active site [active] 693982002785 catalytic site [active] 693982002786 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 693982002787 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 693982002788 oligomer interface [polypeptide binding]; other site 693982002789 active site residues [active] 693982002790 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 693982002791 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 693982002792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982002793 Walker A motif; other site 693982002794 ATP binding site [chemical binding]; other site 693982002795 Walker B motif; other site 693982002796 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693982002797 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 693982002798 Found in ATP-dependent protease La (LON); Region: LON; smart00464 693982002799 Found in ATP-dependent protease La (LON); Region: LON; smart00464 693982002800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982002801 Walker A motif; other site 693982002802 ATP binding site [chemical binding]; other site 693982002803 Walker B motif; other site 693982002804 arginine finger; other site 693982002805 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 693982002806 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693982002807 IHF dimer interface [polypeptide binding]; other site 693982002808 IHF - DNA interface [nucleotide binding]; other site 693982002809 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 693982002810 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693982002811 MarR family; Region: MarR; pfam01047 693982002812 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 693982002813 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 693982002814 active site 693982002815 metal binding site [ion binding]; metal-binding site 693982002816 DNA binding site [nucleotide binding] 693982002817 Uncharacterized conserved protein [Function unknown]; Region: COG4717 693982002818 P-loop containing region of AAA domain; Region: AAA_29; cl17516 693982002819 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 693982002820 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 693982002821 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 693982002822 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 693982002823 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 693982002824 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 693982002825 NADH dehydrogenase subunit D; Validated; Region: PRK06075 693982002826 NADH dehydrogenase subunit E; Validated; Region: PRK07539 693982002827 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 693982002828 putative dimer interface [polypeptide binding]; other site 693982002829 [2Fe-2S] cluster binding site [ion binding]; other site 693982002830 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 693982002831 SLBB domain; Region: SLBB; pfam10531 693982002832 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 693982002833 Uncharacterized conserved protein [Function unknown]; Region: COG3743 693982002834 NADH dehydrogenase subunit G; Validated; Region: PRK09130 693982002835 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982002836 catalytic loop [active] 693982002837 iron binding site [ion binding]; other site 693982002838 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 693982002839 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 693982002840 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 693982002841 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 693982002842 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 693982002843 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 693982002844 4Fe-4S binding domain; Region: Fer4; pfam00037 693982002845 4Fe-4S binding domain; Region: Fer4; pfam00037 693982002846 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 693982002847 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 693982002848 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 693982002849 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 693982002850 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 693982002851 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 693982002852 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693982002853 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 693982002854 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693982002855 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 693982002856 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693982002857 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 693982002858 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 693982002859 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 693982002860 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 693982002861 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693982002862 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 693982002863 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982002864 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 693982002865 dimer interface [polypeptide binding]; other site 693982002866 substrate binding site [chemical binding]; other site 693982002867 metal binding site [ion binding]; metal-binding site 693982002868 Predicted secreted protein [Function unknown]; Region: COG5454 693982002869 prolyl-tRNA synthetase; Provisional; Region: PRK12325 693982002870 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 693982002871 dimer interface [polypeptide binding]; other site 693982002872 motif 1; other site 693982002873 active site 693982002874 motif 2; other site 693982002875 motif 3; other site 693982002876 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 693982002877 anticodon binding site; other site 693982002878 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 693982002879 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693982002880 FtsX-like permease family; Region: FtsX; pfam02687 693982002881 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693982002882 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693982002883 Walker A/P-loop; other site 693982002884 ATP binding site [chemical binding]; other site 693982002885 Q-loop/lid; other site 693982002886 ABC transporter signature motif; other site 693982002887 Walker B; other site 693982002888 D-loop; other site 693982002889 H-loop/switch region; other site 693982002890 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 693982002891 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 693982002892 putative active site [active] 693982002893 putative PHP Thumb interface [polypeptide binding]; other site 693982002894 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 693982002895 generic binding surface II; other site 693982002896 generic binding surface I; other site 693982002897 hypothetical protein; Provisional; Region: PRK06132 693982002898 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693982002899 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 693982002900 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982002901 DNA polymerase IV; Provisional; Region: PRK02794 693982002902 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 693982002903 active site 693982002904 DNA binding site [nucleotide binding] 693982002905 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 693982002906 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693982002907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982002908 active site 693982002909 phosphorylation site [posttranslational modification] 693982002910 intermolecular recognition site; other site 693982002911 dimerization interface [polypeptide binding]; other site 693982002912 response regulator PleD; Reviewed; Region: pleD; PRK09581 693982002913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982002914 active site 693982002915 phosphorylation site [posttranslational modification] 693982002916 intermolecular recognition site; other site 693982002917 dimerization interface [polypeptide binding]; other site 693982002918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982002919 active site 693982002920 phosphorylation site [posttranslational modification] 693982002921 intermolecular recognition site; other site 693982002922 dimerization interface [polypeptide binding]; other site 693982002923 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982002924 metal binding site [ion binding]; metal-binding site 693982002925 active site 693982002926 I-site; other site 693982002927 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 693982002928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982002929 putative substrate translocation pore; other site 693982002930 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693982002931 hypothetical protein; Provisional; Region: PRK05978 693982002932 ribonuclease R; Region: RNase_R; TIGR02063 693982002933 RNB domain; Region: RNB; pfam00773 693982002934 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 693982002935 RNA binding site [nucleotide binding]; other site 693982002936 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 693982002937 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 693982002938 active site 693982002939 interdomain interaction site; other site 693982002940 putative metal-binding site [ion binding]; other site 693982002941 nucleotide binding site [chemical binding]; other site 693982002942 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693982002943 domain I; other site 693982002944 DNA binding groove [nucleotide binding] 693982002945 phosphate binding site [ion binding]; other site 693982002946 domain II; other site 693982002947 domain III; other site 693982002948 nucleotide binding site [chemical binding]; other site 693982002949 catalytic site [active] 693982002950 domain IV; other site 693982002951 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693982002952 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 693982002953 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 693982002954 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 693982002955 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 693982002956 DNA protecting protein DprA; Region: dprA; TIGR00732 693982002957 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 693982002958 dihydroorotase; Validated; Region: PRK09059 693982002959 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 693982002960 active site 693982002961 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 693982002962 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693982002963 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693982002964 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693982002965 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693982002966 active site 693982002967 Predicted permeases [General function prediction only]; Region: COG0679 693982002968 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 693982002969 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 693982002970 metal-dependent hydrolase; Provisional; Region: PRK00685 693982002971 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 693982002972 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 693982002973 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 693982002974 hypothetical protein; Provisional; Region: PRK13687 693982002975 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 693982002976 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 693982002977 GatB domain; Region: GatB_Yqey; smart00845 693982002978 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 693982002979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982002980 Coenzyme A binding pocket [chemical binding]; other site 693982002981 NADH dehydrogenase; Validated; Region: PRK08183 693982002982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 693982002983 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 693982002984 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 693982002985 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693982002986 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 693982002987 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693982002988 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 693982002989 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693982002990 carboxyltransferase (CT) interaction site; other site 693982002991 biotinylation site [posttranslational modification]; other site 693982002992 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 693982002993 Dehydroquinase class II; Region: DHquinase_II; pfam01220 693982002994 trimer interface [polypeptide binding]; other site 693982002995 active site 693982002996 dimer interface [polypeptide binding]; other site 693982002997 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 693982002998 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 693982002999 catalytic residues [active] 693982003000 aspartate aminotransferase; Provisional; Region: PRK05764 693982003001 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982003002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982003003 homodimer interface [polypeptide binding]; other site 693982003004 catalytic residue [active] 693982003005 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 693982003006 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693982003007 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 693982003008 AMIN domain; Region: AMIN; pfam11741 693982003009 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693982003010 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 693982003011 active site 693982003012 metal binding site [ion binding]; metal-binding site 693982003013 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 693982003014 Transglycosylase; Region: Transgly; pfam00912 693982003015 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693982003016 peptide chain release factor 2; Provisional; Region: PRK07342 693982003017 This domain is found in peptide chain release factors; Region: PCRF; smart00937 693982003018 RF-1 domain; Region: RF-1; pfam00472 693982003019 ATP-NAD kinase; Region: NAD_kinase; pfam01513 693982003020 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 693982003021 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 693982003022 dimer interface [polypeptide binding]; other site 693982003023 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982003024 ligand binding site [chemical binding]; other site 693982003025 LysR family transcriptional regulator; Provisional; Region: PRK14997 693982003026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982003027 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 693982003028 putative effector binding pocket; other site 693982003029 putative dimerization interface [polypeptide binding]; other site 693982003030 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 693982003031 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693982003032 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 693982003033 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 693982003034 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693982003035 elongation factor Tu; Reviewed; Region: PRK00049 693982003036 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 693982003037 G1 box; other site 693982003038 GEF interaction site [polypeptide binding]; other site 693982003039 GTP/Mg2+ binding site [chemical binding]; other site 693982003040 Switch I region; other site 693982003041 G2 box; other site 693982003042 G3 box; other site 693982003043 Switch II region; other site 693982003044 G4 box; other site 693982003045 G5 box; other site 693982003046 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 693982003047 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 693982003048 Antibiotic Binding Site [chemical binding]; other site 693982003049 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982003050 extended (e) SDRs; Region: SDR_e; cd08946 693982003051 NAD(P) binding site [chemical binding]; other site 693982003052 active site 693982003053 substrate binding site [chemical binding]; other site 693982003054 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 693982003055 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 693982003056 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 693982003057 putative homodimer interface [polypeptide binding]; other site 693982003058 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 693982003059 heterodimer interface [polypeptide binding]; other site 693982003060 homodimer interface [polypeptide binding]; other site 693982003061 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 693982003062 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 693982003063 23S rRNA interface [nucleotide binding]; other site 693982003064 L7/L12 interface [polypeptide binding]; other site 693982003065 putative thiostrepton binding site; other site 693982003066 L25 interface [polypeptide binding]; other site 693982003067 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 693982003068 mRNA/rRNA interface [nucleotide binding]; other site 693982003069 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 693982003070 23S rRNA interface [nucleotide binding]; other site 693982003071 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 693982003072 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 693982003073 core dimer interface [polypeptide binding]; other site 693982003074 peripheral dimer interface [polypeptide binding]; other site 693982003075 L10 interface [polypeptide binding]; other site 693982003076 L11 interface [polypeptide binding]; other site 693982003077 putative EF-Tu interaction site [polypeptide binding]; other site 693982003078 putative EF-G interaction site [polypeptide binding]; other site 693982003079 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 693982003080 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 693982003081 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 693982003082 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 693982003083 RPB11 interaction site [polypeptide binding]; other site 693982003084 RPB12 interaction site [polypeptide binding]; other site 693982003085 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 693982003086 RPB1 interaction site [polypeptide binding]; other site 693982003087 RPB11 interaction site [polypeptide binding]; other site 693982003088 RPB10 interaction site [polypeptide binding]; other site 693982003089 RPB3 interaction site [polypeptide binding]; other site 693982003090 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 693982003091 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 693982003092 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 693982003093 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 693982003094 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 693982003095 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 693982003096 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 693982003097 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 693982003098 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 693982003099 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 693982003100 DNA binding site [nucleotide binding] 693982003101 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 693982003102 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 693982003103 S17 interaction site [polypeptide binding]; other site 693982003104 S8 interaction site; other site 693982003105 16S rRNA interaction site [nucleotide binding]; other site 693982003106 streptomycin interaction site [chemical binding]; other site 693982003107 23S rRNA interaction site [nucleotide binding]; other site 693982003108 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 693982003109 30S ribosomal protein S7; Validated; Region: PRK05302 693982003110 elongation factor G; Reviewed; Region: PRK00007 693982003111 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 693982003112 G1 box; other site 693982003113 putative GEF interaction site [polypeptide binding]; other site 693982003114 GTP/Mg2+ binding site [chemical binding]; other site 693982003115 Switch I region; other site 693982003116 G2 box; other site 693982003117 G3 box; other site 693982003118 Switch II region; other site 693982003119 G4 box; other site 693982003120 G5 box; other site 693982003121 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 693982003122 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 693982003123 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 693982003124 elongation factor Tu; Reviewed; Region: PRK00049 693982003125 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 693982003126 G1 box; other site 693982003127 GEF interaction site [polypeptide binding]; other site 693982003128 GTP/Mg2+ binding site [chemical binding]; other site 693982003129 Switch I region; other site 693982003130 G2 box; other site 693982003131 G3 box; other site 693982003132 Switch II region; other site 693982003133 G4 box; other site 693982003134 G5 box; other site 693982003135 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 693982003136 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 693982003137 Antibiotic Binding Site [chemical binding]; other site 693982003138 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 693982003139 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 693982003140 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 693982003141 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 693982003142 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 693982003143 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 693982003144 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 693982003145 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 693982003146 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 693982003147 putative translocon binding site; other site 693982003148 protein-rRNA interface [nucleotide binding]; other site 693982003149 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 693982003150 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 693982003151 G-X-X-G motif; other site 693982003152 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 693982003153 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 693982003154 23S rRNA interface [nucleotide binding]; other site 693982003155 5S rRNA interface [nucleotide binding]; other site 693982003156 putative antibiotic binding site [chemical binding]; other site 693982003157 L25 interface [polypeptide binding]; other site 693982003158 L27 interface [polypeptide binding]; other site 693982003159 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 693982003160 23S rRNA interface [nucleotide binding]; other site 693982003161 putative translocon interaction site; other site 693982003162 signal recognition particle (SRP54) interaction site; other site 693982003163 L23 interface [polypeptide binding]; other site 693982003164 trigger factor interaction site; other site 693982003165 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 693982003166 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 693982003167 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 693982003168 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 693982003169 RNA binding site [nucleotide binding]; other site 693982003170 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 693982003171 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 693982003172 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 693982003173 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 693982003174 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 693982003175 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 693982003176 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 693982003177 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 693982003178 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 693982003179 23S rRNA interface [nucleotide binding]; other site 693982003180 L21e interface [polypeptide binding]; other site 693982003181 5S rRNA interface [nucleotide binding]; other site 693982003182 L27 interface [polypeptide binding]; other site 693982003183 L5 interface [polypeptide binding]; other site 693982003184 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 693982003185 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 693982003186 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 693982003187 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 693982003188 23S rRNA binding site [nucleotide binding]; other site 693982003189 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 693982003190 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 693982003191 SecY translocase; Region: SecY; pfam00344 693982003192 adenylate kinase; Reviewed; Region: adk; PRK00279 693982003193 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 693982003194 AMP-binding site [chemical binding]; other site 693982003195 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 693982003196 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 693982003197 30S ribosomal protein S13; Region: bact_S13; TIGR03631 693982003198 30S ribosomal protein S11; Validated; Region: PRK05309 693982003199 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 693982003200 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 693982003201 alphaNTD homodimer interface [polypeptide binding]; other site 693982003202 alphaNTD - beta interaction site [polypeptide binding]; other site 693982003203 alphaNTD - beta' interaction site [polypeptide binding]; other site 693982003204 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 693982003205 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 693982003206 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 693982003207 TMAO/DMSO reductase; Reviewed; Region: PRK05363 693982003208 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 693982003209 Moco binding site; other site 693982003210 metal coordination site [ion binding]; other site 693982003211 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 693982003212 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693982003213 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693982003214 protein binding site [polypeptide binding]; other site 693982003215 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693982003216 protein binding site [polypeptide binding]; other site 693982003217 recombination factor protein RarA; Reviewed; Region: PRK13342 693982003218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982003219 Walker A motif; other site 693982003220 ATP binding site [chemical binding]; other site 693982003221 Walker B motif; other site 693982003222 arginine finger; other site 693982003223 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 693982003224 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 693982003225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693982003226 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693982003227 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693982003228 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 693982003229 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 693982003230 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982003231 motif II; other site 693982003232 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693982003233 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 693982003234 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693982003235 active site 693982003236 camphor resistance protein CrcB; Provisional; Region: PRK14195 693982003237 S-formylglutathione hydrolase; Region: PLN02442 693982003238 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 693982003239 Predicted membrane protein [Function unknown]; Region: COG4291 693982003240 hypothetical protein; Validated; Region: PRK00124 693982003241 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 693982003242 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 693982003243 substrate binding site [chemical binding]; other site 693982003244 catalytic Zn binding site [ion binding]; other site 693982003245 NAD binding site [chemical binding]; other site 693982003246 structural Zn binding site [ion binding]; other site 693982003247 dimer interface [polypeptide binding]; other site 693982003248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982003249 non-specific DNA binding site [nucleotide binding]; other site 693982003250 salt bridge; other site 693982003251 sequence-specific DNA binding site [nucleotide binding]; other site 693982003252 lipoate-protein ligase B; Provisional; Region: PRK14341 693982003253 PrkA family serine protein kinase; Provisional; Region: PRK15455 693982003254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 693982003255 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 693982003256 Uncharacterized conserved protein [Function unknown]; Region: COG2718 693982003257 SpoVR family protein; Provisional; Region: PRK11767 693982003258 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 693982003259 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 693982003260 active site 693982003261 catalytic residues [active] 693982003262 metal binding site [ion binding]; metal-binding site 693982003263 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 693982003264 MgtE intracellular N domain; Region: MgtE_N; smart00924 693982003265 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 693982003266 Divalent cation transporter; Region: MgtE; cl00786 693982003267 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693982003268 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 693982003269 DNA binding residues [nucleotide binding] 693982003270 putative dimer interface [polypeptide binding]; other site 693982003271 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 693982003272 Predicted membrane protein [Function unknown]; Region: COG3503 693982003273 Predicted membrane protein [Function unknown]; Region: COG3821 693982003274 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 693982003275 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 693982003276 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 693982003277 Uncharacterized conserved protein [Function unknown]; Region: COG5458 693982003278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693982003279 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693982003280 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693982003281 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 693982003282 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 693982003283 Sporulation related domain; Region: SPOR; pfam05036 693982003284 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 693982003285 PilZ domain; Region: PilZ; pfam07238 693982003286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 693982003287 PAS domain; Region: PAS_5; pfam07310 693982003288 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 693982003289 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 693982003290 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 693982003291 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 693982003292 nucleophile elbow; other site 693982003293 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 693982003294 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 693982003295 GTP cyclohydrolase I; Provisional; Region: PLN03044 693982003296 active site 693982003297 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 693982003298 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 693982003299 trimerization site [polypeptide binding]; other site 693982003300 active site 693982003301 hypothetical protein; Validated; Region: PRK00041 693982003302 Uncharacterized conserved protein [Function unknown]; Region: COG5502 693982003303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 693982003304 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 693982003305 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 693982003306 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 693982003307 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 693982003308 active site 693982003309 dimer interface [polypeptide binding]; other site 693982003310 motif 1; other site 693982003311 motif 2; other site 693982003312 motif 3; other site 693982003313 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 693982003314 anticodon binding site; other site 693982003315 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 693982003316 putative FMN binding site [chemical binding]; other site 693982003317 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 693982003318 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 693982003319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 693982003320 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 693982003321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982003322 Coenzyme A binding pocket [chemical binding]; other site 693982003323 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 693982003324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982003325 Mg2+ binding site [ion binding]; other site 693982003326 G-X-G motif; other site 693982003327 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 693982003328 anchoring element; other site 693982003329 dimer interface [polypeptide binding]; other site 693982003330 ATP binding site [chemical binding]; other site 693982003331 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 693982003332 active site 693982003333 metal binding site [ion binding]; metal-binding site 693982003334 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 693982003335 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 693982003336 FAD binding domain; Region: FAD_binding_4; pfam01565 693982003337 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693982003338 Uncharacterized conserved protein [Function unknown]; Region: COG2353 693982003339 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 693982003340 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 693982003341 triosephosphate isomerase; Provisional; Region: PRK14565 693982003342 substrate binding site [chemical binding]; other site 693982003343 dimer interface [polypeptide binding]; other site 693982003344 catalytic triad [active] 693982003345 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 693982003346 CTP synthetase; Validated; Region: pyrG; PRK05380 693982003347 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 693982003348 Catalytic site [active] 693982003349 active site 693982003350 UTP binding site [chemical binding]; other site 693982003351 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 693982003352 active site 693982003353 putative oxyanion hole; other site 693982003354 catalytic triad [active] 693982003355 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 693982003356 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 693982003357 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 693982003358 enolase; Provisional; Region: eno; PRK00077 693982003359 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 693982003360 dimer interface [polypeptide binding]; other site 693982003361 metal binding site [ion binding]; metal-binding site 693982003362 substrate binding pocket [chemical binding]; other site 693982003363 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 693982003364 Septum formation initiator; Region: DivIC; pfam04977 693982003365 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 693982003366 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 693982003367 tetramer interface [polypeptide binding]; other site 693982003368 TPP-binding site [chemical binding]; other site 693982003369 heterodimer interface [polypeptide binding]; other site 693982003370 phosphorylation loop region [posttranslational modification] 693982003371 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 693982003372 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693982003373 E3 interaction surface; other site 693982003374 lipoyl attachment site [posttranslational modification]; other site 693982003375 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 693982003376 alpha subunit interface [polypeptide binding]; other site 693982003377 TPP binding site [chemical binding]; other site 693982003378 heterodimer interface [polypeptide binding]; other site 693982003379 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693982003380 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693982003381 E3 interaction surface; other site 693982003382 lipoyl attachment site [posttranslational modification]; other site 693982003383 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 693982003384 e3 binding domain; Region: E3_binding; pfam02817 693982003385 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693982003386 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 693982003387 active site 693982003388 catalytic triad [active] 693982003389 oxyanion hole [active] 693982003390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982003391 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693982003392 Coenzyme A binding pocket [chemical binding]; other site 693982003393 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 693982003394 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 693982003395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982003396 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693982003397 Predicted membrane protein [Function unknown]; Region: COG2261 693982003398 lipoyl synthase; Provisional; Region: PRK05481 693982003399 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693982003400 FeS/SAM binding site; other site 693982003401 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 693982003402 putative coenzyme Q binding site [chemical binding]; other site 693982003403 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 693982003404 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 693982003405 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 693982003406 substrate binding site; other site 693982003407 dimer interface; other site 693982003408 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 693982003409 homotrimer interaction site [polypeptide binding]; other site 693982003410 zinc binding site [ion binding]; other site 693982003411 CDP-binding sites; other site 693982003412 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693982003413 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 693982003414 FMN binding site [chemical binding]; other site 693982003415 active site 693982003416 catalytic residues [active] 693982003417 substrate binding site [chemical binding]; other site 693982003418 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 693982003419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982003420 dimer interface [polypeptide binding]; other site 693982003421 phosphorylation site [posttranslational modification] 693982003422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982003423 ATP binding site [chemical binding]; other site 693982003424 Mg2+ binding site [ion binding]; other site 693982003425 G-X-G motif; other site 693982003426 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 693982003427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982003428 active site 693982003429 phosphorylation site [posttranslational modification] 693982003430 intermolecular recognition site; other site 693982003431 dimerization interface [polypeptide binding]; other site 693982003432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982003433 Walker A motif; other site 693982003434 ATP binding site [chemical binding]; other site 693982003435 Walker B motif; other site 693982003436 arginine finger; other site 693982003437 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 693982003438 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 693982003439 HAMP domain; Region: HAMP; pfam00672 693982003440 dimerization interface [polypeptide binding]; other site 693982003441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982003442 dimer interface [polypeptide binding]; other site 693982003443 phosphorylation site [posttranslational modification] 693982003444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982003445 ATP binding site [chemical binding]; other site 693982003446 Mg2+ binding site [ion binding]; other site 693982003447 G-X-G motif; other site 693982003448 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693982003449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982003450 active site 693982003451 phosphorylation site [posttranslational modification] 693982003452 intermolecular recognition site; other site 693982003453 dimerization interface [polypeptide binding]; other site 693982003454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982003455 Walker A motif; other site 693982003456 ATP binding site [chemical binding]; other site 693982003457 Walker B motif; other site 693982003458 arginine finger; other site 693982003459 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693982003460 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 693982003461 TrkA-N domain; Region: TrkA_N; pfam02254 693982003462 TrkA-C domain; Region: TrkA_C; pfam02080 693982003463 TrkA-N domain; Region: TrkA_N; pfam02254 693982003464 TrkA-C domain; Region: TrkA_C; pfam02080 693982003465 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 693982003466 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 693982003467 homodimer interface [polypeptide binding]; other site 693982003468 substrate-cofactor binding pocket; other site 693982003469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982003470 catalytic residue [active] 693982003471 bacterial Hfq-like; Region: Hfq; cd01716 693982003472 hexamer interface [polypeptide binding]; other site 693982003473 Sm1 motif; other site 693982003474 RNA binding site [nucleotide binding]; other site 693982003475 Sm2 motif; other site 693982003476 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 693982003477 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 693982003478 HflX GTPase family; Region: HflX; cd01878 693982003479 G1 box; other site 693982003480 GTP/Mg2+ binding site [chemical binding]; other site 693982003481 Switch I region; other site 693982003482 G2 box; other site 693982003483 G3 box; other site 693982003484 Switch II region; other site 693982003485 G4 box; other site 693982003486 G5 box; other site 693982003487 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 693982003488 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 693982003489 homodimer interface [polypeptide binding]; other site 693982003490 metal binding site [ion binding]; metal-binding site 693982003491 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 693982003492 homodimer interface [polypeptide binding]; other site 693982003493 active site 693982003494 putative chemical substrate binding site [chemical binding]; other site 693982003495 metal binding site [ion binding]; metal-binding site 693982003496 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 693982003497 nucleoside/Zn binding site; other site 693982003498 dimer interface [polypeptide binding]; other site 693982003499 catalytic motif [active] 693982003500 siroheme synthase; Provisional; Region: cysG; PRK10637 693982003501 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 693982003502 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 693982003503 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 693982003504 active site 693982003505 SAM binding site [chemical binding]; other site 693982003506 homodimer interface [polypeptide binding]; other site 693982003507 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 693982003508 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 693982003509 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693982003510 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693982003511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 693982003512 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 693982003513 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 693982003514 FAD binding pocket [chemical binding]; other site 693982003515 FAD binding motif [chemical binding]; other site 693982003516 phosphate binding motif [ion binding]; other site 693982003517 beta-alpha-beta structure motif; other site 693982003518 NAD binding pocket [chemical binding]; other site 693982003519 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 693982003520 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982003521 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 693982003522 Transposase [DNA replication, recombination, and repair]; Region: COG5433 693982003523 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693982003524 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693982003525 Walker A/P-loop; other site 693982003526 ATP binding site [chemical binding]; other site 693982003527 Q-loop/lid; other site 693982003528 ABC transporter signature motif; other site 693982003529 Walker B; other site 693982003530 D-loop; other site 693982003531 H-loop/switch region; other site 693982003532 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693982003533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982003534 dimer interface [polypeptide binding]; other site 693982003535 conserved gate region; other site 693982003536 putative PBP binding loops; other site 693982003537 ABC-ATPase subunit interface; other site 693982003538 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 693982003539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693982003540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982003541 dimer interface [polypeptide binding]; other site 693982003542 conserved gate region; other site 693982003543 putative PBP binding loops; other site 693982003544 ABC-ATPase subunit interface; other site 693982003545 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 693982003546 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982003547 substrate binding pocket [chemical binding]; other site 693982003548 membrane-bound complex binding site; other site 693982003549 hinge residues; other site 693982003550 cystathionine beta-lyase; Provisional; Region: PRK05967 693982003551 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693982003552 homodimer interface [polypeptide binding]; other site 693982003553 substrate-cofactor binding pocket; other site 693982003554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982003555 catalytic residue [active] 693982003556 salicylate hydroxylase; Provisional; Region: PRK08163 693982003557 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693982003558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 693982003559 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693982003560 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693982003561 serine acetyltransferase; Provisional; Region: cysE; PRK11132 693982003562 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 693982003563 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 693982003564 trimer interface [polypeptide binding]; other site 693982003565 active site 693982003566 substrate binding site [chemical binding]; other site 693982003567 CoA binding site [chemical binding]; other site 693982003568 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 693982003569 Phasin protein; Region: Phasin_2; pfam09361 693982003570 Uncharacterized conserved protein [Function unknown]; Region: COG2127 693982003571 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 693982003572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982003573 Walker A motif; other site 693982003574 ATP binding site [chemical binding]; other site 693982003575 Walker B motif; other site 693982003576 arginine finger; other site 693982003577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982003578 Walker A motif; other site 693982003579 ATP binding site [chemical binding]; other site 693982003580 Walker B motif; other site 693982003581 arginine finger; other site 693982003582 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 693982003583 AzlC protein; Region: AzlC; pfam03591 693982003584 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 693982003585 HIT family signature motif; other site 693982003586 catalytic residue [active] 693982003587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 693982003588 Protein of unknown function, DUF482; Region: DUF482; pfam04339 693982003589 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 693982003590 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 693982003591 putative active site [active] 693982003592 catalytic site [active] 693982003593 putative metal binding site [ion binding]; other site 693982003594 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 693982003595 homotrimer interaction site [polypeptide binding]; other site 693982003596 putative active site [active] 693982003597 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 693982003598 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 693982003599 rRNA interaction site [nucleotide binding]; other site 693982003600 S8 interaction site; other site 693982003601 putative laminin-1 binding site; other site 693982003602 elongation factor Ts; Provisional; Region: tsf; PRK09377 693982003603 UBA/TS-N domain; Region: UBA; pfam00627 693982003604 Elongation factor TS; Region: EF_TS; pfam00889 693982003605 Elongation factor TS; Region: EF_TS; pfam00889 693982003606 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 693982003607 putative nucleotide binding site [chemical binding]; other site 693982003608 uridine monophosphate binding site [chemical binding]; other site 693982003609 homohexameric interface [polypeptide binding]; other site 693982003610 ribosome recycling factor; Reviewed; Region: frr; PRK00083 693982003611 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 693982003612 hinge region; other site 693982003613 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 693982003614 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 693982003615 catalytic residue [active] 693982003616 putative FPP diphosphate binding site; other site 693982003617 putative FPP binding hydrophobic cleft; other site 693982003618 dimer interface [polypeptide binding]; other site 693982003619 putative IPP diphosphate binding site; other site 693982003620 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 693982003621 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 693982003622 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 693982003623 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 693982003624 active site 693982003625 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 693982003626 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 693982003627 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 693982003628 putative substrate binding region [chemical binding]; other site 693982003629 putative substrate binding region [chemical binding]; other site 693982003630 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 693982003631 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693982003632 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693982003633 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693982003634 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693982003635 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693982003636 Surface antigen; Region: Bac_surface_Ag; pfam01103 693982003637 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 693982003638 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 693982003639 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 693982003640 trimer interface [polypeptide binding]; other site 693982003641 active site 693982003642 UDP-GlcNAc binding site [chemical binding]; other site 693982003643 lipid binding site [chemical binding]; lipid-binding site 693982003644 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 693982003645 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 693982003646 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 693982003647 active site 693982003648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 693982003649 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 693982003650 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 693982003651 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 693982003652 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 693982003653 dimer interface [polypeptide binding]; other site 693982003654 active site 693982003655 citrylCoA binding site [chemical binding]; other site 693982003656 NADH binding [chemical binding]; other site 693982003657 cationic pore residues; other site 693982003658 oxalacetate/citrate binding site [chemical binding]; other site 693982003659 coenzyme A binding site [chemical binding]; other site 693982003660 catalytic triad [active] 693982003661 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 693982003662 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 693982003663 Competence protein; Region: Competence; pfam03772 693982003664 tonB-system energizer ExbB; Region: exbB; TIGR02797 693982003665 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 693982003666 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 693982003667 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 693982003668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693982003669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982003670 S-adenosylmethionine binding site [chemical binding]; other site 693982003671 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 693982003672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 693982003673 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 693982003674 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 693982003675 HIGH motif; other site 693982003676 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 693982003677 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 693982003678 active site 693982003679 KMSKS motif; other site 693982003680 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 693982003681 tRNA binding surface [nucleotide binding]; other site 693982003682 anticodon binding site; other site 693982003683 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 693982003684 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 693982003685 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693982003686 Sel1-like repeats; Region: SEL1; smart00671 693982003687 Sel1-like repeats; Region: SEL1; smart00671 693982003688 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 693982003689 putative catalytic site [active] 693982003690 putative phosphate binding site [ion binding]; other site 693982003691 active site 693982003692 metal binding site A [ion binding]; metal-binding site 693982003693 DNA binding site [nucleotide binding] 693982003694 putative AP binding site [nucleotide binding]; other site 693982003695 putative metal binding site B [ion binding]; other site 693982003696 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 693982003697 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 693982003698 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 693982003699 putative active site [active] 693982003700 catalytic site [active] 693982003701 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 693982003702 putative active site [active] 693982003703 catalytic site [active] 693982003704 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 693982003705 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 693982003706 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693982003707 Zn2+ binding site [ion binding]; other site 693982003708 Mg2+ binding site [ion binding]; other site 693982003709 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 693982003710 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 693982003711 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 693982003712 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 693982003713 active site 693982003714 HIGH motif; other site 693982003715 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693982003716 KMSK motif region; other site 693982003717 tRNA binding surface [nucleotide binding]; other site 693982003718 DALR anticodon binding domain; Region: DALR_1; smart00836 693982003719 anticodon binding site; other site 693982003720 Sporulation related domain; Region: SPOR; pfam05036 693982003721 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 693982003722 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 693982003723 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 693982003724 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 693982003725 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693982003726 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 693982003727 Walker A/P-loop; other site 693982003728 ATP binding site [chemical binding]; other site 693982003729 Q-loop/lid; other site 693982003730 ABC transporter signature motif; other site 693982003731 Walker B; other site 693982003732 D-loop; other site 693982003733 H-loop/switch region; other site 693982003734 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 693982003735 sec-independent translocase; Provisional; Region: PRK00708 693982003736 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 693982003737 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 693982003738 seryl-tRNA synthetase; Provisional; Region: PRK05431 693982003739 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 693982003740 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 693982003741 dimer interface [polypeptide binding]; other site 693982003742 active site 693982003743 motif 1; other site 693982003744 motif 2; other site 693982003745 motif 3; other site 693982003746 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 693982003747 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 693982003748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982003749 S-adenosylmethionine binding site [chemical binding]; other site 693982003750 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 693982003751 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693982003752 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693982003753 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693982003754 Peptidase family M23; Region: Peptidase_M23; pfam01551 693982003755 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 693982003756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982003757 Walker A motif; other site 693982003758 ATP binding site [chemical binding]; other site 693982003759 Walker B motif; other site 693982003760 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 693982003761 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 693982003762 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 693982003763 Protein export membrane protein; Region: SecD_SecF; cl14618 693982003764 Protein export membrane protein; Region: SecD_SecF; pfam02355 693982003765 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 693982003766 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 693982003767 substrate binding pocket [chemical binding]; other site 693982003768 aspartate-rich region 1; other site 693982003769 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 693982003770 Glucose inhibited division protein A; Region: GIDA; pfam01134 693982003771 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 693982003772 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 693982003773 trigger factor; Provisional; Region: tig; PRK01490 693982003774 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693982003775 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 693982003776 glycine dehydrogenase; Provisional; Region: PRK05367 693982003777 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 693982003778 tetramer interface [polypeptide binding]; other site 693982003779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982003780 catalytic residue [active] 693982003781 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 693982003782 tetramer interface [polypeptide binding]; other site 693982003783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982003784 catalytic residue [active] 693982003785 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 693982003786 lipoyl attachment site [posttranslational modification]; other site 693982003787 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 693982003788 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693982003789 integrase; Provisional; Region: PRK09692 693982003790 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 693982003791 active site 693982003792 Int/Topo IB signature motif; other site 693982003793 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 693982003794 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 693982003795 gpW; Region: gpW; pfam02831 693982003796 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 693982003797 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 693982003798 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 693982003799 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 693982003800 tandem repeat interface [polypeptide binding]; other site 693982003801 oligomer interface [polypeptide binding]; other site 693982003802 active site residues [active] 693982003803 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 693982003804 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 693982003805 cell surface protein SprA; Region: surface_SprA; TIGR04189 693982003806 tape measure domain; Region: tape_meas_nterm; TIGR02675 693982003807 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 693982003808 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 693982003809 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 693982003810 Putative phage tail protein; Region: Phage-tail_3; pfam13550 693982003811 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 693982003812 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982003813 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693982003814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982003815 S-adenosylmethionine binding site [chemical binding]; other site 693982003816 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 693982003817 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 693982003818 Ligand binding site; other site 693982003819 metal-binding site 693982003820 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 693982003821 HNH endonuclease; Region: HNH_3; pfam13392 693982003822 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 693982003823 DNA-binding interface [nucleotide binding]; DNA binding site 693982003824 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 693982003825 Phosphopantetheine attachment site; Region: PP-binding; cl09936 693982003826 dephospho-CoA kinase; Region: PLN02422 693982003827 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 693982003828 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982003829 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982003830 DNA binding site [nucleotide binding] 693982003831 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 693982003832 Protein of unknown function (DUF550); Region: DUF550; pfam04447 693982003833 GcrA cell cycle regulator; Region: GcrA; cl11564 693982003834 GcrA cell cycle regulator; Region: GcrA; cl11564 693982003835 NosL; Region: NosL; cl01769 693982003836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982003837 S-adenosylmethionine binding site [chemical binding]; other site 693982003838 dihydroorotase; Validated; Region: PRK09059 693982003839 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 693982003840 polymerase nucleotide-binding site; other site 693982003841 DNA-binding residues [nucleotide binding]; DNA binding site 693982003842 nucleotide binding site [chemical binding]; other site 693982003843 primase nucleotide-binding site [nucleotide binding]; other site 693982003844 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 693982003845 NUMOD4 motif; Region: NUMOD4; pfam07463 693982003846 HNH endonuclease; Region: HNH_3; pfam13392 693982003847 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 693982003848 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 693982003849 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 693982003850 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 693982003851 active site 693982003852 metal-binding site 693982003853 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 693982003854 active site 693982003855 Zn binding site [ion binding]; other site 693982003856 VRR-NUC domain; Region: VRR_NUC; pfam08774 693982003857 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 693982003858 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693982003859 ATP binding site [chemical binding]; other site 693982003860 putative Mg++ binding site [ion binding]; other site 693982003861 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 693982003862 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 693982003863 CRISPR-associated protein, Csx11 family; Region: cas_csx11; TIGR02682 693982003864 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693982003865 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982003866 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 693982003867 N-terminal domain interface [polypeptide binding]; other site 693982003868 dimer interface [polypeptide binding]; other site 693982003869 substrate binding pocket (H-site) [chemical binding]; other site 693982003870 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 693982003871 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 693982003872 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 693982003873 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 693982003874 active site 693982003875 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 693982003876 TSCPD domain; Region: TSCPD; pfam12637 693982003877 Uncharacterized conserved protein [Function unknown]; Region: COG1801 693982003878 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 693982003879 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693982003880 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693982003881 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 693982003882 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693982003883 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693982003884 dimer interface [polypeptide binding]; other site 693982003885 ssDNA binding site [nucleotide binding]; other site 693982003886 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693982003887 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 693982003888 DNA gyrase subunit A; Validated; Region: PRK05560 693982003889 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 693982003890 CAP-like domain; other site 693982003891 active site 693982003892 primary dimer interface [polypeptide binding]; other site 693982003893 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693982003894 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693982003895 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693982003896 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693982003897 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693982003898 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 693982003899 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693982003900 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693982003901 catalytic residue [active] 693982003902 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 693982003903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982003904 Coenzyme A binding pocket [chemical binding]; other site 693982003905 Streptomycin 6-kinase [Defense mechanisms]; Region: StrB; COG3570 693982003906 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693982003907 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 693982003908 FMN binding site [chemical binding]; other site 693982003909 active site 693982003910 substrate binding site [chemical binding]; other site 693982003911 catalytic residue [active] 693982003912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982003913 dimerization interface [polypeptide binding]; other site 693982003914 putative DNA binding site [nucleotide binding]; other site 693982003915 putative Zn2+ binding site [ion binding]; other site 693982003916 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982003917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982003918 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693982003919 putative effector binding pocket; other site 693982003920 dimerization interface [polypeptide binding]; other site 693982003921 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 693982003922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693982003923 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982003924 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982003925 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982003926 putative DNA binding site [nucleotide binding]; other site 693982003927 putative Zn2+ binding site [ion binding]; other site 693982003928 AsnC family; Region: AsnC_trans_reg; pfam01037 693982003929 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 693982003930 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693982003931 putative metal binding site; other site 693982003932 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982003933 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 693982003934 putative ADP-binding pocket [chemical binding]; other site 693982003935 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982003936 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 693982003937 putative ADP-binding pocket [chemical binding]; other site 693982003938 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 693982003939 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982003940 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 693982003941 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693982003942 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693982003943 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 693982003944 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693982003945 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693982003946 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 693982003947 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693982003948 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693982003949 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 693982003950 IMP binding site; other site 693982003951 dimer interface [polypeptide binding]; other site 693982003952 partial ornithine binding site; other site 693982003953 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693982003954 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 693982003955 putative NAD(P) binding site [chemical binding]; other site 693982003956 catalytic Zn binding site [ion binding]; other site 693982003957 Predicted metalloprotease [General function prediction only]; Region: COG2321 693982003958 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 693982003959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982003960 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693982003961 putative substrate translocation pore; other site 693982003962 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 693982003963 putative efflux protein, MATE family; Region: matE; TIGR00797 693982003964 cation binding site [ion binding]; other site 693982003965 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 693982003966 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 693982003967 active site 693982003968 (T/H)XGH motif; other site 693982003969 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 693982003970 active site 693982003971 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 693982003972 active site 693982003973 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 693982003974 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 693982003975 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 693982003976 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 693982003977 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 693982003978 classical (c) SDRs; Region: SDR_c; cd05233 693982003979 NAD(P) binding site [chemical binding]; other site 693982003980 active site 693982003981 SEC-C motif; Region: SEC-C; pfam02810 693982003982 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693982003983 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 693982003984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 693982003985 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693982003986 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693982003987 classical (c) SDRs; Region: SDR_c; cd05233 693982003988 NAD(P) binding site [chemical binding]; other site 693982003989 active site 693982003990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693982003991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982003992 putative substrate translocation pore; other site 693982003993 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 693982003994 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982003995 DNA binding site [nucleotide binding] 693982003996 Predicted integral membrane protein [Function unknown]; Region: COG5616 693982003997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982003998 TPR motif; other site 693982003999 binding surface 693982004000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982004001 TPR motif; other site 693982004002 binding surface 693982004003 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693982004004 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 693982004005 putative hydrolase; Provisional; Region: PRK02113 693982004006 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 693982004007 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693982004008 active site 693982004009 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 693982004010 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 693982004011 active site 693982004012 HIGH motif; other site 693982004013 KMSKS motif; other site 693982004014 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 693982004015 tRNA binding surface [nucleotide binding]; other site 693982004016 anticodon binding site; other site 693982004017 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538 693982004018 metal binding site [ion binding]; metal-binding site 693982004019 DNA polymerase III subunit delta'; Validated; Region: PRK09112 693982004020 AAA ATPase domain; Region: AAA_16; pfam13191 693982004021 DNA polymerase III subunit delta'; Validated; Region: PRK08485 693982004022 Peptidase family M23; Region: Peptidase_M23; pfam01551 693982004023 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 693982004024 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 693982004025 TMP-binding site; other site 693982004026 ATP-binding site [chemical binding]; other site 693982004027 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 693982004028 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 693982004029 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 693982004030 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 693982004031 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 693982004032 Uncharacterized conserved protein [Function unknown]; Region: COG5361 693982004033 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 693982004034 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 693982004035 Uncharacterized conserved protein [Function unknown]; Region: COG5361 693982004036 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 693982004037 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 693982004038 LexA repressor; Validated; Region: PRK00215 693982004039 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 693982004040 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693982004041 Catalytic site [active] 693982004042 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 693982004043 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 693982004044 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 693982004045 putative active site [active] 693982004046 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 693982004047 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 693982004048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982004049 short chain dehydrogenase; Provisional; Region: PRK06101 693982004050 NAD(P) binding site [chemical binding]; other site 693982004051 active site 693982004052 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 693982004053 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 693982004054 dimer interface [polypeptide binding]; other site 693982004055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982004056 catalytic residue [active] 693982004057 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 693982004058 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 693982004059 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 693982004060 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 693982004061 active site residue [active] 693982004062 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 693982004063 active site residue [active] 693982004064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693982004065 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 693982004066 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 693982004067 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 693982004068 hexamer interface [polypeptide binding]; other site 693982004069 ligand binding site [chemical binding]; other site 693982004070 putative active site [active] 693982004071 NAD(P) binding site [chemical binding]; other site 693982004072 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982004073 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982004074 putative DNA binding site [nucleotide binding]; other site 693982004075 putative Zn2+ binding site [ion binding]; other site 693982004076 AsnC family; Region: AsnC_trans_reg; pfam01037 693982004077 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 693982004078 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 693982004079 active site 693982004080 metal binding site [ion binding]; metal-binding site 693982004081 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693982004082 Uncharacterized conserved protein [Function unknown]; Region: COG5453 693982004083 threonine dehydratase; Validated; Region: PRK08639 693982004084 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 693982004085 tetramer interface [polypeptide binding]; other site 693982004086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982004087 catalytic residue [active] 693982004088 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693982004089 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 693982004090 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 693982004091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 693982004092 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 693982004093 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693982004094 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 693982004095 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 693982004096 putative MPT binding site; other site 693982004097 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693982004098 active site 693982004099 Uncharacterized conserved protein [Function unknown]; Region: COG0062 693982004100 putative carbohydrate kinase; Provisional; Region: PRK10565 693982004101 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 693982004102 putative substrate binding site [chemical binding]; other site 693982004103 putative ATP binding site [chemical binding]; other site 693982004104 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 693982004105 Nitrogen regulatory protein P-II; Region: P-II; smart00938 693982004106 glutamine synthetase; Provisional; Region: glnA; PRK09469 693982004107 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 693982004108 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693982004109 Uncharacterized conserved protein [Function unknown]; Region: COG3785 693982004110 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 693982004111 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 693982004112 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 693982004113 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 693982004114 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 693982004115 catalytic residues [active] 693982004116 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 693982004117 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693982004118 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982004119 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 693982004120 Sulfatase; Region: Sulfatase; pfam00884 693982004121 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 693982004122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 693982004123 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 693982004124 putative catalytic site [active] 693982004125 putative phosphate binding site [ion binding]; other site 693982004126 active site 693982004127 metal binding site A [ion binding]; metal-binding site 693982004128 DNA binding site [nucleotide binding] 693982004129 putative AP binding site [nucleotide binding]; other site 693982004130 putative metal binding site B [ion binding]; other site 693982004131 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 693982004132 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 693982004133 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693982004134 ATP binding site [chemical binding]; other site 693982004135 putative Mg++ binding site [ion binding]; other site 693982004136 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693982004137 nucleotide binding region [chemical binding]; other site 693982004138 ATP-binding site [chemical binding]; other site 693982004139 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 693982004140 Uncharacterized conserved protein [Function unknown]; Region: COG2938 693982004141 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 693982004142 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 693982004143 generic binding surface II; other site 693982004144 ssDNA binding site; other site 693982004145 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693982004146 ATP binding site [chemical binding]; other site 693982004147 putative Mg++ binding site [ion binding]; other site 693982004148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693982004149 nucleotide binding region [chemical binding]; other site 693982004150 ATP-binding site [chemical binding]; other site 693982004151 Uncharacterized conserved protein [Function unknown]; Region: COG2928 693982004152 putative acetyltransferase; Provisional; Region: PRK03624 693982004153 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982004154 Coenzyme A binding pocket [chemical binding]; other site 693982004155 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 693982004156 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 693982004157 glutaminase active site [active] 693982004158 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 693982004159 dimer interface [polypeptide binding]; other site 693982004160 active site 693982004161 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 693982004162 dimer interface [polypeptide binding]; other site 693982004163 active site 693982004164 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 693982004165 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 693982004166 Substrate binding site; other site 693982004167 Mg++ binding site; other site 693982004168 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 693982004169 active site 693982004170 substrate binding site [chemical binding]; other site 693982004171 CoA binding site [chemical binding]; other site 693982004172 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 693982004173 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 693982004174 PhoU domain; Region: PhoU; pfam01895 693982004175 PhoU domain; Region: PhoU; pfam01895 693982004176 SurA N-terminal domain; Region: SurA_N_3; cl07813 693982004177 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 693982004178 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 693982004179 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 693982004180 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693982004181 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 693982004182 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 693982004183 active site 693982004184 ribulose/triose binding site [chemical binding]; other site 693982004185 phosphate binding site [ion binding]; other site 693982004186 substrate (anthranilate) binding pocket [chemical binding]; other site 693982004187 product (indole) binding pocket [chemical binding]; other site 693982004188 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 693982004189 trimer interface [polypeptide binding]; other site 693982004190 dimer interface [polypeptide binding]; other site 693982004191 putative active site [active] 693982004192 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 693982004193 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 693982004194 dimer interface [polypeptide binding]; other site 693982004195 putative functional site; other site 693982004196 putative MPT binding site; other site 693982004197 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 693982004198 Domain of unknown function DUF21; Region: DUF21; pfam01595 693982004199 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693982004200 Transporter associated domain; Region: CorC_HlyC; smart01091 693982004201 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982004202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982004203 DNA-binding site [nucleotide binding]; DNA binding site 693982004204 FCD domain; Region: FCD; pfam07729 693982004205 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 693982004206 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 693982004207 putative ligand binding site [chemical binding]; other site 693982004208 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982004209 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693982004210 TM-ABC transporter signature motif; other site 693982004211 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982004212 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693982004213 TM-ABC transporter signature motif; other site 693982004214 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 693982004215 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982004216 Walker A/P-loop; other site 693982004217 ATP binding site [chemical binding]; other site 693982004218 Q-loop/lid; other site 693982004219 ABC transporter signature motif; other site 693982004220 Walker B; other site 693982004221 D-loop; other site 693982004222 H-loop/switch region; other site 693982004223 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982004224 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 693982004225 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 693982004226 NADP binding site [chemical binding]; other site 693982004227 dimer interface [polypeptide binding]; other site 693982004228 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 693982004229 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 693982004230 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 693982004231 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693982004232 Predicted permeases [General function prediction only]; Region: COG0679 693982004233 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 693982004234 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 693982004235 peptide chain release factor 1; Provisional; Region: PRK04011 693982004236 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 693982004237 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 693982004238 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 693982004239 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 693982004240 conserved cys residue [active] 693982004241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982004242 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 693982004243 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cl00720 693982004244 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693982004245 classical (c) SDRs; Region: SDR_c; cd05233 693982004246 NAD(P) binding site [chemical binding]; other site 693982004247 active site 693982004248 acyl-CoA synthetase; Validated; Region: PRK07470 693982004249 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693982004250 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 693982004251 acyl-activating enzyme (AAE) consensus motif; other site 693982004252 acyl-activating enzyme (AAE) consensus motif; other site 693982004253 putative AMP binding site [chemical binding]; other site 693982004254 putative active site [active] 693982004255 putative CoA binding site [chemical binding]; other site 693982004256 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 693982004257 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 693982004258 active site 693982004259 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693982004260 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 693982004261 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693982004262 classical (c) SDRs; Region: SDR_c; cd05233 693982004263 NAD(P) binding site [chemical binding]; other site 693982004264 active site 693982004265 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693982004266 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 693982004267 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693982004268 DctM-like transporters; Region: DctM; pfam06808 693982004269 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693982004270 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693982004271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982004272 NAD(P) binding site [chemical binding]; other site 693982004273 active site 693982004274 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 693982004275 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693982004276 PYR/PP interface [polypeptide binding]; other site 693982004277 dimer interface [polypeptide binding]; other site 693982004278 TPP binding site [chemical binding]; other site 693982004279 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693982004280 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 693982004281 TPP-binding site [chemical binding]; other site 693982004282 dimer interface [polypeptide binding]; other site 693982004283 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693982004284 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 693982004285 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693982004286 DctM-like transporters; Region: DctM; pfam06808 693982004287 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693982004288 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 693982004289 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693982004290 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693982004291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982004292 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693982004293 dimerization interface [polypeptide binding]; other site 693982004294 substrate binding pocket [chemical binding]; other site 693982004295 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693982004296 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 693982004297 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693982004298 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693982004299 catalytic residue [active] 693982004300 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982004301 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982004302 putative DNA binding site [nucleotide binding]; other site 693982004303 putative Zn2+ binding site [ion binding]; other site 693982004304 AsnC family; Region: AsnC_trans_reg; pfam01037 693982004305 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 693982004306 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 693982004307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 693982004308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982004309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982004310 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 693982004311 substrate binding pocket [chemical binding]; other site 693982004312 dimerization interface [polypeptide binding]; other site 693982004313 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 693982004314 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 693982004315 Uncharacterized conserved protein [Function unknown]; Region: COG1430 693982004316 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693982004317 DNA-binding site [nucleotide binding]; DNA binding site 693982004318 RNA-binding motif; other site 693982004319 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693982004320 DNA-binding site [nucleotide binding]; DNA binding site 693982004321 RNA-binding motif; other site 693982004322 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982004323 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 693982004324 dimer interface [polypeptide binding]; other site 693982004325 active site 693982004326 metal binding site [ion binding]; metal-binding site 693982004327 glutathione binding site [chemical binding]; other site 693982004328 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 693982004329 DHH family; Region: DHH; pfam01368 693982004330 DHHA1 domain; Region: DHHA1; pfam02272 693982004331 homoserine dehydrogenase; Provisional; Region: PRK06349 693982004332 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 693982004333 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 693982004334 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 693982004335 aminotransferase; Validated; Region: PRK09148 693982004336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982004337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982004338 homodimer interface [polypeptide binding]; other site 693982004339 catalytic residue [active] 693982004340 Short C-terminal domain; Region: SHOCT; pfam09851 693982004341 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 693982004342 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 693982004343 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 693982004344 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 693982004345 active site 693982004346 hypothetical protein; Reviewed; Region: PRK00024 693982004347 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 693982004348 MPN+ (JAMM) motif; other site 693982004349 Zinc-binding site [ion binding]; other site 693982004350 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 693982004351 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 693982004352 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693982004353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982004354 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693982004355 FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997 693982004356 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 693982004357 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 693982004358 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 693982004359 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693982004360 catalytic residue [active] 693982004361 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 693982004362 FeS assembly protein SufD; Region: sufD; TIGR01981 693982004363 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 693982004364 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 693982004365 Walker A/P-loop; other site 693982004366 ATP binding site [chemical binding]; other site 693982004367 Q-loop/lid; other site 693982004368 ABC transporter signature motif; other site 693982004369 Walker B; other site 693982004370 D-loop; other site 693982004371 H-loop/switch region; other site 693982004372 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 693982004373 putative ABC transporter; Region: ycf24; CHL00085 693982004374 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 693982004375 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 693982004376 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693982004377 catalytic residue [active] 693982004378 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 693982004379 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377 693982004380 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 693982004381 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 693982004382 active site 693982004383 HIGH motif; other site 693982004384 dimer interface [polypeptide binding]; other site 693982004385 KMSKS motif; other site 693982004386 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693982004387 RNA binding surface [nucleotide binding]; other site 693982004388 Protein of unknown function; Region: DUF3971; pfam13116 693982004389 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 693982004390 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693982004391 catalytic triad [active] 693982004392 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 693982004393 dinuclear metal binding motif [ion binding]; other site 693982004394 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693982004395 Peptidase family M23; Region: Peptidase_M23; pfam01551 693982004396 helicase 45; Provisional; Region: PTZ00424 693982004397 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693982004398 ATP binding site [chemical binding]; other site 693982004399 Mg++ binding site [ion binding]; other site 693982004400 motif III; other site 693982004401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693982004402 nucleotide binding region [chemical binding]; other site 693982004403 ATP-binding site [chemical binding]; other site 693982004404 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_20; cd04679 693982004405 nudix motif; other site 693982004406 TfoX N-terminal domain; Region: TfoX_N; pfam04993 693982004407 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 693982004408 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 693982004409 putative MPT binding site; other site 693982004410 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 693982004411 Ligand binding site; other site 693982004412 metal-binding site 693982004413 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 693982004414 XdhC Rossmann domain; Region: XdhC_C; pfam13478 693982004415 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 693982004416 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 693982004417 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 693982004418 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 693982004419 metal ion-dependent adhesion site (MIDAS); other site 693982004420 MoxR-like ATPases [General function prediction only]; Region: COG0714 693982004421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982004422 Walker A motif; other site 693982004423 ATP binding site [chemical binding]; other site 693982004424 Walker B motif; other site 693982004425 arginine finger; other site 693982004426 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 693982004427 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 693982004428 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 693982004429 ligand binding site [chemical binding]; other site 693982004430 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 693982004431 putative active site pocket [active] 693982004432 cleavage site 693982004433 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 693982004434 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 693982004435 substrate binding site [chemical binding]; other site 693982004436 hexamer interface [polypeptide binding]; other site 693982004437 metal binding site [ion binding]; metal-binding site 693982004438 Predicted secreted protein [Function unknown]; Region: COG5497 693982004439 DZF domain; Region: DZF; cl02675 693982004440 adenylosuccinate lyase; Provisional; Region: PRK07492 693982004441 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 693982004442 tetramer interface [polypeptide binding]; other site 693982004443 active site 693982004444 PilZ domain; Region: PilZ; cl01260 693982004445 Predicted integral membrane protein [Function unknown]; Region: COG5473 693982004446 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 693982004447 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693982004448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982004449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982004450 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 693982004451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982004452 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982004453 dimerization interface [polypeptide binding]; other site 693982004454 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 693982004455 hypothetical protein; Provisional; Region: PRK09262 693982004456 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 693982004457 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 693982004458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 693982004459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 693982004460 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 693982004461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 693982004462 Uncharacterized conserved protein [Function unknown]; Region: COG5467 693982004463 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 693982004464 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 693982004465 ATP binding site [chemical binding]; other site 693982004466 active site 693982004467 substrate binding site [chemical binding]; other site 693982004468 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 693982004469 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 693982004470 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 693982004471 putative active site [active] 693982004472 catalytic triad [active] 693982004473 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 693982004474 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693982004475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982004476 DNA-binding site [nucleotide binding]; DNA binding site 693982004477 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982004478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982004479 homodimer interface [polypeptide binding]; other site 693982004480 catalytic residue [active] 693982004481 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 693982004482 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 693982004483 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 693982004484 dimerization interface [polypeptide binding]; other site 693982004485 ATP binding site [chemical binding]; other site 693982004486 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 693982004487 dimerization interface [polypeptide binding]; other site 693982004488 ATP binding site [chemical binding]; other site 693982004489 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 693982004490 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 693982004491 putative GSH binding site [chemical binding]; other site 693982004492 catalytic residues [active] 693982004493 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 693982004494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982004495 putative substrate translocation pore; other site 693982004496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982004497 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 693982004498 putative substrate translocation pore; other site 693982004499 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 693982004500 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693982004501 active site 693982004502 putative lithium-binding site [ion binding]; other site 693982004503 substrate binding site [chemical binding]; other site 693982004504 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 693982004505 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 693982004506 Ligand Binding Site [chemical binding]; other site 693982004507 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 693982004508 glutaminase; Provisional; Region: PRK00971 693982004509 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 693982004510 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 693982004511 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693982004512 RNA binding surface [nucleotide binding]; other site 693982004513 Domain of unknown function DUF87; Region: DUF87; pfam01935 693982004514 HerA helicase [Replication, recombination, and repair]; Region: COG0433 693982004515 glutamate racemase; Provisional; Region: PRK00865 693982004516 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 693982004517 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 693982004518 isocitrate dehydrogenase; Validated; Region: PRK08299 693982004519 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 693982004520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982004521 Protein involved in beta-1,3-glucan synthesis [Carbohydrate transport and metabolism]; Region: SMI1; COG4282 693982004522 Uncharacterized conserved protein [Function unknown]; Region: COG5361 693982004523 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 693982004524 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 693982004525 Uncharacterized conserved protein [Function unknown]; Region: COG5361 693982004526 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 693982004527 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 693982004528 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 693982004529 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693982004530 Sulfate transporter family; Region: Sulfate_transp; pfam00916 693982004531 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 693982004532 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 693982004533 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 693982004534 motif 1; other site 693982004535 active site 693982004536 motif 2; other site 693982004537 motif 3; other site 693982004538 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 693982004539 recombinase A; Provisional; Region: recA; PRK09354 693982004540 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 693982004541 hexamer interface [polypeptide binding]; other site 693982004542 Walker A motif; other site 693982004543 ATP binding site [chemical binding]; other site 693982004544 Walker B motif; other site 693982004545 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693982004546 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 693982004547 substrate binding site [chemical binding]; other site 693982004548 ATP binding site [chemical binding]; other site 693982004549 Uncharacterized enzyme involved in pigment biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IndA; COG2313 693982004550 PAS domain; Region: PAS; smart00091 693982004551 PAS domain; Region: PAS_9; pfam13426 693982004552 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693982004553 PAS domain; Region: PAS; smart00091 693982004554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982004555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982004556 dimer interface [polypeptide binding]; other site 693982004557 phosphorylation site [posttranslational modification] 693982004558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982004559 ATP binding site [chemical binding]; other site 693982004560 Mg2+ binding site [ion binding]; other site 693982004561 G-X-G motif; other site 693982004562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982004563 Response regulator receiver domain; Region: Response_reg; pfam00072 693982004564 active site 693982004565 phosphorylation site [posttranslational modification] 693982004566 intermolecular recognition site; other site 693982004567 dimerization interface [polypeptide binding]; other site 693982004568 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 693982004569 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693982004570 catalytic core [active] 693982004571 Predicted ATPase [General function prediction only]; Region: COG3106 693982004572 Predicted membrane protein [Function unknown]; Region: COG3768 693982004573 Domain of unknown function (DUF697); Region: DUF697; cl12064 693982004574 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 693982004575 catalytic center binding site [active] 693982004576 ATP binding site [chemical binding]; other site 693982004577 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 693982004578 homooctamer interface [polypeptide binding]; other site 693982004579 active site 693982004580 dihydropteroate synthase; Region: DHPS; TIGR01496 693982004581 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 693982004582 substrate binding pocket [chemical binding]; other site 693982004583 dimer interface [polypeptide binding]; other site 693982004584 inhibitor binding site; inhibition site 693982004585 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661 693982004586 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 693982004587 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982004588 catalytic loop [active] 693982004589 iron binding site [ion binding]; other site 693982004590 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 693982004591 cytochrome b; Provisional; Region: CYTB; MTH00191 693982004592 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 693982004593 Qi binding site; other site 693982004594 intrachain domain interface; other site 693982004595 interchain domain interface [polypeptide binding]; other site 693982004596 heme bH binding site [chemical binding]; other site 693982004597 heme bL binding site [chemical binding]; other site 693982004598 Qo binding site; other site 693982004599 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 693982004600 interchain domain interface [polypeptide binding]; other site 693982004601 intrachain domain interface; other site 693982004602 Qi binding site; other site 693982004603 Qo binding site; other site 693982004604 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 693982004605 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 693982004606 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 693982004607 [2Fe-2S] cluster binding site [ion binding]; other site 693982004608 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693982004609 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693982004610 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 693982004611 Walker A/P-loop; other site 693982004612 ATP binding site [chemical binding]; other site 693982004613 Q-loop/lid; other site 693982004614 ABC transporter signature motif; other site 693982004615 Walker B; other site 693982004616 D-loop; other site 693982004617 H-loop/switch region; other site 693982004618 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693982004619 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693982004620 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982004621 Walker A/P-loop; other site 693982004622 ATP binding site [chemical binding]; other site 693982004623 Q-loop/lid; other site 693982004624 ABC transporter signature motif; other site 693982004625 Walker B; other site 693982004626 D-loop; other site 693982004627 H-loop/switch region; other site 693982004628 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 693982004629 Predicted flavoprotein [General function prediction only]; Region: COG0431 693982004630 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693982004631 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 693982004632 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 693982004633 DNA binding residues [nucleotide binding] 693982004634 dimer interface [polypeptide binding]; other site 693982004635 [2Fe-2S] cluster binding site [ion binding]; other site 693982004636 Coproporphyrinogen III oxidase [Coenzyme metabolism]; Region: HemF; COG0408 693982004637 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 693982004638 Predicted transcriptional regulator [Transcription]; Region: COG3636 693982004639 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 693982004640 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 693982004641 mce related protein; Region: MCE; pfam02470 693982004642 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 693982004643 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 693982004644 Walker A/P-loop; other site 693982004645 ATP binding site [chemical binding]; other site 693982004646 Q-loop/lid; other site 693982004647 ABC transporter signature motif; other site 693982004648 Walker B; other site 693982004649 D-loop; other site 693982004650 H-loop/switch region; other site 693982004651 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 693982004652 Permease; Region: Permease; pfam02405 693982004653 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 693982004654 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 693982004655 active site 693982004656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982004657 putative substrate translocation pore; other site 693982004658 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 693982004659 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693982004660 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 693982004661 putative active site [active] 693982004662 putative metal binding site [ion binding]; other site 693982004663 malic enzyme; Reviewed; Region: PRK12862 693982004664 Malic enzyme, N-terminal domain; Region: malic; pfam00390 693982004665 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 693982004666 putative NAD(P) binding site [chemical binding]; other site 693982004667 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 693982004668 Autoinducer binding domain; Region: Autoind_bind; pfam03472 693982004669 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982004670 DNA binding residues [nucleotide binding] 693982004671 dimerization interface [polypeptide binding]; other site 693982004672 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 693982004673 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 693982004674 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 693982004675 putative FMN binding site [chemical binding]; other site 693982004676 short chain dehydrogenase; Provisional; Region: PRK06198 693982004677 classical (c) SDRs; Region: SDR_c; cd05233 693982004678 NAD(P) binding site [chemical binding]; other site 693982004679 active site 693982004680 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 693982004681 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982004682 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982004683 DNA binding site [nucleotide binding] 693982004684 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 693982004685 putative ligand binding site [chemical binding]; other site 693982004686 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 693982004687 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693982004688 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693982004689 NAD synthetase; Provisional; Region: PRK13981 693982004690 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 693982004691 multimer interface [polypeptide binding]; other site 693982004692 active site 693982004693 catalytic triad [active] 693982004694 protein interface 1 [polypeptide binding]; other site 693982004695 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 693982004696 homodimer interface [polypeptide binding]; other site 693982004697 NAD binding pocket [chemical binding]; other site 693982004698 ATP binding pocket [chemical binding]; other site 693982004699 Mg binding site [ion binding]; other site 693982004700 active-site loop [active] 693982004701 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 693982004702 Sulfatase; Region: Sulfatase; pfam00884 693982004703 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 693982004704 TadE-like protein; Region: TadE; pfam07811 693982004705 Predicted membrane protein [Function unknown]; Region: COG4655 693982004706 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 693982004707 Predicted transcriptional regulator [Transcription]; Region: COG1959 693982004708 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693982004709 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 693982004710 glutathione-disulfide reductase, plant; Region: gluta_reduc_2; TIGR01424 693982004711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982004712 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693982004713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 693982004714 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 693982004715 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693982004716 active site 693982004717 dimer interface [polypeptide binding]; other site 693982004718 phosphoglycolate phosphatase; Provisional; Region: PRK13222 693982004719 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982004720 motif II; other site 693982004721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 693982004722 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982004723 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693982004724 fumarate hydratase; Reviewed; Region: fumC; PRK00485 693982004725 Class II fumarases; Region: Fumarase_classII; cd01362 693982004726 active site 693982004727 tetramer interface [polypeptide binding]; other site 693982004728 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 693982004729 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693982004730 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693982004731 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693982004732 MarR family; Region: MarR_2; pfam12802 693982004733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 693982004734 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 693982004735 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693982004736 FeS/SAM binding site; other site 693982004737 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 693982004738 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693982004739 EamA-like transporter family; Region: EamA; pfam00892 693982004740 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 693982004741 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 693982004742 GTP binding site; other site 693982004743 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 693982004744 Walker A motif; other site 693982004745 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693982004746 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693982004747 ligand binding site [chemical binding]; other site 693982004748 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 693982004749 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982004750 substrate binding pocket [chemical binding]; other site 693982004751 membrane-bound complex binding site; other site 693982004752 hinge residues; other site 693982004753 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693982004754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982004755 dimer interface [polypeptide binding]; other site 693982004756 conserved gate region; other site 693982004757 putative PBP binding loops; other site 693982004758 ABC-ATPase subunit interface; other site 693982004759 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693982004760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982004761 dimer interface [polypeptide binding]; other site 693982004762 conserved gate region; other site 693982004763 putative PBP binding loops; other site 693982004764 ABC-ATPase subunit interface; other site 693982004765 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 693982004766 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 693982004767 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 693982004768 putative NAD(P) binding site [chemical binding]; other site 693982004769 putative active site [active] 693982004770 Predicted integral membrane protein [Function unknown]; Region: COG5530 693982004771 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 693982004772 Tetratricopeptide repeat; Region: TPR_1; pfam00515 693982004773 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 693982004774 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 693982004775 NAD(P) binding pocket [chemical binding]; other site 693982004776 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693982004777 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 693982004778 A new structural DNA glycosylase; Region: AlkD_like; cd06561 693982004779 active site 693982004780 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982004781 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982004782 putative DNA binding site [nucleotide binding]; other site 693982004783 putative Zn2+ binding site [ion binding]; other site 693982004784 AsnC family; Region: AsnC_trans_reg; pfam01037 693982004785 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 693982004786 putative uracil binding site [chemical binding]; other site 693982004787 putative active site [active] 693982004788 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 693982004789 Catalytic site; other site 693982004790 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 693982004791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982004792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982004793 dimer interface [polypeptide binding]; other site 693982004794 phosphorylation site [posttranslational modification] 693982004795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982004796 ATP binding site [chemical binding]; other site 693982004797 Mg2+ binding site [ion binding]; other site 693982004798 G-X-G motif; other site 693982004799 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 693982004800 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 693982004801 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 693982004802 putative dimer interface [polypeptide binding]; other site 693982004803 active site pocket [active] 693982004804 putative cataytic base [active] 693982004805 cobalamin synthase; Reviewed; Region: cobS; PRK00235 693982004806 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 693982004807 Predicted aspartyl protease [General function prediction only]; Region: COG3577 693982004808 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 693982004809 catalytic motif [active] 693982004810 Catalytic residue [active] 693982004811 ABC-2 type transporter; Region: ABC2_membrane; cl17235 693982004812 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693982004813 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693982004814 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693982004815 Walker A/P-loop; other site 693982004816 ATP binding site [chemical binding]; other site 693982004817 Q-loop/lid; other site 693982004818 ABC transporter signature motif; other site 693982004819 Walker B; other site 693982004820 D-loop; other site 693982004821 H-loop/switch region; other site 693982004822 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982004823 dimerization interface [polypeptide binding]; other site 693982004824 putative DNA binding site [nucleotide binding]; other site 693982004825 putative Zn2+ binding site [ion binding]; other site 693982004826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 693982004827 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982004828 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 693982004829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 693982004830 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 693982004831 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097 693982004832 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097 693982004833 Cache domain; Region: Cache_2; pfam08269 693982004834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693982004835 dimerization interface [polypeptide binding]; other site 693982004836 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693982004837 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693982004838 dimer interface [polypeptide binding]; other site 693982004839 putative CheW interface [polypeptide binding]; other site 693982004840 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 693982004841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169 693982004842 excinuclease ABC subunit B; Provisional; Region: PRK05298 693982004843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693982004844 ATP binding site [chemical binding]; other site 693982004845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693982004846 nucleotide binding region [chemical binding]; other site 693982004847 ATP-binding site [chemical binding]; other site 693982004848 Ultra-violet resistance protein B; Region: UvrB; pfam12344 693982004849 UvrB/uvrC motif; Region: UVR; pfam02151 693982004850 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693982004851 HSP70 interaction site [polypeptide binding]; other site 693982004852 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693982004853 DNA-binding site [nucleotide binding]; DNA binding site 693982004854 RNA-binding motif; other site 693982004855 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 693982004856 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693982004857 FMN binding site [chemical binding]; other site 693982004858 active site 693982004859 catalytic residues [active] 693982004860 substrate binding site [chemical binding]; other site 693982004861 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693982004862 active site 693982004863 DNA binding site [nucleotide binding] 693982004864 Int/Topo IB signature motif; other site 693982004865 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693982004866 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693982004867 catalytic residues [active] 693982004868 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693982004869 catalytic residues [active] 693982004870 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 693982004871 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 693982004872 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 693982004873 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 693982004874 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693982004875 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693982004876 catalytic residues [active] 693982004877 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693982004878 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693982004879 catalytic residues [active] 693982004880 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 693982004881 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693982004882 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982004883 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693982004884 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693982004885 Protein export membrane protein; Region: SecD_SecF; cl14618 693982004886 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 693982004887 catalytic residue [active] 693982004888 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 693982004889 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 693982004890 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 693982004891 Glypican; Region: Glypican; pfam01153 693982004892 Septum formation initiator; Region: DivIC; cl17659 693982004893 Protein of unknown function (DUF904); Region: DUF904; pfam06005 693982004894 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 693982004895 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 693982004896 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 693982004897 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 693982004898 tandem repeat interface [polypeptide binding]; other site 693982004899 oligomer interface [polypeptide binding]; other site 693982004900 active site residues [active] 693982004901 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 693982004902 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 693982004903 gpW; Region: gpW; pfam02831 693982004904 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 693982004905 Transcription antiterminator [Transcription]; Region: NusG; COG0250 693982004906 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 693982004907 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 693982004908 heterodimer interface [polypeptide binding]; other site 693982004909 homodimer interface [polypeptide binding]; other site 693982004910 Helix-turn-helix domain; Region: HTH_36; pfam13730 693982004911 Protein of unknown function (DUF982); Region: DUF982; pfam06169 693982004912 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 693982004913 MT-A70; Region: MT-A70; cl01947 693982004914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982004915 non-specific DNA binding site [nucleotide binding]; other site 693982004916 salt bridge; other site 693982004917 sequence-specific DNA binding site [nucleotide binding]; other site 693982004918 Predicted transcriptional regulator [Transcription]; Region: COG2932 693982004919 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693982004920 Catalytic site [active] 693982004921 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 693982004922 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 693982004923 HNH endonuclease; Region: HNH_3; pfam13392 693982004924 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 693982004925 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693982004926 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982004927 DNA-binding site [nucleotide binding]; DNA binding site 693982004928 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982004929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982004930 homodimer interface [polypeptide binding]; other site 693982004931 catalytic residue [active] 693982004932 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 693982004933 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 693982004934 B3/4 domain; Region: B3_4; pfam03483 693982004935 Protein of unknown function (DUF982); Region: DUF982; pfam06169 693982004936 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 693982004937 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693982004938 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 693982004939 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 693982004940 trimer interface [polypeptide binding]; other site 693982004941 putative metal binding site [ion binding]; other site 693982004942 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 693982004943 metal binding site 2 [ion binding]; metal-binding site 693982004944 putative DNA binding helix; other site 693982004945 metal binding site 1 [ion binding]; metal-binding site 693982004946 dimer interface [polypeptide binding]; other site 693982004947 structural Zn2+ binding site [ion binding]; other site 693982004948 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 693982004949 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693982004950 ABC-ATPase subunit interface; other site 693982004951 dimer interface [polypeptide binding]; other site 693982004952 putative PBP binding regions; other site 693982004953 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 693982004954 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 693982004955 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 693982004956 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 693982004957 metal binding site [ion binding]; metal-binding site 693982004958 Predicted integral membrane protein [Function unknown]; Region: COG5455 693982004959 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 693982004960 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 693982004961 inhibitor binding site; inhibition site 693982004962 active site 693982004963 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 693982004964 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 693982004965 DctM-like transporters; Region: DctM; pfam06808 693982004966 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 693982004967 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 693982004968 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 693982004969 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982004970 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982004971 active site 693982004972 catalytic tetrad [active] 693982004973 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982004974 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982004975 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693982004976 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 693982004977 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 693982004978 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 693982004979 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 693982004980 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693982004981 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982004982 Walker A/P-loop; other site 693982004983 ATP binding site [chemical binding]; other site 693982004984 Q-loop/lid; other site 693982004985 ABC transporter signature motif; other site 693982004986 Walker B; other site 693982004987 D-loop; other site 693982004988 H-loop/switch region; other site 693982004989 TOBE domain; Region: TOBE; pfam03459 693982004990 TOBE domain; Region: TOBE_2; pfam08402 693982004991 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982004992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982004993 dimer interface [polypeptide binding]; other site 693982004994 conserved gate region; other site 693982004995 putative PBP binding loops; other site 693982004996 ABC-ATPase subunit interface; other site 693982004997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982004998 dimer interface [polypeptide binding]; other site 693982004999 conserved gate region; other site 693982005000 putative PBP binding loops; other site 693982005001 ABC-ATPase subunit interface; other site 693982005002 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982005003 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982005004 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982005005 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982005006 DNA binding site [nucleotide binding] 693982005007 domain linker motif; other site 693982005008 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 693982005009 ligand binding site [chemical binding]; other site 693982005010 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 693982005011 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693982005012 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 693982005013 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693982005014 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 693982005015 Helix-turn-helix domain; Region: HTH_18; pfam12833 693982005016 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 693982005017 hydrophobic ligand binding site; other site 693982005018 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982005019 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 693982005020 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693982005021 putative acyl-acceptor binding pocket; other site 693982005022 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 693982005023 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 693982005024 putative NAD(P) binding site [chemical binding]; other site 693982005025 structural Zn binding site [ion binding]; other site 693982005026 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 693982005027 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693982005028 dimer interface [polypeptide binding]; other site 693982005029 active site 693982005030 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 693982005031 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 693982005032 active site 693982005033 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 693982005034 active site 2 [active] 693982005035 active site 1 [active] 693982005036 acyl carrier protein; Provisional; Region: PRK06508 693982005037 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 693982005038 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 693982005039 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982005040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982005041 homodimer interface [polypeptide binding]; other site 693982005042 catalytic residue [active] 693982005043 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 693982005044 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 693982005045 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 693982005046 active site 693982005047 SAM binding site [chemical binding]; other site 693982005048 homodimer interface [polypeptide binding]; other site 693982005049 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 693982005050 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 693982005051 hypothetical protein; Provisional; Region: PRK10621 693982005052 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693982005053 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 693982005054 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982005055 Walker A/P-loop; other site 693982005056 ATP binding site [chemical binding]; other site 693982005057 Q-loop/lid; other site 693982005058 ABC transporter signature motif; other site 693982005059 Walker B; other site 693982005060 D-loop; other site 693982005061 H-loop/switch region; other site 693982005062 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982005063 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982005064 Walker A/P-loop; other site 693982005065 ATP binding site [chemical binding]; other site 693982005066 Q-loop/lid; other site 693982005067 ABC transporter signature motif; other site 693982005068 Walker B; other site 693982005069 D-loop; other site 693982005070 H-loop/switch region; other site 693982005071 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 693982005072 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 693982005073 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982005074 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 693982005075 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982005076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982005077 dimer interface [polypeptide binding]; other site 693982005078 conserved gate region; other site 693982005079 putative PBP binding loops; other site 693982005080 ABC-ATPase subunit interface; other site 693982005081 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 693982005082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982005083 dimer interface [polypeptide binding]; other site 693982005084 conserved gate region; other site 693982005085 putative PBP binding loops; other site 693982005086 ABC-ATPase subunit interface; other site 693982005087 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 693982005088 ANTAR domain; Region: ANTAR; pfam03861 693982005089 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 693982005090 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 693982005091 ligand binding site [chemical binding]; other site 693982005092 regulator interaction site; other site 693982005093 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 693982005094 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 693982005095 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 693982005096 homodimer interface [polypeptide binding]; other site 693982005097 Walker A motif; other site 693982005098 ATP binding site [chemical binding]; other site 693982005099 hydroxycobalamin binding site [chemical binding]; other site 693982005100 Walker B motif; other site 693982005101 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 693982005102 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 693982005103 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 693982005104 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 693982005105 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 693982005106 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 693982005107 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 693982005108 homotrimer interface [polypeptide binding]; other site 693982005109 Walker A motif; other site 693982005110 GTP binding site [chemical binding]; other site 693982005111 Walker B motif; other site 693982005112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 693982005113 FecR protein; Region: FecR; pfam04773 693982005114 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 693982005115 CHASE2 domain; Region: CHASE2; pfam05226 693982005116 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982005117 cyclase homology domain; Region: CHD; cd07302 693982005118 nucleotidyl binding site; other site 693982005119 metal binding site [ion binding]; metal-binding site 693982005120 dimer interface [polypeptide binding]; other site 693982005121 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693982005122 cobyric acid synthase; Provisional; Region: PRK00784 693982005123 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693982005124 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 693982005125 catalytic triad [active] 693982005126 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 693982005127 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 693982005128 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 693982005129 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 693982005130 Walker A/P-loop; other site 693982005131 ATP binding site [chemical binding]; other site 693982005132 Q-loop/lid; other site 693982005133 ABC transporter signature motif; other site 693982005134 Walker B; other site 693982005135 D-loop; other site 693982005136 H-loop/switch region; other site 693982005137 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 693982005138 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 693982005139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982005140 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982005141 dimerization interface [polypeptide binding]; other site 693982005142 methionine synthase I; Validated; Region: PRK07534 693982005143 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 693982005144 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 693982005145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982005146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982005147 homodimer interface [polypeptide binding]; other site 693982005148 catalytic residue [active] 693982005149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 693982005150 YheO-like PAS domain; Region: PAS_6; pfam08348 693982005151 HTH domain; Region: HTH_22; pfam13309 693982005152 Predicted periplasmic protein [Function unknown]; Region: COG3698 693982005153 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 693982005154 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 693982005155 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 693982005156 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 693982005157 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 693982005158 B12 binding site [chemical binding]; other site 693982005159 cobalt ligand [ion binding]; other site 693982005160 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 693982005161 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 693982005162 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 693982005163 putative active site [active] 693982005164 putative cosubstrate binding site; other site 693982005165 putative substrate binding site [chemical binding]; other site 693982005166 catalytic site [active] 693982005167 BA14K-like protein; Region: BA14K; pfam07886 693982005168 Virulence factor; Region: Virulence_fact; pfam13769 693982005169 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 693982005170 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 693982005171 FAD binding site [chemical binding]; other site 693982005172 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 693982005173 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 693982005174 substrate binding pocket [chemical binding]; other site 693982005175 dimer interface [polypeptide binding]; other site 693982005176 inhibitor binding site; inhibition site 693982005177 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 693982005178 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982005179 catalytic loop [active] 693982005180 iron binding site [ion binding]; other site 693982005181 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 693982005182 AAA domain; Region: AAA_33; pfam13671 693982005183 P-loop motif; other site 693982005184 ATP binding site [chemical binding]; other site 693982005185 Chloramphenicol (Cm) binding site [chemical binding]; other site 693982005186 catalytic residue [active] 693982005187 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 693982005188 putative hydrophobic ligand binding site [chemical binding]; other site 693982005189 CLM binding site; other site 693982005190 L1 loop; other site 693982005191 DNA binding site [nucleotide binding] 693982005192 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982005193 dimerization interface [polypeptide binding]; other site 693982005194 putative DNA binding site [nucleotide binding]; other site 693982005195 putative Zn2+ binding site [ion binding]; other site 693982005196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982005197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982005198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982005199 dimerization interface [polypeptide binding]; other site 693982005200 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693982005201 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 693982005202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 693982005203 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 693982005204 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 693982005205 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 693982005206 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 693982005207 putative metal binding site [ion binding]; other site 693982005208 putative homodimer interface [polypeptide binding]; other site 693982005209 putative homotetramer interface [polypeptide binding]; other site 693982005210 putative homodimer-homodimer interface [polypeptide binding]; other site 693982005211 putative allosteric switch controlling residues; other site 693982005212 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 693982005213 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 693982005214 conserved cys residue [active] 693982005215 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982005216 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693982005217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982005218 active site 693982005219 phosphorylation site [posttranslational modification] 693982005220 intermolecular recognition site; other site 693982005221 dimerization interface [polypeptide binding]; other site 693982005222 Response regulator receiver domain; Region: Response_reg; pfam00072 693982005223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982005224 active site 693982005225 phosphorylation site [posttranslational modification] 693982005226 intermolecular recognition site; other site 693982005227 dimerization interface [polypeptide binding]; other site 693982005228 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 693982005229 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982005230 cyclase homology domain; Region: CHD; cd07302 693982005231 nucleotidyl binding site; other site 693982005232 metal binding site [ion binding]; metal-binding site 693982005233 dimer interface [polypeptide binding]; other site 693982005234 RibD C-terminal domain; Region: RibD_C; cl17279 693982005235 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 693982005236 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 693982005237 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 693982005238 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693982005239 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693982005240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 693982005241 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693982005242 transmembrane helices; other site 693982005243 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693982005244 TrkA-C domain; Region: TrkA_C; pfam02080 693982005245 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 693982005246 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 693982005247 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 693982005248 catalytic residue [active] 693982005249 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693982005250 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693982005251 active site 693982005252 Terminase-like family; Region: Terminase_6; pfam03237 693982005253 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 693982005254 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693982005255 BA14K-like protein; Region: BA14K; pfam07886 693982005256 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 693982005257 DnaA box-binding interface [nucleotide binding]; other site 693982005258 Predicted transcriptional regulator [Transcription]; Region: COG2932 693982005259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982005260 non-specific DNA binding site [nucleotide binding]; other site 693982005261 salt bridge; other site 693982005262 sequence-specific DNA binding site [nucleotide binding]; other site 693982005263 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693982005264 Catalytic site [active] 693982005265 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 693982005266 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 693982005267 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 693982005268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 693982005269 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982005270 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 693982005271 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982005272 DNA binding residues [nucleotide binding] 693982005273 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 693982005274 FecR protein; Region: FecR; pfam04773 693982005275 Secretin and TonB N terminus short domain; Region: STN; smart00965 693982005276 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 693982005277 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693982005278 N-terminal plug; other site 693982005279 ligand-binding site [chemical binding]; other site 693982005280 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 693982005281 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693982005282 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 693982005283 Walker A/P-loop; other site 693982005284 ATP binding site [chemical binding]; other site 693982005285 Q-loop/lid; other site 693982005286 ABC transporter signature motif; other site 693982005287 Walker B; other site 693982005288 D-loop; other site 693982005289 H-loop/switch region; other site 693982005290 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 693982005291 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982005292 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 693982005293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 693982005294 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 693982005295 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 693982005296 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 693982005297 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 693982005298 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 693982005299 nudix motif; other site 693982005300 putative catalytic site [active] 693982005301 putative phosphate binding site [ion binding]; other site 693982005302 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693982005303 putative metal binding site [ion binding]; other site 693982005304 TIGR02594 family protein; Region: TIGR02594 693982005305 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 693982005306 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 693982005307 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 693982005308 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 693982005309 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 693982005310 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 693982005311 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982005312 cyclase homology domain; Region: CHD; cd07302 693982005313 nucleotidyl binding site; other site 693982005314 metal binding site [ion binding]; metal-binding site 693982005315 dimer interface [polypeptide binding]; other site 693982005316 Predicted integral membrane protein [Function unknown]; Region: COG5616 693982005317 TPR repeat; Region: TPR_11; pfam13414 693982005318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982005319 binding surface 693982005320 TPR motif; other site 693982005321 cell division protein FtsZ; Provisional; Region: PRK13018 693982005322 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 693982005323 nucleotide binding site [chemical binding]; other site 693982005324 SulA interaction site; other site 693982005325 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 693982005326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982005327 active site 693982005328 motif I; other site 693982005329 motif II; other site 693982005330 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 693982005331 AAA ATPase domain; Region: AAA_16; pfam13191 693982005332 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693982005333 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 693982005334 Walker A/P-loop; other site 693982005335 ATP binding site [chemical binding]; other site 693982005336 Q-loop/lid; other site 693982005337 ABC transporter signature motif; other site 693982005338 Walker B; other site 693982005339 D-loop; other site 693982005340 H-loop/switch region; other site 693982005341 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 693982005342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982005343 dimer interface [polypeptide binding]; other site 693982005344 conserved gate region; other site 693982005345 putative PBP binding loops; other site 693982005346 ABC-ATPase subunit interface; other site 693982005347 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 693982005348 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 693982005349 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693982005350 DNA-binding site [nucleotide binding]; DNA binding site 693982005351 RNA-binding motif; other site 693982005352 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 693982005353 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982005354 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 693982005355 C-terminal domain interface [polypeptide binding]; other site 693982005356 GSH binding site (G-site) [chemical binding]; other site 693982005357 dimer interface [polypeptide binding]; other site 693982005358 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 693982005359 N-terminal domain interface [polypeptide binding]; other site 693982005360 dimer interface [polypeptide binding]; other site 693982005361 substrate binding pocket (H-site) [chemical binding]; other site 693982005362 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982005363 active site 693982005364 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982005365 catalytic tetrad [active] 693982005366 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 693982005367 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982005368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982005369 homodimer interface [polypeptide binding]; other site 693982005370 catalytic residue [active] 693982005371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 693982005372 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693982005373 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 693982005374 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 693982005375 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982005376 cyclase homology domain; Region: CHD; cd07302 693982005377 nucleotidyl binding site; other site 693982005378 metal binding site [ion binding]; metal-binding site 693982005379 dimer interface [polypeptide binding]; other site 693982005380 ketol-acid reductoisomerase; Provisional; Region: PRK05479 693982005381 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 693982005382 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 693982005383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982005384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982005385 macrolide transporter subunit MacA; Provisional; Region: PRK11578 693982005386 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982005387 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 693982005388 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693982005389 Walker A/P-loop; other site 693982005390 ATP binding site [chemical binding]; other site 693982005391 Q-loop/lid; other site 693982005392 ABC transporter signature motif; other site 693982005393 Walker B; other site 693982005394 D-loop; other site 693982005395 H-loop/switch region; other site 693982005396 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693982005397 FtsX-like permease family; Region: FtsX; pfam02687 693982005398 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 693982005399 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 693982005400 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 693982005401 Catalytic site; other site 693982005402 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 693982005403 Phosphotransferase enzyme family; Region: APH; pfam01636 693982005404 putative active site [active] 693982005405 putative substrate binding site [chemical binding]; other site 693982005406 ATP binding site [chemical binding]; other site 693982005407 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 693982005408 benzoate transport; Region: 2A0115; TIGR00895 693982005409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982005410 putative substrate translocation pore; other site 693982005411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982005412 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693982005413 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693982005414 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693982005415 putative active site [active] 693982005416 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 693982005417 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982005418 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982005419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982005420 putative DNA binding site [nucleotide binding]; other site 693982005421 putative Zn2+ binding site [ion binding]; other site 693982005422 AsnC family; Region: AsnC_trans_reg; pfam01037 693982005423 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 693982005424 aspartate racemase; Region: asp_race; TIGR00035 693982005425 Predicted transcriptional regulators [Transcription]; Region: COG1733 693982005426 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 693982005427 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 693982005428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982005429 NAD(P) binding site [chemical binding]; other site 693982005430 active site 693982005431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 693982005432 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693982005433 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982005434 DNA-binding site [nucleotide binding]; DNA binding site 693982005435 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982005436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982005437 homodimer interface [polypeptide binding]; other site 693982005438 catalytic residue [active] 693982005439 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 693982005440 active site 693982005441 hydrophilic channel; other site 693982005442 dimerization interface [polypeptide binding]; other site 693982005443 catalytic residues [active] 693982005444 active site lid [active] 693982005445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 693982005446 EF-hand domain pair; Region: EF_hand_5; pfam13499 693982005447 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 693982005448 Ca2+ binding site [ion binding]; other site 693982005449 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 693982005450 Zn binding site [ion binding]; other site 693982005451 Uncharacterized conserved protein [Function unknown]; Region: COG3482 693982005452 YcaO-like family; Region: YcaO; pfam02624 693982005453 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 693982005454 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 693982005455 cyclase homology domain; Region: CHD; cd07302 693982005456 nucleotidyl binding site; other site 693982005457 metal binding site [ion binding]; metal-binding site 693982005458 dimer interface [polypeptide binding]; other site 693982005459 Predicted ATPase [General function prediction only]; Region: COG3899 693982005460 AAA ATPase domain; Region: AAA_16; pfam13191 693982005461 Predicted ATPase [General function prediction only]; Region: COG3903 693982005462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693982005463 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693982005464 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693982005465 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 693982005466 AAA domain; Region: AAA_30; pfam13604 693982005467 Family description; Region: UvrD_C_2; pfam13538 693982005468 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 693982005469 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 693982005470 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 693982005471 Predicted transcriptional regulator [Transcription]; Region: COG4190 693982005472 Helix-turn-helix domain; Region: HTH_20; pfam12840 693982005473 putative DNA binding site [nucleotide binding]; other site 693982005474 putative Zn2+ binding site [ion binding]; other site 693982005475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 693982005476 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 693982005477 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 693982005478 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 693982005479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982005480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982005481 DNA binding residues [nucleotide binding] 693982005482 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 693982005483 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 693982005484 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 693982005485 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 693982005486 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 693982005487 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 693982005488 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693982005489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982005490 S-adenosylmethionine binding site [chemical binding]; other site 693982005491 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693982005492 DNA-binding site [nucleotide binding]; DNA binding site 693982005493 RNA-binding motif; other site 693982005494 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982005495 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982005496 active site 693982005497 catalytic tetrad [active] 693982005498 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 693982005499 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 693982005500 putative valine binding site [chemical binding]; other site 693982005501 dimer interface [polypeptide binding]; other site 693982005502 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 693982005503 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 693982005504 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693982005505 PYR/PP interface [polypeptide binding]; other site 693982005506 dimer interface [polypeptide binding]; other site 693982005507 TPP binding site [chemical binding]; other site 693982005508 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693982005509 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 693982005510 TPP-binding site [chemical binding]; other site 693982005511 dimer interface [polypeptide binding]; other site 693982005512 HAS barrel domain; Region: HAS-barrel; pfam09378 693982005513 HerA helicase [Replication, recombination, and repair]; Region: COG0433 693982005514 Domain of unknown function DUF87; Region: DUF87; pfam01935 693982005515 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 693982005516 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 693982005517 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 693982005518 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 693982005519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982005520 motif II; other site 693982005521 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693982005522 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693982005523 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 693982005524 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693982005525 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693982005526 protein binding site [polypeptide binding]; other site 693982005527 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693982005528 protein binding site [polypeptide binding]; other site 693982005529 Uncharacterized conserved protein [Function unknown]; Region: COG3603 693982005530 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 693982005531 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 693982005532 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 693982005533 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 693982005534 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 693982005535 HflK protein; Region: hflK; TIGR01933 693982005536 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 693982005537 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 693982005538 folate binding site [chemical binding]; other site 693982005539 NADP+ binding site [chemical binding]; other site 693982005540 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982005541 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 693982005542 putative C-terminal domain interface [polypeptide binding]; other site 693982005543 putative GSH binding site (G-site) [chemical binding]; other site 693982005544 putative dimer interface [polypeptide binding]; other site 693982005545 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 693982005546 dimer interface [polypeptide binding]; other site 693982005547 N-terminal domain interface [polypeptide binding]; other site 693982005548 putative substrate binding pocket (H-site) [chemical binding]; other site 693982005549 thymidylate synthase; Reviewed; Region: thyA; PRK01827 693982005550 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 693982005551 dimerization interface [polypeptide binding]; other site 693982005552 active site 693982005553 Uncharacterized conserved protein [Function unknown]; Region: COG5502 693982005554 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 693982005555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 693982005556 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 693982005557 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 693982005558 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 693982005559 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693982005560 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693982005561 FAD binding domain; Region: FAD_binding_4; pfam01565 693982005562 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 693982005563 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693982005564 Protein export membrane protein; Region: SecD_SecF; cl14618 693982005565 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693982005566 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982005567 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982005568 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 693982005569 Uncharacterized conserved protein [Function unknown]; Region: COG2128 693982005570 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 693982005571 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 693982005572 Part of AAA domain; Region: AAA_19; pfam13245 693982005573 Family description; Region: UvrD_C_2; pfam13538 693982005574 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693982005575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982005576 Coenzyme A binding pocket [chemical binding]; other site 693982005577 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926 693982005578 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693982005579 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982005580 metal binding site [ion binding]; metal-binding site 693982005581 active site 693982005582 I-site; other site 693982005583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 693982005584 CreA protein; Region: CreA; pfam05981 693982005585 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 693982005586 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 693982005587 putative CheA interaction surface; other site 693982005588 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693982005589 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693982005590 dimer interface [polypeptide binding]; other site 693982005591 putative CheW interface [polypeptide binding]; other site 693982005592 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 693982005593 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 693982005594 Cu(I) binding site [ion binding]; other site 693982005595 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 693982005596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982005597 S-adenosylmethionine binding site [chemical binding]; other site 693982005598 Protein of unknown function (DUF968); Region: DUF968; pfam06147 693982005599 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 693982005600 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 693982005601 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 693982005602 active site 693982005603 Nuclear pore component; Region: Nup88; pfam10168 693982005604 Predicted membrane protein [Function unknown]; Region: COG4541 693982005605 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 693982005606 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 693982005607 oligomerization interface [polypeptide binding]; other site 693982005608 active site 693982005609 metal binding site [ion binding]; metal-binding site 693982005610 pantoate--beta-alanine ligase; Region: panC; TIGR00018 693982005611 Pantoate-beta-alanine ligase; Region: PanC; cd00560 693982005612 active site 693982005613 ATP-binding site [chemical binding]; other site 693982005614 pantoate-binding site; other site 693982005615 HXXH motif; other site 693982005616 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 693982005617 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982005618 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 693982005619 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 693982005620 nucleotide binding pocket [chemical binding]; other site 693982005621 K-X-D-G motif; other site 693982005622 catalytic site [active] 693982005623 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 693982005624 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 693982005625 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 693982005626 Dimer interface [polypeptide binding]; other site 693982005627 BRCT sequence motif; other site 693982005628 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 693982005629 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 693982005630 Walker A/P-loop; other site 693982005631 ATP binding site [chemical binding]; other site 693982005632 Q-loop/lid; other site 693982005633 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 693982005634 ABC transporter signature motif; other site 693982005635 Walker B; other site 693982005636 D-loop; other site 693982005637 H-loop/switch region; other site 693982005638 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 693982005639 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 693982005640 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 693982005641 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 693982005642 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 693982005643 nucleotide binding site [chemical binding]; other site 693982005644 SulA interaction site; other site 693982005645 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 693982005646 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 693982005647 Cell division protein FtsA; Region: FtsA; smart00842 693982005648 Cell division protein FtsA; Region: FtsA; pfam14450 693982005649 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 693982005650 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 693982005651 Cell division protein FtsQ; Region: FtsQ; pfam03799 693982005652 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 693982005653 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 693982005654 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693982005655 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 693982005656 amphipathic channel; other site 693982005657 Asn-Pro-Ala signature motifs; other site 693982005658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982005659 metabolite-proton symporter; Region: 2A0106; TIGR00883 693982005660 putative substrate translocation pore; other site 693982005661 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 693982005662 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 693982005663 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 693982005664 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693982005665 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693982005666 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693982005667 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 693982005668 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 693982005669 homodimer interface [polypeptide binding]; other site 693982005670 active site 693982005671 cell division protein FtsW; Region: ftsW; TIGR02614 693982005672 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 693982005673 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693982005674 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693982005675 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 693982005676 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 693982005677 Mg++ binding site [ion binding]; other site 693982005678 putative catalytic motif [active] 693982005679 putative substrate binding site [chemical binding]; other site 693982005680 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 693982005681 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693982005682 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693982005683 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693982005684 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 693982005685 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693982005686 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693982005687 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693982005688 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 693982005689 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 693982005690 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693982005691 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 693982005692 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 693982005693 MraW methylase family; Region: Methyltransf_5; cl17771 693982005694 cell division protein MraZ; Reviewed; Region: PRK00326 693982005695 MraZ protein; Region: MraZ; pfam02381 693982005696 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982005697 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 693982005698 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693982005699 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693982005700 catalytic residue [active] 693982005701 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 693982005702 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 693982005703 amidase catalytic site [active] 693982005704 Zn binding residues [ion binding]; other site 693982005705 substrate binding site [chemical binding]; other site 693982005706 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982005707 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 693982005708 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 693982005709 putative metal binding site [ion binding]; other site 693982005710 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693982005711 HSP70 interaction site [polypeptide binding]; other site 693982005712 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 693982005713 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 693982005714 active site 693982005715 ADP/pyrophosphate binding site [chemical binding]; other site 693982005716 allosteric effector site; other site 693982005717 dimerization interface [polypeptide binding]; other site 693982005718 fructose-1,6-bisphosphate binding site; other site 693982005719 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693982005720 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 693982005721 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693982005722 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693982005723 catalytic residue [active] 693982005724 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 693982005725 Beta-lactamase; Region: Beta-lactamase; pfam00144 693982005726 S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379 693982005727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982005728 S-adenosylmethionine binding site [chemical binding]; other site 693982005729 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 693982005730 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 693982005731 active site 693982005732 lytic murein transglycosylase; Region: MltB_2; TIGR02283 693982005733 murein hydrolase B; Provisional; Region: PRK10760; cl17906 693982005734 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982005735 EamA-like transporter family; Region: EamA; cl17759 693982005736 EamA-like transporter family; Region: EamA; pfam00892 693982005737 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 693982005738 FAD binding site [chemical binding]; other site 693982005739 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982005740 dimerization interface [polypeptide binding]; other site 693982005741 putative DNA binding site [nucleotide binding]; other site 693982005742 putative Zn2+ binding site [ion binding]; other site 693982005743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982005744 S-adenosylmethionine binding site [chemical binding]; other site 693982005745 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 693982005746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982005747 Walker A/P-loop; other site 693982005748 ATP binding site [chemical binding]; other site 693982005749 Q-loop/lid; other site 693982005750 ABC transporter signature motif; other site 693982005751 Walker B; other site 693982005752 D-loop; other site 693982005753 H-loop/switch region; other site 693982005754 ABC transporter; Region: ABC_tran_2; pfam12848 693982005755 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693982005756 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 693982005757 B1 nucleotide binding pocket [chemical binding]; other site 693982005758 B2 nucleotide binding pocket [chemical binding]; other site 693982005759 CAS motifs; other site 693982005760 active site 693982005761 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 693982005762 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693982005763 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693982005764 EamA-like transporter family; Region: EamA; pfam00892 693982005765 thiamine pyrophosphate protein; Validated; Region: PRK08199 693982005766 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693982005767 PYR/PP interface [polypeptide binding]; other site 693982005768 dimer interface [polypeptide binding]; other site 693982005769 TPP binding site [chemical binding]; other site 693982005770 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693982005771 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 693982005772 TPP-binding site [chemical binding]; other site 693982005773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 693982005774 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 693982005775 active site 693982005776 catalytic residues [active] 693982005777 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982005778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 693982005779 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693982005780 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693982005781 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982005782 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693982005783 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693982005784 P-loop; other site 693982005785 Magnesium ion binding site [ion binding]; other site 693982005786 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 693982005787 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 693982005788 putative active site [active] 693982005789 metal binding site [ion binding]; metal-binding site 693982005790 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 693982005791 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 693982005792 NAD(P) binding site [chemical binding]; other site 693982005793 catalytic residues [active] 693982005794 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 693982005795 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693982005796 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 693982005797 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 693982005798 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693982005799 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693982005800 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693982005801 putative active site [active] 693982005802 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 693982005803 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 693982005804 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982005805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982005806 dimer interface [polypeptide binding]; other site 693982005807 conserved gate region; other site 693982005808 putative PBP binding loops; other site 693982005809 ABC-ATPase subunit interface; other site 693982005810 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982005811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982005812 dimer interface [polypeptide binding]; other site 693982005813 conserved gate region; other site 693982005814 putative PBP binding loops; other site 693982005815 ABC-ATPase subunit interface; other site 693982005816 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693982005817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982005818 Walker A/P-loop; other site 693982005819 ATP binding site [chemical binding]; other site 693982005820 Q-loop/lid; other site 693982005821 ABC transporter signature motif; other site 693982005822 Walker B; other site 693982005823 D-loop; other site 693982005824 H-loop/switch region; other site 693982005825 TOBE domain; Region: TOBE_2; pfam08402 693982005826 riboflavin synthase subunit beta; Provisional; Region: PRK12419 693982005827 active site 693982005828 homopentamer interface [polypeptide binding]; other site 693982005829 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693982005830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982005831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982005832 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 693982005833 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693982005834 N-terminal plug; other site 693982005835 ligand-binding site [chemical binding]; other site 693982005836 Transposase, Mutator family; Region: Transposase_mut; pfam00872 693982005837 MULE transposase domain; Region: MULE; pfam10551 693982005838 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 693982005839 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 693982005840 substrate binding site [chemical binding]; other site 693982005841 dimer interface [polypeptide binding]; other site 693982005842 triosephosphate isomerase; Provisional; Region: PRK14565 693982005843 catalytic triad [active] 693982005844 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693982005845 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 693982005846 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693982005847 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693982005848 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 693982005849 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 693982005850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982005851 active site 693982005852 motif I; other site 693982005853 motif II; other site 693982005854 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 693982005855 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 693982005856 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693982005857 nucleotide binding site [chemical binding]; other site 693982005858 Uncharacterized conserved protein [Function unknown]; Region: COG3347 693982005859 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 693982005860 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 693982005861 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 693982005862 intersubunit interface [polypeptide binding]; other site 693982005863 active site 693982005864 Zn2+ binding site [ion binding]; other site 693982005865 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693982005866 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 693982005867 putative ligand binding site [chemical binding]; other site 693982005868 putative NAD binding site [chemical binding]; other site 693982005869 catalytic site [active] 693982005870 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 693982005871 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 693982005872 putative N- and C-terminal domain interface [polypeptide binding]; other site 693982005873 putative active site [active] 693982005874 MgATP binding site [chemical binding]; other site 693982005875 catalytic site [active] 693982005876 metal binding site [ion binding]; metal-binding site 693982005877 putative xylulose binding site [chemical binding]; other site 693982005878 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693982005879 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 693982005880 Walker A/P-loop; other site 693982005881 ATP binding site [chemical binding]; other site 693982005882 Q-loop/lid; other site 693982005883 ABC transporter signature motif; other site 693982005884 Walker B; other site 693982005885 D-loop; other site 693982005886 H-loop/switch region; other site 693982005887 TOBE domain; Region: TOBE_2; pfam08402 693982005888 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693982005889 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982005890 Walker A/P-loop; other site 693982005891 ATP binding site [chemical binding]; other site 693982005892 Q-loop/lid; other site 693982005893 ABC transporter signature motif; other site 693982005894 Walker B; other site 693982005895 D-loop; other site 693982005896 H-loop/switch region; other site 693982005897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693982005898 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982005899 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693982005900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982005901 dimer interface [polypeptide binding]; other site 693982005902 conserved gate region; other site 693982005903 putative PBP binding loops; other site 693982005904 ABC-ATPase subunit interface; other site 693982005905 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982005906 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982005907 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 693982005908 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 693982005909 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982005910 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982005911 DNA binding residues [nucleotide binding] 693982005912 dimerization interface [polypeptide binding]; other site 693982005913 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693982005914 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 693982005915 Walker A/P-loop; other site 693982005916 ATP binding site [chemical binding]; other site 693982005917 Q-loop/lid; other site 693982005918 ABC transporter signature motif; other site 693982005919 Walker B; other site 693982005920 D-loop; other site 693982005921 H-loop/switch region; other site 693982005922 TOBE domain; Region: TOBE_2; pfam08402 693982005923 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 693982005924 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693982005925 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982005926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982005927 putative PBP binding loops; other site 693982005928 ABC-ATPase subunit interface; other site 693982005929 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982005930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982005931 dimer interface [polypeptide binding]; other site 693982005932 conserved gate region; other site 693982005933 putative PBP binding loops; other site 693982005934 ABC-ATPase subunit interface; other site 693982005935 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693982005936 classical (c) SDRs; Region: SDR_c; cd05233 693982005937 NAD(P) binding site [chemical binding]; other site 693982005938 active site 693982005939 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 693982005940 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 693982005941 conserved cys residue [active] 693982005942 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982005943 Uncharacterized conserved protein [Function unknown]; Region: COG3246 693982005944 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531 693982005945 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693982005946 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693982005947 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693982005948 active site 693982005949 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693982005950 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693982005951 active site 693982005952 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 693982005953 CoA binding domain; Region: CoA_binding_2; pfam13380 693982005954 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 693982005955 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 693982005956 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 693982005957 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693982005958 substrate binding site [chemical binding]; other site 693982005959 oxyanion hole (OAH) forming residues; other site 693982005960 trimer interface [polypeptide binding]; other site 693982005961 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982005962 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 693982005963 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982005964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982005965 dimer interface [polypeptide binding]; other site 693982005966 conserved gate region; other site 693982005967 ABC-ATPase subunit interface; other site 693982005968 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982005969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982005970 dimer interface [polypeptide binding]; other site 693982005971 conserved gate region; other site 693982005972 ABC-ATPase subunit interface; other site 693982005973 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 693982005974 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982005975 Walker A/P-loop; other site 693982005976 ATP binding site [chemical binding]; other site 693982005977 Q-loop/lid; other site 693982005978 ABC transporter signature motif; other site 693982005979 Walker B; other site 693982005980 D-loop; other site 693982005981 H-loop/switch region; other site 693982005982 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982005983 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982005984 Walker A/P-loop; other site 693982005985 ATP binding site [chemical binding]; other site 693982005986 Q-loop/lid; other site 693982005987 ABC transporter signature motif; other site 693982005988 Walker B; other site 693982005989 D-loop; other site 693982005990 H-loop/switch region; other site 693982005991 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982005992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982005993 sequence-specific DNA binding site [nucleotide binding]; other site 693982005994 salt bridge; other site 693982005995 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982005996 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 693982005997 Predicted acyl esterases [General function prediction only]; Region: COG2936 693982005998 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693982005999 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 693982006000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 693982006001 ACT domain; Region: ACT_3; pfam10000 693982006002 Family description; Region: ACT_7; pfam13840 693982006003 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 693982006004 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982006005 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982006006 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 693982006007 putative substrate binding pocket [chemical binding]; other site 693982006008 dimerization interface [polypeptide binding]; other site 693982006009 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 693982006010 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 693982006011 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693982006012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982006013 Walker A/P-loop; other site 693982006014 ATP binding site [chemical binding]; other site 693982006015 Q-loop/lid; other site 693982006016 ABC transporter signature motif; other site 693982006017 Walker B; other site 693982006018 D-loop; other site 693982006019 H-loop/switch region; other site 693982006020 TOBE domain; Region: TOBE_2; pfam08402 693982006021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982006022 dimer interface [polypeptide binding]; other site 693982006023 conserved gate region; other site 693982006024 putative PBP binding loops; other site 693982006025 ABC-ATPase subunit interface; other site 693982006026 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982006027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982006028 dimer interface [polypeptide binding]; other site 693982006029 conserved gate region; other site 693982006030 putative PBP binding loops; other site 693982006031 ABC-ATPase subunit interface; other site 693982006032 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 693982006033 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 693982006034 tetrameric interface [polypeptide binding]; other site 693982006035 NAD binding site [chemical binding]; other site 693982006036 catalytic residues [active] 693982006037 substrate binding site [chemical binding]; other site 693982006038 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 693982006039 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693982006040 N-terminal plug; other site 693982006041 ligand-binding site [chemical binding]; other site 693982006042 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 693982006043 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 693982006044 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 693982006045 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 693982006046 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 693982006047 putative ligand binding residues [chemical binding]; other site 693982006048 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 693982006049 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982006050 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693982006051 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 693982006052 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 693982006053 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693982006054 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982006055 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693982006056 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 693982006057 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693982006058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982006059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982006060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693982006061 dimerization interface [polypeptide binding]; other site 693982006062 Predicted membrane protein [Function unknown]; Region: COG4425 693982006063 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 693982006064 methionine gamma-lyase; Validated; Region: PRK07049 693982006065 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693982006066 homodimer interface [polypeptide binding]; other site 693982006067 substrate-cofactor binding pocket; other site 693982006068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982006069 catalytic residue [active] 693982006070 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 693982006071 dimer interface [polypeptide binding]; other site 693982006072 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982006073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982006074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982006075 enoyl-CoA hydratase; Provisional; Region: PRK05980 693982006076 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693982006077 substrate binding site [chemical binding]; other site 693982006078 oxyanion hole (OAH) forming residues; other site 693982006079 trimer interface [polypeptide binding]; other site 693982006080 Predicted integral membrane protein [Function unknown]; Region: COG5500 693982006081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 693982006082 Putative glucoamylase; Region: Glycoamylase; pfam10091 693982006083 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 693982006084 Uncharacterized conserved protein [Function unknown]; Region: COG1944 693982006085 YcaO-like family; Region: YcaO; pfam02624 693982006086 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 693982006087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982006088 TPR motif; other site 693982006089 binding surface 693982006090 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 693982006091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982006092 Coenzyme A binding pocket [chemical binding]; other site 693982006093 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 693982006094 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 693982006095 active site 693982006096 substrate binding site [chemical binding]; other site 693982006097 FMN binding site [chemical binding]; other site 693982006098 putative catalytic residues [active] 693982006099 topology modulation protein; Reviewed; Region: PRK08118 693982006100 AAA domain; Region: AAA_17; pfam13207 693982006101 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 693982006102 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982006103 motif II; other site 693982006104 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693982006105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982006106 Coenzyme A binding pocket [chemical binding]; other site 693982006107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 693982006108 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 693982006109 replicative DNA helicase; Provisional; Region: PRK05973 693982006110 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 693982006111 dimer interface [polypeptide binding]; other site 693982006112 substrate binding site [chemical binding]; other site 693982006113 metal binding site [ion binding]; metal-binding site 693982006114 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 693982006115 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 693982006116 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 693982006117 Acid Phosphatase; Region: Acid_PPase; cl17256 693982006118 TrbC/VIRB2 family; Region: TrbC; cl01583 693982006119 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 693982006120 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 693982006121 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 693982006122 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 693982006123 Putative phage tail protein; Region: Phage-tail_3; pfam13550 693982006124 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 693982006125 Interdomain contacts; other site 693982006126 Cytokine receptor motif; other site 693982006127 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 693982006128 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 693982006129 Phage major tail protein 2; Region: Phage_tail_2; cl11463 693982006130 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 693982006131 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 693982006132 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 693982006133 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 693982006134 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 693982006135 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 693982006136 Phage capsid family; Region: Phage_capsid; pfam05065 693982006137 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 693982006138 Phage-related protein [Function unknown]; Region: COG4695 693982006139 Phage portal protein; Region: Phage_portal; pfam04860 693982006140 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 693982006141 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 693982006142 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 693982006143 DNA methylase; Region: N6_N4_Mtase; pfam01555 693982006144 XcyI restriction endonuclease; Region: RE_XcyI; pfam09571 693982006145 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 693982006146 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693982006147 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693982006148 catalytic residues [active] 693982006149 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982006150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982006151 non-specific DNA binding site [nucleotide binding]; other site 693982006152 salt bridge; other site 693982006153 sequence-specific DNA binding site [nucleotide binding]; other site 693982006154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982006155 Coenzyme A binding pocket [chemical binding]; other site 693982006156 Transcriptional regulator; Region: Rrf2; cl17282 693982006157 GcrA cell cycle regulator; Region: GcrA; cl11564 693982006158 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693982006159 RecT family; Region: RecT; pfam03837 693982006160 Helix-turn-helix domain; Region: HTH_17; pfam12728 693982006161 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693982006162 active site 693982006163 catalytic residues [active] 693982006164 DNA binding site [nucleotide binding] 693982006165 Int/Topo IB signature motif; other site 693982006166 Uncharacterized conserved protein [Function unknown]; Region: COG2968 693982006167 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 693982006168 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 693982006169 Uncharacterized conserved protein [Function unknown]; Region: COG0432 693982006170 Uncharacterized conserved protein [Function unknown]; Region: COG5507 693982006171 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693982006172 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693982006173 catalytic residue [active] 693982006174 Uncharacterized conserved protein [Function unknown]; Region: COG4274 693982006175 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 693982006176 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 693982006177 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 693982006178 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 693982006179 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982006180 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693982006181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982006182 DNA binding residues [nucleotide binding] 693982006183 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 693982006184 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693982006185 NAD(P) binding site [chemical binding]; other site 693982006186 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 693982006187 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 693982006188 substrate-cofactor binding pocket; other site 693982006189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982006190 catalytic residue [active] 693982006191 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 693982006192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693982006193 ATP binding site [chemical binding]; other site 693982006194 putative Mg++ binding site [ion binding]; other site 693982006195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693982006196 nucleotide binding region [chemical binding]; other site 693982006197 ATP-binding site [chemical binding]; other site 693982006198 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 693982006199 HRDC domain; Region: HRDC; pfam00570 693982006200 DNA primase; Validated; Region: dnaG; PRK05667 693982006201 CHC2 zinc finger; Region: zf-CHC2; cl17510 693982006202 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 693982006203 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 693982006204 active site 693982006205 metal binding site [ion binding]; metal-binding site 693982006206 interdomain interaction site; other site 693982006207 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 693982006208 Uncharacterized conserved protein [Function unknown]; Region: COG1610 693982006209 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 693982006210 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 693982006211 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 693982006212 catalytic site [active] 693982006213 subunit interface [polypeptide binding]; other site 693982006214 LysR family transcriptional regulator; Provisional; Region: PRK14997 693982006215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982006216 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693982006217 putative effector binding pocket; other site 693982006218 dimerization interface [polypeptide binding]; other site 693982006219 short chain dehydrogenase; Provisional; Region: PRK06500 693982006220 classical (c) SDRs; Region: SDR_c; cd05233 693982006221 NAD(P) binding site [chemical binding]; other site 693982006222 active site 693982006223 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 693982006224 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693982006225 aspartate aminotransferase; Provisional; Region: PRK05764 693982006226 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982006227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982006228 homodimer interface [polypeptide binding]; other site 693982006229 catalytic residue [active] 693982006230 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 693982006231 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 693982006232 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 693982006233 EamA-like transporter family; Region: EamA; pfam00892 693982006234 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693982006235 DNA-binding site [nucleotide binding]; DNA binding site 693982006236 RNA-binding motif; other site 693982006237 BA14K-like protein; Region: BA14K; pfam07886 693982006238 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693982006239 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 693982006240 Bacterial SH3 domain; Region: SH3_3; pfam08239 693982006241 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 693982006242 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693982006243 MarR family; Region: MarR_2; pfam12802 693982006244 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982006245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982006246 active site 693982006247 phosphorylation site [posttranslational modification] 693982006248 intermolecular recognition site; other site 693982006249 dimerization interface [polypeptide binding]; other site 693982006250 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982006251 DNA binding site [nucleotide binding] 693982006252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982006253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693982006254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 693982006255 dimer interface [polypeptide binding]; other site 693982006256 phosphorylation site [posttranslational modification] 693982006257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982006258 ATP binding site [chemical binding]; other site 693982006259 Mg2+ binding site [ion binding]; other site 693982006260 G-X-G motif; other site 693982006261 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 693982006262 dimer interface [polypeptide binding]; other site 693982006263 putative tRNA-binding site [nucleotide binding]; other site 693982006264 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 693982006265 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 693982006266 Uncharacterized conserved protein [Function unknown]; Region: COG5465 693982006267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 693982006268 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 693982006269 Uncharacterized conserved protein [Function unknown]; Region: COG1565 693982006270 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 693982006271 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 693982006272 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 693982006273 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 693982006274 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 693982006275 active site 693982006276 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 693982006277 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 693982006278 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693982006279 active site 693982006280 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693982006281 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 693982006282 tetramer interface [polypeptide binding]; other site 693982006283 active site 693982006284 Mg2+/Mn2+ binding site [ion binding]; other site 693982006285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 693982006286 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 693982006287 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693982006288 NAD(P) binding site [chemical binding]; other site 693982006289 catalytic residues [active] 693982006290 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 693982006291 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693982006292 Benzoate membrane transport protein; Region: BenE; pfam03594 693982006293 benzoate transporter; Region: benE; TIGR00843 693982006294 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 693982006295 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 693982006296 5S rRNA interface [nucleotide binding]; other site 693982006297 CTC domain interface [polypeptide binding]; other site 693982006298 L16 interface [polypeptide binding]; other site 693982006299 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 693982006300 putative active site [active] 693982006301 catalytic residue [active] 693982006302 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 693982006303 GTP-binding protein YchF; Reviewed; Region: PRK09601 693982006304 YchF GTPase; Region: YchF; cd01900 693982006305 G1 box; other site 693982006306 GTP/Mg2+ binding site [chemical binding]; other site 693982006307 Switch I region; other site 693982006308 G2 box; other site 693982006309 Switch II region; other site 693982006310 G3 box; other site 693982006311 G4 box; other site 693982006312 G5 box; other site 693982006313 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 693982006314 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 693982006315 putative active site [active] 693982006316 putative catalytic site [active] 693982006317 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 693982006318 putative active site [active] 693982006319 putative catalytic site [active] 693982006320 Domain of unknown function (DUF1873); Region: DUF1873; pfam08969 693982006321 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693982006322 active site 693982006323 Predicted small metal-binding protein [Function unknown]; Region: COG5466 693982006324 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 693982006325 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 693982006326 active site 693982006327 NTP binding site [chemical binding]; other site 693982006328 metal binding triad [ion binding]; metal-binding site 693982006329 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 693982006330 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 693982006331 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 693982006332 putative active site [active] 693982006333 putative CoA binding site [chemical binding]; other site 693982006334 nudix motif; other site 693982006335 metal binding site [ion binding]; metal-binding site 693982006336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 693982006337 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 693982006338 MoxR-like ATPases [General function prediction only]; Region: COG0714 693982006339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982006340 Walker A motif; other site 693982006341 ATP binding site [chemical binding]; other site 693982006342 Walker B motif; other site 693982006343 arginine finger; other site 693982006344 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 693982006345 Protein of unknown function DUF58; Region: DUF58; pfam01882 693982006346 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 693982006347 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 693982006348 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 693982006349 CARDB; Region: CARDB; pfam07705 693982006350 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 693982006351 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693982006352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982006353 Coenzyme A binding pocket [chemical binding]; other site 693982006354 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 693982006355 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 693982006356 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 693982006357 putative dimer interface [polypeptide binding]; other site 693982006358 N-terminal domain interface [polypeptide binding]; other site 693982006359 putative substrate binding pocket (H-site) [chemical binding]; other site 693982006360 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 693982006361 FIC domain binding interface [polypeptide binding]; other site 693982006362 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 693982006363 Fic/DOC family; Region: Fic; cl00960 693982006364 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 693982006365 nudix motif; other site 693982006366 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693982006367 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 693982006368 putative active site [active] 693982006369 putative metal binding site [ion binding]; other site 693982006370 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693982006371 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 693982006372 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982006373 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982006374 DNA binding residues [nucleotide binding] 693982006375 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 693982006376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 693982006377 putative active site [active] 693982006378 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 693982006379 2-isopropylmalate synthase; Validated; Region: PRK03739 693982006380 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 693982006381 active site 693982006382 catalytic residues [active] 693982006383 metal binding site [ion binding]; metal-binding site 693982006384 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 693982006385 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 693982006386 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 693982006387 oligomer interface [polypeptide binding]; other site 693982006388 active site residues [active] 693982006389 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 693982006390 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693982006391 N-terminal plug; other site 693982006392 ligand-binding site [chemical binding]; other site 693982006393 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 693982006394 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693982006395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982006396 Coenzyme A binding pocket [chemical binding]; other site 693982006397 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 693982006398 Phosphotransferase enzyme family; Region: APH; pfam01636 693982006399 active site 693982006400 ATP binding site [chemical binding]; other site 693982006401 antibiotic binding site [chemical binding]; other site 693982006402 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 693982006403 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 693982006404 Cation efflux family; Region: Cation_efflux; cl00316 693982006405 anthranilate synthase; Provisional; Region: PRK13566 693982006406 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 693982006407 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 693982006408 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 693982006409 glutamine binding [chemical binding]; other site 693982006410 catalytic triad [active] 693982006411 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 693982006412 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693982006413 N-terminal plug; other site 693982006414 ligand-binding site [chemical binding]; other site 693982006415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 693982006416 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 693982006417 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 693982006418 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 693982006419 Potassium binding sites [ion binding]; other site 693982006420 Cesium cation binding sites [ion binding]; other site 693982006421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 693982006422 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 693982006423 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 693982006424 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982006425 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 693982006426 putative active site [active] 693982006427 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 693982006428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 693982006429 thymidine kinase; Provisional; Region: PRK04296 693982006430 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693982006431 ATP binding site [chemical binding]; other site 693982006432 Walker A motif; other site 693982006433 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 693982006434 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 693982006435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982006436 dimer interface [polypeptide binding]; other site 693982006437 conserved gate region; other site 693982006438 putative PBP binding loops; other site 693982006439 ABC-ATPase subunit interface; other site 693982006440 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 693982006441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982006442 Walker A/P-loop; other site 693982006443 ATP binding site [chemical binding]; other site 693982006444 Q-loop/lid; other site 693982006445 ABC transporter signature motif; other site 693982006446 Walker B; other site 693982006447 D-loop; other site 693982006448 H-loop/switch region; other site 693982006449 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 693982006450 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 693982006451 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 693982006452 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 693982006453 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982006454 dimerization interface [polypeptide binding]; other site 693982006455 putative DNA binding site [nucleotide binding]; other site 693982006456 putative Zn2+ binding site [ion binding]; other site 693982006457 AAA domain; Region: AAA_33; pfam13671 693982006458 AAA domain; Region: AAA_17; pfam13207 693982006459 omega amino acid--pyruvate transaminase; Provisional; Region: PRK13360 693982006460 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693982006461 inhibitor-cofactor binding pocket; inhibition site 693982006462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982006463 catalytic residue [active] 693982006464 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 693982006465 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693982006466 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 693982006467 active site 693982006468 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 693982006469 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 693982006470 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 693982006471 active site 693982006472 catalytic site [active] 693982006473 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693982006474 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 693982006475 substrate binding site [chemical binding]; other site 693982006476 ATP binding site [chemical binding]; other site 693982006477 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 693982006478 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982006479 Walker A/P-loop; other site 693982006480 ATP binding site [chemical binding]; other site 693982006481 Q-loop/lid; other site 693982006482 ABC transporter signature motif; other site 693982006483 Walker B; other site 693982006484 D-loop; other site 693982006485 H-loop/switch region; other site 693982006486 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 693982006487 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982006488 Walker A/P-loop; other site 693982006489 ATP binding site [chemical binding]; other site 693982006490 Q-loop/lid; other site 693982006491 ABC transporter signature motif; other site 693982006492 Walker B; other site 693982006493 D-loop; other site 693982006494 H-loop/switch region; other site 693982006495 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982006496 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982006497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982006498 ABC-ATPase subunit interface; other site 693982006499 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982006500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982006501 dimer interface [polypeptide binding]; other site 693982006502 conserved gate region; other site 693982006503 putative PBP binding loops; other site 693982006504 ABC-ATPase subunit interface; other site 693982006505 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982006506 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 693982006507 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 693982006508 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 693982006509 active site 693982006510 dimer interface [polypeptide binding]; other site 693982006511 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 693982006512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982006513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982006514 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 693982006515 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 693982006516 oligomeric interface; other site 693982006517 putative active site [active] 693982006518 homodimer interface [polypeptide binding]; other site 693982006519 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 693982006520 apolar tunnel; other site 693982006521 heme binding site [chemical binding]; other site 693982006522 dimerization interface [polypeptide binding]; other site 693982006523 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 693982006524 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 693982006525 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 693982006526 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 693982006527 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 693982006528 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 693982006529 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 693982006530 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 693982006531 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 693982006532 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 693982006533 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 693982006534 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 693982006535 putative hemin binding site; other site 693982006536 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693982006537 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693982006538 ABC-ATPase subunit interface; other site 693982006539 dimer interface [polypeptide binding]; other site 693982006540 putative PBP binding regions; other site 693982006541 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 693982006542 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693982006543 Walker A/P-loop; other site 693982006544 ATP binding site [chemical binding]; other site 693982006545 Q-loop/lid; other site 693982006546 ABC transporter signature motif; other site 693982006547 Walker B; other site 693982006548 D-loop; other site 693982006549 H-loop/switch region; other site 693982006550 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693982006551 GAF domain; Region: GAF; pfam01590 693982006552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982006553 PAS fold; Region: PAS_3; pfam08447 693982006554 putative active site [active] 693982006555 heme pocket [chemical binding]; other site 693982006556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 693982006557 HWE histidine kinase; Region: HWE_HK; pfam07536 693982006558 RNA polymerase sigma factor; Provisional; Region: PRK12516 693982006559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982006560 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982006561 DNA binding residues [nucleotide binding] 693982006562 two-component response regulator; Provisional; Region: PRK09191 693982006563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982006564 active site 693982006565 phosphorylation site [posttranslational modification] 693982006566 intermolecular recognition site; other site 693982006567 dimerization interface [polypeptide binding]; other site 693982006568 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 693982006569 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 693982006570 N- and C-terminal domain interface [polypeptide binding]; other site 693982006571 active site 693982006572 MgATP binding site [chemical binding]; other site 693982006573 catalytic site [active] 693982006574 metal binding site [ion binding]; metal-binding site 693982006575 carbohydrate binding site [chemical binding]; other site 693982006576 putative homodimer interface [polypeptide binding]; other site 693982006577 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 693982006578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982006579 motif II; other site 693982006580 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 693982006581 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 693982006582 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 693982006583 sorbitol dehydrogenase; Provisional; Region: PRK07067 693982006584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982006585 NAD(P) binding site [chemical binding]; other site 693982006586 active site 693982006587 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693982006588 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982006589 Walker A/P-loop; other site 693982006590 ATP binding site [chemical binding]; other site 693982006591 Q-loop/lid; other site 693982006592 ABC transporter signature motif; other site 693982006593 Walker B; other site 693982006594 D-loop; other site 693982006595 H-loop/switch region; other site 693982006596 TOBE domain; Region: TOBE_2; pfam08402 693982006597 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982006598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982006599 dimer interface [polypeptide binding]; other site 693982006600 conserved gate region; other site 693982006601 putative PBP binding loops; other site 693982006602 ABC-ATPase subunit interface; other site 693982006603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982006604 dimer interface [polypeptide binding]; other site 693982006605 conserved gate region; other site 693982006606 putative PBP binding loops; other site 693982006607 ABC-ATPase subunit interface; other site 693982006608 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982006609 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982006610 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 693982006611 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 693982006612 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 693982006613 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693982006614 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 693982006615 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 693982006616 homodimer interface [polypeptide binding]; other site 693982006617 active site 693982006618 FMN binding site [chemical binding]; other site 693982006619 substrate binding site [chemical binding]; other site 693982006620 4Fe-4S binding domain; Region: Fer4_6; pfam12837 693982006621 4Fe-4S binding domain; Region: Fer4; pfam00037 693982006622 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 693982006623 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 693982006624 putative NAD(P) binding site [chemical binding]; other site 693982006625 LysR family transcriptional regulator; Provisional; Region: PRK14997 693982006626 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982006627 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 693982006628 putative effector binding pocket; other site 693982006629 putative dimerization interface [polypeptide binding]; other site 693982006630 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 693982006631 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982006632 catalytic loop [active] 693982006633 iron binding site [ion binding]; other site 693982006634 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982006635 cyclase homology domain; Region: CHD; cd07302 693982006636 nucleotidyl binding site; other site 693982006637 metal binding site [ion binding]; metal-binding site 693982006638 dimer interface [polypeptide binding]; other site 693982006639 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 693982006640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982006641 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 693982006642 allantoate amidohydrolase; Reviewed; Region: PRK12893 693982006643 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 693982006644 active site 693982006645 metal binding site [ion binding]; metal-binding site 693982006646 dimer interface [polypeptide binding]; other site 693982006647 phenylhydantoinase; Validated; Region: PRK08323 693982006648 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 693982006649 tetramer interface [polypeptide binding]; other site 693982006650 active site 693982006651 Predicted mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: COG4101 693982006652 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 693982006653 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693982006654 Walker A/P-loop; other site 693982006655 ATP binding site [chemical binding]; other site 693982006656 Q-loop/lid; other site 693982006657 ABC transporter signature motif; other site 693982006658 Walker B; other site 693982006659 D-loop; other site 693982006660 H-loop/switch region; other site 693982006661 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693982006662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982006663 Coenzyme A binding pocket [chemical binding]; other site 693982006664 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693982006665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982006666 dimer interface [polypeptide binding]; other site 693982006667 conserved gate region; other site 693982006668 putative PBP binding loops; other site 693982006669 ABC-ATPase subunit interface; other site 693982006670 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693982006671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982006672 dimer interface [polypeptide binding]; other site 693982006673 conserved gate region; other site 693982006674 putative PBP binding loops; other site 693982006675 ABC-ATPase subunit interface; other site 693982006676 NMT1/THI5 like; Region: NMT1; pfam09084 693982006677 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693982006678 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982006679 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982006680 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693982006681 Protein export membrane protein; Region: SecD_SecF; cl14618 693982006682 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693982006683 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 693982006684 UreF; Region: UreF; pfam01730 693982006685 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 693982006686 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 693982006687 dimer interface [polypeptide binding]; other site 693982006688 catalytic residues [active] 693982006689 Uncharacterized conserved protein [Function unknown]; Region: COG1359 693982006690 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 693982006691 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 693982006692 catalytic triad [active] 693982006693 dimer interface [polypeptide binding]; other site 693982006694 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 693982006695 Predicted transcriptional regulator [Transcription]; Region: COG2944 693982006696 urease subunit alpha; Reviewed; Region: ureC; PRK13207 693982006697 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 693982006698 subunit interactions [polypeptide binding]; other site 693982006699 active site 693982006700 flap region; other site 693982006701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 693982006702 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 693982006703 alpha-beta subunit interface [polypeptide binding]; other site 693982006704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 693982006705 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 693982006706 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 693982006707 alpha-gamma subunit interface [polypeptide binding]; other site 693982006708 beta-gamma subunit interface [polypeptide binding]; other site 693982006709 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 693982006710 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693982006711 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 693982006712 dimerization interface [polypeptide binding]; other site 693982006713 ligand binding site [chemical binding]; other site 693982006714 NADP binding site [chemical binding]; other site 693982006715 catalytic site [active] 693982006716 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693982006717 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693982006718 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693982006719 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693982006720 MarR family; Region: MarR; pfam01047 693982006721 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 693982006722 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 693982006723 dimerization interface [polypeptide binding]; other site 693982006724 ligand binding site [chemical binding]; other site 693982006725 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 693982006726 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 693982006727 Walker A/P-loop; other site 693982006728 ATP binding site [chemical binding]; other site 693982006729 Q-loop/lid; other site 693982006730 ABC transporter signature motif; other site 693982006731 Walker B; other site 693982006732 D-loop; other site 693982006733 H-loop/switch region; other site 693982006734 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 693982006735 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 693982006736 Walker A/P-loop; other site 693982006737 ATP binding site [chemical binding]; other site 693982006738 Q-loop/lid; other site 693982006739 ABC transporter signature motif; other site 693982006740 Walker B; other site 693982006741 D-loop; other site 693982006742 H-loop/switch region; other site 693982006743 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 693982006744 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 693982006745 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 693982006746 TM-ABC transporter signature motif; other site 693982006747 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982006748 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 693982006749 TM-ABC transporter signature motif; other site 693982006750 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 693982006751 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693982006752 active site 693982006753 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693982006754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 693982006755 active site 693982006756 phosphorylation site [posttranslational modification] 693982006757 intermolecular recognition site; other site 693982006758 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693982006759 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693982006760 ligand binding site [chemical binding]; other site 693982006761 flexible hinge region; other site 693982006762 putative switch regulator; other site 693982006763 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 693982006764 non-specific DNA interactions [nucleotide binding]; other site 693982006765 DNA binding site [nucleotide binding] 693982006766 sequence specific DNA binding site [nucleotide binding]; other site 693982006767 putative cAMP binding site [chemical binding]; other site 693982006768 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 693982006769 classical (c) SDRs; Region: SDR_c; cd05233 693982006770 NAD(P) binding site [chemical binding]; other site 693982006771 active site 693982006772 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 693982006773 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982006774 Zn binding site [ion binding]; other site 693982006775 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 693982006776 Zn binding site [ion binding]; other site 693982006777 Predicted esterase [General function prediction only]; Region: COG0400 693982006778 putative hydrolase; Provisional; Region: PRK11460 693982006779 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 693982006780 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693982006781 Predicted flavoprotein [General function prediction only]; Region: COG0431 693982006782 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 693982006783 Zn binding site [ion binding]; other site 693982006784 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 693982006785 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982006786 Zn binding site [ion binding]; other site 693982006787 Predicted amidohydrolase [General function prediction only]; Region: COG0388 693982006788 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 693982006789 putative active site [active] 693982006790 catalytic triad [active] 693982006791 putative dimer interface [polypeptide binding]; other site 693982006792 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982006793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982006794 dimer interface [polypeptide binding]; other site 693982006795 conserved gate region; other site 693982006796 putative PBP binding loops; other site 693982006797 ABC-ATPase subunit interface; other site 693982006798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982006799 putative PBP binding loops; other site 693982006800 ABC-ATPase subunit interface; other site 693982006801 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693982006802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982006803 Walker A/P-loop; other site 693982006804 ATP binding site [chemical binding]; other site 693982006805 Q-loop/lid; other site 693982006806 ABC transporter signature motif; other site 693982006807 Walker B; other site 693982006808 D-loop; other site 693982006809 H-loop/switch region; other site 693982006810 TOBE domain; Region: TOBE_2; pfam08402 693982006811 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 693982006812 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693982006813 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 693982006814 agmatinase; Region: agmatinase; TIGR01230 693982006815 oligomer interface [polypeptide binding]; other site 693982006816 putative active site [active] 693982006817 Mn binding site [ion binding]; other site 693982006818 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693982006819 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982006820 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693982006821 dimerization interface [polypeptide binding]; other site 693982006822 substrate binding pocket [chemical binding]; other site 693982006823 hypothetical protein; Provisional; Region: PRK07550 693982006824 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982006825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982006826 homodimer interface [polypeptide binding]; other site 693982006827 catalytic residue [active] 693982006828 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 693982006829 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693982006830 NAD binding site [chemical binding]; other site 693982006831 catalytic residues [active] 693982006832 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693982006833 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982006834 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 693982006835 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693982006836 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982006837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982006838 DNA-binding site [nucleotide binding]; DNA binding site 693982006839 FCD domain; Region: FCD; pfam07729 693982006840 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982006841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982006842 DNA-binding site [nucleotide binding]; DNA binding site 693982006843 FCD domain; Region: FCD; pfam07729 693982006844 hypothetical protein; Provisional; Region: PRK05968 693982006845 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693982006846 homodimer interface [polypeptide binding]; other site 693982006847 substrate-cofactor binding pocket; other site 693982006848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982006849 catalytic residue [active] 693982006850 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982006851 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982006852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982006853 dimer interface [polypeptide binding]; other site 693982006854 conserved gate region; other site 693982006855 putative PBP binding loops; other site 693982006856 ABC-ATPase subunit interface; other site 693982006857 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982006858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982006859 dimer interface [polypeptide binding]; other site 693982006860 conserved gate region; other site 693982006861 putative PBP binding loops; other site 693982006862 ABC-ATPase subunit interface; other site 693982006863 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982006864 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982006865 Walker A/P-loop; other site 693982006866 ATP binding site [chemical binding]; other site 693982006867 Q-loop/lid; other site 693982006868 ABC transporter signature motif; other site 693982006869 Walker B; other site 693982006870 D-loop; other site 693982006871 H-loop/switch region; other site 693982006872 TOBE domain; Region: TOBE_2; pfam08402 693982006873 Cytochrome c2 [Energy production and conversion]; Region: COG3474 693982006874 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 693982006875 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 693982006876 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 693982006877 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 693982006878 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 693982006879 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 693982006880 Subunit I/III interface [polypeptide binding]; other site 693982006881 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 693982006882 Subunit I/III interface [polypeptide binding]; other site 693982006883 Predicted small integral membrane protein [Function unknown]; Region: COG5605 693982006884 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982006885 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693982006886 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 693982006887 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693982006888 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 693982006889 active site 693982006890 metal binding site [ion binding]; metal-binding site 693982006891 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982006892 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 693982006893 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982006894 short chain dehydrogenase; Provisional; Region: PRK07060 693982006895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982006896 NAD(P) binding site [chemical binding]; other site 693982006897 active site 693982006898 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693982006899 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 693982006900 inhibitor binding site; inhibition site 693982006901 catalytic Zn binding site [ion binding]; other site 693982006902 structural Zn binding site [ion binding]; other site 693982006903 NADP binding site [chemical binding]; other site 693982006904 tetramer interface [polypeptide binding]; other site 693982006905 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 693982006906 [2Fe-2S] cluster binding site [ion binding]; other site 693982006907 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 693982006908 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982006909 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 693982006910 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 693982006911 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982006912 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982006913 TM-ABC transporter signature motif; other site 693982006914 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 693982006915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982006916 Walker A/P-loop; other site 693982006917 ATP binding site [chemical binding]; other site 693982006918 Q-loop/lid; other site 693982006919 ABC transporter signature motif; other site 693982006920 Walker B; other site 693982006921 D-loop; other site 693982006922 H-loop/switch region; other site 693982006923 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 693982006924 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693982006925 putative ligand binding site [chemical binding]; other site 693982006926 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693982006927 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 693982006928 putative metal binding site [ion binding]; other site 693982006929 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982006930 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 693982006931 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 693982006932 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 693982006933 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 693982006934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982006935 dimer interface [polypeptide binding]; other site 693982006936 conserved gate region; other site 693982006937 putative PBP binding loops; other site 693982006938 ABC-ATPase subunit interface; other site 693982006939 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982006940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693982006941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982006942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982006943 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 693982006944 putative dimerization interface [polypeptide binding]; other site 693982006945 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982006946 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982006947 TM-ABC transporter signature motif; other site 693982006948 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982006949 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982006950 Walker A/P-loop; other site 693982006951 ATP binding site [chemical binding]; other site 693982006952 Q-loop/lid; other site 693982006953 ABC transporter signature motif; other site 693982006954 Walker B; other site 693982006955 D-loop; other site 693982006956 H-loop/switch region; other site 693982006957 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982006958 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982006959 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 693982006960 ligand binding site [chemical binding]; other site 693982006961 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 693982006962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982006963 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693982006964 NAD(P) binding site [chemical binding]; other site 693982006965 active site 693982006966 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 693982006967 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982006968 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982006969 DNA-binding site [nucleotide binding]; DNA binding site 693982006970 FCD domain; Region: FCD; pfam07729 693982006971 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 693982006972 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 693982006973 dimer interface [polypeptide binding]; other site 693982006974 active site 693982006975 metal binding site [ion binding]; metal-binding site 693982006976 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 693982006977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982006978 NAD(P) binding site [chemical binding]; other site 693982006979 active site 693982006980 short chain dehydrogenase; Provisional; Region: PRK06841 693982006981 classical (c) SDRs; Region: SDR_c; cd05233 693982006982 NAD(P) binding site [chemical binding]; other site 693982006983 active site 693982006984 glucose-6-phosphate isomerase; Provisional; Region: PRK04190 693982006985 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 693982006986 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 693982006987 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 693982006988 active site 693982006989 intersubunit interface [polypeptide binding]; other site 693982006990 catalytic residue [active] 693982006991 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 693982006992 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 693982006993 NAD(P) binding pocket [chemical binding]; other site 693982006994 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 693982006995 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693982006996 putative ligand binding site [chemical binding]; other site 693982006997 putative NAD binding site [chemical binding]; other site 693982006998 catalytic site [active] 693982006999 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 693982007000 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 693982007001 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 693982007002 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693982007003 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693982007004 putative active site [active] 693982007005 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 693982007006 intersubunit interface [polypeptide binding]; other site 693982007007 active site 693982007008 catalytic residue [active] 693982007009 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 693982007010 D-xylulose kinases, subgroup 3; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_3; cd07811 693982007011 putative N- and C-terminal domain interface [polypeptide binding]; other site 693982007012 putative active site [active] 693982007013 putative MgATP binding site [chemical binding]; other site 693982007014 catalytic site [active] 693982007015 metal binding site [ion binding]; metal-binding site 693982007016 putative xylulose binding site [chemical binding]; other site 693982007017 putative homodimer interface [polypeptide binding]; other site 693982007018 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 693982007019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982007020 NAD(P) binding site [chemical binding]; other site 693982007021 active site 693982007022 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982007023 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982007024 TM-ABC transporter signature motif; other site 693982007025 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982007026 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982007027 Walker A/P-loop; other site 693982007028 ATP binding site [chemical binding]; other site 693982007029 Q-loop/lid; other site 693982007030 ABC transporter signature motif; other site 693982007031 Walker B; other site 693982007032 D-loop; other site 693982007033 H-loop/switch region; other site 693982007034 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982007035 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982007036 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 693982007037 putative ligand binding site [chemical binding]; other site 693982007038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982007039 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693982007040 NAD(P) binding site [chemical binding]; other site 693982007041 active site 693982007042 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693982007043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982007044 DNA-binding site [nucleotide binding]; DNA binding site 693982007045 UTRA domain; Region: UTRA; pfam07702 693982007046 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 693982007047 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 693982007048 N- and C-terminal domain interface [polypeptide binding]; other site 693982007049 active site 693982007050 MgATP binding site [chemical binding]; other site 693982007051 catalytic site [active] 693982007052 metal binding site [ion binding]; metal-binding site 693982007053 xylulose binding site [chemical binding]; other site 693982007054 homodimer interface [polypeptide binding]; other site 693982007055 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 693982007056 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 693982007057 TPP-binding site [chemical binding]; other site 693982007058 dimer interface [polypeptide binding]; other site 693982007059 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693982007060 PYR/PP interface [polypeptide binding]; other site 693982007061 dimer interface [polypeptide binding]; other site 693982007062 TPP binding site [chemical binding]; other site 693982007063 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693982007064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982007065 putative transporter; Provisional; Region: PRK10504 693982007066 putative substrate translocation pore; other site 693982007067 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 693982007068 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982007069 substrate binding pocket [chemical binding]; other site 693982007070 membrane-bound complex binding site; other site 693982007071 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693982007072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982007073 dimer interface [polypeptide binding]; other site 693982007074 conserved gate region; other site 693982007075 putative PBP binding loops; other site 693982007076 ABC-ATPase subunit interface; other site 693982007077 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 693982007078 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693982007079 Walker A/P-loop; other site 693982007080 ATP binding site [chemical binding]; other site 693982007081 Q-loop/lid; other site 693982007082 ABC transporter signature motif; other site 693982007083 Walker B; other site 693982007084 D-loop; other site 693982007085 H-loop/switch region; other site 693982007086 Ferredoxin [Energy production and conversion]; Region: COG1146 693982007087 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 693982007088 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 693982007089 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693982007090 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 693982007091 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693982007092 putative catalytic residue [active] 693982007093 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 693982007094 apolar tunnel; other site 693982007095 heme binding site [chemical binding]; other site 693982007096 dimerization interface [polypeptide binding]; other site 693982007097 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 693982007098 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693982007099 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693982007100 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693982007101 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693982007102 putative active site [active] 693982007103 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 693982007104 Isochorismatase family; Region: Isochorismatase; pfam00857 693982007105 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 693982007106 catalytic triad [active] 693982007107 conserved cis-peptide bond; other site 693982007108 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 693982007109 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693982007110 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 693982007111 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 693982007112 Walker A/P-loop; other site 693982007113 ATP binding site [chemical binding]; other site 693982007114 Q-loop/lid; other site 693982007115 ABC transporter signature motif; other site 693982007116 Walker B; other site 693982007117 D-loop; other site 693982007118 H-loop/switch region; other site 693982007119 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 693982007120 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 693982007121 Walker A/P-loop; other site 693982007122 ATP binding site [chemical binding]; other site 693982007123 Q-loop/lid; other site 693982007124 ABC transporter signature motif; other site 693982007125 Walker B; other site 693982007126 D-loop; other site 693982007127 H-loop/switch region; other site 693982007128 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 693982007129 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982007130 TM-ABC transporter signature motif; other site 693982007131 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 693982007132 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 693982007133 TM-ABC transporter signature motif; other site 693982007134 Isochorismatase family; Region: Isochorismatase; pfam00857 693982007135 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 693982007136 catalytic triad [active] 693982007137 conserved cis-peptide bond; other site 693982007138 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 693982007139 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693982007140 inhibitor-cofactor binding pocket; inhibition site 693982007141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982007142 catalytic residue [active] 693982007143 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 693982007144 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693982007145 active site 693982007146 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 693982007147 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982007148 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 693982007149 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693982007150 active site 693982007151 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982007152 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 693982007153 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982007154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982007155 dimer interface [polypeptide binding]; other site 693982007156 conserved gate region; other site 693982007157 putative PBP binding loops; other site 693982007158 ABC-ATPase subunit interface; other site 693982007159 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 693982007160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982007161 dimer interface [polypeptide binding]; other site 693982007162 conserved gate region; other site 693982007163 putative PBP binding loops; other site 693982007164 ABC-ATPase subunit interface; other site 693982007165 cytosine deaminase; Provisional; Region: PRK05985 693982007166 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 693982007167 active site 693982007168 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 693982007169 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693982007170 active site 693982007171 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 693982007172 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982007173 Walker A/P-loop; other site 693982007174 ATP binding site [chemical binding]; other site 693982007175 Q-loop/lid; other site 693982007176 ABC transporter signature motif; other site 693982007177 Walker B; other site 693982007178 D-loop; other site 693982007179 H-loop/switch region; other site 693982007180 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982007181 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 693982007182 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982007183 Walker A/P-loop; other site 693982007184 ATP binding site [chemical binding]; other site 693982007185 Q-loop/lid; other site 693982007186 ABC transporter signature motif; other site 693982007187 Walker B; other site 693982007188 D-loop; other site 693982007189 H-loop/switch region; other site 693982007190 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 693982007191 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 693982007192 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982007193 DNA-binding site [nucleotide binding]; DNA binding site 693982007194 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693982007195 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 693982007196 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 693982007197 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982007198 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693982007199 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 693982007200 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 693982007201 [2Fe-2S] cluster binding site [ion binding]; other site 693982007202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982007203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982007204 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 693982007205 putative effector binding pocket; other site 693982007206 putative dimerization interface [polypeptide binding]; other site 693982007207 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982007208 Transposase domain (DUF772); Region: DUF772; pfam05598 693982007209 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982007210 Integrase core domain; Region: rve; pfam00665 693982007211 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 693982007212 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693982007213 Peptidase family M23; Region: Peptidase_M23; pfam01551 693982007214 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 693982007215 Clp amino terminal domain; Region: Clp_N; pfam02861 693982007216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982007217 Walker A motif; other site 693982007218 ATP binding site [chemical binding]; other site 693982007219 Walker B motif; other site 693982007220 arginine finger; other site 693982007221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982007222 Walker A motif; other site 693982007223 ATP binding site [chemical binding]; other site 693982007224 Walker B motif; other site 693982007225 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 693982007226 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 693982007227 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 693982007228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982007229 S-adenosylmethionine binding site [chemical binding]; other site 693982007230 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 693982007231 peptide chain release factor 1; Validated; Region: prfA; PRK00591 693982007232 This domain is found in peptide chain release factors; Region: PCRF; smart00937 693982007233 RF-1 domain; Region: RF-1; pfam00472 693982007234 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 693982007235 GAF domain; Region: GAF; pfam01590 693982007236 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 693982007237 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693982007238 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693982007239 aspartate kinase; Reviewed; Region: PRK06635 693982007240 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 693982007241 putative nucleotide binding site [chemical binding]; other site 693982007242 putative catalytic residues [active] 693982007243 putative Mg ion binding site [ion binding]; other site 693982007244 putative aspartate binding site [chemical binding]; other site 693982007245 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 693982007246 putative allosteric regulatory site; other site 693982007247 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 693982007248 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 693982007249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982007250 S-adenosylmethionine binding site [chemical binding]; other site 693982007251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 693982007252 Predicted amidohydrolase [General function prediction only]; Region: COG0388 693982007253 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 693982007254 putative active site [active] 693982007255 catalytic triad [active] 693982007256 dimer interface [polypeptide binding]; other site 693982007257 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 693982007258 GSH binding site [chemical binding]; other site 693982007259 catalytic residues [active] 693982007260 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 693982007261 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 693982007262 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 693982007263 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 693982007264 active site 693982007265 8-oxo-dGMP binding site [chemical binding]; other site 693982007266 nudix motif; other site 693982007267 metal binding site [ion binding]; metal-binding site 693982007268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982007269 Coenzyme A binding pocket [chemical binding]; other site 693982007270 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 693982007271 heterotetramer interface [polypeptide binding]; other site 693982007272 active site pocket [active] 693982007273 cleavage site 693982007274 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 693982007275 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 693982007276 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 693982007277 SEC-C motif; Region: SEC-C; pfam02810 693982007278 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 693982007279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982007280 putative substrate translocation pore; other site 693982007281 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 693982007282 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693982007283 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 693982007284 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 693982007285 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 693982007286 active site 693982007287 acyl-activating enzyme (AAE) consensus motif; other site 693982007288 putative CoA binding site [chemical binding]; other site 693982007289 AMP binding site [chemical binding]; other site 693982007290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 693982007291 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 693982007292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982007293 Coenzyme A binding pocket [chemical binding]; other site 693982007294 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 693982007295 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 693982007296 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693982007297 active site 693982007298 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 693982007299 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693982007300 minor groove reading motif; other site 693982007301 helix-hairpin-helix signature motif; other site 693982007302 substrate binding pocket [chemical binding]; other site 693982007303 active site 693982007304 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 693982007305 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 693982007306 active site 693982007307 HIGH motif; other site 693982007308 nucleotide binding site [chemical binding]; other site 693982007309 active site 693982007310 KMSKS motif; other site 693982007311 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 693982007312 short chain dehydrogenase; Provisional; Region: PRK05993 693982007313 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 693982007314 NADP binding site [chemical binding]; other site 693982007315 active site 693982007316 steroid binding site; other site 693982007317 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 693982007318 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 693982007319 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 693982007320 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 693982007321 Ligand binding site [chemical binding]; other site 693982007322 Electron transfer flavoprotein domain; Region: ETF; pfam01012 693982007323 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 693982007324 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 693982007325 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 693982007326 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 693982007327 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693982007328 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693982007329 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693982007330 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693982007331 catalytic residues [active] 693982007332 argininosuccinate lyase; Provisional; Region: PRK00855 693982007333 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 693982007334 active sites [active] 693982007335 tetramer interface [polypeptide binding]; other site 693982007336 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 693982007337 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 693982007338 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 693982007339 active site 693982007340 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693982007341 substrate binding site [chemical binding]; other site 693982007342 catalytic residues [active] 693982007343 dimer interface [polypeptide binding]; other site 693982007344 TIGR02302 family protein; Region: aProt_lowcomp 693982007345 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 693982007346 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 693982007347 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982007348 Response regulator receiver domain; Region: Response_reg; pfam00072 693982007349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982007350 active site 693982007351 phosphorylation site [posttranslational modification] 693982007352 intermolecular recognition site; other site 693982007353 dimerization interface [polypeptide binding]; other site 693982007354 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693982007355 active site 693982007356 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 693982007357 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693982007358 Walker A/P-loop; other site 693982007359 ATP binding site [chemical binding]; other site 693982007360 Q-loop/lid; other site 693982007361 ABC transporter signature motif; other site 693982007362 Walker B; other site 693982007363 D-loop; other site 693982007364 H-loop/switch region; other site 693982007365 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 693982007366 Uncharacterized conserved protein [Function unknown]; Region: COG1434 693982007367 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693982007368 putative active site [active] 693982007369 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693982007370 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693982007371 putative acyl-acceptor binding pocket; other site 693982007372 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 693982007373 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 693982007374 putative active site pocket [active] 693982007375 dimerization interface [polypeptide binding]; other site 693982007376 putative catalytic residue [active] 693982007377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 693982007378 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 693982007379 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 693982007380 prephenate dehydrogenase; Validated; Region: PRK08507 693982007381 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 693982007382 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982007383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982007384 homodimer interface [polypeptide binding]; other site 693982007385 catalytic residue [active] 693982007386 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693982007387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982007388 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 693982007389 Uncharacterized conserved protein [Function unknown]; Region: COG3542 693982007390 aromatic amino acid exporter; Provisional; Region: PRK11689 693982007391 EamA-like transporter family; Region: EamA; pfam00892 693982007392 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 693982007393 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 693982007394 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 693982007395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 693982007396 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 693982007397 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 693982007398 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 693982007399 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 693982007400 metal ion-dependent adhesion site (MIDAS); other site 693982007401 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 693982007402 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 693982007403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 693982007404 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 693982007405 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693982007406 HSP70 interaction site [polypeptide binding]; other site 693982007407 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 693982007408 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 693982007409 Domain of unknown function DUF21; Region: DUF21; pfam01595 693982007410 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693982007411 Transporter associated domain; Region: CorC_HlyC; smart01091 693982007412 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 693982007413 active site 693982007414 dimer interface [polypeptide binding]; other site 693982007415 metal binding site [ion binding]; metal-binding site 693982007416 shikimate kinase; Provisional; Region: PRK13946 693982007417 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 693982007418 ADP binding site [chemical binding]; other site 693982007419 magnesium binding site [ion binding]; other site 693982007420 putative shikimate binding site; other site 693982007421 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 693982007422 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 693982007423 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 693982007424 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693982007425 active site 693982007426 DNA binding site [nucleotide binding] 693982007427 Int/Topo IB signature motif; other site 693982007428 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 693982007429 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 693982007430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 693982007431 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 693982007432 CPxP motif; other site 693982007433 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 693982007434 oligomeric interface; other site 693982007435 putative active site [active] 693982007436 homodimer interface [polypeptide binding]; other site 693982007437 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 693982007438 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 693982007439 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693982007440 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 693982007441 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 693982007442 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 693982007443 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693982007444 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 693982007445 metal binding site [ion binding]; metal-binding site 693982007446 putative dimer interface [polypeptide binding]; other site 693982007447 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982007448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982007449 putative DNA binding site [nucleotide binding]; other site 693982007450 putative Zn2+ binding site [ion binding]; other site 693982007451 AsnC family; Region: AsnC_trans_reg; pfam01037 693982007452 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 693982007453 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 693982007454 putative NAD(P) binding site [chemical binding]; other site 693982007455 putative substrate binding site [chemical binding]; other site 693982007456 catalytic Zn binding site [ion binding]; other site 693982007457 structural Zn binding site [ion binding]; other site 693982007458 dimer interface [polypeptide binding]; other site 693982007459 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 693982007460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982007461 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693982007462 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982007463 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 693982007464 putative DNA binding site [nucleotide binding]; other site 693982007465 putative Zn2+ binding site [ion binding]; other site 693982007466 AsnC family; Region: AsnC_trans_reg; pfam01037 693982007467 hypothetical protein; Provisional; Region: PRK06148 693982007468 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 693982007469 active site 693982007470 ATP binding site [chemical binding]; other site 693982007471 Peptidase family M23; Region: Peptidase_M23; pfam01551 693982007472 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693982007473 inhibitor-cofactor binding pocket; inhibition site 693982007474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982007475 catalytic residue [active] 693982007476 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 693982007477 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982007478 substrate binding pocket [chemical binding]; other site 693982007479 membrane-bound complex binding site; other site 693982007480 hinge residues; other site 693982007481 hypothetical protein; Provisional; Region: PRK06149 693982007482 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 693982007483 active site 693982007484 substrate binding site [chemical binding]; other site 693982007485 ATP binding site [chemical binding]; other site 693982007486 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693982007487 inhibitor-cofactor binding pocket; inhibition site 693982007488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982007489 catalytic residue [active] 693982007490 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 693982007491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982007492 DNA-binding site [nucleotide binding]; DNA binding site 693982007493 UTRA domain; Region: UTRA; pfam07702 693982007494 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 693982007495 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 693982007496 active site 693982007497 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 693982007498 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 693982007499 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 693982007500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982007501 dimer interface [polypeptide binding]; other site 693982007502 conserved gate region; other site 693982007503 ABC-ATPase subunit interface; other site 693982007504 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693982007505 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 693982007506 Walker A/P-loop; other site 693982007507 ATP binding site [chemical binding]; other site 693982007508 Q-loop/lid; other site 693982007509 ABC transporter signature motif; other site 693982007510 Walker B; other site 693982007511 D-loop; other site 693982007512 H-loop/switch region; other site 693982007513 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 693982007514 active sites [active] 693982007515 tetramer interface [polypeptide binding]; other site 693982007516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 693982007517 Nucleoside recognition; Region: Gate; pfam07670 693982007518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 693982007519 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 693982007520 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 693982007521 Ligand Binding Site [chemical binding]; other site 693982007522 Autoinducer binding domain; Region: Autoind_bind; pfam03472 693982007523 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982007524 DNA binding residues [nucleotide binding] 693982007525 dimerization interface [polypeptide binding]; other site 693982007526 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 693982007527 Predicted acetyltransferase [General function prediction only]; Region: COG2388 693982007528 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982007529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982007530 active site 693982007531 phosphorylation site [posttranslational modification] 693982007532 intermolecular recognition site; other site 693982007533 dimerization interface [polypeptide binding]; other site 693982007534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982007535 DNA binding site [nucleotide binding] 693982007536 Response regulator receiver domain; Region: Response_reg; pfam00072 693982007537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982007538 active site 693982007539 phosphorylation site [posttranslational modification] 693982007540 intermolecular recognition site; other site 693982007541 dimerization interface [polypeptide binding]; other site 693982007542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 693982007543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400 693982007544 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 693982007545 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 693982007546 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693982007547 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693982007548 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693982007549 RNA binding surface [nucleotide binding]; other site 693982007550 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693982007551 active site 693982007552 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 693982007553 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 693982007554 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982007555 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982007556 DNA binding residues [nucleotide binding] 693982007557 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 693982007558 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 693982007559 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 693982007560 GDP-binding site [chemical binding]; other site 693982007561 ACT binding site; other site 693982007562 IMP binding site; other site 693982007563 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693982007564 EamA-like transporter family; Region: EamA; pfam00892 693982007565 EamA-like transporter family; Region: EamA; pfam00892 693982007566 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 693982007567 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 693982007568 ligand binding site [chemical binding]; other site 693982007569 NAD binding site [chemical binding]; other site 693982007570 dimerization interface [polypeptide binding]; other site 693982007571 catalytic site [active] 693982007572 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 693982007573 putative L-serine binding site [chemical binding]; other site 693982007574 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 693982007575 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693982007576 catalytic residue [active] 693982007577 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 693982007578 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 693982007579 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 693982007580 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 693982007581 active site 693982007582 substrate binding site [chemical binding]; other site 693982007583 metal binding site [ion binding]; metal-binding site 693982007584 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 693982007585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982007586 Walker A motif; other site 693982007587 ATP binding site [chemical binding]; other site 693982007588 Walker B motif; other site 693982007589 arginine finger; other site 693982007590 Peptidase family M41; Region: Peptidase_M41; pfam01434 693982007591 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 693982007592 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 693982007593 Ligand Binding Site [chemical binding]; other site 693982007594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982007595 binding surface 693982007596 Tetratricopeptide repeat; Region: TPR_16; pfam13432 693982007597 TPR motif; other site 693982007598 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693982007599 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693982007600 ligand binding site [chemical binding]; other site 693982007601 translocation protein TolB; Provisional; Region: tolB; PRK05137 693982007602 TolB amino-terminal domain; Region: TolB_N; pfam04052 693982007603 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693982007604 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693982007605 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693982007606 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693982007607 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 693982007608 TolR protein; Region: tolR; TIGR02801 693982007609 TolQ protein; Region: tolQ; TIGR02796 693982007610 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 693982007611 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 693982007612 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 693982007613 active site 693982007614 DNA binding site [nucleotide binding] 693982007615 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 693982007616 DNA binding site [nucleotide binding] 693982007617 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 693982007618 nucleotide binding site [chemical binding]; other site 693982007619 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693982007620 active site 693982007621 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 693982007622 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982007623 NAD binding site [chemical binding]; other site 693982007624 substrate binding site [chemical binding]; other site 693982007625 active site 693982007626 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 693982007627 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 693982007628 substrate binding site; other site 693982007629 Manganese binding site; other site 693982007630 dimer interface; other site 693982007631 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982007632 extended (e) SDRs; Region: SDR_e; cd08946 693982007633 NAD(P) binding site [chemical binding]; other site 693982007634 active site 693982007635 substrate binding site [chemical binding]; other site 693982007636 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 693982007637 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693982007638 putative active site [active] 693982007639 putative metal binding site [ion binding]; other site 693982007640 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 693982007641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982007642 Walker A motif; other site 693982007643 ATP binding site [chemical binding]; other site 693982007644 Walker B motif; other site 693982007645 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 693982007646 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 693982007647 RuvA N terminal domain; Region: RuvA_N; pfam01330 693982007648 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 693982007649 active site 693982007650 putative DNA-binding cleft [nucleotide binding]; other site 693982007651 dimer interface [polypeptide binding]; other site 693982007652 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 693982007653 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 693982007654 hypothetical protein; Validated; Region: PRK00110 693982007655 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 693982007656 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 693982007657 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693982007658 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693982007659 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982007660 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982007661 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 693982007662 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693982007663 putative active site [active] 693982007664 metal binding site [ion binding]; metal-binding site 693982007665 homodimer binding site [polypeptide binding]; other site 693982007666 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 693982007667 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 693982007668 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982007669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982007670 LysR substrate binding domain; Region: LysR_substrate; pfam03466 693982007671 dimerization interface [polypeptide binding]; other site 693982007672 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 693982007673 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 693982007674 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 693982007675 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 693982007676 TPP-binding site [chemical binding]; other site 693982007677 dimer interface [polypeptide binding]; other site 693982007678 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693982007679 PYR/PP interface [polypeptide binding]; other site 693982007680 dimer interface [polypeptide binding]; other site 693982007681 TPP binding site [chemical binding]; other site 693982007682 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693982007683 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 693982007684 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693982007685 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693982007686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 693982007687 Phosphoglycerate kinase; Region: PGK; pfam00162 693982007688 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 693982007689 substrate binding site [chemical binding]; other site 693982007690 hinge regions; other site 693982007691 ADP binding site [chemical binding]; other site 693982007692 catalytic site [active] 693982007693 Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: COG3588 693982007694 catalytic residue [active] 693982007695 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 693982007696 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982007697 cyclase homology domain; Region: CHD; cd07302 693982007698 nucleotidyl binding site; other site 693982007699 metal binding site [ion binding]; metal-binding site 693982007700 dimer interface [polypeptide binding]; other site 693982007701 Predicted integral membrane protein [Function unknown]; Region: COG5616 693982007702 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693982007703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982007704 TPR motif; other site 693982007705 TPR repeat; Region: TPR_11; pfam13414 693982007706 binding surface 693982007707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982007708 binding surface 693982007709 TPR motif; other site 693982007710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982007711 putative substrate translocation pore; other site 693982007712 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 693982007713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 693982007714 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 693982007715 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 693982007716 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693982007717 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 693982007718 Walker A/P-loop; other site 693982007719 ATP binding site [chemical binding]; other site 693982007720 Q-loop/lid; other site 693982007721 ABC transporter signature motif; other site 693982007722 Walker B; other site 693982007723 D-loop; other site 693982007724 H-loop/switch region; other site 693982007725 hypothetical protein; Validated; Region: PRK09039 693982007726 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693982007727 ligand binding site [chemical binding]; other site 693982007728 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693982007729 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 693982007730 active site 693982007731 dimerization interface [polypeptide binding]; other site 693982007732 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693982007733 Sel1-like repeats; Region: SEL1; smart00671 693982007734 Sel1-like repeats; Region: SEL1; smart00671 693982007735 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 693982007736 thiamine phosphate binding site [chemical binding]; other site 693982007737 active site 693982007738 pyrophosphate binding site [ion binding]; other site 693982007739 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693982007740 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982007741 dimerization interface [polypeptide binding]; other site 693982007742 putative DNA binding site [nucleotide binding]; other site 693982007743 putative Zn2+ binding site [ion binding]; other site 693982007744 Uncharacterized small protein [Function unknown]; Region: COG5570 693982007745 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 693982007746 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 693982007747 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 693982007748 ATP-grasp domain; Region: ATP-grasp; pfam02222 693982007749 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 693982007750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982007751 TPR repeat; Region: TPR_11; pfam13414 693982007752 binding surface 693982007753 TPR motif; other site 693982007754 pyruvate kinase; Provisional; Region: PRK06247 693982007755 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 693982007756 domain interfaces; other site 693982007757 active site 693982007758 Predicted integral membrane protein [Function unknown]; Region: COG5480 693982007759 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 693982007760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 693982007761 hypothetical protein; Provisional; Region: PRK13694 693982007762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 693982007763 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 693982007764 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693982007765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982007766 active site 693982007767 phosphorylation site [posttranslational modification] 693982007768 intermolecular recognition site; other site 693982007769 dimerization interface [polypeptide binding]; other site 693982007770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982007771 Walker A motif; other site 693982007772 ATP binding site [chemical binding]; other site 693982007773 Walker B motif; other site 693982007774 arginine finger; other site 693982007775 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693982007776 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 693982007777 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 693982007778 active site 693982007779 Zn binding site [ion binding]; other site 693982007780 aminodeoxychorismate synthase; Provisional; Region: PRK07508 693982007781 chorismate binding enzyme; Region: Chorismate_bind; cl10555 693982007782 hypothetical protein; Provisional; Region: PRK07546 693982007783 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 693982007784 substrate-cofactor binding pocket; other site 693982007785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982007786 catalytic residue [active] 693982007787 PAS fold; Region: PAS_7; pfam12860 693982007788 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693982007789 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982007790 metal binding site [ion binding]; metal-binding site 693982007791 active site 693982007792 I-site; other site 693982007793 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 693982007794 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 693982007795 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 693982007796 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 693982007797 active site 693982007798 metal binding site [ion binding]; metal-binding site 693982007799 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693982007800 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693982007801 ferrochelatase; Reviewed; Region: hemH; PRK00035 693982007802 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 693982007803 C-terminal domain interface [polypeptide binding]; other site 693982007804 active site 693982007805 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 693982007806 active site 693982007807 N-terminal domain interface [polypeptide binding]; other site 693982007808 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 693982007809 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 693982007810 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 693982007811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338 693982007812 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 693982007813 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 693982007814 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 693982007815 active site 693982007816 tetramer interface; other site 693982007817 Transglycosylase SLT domain; Region: SLT_2; pfam13406 693982007818 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693982007819 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693982007820 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982007821 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 693982007822 active site 693982007823 catalytic triad [active] 693982007824 oxyanion hole [active] 693982007825 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 693982007826 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 693982007827 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 693982007828 active site 693982007829 dimer interface [polypeptide binding]; other site 693982007830 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 693982007831 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 693982007832 active site 693982007833 FMN binding site [chemical binding]; other site 693982007834 substrate binding site [chemical binding]; other site 693982007835 3Fe-4S cluster binding site [ion binding]; other site 693982007836 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 693982007837 domain interface; other site 693982007838 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 693982007839 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 693982007840 tetramer interface [polypeptide binding]; other site 693982007841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982007842 catalytic residue [active] 693982007843 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 693982007844 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 693982007845 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 693982007846 Autoinducer binding domain; Region: Autoind_bind; pfam03472 693982007847 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982007848 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982007849 DNA binding residues [nucleotide binding] 693982007850 dimerization interface [polypeptide binding]; other site 693982007851 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 693982007852 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982007853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982007854 dimer interface [polypeptide binding]; other site 693982007855 conserved gate region; other site 693982007856 putative PBP binding loops; other site 693982007857 ABC-ATPase subunit interface; other site 693982007858 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 693982007859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982007860 dimer interface [polypeptide binding]; other site 693982007861 conserved gate region; other site 693982007862 putative PBP binding loops; other site 693982007863 ABC-ATPase subunit interface; other site 693982007864 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 693982007865 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982007866 Walker A/P-loop; other site 693982007867 ATP binding site [chemical binding]; other site 693982007868 Q-loop/lid; other site 693982007869 ABC transporter signature motif; other site 693982007870 Walker B; other site 693982007871 D-loop; other site 693982007872 H-loop/switch region; other site 693982007873 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982007874 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982007875 Walker A/P-loop; other site 693982007876 ATP binding site [chemical binding]; other site 693982007877 Q-loop/lid; other site 693982007878 ABC transporter signature motif; other site 693982007879 Walker B; other site 693982007880 D-loop; other site 693982007881 H-loop/switch region; other site 693982007882 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982007883 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 693982007884 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982007885 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 693982007886 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 693982007887 putative dimer interface [polypeptide binding]; other site 693982007888 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 693982007889 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693982007890 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693982007891 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 693982007892 active site 693982007893 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 693982007894 Response regulator receiver domain; Region: Response_reg; pfam00072 693982007895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982007896 active site 693982007897 phosphorylation site [posttranslational modification] 693982007898 intermolecular recognition site; other site 693982007899 dimerization interface [polypeptide binding]; other site 693982007900 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 693982007901 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693982007902 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 693982007903 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982007904 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 693982007905 Transposase [DNA replication, recombination, and repair]; Region: COG5433 693982007906 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 693982007907 pseudoazurin; Region: pseudoazurin; TIGR02375 693982007908 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693982007909 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693982007910 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 693982007911 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 693982007912 Moco binding site; other site 693982007913 metal coordination site [ion binding]; other site 693982007914 dimerization interface [polypeptide binding]; other site 693982007915 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 693982007916 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 693982007917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982007918 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982007919 DNA binding residues [nucleotide binding] 693982007920 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693982007921 MarR family; Region: MarR; pfam01047 693982007922 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 693982007923 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982007924 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 693982007925 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982007926 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 693982007927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982007928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982007929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982007930 dimerization interface [polypeptide binding]; other site 693982007931 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982007932 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982007933 active site 693982007934 catalytic tetrad [active] 693982007935 Uncharacterized conserved protein [Function unknown]; Region: COG2308 693982007936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 693982007937 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 693982007938 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 693982007939 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 693982007940 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 693982007941 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 693982007942 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 693982007943 metal ion-dependent adhesion site (MIDAS); other site 693982007944 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 693982007945 homodimer interface [polypeptide binding]; other site 693982007946 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 693982007947 active site pocket [active] 693982007948 glycogen branching enzyme; Provisional; Region: PRK05402 693982007949 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 693982007950 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 693982007951 active site 693982007952 catalytic site [active] 693982007953 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 693982007954 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 693982007955 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 693982007956 ligand binding site; other site 693982007957 oligomer interface; other site 693982007958 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 693982007959 dimer interface [polypeptide binding]; other site 693982007960 N-terminal domain interface [polypeptide binding]; other site 693982007961 sulfate 1 binding site; other site 693982007962 glycogen synthase; Provisional; Region: glgA; PRK00654 693982007963 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 693982007964 ADP-binding pocket [chemical binding]; other site 693982007965 homodimer interface [polypeptide binding]; other site 693982007966 phosphoglucomutase; Region: PLN02307 693982007967 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 693982007968 substrate binding site [chemical binding]; other site 693982007969 dimer interface [polypeptide binding]; other site 693982007970 active site 693982007971 metal binding site [ion binding]; metal-binding site 693982007972 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 693982007973 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 693982007974 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 693982007975 active site 693982007976 catalytic site [active] 693982007977 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 693982007978 putative active site [active] 693982007979 putative catalytic site [active] 693982007980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 693982007981 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 693982007982 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 693982007983 NAD binding site [chemical binding]; other site 693982007984 catalytic Zn binding site [ion binding]; other site 693982007985 substrate binding site [chemical binding]; other site 693982007986 structural Zn binding site [ion binding]; other site 693982007987 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 693982007988 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 693982007989 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 693982007990 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693982007991 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 693982007992 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 693982007993 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693982007994 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 693982007995 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 693982007996 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 693982007997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982007998 TPR motif; other site 693982007999 binding surface 693982008000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982008001 binding surface 693982008002 TPR motif; other site 693982008003 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982008004 binding surface 693982008005 TPR motif; other site 693982008006 Protein of unknown function (DUF992); Region: DUF992; pfam06186 693982008007 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982008008 cyclase homology domain; Region: CHD; cd07302 693982008009 nucleotidyl binding site; other site 693982008010 metal binding site [ion binding]; metal-binding site 693982008011 dimer interface [polypeptide binding]; other site 693982008012 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 693982008013 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 693982008014 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 693982008015 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 693982008016 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 693982008017 ligand binding site [chemical binding]; other site 693982008018 homodimer interface [polypeptide binding]; other site 693982008019 NAD(P) binding site [chemical binding]; other site 693982008020 trimer interface B [polypeptide binding]; other site 693982008021 trimer interface A [polypeptide binding]; other site 693982008022 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 693982008023 PAS domain; Region: PAS; smart00091 693982008024 PAS fold; Region: PAS_7; pfam12860 693982008025 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693982008026 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982008027 metal binding site [ion binding]; metal-binding site 693982008028 active site 693982008029 I-site; other site 693982008030 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693982008031 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 693982008032 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 693982008033 catalytic triad [active] 693982008034 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693982008035 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 693982008036 putative ligand binding site [chemical binding]; other site 693982008037 NAD binding site [chemical binding]; other site 693982008038 catalytic site [active] 693982008039 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982008040 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982008041 DNA binding site [nucleotide binding] 693982008042 domain linker motif; other site 693982008043 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 693982008044 putative dimerization interface [polypeptide binding]; other site 693982008045 putative ligand binding site [chemical binding]; other site 693982008046 MarR family; Region: MarR_2; cl17246 693982008047 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 693982008048 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 693982008049 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 693982008050 P-loop, Walker A motif; other site 693982008051 Base recognition motif; other site 693982008052 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 693982008053 FOG: WD40 repeat [General function prediction only]; Region: COG2319 693982008054 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 693982008055 structural tetrad; other site 693982008056 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693982008057 Predicted acetyltransferase [General function prediction only]; Region: COG3153 693982008058 Coenzyme A binding pocket [chemical binding]; other site 693982008059 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 693982008060 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 693982008061 dimer interface [polypeptide binding]; other site 693982008062 active site 693982008063 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693982008064 catalytic residues [active] 693982008065 substrate binding site [chemical binding]; other site 693982008066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982008067 LysR family transcriptional regulator; Provisional; Region: PRK14997 693982008068 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693982008069 putative effector binding pocket; other site 693982008070 dimerization interface [polypeptide binding]; other site 693982008071 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 693982008072 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 693982008073 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 693982008074 putative active site [active] 693982008075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 693982008076 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693982008077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693982008078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 693982008079 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 693982008080 putative metal binding site [ion binding]; other site 693982008081 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 693982008082 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 693982008083 active site 693982008084 intersubunit interface [polypeptide binding]; other site 693982008085 catalytic residue [active] 693982008086 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 693982008087 putative active site [active] 693982008088 putative metal binding residues [ion binding]; other site 693982008089 signature motif; other site 693982008090 putative dimer interface [polypeptide binding]; other site 693982008091 putative phosphate binding site [ion binding]; other site 693982008092 CHAD domain; Region: CHAD; pfam05235 693982008093 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 693982008094 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 693982008095 active site residue [active] 693982008096 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 693982008097 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 693982008098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982008099 dimer interface [polypeptide binding]; other site 693982008100 conserved gate region; other site 693982008101 ABC-ATPase subunit interface; other site 693982008102 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 693982008103 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 693982008104 Walker A/P-loop; other site 693982008105 ATP binding site [chemical binding]; other site 693982008106 Q-loop/lid; other site 693982008107 ABC transporter signature motif; other site 693982008108 Walker B; other site 693982008109 D-loop; other site 693982008110 H-loop/switch region; other site 693982008111 NIL domain; Region: NIL; pfam09383 693982008112 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 693982008113 beta-galactosidase; Region: BGL; TIGR03356 693982008114 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982008115 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982008116 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982008117 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693982008118 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 693982008119 xylose isomerase; Provisional; Region: PRK05474 693982008120 xylose isomerase; Region: xylose_isom_A; TIGR02630 693982008121 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 693982008122 N- and C-terminal domain interface [polypeptide binding]; other site 693982008123 D-xylulose kinase; Region: XylB; TIGR01312 693982008124 active site 693982008125 MgATP binding site [chemical binding]; other site 693982008126 catalytic site [active] 693982008127 metal binding site [ion binding]; metal-binding site 693982008128 xylulose binding site [chemical binding]; other site 693982008129 homodimer interface [polypeptide binding]; other site 693982008130 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982008131 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982008132 DNA binding site [nucleotide binding] 693982008133 domain linker motif; other site 693982008134 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 693982008135 putative ligand binding site [chemical binding]; other site 693982008136 Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion]; Region: COG5555 693982008137 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 693982008138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982008139 putative substrate translocation pore; other site 693982008140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982008141 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693982008142 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982008143 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982008144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982008145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982008146 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 693982008147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982008148 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693982008149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982008150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 693982008151 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 693982008152 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 693982008153 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 693982008154 HIGH motif; other site 693982008155 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 693982008156 active site 693982008157 KMSKS motif; other site 693982008158 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 693982008159 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 693982008160 dimer interface [polypeptide binding]; other site 693982008161 putative anticodon binding site; other site 693982008162 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 693982008163 motif 1; other site 693982008164 active site 693982008165 motif 2; other site 693982008166 motif 3; other site 693982008167 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 693982008168 active site 693982008169 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 693982008170 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693982008171 ATP-dependent DNA ligase; Validated; Region: PRK09247 693982008172 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 693982008173 active site 693982008174 DNA binding site [nucleotide binding] 693982008175 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 693982008176 DNA binding site [nucleotide binding] 693982008177 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3452 693982008178 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982008179 PAS fold; Region: PAS_3; pfam08447 693982008180 putative active site [active] 693982008181 heme pocket [chemical binding]; other site 693982008182 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693982008183 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982008184 metal binding site [ion binding]; metal-binding site 693982008185 active site 693982008186 I-site; other site 693982008187 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693982008188 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 693982008189 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 693982008190 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693982008191 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 693982008192 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 693982008193 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 693982008194 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 693982008195 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 693982008196 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693982008197 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 693982008198 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 693982008199 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 693982008200 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 693982008201 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693982008202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982008203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982008204 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693982008205 putative effector binding pocket; other site 693982008206 dimerization interface [polypeptide binding]; other site 693982008207 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 693982008208 active site 693982008209 SAM binding site [chemical binding]; other site 693982008210 homodimer interface [polypeptide binding]; other site 693982008211 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 693982008212 active site 693982008213 putative homodimer interface [polypeptide binding]; other site 693982008214 SAM binding site [chemical binding]; other site 693982008215 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 693982008216 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 693982008217 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 693982008218 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 693982008219 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 693982008220 active site 693982008221 SAM binding site [chemical binding]; other site 693982008222 homodimer interface [polypeptide binding]; other site 693982008223 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 693982008224 active site 693982008225 SAM binding site [chemical binding]; other site 693982008226 homodimer interface [polypeptide binding]; other site 693982008227 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 693982008228 Precorrin-8X methylmutase; Region: CbiC; pfam02570 693982008229 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 693982008230 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693982008231 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 693982008232 active site 693982008233 SAM binding site [chemical binding]; other site 693982008234 homodimer interface [polypeptide binding]; other site 693982008235 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 693982008236 ligand binding site [chemical binding]; other site 693982008237 active site 693982008238 UGI interface [polypeptide binding]; other site 693982008239 catalytic site [active] 693982008240 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 693982008241 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693982008242 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693982008243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982008244 dimer interface [polypeptide binding]; other site 693982008245 conserved gate region; other site 693982008246 putative PBP binding loops; other site 693982008247 ABC-ATPase subunit interface; other site 693982008248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982008249 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 693982008250 Walker A/P-loop; other site 693982008251 ATP binding site [chemical binding]; other site 693982008252 Q-loop/lid; other site 693982008253 ABC transporter signature motif; other site 693982008254 Walker B; other site 693982008255 D-loop; other site 693982008256 H-loop/switch region; other site 693982008257 TOBE domain; Region: TOBE; pfam03459 693982008258 Transposase domain (DUF772); Region: DUF772; pfam05598 693982008259 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693982008260 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 693982008261 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693982008262 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982008263 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 693982008264 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 693982008265 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 693982008266 tetramer interface [polypeptide binding]; other site 693982008267 TPP-binding site [chemical binding]; other site 693982008268 heterodimer interface [polypeptide binding]; other site 693982008269 phosphorylation loop region [posttranslational modification] 693982008270 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 693982008271 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 693982008272 alpha subunit interface [polypeptide binding]; other site 693982008273 TPP binding site [chemical binding]; other site 693982008274 heterodimer interface [polypeptide binding]; other site 693982008275 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693982008276 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 693982008277 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693982008278 E3 interaction surface; other site 693982008279 lipoyl attachment site [posttranslational modification]; other site 693982008280 e3 binding domain; Region: E3_binding; pfam02817 693982008281 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693982008282 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 693982008283 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693982008284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982008285 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693982008286 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 693982008287 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 693982008288 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 693982008289 putative active site [active] 693982008290 putative substrate binding site [chemical binding]; other site 693982008291 putative cosubstrate binding site; other site 693982008292 catalytic site [active] 693982008293 maleylacetoacetate isomerase; Region: maiA; TIGR01262 693982008294 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 693982008295 C-terminal domain interface [polypeptide binding]; other site 693982008296 GSH binding site (G-site) [chemical binding]; other site 693982008297 putative dimer interface [polypeptide binding]; other site 693982008298 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 693982008299 dimer interface [polypeptide binding]; other site 693982008300 N-terminal domain interface [polypeptide binding]; other site 693982008301 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 693982008302 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 693982008303 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693982008304 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 693982008305 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693982008306 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 693982008307 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982008308 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982008309 putative DNA binding site [nucleotide binding]; other site 693982008310 putative Zn2+ binding site [ion binding]; other site 693982008311 AsnC family; Region: AsnC_trans_reg; pfam01037 693982008312 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 693982008313 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 693982008314 dimer interface [polypeptide binding]; other site 693982008315 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 693982008316 active site 693982008317 Fe binding site [ion binding]; other site 693982008318 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982008319 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982008320 DNA binding residues [nucleotide binding] 693982008321 dimerization interface [polypeptide binding]; other site 693982008322 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 693982008323 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693982008324 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 693982008325 Walker A/P-loop; other site 693982008326 ATP binding site [chemical binding]; other site 693982008327 Q-loop/lid; other site 693982008328 ABC transporter signature motif; other site 693982008329 Walker B; other site 693982008330 D-loop; other site 693982008331 H-loop/switch region; other site 693982008332 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 693982008333 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982008334 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982008335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982008336 TPR motif; other site 693982008337 binding surface 693982008338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982008339 binding surface 693982008340 Tetratricopeptide repeat; Region: TPR_16; pfam13432 693982008341 TPR motif; other site 693982008342 Tetratricopeptide repeat; Region: TPR_16; pfam13432 693982008343 Methyltransferase domain; Region: Methyltransf_25; pfam13649 693982008344 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693982008345 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982008346 metal binding site [ion binding]; metal-binding site 693982008347 active site 693982008348 I-site; other site 693982008349 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693982008350 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693982008351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982008352 DNA-binding site [nucleotide binding]; DNA binding site 693982008353 UTRA domain; Region: UTRA; pfam07702 693982008354 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 693982008355 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 693982008356 putative active site [active] 693982008357 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 693982008358 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693982008359 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 693982008360 substrate binding site [chemical binding]; other site 693982008361 ATP binding site [chemical binding]; other site 693982008362 Predicted nucleic-acid-binding protein, contains PIN domain [General function prediction only]; Region: COG5573 693982008363 putative active site [active] 693982008364 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 693982008365 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693982008366 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693982008367 Walker A/P-loop; other site 693982008368 ATP binding site [chemical binding]; other site 693982008369 Q-loop/lid; other site 693982008370 ABC transporter signature motif; other site 693982008371 Walker B; other site 693982008372 D-loop; other site 693982008373 H-loop/switch region; other site 693982008374 EamA-like transporter family; Region: EamA; pfam00892 693982008375 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693982008376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982008377 dimer interface [polypeptide binding]; other site 693982008378 conserved gate region; other site 693982008379 putative PBP binding loops; other site 693982008380 ABC-ATPase subunit interface; other site 693982008381 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693982008382 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982008383 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693982008384 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982008385 substrate binding pocket [chemical binding]; other site 693982008386 membrane-bound complex binding site; other site 693982008387 hinge residues; other site 693982008388 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693982008389 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 693982008390 AP (apurinic/apyrimidinic) site pocket; other site 693982008391 DNA interaction; other site 693982008392 Metal-binding active site; metal-binding site 693982008393 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 693982008394 Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565 693982008395 active site 693982008396 catalytic site [active] 693982008397 metal binding site [ion binding]; metal-binding site 693982008398 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982008399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693982008400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982008401 dimer interface [polypeptide binding]; other site 693982008402 conserved gate region; other site 693982008403 putative PBP binding loops; other site 693982008404 ABC-ATPase subunit interface; other site 693982008405 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982008406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982008407 dimer interface [polypeptide binding]; other site 693982008408 conserved gate region; other site 693982008409 putative PBP binding loops; other site 693982008410 ABC-ATPase subunit interface; other site 693982008411 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 693982008412 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982008413 Walker A/P-loop; other site 693982008414 ATP binding site [chemical binding]; other site 693982008415 Q-loop/lid; other site 693982008416 ABC transporter signature motif; other site 693982008417 Walker B; other site 693982008418 D-loop; other site 693982008419 H-loop/switch region; other site 693982008420 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 693982008421 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 693982008422 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982008423 Walker A/P-loop; other site 693982008424 ATP binding site [chemical binding]; other site 693982008425 Q-loop/lid; other site 693982008426 ABC transporter signature motif; other site 693982008427 Walker B; other site 693982008428 D-loop; other site 693982008429 H-loop/switch region; other site 693982008430 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 693982008431 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982008432 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 693982008433 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 693982008434 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982008435 DNA binding residues [nucleotide binding] 693982008436 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 693982008437 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982008438 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982008439 LysR substrate binding domain; Region: LysR_substrate; pfam03466 693982008440 dimerization interface [polypeptide binding]; other site 693982008441 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 693982008442 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 693982008443 putative ligand binding site [chemical binding]; other site 693982008444 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 693982008445 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 693982008446 Walker A/P-loop; other site 693982008447 ATP binding site [chemical binding]; other site 693982008448 Q-loop/lid; other site 693982008449 ABC transporter signature motif; other site 693982008450 Walker B; other site 693982008451 D-loop; other site 693982008452 H-loop/switch region; other site 693982008453 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 693982008454 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 693982008455 Walker A/P-loop; other site 693982008456 ATP binding site [chemical binding]; other site 693982008457 Q-loop/lid; other site 693982008458 ABC transporter signature motif; other site 693982008459 Walker B; other site 693982008460 D-loop; other site 693982008461 H-loop/switch region; other site 693982008462 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982008463 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 693982008464 TM-ABC transporter signature motif; other site 693982008465 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 693982008466 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 693982008467 TM-ABC transporter signature motif; other site 693982008468 choline dehydrogenase; Validated; Region: PRK02106 693982008469 lycopene cyclase; Region: lycopene_cycl; TIGR01789 693982008470 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 693982008471 Transposase, Mutator family; Region: Transposase_mut; pfam00872 693982008472 MULE transposase domain; Region: MULE; pfam10551 693982008473 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 693982008474 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 693982008475 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 693982008476 substrate binding pocket [chemical binding]; other site 693982008477 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 693982008478 B12 binding site [chemical binding]; other site 693982008479 cobalt ligand [ion binding]; other site 693982008480 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 693982008481 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 693982008482 dimerization interface [polypeptide binding]; other site 693982008483 putative active cleft [active] 693982008484 hypothetical protein; Provisional; Region: PRK02487 693982008485 fructokinase; Reviewed; Region: PRK09557 693982008486 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693982008487 nucleotide binding site [chemical binding]; other site 693982008488 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 693982008489 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 693982008490 Predicted periplasmic protein [General function prediction only]; Region: COG3895 693982008491 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 693982008492 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 693982008493 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 693982008494 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 693982008495 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 693982008496 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 693982008497 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 693982008498 substrate-cofactor binding pocket; other site 693982008499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982008500 catalytic residue [active] 693982008501 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 693982008502 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 693982008503 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693982008504 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693982008505 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982008506 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693982008507 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693982008508 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982008509 cyclase homology domain; Region: CHD; cd07302 693982008510 nucleotidyl binding site; other site 693982008511 metal binding site [ion binding]; metal-binding site 693982008512 dimer interface [polypeptide binding]; other site 693982008513 Predicted integral membrane protein [Function unknown]; Region: COG5616 693982008514 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 693982008515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982008516 TPR motif; other site 693982008517 binding surface 693982008518 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693982008519 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 693982008520 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693982008521 Surface antigen; Region: Bac_surface_Ag; pfam01103 693982008522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 693982008523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 693982008524 Family of unknown function (DUF490); Region: DUF490; pfam04357 693982008525 Family of unknown function (DUF490); Region: DUF490; pfam04357 693982008526 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 693982008527 Phosphotransferase enzyme family; Region: APH; pfam01636 693982008528 active site 693982008529 ATP binding site [chemical binding]; other site 693982008530 antibiotic binding site [chemical binding]; other site 693982008531 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 693982008532 putative dimer interface [polypeptide binding]; other site 693982008533 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982008534 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982008535 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 693982008536 AsnC family; Region: AsnC_trans_reg; pfam01037 693982008537 Arginase family; Region: Arginase; cd09989 693982008538 active site 693982008539 Mn binding site [ion binding]; other site 693982008540 oligomer interface [polypeptide binding]; other site 693982008541 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 693982008542 putative CheA interaction surface; other site 693982008543 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982008544 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693982008545 putative active site [active] 693982008546 heme pocket [chemical binding]; other site 693982008547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982008548 putative active site [active] 693982008549 heme pocket [chemical binding]; other site 693982008550 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693982008551 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693982008552 dimer interface [polypeptide binding]; other site 693982008553 putative CheW interface [polypeptide binding]; other site 693982008554 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 693982008555 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 693982008556 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 693982008557 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982008558 catalytic loop [active] 693982008559 iron binding site [ion binding]; other site 693982008560 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 693982008561 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 693982008562 [4Fe-4S] binding site [ion binding]; other site 693982008563 molybdopterin cofactor binding site; other site 693982008564 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 693982008565 molybdopterin cofactor binding site; other site 693982008566 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 693982008567 putative dimer interface [polypeptide binding]; other site 693982008568 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 693982008569 SLBB domain; Region: SLBB; pfam10531 693982008570 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 693982008571 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 693982008572 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 693982008573 putative dimer interface [polypeptide binding]; other site 693982008574 [2Fe-2S] cluster binding site [ion binding]; other site 693982008575 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982008576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982008577 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693982008578 dimerization interface [polypeptide binding]; other site 693982008579 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 693982008580 classical (c) SDRs; Region: SDR_c; cd05233 693982008581 NAD(P) binding site [chemical binding]; other site 693982008582 active site 693982008583 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693982008584 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 693982008585 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693982008586 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 693982008587 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693982008588 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 693982008589 Walker A/P-loop; other site 693982008590 ATP binding site [chemical binding]; other site 693982008591 Q-loop/lid; other site 693982008592 ABC transporter signature motif; other site 693982008593 Walker B; other site 693982008594 D-loop; other site 693982008595 H-loop/switch region; other site 693982008596 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693982008597 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 693982008598 Walker A/P-loop; other site 693982008599 ATP binding site [chemical binding]; other site 693982008600 Q-loop/lid; other site 693982008601 ABC transporter signature motif; other site 693982008602 Walker B; other site 693982008603 D-loop; other site 693982008604 H-loop/switch region; other site 693982008605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982008606 dimer interface [polypeptide binding]; other site 693982008607 conserved gate region; other site 693982008608 putative PBP binding loops; other site 693982008609 ABC-ATPase subunit interface; other site 693982008610 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982008611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982008612 dimer interface [polypeptide binding]; other site 693982008613 conserved gate region; other site 693982008614 putative PBP binding loops; other site 693982008615 ABC-ATPase subunit interface; other site 693982008616 Predicted small integral membrane protein [Function unknown]; Region: COG5477 693982008617 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982008618 xanthine permease; Region: pbuX; TIGR03173 693982008619 xanthine permease; Region: pbuX; TIGR03173 693982008620 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 693982008621 EamA-like transporter family; Region: EamA; pfam00892 693982008622 EamA-like transporter family; Region: EamA; pfam00892 693982008623 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 693982008624 metal binding site 2 [ion binding]; metal-binding site 693982008625 putative DNA binding helix; other site 693982008626 metal binding site 1 [ion binding]; metal-binding site 693982008627 dimer interface [polypeptide binding]; other site 693982008628 structural Zn2+ binding site [ion binding]; other site 693982008629 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 693982008630 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 693982008631 metal binding site [ion binding]; metal-binding site 693982008632 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 693982008633 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 693982008634 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 693982008635 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693982008636 ABC-ATPase subunit interface; other site 693982008637 dimer interface [polypeptide binding]; other site 693982008638 putative PBP binding regions; other site 693982008639 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 693982008640 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693982008641 ABC-ATPase subunit interface; other site 693982008642 dimer interface [polypeptide binding]; other site 693982008643 putative PBP binding regions; other site 693982008644 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982008645 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 693982008646 AsnC family; Region: AsnC_trans_reg; pfam01037 693982008647 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 693982008648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982008649 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 693982008650 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 693982008651 gamma subunit interface [polypeptide binding]; other site 693982008652 epsilon subunit interface [polypeptide binding]; other site 693982008653 LBP interface [polypeptide binding]; other site 693982008654 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 693982008655 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693982008656 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 693982008657 alpha subunit interaction interface [polypeptide binding]; other site 693982008658 Walker A motif; other site 693982008659 ATP binding site [chemical binding]; other site 693982008660 Walker B motif; other site 693982008661 inhibitor binding site; inhibition site 693982008662 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 693982008663 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 693982008664 core domain interface [polypeptide binding]; other site 693982008665 delta subunit interface [polypeptide binding]; other site 693982008666 epsilon subunit interface [polypeptide binding]; other site 693982008667 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 693982008668 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693982008669 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 693982008670 beta subunit interaction interface [polypeptide binding]; other site 693982008671 Walker A motif; other site 693982008672 ATP binding site [chemical binding]; other site 693982008673 Walker B motif; other site 693982008674 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 693982008675 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 693982008676 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 693982008677 primosome assembly protein PriA; Validated; Region: PRK05580 693982008678 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693982008679 ATP binding site [chemical binding]; other site 693982008680 putative Mg++ binding site [ion binding]; other site 693982008681 helicase superfamily c-terminal domain; Region: HELICc; smart00490 693982008682 nucleotide binding region [chemical binding]; other site 693982008683 ATP-binding site [chemical binding]; other site 693982008684 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 693982008685 active site 693982008686 intersubunit interactions; other site 693982008687 catalytic residue [active] 693982008688 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693982008689 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 693982008690 Tetratricopeptide repeat; Region: TPR_16; pfam13432 693982008691 Protein of unknown function (DUF560); Region: DUF560; pfam04575 693982008692 Predicted ATPase [General function prediction only]; Region: COG4637 693982008693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982008694 Walker A/P-loop; other site 693982008695 ATP binding site [chemical binding]; other site 693982008696 Putative hemolysin [General function prediction only]; Region: COG3176 693982008697 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693982008698 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 693982008699 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693982008700 active site 693982008701 DNA binding site [nucleotide binding] 693982008702 Int/Topo IB signature motif; other site 693982008703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 693982008704 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 693982008705 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693982008706 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982008707 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693982008708 short chain dehydrogenase; Provisional; Region: PRK06123 693982008709 classical (c) SDRs; Region: SDR_c; cd05233 693982008710 NAD(P) binding site [chemical binding]; other site 693982008711 active site 693982008712 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693982008713 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 693982008714 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693982008715 E3 interaction surface; other site 693982008716 lipoyl attachment site [posttranslational modification]; other site 693982008717 e3 binding domain; Region: E3_binding; pfam02817 693982008718 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693982008719 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 693982008720 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 693982008721 TPP-binding site [chemical binding]; other site 693982008722 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 693982008723 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 693982008724 CoA binding domain; Region: CoA_binding; smart00881 693982008725 CoA-ligase; Region: Ligase_CoA; pfam00549 693982008726 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 693982008727 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 693982008728 CoA-ligase; Region: Ligase_CoA; pfam00549 693982008729 malate dehydrogenase; Reviewed; Region: PRK06223 693982008730 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 693982008731 NAD(P) binding site [chemical binding]; other site 693982008732 dimer interface [polypeptide binding]; other site 693982008733 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693982008734 substrate binding site [chemical binding]; other site 693982008735 Predicted ATPase [General function prediction only]; Region: COG1485 693982008736 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 693982008737 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982008738 non-specific DNA binding site [nucleotide binding]; other site 693982008739 salt bridge; other site 693982008740 sequence-specific DNA binding site [nucleotide binding]; other site 693982008741 Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549 693982008742 Protease inhibitor Inh; Region: Inh; pfam02974 693982008743 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982008744 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982008745 Walker A/P-loop; other site 693982008746 ATP binding site [chemical binding]; other site 693982008747 Q-loop/lid; other site 693982008748 ABC transporter signature motif; other site 693982008749 Walker B; other site 693982008750 D-loop; other site 693982008751 H-loop/switch region; other site 693982008752 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982008753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982008754 dimer interface [polypeptide binding]; other site 693982008755 conserved gate region; other site 693982008756 putative PBP binding loops; other site 693982008757 ABC-ATPase subunit interface; other site 693982008758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982008759 dimer interface [polypeptide binding]; other site 693982008760 conserved gate region; other site 693982008761 putative PBP binding loops; other site 693982008762 ABC-ATPase subunit interface; other site 693982008763 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982008764 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982008765 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 693982008766 putative Zn2+ binding site [ion binding]; other site 693982008767 putative DNA binding site [nucleotide binding]; other site 693982008768 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693982008769 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693982008770 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982008771 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982008772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828 693982008773 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 693982008774 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 693982008775 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 693982008776 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 693982008777 L-aspartate oxidase; Provisional; Region: PRK06175 693982008778 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693982008779 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 693982008780 putative SdhC subunit interface [polypeptide binding]; other site 693982008781 putative proximal heme binding site [chemical binding]; other site 693982008782 putative Iron-sulfur protein interface [polypeptide binding]; other site 693982008783 putative proximal quinone binding site; other site 693982008784 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 693982008785 Iron-sulfur protein interface; other site 693982008786 proximal quinone binding site [chemical binding]; other site 693982008787 SdhD (CybS) interface [polypeptide binding]; other site 693982008788 proximal heme binding site [chemical binding]; other site 693982008789 Predicted methyltransferase [General function prediction only]; Region: COG3897 693982008790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693982008791 Uncharacterized conserved protein [Function unknown]; Region: COG2947 693982008792 YciI-like protein; Reviewed; Region: PRK12865 693982008793 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 693982008794 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693982008795 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 693982008796 UGMP family protein; Validated; Region: PRK09604 693982008797 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 693982008798 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 693982008799 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 693982008800 domain interfaces; other site 693982008801 active site 693982008802 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 693982008803 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 693982008804 active site 693982008805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 693982008806 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 693982008807 HemY protein N-terminus; Region: HemY_N; pfam07219 693982008808 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 693982008809 putative metal binding site [ion binding]; other site 693982008810 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 693982008811 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 693982008812 catalytic triad [active] 693982008813 enterobactin exporter EntS; Provisional; Region: PRK10489 693982008814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982008815 putative substrate translocation pore; other site 693982008816 YGGT family; Region: YGGT; pfam02325 693982008817 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 693982008818 dimer interface [polypeptide binding]; other site 693982008819 substrate binding site [chemical binding]; other site 693982008820 metal binding sites [ion binding]; metal-binding site 693982008821 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693982008822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982008823 Coenzyme A binding pocket [chemical binding]; other site 693982008824 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 693982008825 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 693982008826 G1 box; other site 693982008827 putative GEF interaction site [polypeptide binding]; other site 693982008828 GTP/Mg2+ binding site [chemical binding]; other site 693982008829 Switch I region; other site 693982008830 G2 box; other site 693982008831 G3 box; other site 693982008832 Switch II region; other site 693982008833 G4 box; other site 693982008834 G5 box; other site 693982008835 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 693982008836 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 693982008837 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 693982008838 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 693982008839 putative active site [active] 693982008840 putative metal binding site [ion binding]; other site 693982008841 KTSC domain; Region: KTSC; pfam13619 693982008842 amidase; Provisional; Region: PRK07056 693982008843 amidase; Validated; Region: PRK05962 693982008844 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 693982008845 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 693982008846 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 693982008847 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 693982008848 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693982008849 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693982008850 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693982008851 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693982008852 GTPase CgtA; Reviewed; Region: obgE; PRK12299 693982008853 GTP1/OBG; Region: GTP1_OBG; pfam01018 693982008854 Obg GTPase; Region: Obg; cd01898 693982008855 G1 box; other site 693982008856 GTP/Mg2+ binding site [chemical binding]; other site 693982008857 Switch I region; other site 693982008858 G2 box; other site 693982008859 G3 box; other site 693982008860 Switch II region; other site 693982008861 G4 box; other site 693982008862 G5 box; other site 693982008863 gamma-glutamyl kinase; Provisional; Region: PRK05429 693982008864 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 693982008865 nucleotide binding site [chemical binding]; other site 693982008866 homotetrameric interface [polypeptide binding]; other site 693982008867 putative phosphate binding site [ion binding]; other site 693982008868 putative allosteric binding site; other site 693982008869 PUA domain; Region: PUA; pfam01472 693982008870 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 693982008871 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 693982008872 putative catalytic cysteine [active] 693982008873 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 693982008874 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 693982008875 active site 693982008876 (T/H)XGH motif; other site 693982008877 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 693982008878 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 693982008879 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 693982008880 Peptidase family M23; Region: Peptidase_M23; pfam01551 693982008881 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 693982008882 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 693982008883 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 693982008884 protein binding site [polypeptide binding]; other site 693982008885 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 693982008886 Catalytic dyad [active] 693982008887 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 693982008888 NodB motif; other site 693982008889 putative active site [active] 693982008890 putative catalytic site [active] 693982008891 Zn binding site [ion binding]; other site 693982008892 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 693982008893 putative active site [active] 693982008894 Ap4A binding site [chemical binding]; other site 693982008895 nudix motif; other site 693982008896 putative metal binding site [ion binding]; other site 693982008897 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 693982008898 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 693982008899 heme binding site [chemical binding]; other site 693982008900 ferroxidase pore; other site 693982008901 ferroxidase diiron center [ion binding]; other site 693982008902 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 693982008903 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 693982008904 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 693982008905 putative active site [active] 693982008906 putative PHP Thumb interface [polypeptide binding]; other site 693982008907 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 693982008908 generic binding surface II; other site 693982008909 generic binding surface I; other site 693982008910 DNA Polymerase Y-family; Region: PolY_like; cd03468 693982008911 active site 693982008912 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 693982008913 DNA binding site [nucleotide binding] 693982008914 Uncharacterized conserved protein [Function unknown]; Region: COG4544 693982008915 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 693982008916 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 693982008917 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 693982008918 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 693982008919 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 693982008920 substrate binding site [chemical binding]; other site 693982008921 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 693982008922 homotrimer interaction site [polypeptide binding]; other site 693982008923 putative active site [active] 693982008924 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 693982008925 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 693982008926 proposed active site lysine [active] 693982008927 conserved cys residue [active] 693982008928 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 693982008929 active site 693982008930 catalytic residues [active] 693982008931 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 693982008932 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 693982008933 P-loop, Walker A motif; other site 693982008934 Base recognition motif; other site 693982008935 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 693982008936 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 693982008937 putative deacylase active site [active] 693982008938 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 693982008939 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693982008940 catalytic residues [active] 693982008941 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 693982008942 Uncharacterized conserved protein [Function unknown]; Region: COG2835 693982008943 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 693982008944 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693982008945 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 693982008946 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 693982008947 active site 693982008948 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 693982008949 catalytic triad [active] 693982008950 dimer interface [polypeptide binding]; other site 693982008951 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 693982008952 Nitrogen regulatory protein P-II; Region: P-II; smart00938 693982008953 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 693982008954 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 693982008955 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 693982008956 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 693982008957 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 693982008958 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 693982008959 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 693982008960 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693982008961 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693982008962 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982008963 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982008964 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 693982008965 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693982008966 ligand binding site [chemical binding]; other site 693982008967 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982008968 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982008969 TM-ABC transporter signature motif; other site 693982008970 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 693982008971 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982008972 Walker A/P-loop; other site 693982008973 ATP binding site [chemical binding]; other site 693982008974 Q-loop/lid; other site 693982008975 ABC transporter signature motif; other site 693982008976 Walker B; other site 693982008977 D-loop; other site 693982008978 H-loop/switch region; other site 693982008979 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693982008980 MarR family; Region: MarR_2; pfam12802 693982008981 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693982008982 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693982008983 nucleotide binding site [chemical binding]; other site 693982008984 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693982008985 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693982008986 nucleotide binding site [chemical binding]; other site 693982008987 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 693982008988 putative catalytic site [active] 693982008989 putative phosphate binding site [ion binding]; other site 693982008990 active site 693982008991 metal binding site A [ion binding]; metal-binding site 693982008992 DNA binding site [nucleotide binding] 693982008993 putative AP binding site [nucleotide binding]; other site 693982008994 putative metal binding site B [ion binding]; other site 693982008995 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693982008996 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693982008997 ligand binding site [chemical binding]; other site 693982008998 flexible hinge region; other site 693982008999 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982009000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982009001 active site 693982009002 phosphorylation site [posttranslational modification] 693982009003 intermolecular recognition site; other site 693982009004 dimerization interface [polypeptide binding]; other site 693982009005 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982009006 DNA binding site [nucleotide binding] 693982009007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 693982009008 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693982009009 catalytic core [active] 693982009010 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 693982009011 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 693982009012 substrate binding site [chemical binding]; other site 693982009013 ligand binding site [chemical binding]; other site 693982009014 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693982009015 MarR family; Region: MarR_2; pfam12802 693982009016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982009017 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693982009018 putative substrate translocation pore; other site 693982009019 argininosuccinate synthase; Provisional; Region: PRK13820 693982009020 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 693982009021 ANP binding site [chemical binding]; other site 693982009022 Substrate Binding Site II [chemical binding]; other site 693982009023 Substrate Binding Site I [chemical binding]; other site 693982009024 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693982009025 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 693982009026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982009027 Walker A/P-loop; other site 693982009028 ATP binding site [chemical binding]; other site 693982009029 Q-loop/lid; other site 693982009030 ABC transporter signature motif; other site 693982009031 Walker B; other site 693982009032 D-loop; other site 693982009033 H-loop/switch region; other site 693982009034 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982009035 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 693982009036 TM-ABC transporter signature motif; other site 693982009037 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 693982009038 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693982009039 zinc binding site [ion binding]; other site 693982009040 putative ligand binding site [chemical binding]; other site 693982009041 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 693982009042 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693982009043 FeS/SAM binding site; other site 693982009044 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 693982009045 Uncharacterized conserved protein [Function unknown]; Region: COG3339 693982009046 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 693982009047 aromatic arch; other site 693982009048 DCoH dimer interaction site [polypeptide binding]; other site 693982009049 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 693982009050 DCoH tetramer interaction site [polypeptide binding]; other site 693982009051 substrate binding site [chemical binding]; other site 693982009052 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 693982009053 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 693982009054 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 693982009055 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 693982009056 active site 693982009057 catalytic triad [active] 693982009058 oxyanion hole [active] 693982009059 switch loop; other site 693982009060 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 693982009061 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693982009062 Walker A/P-loop; other site 693982009063 ATP binding site [chemical binding]; other site 693982009064 Q-loop/lid; other site 693982009065 ABC transporter signature motif; other site 693982009066 Walker B; other site 693982009067 D-loop; other site 693982009068 H-loop/switch region; other site 693982009069 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 693982009070 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 693982009071 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 693982009072 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 693982009073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982009074 Coenzyme A binding pocket [chemical binding]; other site 693982009075 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 693982009076 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 693982009077 oligomer interface [polypeptide binding]; other site 693982009078 active site residues [active] 693982009079 Uncharacterized conserved protein [Function unknown]; Region: COG3832 693982009080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982009081 dimerization interface [polypeptide binding]; other site 693982009082 putative DNA binding site [nucleotide binding]; other site 693982009083 putative Zn2+ binding site [ion binding]; other site 693982009084 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 693982009085 Uncharacterized secreted protein [Function unknown]; Region: COG5429 693982009086 aconitate hydratase; Validated; Region: PRK09277 693982009087 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 693982009088 substrate binding site [chemical binding]; other site 693982009089 ligand binding site [chemical binding]; other site 693982009090 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 693982009091 substrate binding site [chemical binding]; other site 693982009092 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 693982009093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982009094 Walker A/P-loop; other site 693982009095 ATP binding site [chemical binding]; other site 693982009096 Q-loop/lid; other site 693982009097 ABC transporter signature motif; other site 693982009098 Walker B; other site 693982009099 D-loop; other site 693982009100 H-loop/switch region; other site 693982009101 heme exporter protein CcmB; Region: ccmB; TIGR01190 693982009102 heme exporter protein CcmC; Region: ccmC; TIGR01191 693982009103 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 693982009104 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 693982009105 catalytic residues [active] 693982009106 central insert; other site 693982009107 hypothetical protein; Provisional; Region: PRK00944 693982009108 intracellular septation protein A; Reviewed; Region: PRK00259 693982009109 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 693982009110 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 693982009111 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693982009112 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 693982009113 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693982009114 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693982009115 FeS/SAM binding site; other site 693982009116 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 693982009117 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 693982009118 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 693982009119 signal recognition particle protein; Provisional; Region: PRK10867 693982009120 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 693982009121 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 693982009122 P loop; other site 693982009123 GTP binding site [chemical binding]; other site 693982009124 Signal peptide binding domain; Region: SRP_SPB; pfam02978 693982009125 chorismate mutase; Provisional; Region: PRK09239 693982009126 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 693982009127 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 693982009128 RimM N-terminal domain; Region: RimM; pfam01782 693982009129 PRC-barrel domain; Region: PRC; pfam05239 693982009130 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 693982009131 hypothetical protein; Provisional; Region: PRK10621 693982009132 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693982009133 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 693982009134 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693982009135 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982009136 substrate binding pocket [chemical binding]; other site 693982009137 membrane-bound complex binding site; other site 693982009138 hinge residues; other site 693982009139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982009140 dimer interface [polypeptide binding]; other site 693982009141 conserved gate region; other site 693982009142 putative PBP binding loops; other site 693982009143 ABC-ATPase subunit interface; other site 693982009144 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 693982009145 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693982009146 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693982009147 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 693982009148 Thiamine pyrophosphokinase; Region: TPK; cd07995 693982009149 active site 693982009150 dimerization interface [polypeptide binding]; other site 693982009151 thiamine binding site [chemical binding]; other site 693982009152 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 693982009153 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 693982009154 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 693982009155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982009156 ABC-ATPase subunit interface; other site 693982009157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693982009158 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 693982009159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982009160 Walker A/P-loop; other site 693982009161 ATP binding site [chemical binding]; other site 693982009162 Q-loop/lid; other site 693982009163 ABC transporter signature motif; other site 693982009164 Walker B; other site 693982009165 D-loop; other site 693982009166 H-loop/switch region; other site 693982009167 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 693982009168 Peptidase family M48; Region: Peptidase_M48; pfam01435 693982009169 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 693982009170 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 693982009171 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982009172 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982009173 DNA binding residues [nucleotide binding] 693982009174 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 693982009175 Ferredoxin [Energy production and conversion]; Region: COG1146 693982009176 4Fe-4S binding domain; Region: Fer4; pfam00037 693982009177 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 693982009178 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693982009179 RNA binding surface [nucleotide binding]; other site 693982009180 DEAD/DEAH box helicase; Region: DEAD; pfam00270 693982009181 ATP binding site [chemical binding]; other site 693982009182 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 693982009183 putative Mg++ binding site [ion binding]; other site 693982009184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693982009185 nucleotide binding region [chemical binding]; other site 693982009186 ATP-binding site [chemical binding]; other site 693982009187 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 693982009188 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 693982009189 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 693982009190 NAD(P) binding site [chemical binding]; other site 693982009191 homotetramer interface [polypeptide binding]; other site 693982009192 homodimer interface [polypeptide binding]; other site 693982009193 active site 693982009194 putative acyltransferase; Provisional; Region: PRK05790 693982009195 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693982009196 dimer interface [polypeptide binding]; other site 693982009197 active site 693982009198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 693982009199 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 693982009200 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 693982009201 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 693982009202 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 693982009203 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982009204 putative C-terminal domain interface [polypeptide binding]; other site 693982009205 putative GSH binding site (G-site) [chemical binding]; other site 693982009206 putative dimer interface [polypeptide binding]; other site 693982009207 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 693982009208 putative dimer interface [polypeptide binding]; other site 693982009209 putative N-terminal domain interface [polypeptide binding]; other site 693982009210 putative substrate binding pocket (H-site) [chemical binding]; other site 693982009211 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 693982009212 Transglycosylase; Region: Transgly; cl17702 693982009213 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 693982009214 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 693982009215 substrate binding pocket [chemical binding]; other site 693982009216 chain length determination region; other site 693982009217 substrate-Mg2+ binding site; other site 693982009218 catalytic residues [active] 693982009219 aspartate-rich region 1; other site 693982009220 active site lid residues [active] 693982009221 aspartate-rich region 2; other site 693982009222 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 693982009223 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982009224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982009225 homodimer interface [polypeptide binding]; other site 693982009226 catalytic residue [active] 693982009227 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693982009228 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 693982009229 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 693982009230 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 693982009231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982009232 putative substrate translocation pore; other site 693982009233 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693982009234 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 693982009235 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693982009236 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693982009237 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982009238 substrate binding pocket [chemical binding]; other site 693982009239 membrane-bound complex binding site; other site 693982009240 hinge residues; other site 693982009241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982009242 dimer interface [polypeptide binding]; other site 693982009243 conserved gate region; other site 693982009244 putative PBP binding loops; other site 693982009245 ABC-ATPase subunit interface; other site 693982009246 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693982009247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982009248 Walker A/P-loop; other site 693982009249 ATP binding site [chemical binding]; other site 693982009250 Q-loop/lid; other site 693982009251 ABC transporter signature motif; other site 693982009252 Walker B; other site 693982009253 D-loop; other site 693982009254 H-loop/switch region; other site 693982009255 pyruvate carboxylase; Reviewed; Region: PRK12999 693982009256 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693982009257 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 693982009258 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693982009259 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 693982009260 active site 693982009261 catalytic residues [active] 693982009262 metal binding site [ion binding]; metal-binding site 693982009263 homodimer binding site [polypeptide binding]; other site 693982009264 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693982009265 carboxyltransferase (CT) interaction site; other site 693982009266 biotinylation site [posttranslational modification]; other site 693982009267 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 693982009268 Autoinducer binding domain; Region: Autoind_bind; pfam03472 693982009269 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982009270 DNA binding residues [nucleotide binding] 693982009271 dimerization interface [polypeptide binding]; other site 693982009272 glucan exporter ATP-binding protein; Region: chvA; TIGR01192 693982009273 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693982009274 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 693982009275 Walker A/P-loop; other site 693982009276 ATP binding site [chemical binding]; other site 693982009277 Q-loop/lid; other site 693982009278 ABC transporter signature motif; other site 693982009279 Walker B; other site 693982009280 D-loop; other site 693982009281 H-loop/switch region; other site 693982009282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645 693982009283 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 693982009284 Putative glucoamylase; Region: Glycoamylase; pfam10091 693982009285 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 693982009286 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 693982009287 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 693982009288 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693982009289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982009290 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 693982009291 dimerization interface [polypeptide binding]; other site 693982009292 substrate binding pocket [chemical binding]; other site 693982009293 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 693982009294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 693982009295 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693982009296 FAD binding domain; Region: FAD_binding_4; pfam01565 693982009297 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 693982009298 aldehyde dehydrogenase family 7 member; Region: PLN02315 693982009299 tetrameric interface [polypeptide binding]; other site 693982009300 NAD binding site [chemical binding]; other site 693982009301 catalytic residues [active] 693982009302 aspartate aminotransferase; Provisional; Region: PRK05764 693982009303 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982009304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982009305 homodimer interface [polypeptide binding]; other site 693982009306 catalytic residue [active] 693982009307 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 693982009308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982009309 non-specific DNA binding site [nucleotide binding]; other site 693982009310 salt bridge; other site 693982009311 sequence-specific DNA binding site [nucleotide binding]; other site 693982009312 Cupin domain; Region: Cupin_2; pfam07883 693982009313 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 693982009314 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693982009315 inhibitor-cofactor binding pocket; inhibition site 693982009316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982009317 catalytic residue [active] 693982009318 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 693982009319 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 693982009320 MOFRL family; Region: MOFRL; pfam05161 693982009321 choline dehydrogenase; Validated; Region: PRK02106 693982009322 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 693982009323 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 693982009324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982009325 NAD(P) binding site [chemical binding]; other site 693982009326 active site 693982009327 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982009328 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982009329 Walker A/P-loop; other site 693982009330 ATP binding site [chemical binding]; other site 693982009331 Q-loop/lid; other site 693982009332 ABC transporter signature motif; other site 693982009333 Walker B; other site 693982009334 D-loop; other site 693982009335 H-loop/switch region; other site 693982009336 TOBE domain; Region: TOBE; cl01440 693982009337 TOBE domain; Region: TOBE_2; pfam08402 693982009338 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982009339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982009340 dimer interface [polypeptide binding]; other site 693982009341 conserved gate region; other site 693982009342 putative PBP binding loops; other site 693982009343 ABC-ATPase subunit interface; other site 693982009344 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982009345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982009346 dimer interface [polypeptide binding]; other site 693982009347 conserved gate region; other site 693982009348 putative PBP binding loops; other site 693982009349 ABC-ATPase subunit interface; other site 693982009350 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982009351 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 693982009352 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693982009353 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 693982009354 NAD(P) binding site [chemical binding]; other site 693982009355 catalytic residues [active] 693982009356 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 693982009357 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693982009358 substrate binding site [chemical binding]; other site 693982009359 oxyanion hole (OAH) forming residues; other site 693982009360 trimer interface [polypeptide binding]; other site 693982009361 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 693982009362 Coenzyme A transferase; Region: CoA_trans; smart00882 693982009363 Coenzyme A transferase; Region: CoA_trans; cl17247 693982009364 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982009365 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982009366 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982009367 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982009368 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982009369 DNA binding site [nucleotide binding] 693982009370 domain linker motif; other site 693982009371 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 693982009372 putative dimerization interface [polypeptide binding]; other site 693982009373 putative ligand binding site [chemical binding]; other site 693982009374 Protein of unknown function (DUF993); Region: DUF993; pfam06187 693982009375 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 693982009376 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 693982009377 active site 693982009378 Zn binding site [ion binding]; other site 693982009379 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693982009380 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 693982009381 tartrate dehydrogenase; Region: TTC; TIGR02089 693982009382 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 693982009383 active site 693982009384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982009385 putative substrate translocation pore; other site 693982009386 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 693982009387 oligomeric interface; other site 693982009388 putative active site [active] 693982009389 homodimer interface [polypeptide binding]; other site 693982009390 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 693982009391 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 693982009392 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693982009393 Transglycosylase SLT domain; Region: SLT_2; pfam13406 693982009394 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693982009395 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693982009396 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 693982009397 active site clefts [active] 693982009398 zinc binding site [ion binding]; other site 693982009399 dimer interface [polypeptide binding]; other site 693982009400 pyridoxamine kinase; Validated; Region: PRK05756 693982009401 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 693982009402 pyridoxal binding site [chemical binding]; other site 693982009403 dimer interface [polypeptide binding]; other site 693982009404 ATP binding site [chemical binding]; other site 693982009405 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 693982009406 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 693982009407 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 693982009408 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 693982009409 purine monophosphate binding site [chemical binding]; other site 693982009410 dimer interface [polypeptide binding]; other site 693982009411 putative catalytic residues [active] 693982009412 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 693982009413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 693982009414 NusB family; Region: NusB; pfam01029 693982009415 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 693982009416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982009417 S-adenosylmethionine binding site [chemical binding]; other site 693982009418 heat shock protein HtpX; Provisional; Region: PRK01345 693982009419 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 693982009420 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 693982009421 acetyl-CoA synthetase; Provisional; Region: PRK00174 693982009422 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 693982009423 active site 693982009424 CoA binding site [chemical binding]; other site 693982009425 acyl-activating enzyme (AAE) consensus motif; other site 693982009426 AMP binding site [chemical binding]; other site 693982009427 acetate binding site [chemical binding]; other site 693982009428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 693982009429 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 693982009430 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693982009431 acyl-activating enzyme (AAE) consensus motif; other site 693982009432 AMP binding site [chemical binding]; other site 693982009433 active site 693982009434 CoA binding site [chemical binding]; other site 693982009435 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 693982009436 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693982009437 catalytic residue [active] 693982009438 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 693982009439 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 693982009440 HIGH motif; other site 693982009441 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 693982009442 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693982009443 active site 693982009444 KMSKS motif; other site 693982009445 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 693982009446 tRNA binding surface [nucleotide binding]; other site 693982009447 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 693982009448 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 693982009449 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 693982009450 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 693982009451 ParB-like nuclease domain; Region: ParBc; pfam02195 693982009452 KorB domain; Region: KorB; pfam08535 693982009453 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693982009454 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693982009455 P-loop; other site 693982009456 Magnesium ion binding site [ion binding]; other site 693982009457 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693982009458 Magnesium ion binding site [ion binding]; other site 693982009459 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 693982009460 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 693982009461 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 693982009462 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 693982009463 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 693982009464 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 693982009465 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 693982009466 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 693982009467 trmE is a tRNA modification GTPase; Region: trmE; cd04164 693982009468 G1 box; other site 693982009469 GTP/Mg2+ binding site [chemical binding]; other site 693982009470 Switch I region; other site 693982009471 G2 box; other site 693982009472 Switch II region; other site 693982009473 G3 box; other site 693982009474 G4 box; other site 693982009475 G5 box; other site 693982009476 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 693982009477 transcription termination factor Rho; Provisional; Region: rho; PRK09376 693982009478 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 693982009479 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 693982009480 RNA binding site [nucleotide binding]; other site 693982009481 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 693982009482 multimer interface [polypeptide binding]; other site 693982009483 Walker A motif; other site 693982009484 ATP binding site [chemical binding]; other site 693982009485 Walker B motif; other site 693982009486 Predicted membrane protein [Function unknown]; Region: COG1981 693982009487 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 693982009488 substrate binding site [chemical binding]; other site 693982009489 active site 693982009490 PEP synthetase regulatory protein; Provisional; Region: PRK05339 693982009491 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 693982009492 active site 693982009493 dimer interface [polypeptide binding]; other site 693982009494 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 693982009495 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 693982009496 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 693982009497 shikimate binding site; other site 693982009498 NAD(P) binding site [chemical binding]; other site 693982009499 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 693982009500 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 693982009501 CoA-binding site [chemical binding]; other site 693982009502 ATP-binding [chemical binding]; other site 693982009503 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 693982009504 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 693982009505 active site 693982009506 catalytic site [active] 693982009507 substrate binding site [chemical binding]; other site 693982009508 Preprotein translocase subunit SecB [Intracellular trafficking and secretion]; Region: SecB; COG1952 693982009509 SecA binding site; other site 693982009510 Preprotein binding site; other site 693982009511 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 693982009512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 693982009513 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 693982009514 MltA specific insert domain; Region: MltA; pfam03562 693982009515 3D domain; Region: 3D; pfam06725 693982009516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 693982009517 Smr domain; Region: Smr; pfam01713 693982009518 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982009519 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982009520 non-specific DNA binding site [nucleotide binding]; other site 693982009521 salt bridge; other site 693982009522 sequence-specific DNA binding site [nucleotide binding]; other site 693982009523 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 693982009524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982009525 Mg2+ binding site [ion binding]; other site 693982009526 G-X-G motif; other site 693982009527 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 693982009528 anchoring element; other site 693982009529 dimer interface [polypeptide binding]; other site 693982009530 ATP binding site [chemical binding]; other site 693982009531 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 693982009532 active site 693982009533 putative metal-binding site [ion binding]; other site 693982009534 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 693982009535 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 693982009536 putative FMN binding site [chemical binding]; other site 693982009537 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 693982009538 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 693982009539 tetramerization interface [polypeptide binding]; other site 693982009540 NAD(P) binding site [chemical binding]; other site 693982009541 catalytic residues [active] 693982009542 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 693982009543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 693982009544 DNA-binding site [nucleotide binding]; DNA binding site 693982009545 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982009546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 693982009547 DNA-binding site [nucleotide binding]; DNA binding site 693982009548 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693982009549 galactarate dehydratase; Region: galactar-dH20; TIGR03248 693982009550 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 693982009551 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 693982009552 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982009553 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982009554 active site 693982009555 catalytic tetrad [active] 693982009556 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 693982009557 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693982009558 putative ligand binding site [chemical binding]; other site 693982009559 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982009560 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982009561 Walker A/P-loop; other site 693982009562 ATP binding site [chemical binding]; other site 693982009563 Q-loop/lid; other site 693982009564 ABC transporter signature motif; other site 693982009565 Walker B; other site 693982009566 D-loop; other site 693982009567 H-loop/switch region; other site 693982009568 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982009569 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982009570 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982009571 TM-ABC transporter signature motif; other site 693982009572 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693982009573 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 693982009574 putative NAD(P) binding site [chemical binding]; other site 693982009575 catalytic Zn binding site [ion binding]; other site 693982009576 structural Zn binding site [ion binding]; other site 693982009577 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 693982009578 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 693982009579 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 693982009580 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 693982009581 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 693982009582 active site 693982009583 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 693982009584 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 693982009585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982009586 catalytic residue [active] 693982009587 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 693982009588 substrate binding site [chemical binding]; other site 693982009589 active site 693982009590 catalytic residues [active] 693982009591 heterodimer interface [polypeptide binding]; other site 693982009592 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 693982009593 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 693982009594 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 693982009595 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693982009596 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 693982009597 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 693982009598 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982009599 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693982009600 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693982009601 catalytic residues [active] 693982009602 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 693982009603 Family description; Region: UvrD_C_2; pfam13538 693982009604 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 693982009605 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 693982009606 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 693982009607 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 693982009608 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 693982009609 Substrate binding site; other site 693982009610 metal-binding site 693982009611 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 693982009612 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 693982009613 Phosphotransferase enzyme family; Region: APH; pfam01636 693982009614 PAS fold; Region: PAS_7; pfam12860 693982009615 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 693982009616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982009617 dimer interface [polypeptide binding]; other site 693982009618 phosphorylation site [posttranslational modification] 693982009619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982009620 ATP binding site [chemical binding]; other site 693982009621 Mg2+ binding site [ion binding]; other site 693982009622 G-X-G motif; other site 693982009623 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 693982009624 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 693982009625 homotetramer interface [polypeptide binding]; other site 693982009626 ligand binding site [chemical binding]; other site 693982009627 catalytic site [active] 693982009628 NAD binding site [chemical binding]; other site 693982009629 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693982009630 dimerization domain swap beta strand [polypeptide binding]; other site 693982009631 regulatory protein interface [polypeptide binding]; other site 693982009632 active site 693982009633 regulatory phosphorylation site [posttranslational modification]; other site 693982009634 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 693982009635 active pocket/dimerization site; other site 693982009636 active site 693982009637 phosphorylation site [posttranslational modification] 693982009638 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 693982009639 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 693982009640 Hpr binding site; other site 693982009641 active site 693982009642 homohexamer subunit interaction site [polypeptide binding]; other site 693982009643 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 693982009644 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 693982009645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982009646 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693982009647 dimerization interface [polypeptide binding]; other site 693982009648 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982009649 dimer interface [polypeptide binding]; other site 693982009650 phosphorylation site [posttranslational modification] 693982009651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982009652 ATP binding site [chemical binding]; other site 693982009653 Mg2+ binding site [ion binding]; other site 693982009654 G-X-G motif; other site 693982009655 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982009656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982009657 active site 693982009658 phosphorylation site [posttranslational modification] 693982009659 intermolecular recognition site; other site 693982009660 dimerization interface [polypeptide binding]; other site 693982009661 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982009662 DNA binding site [nucleotide binding] 693982009663 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 693982009664 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 693982009665 active site 693982009666 substrate-binding site [chemical binding]; other site 693982009667 metal-binding site [ion binding] 693982009668 ATP binding site [chemical binding]; other site 693982009669 hypothetical protein; Provisional; Region: PRK09256 693982009670 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 693982009671 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 693982009672 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693982009673 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 693982009674 pantothenate kinase; Provisional; Region: PRK05439 693982009675 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 693982009676 ATP-binding site [chemical binding]; other site 693982009677 CoA-binding site [chemical binding]; other site 693982009678 Mg2+-binding site [ion binding]; other site 693982009679 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 693982009680 metal binding site [ion binding]; metal-binding site 693982009681 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 693982009682 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 693982009683 substrate binding site [chemical binding]; other site 693982009684 glutamase interaction surface [polypeptide binding]; other site 693982009685 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 693982009686 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 693982009687 catalytic residues [active] 693982009688 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 693982009689 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 693982009690 putative active site [active] 693982009691 oxyanion strand; other site 693982009692 catalytic triad [active] 693982009693 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 693982009694 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 693982009695 putative active site pocket [active] 693982009696 4-fold oligomerization interface [polypeptide binding]; other site 693982009697 metal binding residues [ion binding]; metal-binding site 693982009698 3-fold/trimer interface [polypeptide binding]; other site 693982009699 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 693982009700 active site 693982009701 HslU subunit interaction site [polypeptide binding]; other site 693982009702 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693982009703 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 693982009704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693982009705 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 693982009706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982009707 Walker A motif; other site 693982009708 ATP binding site [chemical binding]; other site 693982009709 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 693982009710 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693982009711 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 693982009712 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 693982009713 Cytochrome P450; Region: p450; cl12078 693982009714 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 693982009715 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 693982009716 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 693982009717 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 693982009718 active site 693982009719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 693982009720 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693982009721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5321 693982009722 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 693982009723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982009724 active site 693982009725 phosphorylation site [posttranslational modification] 693982009726 intermolecular recognition site; other site 693982009727 dimerization interface [polypeptide binding]; other site 693982009728 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 693982009729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982009730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982009731 dimer interface [polypeptide binding]; other site 693982009732 phosphorylation site [posttranslational modification] 693982009733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982009734 ATP binding site [chemical binding]; other site 693982009735 Mg2+ binding site [ion binding]; other site 693982009736 G-X-G motif; other site 693982009737 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 693982009738 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693982009739 ATP binding site [chemical binding]; other site 693982009740 putative Mg++ binding site [ion binding]; other site 693982009741 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693982009742 nucleotide binding region [chemical binding]; other site 693982009743 ATP-binding site [chemical binding]; other site 693982009744 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 693982009745 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 693982009746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982009747 Walker A/P-loop; other site 693982009748 ATP binding site [chemical binding]; other site 693982009749 Q-loop/lid; other site 693982009750 ABC transporter signature motif; other site 693982009751 Walker B; other site 693982009752 D-loop; other site 693982009753 H-loop/switch region; other site 693982009754 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 693982009755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982009756 dimer interface [polypeptide binding]; other site 693982009757 conserved gate region; other site 693982009758 putative PBP binding loops; other site 693982009759 ABC-ATPase subunit interface; other site 693982009760 hypothetical protein; Provisional; Region: PRK11622 693982009761 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 693982009762 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 693982009763 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 693982009764 O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080 693982009765 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693982009766 homodimer interface [polypeptide binding]; other site 693982009767 substrate-cofactor binding pocket; other site 693982009768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982009769 catalytic residue [active] 693982009770 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982009771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982009772 LysR substrate binding domain; Region: LysR_substrate; pfam03466 693982009773 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 693982009774 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 693982009775 HPP family; Region: HPP; pfam04982 693982009776 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 693982009777 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 693982009778 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 693982009779 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 693982009780 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 693982009781 homodimer interface [polypeptide binding]; other site 693982009782 NADP binding site [chemical binding]; other site 693982009783 substrate binding site [chemical binding]; other site 693982009784 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 693982009785 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 693982009786 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 693982009787 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693982009788 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 693982009789 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 693982009790 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693982009791 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 693982009792 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 693982009793 conserved cys residue [active] 693982009794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982009795 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 693982009796 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 693982009797 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 693982009798 putative active site [active] 693982009799 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 693982009800 domain_subunit interface; other site 693982009801 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 693982009802 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 693982009803 active site 693982009804 FMN binding site [chemical binding]; other site 693982009805 substrate binding site [chemical binding]; other site 693982009806 3Fe-4S cluster binding site [ion binding]; other site 693982009807 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 693982009808 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693982009809 ethanolamine permease; Region: 2A0305; TIGR00908 693982009810 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 693982009811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982009812 non-specific DNA binding site [nucleotide binding]; other site 693982009813 salt bridge; other site 693982009814 sequence-specific DNA binding site [nucleotide binding]; other site 693982009815 Cupin domain; Region: Cupin_2; pfam07883 693982009816 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 693982009817 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 693982009818 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 693982009819 putative active site [active] 693982009820 putative substrate binding site [chemical binding]; other site 693982009821 putative cosubstrate binding site; other site 693982009822 catalytic site [active] 693982009823 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 693982009824 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693982009825 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 693982009826 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 693982009827 FMN-binding pocket [chemical binding]; other site 693982009828 flavin binding motif; other site 693982009829 phosphate binding motif [ion binding]; other site 693982009830 beta-alpha-beta structure motif; other site 693982009831 NAD binding pocket [chemical binding]; other site 693982009832 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982009833 catalytic loop [active] 693982009834 iron binding site [ion binding]; other site 693982009835 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 693982009836 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 693982009837 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693982009838 Uncharacterized conserved protein [Function unknown]; Region: COG3665 693982009839 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 693982009840 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693982009841 Amino acid permease; Region: AA_permease_2; pfam13520 693982009842 putative phosphoketolase; Provisional; Region: PRK05261 693982009843 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 693982009844 TPP-binding site; other site 693982009845 XFP C-terminal domain; Region: XFP_C; pfam09363 693982009846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982009847 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 693982009848 NAD(P) binding site [chemical binding]; other site 693982009849 active site 693982009850 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 693982009851 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982009852 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982009853 DNA-binding site [nucleotide binding]; DNA binding site 693982009854 FCD domain; Region: FCD; pfam07729 693982009855 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 693982009856 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982009857 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693982009858 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 693982009859 N-terminal domain interface [polypeptide binding]; other site 693982009860 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982009861 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982009862 Walker A/P-loop; other site 693982009863 ATP binding site [chemical binding]; other site 693982009864 Q-loop/lid; other site 693982009865 ABC transporter signature motif; other site 693982009866 Walker B; other site 693982009867 D-loop; other site 693982009868 H-loop/switch region; other site 693982009869 TOBE domain; Region: TOBE_2; pfam08402 693982009870 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982009871 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982009872 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982009873 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982009874 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982009875 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982009876 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982009877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982009878 dimer interface [polypeptide binding]; other site 693982009879 conserved gate region; other site 693982009880 putative PBP binding loops; other site 693982009881 ABC-ATPase subunit interface; other site 693982009882 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693982009883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982009884 dimer interface [polypeptide binding]; other site 693982009885 conserved gate region; other site 693982009886 putative PBP binding loops; other site 693982009887 ABC-ATPase subunit interface; other site 693982009888 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982009889 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982009890 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 693982009891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982009892 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982009893 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982009894 Protein of unknown function (DUF993); Region: DUF993; pfam06187 693982009895 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 693982009896 metal binding site [ion binding]; metal-binding site 693982009897 substrate binding pocket [chemical binding]; other site 693982009898 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693982009899 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 693982009900 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982009901 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982009902 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982009903 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693982009904 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 693982009905 metal-binding site [ion binding] 693982009906 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693982009907 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 693982009908 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982009909 Walker A/P-loop; other site 693982009910 ATP binding site [chemical binding]; other site 693982009911 Q-loop/lid; other site 693982009912 ABC transporter signature motif; other site 693982009913 Walker B; other site 693982009914 D-loop; other site 693982009915 H-loop/switch region; other site 693982009916 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982009917 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982009918 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693982009919 TM-ABC transporter signature motif; other site 693982009920 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982009921 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693982009922 TM-ABC transporter signature motif; other site 693982009923 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 693982009924 active site 693982009925 catalytic motif [active] 693982009926 Zn binding site [ion binding]; other site 693982009927 purine nucleoside phosphorylase; Provisional; Region: PRK08202 693982009928 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 693982009929 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693982009930 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 693982009931 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 693982009932 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693982009933 active site 693982009934 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 693982009935 adenosine deaminase; Provisional; Region: PRK09358 693982009936 active site 693982009937 phosphopentomutase; Provisional; Region: PRK05362 693982009938 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 693982009939 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 693982009940 TadE-like protein; Region: TadE; pfam07811 693982009941 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 693982009942 TadE-like protein; Region: TadE; pfam07811 693982009943 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 693982009944 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 693982009945 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 693982009946 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 693982009947 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 693982009948 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 693982009949 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 693982009950 BON domain; Region: BON; pfam04972 693982009951 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693982009952 Type IV pili component [Cell motility and secretion]; Region: COG5461 693982009953 pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522 693982009954 AAA domain; Region: AAA_31; pfam13614 693982009955 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 693982009956 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693982009957 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 693982009958 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 693982009959 ATP binding site [chemical binding]; other site 693982009960 Walker A motif; other site 693982009961 hexamer interface [polypeptide binding]; other site 693982009962 Walker B motif; other site 693982009963 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 693982009964 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693982009965 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 693982009966 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693982009967 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 693982009968 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 693982009969 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982009970 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 693982009971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982009972 TPR motif; other site 693982009973 binding surface 693982009974 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 693982009975 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 693982009976 interface (dimer of trimers) [polypeptide binding]; other site 693982009977 Substrate-binding/catalytic site; other site 693982009978 Zn-binding sites [ion binding]; other site 693982009979 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693982009980 MarR family; Region: MarR; pfam01047 693982009981 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 693982009982 NlpC/P60 family; Region: NLPC_P60; cl17555 693982009983 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693982009984 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 693982009985 putative ligand binding site [chemical binding]; other site 693982009986 NAD binding site [chemical binding]; other site 693982009987 dimerization interface [polypeptide binding]; other site 693982009988 catalytic site [active] 693982009989 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 693982009990 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982009991 Walker A/P-loop; other site 693982009992 ATP binding site [chemical binding]; other site 693982009993 Q-loop/lid; other site 693982009994 ABC transporter signature motif; other site 693982009995 Walker B; other site 693982009996 D-loop; other site 693982009997 H-loop/switch region; other site 693982009998 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 693982009999 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982010000 Walker A/P-loop; other site 693982010001 ATP binding site [chemical binding]; other site 693982010002 Q-loop/lid; other site 693982010003 ABC transporter signature motif; other site 693982010004 Walker B; other site 693982010005 D-loop; other site 693982010006 H-loop/switch region; other site 693982010007 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982010008 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 693982010009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982010010 dimer interface [polypeptide binding]; other site 693982010011 conserved gate region; other site 693982010012 putative PBP binding loops; other site 693982010013 ABC-ATPase subunit interface; other site 693982010014 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 693982010015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982010016 dimer interface [polypeptide binding]; other site 693982010017 conserved gate region; other site 693982010018 putative PBP binding loops; other site 693982010019 ABC-ATPase subunit interface; other site 693982010020 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 693982010021 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 693982010022 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 693982010023 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 693982010024 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 693982010025 active site 693982010026 dimer interfaces [polypeptide binding]; other site 693982010027 catalytic residues [active] 693982010028 glucokinase; Provisional; Region: glk; PRK00292 693982010029 glucokinase, proteobacterial type; Region: glk; TIGR00749 693982010030 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693982010031 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693982010032 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 693982010033 Walker A/P-loop; other site 693982010034 ATP binding site [chemical binding]; other site 693982010035 Q-loop/lid; other site 693982010036 ABC transporter signature motif; other site 693982010037 Walker B; other site 693982010038 D-loop; other site 693982010039 H-loop/switch region; other site 693982010040 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 693982010041 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 693982010042 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 693982010043 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693982010044 catalytic core [active] 693982010045 Helix-turn-helix domain; Region: HTH_18; pfam12833 693982010046 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 693982010047 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693982010048 DNA binding site [nucleotide binding] 693982010049 active site 693982010050 Integral membrane protein [Function unknown]; Region: COG5488 693982010051 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 693982010052 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693982010053 minor groove reading motif; other site 693982010054 helix-hairpin-helix signature motif; other site 693982010055 substrate binding pocket [chemical binding]; other site 693982010056 active site 693982010057 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 693982010058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982010059 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 693982010060 putative dimer interface [polypeptide binding]; other site 693982010061 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982010062 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 693982010063 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693982010064 substrate binding site [chemical binding]; other site 693982010065 ATP binding site [chemical binding]; other site 693982010066 Predicted kinase [General function prediction only]; Region: COG0645 693982010067 AAA domain; Region: AAA_17; pfam13207 693982010068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 693982010069 Bacterial SH3 domain; Region: SH3_4; pfam06347 693982010070 Bacterial SH3 domain; Region: SH3_4; pfam06347 693982010071 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693982010072 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 693982010073 dimerization interface [polypeptide binding]; other site 693982010074 ligand binding site [chemical binding]; other site 693982010075 NADP binding site [chemical binding]; other site 693982010076 catalytic site [active] 693982010077 5'-3' exonuclease; Region: 53EXOc; smart00475 693982010078 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 693982010079 active site 693982010080 metal binding site 1 [ion binding]; metal-binding site 693982010081 putative 5' ssDNA interaction site; other site 693982010082 metal binding site 3; metal-binding site 693982010083 metal binding site 2 [ion binding]; metal-binding site 693982010084 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 693982010085 putative DNA binding site [nucleotide binding]; other site 693982010086 putative metal binding site [ion binding]; other site 693982010087 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 693982010088 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 693982010089 active site 693982010090 catalytic site [active] 693982010091 substrate binding site [chemical binding]; other site 693982010092 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 693982010093 active site 693982010094 DNA binding site [nucleotide binding] 693982010095 catalytic site [active] 693982010096 MarR family; Region: MarR; pfam01047 693982010097 hypothetical protein; Validated; Region: PRK09104 693982010098 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 693982010099 metal binding site [ion binding]; metal-binding site 693982010100 putative dimer interface [polypeptide binding]; other site 693982010101 Predicted integral membrane protein [Function unknown]; Region: COG0392 693982010102 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693982010103 EamA-like transporter family; Region: EamA; pfam00892 693982010104 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 693982010105 Transglycosylase; Region: Transgly; pfam00912 693982010106 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693982010107 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 693982010108 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 693982010109 nucleotide binding site [chemical binding]; other site 693982010110 NEF interaction site [polypeptide binding]; other site 693982010111 SBD interface [polypeptide binding]; other site 693982010112 chaperone protein DnaJ; Provisional; Region: PRK10767 693982010113 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693982010114 HSP70 interaction site [polypeptide binding]; other site 693982010115 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 693982010116 substrate binding site [polypeptide binding]; other site 693982010117 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 693982010118 Zn binding sites [ion binding]; other site 693982010119 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 693982010120 dimer interface [polypeptide binding]; other site 693982010121 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 693982010122 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 693982010123 Uncharacterized conserved protein [Function unknown]; Region: COG5588 693982010124 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693982010125 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 693982010126 recombination protein F; Reviewed; Region: recF; PRK00064 693982010127 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 693982010128 Walker A/P-loop; other site 693982010129 ATP binding site [chemical binding]; other site 693982010130 Q-loop/lid; other site 693982010131 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982010132 ABC transporter signature motif; other site 693982010133 Walker B; other site 693982010134 D-loop; other site 693982010135 H-loop/switch region; other site 693982010136 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 693982010137 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 693982010138 ATP binding site [chemical binding]; other site 693982010139 substrate interface [chemical binding]; other site 693982010140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982010141 Coenzyme A binding pocket [chemical binding]; other site 693982010142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982010143 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 693982010144 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 693982010145 Protein export membrane protein; Region: SecD_SecF; cl14618 693982010146 Protein export membrane protein; Region: SecD_SecF; cl14618 693982010147 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 693982010148 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982010149 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982010150 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982010151 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982010152 Walker A/P-loop; other site 693982010153 ATP binding site [chemical binding]; other site 693982010154 Q-loop/lid; other site 693982010155 ABC transporter signature motif; other site 693982010156 Walker B; other site 693982010157 D-loop; other site 693982010158 H-loop/switch region; other site 693982010159 TOBE domain; Region: TOBE_2; pfam08402 693982010160 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982010161 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982010162 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982010163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982010164 dimer interface [polypeptide binding]; other site 693982010165 conserved gate region; other site 693982010166 putative PBP binding loops; other site 693982010167 ABC-ATPase subunit interface; other site 693982010168 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982010169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982010170 dimer interface [polypeptide binding]; other site 693982010171 conserved gate region; other site 693982010172 putative PBP binding loops; other site 693982010173 ABC-ATPase subunit interface; other site 693982010174 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982010175 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982010176 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 693982010177 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 693982010178 putative active site [active] 693982010179 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 693982010180 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693982010181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982010182 DNA-binding site [nucleotide binding]; DNA binding site 693982010183 UTRA domain; Region: UTRA; pfam07702 693982010184 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 693982010185 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 693982010186 dimer interface [polypeptide binding]; other site 693982010187 active site 693982010188 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 693982010189 dimer interface [polypeptide binding]; other site 693982010190 active site 693982010191 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 693982010192 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 693982010193 active site 693982010194 dimer interface [polypeptide binding]; other site 693982010195 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 693982010196 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693982010197 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693982010198 hypothetical protein; Provisional; Region: PRK06102 693982010199 Amidase; Region: Amidase; cl11426 693982010200 CysZ-like protein; Reviewed; Region: PRK12768 693982010201 hypothetical protein; Provisional; Region: PRK00736 693982010202 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 693982010203 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 693982010204 ligand binding site [chemical binding]; other site 693982010205 methionine sulfoxide reductase A; Provisional; Region: PRK00058 693982010206 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 693982010207 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693982010208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982010209 muropeptide transporter; Validated; Region: ampG; cl17669 693982010210 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693982010211 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693982010212 N-terminal plug; other site 693982010213 ligand-binding site [chemical binding]; other site 693982010214 hypothetical protein; Provisional; Region: PRK07588 693982010215 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693982010216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982010217 putative substrate translocation pore; other site 693982010218 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693982010219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982010220 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982010221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982010222 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 693982010223 putative substrate binding pocket [chemical binding]; other site 693982010224 putative dimerization interface [polypeptide binding]; other site 693982010225 BON domain; Region: BON; cl02771 693982010226 Predicted permeases [General function prediction only]; Region: COG0679 693982010227 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 693982010228 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 693982010229 homodimer interface [polypeptide binding]; other site 693982010230 substrate-cofactor binding pocket; other site 693982010231 catalytic residue [active] 693982010232 Cytochrome c2 [Energy production and conversion]; Region: COG3474 693982010233 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 693982010234 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 693982010235 Ligand binding site; other site 693982010236 oligomer interface; other site 693982010237 prephenate dehydratase; Provisional; Region: PRK11899 693982010238 Prephenate dehydratase; Region: PDT; pfam00800 693982010239 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 693982010240 putative L-Phe binding site [chemical binding]; other site 693982010241 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 693982010242 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 693982010243 putative dimer interface [polypeptide binding]; other site 693982010244 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982010245 Predicted transcriptional regulator [Transcription]; Region: COG2378 693982010246 HTH domain; Region: HTH_11; pfam08279 693982010247 WYL domain; Region: WYL; pfam13280 693982010248 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 693982010249 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 693982010250 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 693982010251 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 693982010252 putative NADH binding site [chemical binding]; other site 693982010253 putative active site [active] 693982010254 nudix motif; other site 693982010255 putative metal binding site [ion binding]; other site 693982010256 HIT domain; Region: HIT; pfam01230 693982010257 nucleotide binding site/active site [active] 693982010258 HIT family signature motif; other site 693982010259 catalytic residue [active] 693982010260 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 693982010261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982010262 Walker A motif; other site 693982010263 ATP binding site [chemical binding]; other site 693982010264 Walker B motif; other site 693982010265 arginine finger; other site 693982010266 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 693982010267 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 693982010268 hypothetical protein; Validated; Region: PRK00153 693982010269 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693982010270 recombination protein RecR; Reviewed; Region: recR; PRK00076 693982010271 RecR protein; Region: RecR; pfam02132 693982010272 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 693982010273 putative active site [active] 693982010274 putative metal-binding site [ion binding]; other site 693982010275 tetramer interface [polypeptide binding]; other site 693982010276 Transglycosylase SLT domain; Region: SLT_2; pfam13406 693982010277 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693982010278 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693982010279 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982010280 Transmembrane secretion effector; Region: MFS_3; pfam05977 693982010281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982010282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982010283 ribosome maturation protein RimP; Reviewed; Region: PRK00092 693982010284 Sm and related proteins; Region: Sm_like; cl00259 693982010285 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 693982010286 putative oligomer interface [polypeptide binding]; other site 693982010287 putative RNA binding site [nucleotide binding]; other site 693982010288 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 693982010289 NusA N-terminal domain; Region: NusA_N; pfam08529 693982010290 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 693982010291 RNA binding site [nucleotide binding]; other site 693982010292 homodimer interface [polypeptide binding]; other site 693982010293 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 693982010294 G-X-X-G motif; other site 693982010295 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 693982010296 G-X-X-G motif; other site 693982010297 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 693982010298 hypothetical protein; Provisional; Region: PRK09190 693982010299 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 693982010300 putative RNA binding cleft [nucleotide binding]; other site 693982010301 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 693982010302 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 693982010303 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 693982010304 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 693982010305 G1 box; other site 693982010306 putative GEF interaction site [polypeptide binding]; other site 693982010307 GTP/Mg2+ binding site [chemical binding]; other site 693982010308 Switch I region; other site 693982010309 G2 box; other site 693982010310 G3 box; other site 693982010311 Switch II region; other site 693982010312 G4 box; other site 693982010313 G5 box; other site 693982010314 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 693982010315 Translation-initiation factor 2; Region: IF-2; pfam11987 693982010316 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 693982010317 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 693982010318 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 693982010319 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 693982010320 RNA binding site [nucleotide binding]; other site 693982010321 active site 693982010322 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 693982010323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 693982010324 HWE histidine kinase; Region: HWE_HK; pfam07536 693982010325 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 693982010326 16S/18S rRNA binding site [nucleotide binding]; other site 693982010327 S13e-L30e interaction site [polypeptide binding]; other site 693982010328 25S rRNA binding site [nucleotide binding]; other site 693982010329 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 693982010330 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 693982010331 RNase E interface [polypeptide binding]; other site 693982010332 trimer interface [polypeptide binding]; other site 693982010333 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 693982010334 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 693982010335 RNase E interface [polypeptide binding]; other site 693982010336 trimer interface [polypeptide binding]; other site 693982010337 active site 693982010338 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 693982010339 putative nucleic acid binding region [nucleotide binding]; other site 693982010340 G-X-X-G motif; other site 693982010341 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 693982010342 RNA binding site [nucleotide binding]; other site 693982010343 domain interface; other site 693982010344 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 693982010345 Methyltransferase small domain; Region: MTS; pfam05175 693982010346 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 693982010347 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 693982010348 NAD binding site [chemical binding]; other site 693982010349 homotetramer interface [polypeptide binding]; other site 693982010350 homodimer interface [polypeptide binding]; other site 693982010351 substrate binding site [chemical binding]; other site 693982010352 active site 693982010353 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 693982010354 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693982010355 dimer interface [polypeptide binding]; other site 693982010356 active site 693982010357 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 693982010358 active site 1 [active] 693982010359 dimer interface [polypeptide binding]; other site 693982010360 active site 2 [active] 693982010361 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 693982010362 metal binding site 2 [ion binding]; metal-binding site 693982010363 putative DNA binding helix; other site 693982010364 metal binding site 1 [ion binding]; metal-binding site 693982010365 dimer interface [polypeptide binding]; other site 693982010366 Predicted membrane protein [Function unknown]; Region: COG2860 693982010367 UPF0126 domain; Region: UPF0126; pfam03458 693982010368 UPF0126 domain; Region: UPF0126; pfam03458 693982010369 Uncharacterized conserved protein [Function unknown]; Region: COG1434 693982010370 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693982010371 putative active site [active] 693982010372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 693982010373 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 693982010374 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 693982010375 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 693982010376 hinge; other site 693982010377 active site 693982010378 cytidylate kinase; Provisional; Region: cmk; PRK00023 693982010379 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 693982010380 CMP-binding site; other site 693982010381 The sites determining sugar specificity; other site 693982010382 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 693982010383 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 693982010384 RNA binding site [nucleotide binding]; other site 693982010385 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 693982010386 RNA binding site [nucleotide binding]; other site 693982010387 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 693982010388 RNA binding site [nucleotide binding]; other site 693982010389 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693982010390 RNA binding site [nucleotide binding]; other site 693982010391 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693982010392 RNA binding site [nucleotide binding]; other site 693982010393 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 693982010394 RNA binding site [nucleotide binding]; other site 693982010395 BA14K-like protein; Region: BA14K; pfam07886 693982010396 Cache domain; Region: Cache_1; pfam02743 693982010397 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 693982010398 dimerization interface [polypeptide binding]; other site 693982010399 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982010400 cyclase homology domain; Region: CHD; cd07302 693982010401 nucleotidyl binding site; other site 693982010402 metal binding site [ion binding]; metal-binding site 693982010403 dimer interface [polypeptide binding]; other site 693982010404 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693982010405 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 693982010406 putative ligand binding site [chemical binding]; other site 693982010407 putative NAD binding site [chemical binding]; other site 693982010408 catalytic site [active] 693982010409 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 693982010410 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 693982010411 catalytic site [active] 693982010412 putative active site [active] 693982010413 putative substrate binding site [chemical binding]; other site 693982010414 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982010415 Winged helix-turn helix; Region: HTH_29; pfam13551 693982010416 Homeodomain-like domain; Region: HTH_32; pfam13565 693982010417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693982010418 Integrase core domain; Region: rve; pfam00665 693982010419 Integrase core domain; Region: rve_3; pfam13683 693982010420 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 693982010421 GIY-YIG motif/motif A; other site 693982010422 putative active site [active] 693982010423 putative metal binding site [ion binding]; other site 693982010424 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 693982010425 Predicted membrane protein [Function unknown]; Region: COG2259 693982010426 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 693982010427 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693982010428 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 693982010429 GTP-binding protein LepA; Provisional; Region: PRK05433 693982010430 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 693982010431 G1 box; other site 693982010432 putative GEF interaction site [polypeptide binding]; other site 693982010433 GTP/Mg2+ binding site [chemical binding]; other site 693982010434 Switch I region; other site 693982010435 G2 box; other site 693982010436 G3 box; other site 693982010437 Switch II region; other site 693982010438 G4 box; other site 693982010439 G5 box; other site 693982010440 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 693982010441 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 693982010442 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 693982010443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982010444 putative substrate translocation pore; other site 693982010445 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982010446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982010447 sequence-specific DNA binding site [nucleotide binding]; other site 693982010448 salt bridge; other site 693982010449 Cupin domain; Region: Cupin_2; pfam07883 693982010450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982010451 Coenzyme A binding pocket [chemical binding]; other site 693982010452 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 693982010453 putative outer membrane lipoprotein; Provisional; Region: PRK10510 693982010454 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693982010455 ligand binding site [chemical binding]; other site 693982010456 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 693982010457 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693982010458 FeS/SAM binding site; other site 693982010459 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 693982010460 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693982010461 motif 1; other site 693982010462 dimer interface [polypeptide binding]; other site 693982010463 active site 693982010464 motif 2; other site 693982010465 motif 3; other site 693982010466 elongation factor P; Validated; Region: PRK00529 693982010467 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 693982010468 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 693982010469 RNA binding site [nucleotide binding]; other site 693982010470 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 693982010471 RNA binding site [nucleotide binding]; other site 693982010472 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 693982010473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693982010474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982010475 S-adenosylmethionine binding site [chemical binding]; other site 693982010476 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 693982010477 diiron binding motif [ion binding]; other site 693982010478 Uncharacterized conserved protein [Function unknown]; Region: COG1633 693982010479 CCC1-related protein family; Region: CCC1_like_1; cd02437 693982010480 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 693982010481 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693982010482 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 693982010483 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 693982010484 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 693982010485 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 693982010486 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 693982010487 23S rRNA binding site [nucleotide binding]; other site 693982010488 L21 binding site [polypeptide binding]; other site 693982010489 L13 binding site [polypeptide binding]; other site 693982010490 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 693982010491 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 693982010492 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 693982010493 dimer interface [polypeptide binding]; other site 693982010494 motif 1; other site 693982010495 active site 693982010496 motif 2; other site 693982010497 motif 3; other site 693982010498 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 693982010499 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 693982010500 putative tRNA-binding site [nucleotide binding]; other site 693982010501 B3/4 domain; Region: B3_4; pfam03483 693982010502 tRNA synthetase B5 domain; Region: B5; smart00874 693982010503 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 693982010504 dimer interface [polypeptide binding]; other site 693982010505 motif 1; other site 693982010506 motif 3; other site 693982010507 motif 2; other site 693982010508 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 693982010509 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 693982010510 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982010511 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982010512 active site 693982010513 catalytic tetrad [active] 693982010514 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982010515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982010516 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 693982010517 putative effector binding pocket; other site 693982010518 putative dimerization interface [polypeptide binding]; other site 693982010519 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 693982010520 dimerization interface [polypeptide binding]; other site 693982010521 metal binding site [ion binding]; metal-binding site 693982010522 short chain dehydrogenase; Provisional; Region: PRK07478 693982010523 classical (c) SDRs; Region: SDR_c; cd05233 693982010524 NAD(P) binding site [chemical binding]; other site 693982010525 active site 693982010526 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982010527 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982010528 active site 693982010529 catalytic tetrad [active] 693982010530 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982010531 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982010532 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982010533 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982010534 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982010535 non-specific DNA binding site [nucleotide binding]; other site 693982010536 salt bridge; other site 693982010537 sequence-specific DNA binding site [nucleotide binding]; other site 693982010538 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 693982010539 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 693982010540 generic binding surface II; other site 693982010541 generic binding surface I; other site 693982010542 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 693982010543 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693982010544 MarR family; Region: MarR_2; cl17246 693982010545 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693982010546 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693982010547 EamA-like transporter family; Region: EamA; pfam00892 693982010548 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 693982010549 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 693982010550 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982010551 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 693982010552 C-terminal domain interface [polypeptide binding]; other site 693982010553 GSH binding site (G-site) [chemical binding]; other site 693982010554 dimer interface [polypeptide binding]; other site 693982010555 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 693982010556 N-terminal domain interface [polypeptide binding]; other site 693982010557 dimer interface [polypeptide binding]; other site 693982010558 substrate binding pocket (H-site) [chemical binding]; other site 693982010559 MarR family; Region: MarR_2; pfam12802 693982010560 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693982010561 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 693982010562 putative deacylase active site [active] 693982010563 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 693982010564 ArsC family; Region: ArsC; pfam03960 693982010565 putative catalytic residues [active] 693982010566 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 693982010567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982010568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982010569 homodimer interface [polypeptide binding]; other site 693982010570 catalytic residue [active] 693982010571 Predicted deacylase [General function prediction only]; Region: COG3608 693982010572 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 693982010573 active site 693982010574 Zn binding site [ion binding]; other site 693982010575 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 693982010576 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 693982010577 putative active site [active] 693982010578 GMP synthase; Reviewed; Region: guaA; PRK00074 693982010579 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 693982010580 AMP/PPi binding site [chemical binding]; other site 693982010581 candidate oxyanion hole; other site 693982010582 catalytic triad [active] 693982010583 potential glutamine specificity residues [chemical binding]; other site 693982010584 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 693982010585 ATP Binding subdomain [chemical binding]; other site 693982010586 Ligand Binding sites [chemical binding]; other site 693982010587 Dimerization subdomain; other site 693982010588 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 693982010589 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 693982010590 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693982010591 CoenzymeA binding site [chemical binding]; other site 693982010592 subunit interaction site [polypeptide binding]; other site 693982010593 PHB binding site; other site 693982010594 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693982010595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982010596 Coenzyme A binding pocket [chemical binding]; other site 693982010597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 693982010598 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 693982010599 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982010600 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 693982010601 Transposase [DNA replication, recombination, and repair]; Region: COG5433 693982010602 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 693982010603 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 693982010604 Cl binding site [ion binding]; other site 693982010605 oligomer interface [polypeptide binding]; other site 693982010606 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG3489 693982010607 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 693982010608 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 693982010609 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 693982010610 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 693982010611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982010612 S-adenosylmethionine binding site [chemical binding]; other site 693982010613 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 693982010614 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 693982010615 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982010616 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 693982010617 putative NAD(P) binding site [chemical binding]; other site 693982010618 epoxyqueuosine reductase; Region: TIGR00276 693982010619 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 693982010620 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982010621 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 693982010622 C-terminal domain interface [polypeptide binding]; other site 693982010623 GSH binding site (G-site) [chemical binding]; other site 693982010624 dimer interface [polypeptide binding]; other site 693982010625 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 693982010626 N-terminal domain interface [polypeptide binding]; other site 693982010627 dimer interface [polypeptide binding]; other site 693982010628 substrate binding pocket (H-site) [chemical binding]; other site 693982010629 Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968 693982010630 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 693982010631 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 693982010632 putative NAD(P) binding site [chemical binding]; other site 693982010633 active site 693982010634 Uncharacterized conserved protein [Function unknown]; Region: COG5470 693982010635 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 693982010636 active site 693982010637 dimer interface [polypeptide binding]; other site 693982010638 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693982010639 catalytic core [active] 693982010640 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693982010641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982010642 S-adenosylmethionine binding site [chemical binding]; other site 693982010643 DNA polymerase III subunit beta; Validated; Region: PRK05643 693982010644 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 693982010645 putative DNA binding surface [nucleotide binding]; other site 693982010646 dimer interface [polypeptide binding]; other site 693982010647 beta-clamp/clamp loader binding surface; other site 693982010648 beta-clamp/translesion DNA polymerase binding surface; other site 693982010649 Predicted methyltransferases [General function prediction only]; Region: COG0313 693982010650 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 693982010651 putative SAM binding site [chemical binding]; other site 693982010652 putative homodimer interface [polypeptide binding]; other site 693982010653 hypothetical protein; Reviewed; Region: PRK12497 693982010654 glutathione synthetase; Provisional; Region: PRK05246 693982010655 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 693982010656 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 693982010657 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 693982010658 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 693982010659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982010660 Walker A motif; other site 693982010661 ATP binding site [chemical binding]; other site 693982010662 Walker B motif; other site 693982010663 arginine finger; other site 693982010664 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 693982010665 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 693982010666 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 693982010667 dimer interface [polypeptide binding]; other site 693982010668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982010669 catalytic residue [active] 693982010670 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693982010671 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693982010672 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693982010673 EamA-like transporter family; Region: EamA; pfam00892 693982010674 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982010675 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982010676 putative DNA binding site [nucleotide binding]; other site 693982010677 putative Zn2+ binding site [ion binding]; other site 693982010678 AsnC family; Region: AsnC_trans_reg; pfam01037 693982010679 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 693982010680 trimer interface [polypeptide binding]; other site 693982010681 active site 693982010682 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 693982010683 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 693982010684 G1 box; other site 693982010685 putative GEF interaction site [polypeptide binding]; other site 693982010686 GTP/Mg2+ binding site [chemical binding]; other site 693982010687 Switch I region; other site 693982010688 G2 box; other site 693982010689 G3 box; other site 693982010690 Switch II region; other site 693982010691 G4 box; other site 693982010692 G5 box; other site 693982010693 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 693982010694 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693982010695 EamA-like transporter family; Region: EamA; pfam00892 693982010696 EamA-like transporter family; Region: EamA; pfam00892 693982010697 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693982010698 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693982010699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982010700 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982010701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982010702 NAD(P) binding site [chemical binding]; other site 693982010703 active site 693982010704 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693982010705 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 693982010706 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693982010707 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 693982010708 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693982010709 dimer interface [polypeptide binding]; other site 693982010710 PYR/PP interface [polypeptide binding]; other site 693982010711 TPP binding site [chemical binding]; other site 693982010712 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693982010713 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 693982010714 TPP-binding site [chemical binding]; other site 693982010715 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693982010716 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 693982010717 substrate binding site [chemical binding]; other site 693982010718 ATP binding site [chemical binding]; other site 693982010719 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 693982010720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 693982010721 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693982010722 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693982010723 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693982010724 putative active site [active] 693982010725 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982010726 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982010727 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982010728 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 693982010729 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 693982010730 putative active site [active] 693982010731 putative dimer interface [polypeptide binding]; other site 693982010732 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 693982010733 Flavoprotein; Region: Flavoprotein; pfam02441 693982010734 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 693982010735 Predicted transcriptional regulator [Transcription]; Region: COG1959 693982010736 Transcriptional regulator; Region: Rrf2; pfam02082 693982010737 Transcriptional regulator; Region: Rrf2; cl17282 693982010738 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 693982010739 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 693982010740 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 693982010741 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 693982010742 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 693982010743 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693982010744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982010745 NAD(P) binding site [chemical binding]; other site 693982010746 active site 693982010747 ABC1 family; Region: ABC1; cl17513 693982010748 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 693982010749 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 693982010750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982010751 S-adenosylmethionine binding site [chemical binding]; other site 693982010752 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 693982010753 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 693982010754 DNA binding site [nucleotide binding] 693982010755 catalytic residue [active] 693982010756 H2TH interface [polypeptide binding]; other site 693982010757 putative catalytic residues [active] 693982010758 turnover-facilitating residue; other site 693982010759 intercalation triad [nucleotide binding]; other site 693982010760 8OG recognition residue [nucleotide binding]; other site 693982010761 putative reading head residues; other site 693982010762 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 693982010763 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 693982010764 enoyl-CoA hydratase; Provisional; Region: PRK05862 693982010765 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693982010766 substrate binding site [chemical binding]; other site 693982010767 oxyanion hole (OAH) forming residues; other site 693982010768 trimer interface [polypeptide binding]; other site 693982010769 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 693982010770 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 693982010771 active sites [active] 693982010772 tetramer interface [polypeptide binding]; other site 693982010773 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693982010774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982010775 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693982010776 dimerization interface [polypeptide binding]; other site 693982010777 substrate binding pocket [chemical binding]; other site 693982010778 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982010779 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 693982010780 Cupin domain; Region: Cupin_2; cl17218 693982010781 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982010782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982010783 conserved gate region; other site 693982010784 dimer interface [polypeptide binding]; other site 693982010785 putative PBP binding loops; other site 693982010786 ABC-ATPase subunit interface; other site 693982010787 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982010788 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 693982010789 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 693982010790 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982010791 Walker A/P-loop; other site 693982010792 ATP binding site [chemical binding]; other site 693982010793 Q-loop/lid; other site 693982010794 ABC transporter signature motif; other site 693982010795 Walker B; other site 693982010796 D-loop; other site 693982010797 H-loop/switch region; other site 693982010798 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 693982010799 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 693982010800 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982010801 Walker A/P-loop; other site 693982010802 ATP binding site [chemical binding]; other site 693982010803 Q-loop/lid; other site 693982010804 ABC transporter signature motif; other site 693982010805 Walker B; other site 693982010806 D-loop; other site 693982010807 H-loop/switch region; other site 693982010808 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982010809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 693982010810 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693982010811 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 693982010812 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 693982010813 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 693982010814 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 693982010815 RibD C-terminal domain; Region: RibD_C; cl17279 693982010816 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693982010817 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 693982010818 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982010819 Homeodomain-like domain; Region: HTH_32; pfam13565 693982010820 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693982010821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693982010822 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 693982010823 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 693982010824 DNA binding residues [nucleotide binding] 693982010825 dimerization interface [polypeptide binding]; other site 693982010826 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 693982010827 Moco binding site; other site 693982010828 metal coordination site [ion binding]; other site 693982010829 dimerization interface [polypeptide binding]; other site 693982010830 Predicted periplasmic protein [Function unknown]; Region: COG3904 693982010831 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982010832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982010833 DNA binding site [nucleotide binding] 693982010834 Predicted ATPase [General function prediction only]; Region: COG3903 693982010835 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 693982010836 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693982010837 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693982010838 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693982010839 Predicted membrane protein [Function unknown]; Region: COG3918 693982010840 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 693982010841 classical (c) SDRs; Region: SDR_c; cd05233 693982010842 NAD(P) binding site [chemical binding]; other site 693982010843 active site 693982010844 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693982010845 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693982010846 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982010847 cyclase homology domain; Region: CHD; cd07302 693982010848 nucleotidyl binding site; other site 693982010849 metal binding site [ion binding]; metal-binding site 693982010850 dimer interface [polypeptide binding]; other site 693982010851 Predicted integral membrane protein [Function unknown]; Region: COG5616 693982010852 TPR repeat; Region: TPR_11; pfam13414 693982010853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982010854 binding surface 693982010855 TPR motif; other site 693982010856 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982010857 cyclase homology domain; Region: CHD; cd07302 693982010858 nucleotidyl binding site; other site 693982010859 metal binding site [ion binding]; metal-binding site 693982010860 dimer interface [polypeptide binding]; other site 693982010861 Predicted integral membrane protein [Function unknown]; Region: COG5616 693982010862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982010863 TPR motif; other site 693982010864 binding surface 693982010865 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 693982010866 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 693982010867 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 693982010868 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982010869 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982010870 active site 693982010871 catalytic tetrad [active] 693982010872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4334 693982010873 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 693982010874 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 693982010875 Uncharacterized conserved protein [Function unknown]; Region: COG1359 693982010876 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982010877 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982010878 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 693982010879 putative effector binding pocket; other site 693982010880 putative dimerization interface [polypeptide binding]; other site 693982010881 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 693982010882 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 693982010883 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 693982010884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982010885 active site 693982010886 phosphorylation site [posttranslational modification] 693982010887 intermolecular recognition site; other site 693982010888 dimerization interface [polypeptide binding]; other site 693982010889 putative integral membrane protein TIGR02587; Region: TIGR02587 693982010890 TIGR02588 family protein; Region: TIGR02588 693982010891 Protein of unknown function (DUF433); Region: DUF433; pfam04255 693982010892 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 693982010893 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 693982010894 DNA binding residues [nucleotide binding] 693982010895 dimer interface [polypeptide binding]; other site 693982010896 mercury binding site [ion binding]; other site 693982010897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982010898 S-adenosylmethionine binding site [chemical binding]; other site 693982010899 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 693982010900 intracellular protease, PfpI family; Region: PfpI; TIGR01382 693982010901 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 693982010902 conserved cys residue [active] 693982010903 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982010904 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 693982010905 putative ligand binding site [chemical binding]; other site 693982010906 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982010907 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982010908 TM-ABC transporter signature motif; other site 693982010909 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982010910 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982010911 Walker A/P-loop; other site 693982010912 ATP binding site [chemical binding]; other site 693982010913 Q-loop/lid; other site 693982010914 ABC transporter signature motif; other site 693982010915 Walker B; other site 693982010916 D-loop; other site 693982010917 H-loop/switch region; other site 693982010918 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982010919 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982010920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982010921 DNA-binding site [nucleotide binding]; DNA binding site 693982010922 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693982010923 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 693982010924 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 693982010925 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 693982010926 active site 693982010927 NAD binding site [chemical binding]; other site 693982010928 metal binding site [ion binding]; metal-binding site 693982010929 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693982010930 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 693982010931 tetramerization interface [polypeptide binding]; other site 693982010932 NAD(P) binding site [chemical binding]; other site 693982010933 catalytic residues [active] 693982010934 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 693982010935 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 693982010936 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 693982010937 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 693982010938 FMN binding site [chemical binding]; other site 693982010939 active site 693982010940 homodimer interface [polypeptide binding]; other site 693982010941 putative catalytic residue [active] 693982010942 4Fe-4S cluster binding site [ion binding]; other site 693982010943 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693982010944 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 693982010945 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 693982010946 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 693982010947 active site 693982010948 catalytic site [active] 693982010949 substrate binding site [chemical binding]; other site 693982010950 Uncharacterized conserved protein [Function unknown]; Region: COG5482 693982010951 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693982010952 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 693982010953 DctM-like transporters; Region: DctM; pfam06808 693982010954 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693982010955 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693982010956 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 693982010957 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693982010958 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982010959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982010960 DNA-binding site [nucleotide binding]; DNA binding site 693982010961 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693982010962 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693982010963 FAD binding domain; Region: FAD_binding_4; pfam01565 693982010964 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982010965 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 693982010966 putative NAD(P) binding site [chemical binding]; other site 693982010967 active site 693982010968 putative substrate binding site [chemical binding]; other site 693982010969 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 693982010970 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693982010971 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 693982010972 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 693982010973 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 693982010974 active site 693982010975 homotetramer interface [polypeptide binding]; other site 693982010976 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 693982010977 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 693982010978 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693982010979 glutamate dehydrogenase; Provisional; Region: PRK09414 693982010980 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 693982010981 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 693982010982 NAD(P) binding site [chemical binding]; other site 693982010983 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 693982010984 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 693982010985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982010986 putative substrate translocation pore; other site 693982010987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982010988 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982010989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982010990 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982010991 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982010992 DNA-binding site [nucleotide binding]; DNA binding site 693982010993 FCD domain; Region: FCD; pfam07729 693982010994 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693982010995 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 693982010996 NAD(P) binding site [chemical binding]; other site 693982010997 catalytic residues [active] 693982010998 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693982010999 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693982011000 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982011001 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982011002 TM-ABC transporter signature motif; other site 693982011003 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 693982011004 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982011005 Walker A/P-loop; other site 693982011006 ATP binding site [chemical binding]; other site 693982011007 Q-loop/lid; other site 693982011008 ABC transporter signature motif; other site 693982011009 Walker B; other site 693982011010 D-loop; other site 693982011011 H-loop/switch region; other site 693982011012 5-keto 4-deoxyuronate isomerase [Carbohydrate transport and metabolism]; Region: KduI; COG3717 693982011013 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982011014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982011015 active site 693982011016 phosphorylation site [posttranslational modification] 693982011017 intermolecular recognition site; other site 693982011018 dimerization interface [polypeptide binding]; other site 693982011019 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 693982011020 DNA binding residues [nucleotide binding] 693982011021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 693982011022 Histidine kinase; Region: HisKA_3; pfam07730 693982011023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982011024 ATP binding site [chemical binding]; other site 693982011025 Mg2+ binding site [ion binding]; other site 693982011026 G-X-G motif; other site 693982011027 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982011028 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 693982011029 putative ligand binding site [chemical binding]; other site 693982011030 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982011031 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982011032 Walker A/P-loop; other site 693982011033 ATP binding site [chemical binding]; other site 693982011034 Q-loop/lid; other site 693982011035 ABC transporter signature motif; other site 693982011036 Walker B; other site 693982011037 D-loop; other site 693982011038 H-loop/switch region; other site 693982011039 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982011040 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982011041 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982011042 TM-ABC transporter signature motif; other site 693982011043 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982011044 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982011045 TM-ABC transporter signature motif; other site 693982011046 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 693982011047 Strictosidine synthase; Region: Str_synth; pfam03088 693982011048 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982011049 dimerization interface [polypeptide binding]; other site 693982011050 putative DNA binding site [nucleotide binding]; other site 693982011051 putative Zn2+ binding site [ion binding]; other site 693982011052 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 693982011053 putative hydrophobic ligand binding site [chemical binding]; other site 693982011054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982011055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982011056 short chain dehydrogenase; Provisional; Region: PRK06701 693982011057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982011058 NAD(P) binding site [chemical binding]; other site 693982011059 active site 693982011060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982011061 putative substrate translocation pore; other site 693982011062 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693982011063 DNA-binding site [nucleotide binding]; DNA binding site 693982011064 RNA-binding motif; other site 693982011065 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 693982011066 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693982011067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982011068 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982011069 dimerization interface [polypeptide binding]; other site 693982011070 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693982011071 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 693982011072 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982011073 cyclase homology domain; Region: CHD; cd07302 693982011074 nucleotidyl binding site; other site 693982011075 metal binding site [ion binding]; metal-binding site 693982011076 dimer interface [polypeptide binding]; other site 693982011077 Predicted integral membrane protein [Function unknown]; Region: COG5616 693982011078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982011079 binding surface 693982011080 TPR motif; other site 693982011081 GYD domain; Region: GYD; pfam08734 693982011082 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693982011083 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693982011084 Uncharacterized conserved protein [Function unknown]; Region: COG2326 693982011085 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 693982011086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982011087 S-adenosylmethionine binding site [chemical binding]; other site 693982011088 hypothetical protein; Provisional; Region: PRK08317 693982011089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982011090 S-adenosylmethionine binding site [chemical binding]; other site 693982011091 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 693982011092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982011093 binding surface 693982011094 TPR motif; other site 693982011095 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 693982011096 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 693982011097 BON domain; Region: BON; pfam04972 693982011098 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693982011099 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982011100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982011101 DNA-binding site [nucleotide binding]; DNA binding site 693982011102 FCD domain; Region: FCD; pfam07729 693982011103 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693982011104 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 693982011105 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693982011106 DctM-like transporters; Region: DctM; pfam06808 693982011107 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693982011108 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 693982011109 malonyl-CoA synthase; Validated; Region: PRK07514 693982011110 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 693982011111 acyl-activating enzyme (AAE) consensus motif; other site 693982011112 active site 693982011113 AMP binding site [chemical binding]; other site 693982011114 CoA binding site [chemical binding]; other site 693982011115 transcription elongation factor regulatory protein; Validated; Region: PRK06342 693982011116 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693982011117 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 693982011118 RNA polymerase sigma factor; Provisional; Region: PRK12547 693982011119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982011120 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982011121 DNA binding residues [nucleotide binding] 693982011122 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 693982011123 active site 693982011124 catalytic triad [active] 693982011125 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 693982011126 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693982011127 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982011128 metal binding site [ion binding]; metal-binding site 693982011129 active site 693982011130 I-site; other site 693982011131 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693982011132 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693982011133 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693982011134 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 693982011135 Fatty acid desaturase; Region: FA_desaturase; pfam00487 693982011136 putative di-iron ligands [ion binding]; other site 693982011137 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693982011138 DNA-binding site [nucleotide binding]; DNA binding site 693982011139 RNA-binding motif; other site 693982011140 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 693982011141 oligomerisation interface [polypeptide binding]; other site 693982011142 mobile loop; other site 693982011143 roof hairpin; other site 693982011144 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 693982011145 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 693982011146 ring oligomerisation interface [polypeptide binding]; other site 693982011147 ATP/Mg binding site [chemical binding]; other site 693982011148 stacking interactions; other site 693982011149 hinge regions; other site 693982011150 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693982011151 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 693982011152 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 693982011153 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693982011154 HSP70 interaction site [polypeptide binding]; other site 693982011155 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 693982011156 substrate binding site [polypeptide binding]; other site 693982011157 dimer interface [polypeptide binding]; other site 693982011158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982011159 active site 693982011160 phosphorylation site [posttranslational modification] 693982011161 intermolecular recognition site; other site 693982011162 dimerization interface [polypeptide binding]; other site 693982011163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982011164 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693982011165 putative active site [active] 693982011166 heme pocket [chemical binding]; other site 693982011167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982011168 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693982011169 putative active site [active] 693982011170 heme pocket [chemical binding]; other site 693982011171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982011172 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693982011173 putative active site [active] 693982011174 heme pocket [chemical binding]; other site 693982011175 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982011176 putative active site [active] 693982011177 heme pocket [chemical binding]; other site 693982011178 PAS domain S-box; Region: sensory_box; TIGR00229 693982011179 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982011180 putative active site [active] 693982011181 heme pocket [chemical binding]; other site 693982011182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 693982011183 HWE histidine kinase; Region: HWE_HK; pfam07536 693982011184 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693982011185 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 693982011186 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982011187 Walker A/P-loop; other site 693982011188 ATP binding site [chemical binding]; other site 693982011189 Q-loop/lid; other site 693982011190 ABC transporter signature motif; other site 693982011191 Walker B; other site 693982011192 D-loop; other site 693982011193 H-loop/switch region; other site 693982011194 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982011195 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 693982011196 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982011197 Walker A/P-loop; other site 693982011198 ATP binding site [chemical binding]; other site 693982011199 Q-loop/lid; other site 693982011200 ABC transporter signature motif; other site 693982011201 Walker B; other site 693982011202 D-loop; other site 693982011203 H-loop/switch region; other site 693982011204 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982011205 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982011206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982011207 dimer interface [polypeptide binding]; other site 693982011208 conserved gate region; other site 693982011209 putative PBP binding loops; other site 693982011210 ABC-ATPase subunit interface; other site 693982011211 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982011212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982011213 dimer interface [polypeptide binding]; other site 693982011214 conserved gate region; other site 693982011215 putative PBP binding loops; other site 693982011216 ABC-ATPase subunit interface; other site 693982011217 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 693982011218 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982011219 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 693982011220 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 693982011221 active site 693982011222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982011223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982011224 LysR substrate binding domain; Region: LysR_substrate; pfam03466 693982011225 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 693982011226 homodimer interface [polypeptide binding]; other site 693982011227 homotetramer interface [polypeptide binding]; other site 693982011228 active site pocket [active] 693982011229 cleavage site 693982011230 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 693982011231 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 693982011232 homodimer interface [polypeptide binding]; other site 693982011233 substrate-cofactor binding pocket; other site 693982011234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982011235 catalytic residue [active] 693982011236 BA14K-like protein; Region: BA14K; pfam07886 693982011237 BA14K-like protein; Region: BA14K; pfam07886 693982011238 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 693982011239 homotrimer interaction site [polypeptide binding]; other site 693982011240 putative active site [active] 693982011241 EthD domain; Region: EthD; cl17553 693982011242 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693982011243 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 693982011244 putative ligand binding site [chemical binding]; other site 693982011245 NAD binding site [chemical binding]; other site 693982011246 catalytic site [active] 693982011247 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693982011248 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693982011249 Walker A/P-loop; other site 693982011250 ATP binding site [chemical binding]; other site 693982011251 Q-loop/lid; other site 693982011252 ABC transporter signature motif; other site 693982011253 Walker B; other site 693982011254 D-loop; other site 693982011255 H-loop/switch region; other site 693982011256 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693982011257 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982011258 substrate binding pocket [chemical binding]; other site 693982011259 membrane-bound complex binding site; other site 693982011260 hinge residues; other site 693982011261 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693982011262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982011263 dimer interface [polypeptide binding]; other site 693982011264 conserved gate region; other site 693982011265 putative PBP binding loops; other site 693982011266 ABC-ATPase subunit interface; other site 693982011267 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693982011268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982011269 dimer interface [polypeptide binding]; other site 693982011270 conserved gate region; other site 693982011271 putative PBP binding loops; other site 693982011272 ABC-ATPase subunit interface; other site 693982011273 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982011274 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982011275 DNA binding site [nucleotide binding] 693982011276 domain linker motif; other site 693982011277 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 693982011278 putative dimerization interface [polypeptide binding]; other site 693982011279 putative ligand binding site [chemical binding]; other site 693982011280 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 693982011281 active site 693982011282 catalytic residues [active] 693982011283 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 693982011284 classical (c) SDRs; Region: SDR_c; cd05233 693982011285 NAD(P) binding site [chemical binding]; other site 693982011286 active site 693982011287 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 693982011288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982011289 Walker A/P-loop; other site 693982011290 ATP binding site [chemical binding]; other site 693982011291 Q-loop/lid; other site 693982011292 ABC transporter signature motif; other site 693982011293 Walker B; other site 693982011294 D-loop; other site 693982011295 H-loop/switch region; other site 693982011296 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982011297 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982011298 TM-ABC transporter signature motif; other site 693982011299 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982011300 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 693982011301 putative ligand binding site [chemical binding]; other site 693982011302 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982011303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982011304 DNA-binding site [nucleotide binding]; DNA binding site 693982011305 FCD domain; Region: FCD; pfam07729 693982011306 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 693982011307 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 693982011308 active site pocket [active] 693982011309 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982011310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982011311 DNA-binding site [nucleotide binding]; DNA binding site 693982011312 FCD domain; Region: FCD; pfam07729 693982011313 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982011314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982011315 DNA-binding site [nucleotide binding]; DNA binding site 693982011316 FCD domain; Region: FCD; pfam07729 693982011317 aldose dehydrogenase; Validated; Region: PRK06398 693982011318 classical (c) SDRs; Region: SDR_c; cd05233 693982011319 NAD(P) binding site [chemical binding]; other site 693982011320 active site 693982011321 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 693982011322 dimerization interface [polypeptide binding]; other site 693982011323 putative active cleft [active] 693982011324 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 693982011325 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 693982011326 metal binding site [ion binding]; metal-binding site 693982011327 substrate binding pocket [chemical binding]; other site 693982011328 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 693982011329 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 693982011330 active site 693982011331 zinc binding site [ion binding]; other site 693982011332 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 693982011333 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 693982011334 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 693982011335 putative NAD(P) binding site [chemical binding]; other site 693982011336 transcriptional regulator; Provisional; Region: PRK10632 693982011337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982011338 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 693982011339 putative effector binding pocket; other site 693982011340 putative dimerization interface [polypeptide binding]; other site 693982011341 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 693982011342 active site 693982011343 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 693982011344 selenophosphate synthetase; Provisional; Region: PRK00943 693982011345 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 693982011346 dimerization interface [polypeptide binding]; other site 693982011347 putative ATP binding site [chemical binding]; other site 693982011348 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 693982011349 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 693982011350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 693982011351 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982011352 Homeodomain-like domain; Region: HTH_32; pfam13565 693982011353 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693982011354 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693982011355 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 693982011356 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 693982011357 G1 box; other site 693982011358 putative GEF interaction site [polypeptide binding]; other site 693982011359 GTP/Mg2+ binding site [chemical binding]; other site 693982011360 Switch I region; other site 693982011361 G2 box; other site 693982011362 G3 box; other site 693982011363 Switch II region; other site 693982011364 G4 box; other site 693982011365 G5 box; other site 693982011366 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 693982011367 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 693982011368 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 693982011369 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 693982011370 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693982011371 Sel1-like repeats; Region: SEL1; smart00671 693982011372 Sel1-like repeats; Region: SEL1; smart00671 693982011373 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 693982011374 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 693982011375 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 693982011376 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693982011377 catalytic residue [active] 693982011378 Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058 693982011379 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 693982011380 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 693982011381 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 693982011382 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 693982011383 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693982011384 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 693982011385 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 693982011386 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 693982011387 [4Fe-4S] binding site [ion binding]; other site 693982011388 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693982011389 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 693982011390 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 693982011391 molybdopterin cofactor binding site; other site 693982011392 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 693982011393 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693982011394 P-loop; other site 693982011395 Magnesium ion binding site [ion binding]; other site 693982011396 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693982011397 Magnesium ion binding site [ion binding]; other site 693982011398 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 693982011399 ParB-like nuclease domain; Region: ParB; smart00470 693982011400 replication initiation protein RepC; Provisional; Region: PRK13824 693982011401 Replication protein C N-terminal domain; Region: RP-C; pfam03428 693982011402 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 693982011403 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 693982011404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982011405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982011406 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 693982011407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982011408 Walker A/P-loop; other site 693982011409 ATP binding site [chemical binding]; other site 693982011410 Q-loop/lid; other site 693982011411 ABC transporter signature motif; other site 693982011412 Walker B; other site 693982011413 D-loop; other site 693982011414 H-loop/switch region; other site 693982011415 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693982011416 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 693982011417 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 693982011418 NADP binding site [chemical binding]; other site 693982011419 dimer interface [polypeptide binding]; other site 693982011420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982011421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982011422 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 693982011423 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693982011424 NAD binding site [chemical binding]; other site 693982011425 catalytic residues [active] 693982011426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982011427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982011428 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 693982011429 putative effector binding pocket; other site 693982011430 putative dimerization interface [polypeptide binding]; other site 693982011431 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 693982011432 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 693982011433 dimer interface [polypeptide binding]; other site 693982011434 active site 693982011435 heme binding site [chemical binding]; other site 693982011436 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 693982011437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982011438 putative substrate translocation pore; other site 693982011439 Transcriptional activator [Transcription]; Region: ChrR; COG3806 693982011440 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 693982011441 cytosine deaminase; Validated; Region: PRK07572 693982011442 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 693982011443 active site 693982011444 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982011445 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693982011446 TM-ABC transporter signature motif; other site 693982011447 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982011448 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693982011449 TM-ABC transporter signature motif; other site 693982011450 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 693982011451 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982011452 Walker A/P-loop; other site 693982011453 ATP binding site [chemical binding]; other site 693982011454 Q-loop/lid; other site 693982011455 ABC transporter signature motif; other site 693982011456 Walker B; other site 693982011457 D-loop; other site 693982011458 H-loop/switch region; other site 693982011459 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982011460 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 693982011461 Amidase; Region: Amidase; cl11426 693982011462 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 693982011463 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 693982011464 putative ligand binding site [chemical binding]; other site 693982011465 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982011466 cyclase homology domain; Region: CHD; cd07302 693982011467 nucleotidyl binding site; other site 693982011468 metal binding site [ion binding]; metal-binding site 693982011469 dimer interface [polypeptide binding]; other site 693982011470 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 693982011471 active site 693982011472 DNA polymerase IV; Validated; Region: PRK02406 693982011473 DNA binding site [nucleotide binding] 693982011474 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693982011475 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693982011476 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982011477 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 693982011478 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 693982011479 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 693982011480 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982011481 catalytic loop [active] 693982011482 iron binding site [ion binding]; other site 693982011483 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693982011484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982011485 S-adenosylmethionine binding site [chemical binding]; other site 693982011486 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 693982011487 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 693982011488 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 693982011489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982011490 NAD(P) binding site [chemical binding]; other site 693982011491 active site 693982011492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982011493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982011494 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 693982011495 putative effector binding pocket; other site 693982011496 putative dimerization interface [polypeptide binding]; other site 693982011497 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 693982011498 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 693982011499 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693982011500 Soluble P-type ATPase [General function prediction only]; Region: COG4087 693982011501 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 693982011502 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 693982011503 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 693982011504 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 693982011505 Ligand Binding Site [chemical binding]; other site 693982011506 GAF domain; Region: GAF_3; pfam13492 693982011507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982011508 dimer interface [polypeptide binding]; other site 693982011509 phosphorylation site [posttranslational modification] 693982011510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982011511 ATP binding site [chemical binding]; other site 693982011512 Mg2+ binding site [ion binding]; other site 693982011513 G-X-G motif; other site 693982011514 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982011515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982011516 active site 693982011517 phosphorylation site [posttranslational modification] 693982011518 intermolecular recognition site; other site 693982011519 dimerization interface [polypeptide binding]; other site 693982011520 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982011521 DNA binding site [nucleotide binding] 693982011522 Ion channel; Region: Ion_trans_2; pfam07885 693982011523 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 693982011524 Part of AAA domain; Region: AAA_19; pfam13245 693982011525 Family description; Region: UvrD_C_2; pfam13538 693982011526 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 693982011527 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 693982011528 putative C-terminal domain interface [polypeptide binding]; other site 693982011529 putative GSH binding site (G-site) [chemical binding]; other site 693982011530 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982011531 putative dimer interface [polypeptide binding]; other site 693982011532 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 693982011533 dimer interface [polypeptide binding]; other site 693982011534 N-terminal domain interface [polypeptide binding]; other site 693982011535 putative substrate binding pocket (H-site) [chemical binding]; other site 693982011536 aminoglycoside resistance protein; Provisional; Region: PRK13746 693982011537 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 693982011538 active site 693982011539 NTP binding site [chemical binding]; other site 693982011540 metal binding triad [ion binding]; metal-binding site 693982011541 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 693982011542 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982011543 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982011544 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982011545 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982011546 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982011547 active site 693982011548 catalytic tetrad [active] 693982011549 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693982011550 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982011551 Walker A/P-loop; other site 693982011552 ATP binding site [chemical binding]; other site 693982011553 Q-loop/lid; other site 693982011554 ABC transporter signature motif; other site 693982011555 Walker B; other site 693982011556 D-loop; other site 693982011557 H-loop/switch region; other site 693982011558 TOBE domain; Region: TOBE_2; pfam08402 693982011559 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982011560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982011561 dimer interface [polypeptide binding]; other site 693982011562 conserved gate region; other site 693982011563 putative PBP binding loops; other site 693982011564 ABC-ATPase subunit interface; other site 693982011565 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 693982011566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982011567 dimer interface [polypeptide binding]; other site 693982011568 conserved gate region; other site 693982011569 putative PBP binding loops; other site 693982011570 ABC-ATPase subunit interface; other site 693982011571 non-specific DNA interactions [nucleotide binding]; other site 693982011572 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 693982011573 DNA binding site [nucleotide binding] 693982011574 sequence specific DNA binding site [nucleotide binding]; other site 693982011575 putative cAMP binding site [chemical binding]; other site 693982011576 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693982011577 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693982011578 nucleotide binding site [chemical binding]; other site 693982011579 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693982011580 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693982011581 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982011582 metal binding site [ion binding]; metal-binding site 693982011583 active site 693982011584 I-site; other site 693982011585 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 693982011586 Bacterial SH3 domain; Region: SH3_3; pfam08239 693982011587 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 693982011588 Transglycosylase; Region: Transgly; pfam00912 693982011589 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693982011590 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693982011591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982011592 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982011593 dimerization interface [polypeptide binding]; other site 693982011594 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693982011595 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 693982011596 active site 693982011597 FMN binding site [chemical binding]; other site 693982011598 substrate binding site [chemical binding]; other site 693982011599 putative catalytic residue [active] 693982011600 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693982011601 homotrimer interaction site [polypeptide binding]; other site 693982011602 putative active site [active] 693982011603 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693982011604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982011605 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693982011606 dimerization interface [polypeptide binding]; other site 693982011607 substrate binding pocket [chemical binding]; other site 693982011608 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 693982011609 putative dimer interface [polypeptide binding]; other site 693982011610 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982011611 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693982011612 active site 693982011613 DNA binding site [nucleotide binding] 693982011614 Int/Topo IB signature motif; other site 693982011615 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 693982011616 Predicted transcriptional regulator [Transcription]; Region: COG3905 693982011617 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 693982011618 putative active site [active] 693982011619 homotetrameric interface [polypeptide binding]; other site 693982011620 metal binding site [ion binding]; metal-binding site 693982011621 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 693982011622 Protein of unknown function (DUF904); Region: DUF904; pfam06005 693982011623 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693982011624 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 693982011625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982011626 Walker A/P-loop; other site 693982011627 ATP binding site [chemical binding]; other site 693982011628 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 693982011629 putative active site [active] 693982011630 putative metal-binding site [ion binding]; other site 693982011631 Part of AAA domain; Region: AAA_19; pfam13245 693982011632 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 693982011633 transposase; Validated; Region: PRK08181 693982011634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982011635 Walker A motif; other site 693982011636 ATP binding site [chemical binding]; other site 693982011637 Walker B motif; other site 693982011638 rod shape-determining protein MreB; Provisional; Region: PRK13930 693982011639 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 693982011640 nucleotide binding site [chemical binding]; other site 693982011641 putative NEF/HSP70 interaction site [polypeptide binding]; other site 693982011642 SBD interface [polypeptide binding]; other site 693982011643 NADH dehydrogenase subunit G; Validated; Region: PRK08493 693982011644 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693982011645 DNA-binding site [nucleotide binding]; DNA binding site 693982011646 RNA-binding motif; other site 693982011647 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 693982011648 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 693982011649 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 693982011650 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 693982011651 formate dehydrogenase; Provisional; Region: PRK07574 693982011652 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 693982011653 dimerization interface [polypeptide binding]; other site 693982011654 ligand binding site [chemical binding]; other site 693982011655 NAD binding site [chemical binding]; other site 693982011656 catalytic site [active] 693982011657 Cupin domain; Region: Cupin_2; cl17218 693982011658 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 693982011659 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 693982011660 active site 693982011661 zinc binding site [ion binding]; other site 693982011662 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982011663 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982011664 non-specific DNA binding site [nucleotide binding]; other site 693982011665 salt bridge; other site 693982011666 sequence-specific DNA binding site [nucleotide binding]; other site 693982011667 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982011668 Transposase domain (DUF772); Region: DUF772; pfam05598 693982011669 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982011670 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 693982011671 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 693982011672 ring oligomerisation interface [polypeptide binding]; other site 693982011673 ATP/Mg binding site [chemical binding]; other site 693982011674 stacking interactions; other site 693982011675 hinge regions; other site 693982011676 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 693982011677 oligomerisation interface [polypeptide binding]; other site 693982011678 mobile loop; other site 693982011679 roof hairpin; other site 693982011680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 693982011681 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693982011682 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693982011683 acyl carrier protein; Provisional; Region: acpP; PRK00982 693982011684 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693982011685 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982011686 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693982011687 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 693982011688 Cytochrome P450; Region: p450; cl12078 693982011689 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 693982011690 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 693982011691 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 693982011692 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 693982011693 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 693982011694 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 693982011695 oligomer interface [polypeptide binding]; other site 693982011696 metal binding site [ion binding]; metal-binding site 693982011697 metal binding site [ion binding]; metal-binding site 693982011698 putative Cl binding site [ion binding]; other site 693982011699 basic sphincter; other site 693982011700 hydrophobic gate; other site 693982011701 periplasmic entrance; other site 693982011702 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982011703 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982011704 DNA binding residues [nucleotide binding] 693982011705 dimerization interface [polypeptide binding]; other site 693982011706 Uncharacterized conserved protein [Function unknown]; Region: COG1432 693982011707 LabA_like proteins; Region: LabA; cd10911 693982011708 putative metal binding site [ion binding]; other site 693982011709 transposase; Validated; Region: PRK08181 693982011710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982011711 Walker A motif; other site 693982011712 ATP binding site [chemical binding]; other site 693982011713 Walker B motif; other site 693982011714 Integrase core domain; Region: rve; pfam00665 693982011715 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693982011716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982011717 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693982011718 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693982011719 Transposase; Region: HTH_Tnp_1; pfam01527 693982011720 PAS fold; Region: PAS_7; pfam12860 693982011721 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693982011722 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982011723 metal binding site [ion binding]; metal-binding site 693982011724 active site 693982011725 I-site; other site 693982011726 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693982011727 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 693982011728 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 693982011729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982011730 catalytic residue [active] 693982011731 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 693982011732 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982011733 putative DNA binding site [nucleotide binding]; other site 693982011734 putative Zn2+ binding site [ion binding]; other site 693982011735 AsnC family; Region: AsnC_trans_reg; pfam01037 693982011736 Thiamine monophosphate synthase/TENI; Region: TMP-TENI; cl17228 693982011737 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693982011738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693982011739 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693982011740 putative transposase OrfB; Reviewed; Region: PHA02517 693982011741 HTH-like domain; Region: HTH_21; pfam13276 693982011742 Integrase core domain; Region: rve; pfam00665 693982011743 Integrase core domain; Region: rve_3; pfam13683 693982011744 Transposase; Region: HTH_Tnp_1; pfam01527 693982011745 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 693982011746 thiS-thiF/thiG interaction site; other site 693982011747 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 693982011748 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 693982011749 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 693982011750 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693982011751 catalytic residues [active] 693982011752 Predicted chitinase [General function prediction only]; Region: COG3179 693982011753 catalytic residue [active] 693982011754 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982011755 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693982011756 DNA-binding site [nucleotide binding]; DNA binding site 693982011757 RNA-binding motif; other site 693982011758 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 693982011759 nudix motif; other site 693982011760 Predicted transcriptional regulator [Transcription]; Region: COG4957 693982011761 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982011762 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693982011763 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693982011764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982011765 S-adenosylmethionine binding site [chemical binding]; other site 693982011766 transposase/IS protein; Provisional; Region: PRK09183 693982011767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982011768 Walker A motif; other site 693982011769 ATP binding site [chemical binding]; other site 693982011770 Walker B motif; other site 693982011771 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 693982011772 TPP-binding site [chemical binding]; other site 693982011773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 693982011774 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982011775 Homeodomain-like domain; Region: HTH_32; pfam13565 693982011776 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693982011777 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693982011778 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 693982011779 rod shape-determining protein MreC; Provisional; Region: PRK13922 693982011780 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 693982011781 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982011782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982011783 non-specific DNA binding site [nucleotide binding]; other site 693982011784 salt bridge; other site 693982011785 sequence-specific DNA binding site [nucleotide binding]; other site 693982011786 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 693982011787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982011788 sequence-specific DNA binding site [nucleotide binding]; other site 693982011789 salt bridge; other site 693982011790 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693982011791 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693982011792 P-loop; other site 693982011793 Magnesium ion binding site [ion binding]; other site 693982011794 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 693982011795 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 693982011796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 693982011797 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982011798 Homeodomain-like domain; Region: HTH_32; pfam13565 693982011799 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693982011800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693982011801 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693982011802 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982011803 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693982011804 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693982011805 short chain dehydrogenase; Provisional; Region: PRK07478 693982011806 classical (c) SDRs; Region: SDR_c; cd05233 693982011807 NAD(P) binding site [chemical binding]; other site 693982011808 active site 693982011809 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 693982011810 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693982011811 Walker A motif; other site 693982011812 ATP binding site [chemical binding]; other site 693982011813 Walker B motif; other site 693982011814 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 693982011815 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 693982011816 Walker A motif; other site 693982011817 hexamer interface [polypeptide binding]; other site 693982011818 ATP binding site [chemical binding]; other site 693982011819 Walker B motif; other site 693982011820 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 693982011821 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 693982011822 VirB7 interaction site; other site 693982011823 VirB8 protein; Region: VirB8; pfam04335 693982011824 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 693982011825 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 693982011826 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693982011827 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693982011828 catalytic residue [active] 693982011829 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 693982011830 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 693982011831 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 693982011832 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 693982011833 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 693982011834 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693982011835 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693982011836 catalytic residue [active] 693982011837 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 693982011838 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 693982011839 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 693982011840 Staphylococcal nuclease homologues; Region: SNc; smart00318 693982011841 Catalytic site; other site 693982011842 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 693982011843 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693982011844 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 693982011845 B3/4 domain; Region: B3_4; pfam03483 693982011846 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 693982011847 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693982011848 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982011849 DNA-binding site [nucleotide binding]; DNA binding site 693982011850 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982011851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982011852 homodimer interface [polypeptide binding]; other site 693982011853 catalytic residue [active] 693982011854 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693982011855 DNA-binding site [nucleotide binding]; DNA binding site 693982011856 RNA-binding motif; other site 693982011857 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693982011858 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 693982011859 catalytic site [active] 693982011860 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693982011861 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982011862 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693982011863 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693982011864 pyruvate phosphate dikinase; Provisional; Region: PRK09279 693982011865 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 693982011866 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693982011867 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693982011868 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693982011869 EamA-like transporter family; Region: EamA; pfam00892 693982011870 EamA-like transporter family; Region: EamA; pfam00892 693982011871 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 693982011872 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 693982011873 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693982011874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982011875 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 693982011876 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693982011877 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693982011878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982011879 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693982011880 Transposase; Region: HTH_Tnp_1; pfam01527 693982011881 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693982011882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982011883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982011884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982011885 dimerization interface [polypeptide binding]; other site 693982011886 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 693982011887 Dehydroquinase class II; Region: DHquinase_II; pfam01220 693982011888 trimer interface [polypeptide binding]; other site 693982011889 active site 693982011890 dimer interface [polypeptide binding]; other site 693982011891 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 693982011892 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693982011893 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693982011894 catalytic residue [active] 693982011895 DctM-like transporters; Region: DctM; pfam06808 693982011896 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693982011897 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 693982011898 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 693982011899 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982011900 Walker A/P-loop; other site 693982011901 ATP binding site [chemical binding]; other site 693982011902 Q-loop/lid; other site 693982011903 ABC transporter signature motif; other site 693982011904 Walker B; other site 693982011905 D-loop; other site 693982011906 H-loop/switch region; other site 693982011907 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 693982011908 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 693982011909 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 693982011910 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982011911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982011912 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982011913 dimerization interface [polypeptide binding]; other site 693982011914 aspartate aminotransferase; Provisional; Region: PRK05764 693982011915 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982011916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982011917 homodimer interface [polypeptide binding]; other site 693982011918 catalytic residue [active] 693982011919 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 693982011920 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693982011921 tetramer interface [polypeptide binding]; other site 693982011922 active site 693982011923 Mg2+/Mn2+ binding site [ion binding]; other site 693982011924 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 693982011925 homotrimer interaction site [polypeptide binding]; other site 693982011926 putative active site [active] 693982011927 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982011928 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693982011929 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 693982011930 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 693982011931 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693982011932 FAD binding domain; Region: FAD_binding_4; pfam01565 693982011933 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 693982011934 Homeodomain-like domain; Region: HTH_32; pfam13565 693982011935 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693982011936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693982011937 methionine sulfoxide reductase A; Provisional; Region: PRK14054 693982011938 methionine sulfoxide reductase B; Provisional; Region: PRK00222 693982011939 SelR domain; Region: SelR; pfam01641 693982011940 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982011941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982011942 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693982011943 dimerization interface [polypeptide binding]; other site 693982011944 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982011945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982011946 NAD(P) binding site [chemical binding]; other site 693982011947 active site 693982011948 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 693982011949 Uncharacterized conserved protein [Function unknown]; Region: COG2128 693982011950 Cupin domain; Region: Cupin_2; pfam07883 693982011951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982011952 DNA-binding site [nucleotide binding]; DNA binding site 693982011953 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693982011954 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693982011955 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693982011956 catalytic residue [active] 693982011957 TfuA-like protein; Region: TfuA; pfam07812 693982011958 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 693982011959 YcaO-like family; Region: YcaO; pfam02624 693982011960 SAM domain (Sterile alpha motif); Region: SAM_2; pfam07647 693982011961 SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487 693982011962 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982011963 cyclase homology domain; Region: CHD; cd07302 693982011964 nucleotidyl binding site; other site 693982011965 metal binding site [ion binding]; metal-binding site 693982011966 dimer interface [polypeptide binding]; other site 693982011967 Predicted ATPase [General function prediction only]; Region: COG3899 693982011968 AAA ATPase domain; Region: AAA_16; pfam13191 693982011969 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 693982011970 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 693982011971 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982011972 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 693982011973 Uncharacterized conserved protein [Function unknown]; Region: COG2135 693982011974 Uncharacterized conserved protein [Function unknown]; Region: COG4544 693982011975 DNA Polymerase Y-family; Region: PolY_like; cd03468 693982011976 active site 693982011977 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 693982011978 DNA binding site [nucleotide binding] 693982011979 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 693982011980 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 693982011981 putative active site [active] 693982011982 putative PHP Thumb interface [polypeptide binding]; other site 693982011983 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 693982011984 generic binding surface II; other site 693982011985 generic binding surface I; other site 693982011986 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 693982011987 Antirestriction protein; Region: Antirestrict; pfam03230 693982011988 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 693982011989 Helicase_C-like; Region: Helicase_C_4; pfam13871 693982011990 Toprim domain; Region: Toprim_3; pfam13362 693982011991 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 693982011992 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 693982011993 Uncharacterized conserved protein [Function unknown]; Region: COG5489 693982011994 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 693982011995 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 693982011996 Walker A motif; other site 693982011997 ATP binding site [chemical binding]; other site 693982011998 Walker B motif; other site 693982011999 Conjugal transfer protein TraD; Region: TraD; pfam06412 693982012000 TraC-like protein; Region: TraC; pfam07820 693982012001 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693982012002 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693982012003 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693982012004 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982012005 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 693982012006 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 693982012007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982012008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982012009 dimer interface [polypeptide binding]; other site 693982012010 phosphorylation site [posttranslational modification] 693982012011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982012012 ATP binding site [chemical binding]; other site 693982012013 Mg2+ binding site [ion binding]; other site 693982012014 G-X-G motif; other site 693982012015 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 693982012016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982012017 active site 693982012018 phosphorylation site [posttranslational modification] 693982012019 intermolecular recognition site; other site 693982012020 dimerization interface [polypeptide binding]; other site 693982012021 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982012022 DNA binding residues [nucleotide binding] 693982012023 dimerization interface [polypeptide binding]; other site 693982012024 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 693982012025 Sulfatase; Region: Sulfatase; pfam00884 693982012026 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 693982012027 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 693982012028 metal binding site [ion binding]; metal-binding site 693982012029 dimer interface [polypeptide binding]; other site 693982012030 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 693982012031 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 693982012032 putative active site [active] 693982012033 putative metal binding site [ion binding]; other site 693982012034 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; pfam09587 693982012035 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 693982012036 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982012037 Walker A/P-loop; other site 693982012038 ATP binding site [chemical binding]; other site 693982012039 Q-loop/lid; other site 693982012040 ABC transporter signature motif; other site 693982012041 Walker B; other site 693982012042 D-loop; other site 693982012043 H-loop/switch region; other site 693982012044 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982012045 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982012046 Walker A/P-loop; other site 693982012047 ATP binding site [chemical binding]; other site 693982012048 Q-loop/lid; other site 693982012049 ABC transporter signature motif; other site 693982012050 Walker B; other site 693982012051 D-loop; other site 693982012052 H-loop/switch region; other site 693982012053 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982012054 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982012055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982012056 dimer interface [polypeptide binding]; other site 693982012057 conserved gate region; other site 693982012058 putative PBP binding loops; other site 693982012059 ABC-ATPase subunit interface; other site 693982012060 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982012061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982012062 dimer interface [polypeptide binding]; other site 693982012063 conserved gate region; other site 693982012064 putative PBP binding loops; other site 693982012065 ABC-ATPase subunit interface; other site 693982012066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 693982012067 non-specific DNA binding site [nucleotide binding]; other site 693982012068 salt bridge; other site 693982012069 sequence-specific DNA binding site [nucleotide binding]; other site 693982012070 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693982012071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982012072 Coenzyme A binding pocket [chemical binding]; other site 693982012073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982012074 S-adenosylmethionine binding site [chemical binding]; other site 693982012075 Autoinducer binding domain; Region: Autoind_bind; pfam03472 693982012076 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982012077 DNA binding residues [nucleotide binding] 693982012078 dimerization interface [polypeptide binding]; other site 693982012079 Autoinducer synthetase; Region: Autoind_synth; cl17404 693982012080 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982012081 Winged helix-turn helix; Region: HTH_29; pfam13551 693982012082 Homeodomain-like domain; Region: HTH_32; pfam13565 693982012083 Integrase core domain; Region: rve; pfam00665 693982012084 transposase; Validated; Region: PRK08181 693982012085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982012086 Walker A motif; other site 693982012087 ATP binding site [chemical binding]; other site 693982012088 Walker B motif; other site 693982012089 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982012090 Winged helix-turn helix; Region: HTH_29; pfam13551 693982012091 Homeodomain-like domain; Region: HTH_32; pfam13565 693982012092 Integrase core domain; Region: rve; pfam00665 693982012093 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693982012094 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 693982012095 DNA-binding interface [nucleotide binding]; DNA binding site 693982012096 Homeodomain-like domain; Region: HTH_32; pfam13565 693982012097 Integrase core domain; Region: rve; pfam00665 693982012098 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 693982012099 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 693982012100 oligomeric interface; other site 693982012101 putative active site [active] 693982012102 homodimer interface [polypeptide binding]; other site 693982012103 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 693982012104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982012105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982012106 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982012107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982012108 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 693982012109 putative effector binding pocket; other site 693982012110 putative dimerization interface [polypeptide binding]; other site 693982012111 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982012112 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982012113 active site 693982012114 catalytic tetrad [active] 693982012115 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 693982012116 active site 1 [active] 693982012117 dimer interface [polypeptide binding]; other site 693982012118 hexamer interface [polypeptide binding]; other site 693982012119 active site 2 [active] 693982012120 short chain dehydrogenase; Provisional; Region: PRK12937 693982012121 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 693982012122 NADP binding site [chemical binding]; other site 693982012123 homodimer interface [polypeptide binding]; other site 693982012124 active site 693982012125 substrate binding site [chemical binding]; other site 693982012126 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982012127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982012128 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 693982012129 putative effector binding pocket; other site 693982012130 putative dimerization interface [polypeptide binding]; other site 693982012131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693982012132 Uncharacterized conserved protein [Function unknown]; Region: COG1633 693982012133 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 693982012134 diiron binding motif [ion binding]; other site 693982012135 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 693982012136 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 693982012137 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 693982012138 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 693982012139 FAD binding pocket [chemical binding]; other site 693982012140 FAD binding motif [chemical binding]; other site 693982012141 phosphate binding motif [ion binding]; other site 693982012142 beta-alpha-beta structure motif; other site 693982012143 NAD binding pocket [chemical binding]; other site 693982012144 Heme binding pocket [chemical binding]; other site 693982012145 Regulator of cell morphogenesis and NO signaling [Cell division and chromosome partitioning]; Region: COG2846 693982012146 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 693982012147 Hemerythrin-like domain; Region: Hr-like; cd12108 693982012148 Fe binding site [ion binding]; other site 693982012149 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 693982012150 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 693982012151 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 693982012152 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693982012153 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693982012154 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 693982012155 cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847 693982012156 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 693982012157 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693982012158 metal-binding site [ion binding] 693982012159 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693982012160 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 693982012161 FixH; Region: FixH; pfam05751 693982012162 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 693982012163 4Fe-4S binding domain; Region: Fer4_5; pfam12801 693982012164 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 693982012165 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 693982012166 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693982012167 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693982012168 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 693982012169 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 693982012170 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 693982012171 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 693982012172 Low-spin heme binding site [chemical binding]; other site 693982012173 Putative water exit pathway; other site 693982012174 Binuclear center (active site) [active] 693982012175 Putative proton exit pathway; other site 693982012176 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 693982012177 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 693982012178 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693982012179 ligand binding site [chemical binding]; other site 693982012180 flexible hinge region; other site 693982012181 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693982012182 putative switch regulator; other site 693982012183 non-specific DNA interactions [nucleotide binding]; other site 693982012184 DNA binding site [nucleotide binding] 693982012185 sequence specific DNA binding site [nucleotide binding]; other site 693982012186 putative cAMP binding site [chemical binding]; other site 693982012187 response regulator FixJ; Provisional; Region: fixJ; PRK09390 693982012188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982012189 active site 693982012190 phosphorylation site [posttranslational modification] 693982012191 intermolecular recognition site; other site 693982012192 dimerization interface [polypeptide binding]; other site 693982012193 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982012194 DNA binding residues [nucleotide binding] 693982012195 dimerization interface [polypeptide binding]; other site 693982012196 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 693982012197 PAS domain S-box; Region: sensory_box; TIGR00229 693982012198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982012199 putative active site [active] 693982012200 heme pocket [chemical binding]; other site 693982012201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982012202 dimer interface [polypeptide binding]; other site 693982012203 phosphorylation site [posttranslational modification] 693982012204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982012205 ATP binding site [chemical binding]; other site 693982012206 Mg2+ binding site [ion binding]; other site 693982012207 G-X-G motif; other site 693982012208 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 693982012209 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 693982012210 Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043 693982012211 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 693982012212 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 693982012213 [4Fe-4S] binding site [ion binding]; other site 693982012214 molybdopterin cofactor binding site; other site 693982012215 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 693982012216 molybdopterin cofactor binding site; other site 693982012217 Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062 693982012218 ferredoxin-type protein; Provisional; Region: PRK10194 693982012219 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 693982012220 4Fe-4S binding domain; Region: Fer4; pfam00037 693982012221 Periplasmic nitrate reductase system, NapE component [Energy production and conversion]; Region: NapE; COG4459 693982012222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982012223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982012224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982012225 putative substrate translocation pore; other site 693982012226 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693982012227 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 693982012228 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 693982012229 Walker A motif; other site 693982012230 hexamer interface [polypeptide binding]; other site 693982012231 ATP binding site [chemical binding]; other site 693982012232 Walker B motif; other site 693982012233 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 693982012234 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 693982012235 VirB7 interaction site; other site 693982012236 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 693982012237 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 693982012238 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 693982012239 Type IV secretion system proteins; Region: T4SS; pfam07996 693982012240 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 693982012241 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 693982012242 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 693982012243 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 693982012244 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 693982012245 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 693982012246 RibD C-terminal domain; Region: RibD_C; cl17279 693982012247 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693982012248 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693982012249 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 693982012250 TAP-like protein; Region: Abhydrolase_4; pfam08386 693982012251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982012252 metabolite-proton symporter; Region: 2A0106; TIGR00883 693982012253 putative substrate translocation pore; other site 693982012254 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 693982012255 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 693982012256 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 693982012257 active site 693982012258 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 693982012259 Cupin domain; Region: Cupin_2; pfam07883 693982012260 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 693982012261 Uncharacterized conserved protein [Function unknown]; Region: COG5441 693982012262 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 693982012263 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982012264 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982012265 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 693982012266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982012267 conserved gate region; other site 693982012268 dimer interface [polypeptide binding]; other site 693982012269 putative PBP binding loops; other site 693982012270 ABC-ATPase subunit interface; other site 693982012271 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982012272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982012273 dimer interface [polypeptide binding]; other site 693982012274 conserved gate region; other site 693982012275 putative PBP binding loops; other site 693982012276 ABC-ATPase subunit interface; other site 693982012277 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693982012278 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982012279 Walker A/P-loop; other site 693982012280 ATP binding site [chemical binding]; other site 693982012281 Q-loop/lid; other site 693982012282 ABC transporter signature motif; other site 693982012283 Walker B; other site 693982012284 D-loop; other site 693982012285 H-loop/switch region; other site 693982012286 TOBE domain; Region: TOBE_2; pfam08402 693982012287 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693982012288 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982012289 Walker A/P-loop; other site 693982012290 ATP binding site [chemical binding]; other site 693982012291 Q-loop/lid; other site 693982012292 ABC transporter signature motif; other site 693982012293 Walker B; other site 693982012294 D-loop; other site 693982012295 H-loop/switch region; other site 693982012296 TOBE domain; Region: TOBE_2; pfam08402 693982012297 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693982012298 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 693982012299 ligand binding site [chemical binding]; other site 693982012300 NAD binding site [chemical binding]; other site 693982012301 dimerization interface [polypeptide binding]; other site 693982012302 catalytic site [active] 693982012303 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982012304 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982012305 DNA-binding site [nucleotide binding]; DNA binding site 693982012306 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693982012307 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 693982012308 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 693982012309 active site pocket [active] 693982012310 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693982012311 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 693982012312 DNA interaction; other site 693982012313 Metal-binding active site; metal-binding site 693982012314 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693982012315 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 693982012316 Metal-binding active site; metal-binding site 693982012317 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 693982012318 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 693982012319 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982012320 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693982012321 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693982012322 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 693982012323 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982012324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982012325 dimer interface [polypeptide binding]; other site 693982012326 conserved gate region; other site 693982012327 putative PBP binding loops; other site 693982012328 ABC-ATPase subunit interface; other site 693982012329 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 693982012330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982012331 putative PBP binding loops; other site 693982012332 ABC-ATPase subunit interface; other site 693982012333 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982012334 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693982012335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982012336 H-loop/switch region; other site 693982012337 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982012338 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 693982012339 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982012340 Walker A/P-loop; other site 693982012341 ATP binding site [chemical binding]; other site 693982012342 Q-loop/lid; other site 693982012343 ABC transporter signature motif; other site 693982012344 Walker B; other site 693982012345 D-loop; other site 693982012346 H-loop/switch region; other site 693982012347 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 693982012348 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 693982012349 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982012350 Walker A/P-loop; other site 693982012351 ATP binding site [chemical binding]; other site 693982012352 Q-loop/lid; other site 693982012353 ABC transporter signature motif; other site 693982012354 Walker B; other site 693982012355 D-loop; other site 693982012356 H-loop/switch region; other site 693982012357 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982012358 dipeptide transporter; Provisional; Region: PRK10913 693982012359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982012360 dimer interface [polypeptide binding]; other site 693982012361 conserved gate region; other site 693982012362 putative PBP binding loops; other site 693982012363 ABC-ATPase subunit interface; other site 693982012364 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982012365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982012366 dimer interface [polypeptide binding]; other site 693982012367 conserved gate region; other site 693982012368 putative PBP binding loops; other site 693982012369 ABC-ATPase subunit interface; other site 693982012370 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 693982012371 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 693982012372 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 693982012373 Amidase; Region: Amidase; cl11426 693982012374 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982012375 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 693982012376 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 693982012377 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 693982012378 catalytic loop [active] 693982012379 iron binding site [ion binding]; other site 693982012380 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982012381 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693982012382 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982012383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982012384 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693982012385 dimerization interface [polypeptide binding]; other site 693982012386 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 693982012387 Ligand binding site [chemical binding]; other site 693982012388 Electron transfer flavoprotein domain; Region: ETF; pfam01012 693982012389 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 693982012390 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 693982012391 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 693982012392 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693982012393 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 693982012394 Metal-binding active site; metal-binding site 693982012395 Protein of unknown function (DUF993); Region: DUF993; pfam06187 693982012396 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 693982012397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982012398 NAD(P) binding site [chemical binding]; other site 693982012399 active site 693982012400 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693982012401 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693982012402 active site 693982012403 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982012404 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982012405 active site 693982012406 catalytic tetrad [active] 693982012407 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 693982012408 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 693982012409 MOFRL family; Region: MOFRL; pfam05161 693982012410 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 693982012411 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693982012412 substrate binding site [chemical binding]; other site 693982012413 oxyanion hole (OAH) forming residues; other site 693982012414 trimer interface [polypeptide binding]; other site 693982012415 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 693982012416 Coenzyme A transferase; Region: CoA_trans; smart00882 693982012417 Coenzyme A transferase; Region: CoA_trans; cl17247 693982012418 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982012419 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982012420 active site 693982012421 catalytic tetrad [active] 693982012422 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 693982012423 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 693982012424 choline dehydrogenase; Validated; Region: PRK02106 693982012425 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 693982012426 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693982012427 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 693982012428 NAD(P) binding site [chemical binding]; other site 693982012429 catalytic residues [active] 693982012430 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693982012431 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693982012432 NAD(P) binding site [chemical binding]; other site 693982012433 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982012434 TM-ABC transporter signature motif; other site 693982012435 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982012436 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982012437 Walker A/P-loop; other site 693982012438 ATP binding site [chemical binding]; other site 693982012439 Q-loop/lid; other site 693982012440 ABC transporter signature motif; other site 693982012441 Walker B; other site 693982012442 D-loop; other site 693982012443 H-loop/switch region; other site 693982012444 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982012445 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982012446 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982012447 TM-ABC transporter signature motif; other site 693982012448 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982012449 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 693982012450 ligand binding site [chemical binding]; other site 693982012451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982012452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982012453 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693982012454 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693982012455 NAD(P) binding site [chemical binding]; other site 693982012456 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982012457 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 693982012458 active site 693982012459 metal binding site [ion binding]; metal-binding site 693982012460 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 693982012461 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982012462 Walker A/P-loop; other site 693982012463 ATP binding site [chemical binding]; other site 693982012464 Q-loop/lid; other site 693982012465 ABC transporter signature motif; other site 693982012466 Walker B; other site 693982012467 D-loop; other site 693982012468 H-loop/switch region; other site 693982012469 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 693982012470 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982012471 Walker A/P-loop; other site 693982012472 ATP binding site [chemical binding]; other site 693982012473 Q-loop/lid; other site 693982012474 ABC transporter signature motif; other site 693982012475 Walker B; other site 693982012476 D-loop; other site 693982012477 H-loop/switch region; other site 693982012478 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982012479 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982012480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982012481 dimer interface [polypeptide binding]; other site 693982012482 conserved gate region; other site 693982012483 putative PBP binding loops; other site 693982012484 ABC-ATPase subunit interface; other site 693982012485 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982012486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982012487 dimer interface [polypeptide binding]; other site 693982012488 conserved gate region; other site 693982012489 putative PBP binding loops; other site 693982012490 ABC-ATPase subunit interface; other site 693982012491 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982012492 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 693982012493 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 693982012494 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 693982012495 putative active site [active] 693982012496 catalytic residue [active] 693982012497 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982012498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982012499 DNA-binding site [nucleotide binding]; DNA binding site 693982012500 FCD domain; Region: FCD; pfam07729 693982012501 Ferritin-like domain; Region: Ferritin_2; pfam13668 693982012502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982012503 putative substrate translocation pore; other site 693982012504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982012505 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 693982012506 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693982012507 dimer interface [polypeptide binding]; other site 693982012508 active site 693982012509 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 693982012510 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 693982012511 NAD binding site [chemical binding]; other site 693982012512 homodimer interface [polypeptide binding]; other site 693982012513 homotetramer interface [polypeptide binding]; other site 693982012514 active site 693982012515 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 693982012516 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693982012517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982012518 Uncharacterized conserved protein [Function unknown]; Region: COG5654 693982012519 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 693982012520 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 693982012521 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 693982012522 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 693982012523 active site pocket [active] 693982012524 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 693982012525 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 693982012526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982012527 dimer interface [polypeptide binding]; other site 693982012528 conserved gate region; other site 693982012529 putative PBP binding loops; other site 693982012530 ABC-ATPase subunit interface; other site 693982012531 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 693982012532 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 693982012533 Walker A/P-loop; other site 693982012534 ATP binding site [chemical binding]; other site 693982012535 Q-loop/lid; other site 693982012536 ABC transporter signature motif; other site 693982012537 Walker B; other site 693982012538 D-loop; other site 693982012539 H-loop/switch region; other site 693982012540 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 693982012541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982012542 dimer interface [polypeptide binding]; other site 693982012543 conserved gate region; other site 693982012544 ABC-ATPase subunit interface; other site 693982012545 Isochorismatase family; Region: Isochorismatase; pfam00857 693982012546 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 693982012547 catalytic triad [active] 693982012548 conserved cis-peptide bond; other site 693982012549 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 693982012550 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 693982012551 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 693982012552 active site 693982012553 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 693982012554 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 693982012555 conserved cys residue [active] 693982012556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982012557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982012558 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 693982012559 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693982012560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982012561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982012562 dimerization interface [polypeptide binding]; other site 693982012563 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982012564 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693982012565 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 693982012566 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 693982012567 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693982012568 Uncharacterized conserved protein [Function unknown]; Region: COG4925 693982012569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982012570 putative substrate translocation pore; other site 693982012571 Cytochrome c2 [Energy production and conversion]; Region: COG3474 693982012572 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982012573 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693982012574 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693982012575 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982012576 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982012577 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 693982012578 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982012579 catalytic loop [active] 693982012580 iron binding site [ion binding]; other site 693982012581 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693982012582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982012583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982012584 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 693982012585 putative effector binding pocket; other site 693982012586 putative dimerization interface [polypeptide binding]; other site 693982012587 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 693982012588 homodimer interface [polypeptide binding]; other site 693982012589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982012590 catalytic residue [active] 693982012591 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982012592 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 693982012593 putative C-terminal domain interface [polypeptide binding]; other site 693982012594 putative GSH binding site (G-site) [chemical binding]; other site 693982012595 putative dimer interface [polypeptide binding]; other site 693982012596 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 693982012597 putative N-terminal domain interface [polypeptide binding]; other site 693982012598 putative dimer interface [polypeptide binding]; other site 693982012599 putative substrate binding pocket (H-site) [chemical binding]; other site 693982012600 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 693982012601 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 693982012602 [2Fe-2S] cluster binding site [ion binding]; other site 693982012603 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 693982012604 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 693982012605 FMN-binding pocket [chemical binding]; other site 693982012606 flavin binding motif; other site 693982012607 phosphate binding motif [ion binding]; other site 693982012608 beta-alpha-beta structure motif; other site 693982012609 NAD binding pocket [chemical binding]; other site 693982012610 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982012611 catalytic loop [active] 693982012612 iron binding site [ion binding]; other site 693982012613 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 693982012614 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 693982012615 hydrophobic ligand binding site; other site 693982012616 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 693982012617 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 693982012618 hydrophobic ligand binding site; other site 693982012619 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982012620 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982012621 DNA-binding site [nucleotide binding]; DNA binding site 693982012622 FCD domain; Region: FCD; pfam07729 693982012623 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 693982012624 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 693982012625 putative ligand binding site [chemical binding]; other site 693982012626 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 693982012627 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982012628 Walker A/P-loop; other site 693982012629 ATP binding site [chemical binding]; other site 693982012630 Q-loop/lid; other site 693982012631 ABC transporter signature motif; other site 693982012632 Walker B; other site 693982012633 D-loop; other site 693982012634 H-loop/switch region; other site 693982012635 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982012636 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982012637 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693982012638 TM-ABC transporter signature motif; other site 693982012639 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982012640 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693982012641 TM-ABC transporter signature motif; other site 693982012642 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 693982012643 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 693982012644 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 693982012645 4Fe-4S binding domain; Region: Fer4; pfam00037 693982012646 FOG: CBS domain [General function prediction only]; Region: COG0517 693982012647 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 693982012648 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 693982012649 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982012650 catalytic loop [active] 693982012651 iron binding site [ion binding]; other site 693982012652 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 693982012653 4Fe-4S binding domain; Region: Fer4; pfam00037 693982012654 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 693982012655 [4Fe-4S] binding site [ion binding]; other site 693982012656 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 693982012657 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 693982012658 SLBB domain; Region: SLBB; pfam10531 693982012659 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 693982012660 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 693982012661 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 693982012662 putative dimer interface [polypeptide binding]; other site 693982012663 [2Fe-2S] cluster binding site [ion binding]; other site 693982012664 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 693982012665 NADH dehydrogenase subunit D; Validated; Region: PRK06075 693982012666 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 693982012667 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 693982012668 NADH dehydrogenase subunit B; Validated; Region: PRK06411 693982012669 NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838 693982012670 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 693982012671 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693982012672 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 693982012673 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693982012674 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 693982012675 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693982012676 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 693982012677 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693982012678 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713 693982012679 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 693982012680 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 693982012681 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 693982012682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982012683 S-adenosylmethionine binding site [chemical binding]; other site 693982012684 PAS fold; Region: PAS_4; pfam08448 693982012685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982012686 putative active site [active] 693982012687 heme pocket [chemical binding]; other site 693982012688 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693982012689 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982012690 putative active site [active] 693982012691 heme pocket [chemical binding]; other site 693982012692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982012693 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693982012694 putative active site [active] 693982012695 heme pocket [chemical binding]; other site 693982012696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982012697 putative active site [active] 693982012698 heme pocket [chemical binding]; other site 693982012699 PAS domain; Region: PAS; smart00091 693982012700 PAS fold; Region: PAS_4; pfam08448 693982012701 putative active site [active] 693982012702 heme pocket [chemical binding]; other site 693982012703 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693982012704 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982012705 metal binding site [ion binding]; metal-binding site 693982012706 active site 693982012707 I-site; other site 693982012708 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693982012709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982012710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982012711 active site 693982012712 phosphorylation site [posttranslational modification] 693982012713 intermolecular recognition site; other site 693982012714 dimerization interface [polypeptide binding]; other site 693982012715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982012716 DNA binding residues [nucleotide binding] 693982012717 dimerization interface [polypeptide binding]; other site 693982012718 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 693982012719 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 693982012720 TPR repeat; Region: TPR_11; pfam13414 693982012721 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 693982012722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693982012723 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693982012724 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693982012725 dimer interface [polypeptide binding]; other site 693982012726 putative CheW interface [polypeptide binding]; other site 693982012727 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693982012728 putative binding surface; other site 693982012729 active site 693982012730 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 693982012731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982012732 ATP binding site [chemical binding]; other site 693982012733 Mg2+ binding site [ion binding]; other site 693982012734 G-X-G motif; other site 693982012735 CheW-like domain; Region: CheW; pfam01584 693982012736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982012737 Response regulator receiver domain; Region: Response_reg; pfam00072 693982012738 active site 693982012739 phosphorylation site [posttranslational modification] 693982012740 intermolecular recognition site; other site 693982012741 dimerization interface [polypeptide binding]; other site 693982012742 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 693982012743 CheB methylesterase; Region: CheB_methylest; pfam01339 693982012744 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 693982012745 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693982012746 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 693982012747 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693982012748 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 693982012749 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 693982012750 ATP binding site [chemical binding]; other site 693982012751 Walker A motif; other site 693982012752 hexamer interface [polypeptide binding]; other site 693982012753 Walker B motif; other site 693982012754 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 693982012755 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 693982012756 TadE-like protein; Region: TadE; pfam07811 693982012757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 693982012758 active site 693982012759 dimerization interface [polypeptide binding]; other site 693982012760 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 693982012761 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 693982012762 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 693982012763 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 693982012764 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 693982012765 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 693982012766 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 693982012767 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 693982012768 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 693982012769 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693982012770 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982012771 cyclase homology domain; Region: CHD; cd07302 693982012772 nucleotidyl binding site; other site 693982012773 metal binding site [ion binding]; metal-binding site 693982012774 dimer interface [polypeptide binding]; other site 693982012775 Predicted integral membrane protein [Function unknown]; Region: COG5616 693982012776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982012777 TPR motif; other site 693982012778 TPR repeat; Region: TPR_11; pfam13414 693982012779 binding surface 693982012780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982012781 binding surface 693982012782 TPR motif; other site 693982012783 Tetratricopeptide repeat; Region: TPR_16; pfam13432 693982012784 Transposase; Region: HTH_Tnp_1; cl17663 693982012785 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 693982012786 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 693982012787 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 693982012788 active site 693982012789 catalytic residues [active] 693982012790 Predicted ester cyclase [General function prediction only]; Region: COG5485 693982012791 Sterile alpha motif; Region: SAM; smart00454 693982012792 SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487 693982012793 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982012794 cyclase homology domain; Region: CHD; cd07302 693982012795 nucleotidyl binding site; other site 693982012796 metal binding site [ion binding]; metal-binding site 693982012797 dimer interface [polypeptide binding]; other site 693982012798 Predicted ATPase [General function prediction only]; Region: COG3899 693982012799 AAA ATPase domain; Region: AAA_16; pfam13191 693982012800 Predicted ATPase [General function prediction only]; Region: COG3903 693982012801 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982012802 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 693982012803 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 693982012804 [2Fe-2S] cluster binding site [ion binding]; other site 693982012805 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 693982012806 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693982012807 Transposase domain (DUF772); Region: DUF772; pfam05598 693982012808 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693982012809 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 693982012810 putative cation:proton antiport protein; Provisional; Region: PRK10669 693982012811 TrkA-N domain; Region: TrkA_N; pfam02254 693982012812 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982012813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982012814 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693982012815 putative effector binding pocket; other site 693982012816 dimerization interface [polypeptide binding]; other site 693982012817 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 693982012818 NAD(P) binding site [chemical binding]; other site 693982012819 NADH(P)-binding; Region: NAD_binding_10; pfam13460 693982012820 putative active site [active] 693982012821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982012822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982012823 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 693982012824 substrate binding pocket [chemical binding]; other site 693982012825 dimerization interface [polypeptide binding]; other site 693982012826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 693982012827 short chain dehydrogenase; Provisional; Region: PRK06523 693982012828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982012829 NAD(P) binding site [chemical binding]; other site 693982012830 active site 693982012831 SnoaL-like domain; Region: SnoaL_2; pfam12680 693982012832 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982012833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982012834 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 693982012835 putative effector binding pocket; other site 693982012836 putative dimerization interface [polypeptide binding]; other site 693982012837 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982012838 Transposase domain (DUF772); Region: DUF772; pfam05598 693982012839 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982012840 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 693982012841 putative homodimer interface [polypeptide binding]; other site 693982012842 putative homotetramer interface [polypeptide binding]; other site 693982012843 putative metal binding site [ion binding]; other site 693982012844 putative homodimer-homodimer interface [polypeptide binding]; other site 693982012845 putative allosteric switch controlling residues; other site 693982012846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982012847 putative substrate translocation pore; other site 693982012848 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 693982012849 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 693982012850 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982012851 Walker A/P-loop; other site 693982012852 ATP binding site [chemical binding]; other site 693982012853 Q-loop/lid; other site 693982012854 ABC transporter signature motif; other site 693982012855 Walker B; other site 693982012856 D-loop; other site 693982012857 H-loop/switch region; other site 693982012858 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 693982012859 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 693982012860 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982012861 Walker A/P-loop; other site 693982012862 ATP binding site [chemical binding]; other site 693982012863 Q-loop/lid; other site 693982012864 ABC transporter signature motif; other site 693982012865 Walker B; other site 693982012866 D-loop; other site 693982012867 H-loop/switch region; other site 693982012868 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982012869 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 693982012870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982012871 dimer interface [polypeptide binding]; other site 693982012872 conserved gate region; other site 693982012873 putative PBP binding loops; other site 693982012874 ABC-ATPase subunit interface; other site 693982012875 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982012876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982012877 dimer interface [polypeptide binding]; other site 693982012878 conserved gate region; other site 693982012879 putative PBP binding loops; other site 693982012880 ABC-ATPase subunit interface; other site 693982012881 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982012882 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 693982012883 substrate binding site [chemical binding]; other site 693982012884 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 693982012885 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 693982012886 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982012887 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982012888 DNA-binding site [nucleotide binding]; DNA binding site 693982012889 FCD domain; Region: FCD; pfam07729 693982012890 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693982012891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982012892 Coenzyme A binding pocket [chemical binding]; other site 693982012893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693982012894 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 693982012895 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693982012896 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982012897 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982012898 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 693982012899 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 693982012900 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 693982012901 arginine deiminase; Provisional; Region: PRK01388 693982012902 Predicted membrane protein [Function unknown]; Region: COG4803 693982012903 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 693982012904 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693982012905 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693982012906 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693982012907 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 693982012908 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 693982012909 active site 693982012910 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 693982012911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982012912 motif II; other site 693982012913 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 693982012914 Sulfatase; Region: Sulfatase; pfam00884 693982012915 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982012916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982012917 dimer interface [polypeptide binding]; other site 693982012918 phosphorylation site [posttranslational modification] 693982012919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982012920 ATP binding site [chemical binding]; other site 693982012921 Mg2+ binding site [ion binding]; other site 693982012922 G-X-G motif; other site 693982012923 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 693982012924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982012925 active site 693982012926 phosphorylation site [posttranslational modification] 693982012927 intermolecular recognition site; other site 693982012928 dimerization interface [polypeptide binding]; other site 693982012929 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982012930 DNA binding residues [nucleotide binding] 693982012931 dimerization interface [polypeptide binding]; other site 693982012932 Response regulator receiver domain; Region: Response_reg; pfam00072 693982012933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982012934 active site 693982012935 phosphorylation site [posttranslational modification] 693982012936 intermolecular recognition site; other site 693982012937 dimerization interface [polypeptide binding]; other site 693982012938 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 693982012939 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 693982012940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 693982012941 HWE histidine kinase; Region: HWE_HK; pfam07536 693982012942 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 693982012943 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693982012944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982012945 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 693982012946 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693982012947 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693982012948 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693982012949 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982012950 Transposase; Region: HTH_Tnp_1; cl17663 693982012951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982012952 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693982012953 Predicted transcriptional regulator [Transcription]; Region: COG4957 693982012954 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 693982012955 active site 693982012956 Mn binding site [ion binding]; other site 693982012957 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 693982012958 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693982012959 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 693982012960 active site 693982012961 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 693982012962 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 693982012963 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 693982012964 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693982012965 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 693982012966 active site 693982012967 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 693982012968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982012969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982012970 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693982012971 putative effector binding pocket; other site 693982012972 dimerization interface [polypeptide binding]; other site 693982012973 Isochorismatase family; Region: Isochorismatase; pfam00857 693982012974 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 693982012975 catalytic triad [active] 693982012976 conserved cis-peptide bond; other site 693982012977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 693982012978 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 693982012979 conserved cys residue [active] 693982012980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982012981 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 693982012982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982012983 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 693982012984 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693982012985 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693982012986 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 693982012987 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 693982012988 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 693982012989 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693982012990 NAD(P) binding site [chemical binding]; other site 693982012991 catalytic residues [active] 693982012992 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 693982012993 iron-sulfur cluster [ion binding]; other site 693982012994 [2Fe-2S] cluster binding site [ion binding]; other site 693982012995 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 693982012996 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 693982012997 FAD binding pocket [chemical binding]; other site 693982012998 FAD binding motif [chemical binding]; other site 693982012999 phosphate binding motif [ion binding]; other site 693982013000 beta-alpha-beta structure motif; other site 693982013001 NAD binding pocket [chemical binding]; other site 693982013002 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982013003 catalytic loop [active] 693982013004 iron binding site [ion binding]; other site 693982013005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982013006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693982013008 dimerization interface [polypeptide binding]; other site 693982013009 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 693982013010 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 693982013011 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 693982013012 FAD binding pocket [chemical binding]; other site 693982013013 FAD binding motif [chemical binding]; other site 693982013014 phosphate binding motif [ion binding]; other site 693982013015 NAD binding pocket [chemical binding]; other site 693982013016 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 693982013017 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693982013018 Walker A/P-loop; other site 693982013019 ATP binding site [chemical binding]; other site 693982013020 Q-loop/lid; other site 693982013021 ABC transporter signature motif; other site 693982013022 Walker B; other site 693982013023 D-loop; other site 693982013024 H-loop/switch region; other site 693982013025 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 693982013026 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693982013027 ABC-ATPase subunit interface; other site 693982013028 dimer interface [polypeptide binding]; other site 693982013029 putative PBP binding regions; other site 693982013030 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693982013031 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693982013032 ABC-ATPase subunit interface; other site 693982013033 dimer interface [polypeptide binding]; other site 693982013034 putative PBP binding regions; other site 693982013035 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 693982013036 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 693982013037 intersubunit interface [polypeptide binding]; other site 693982013038 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 693982013039 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693982013040 N-terminal plug; other site 693982013041 ligand-binding site [chemical binding]; other site 693982013042 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693982013043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982013044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982013045 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982013046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982013047 dimer interface [polypeptide binding]; other site 693982013048 conserved gate region; other site 693982013049 putative PBP binding loops; other site 693982013050 ABC-ATPase subunit interface; other site 693982013051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982013052 dimer interface [polypeptide binding]; other site 693982013053 conserved gate region; other site 693982013054 putative PBP binding loops; other site 693982013055 ABC-ATPase subunit interface; other site 693982013056 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693982013057 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 693982013058 Walker A/P-loop; other site 693982013059 ATP binding site [chemical binding]; other site 693982013060 Q-loop/lid; other site 693982013061 ABC transporter signature motif; other site 693982013062 Walker B; other site 693982013063 D-loop; other site 693982013064 H-loop/switch region; other site 693982013065 TOBE domain; Region: TOBE_2; pfam08402 693982013066 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 693982013067 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693982013068 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693982013069 classical (c) SDRs; Region: SDR_c; cd05233 693982013070 NAD(P) binding site [chemical binding]; other site 693982013071 active site 693982013072 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982013073 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982013074 DNA-binding site [nucleotide binding]; DNA binding site 693982013075 FCD domain; Region: FCD; pfam07729 693982013076 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 693982013077 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 693982013078 active site 693982013079 ATP binding site [chemical binding]; other site 693982013080 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 693982013081 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693982013082 inhibitor-cofactor binding pocket; inhibition site 693982013083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982013084 catalytic residue [active] 693982013085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 693982013086 Predicted membrane protein [Function unknown]; Region: COG2261 693982013087 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 693982013088 active site 693982013089 Integrase core domain; Region: rve; pfam00665 693982013090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 693982013091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982013092 Predicted membrane protein [Function unknown]; Region: COG4125 693982013093 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 693982013094 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 693982013095 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982013096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013097 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693982013098 dimerization interface [polypeptide binding]; other site 693982013099 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693982013100 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 693982013101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982013102 Walker A motif; other site 693982013103 ATP binding site [chemical binding]; other site 693982013104 Walker B motif; other site 693982013105 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982013106 Winged helix-turn helix; Region: HTH_29; pfam13551 693982013107 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693982013108 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 693982013109 catalytic residues [active] 693982013110 catalytic nucleophile [active] 693982013111 Recombinase; Region: Recombinase; pfam07508 693982013112 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693982013113 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 693982013114 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693982013115 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693982013116 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 693982013117 Transmembrane secretion effector; Region: MFS_3; pfam05977 693982013118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982013119 putative substrate translocation pore; other site 693982013120 Predicted membrane protein [Function unknown]; Region: COG2259 693982013121 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 693982013122 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 693982013123 active site 693982013124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4317 693982013125 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 693982013126 Isochorismatase family; Region: Isochorismatase; pfam00857 693982013127 catalytic triad [active] 693982013128 dimer interface [polypeptide binding]; other site 693982013129 conserved cis-peptide bond; other site 693982013130 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982013131 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693982013132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982013133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982013134 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693982013135 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982013136 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982013137 Helix-turn-helix domain; Region: HTH_18; pfam12833 693982013138 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982013139 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982013140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013141 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693982013142 putative effector binding pocket; other site 693982013143 dimerization interface [polypeptide binding]; other site 693982013144 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 693982013145 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 693982013146 acetylornithine deacetylase; Provisional; Region: PRK07522 693982013147 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 693982013148 metal binding site [ion binding]; metal-binding site 693982013149 putative dimer interface [polypeptide binding]; other site 693982013150 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 693982013151 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693982013152 putative ligand binding site [chemical binding]; other site 693982013153 NAD binding site [chemical binding]; other site 693982013154 dimerization interface [polypeptide binding]; other site 693982013155 catalytic site [active] 693982013156 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 693982013157 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693982013158 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693982013159 NAD(P) binding site [chemical binding]; other site 693982013160 catalytic residues [active] 693982013161 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 693982013162 tartrate dehydrogenase; Region: TTC; TIGR02089 693982013163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 693982013164 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982013165 Homeodomain-like domain; Region: HTH_32; pfam13565 693982013166 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693982013167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693982013168 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693982013169 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982013170 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 693982013171 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 693982013172 putative acetyltransferase; Provisional; Region: PRK03624 693982013173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982013174 Coenzyme A binding pocket [chemical binding]; other site 693982013175 hypothetical protein; Provisional; Region: PRK05965 693982013176 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693982013177 inhibitor-cofactor binding pocket; inhibition site 693982013178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982013179 catalytic residue [active] 693982013180 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982013181 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 693982013182 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982013183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982013184 dimer interface [polypeptide binding]; other site 693982013185 conserved gate region; other site 693982013186 putative PBP binding loops; other site 693982013187 ABC-ATPase subunit interface; other site 693982013188 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982013189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982013190 dimer interface [polypeptide binding]; other site 693982013191 conserved gate region; other site 693982013192 ABC-ATPase subunit interface; other site 693982013193 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 693982013194 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982013195 Walker A/P-loop; other site 693982013196 ATP binding site [chemical binding]; other site 693982013197 Q-loop/lid; other site 693982013198 ABC transporter signature motif; other site 693982013199 Walker B; other site 693982013200 D-loop; other site 693982013201 H-loop/switch region; other site 693982013202 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982013203 Walker A/P-loop; other site 693982013204 ATP binding site [chemical binding]; other site 693982013205 Q-loop/lid; other site 693982013206 ABC transporter signature motif; other site 693982013207 Walker B; other site 693982013208 D-loop; other site 693982013209 H-loop/switch region; other site 693982013210 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982013211 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982013212 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982013213 putative DNA binding site [nucleotide binding]; other site 693982013214 putative Zn2+ binding site [ion binding]; other site 693982013215 AsnC family; Region: AsnC_trans_reg; pfam01037 693982013216 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982013217 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693982013218 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 693982013219 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 693982013220 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 693982013221 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 693982013222 tetramer interface [polypeptide binding]; other site 693982013223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982013224 catalytic residue [active] 693982013225 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 693982013226 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 693982013227 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693982013228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982013229 motif II; other site 693982013230 Family description; Region: DsbD_2; pfam13386 693982013231 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 693982013232 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 693982013233 Cytochrome c; Region: Cytochrom_C; pfam00034 693982013234 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693982013235 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 693982013236 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 693982013237 Low-spin heme binding site [chemical binding]; other site 693982013238 D-pathway; other site 693982013239 Putative water exit pathway; other site 693982013240 Binuclear center (active site) [active] 693982013241 K-pathway; other site 693982013242 Putative proton exit pathway; other site 693982013243 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 693982013244 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 693982013245 ring oligomerisation interface [polypeptide binding]; other site 693982013246 ATP/Mg binding site [chemical binding]; other site 693982013247 stacking interactions; other site 693982013248 hinge regions; other site 693982013249 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 693982013250 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 693982013251 substrate-cofactor binding pocket; other site 693982013252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982013253 catalytic residue [active] 693982013254 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 693982013255 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 693982013256 Cu(I) binding site [ion binding]; other site 693982013257 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 693982013258 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693982013259 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693982013260 active site 693982013261 metal binding site [ion binding]; metal-binding site 693982013262 Cytochrome c [Energy production and conversion]; Region: COG3258 693982013263 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 693982013264 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693982013265 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 693982013266 Cytochrome c; Region: Cytochrom_C; cl11414 693982013267 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 693982013268 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 693982013269 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 693982013270 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982013271 DNA-binding site [nucleotide binding]; DNA binding site 693982013272 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693982013273 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693982013274 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693982013275 catalytic residue [active] 693982013276 Cupin domain; Region: Cupin_2; pfam07883 693982013277 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982013278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982013279 NAD(P) binding site [chemical binding]; other site 693982013280 active site 693982013281 putative transcriptional regulator; Provisional; Region: PRK11640 693982013282 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982013283 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 693982013284 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 693982013285 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693982013286 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982013287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982013288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693982013290 dimerization interface [polypeptide binding]; other site 693982013291 methionine sulfoxide reductase B; Provisional; Region: PRK00222 693982013292 SelR domain; Region: SelR; pfam01641 693982013293 methionine sulfoxide reductase A; Provisional; Region: PRK14054 693982013294 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 693982013295 active site 693982013296 catalytic residues [active] 693982013297 Transglycosylase; Region: Transgly; pfam00912 693982013298 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 693982013299 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693982013300 BA14K-like protein; Region: BA14K; pfam07886 693982013301 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 693982013302 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 693982013303 Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004 693982013304 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 693982013305 transmembrane helices; other site 693982013306 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693982013307 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693982013308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 693982013309 Predicted nucleotide kinase (related to CMP and AMP kinases) [Nucleotide transport and metabolism]; Region: COG1936 693982013310 AAA domain; Region: AAA_17; pfam13207 693982013311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982013312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013313 LysR substrate binding domain; Region: LysR_substrate; pfam03466 693982013314 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 693982013315 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693982013316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982013317 putative substrate translocation pore; other site 693982013318 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693982013319 hypothetical protein; Provisional; Region: PRK06834 693982013320 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693982013321 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982013322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982013324 dimerization interface [polypeptide binding]; other site 693982013325 EamA-like transporter family; Region: EamA; pfam00892 693982013326 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693982013327 EamA-like transporter family; Region: EamA; pfam00892 693982013328 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693982013329 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693982013330 ligand binding site [chemical binding]; other site 693982013331 flexible hinge region; other site 693982013332 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 693982013333 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 693982013334 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 693982013335 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 693982013336 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982013337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013338 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 693982013339 substrate binding pocket [chemical binding]; other site 693982013340 dimerization interface [polypeptide binding]; other site 693982013341 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693982013342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982013343 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 693982013344 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693982013345 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693982013346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982013347 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693982013348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693982013349 Transposase; Region: HTH_Tnp_1; pfam01527 693982013350 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982013351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013352 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 693982013353 substrate binding pocket [chemical binding]; other site 693982013354 dimerization interface [polypeptide binding]; other site 693982013355 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 693982013356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982013357 NAD(P) binding site [chemical binding]; other site 693982013358 active site 693982013359 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693982013360 Predicted transcriptional regulators [Transcription]; Region: COG1733 693982013361 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 693982013362 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 693982013363 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 693982013364 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693982013365 catalytic residues [active] 693982013366 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 693982013367 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 693982013368 glutaminase active site [active] 693982013369 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 693982013370 dimer interface [polypeptide binding]; other site 693982013371 active site 693982013372 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 693982013373 dimer interface [polypeptide binding]; other site 693982013374 active site 693982013375 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693982013376 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982013377 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693982013378 Protein export membrane protein; Region: SecD_SecF; cl14618 693982013379 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 693982013380 putative active site [active] 693982013381 putative catalytic site [active] 693982013382 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 693982013383 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 693982013384 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693982013385 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 693982013386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982013387 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693982013388 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693982013389 Transposase; Region: HTH_Tnp_1; pfam01527 693982013390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693982013391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982013392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013393 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 693982013394 putative substrate binding pocket [chemical binding]; other site 693982013395 putative dimerization interface [polypeptide binding]; other site 693982013396 Nodulation protein A (NodA); Region: NodA; pfam02474 693982013397 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 693982013398 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 693982013399 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 693982013400 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 693982013401 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 693982013402 DXD motif; other site 693982013403 nodulation factor exporter subunit NodI; Provisional; Region: PRK13536 693982013404 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693982013405 Walker A/P-loop; other site 693982013406 ATP binding site [chemical binding]; other site 693982013407 Q-loop/lid; other site 693982013408 ABC transporter signature motif; other site 693982013409 Walker B; other site 693982013410 D-loop; other site 693982013411 H-loop/switch region; other site 693982013412 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693982013413 ABC-2 type transporter, NodJ family; Region: nodJ; TIGR01291 693982013414 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 693982013415 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 693982013416 CysD dimerization site [polypeptide binding]; other site 693982013417 G1 box; other site 693982013418 putative GEF interaction site [polypeptide binding]; other site 693982013419 GTP/Mg2+ binding site [chemical binding]; other site 693982013420 Switch I region; other site 693982013421 G2 box; other site 693982013422 G3 box; other site 693982013423 Switch II region; other site 693982013424 G4 box; other site 693982013425 G5 box; other site 693982013426 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 693982013427 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 693982013428 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 693982013429 ligand-binding site [chemical binding]; other site 693982013430 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 693982013431 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693982013432 Active Sites [active] 693982013433 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 693982013434 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 693982013435 NAD(P) binding site [chemical binding]; other site 693982013436 homotetramer interface [polypeptide binding]; other site 693982013437 homodimer interface [polypeptide binding]; other site 693982013438 active site 693982013439 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 693982013440 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693982013441 dimer interface [polypeptide binding]; other site 693982013442 active site 693982013443 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 693982013444 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 693982013445 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982013446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013447 The C-terminal substrate binding of LysR-type symbiotic regulator SyrM, which activates expression of nodulation gene NodD3, contains the type 2 periplasmic binding fold; Region: PBP2_SyrM; cd08467 693982013448 putative substrate binding pocket [chemical binding]; other site 693982013449 putative dimerization interface [polypeptide binding]; other site 693982013450 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693982013451 Transposase; Region: HTH_Tnp_1; pfam01527 693982013452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982013453 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693982013454 Transposase; Region: HTH_Tnp_1; pfam01527 693982013455 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982013456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013457 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 693982013458 putative substrate binding pocket [chemical binding]; other site 693982013459 putative dimerization interface [polypeptide binding]; other site 693982013460 Exopolysaccharide production repressor; Region: SyrA; pfam11089 693982013461 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 693982013462 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 693982013463 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 693982013464 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 693982013465 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 693982013466 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 693982013467 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 693982013468 MoFe protein beta/alpha subunit interactions; other site 693982013469 Beta subunit P cluster binding residues; other site 693982013470 MoFe protein beta subunit/Fe protein contacts; other site 693982013471 MoFe protein dimer/ dimer interactions; other site 693982013472 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 693982013473 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 693982013474 MoFe protein alpha/beta subunit interactions; other site 693982013475 Alpha subunit P cluster binding residues; other site 693982013476 FeMoco binding residues [chemical binding]; other site 693982013477 MoFe protein alpha subunit/Fe protein contacts; other site 693982013478 MoFe protein dimer/ dimer interactions; other site 693982013479 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 693982013480 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 693982013481 Nucleotide-binding sites [chemical binding]; other site 693982013482 Walker A motif; other site 693982013483 Switch I region of nucleotide binding site; other site 693982013484 Fe4S4 binding sites [ion binding]; other site 693982013485 Switch II region of nucleotide binding site; other site 693982013486 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 693982013487 Ligand binding site [chemical binding]; other site 693982013488 Electron transfer flavoprotein domain; Region: ETF; pfam01012 693982013489 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 693982013490 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 693982013491 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 693982013492 oxidoreductase; Provisional; Region: PRK10015 693982013493 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693982013494 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 693982013495 Nif-specific regulatory protein; Region: nifA; TIGR01817 693982013496 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 693982013497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982013498 Walker A motif; other site 693982013499 ATP binding site [chemical binding]; other site 693982013500 Walker B motif; other site 693982013501 arginine finger; other site 693982013502 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693982013503 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 693982013504 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693982013505 FeS/SAM binding site; other site 693982013506 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 693982013507 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693982013508 Nitrogen fixation protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NifU; COG5554 693982013509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 693982013510 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982013511 Homeodomain-like domain; Region: HTH_32; pfam13565 693982013512 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693982013513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693982013514 Transposase; Region: HTH_Tnp_1; cl17663 693982013515 succinic semialdehyde dehydrogenase; Region: PLN02278 693982013516 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 693982013517 tetramerization interface [polypeptide binding]; other site 693982013518 NAD(P) binding site [chemical binding]; other site 693982013519 catalytic residues [active] 693982013520 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693982013521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982013522 Walker A/P-loop; other site 693982013523 ATP binding site [chemical binding]; other site 693982013524 Q-loop/lid; other site 693982013525 ABC transporter signature motif; other site 693982013526 Walker B; other site 693982013527 D-loop; other site 693982013528 H-loop/switch region; other site 693982013529 TOBE domain; Region: TOBE_2; pfam08402 693982013530 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982013531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982013532 putative PBP binding loops; other site 693982013533 ABC-ATPase subunit interface; other site 693982013534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982013535 dimer interface [polypeptide binding]; other site 693982013536 conserved gate region; other site 693982013537 putative PBP binding loops; other site 693982013538 ABC-ATPase subunit interface; other site 693982013539 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 693982013540 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693982013541 NIPSNAP; Region: NIPSNAP; pfam07978 693982013542 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693982013543 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 693982013544 NAD(P) binding site [chemical binding]; other site 693982013545 catalytic residues [active] 693982013546 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 693982013547 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 693982013548 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 693982013549 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693982013550 Amino acid synthesis; Region: AA_synth; pfam06684 693982013551 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982013552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982013553 DNA-binding site [nucleotide binding]; DNA binding site 693982013554 FCD domain; Region: FCD; pfam07729 693982013555 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693982013556 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982013557 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693982013558 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693982013559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 693982013560 Homeodomain-like domain; Region: HTH_32; pfam13565 693982013561 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693982013562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693982013563 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982013564 Transposase domain (DUF772); Region: DUF772; pfam05598 693982013565 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982013566 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 693982013567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982013568 S-adenosylmethionine binding site [chemical binding]; other site 693982013569 maltose O-acetyltransferase; Provisional; Region: PRK10092 693982013570 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 693982013571 active site 693982013572 substrate binding site [chemical binding]; other site 693982013573 trimer interface [polypeptide binding]; other site 693982013574 CoA binding site [chemical binding]; other site 693982013575 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 693982013576 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693982013577 metal-binding site [ion binding] 693982013578 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693982013579 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 693982013580 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693982013581 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693982013582 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 693982013583 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 693982013584 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 693982013585 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 693982013586 Low-spin heme binding site [chemical binding]; other site 693982013587 Putative water exit pathway; other site 693982013588 Binuclear center (active site) [active] 693982013589 Putative proton exit pathway; other site 693982013590 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 693982013591 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693982013592 ligand binding site [chemical binding]; other site 693982013593 flexible hinge region; other site 693982013594 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693982013595 putative switch regulator; other site 693982013596 non-specific DNA interactions [nucleotide binding]; other site 693982013597 DNA binding site [nucleotide binding] 693982013598 sequence specific DNA binding site [nucleotide binding]; other site 693982013599 putative cAMP binding site [chemical binding]; other site 693982013600 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 693982013601 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 693982013602 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 693982013603 putative active site [active] 693982013604 putative NTP binding site [chemical binding]; other site 693982013605 putative nucleic acid binding site [nucleotide binding]; other site 693982013606 Transposase, Mutator family; Region: Transposase_mut; pfam00872 693982013607 Transposase domain (DUF772); Region: DUF772; pfam05598 693982013608 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982013609 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693982013610 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 693982013611 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 693982013612 putative active site [active] 693982013613 putative NTP binding site [chemical binding]; other site 693982013614 putative nucleic acid binding site [nucleotide binding]; other site 693982013615 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 693982013616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693982013617 Transposase; Region: HTH_Tnp_1; pfam01527 693982013618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982013619 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693982013620 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693982013621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982013622 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 693982013623 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693982013624 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693982013625 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693982013626 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 693982013627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982013628 Walker A motif; other site 693982013629 ATP binding site [chemical binding]; other site 693982013630 Walker B motif; other site 693982013631 Transposase, Mutator family; Region: Transposase_mut; pfam00872 693982013632 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982013633 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013634 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 693982013635 putative substrate binding pocket [chemical binding]; other site 693982013636 putative dimerization interface [polypeptide binding]; other site 693982013637 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 693982013638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693982013639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982013640 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 693982013641 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 693982013642 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 693982013643 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 693982013644 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 693982013645 NAD(P) binding site [chemical binding]; other site 693982013646 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 693982013647 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693982013648 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693982013649 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 693982013650 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693982013651 FeS/SAM binding site; other site 693982013652 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 693982013653 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 693982013654 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 693982013655 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693982013656 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 693982013657 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693982013658 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982013659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982013660 dimer interface [polypeptide binding]; other site 693982013661 conserved gate region; other site 693982013662 putative PBP binding loops; other site 693982013663 ABC-ATPase subunit interface; other site 693982013664 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982013665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982013666 dimer interface [polypeptide binding]; other site 693982013667 conserved gate region; other site 693982013668 putative PBP binding loops; other site 693982013669 ABC-ATPase subunit interface; other site 693982013670 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693982013671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982013672 Walker A/P-loop; other site 693982013673 ATP binding site [chemical binding]; other site 693982013674 Q-loop/lid; other site 693982013675 ABC transporter signature motif; other site 693982013676 Walker B; other site 693982013677 D-loop; other site 693982013678 H-loop/switch region; other site 693982013679 TOBE domain; Region: TOBE_2; pfam08402 693982013680 Transposase; Region: HTH_Tnp_1; pfam01527 693982013681 putative transposase OrfB; Reviewed; Region: PHA02517 693982013682 HTH-like domain; Region: HTH_21; pfam13276 693982013683 Integrase core domain; Region: rve; pfam00665 693982013684 Integrase core domain; Region: rve_3; pfam13683 693982013685 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982013686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 693982013687 Uncharacterized conserved protein [Function unknown]; Region: COG5476 693982013688 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 693982013689 MlrC C-terminus; Region: MlrC_C; pfam07171 693982013690 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 693982013691 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982013692 Walker A/P-loop; other site 693982013693 ATP binding site [chemical binding]; other site 693982013694 Q-loop/lid; other site 693982013695 ABC transporter signature motif; other site 693982013696 Walker B; other site 693982013697 D-loop; other site 693982013698 H-loop/switch region; other site 693982013699 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 693982013700 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 693982013701 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982013702 Walker A/P-loop; other site 693982013703 ATP binding site [chemical binding]; other site 693982013704 Q-loop/lid; other site 693982013705 ABC transporter signature motif; other site 693982013706 Walker B; other site 693982013707 D-loop; other site 693982013708 H-loop/switch region; other site 693982013709 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 693982013710 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 693982013711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982013712 dimer interface [polypeptide binding]; other site 693982013713 conserved gate region; other site 693982013714 putative PBP binding loops; other site 693982013715 ABC-ATPase subunit interface; other site 693982013716 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982013717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982013718 dimer interface [polypeptide binding]; other site 693982013719 conserved gate region; other site 693982013720 putative PBP binding loops; other site 693982013721 ABC-ATPase subunit interface; other site 693982013722 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982013723 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 693982013724 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 693982013725 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 693982013726 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 693982013727 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 693982013728 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 693982013729 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 693982013730 acyl-activating enzyme (AAE) consensus motif; other site 693982013731 putative AMP binding site [chemical binding]; other site 693982013732 putative active site [active] 693982013733 putative CoA binding site [chemical binding]; other site 693982013734 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 693982013735 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693982013736 substrate binding site [chemical binding]; other site 693982013737 oxyanion hole (OAH) forming residues; other site 693982013738 trimer interface [polypeptide binding]; other site 693982013739 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 693982013740 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 693982013741 Bacterial transcriptional regulator; Region: IclR; pfam01614 693982013742 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 693982013743 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 693982013744 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 693982013745 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 693982013746 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 693982013747 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 693982013748 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982013749 Predicted deacylase [General function prediction only]; Region: COG3608 693982013750 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 693982013751 active site 693982013752 Zn binding site [ion binding]; other site 693982013753 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 693982013754 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982013755 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982013756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982013757 dimer interface [polypeptide binding]; other site 693982013758 conserved gate region; other site 693982013759 putative PBP binding loops; other site 693982013760 ABC-ATPase subunit interface; other site 693982013761 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982013762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982013763 dimer interface [polypeptide binding]; other site 693982013764 conserved gate region; other site 693982013765 putative PBP binding loops; other site 693982013766 ABC-ATPase subunit interface; other site 693982013767 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693982013768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982013769 Walker A/P-loop; other site 693982013770 ATP binding site [chemical binding]; other site 693982013771 Q-loop/lid; other site 693982013772 ABC transporter signature motif; other site 693982013773 Walker B; other site 693982013774 D-loop; other site 693982013775 H-loop/switch region; other site 693982013776 TOBE domain; Region: TOBE_2; pfam08402 693982013777 Transposase; Region: HTH_Tnp_1; cl17663 693982013778 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 693982013779 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 693982013780 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693982013781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982013782 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 693982013783 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693982013784 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693982013785 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982013786 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693982013787 Transposase; Region: HTH_Tnp_1; pfam01527 693982013788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693982013789 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 693982013790 Int/Topo IB signature motif; other site 693982013791 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 693982013792 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 693982013793 Int/Topo IB signature motif; other site 693982013794 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 693982013795 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 693982013796 Int/Topo IB signature motif; other site 693982013797 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 693982013798 Putative transposase; Region: Y2_Tnp; pfam04986 693982013799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693982013800 Transposase; Region: HTH_Tnp_1; pfam01527 693982013801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982013802 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693982013803 Transposase; Region: HTH_Tnp_1; pfam01527 693982013804 putative transposase OrfB; Reviewed; Region: PHA02517 693982013805 HTH-like domain; Region: HTH_21; pfam13276 693982013806 Integrase core domain; Region: rve; pfam00665 693982013807 Integrase core domain; Region: rve_3; pfam13683 693982013808 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 693982013809 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693982013810 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 693982013811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982013812 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 693982013813 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693982013814 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 693982013815 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 693982013816 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 693982013817 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 693982013818 NAD(P) binding site [chemical binding]; other site 693982013819 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 693982013820 nucleotide binding site [chemical binding]; other site 693982013821 substrate binding site [chemical binding]; other site 693982013822 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 693982013823 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693982013824 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693982013825 ligand binding site [chemical binding]; other site 693982013826 flexible hinge region; other site 693982013827 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 693982013828 Ligand Binding Site [chemical binding]; other site 693982013829 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693982013830 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693982013831 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 693982013832 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 693982013833 dimer interface [polypeptide binding]; other site 693982013834 active site 693982013835 catalytic residue [active] 693982013836 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 693982013837 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 693982013838 pyridoxal binding site [chemical binding]; other site 693982013839 dimer interface [polypeptide binding]; other site 693982013840 ATP binding site [chemical binding]; other site 693982013841 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 693982013842 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 693982013843 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 693982013844 FAD binding pocket [chemical binding]; other site 693982013845 FAD binding motif [chemical binding]; other site 693982013846 phosphate binding motif [ion binding]; other site 693982013847 beta-alpha-beta structure motif; other site 693982013848 NAD binding pocket [chemical binding]; other site 693982013849 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982013850 catalytic loop [active] 693982013851 iron binding site [ion binding]; other site 693982013852 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 693982013853 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 693982013854 [2Fe-2S] cluster binding site [ion binding]; other site 693982013855 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 693982013856 putative alpha subunit interface [polypeptide binding]; other site 693982013857 putative active site [active] 693982013858 putative substrate binding site [chemical binding]; other site 693982013859 Fe binding site [ion binding]; other site 693982013860 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 693982013861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013862 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982013863 dimerization interface [polypeptide binding]; other site 693982013864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693982013865 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693982013866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982013867 S-adenosylmethionine binding site [chemical binding]; other site 693982013868 Predicted transcriptional regulator [Transcription]; Region: COG4957 693982013869 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 693982013870 nudix motif; other site 693982013871 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693982013872 DNA-binding site [nucleotide binding]; DNA binding site 693982013873 RNA-binding motif; other site 693982013874 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982013875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982013876 non-specific DNA binding site [nucleotide binding]; other site 693982013877 salt bridge; other site 693982013878 sequence-specific DNA binding site [nucleotide binding]; other site 693982013879 Uncharacterized conserved protein [Function unknown]; Region: COG5556 693982013880 acyl carrier protein; Provisional; Region: acpP; PRK00982 693982013881 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 693982013882 oligomerisation interface [polypeptide binding]; other site 693982013883 mobile loop; other site 693982013884 roof hairpin; other site 693982013885 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 693982013886 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 693982013887 ring oligomerisation interface [polypeptide binding]; other site 693982013888 ATP/Mg binding site [chemical binding]; other site 693982013889 stacking interactions; other site 693982013890 hinge regions; other site 693982013891 Transposase domain (DUF772); Region: DUF772; pfam05598 693982013892 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693982013893 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982013894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982013895 non-specific DNA binding site [nucleotide binding]; other site 693982013896 salt bridge; other site 693982013897 sequence-specific DNA binding site [nucleotide binding]; other site 693982013898 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 693982013899 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 693982013900 active site 693982013901 zinc binding site [ion binding]; other site 693982013902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982013903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693982013904 putative substrate translocation pore; other site 693982013905 LabA_like proteins; Region: LabA_like/DUF88; cl10034 693982013906 putative metal binding site [ion binding]; other site 693982013907 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 693982013908 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693982013909 Ligand Binding Site [chemical binding]; other site 693982013910 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693982013911 Ligand Binding Site [chemical binding]; other site 693982013912 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693982013913 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 693982013914 Sulfate transporter family; Region: Sulfate_transp; pfam00916 693982013915 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 693982013916 Uncharacterized conserved protein [Function unknown]; Region: COG1432 693982013917 LabA_like proteins; Region: LabA; cd10911 693982013918 putative metal binding site [ion binding]; other site 693982013919 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 693982013920 RNA polymerase sigma factor; Provisional; Region: PRK12512 693982013921 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982013922 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982013923 DNA binding residues [nucleotide binding] 693982013924 Predicted integral membrane protein [Function unknown]; Region: COG5572 693982013925 hypothetical protein; Provisional; Region: PRK05409 693982013926 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 693982013927 Predicted membrane protein [Function unknown]; Region: COG2259 693982013928 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982013929 Winged helix-turn helix; Region: HTH_29; pfam13551 693982013930 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693982013931 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 693982013932 catalytic residues [active] 693982013933 catalytic nucleophile [active] 693982013934 Recombinase; Region: Recombinase; pfam07508 693982013935 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693982013936 HTH-like domain; Region: HTH_21; pfam13276 693982013937 Integrase core domain; Region: rve; pfam00665 693982013938 Transposase; Region: HTH_Tnp_1; cl17663 693982013939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693982013940 Uncharacterized conserved protein [Function unknown]; Region: COG3246 693982013941 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 693982013942 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 693982013943 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 693982013944 nudix motif; other site 693982013945 CheB methylesterase; Region: CheB_methylest; pfam01339 693982013946 Cupin; Region: Cupin_6; pfam12852 693982013947 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693982013948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982013949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982013950 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 693982013951 dimer interface [polypeptide binding]; other site 693982013952 FMN binding site [chemical binding]; other site 693982013953 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 693982013954 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 693982013955 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 693982013956 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 693982013957 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 693982013958 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 693982013959 putative NAD(P) binding site [chemical binding]; other site 693982013960 Cupin domain; Region: Cupin_2; cl17218 693982013961 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 693982013962 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 693982013963 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 693982013964 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 693982013965 Homeodomain-like domain; Region: HTH_23; cl17451 693982013966 Predicted acetyltransferase [General function prediction only]; Region: COG3153 693982013967 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 693982013968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982013969 NAD(P) binding site [chemical binding]; other site 693982013970 active site 693982013971 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 693982013972 Isochorismatase family; Region: Isochorismatase; pfam00857 693982013973 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 693982013974 catalytic triad [active] 693982013975 dimer interface [polypeptide binding]; other site 693982013976 conserved cis-peptide bond; other site 693982013977 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982013978 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013979 LysR substrate binding domain; Region: LysR_substrate; pfam03466 693982013980 dimerization interface [polypeptide binding]; other site 693982013981 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982013982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982013983 LysR substrate binding domain; Region: LysR_substrate; pfam03466 693982013984 dimerization interface [polypeptide binding]; other site 693982013985 Pirin-related protein [General function prediction only]; Region: COG1741 693982013986 Pirin; Region: Pirin; pfam02678 693982013987 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 693982013988 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 693982013989 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 693982013990 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 693982013991 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 693982013992 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 693982013993 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693982013994 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693982013995 classical (c) SDRs; Region: SDR_c; cd05233 693982013996 NAD(P) binding site [chemical binding]; other site 693982013997 active site 693982013998 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 693982013999 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 693982014000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982014001 NAD(P) binding site [chemical binding]; other site 693982014002 active site 693982014003 Predicted membrane protein [Function unknown]; Region: COG2259 693982014004 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 693982014005 classical (c) SDRs; Region: SDR_c; cd05233 693982014006 NAD(P) binding site [chemical binding]; other site 693982014007 active site 693982014008 short chain dehydrogenase; Provisional; Region: PRK06180 693982014009 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 693982014010 NADP binding site [chemical binding]; other site 693982014011 active site 693982014012 steroid binding site; other site 693982014013 Uncharacterized conserved protein [Function unknown]; Region: COG1359 693982014014 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 693982014015 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 693982014016 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 693982014017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982014018 NAD(P) binding site [chemical binding]; other site 693982014019 active site 693982014020 Cupin; Region: Cupin_6; pfam12852 693982014021 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693982014022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982014023 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 693982014024 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 693982014025 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 693982014026 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 693982014027 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982014028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982014029 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 693982014030 putative effector binding pocket; other site 693982014031 putative dimerization interface [polypeptide binding]; other site 693982014032 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693982014033 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 693982014034 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982014035 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 693982014036 putative dimerization interface [polypeptide binding]; other site 693982014037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982014038 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982014039 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 693982014040 DNA-binding site [nucleotide binding]; DNA binding site 693982014041 FCD domain; Region: FCD; pfam07729 693982014042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693982014043 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693982014044 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693982014045 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693982014046 multiple promoter invertase; Provisional; Region: mpi; PRK13413 693982014047 catalytic residues [active] 693982014048 catalytic nucleophile [active] 693982014049 Presynaptic Site I dimer interface [polypeptide binding]; other site 693982014050 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693982014051 Synaptic Flat tetramer interface [polypeptide binding]; other site 693982014052 Synaptic Site I dimer interface [polypeptide binding]; other site 693982014053 DNA binding site [nucleotide binding] 693982014054 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 693982014055 DNA-binding interface [nucleotide binding]; DNA binding site 693982014056 Protein of unknown function (DUF418); Region: DUF418; pfam04235 693982014057 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693982014058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982014059 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 693982014060 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693982014061 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693982014062 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 693982014063 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693982014064 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 693982014065 active site 693982014066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982014067 DNA-binding site [nucleotide binding]; DNA binding site 693982014068 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 693982014069 UTRA domain; Region: UTRA; pfam07702 693982014070 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 693982014071 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982014072 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 693982014073 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 693982014074 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982014075 Walker A/P-loop; other site 693982014076 ATP binding site [chemical binding]; other site 693982014077 Q-loop/lid; other site 693982014078 ABC transporter signature motif; other site 693982014079 Walker B; other site 693982014080 D-loop; other site 693982014081 H-loop/switch region; other site 693982014082 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982014083 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 693982014084 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982014085 Walker A/P-loop; other site 693982014086 ATP binding site [chemical binding]; other site 693982014087 Q-loop/lid; other site 693982014088 ABC transporter signature motif; other site 693982014089 Walker B; other site 693982014090 D-loop; other site 693982014091 H-loop/switch region; other site 693982014092 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982014093 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982014094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014095 dimer interface [polypeptide binding]; other site 693982014096 conserved gate region; other site 693982014097 putative PBP binding loops; other site 693982014098 ABC-ATPase subunit interface; other site 693982014099 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982014100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014101 dimer interface [polypeptide binding]; other site 693982014102 conserved gate region; other site 693982014103 putative PBP binding loops; other site 693982014104 ABC-ATPase subunit interface; other site 693982014105 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693982014106 active site 693982014107 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982014108 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 693982014109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982014110 homodimer interface [polypeptide binding]; other site 693982014111 catalytic residue [active] 693982014112 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 693982014113 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 693982014114 active site 693982014115 dimer interface [polypeptide binding]; other site 693982014116 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 693982014117 Ligand Binding Site [chemical binding]; other site 693982014118 Molecular Tunnel; other site 693982014119 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 693982014120 active site 693982014121 substrate binding site [chemical binding]; other site 693982014122 cosubstrate binding site; other site 693982014123 catalytic site [active] 693982014124 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 693982014125 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 693982014126 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 693982014127 active site 693982014128 metal-binding site 693982014129 aspartate aminotransferase; Provisional; Region: PRK05764 693982014130 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982014131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982014132 homodimer interface [polypeptide binding]; other site 693982014133 catalytic residue [active] 693982014134 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 693982014135 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693982014136 tetramer interface [polypeptide binding]; other site 693982014137 active site 693982014138 Mg2+/Mn2+ binding site [ion binding]; other site 693982014139 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 693982014140 MobA/MobL family; Region: MobA_MobL; pfam03389 693982014141 AAA domain; Region: AAA_30; pfam13604 693982014142 Family description; Region: UvrD_C_2; pfam13538 693982014143 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 693982014144 putative metal binding site [ion binding]; other site 693982014145 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 693982014146 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 693982014147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982014148 non-specific DNA binding site [nucleotide binding]; other site 693982014149 sequence-specific DNA binding site [nucleotide binding]; other site 693982014150 salt bridge; other site 693982014151 Predicted transcriptional regulator [Transcription]; Region: COG2944 693982014152 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693982014153 Magnesium ion binding site [ion binding]; other site 693982014154 Helix-turn-helix domain; Region: HTH_36; pfam13730 693982014155 Uncharacterized secreted protein [Function unknown]; Region: COG5430 693982014156 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 693982014157 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 693982014158 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693982014159 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 693982014160 PapC C-terminal domain; Region: PapC_C; pfam13953 693982014161 Spore Coat Protein U domain; Region: SCPU; pfam05229 693982014162 Uncharacterized secreted protein [Function unknown]; Region: COG5430 693982014163 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 693982014164 Predicted transcriptional regulator [Transcription]; Region: COG3905 693982014165 Protein of unknown function (DUF968); Region: DUF968; pfam06147 693982014166 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 693982014167 Helix-turn-helix domain; Region: HTH_36; pfam13730 693982014168 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 693982014169 chorismate binding enzyme; Region: Chorismate_bind; cl10555 693982014170 transposase; Validated; Region: PRK08181 693982014171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982014172 Walker A motif; other site 693982014173 ATP binding site [chemical binding]; other site 693982014174 Walker B motif; other site 693982014175 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982014176 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982014177 DNA binding site [nucleotide binding] 693982014178 domain linker motif; other site 693982014179 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 693982014180 putative dimerization interface [polypeptide binding]; other site 693982014181 putative ligand binding site [chemical binding]; other site 693982014182 Isochorismatase family; Region: Isochorismatase; pfam00857 693982014183 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 693982014184 catalytic triad [active] 693982014185 conserved cis-peptide bond; other site 693982014186 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 693982014187 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 693982014188 intersubunit interface [polypeptide binding]; other site 693982014189 active site 693982014190 Zn2+ binding site [ion binding]; other site 693982014191 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 693982014192 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 693982014193 N- and C-terminal domain interface [polypeptide binding]; other site 693982014194 putative active site [active] 693982014195 putative MgATP binding site [chemical binding]; other site 693982014196 putative catalytic site [active] 693982014197 metal binding site [ion binding]; metal-binding site 693982014198 putative carbohydrate binding site [chemical binding]; other site 693982014199 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693982014200 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 693982014201 DNA interaction; other site 693982014202 Metal-binding active site; metal-binding site 693982014203 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982014204 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982014205 TM-ABC transporter signature motif; other site 693982014206 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982014207 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982014208 TM-ABC transporter signature motif; other site 693982014209 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982014210 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982014211 Walker A/P-loop; other site 693982014212 ATP binding site [chemical binding]; other site 693982014213 Q-loop/lid; other site 693982014214 ABC transporter signature motif; other site 693982014215 Walker B; other site 693982014216 D-loop; other site 693982014217 H-loop/switch region; other site 693982014218 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982014219 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 693982014220 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693982014221 ligand binding site [chemical binding]; other site 693982014222 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982014223 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 693982014224 dimerization interface [polypeptide binding]; other site 693982014225 ligand binding site [chemical binding]; other site 693982014226 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 693982014227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982014228 Coenzyme A binding pocket [chemical binding]; other site 693982014229 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 693982014230 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 693982014231 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 693982014232 active site 693982014233 dimer interface [polypeptide binding]; other site 693982014234 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 693982014235 Ligand Binding Site [chemical binding]; other site 693982014236 Molecular Tunnel; other site 693982014237 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982014238 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982014239 DNA-binding site [nucleotide binding]; DNA binding site 693982014240 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693982014241 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 693982014242 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982014243 Walker A/P-loop; other site 693982014244 ATP binding site [chemical binding]; other site 693982014245 Q-loop/lid; other site 693982014246 ABC transporter signature motif; other site 693982014247 Walker B; other site 693982014248 D-loop; other site 693982014249 H-loop/switch region; other site 693982014250 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982014251 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 693982014252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014253 dimer interface [polypeptide binding]; other site 693982014254 conserved gate region; other site 693982014255 putative PBP binding loops; other site 693982014256 ABC-ATPase subunit interface; other site 693982014257 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 693982014258 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982014259 Walker A/P-loop; other site 693982014260 ATP binding site [chemical binding]; other site 693982014261 Q-loop/lid; other site 693982014262 ABC transporter signature motif; other site 693982014263 Walker B; other site 693982014264 D-loop; other site 693982014265 H-loop/switch region; other site 693982014266 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982014267 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982014268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014269 dimer interface [polypeptide binding]; other site 693982014270 conserved gate region; other site 693982014271 putative PBP binding loops; other site 693982014272 ABC-ATPase subunit interface; other site 693982014273 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982014274 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 693982014275 peptide binding site [polypeptide binding]; other site 693982014276 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 693982014277 dimer interface [polypeptide binding]; other site 693982014278 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 693982014279 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 693982014280 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 693982014281 putative oligomer interface [polypeptide binding]; other site 693982014282 putative active site [active] 693982014283 metal binding site [ion binding]; metal-binding site 693982014284 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693982014285 nucleotide binding site [chemical binding]; other site 693982014286 Protein of unknown function (DUF995); Region: DUF995; pfam06191 693982014287 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 693982014288 Protein of unknown function (DUF995); Region: DUF995; pfam06191 693982014289 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 693982014290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693982014291 active site 693982014292 Cellulose synthase-like protein; Region: PLN02893 693982014293 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 693982014294 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 693982014295 NAD binding site [chemical binding]; other site 693982014296 homodimer interface [polypeptide binding]; other site 693982014297 active site 693982014298 substrate binding site [chemical binding]; other site 693982014299 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982014300 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 693982014301 NAD binding site [chemical binding]; other site 693982014302 putative substrate binding site 2 [chemical binding]; other site 693982014303 putative substrate binding site 1 [chemical binding]; other site 693982014304 active site 693982014305 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693982014306 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982014307 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693982014308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982014309 NAD(P) binding site [chemical binding]; other site 693982014310 active site 693982014311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982014312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982014313 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 693982014314 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 693982014315 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 693982014316 anti sigma factor interaction site; other site 693982014317 regulatory phosphorylation site [posttranslational modification]; other site 693982014318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 693982014319 Cache domain; Region: Cache_1; pfam02743 693982014320 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693982014321 dimerization interface [polypeptide binding]; other site 693982014322 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 693982014323 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 693982014324 Uncharacterized conserved protein [Function unknown]; Region: COG5439 693982014325 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 693982014326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982014327 S-adenosylmethionine binding site [chemical binding]; other site 693982014328 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693982014329 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982014330 metal binding site [ion binding]; metal-binding site 693982014331 active site 693982014332 I-site; other site 693982014333 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693982014334 mannonate dehydratase; Provisional; Region: PRK03906 693982014335 mannonate dehydratase; Region: uxuA; TIGR00695 693982014336 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 693982014337 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 693982014338 putative NAD(P) binding site [chemical binding]; other site 693982014339 catalytic Zn binding site [ion binding]; other site 693982014340 DctM-like transporters; Region: DctM; pfam06808 693982014341 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693982014342 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693982014343 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693982014344 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 693982014345 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982014346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982014347 DNA-binding site [nucleotide binding]; DNA binding site 693982014348 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 693982014349 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 693982014350 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 693982014351 putative active site [active] 693982014352 Zn binding site [ion binding]; other site 693982014353 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 693982014354 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 693982014355 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 693982014356 active site 693982014357 ectoine utilization protein EutC; Validated; Region: PRK08291 693982014358 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 693982014359 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 693982014360 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 693982014361 tetramer interface [polypeptide binding]; other site 693982014362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982014363 catalytic residue [active] 693982014364 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 693982014365 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693982014366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014367 dimer interface [polypeptide binding]; other site 693982014368 conserved gate region; other site 693982014369 putative PBP binding loops; other site 693982014370 ABC-ATPase subunit interface; other site 693982014371 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693982014372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014373 dimer interface [polypeptide binding]; other site 693982014374 conserved gate region; other site 693982014375 putative PBP binding loops; other site 693982014376 ABC-ATPase subunit interface; other site 693982014377 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 693982014378 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982014379 substrate binding pocket [chemical binding]; other site 693982014380 membrane-bound complex binding site; other site 693982014381 hinge residues; other site 693982014382 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 693982014383 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693982014384 Walker A/P-loop; other site 693982014385 ATP binding site [chemical binding]; other site 693982014386 Q-loop/lid; other site 693982014387 ABC transporter signature motif; other site 693982014388 Walker B; other site 693982014389 D-loop; other site 693982014390 H-loop/switch region; other site 693982014391 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693982014392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982014393 DNA-binding site [nucleotide binding]; DNA binding site 693982014394 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982014395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982014396 homodimer interface [polypeptide binding]; other site 693982014397 catalytic residue [active] 693982014398 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982014399 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982014400 putative DNA binding site [nucleotide binding]; other site 693982014401 putative Zn2+ binding site [ion binding]; other site 693982014402 AsnC family; Region: AsnC_trans_reg; pfam01037 693982014403 succinic semialdehyde dehydrogenase; Region: PLN02278 693982014404 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 693982014405 tetramerization interface [polypeptide binding]; other site 693982014406 NAD(P) binding site [chemical binding]; other site 693982014407 catalytic residues [active] 693982014408 hypothetical protein; Provisional; Region: PRK07482 693982014409 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693982014410 inhibitor-cofactor binding pocket; inhibition site 693982014411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982014412 catalytic residue [active] 693982014413 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982014414 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 693982014415 putative C-terminal domain interface [polypeptide binding]; other site 693982014416 putative GSH binding site (G-site) [chemical binding]; other site 693982014417 putative dimer interface [polypeptide binding]; other site 693982014418 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 693982014419 dimer interface [polypeptide binding]; other site 693982014420 N-terminal domain interface [polypeptide binding]; other site 693982014421 putative substrate binding pocket (H-site) [chemical binding]; other site 693982014422 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982014423 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982014424 Walker A/P-loop; other site 693982014425 ATP binding site [chemical binding]; other site 693982014426 Q-loop/lid; other site 693982014427 ABC transporter signature motif; other site 693982014428 Walker B; other site 693982014429 D-loop; other site 693982014430 H-loop/switch region; other site 693982014431 TOBE domain; Region: TOBE_2; pfam08402 693982014432 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982014433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014434 dimer interface [polypeptide binding]; other site 693982014435 conserved gate region; other site 693982014436 ABC-ATPase subunit interface; other site 693982014437 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 693982014438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014439 dimer interface [polypeptide binding]; other site 693982014440 conserved gate region; other site 693982014441 putative PBP binding loops; other site 693982014442 ABC-ATPase subunit interface; other site 693982014443 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693982014444 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982014445 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 693982014446 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982014447 putative NAD(P) binding site [chemical binding]; other site 693982014448 active site 693982014449 DoxX-like family; Region: DoxX_3; pfam13781 693982014450 Predicted integral membrane protein [Function unknown]; Region: COG5528 693982014451 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 693982014452 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 693982014453 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 693982014454 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 693982014455 classical (c) SDRs; Region: SDR_c; cd05233 693982014456 NAD(P) binding site [chemical binding]; other site 693982014457 active site 693982014458 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 693982014459 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 693982014460 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 693982014461 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 693982014462 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 693982014463 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 693982014464 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 693982014465 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982014466 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982014467 DNA binding residues [nucleotide binding] 693982014468 dimerization interface [polypeptide binding]; other site 693982014469 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693982014470 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982014471 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693982014472 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982014473 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982014474 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693982014475 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982014476 catalytic loop [active] 693982014477 iron binding site [ion binding]; other site 693982014478 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693982014479 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693982014480 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693982014481 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693982014482 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 693982014483 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 693982014484 putative active site [active] 693982014485 putative metal binding site [ion binding]; other site 693982014486 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693982014487 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982014488 catalytic loop [active] 693982014489 iron binding site [ion binding]; other site 693982014490 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693982014491 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 693982014492 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 693982014493 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693982014494 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693982014495 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982014496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 693982014497 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 693982014498 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 693982014499 dimer interface [polypeptide binding]; other site 693982014500 active site 693982014501 catalytic residue [active] 693982014502 metal binding site [ion binding]; metal-binding site 693982014503 transcriptional regulator NanR; Provisional; Region: PRK03837 693982014504 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982014505 DNA-binding site [nucleotide binding]; DNA binding site 693982014506 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 693982014507 FCD domain; Region: FCD; pfam07729 693982014508 Cellulose synthase-like protein; Region: PLN02893 693982014509 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 693982014510 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 693982014511 DXD motif; other site 693982014512 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 693982014513 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982014514 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693982014515 GAF domain; Region: GAF; pfam01590 693982014516 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693982014517 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693982014518 metal binding site [ion binding]; metal-binding site 693982014519 active site 693982014520 I-site; other site 693982014521 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 693982014522 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 693982014523 NAD(P) binding site [chemical binding]; other site 693982014524 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693982014525 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 693982014526 Bacterial transcriptional regulator; Region: IclR; pfam01614 693982014527 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 693982014528 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 693982014529 active site 693982014530 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 693982014531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693982014532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014533 dimer interface [polypeptide binding]; other site 693982014534 putative PBP binding loops; other site 693982014535 ABC-ATPase subunit interface; other site 693982014536 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982014537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014538 dimer interface [polypeptide binding]; other site 693982014539 conserved gate region; other site 693982014540 putative PBP binding loops; other site 693982014541 ABC-ATPase subunit interface; other site 693982014542 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693982014543 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 693982014544 Walker A/P-loop; other site 693982014545 ATP binding site [chemical binding]; other site 693982014546 Q-loop/lid; other site 693982014547 ABC transporter signature motif; other site 693982014548 Walker B; other site 693982014549 D-loop; other site 693982014550 H-loop/switch region; other site 693982014551 aminotransferase; Provisional; Region: PRK06105 693982014552 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693982014553 inhibitor-cofactor binding pocket; inhibition site 693982014554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982014555 catalytic residue [active] 693982014556 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693982014557 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 693982014558 tetramerization interface [polypeptide binding]; other site 693982014559 NAD(P) binding site [chemical binding]; other site 693982014560 catalytic residues [active] 693982014561 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693982014562 homotrimer interaction site [polypeptide binding]; other site 693982014563 putative active site [active] 693982014564 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693982014565 homotrimer interaction site [polypeptide binding]; other site 693982014566 putative active site [active] 693982014567 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982014568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982014569 DNA-binding site [nucleotide binding]; DNA binding site 693982014570 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693982014571 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693982014572 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 693982014573 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693982014574 DctM-like transporters; Region: DctM; pfam06808 693982014575 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693982014576 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 693982014577 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693982014578 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693982014579 Walker A/P-loop; other site 693982014580 ATP binding site [chemical binding]; other site 693982014581 Q-loop/lid; other site 693982014582 ABC transporter signature motif; other site 693982014583 Walker B; other site 693982014584 D-loop; other site 693982014585 H-loop/switch region; other site 693982014586 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 693982014587 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693982014588 FtsX-like permease family; Region: FtsX; pfam02687 693982014589 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693982014590 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982014591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982014592 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982014593 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982014594 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982014595 DNA binding site [nucleotide binding] 693982014596 domain linker motif; other site 693982014597 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 693982014598 putative dimerization interface [polypeptide binding]; other site 693982014599 putative ligand binding site [chemical binding]; other site 693982014600 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 693982014601 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 693982014602 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 693982014603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014604 dimer interface [polypeptide binding]; other site 693982014605 conserved gate region; other site 693982014606 putative PBP binding loops; other site 693982014607 ABC-ATPase subunit interface; other site 693982014608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014609 dimer interface [polypeptide binding]; other site 693982014610 conserved gate region; other site 693982014611 putative PBP binding loops; other site 693982014612 ABC-ATPase subunit interface; other site 693982014613 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693982014614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982014615 Walker A/P-loop; other site 693982014616 ATP binding site [chemical binding]; other site 693982014617 Q-loop/lid; other site 693982014618 ABC transporter signature motif; other site 693982014619 Walker B; other site 693982014620 D-loop; other site 693982014621 H-loop/switch region; other site 693982014622 TOBE domain; Region: TOBE_2; pfam08402 693982014623 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693982014624 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 693982014625 active site 693982014626 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 693982014627 Ion channel; Region: Ion_trans_2; pfam07885 693982014628 Predicted periplasmic protein [Function unknown]; Region: COG3904 693982014629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982014630 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982014631 phosphorylation site [posttranslational modification] 693982014632 dimer interface [polypeptide binding]; other site 693982014633 Response regulator receiver domain; Region: Response_reg; pfam00072 693982014634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982014635 active site 693982014636 phosphorylation site [posttranslational modification] 693982014637 intermolecular recognition site; other site 693982014638 dimerization interface [polypeptide binding]; other site 693982014639 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 693982014640 cyclase homology domain; Region: CHD; cd07302 693982014641 nucleotidyl binding site; other site 693982014642 metal binding site [ion binding]; metal-binding site 693982014643 dimer interface [polypeptide binding]; other site 693982014644 Response regulator receiver domain; Region: Response_reg; pfam00072 693982014645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982014646 active site 693982014647 phosphorylation site [posttranslational modification] 693982014648 intermolecular recognition site; other site 693982014649 dimerization interface [polypeptide binding]; other site 693982014650 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693982014651 dimerization interface [polypeptide binding]; other site 693982014652 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 693982014653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982014654 dimer interface [polypeptide binding]; other site 693982014655 phosphorylation site [posttranslational modification] 693982014656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982014657 ATP binding site [chemical binding]; other site 693982014658 Mg2+ binding site [ion binding]; other site 693982014659 G-X-G motif; other site 693982014660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982014661 Response regulator receiver domain; Region: Response_reg; pfam00072 693982014662 active site 693982014663 phosphorylation site [posttranslational modification] 693982014664 intermolecular recognition site; other site 693982014665 dimerization interface [polypeptide binding]; other site 693982014666 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693982014667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982014668 active site 693982014669 phosphorylation site [posttranslational modification] 693982014670 intermolecular recognition site; other site 693982014671 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 693982014672 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982014673 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982014674 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982014675 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982014676 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982014677 TM-ABC transporter signature motif; other site 693982014678 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982014679 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982014680 Walker A/P-loop; other site 693982014681 ATP binding site [chemical binding]; other site 693982014682 Q-loop/lid; other site 693982014683 ABC transporter signature motif; other site 693982014684 Walker B; other site 693982014685 D-loop; other site 693982014686 H-loop/switch region; other site 693982014687 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982014688 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5618 693982014689 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 693982014690 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693982014691 ligand binding site [chemical binding]; other site 693982014692 dimerization interface [polypeptide binding]; other site 693982014693 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 693982014694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982014695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982014696 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693982014697 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982014698 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982014699 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693982014700 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 693982014701 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693982014702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982014703 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693982014704 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982014705 catalytic loop [active] 693982014706 iron binding site [ion binding]; other site 693982014707 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693982014708 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693982014709 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693982014710 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982014711 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982014712 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693982014713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982014714 putative substrate translocation pore; other site 693982014715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982014716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982014717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 693982014718 Autotransporter beta-domain; Region: Autotransporter; smart00869 693982014719 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 693982014720 Uncharacterized conserved protein [Function unknown]; Region: COG1262 693982014721 SPW repeat; Region: SPW; pfam03779 693982014722 SPW repeat; Region: SPW; pfam03779 693982014723 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982014724 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982014725 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982014726 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 693982014727 conserved cys residue [active] 693982014728 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982014729 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982014730 Walker A/P-loop; other site 693982014731 ATP binding site [chemical binding]; other site 693982014732 Q-loop/lid; other site 693982014733 ABC transporter signature motif; other site 693982014734 Walker B; other site 693982014735 D-loop; other site 693982014736 H-loop/switch region; other site 693982014737 TOBE domain; Region: TOBE_2; pfam08402 693982014738 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982014739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014740 dimer interface [polypeptide binding]; other site 693982014741 conserved gate region; other site 693982014742 putative PBP binding loops; other site 693982014743 ABC-ATPase subunit interface; other site 693982014744 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982014745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014746 dimer interface [polypeptide binding]; other site 693982014747 conserved gate region; other site 693982014748 putative PBP binding loops; other site 693982014749 ABC-ATPase subunit interface; other site 693982014750 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982014751 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 693982014752 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982014753 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982014754 DNA binding site [nucleotide binding] 693982014755 domain linker motif; other site 693982014756 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 693982014757 ligand binding site [chemical binding]; other site 693982014758 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982014759 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982014760 DNA-binding site [nucleotide binding]; DNA binding site 693982014761 FCD domain; Region: FCD; pfam07729 693982014762 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693982014763 DctM-like transporters; Region: DctM; pfam06808 693982014764 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693982014765 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693982014766 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 693982014767 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 693982014768 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982014769 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982014770 TM-ABC transporter signature motif; other site 693982014771 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982014772 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982014773 Walker A/P-loop; other site 693982014774 ATP binding site [chemical binding]; other site 693982014775 Q-loop/lid; other site 693982014776 ABC transporter signature motif; other site 693982014777 Walker B; other site 693982014778 D-loop; other site 693982014779 H-loop/switch region; other site 693982014780 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982014781 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 693982014782 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693982014783 ligand binding site [chemical binding]; other site 693982014784 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982014785 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982014786 TM-ABC transporter signature motif; other site 693982014787 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 693982014788 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 693982014789 DAK2 domain; Region: Dak2; pfam02734 693982014790 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 693982014791 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982014792 DNA binding residues [nucleotide binding] 693982014793 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 693982014794 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 693982014795 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 693982014796 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 693982014797 DAK2 domain; Region: Dak2; cl03685 693982014798 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 693982014799 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 693982014800 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982014801 cyclase homology domain; Region: CHD; cd07302 693982014802 nucleotidyl binding site; other site 693982014803 metal binding site [ion binding]; metal-binding site 693982014804 dimer interface [polypeptide binding]; other site 693982014805 Predicted integral membrane protein [Function unknown]; Region: COG5616 693982014806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693982014807 binding surface 693982014808 TPR motif; other site 693982014809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982014810 TPR motif; other site 693982014811 Tetratricopeptide repeat; Region: TPR_16; pfam13432 693982014812 binding surface 693982014813 N-acetylneuraminate lyase; Provisional; Region: PRK04147 693982014814 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 693982014815 inhibitor site; inhibition site 693982014816 active site 693982014817 dimer interface [polypeptide binding]; other site 693982014818 catalytic residue [active] 693982014819 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 693982014820 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 693982014821 inhibitor site; inhibition site 693982014822 active site 693982014823 dimer interface [polypeptide binding]; other site 693982014824 catalytic residue [active] 693982014825 DctM-like transporters; Region: DctM; pfam06808 693982014826 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693982014827 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693982014828 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693982014829 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 693982014830 transcriptional regulator NanR; Provisional; Region: PRK03837 693982014831 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982014832 DNA-binding site [nucleotide binding]; DNA binding site 693982014833 FCD domain; Region: FCD; pfam07729 693982014834 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 693982014835 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 693982014836 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 693982014837 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 693982014838 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 693982014839 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982014840 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982014841 DNA binding site [nucleotide binding] 693982014842 domain linker motif; other site 693982014843 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 693982014844 putative dimerization interface [polypeptide binding]; other site 693982014845 putative ligand binding site [chemical binding]; other site 693982014846 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 693982014847 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693982014848 active site 693982014849 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693982014850 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 693982014851 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982014852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982014853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982014854 dimerization interface [polypeptide binding]; other site 693982014855 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 693982014856 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 693982014857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693982014858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014859 ABC-ATPase subunit interface; other site 693982014860 putative PBP binding loops; other site 693982014861 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982014862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014863 dimer interface [polypeptide binding]; other site 693982014864 conserved gate region; other site 693982014865 putative PBP binding loops; other site 693982014866 ABC-ATPase subunit interface; other site 693982014867 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693982014868 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 693982014869 Walker A/P-loop; other site 693982014870 ATP binding site [chemical binding]; other site 693982014871 Q-loop/lid; other site 693982014872 ABC transporter signature motif; other site 693982014873 Walker B; other site 693982014874 D-loop; other site 693982014875 H-loop/switch region; other site 693982014876 TOBE domain; Region: TOBE_2; pfam08402 693982014877 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 693982014878 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 693982014879 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693982014880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 693982014881 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 693982014882 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 693982014883 hypothetical protein; Provisional; Region: PRK07483 693982014884 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693982014885 inhibitor-cofactor binding pocket; inhibition site 693982014886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982014887 catalytic residue [active] 693982014888 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693982014889 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693982014890 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693982014891 putative active site [active] 693982014892 Uncharacterized conserved protein [Function unknown]; Region: COG3246 693982014893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982014894 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693982014895 putative substrate translocation pore; other site 693982014896 OsmC-like protein; Region: OsmC; cl00767 693982014897 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 693982014898 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 693982014899 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 693982014900 substrate binding site [chemical binding]; other site 693982014901 Protein of unknown function (DUF521); Region: DUF521; pfam04412 693982014902 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 693982014903 substrate binding site [chemical binding]; other site 693982014904 ligand binding site [chemical binding]; other site 693982014905 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 693982014906 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 693982014907 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 693982014908 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 693982014909 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693982014910 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693982014911 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693982014912 Walker A/P-loop; other site 693982014913 ATP binding site [chemical binding]; other site 693982014914 Q-loop/lid; other site 693982014915 ABC transporter signature motif; other site 693982014916 Walker B; other site 693982014917 D-loop; other site 693982014918 H-loop/switch region; other site 693982014919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014920 dimer interface [polypeptide binding]; other site 693982014921 conserved gate region; other site 693982014922 putative PBP binding loops; other site 693982014923 ABC-ATPase subunit interface; other site 693982014924 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693982014925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982014926 dimer interface [polypeptide binding]; other site 693982014927 conserved gate region; other site 693982014928 putative PBP binding loops; other site 693982014929 ABC-ATPase subunit interface; other site 693982014930 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693982014931 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982014932 substrate binding pocket [chemical binding]; other site 693982014933 membrane-bound complex binding site; other site 693982014934 hinge residues; other site 693982014935 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 693982014936 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 693982014937 dimer interface [polypeptide binding]; other site 693982014938 NADP binding site [chemical binding]; other site 693982014939 catalytic residues [active] 693982014940 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 693982014941 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 693982014942 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 693982014943 inhibitor site; inhibition site 693982014944 active site 693982014945 dimer interface [polypeptide binding]; other site 693982014946 catalytic residue [active] 693982014947 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982014948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982014949 DNA-binding site [nucleotide binding]; DNA binding site 693982014950 FCD domain; Region: FCD; pfam07729 693982014951 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982014952 cyclase homology domain; Region: CHD; cd07302 693982014953 nucleotidyl binding site; other site 693982014954 metal binding site [ion binding]; metal-binding site 693982014955 dimer interface [polypeptide binding]; other site 693982014956 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 693982014957 putative hydrophobic ligand binding site [chemical binding]; other site 693982014958 Predicted membrane protein [Function unknown]; Region: COG4420 693982014959 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 693982014960 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 693982014961 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 693982014962 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 693982014963 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 693982014964 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693982014965 catalytic core [active] 693982014966 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 693982014967 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 693982014968 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982014969 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982014970 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982014971 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693982014972 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 693982014973 putative NAD(P) binding site [chemical binding]; other site 693982014974 catalytic Zn binding site [ion binding]; other site 693982014975 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982014976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982014977 NAD(P) binding site [chemical binding]; other site 693982014978 active site 693982014979 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 693982014980 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982014981 NAD binding site [chemical binding]; other site 693982014982 homotetramer interface [polypeptide binding]; other site 693982014983 homodimer interface [polypeptide binding]; other site 693982014984 active site 693982014985 substrate binding site [chemical binding]; other site 693982014986 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693982014987 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982014988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 693982014989 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 693982014990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 693982014991 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 693982014992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 693982014993 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 693982014994 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 693982014995 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982014996 NAD binding site [chemical binding]; other site 693982014997 putative substrate binding site 2 [chemical binding]; other site 693982014998 putative substrate binding site 1 [chemical binding]; other site 693982014999 active site 693982015000 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693982015001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982015002 S-adenosylmethionine binding site [chemical binding]; other site 693982015003 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982015004 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982015005 Walker A/P-loop; other site 693982015006 ATP binding site [chemical binding]; other site 693982015007 Q-loop/lid; other site 693982015008 ABC transporter signature motif; other site 693982015009 Walker B; other site 693982015010 D-loop; other site 693982015011 H-loop/switch region; other site 693982015012 TOBE domain; Region: TOBE_2; pfam08402 693982015013 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 693982015014 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982015015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982015016 dimer interface [polypeptide binding]; other site 693982015017 conserved gate region; other site 693982015018 putative PBP binding loops; other site 693982015019 ABC-ATPase subunit interface; other site 693982015020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693982015021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982015022 ABC-ATPase subunit interface; other site 693982015023 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982015024 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982015025 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982015026 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982015027 DNA binding site [nucleotide binding] 693982015028 domain linker motif; other site 693982015029 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693982015030 dimerization interface [polypeptide binding]; other site 693982015031 ligand binding site [chemical binding]; other site 693982015032 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 693982015033 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 693982015034 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 693982015035 BON domain; Region: BON; pfam04972 693982015036 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 693982015037 Cupin domain; Region: Cupin_2; pfam07883 693982015038 Epoxide hydrolase N terminus; Region: EHN; pfam06441 693982015039 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693982015040 osmolarity response regulator; Provisional; Region: ompR; PRK09468 693982015041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982015042 active site 693982015043 phosphorylation site [posttranslational modification] 693982015044 intermolecular recognition site; other site 693982015045 dimerization interface [polypeptide binding]; other site 693982015046 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982015047 DNA binding site [nucleotide binding] 693982015048 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 693982015049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 693982015050 dimer interface [polypeptide binding]; other site 693982015051 phosphorylation site [posttranslational modification] 693982015052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982015053 ATP binding site [chemical binding]; other site 693982015054 Mg2+ binding site [ion binding]; other site 693982015055 G-X-G motif; other site 693982015056 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 693982015057 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982015058 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693982015059 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 693982015060 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 693982015061 conserved cys residue [active] 693982015062 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982015063 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 693982015064 classical (c) SDRs; Region: SDR_c; cd05233 693982015065 NAD(P) binding site [chemical binding]; other site 693982015066 active site 693982015067 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 693982015068 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 693982015069 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 693982015070 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693982015071 catalytic residues [active] 693982015072 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 693982015073 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 693982015074 potential catalytic triad [active] 693982015075 conserved cys residue [active] 693982015076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982015077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982015078 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 693982015079 putative effector binding pocket; other site 693982015080 putative dimerization interface [polypeptide binding]; other site 693982015081 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693982015082 classical (c) SDRs; Region: SDR_c; cd05233 693982015083 NAD(P) binding site [chemical binding]; other site 693982015084 active site 693982015085 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 693982015086 active site 1 [active] 693982015087 dimer interface [polypeptide binding]; other site 693982015088 hexamer interface [polypeptide binding]; other site 693982015089 active site 2 [active] 693982015090 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 693982015091 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693982015092 FeS/SAM binding site; other site 693982015093 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 693982015094 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 693982015095 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 693982015096 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 693982015097 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 693982015098 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 693982015099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982015100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982015101 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 693982015102 putative dimerization interface [polypeptide binding]; other site 693982015103 fructose-1,6-bisphosphatase family protein; Region: PLN02628 693982015104 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 693982015105 AMP binding site [chemical binding]; other site 693982015106 metal binding site [ion binding]; metal-binding site 693982015107 active site 693982015108 phosphoribulokinase; Provisional; Region: PRK15453 693982015109 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 693982015110 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 693982015111 TPP-binding site [chemical binding]; other site 693982015112 dimer interface [polypeptide binding]; other site 693982015113 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693982015114 PYR/PP interface [polypeptide binding]; other site 693982015115 dimer interface [polypeptide binding]; other site 693982015116 TPP binding site [chemical binding]; other site 693982015117 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693982015118 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 693982015119 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 693982015120 intersubunit interface [polypeptide binding]; other site 693982015121 active site 693982015122 zinc binding site [ion binding]; other site 693982015123 Na+ binding site [ion binding]; other site 693982015124 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 693982015125 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 693982015126 homodimer interface [polypeptide binding]; other site 693982015127 active site 693982015128 heterodimer interface [polypeptide binding]; other site 693982015129 catalytic residue [active] 693982015130 metal binding site [ion binding]; metal-binding site 693982015131 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 693982015132 multimerization interface [polypeptide binding]; other site 693982015133 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 693982015134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982015135 Walker A motif; other site 693982015136 ATP binding site [chemical binding]; other site 693982015137 Walker B motif; other site 693982015138 arginine finger; other site 693982015139 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 693982015140 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 693982015141 substrate binding site [chemical binding]; other site 693982015142 hexamer interface [polypeptide binding]; other site 693982015143 metal binding site [ion binding]; metal-binding site 693982015144 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 693982015145 putative catalytic residue [active] 693982015146 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 693982015147 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693982015148 alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861 693982015149 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 693982015150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982015151 Walker A/P-loop; other site 693982015152 ATP binding site [chemical binding]; other site 693982015153 Q-loop/lid; other site 693982015154 ABC transporter signature motif; other site 693982015155 Walker B; other site 693982015156 D-loop; other site 693982015157 H-loop/switch region; other site 693982015158 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 693982015159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982015160 Walker A/P-loop; other site 693982015161 ATP binding site [chemical binding]; other site 693982015162 Q-loop/lid; other site 693982015163 ABC transporter signature motif; other site 693982015164 Walker B; other site 693982015165 D-loop; other site 693982015166 H-loop/switch region; other site 693982015167 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693982015168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982015169 dimer interface [polypeptide binding]; other site 693982015170 conserved gate region; other site 693982015171 putative PBP binding loops; other site 693982015172 ABC-ATPase subunit interface; other site 693982015173 NMT1/THI5 like; Region: NMT1; pfam09084 693982015174 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 693982015175 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 693982015176 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 693982015177 structural tetrad; other site 693982015178 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 693982015179 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 693982015180 ligand binding site [chemical binding]; other site 693982015181 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 693982015182 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693982015183 active site residue [active] 693982015184 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 693982015185 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982015186 substrate binding pocket [chemical binding]; other site 693982015187 membrane-bound complex binding site; other site 693982015188 hinge residues; other site 693982015189 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693982015190 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 693982015191 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 693982015192 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 693982015193 Trp docking motif [polypeptide binding]; other site 693982015194 dimer interface [polypeptide binding]; other site 693982015195 active site 693982015196 small subunit binding site [polypeptide binding]; other site 693982015197 Cytochrome c2 [Energy production and conversion]; Region: COG3474 693982015198 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 693982015199 S-formylglutathione hydrolase; Region: PLN02442 693982015200 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 693982015201 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 693982015202 substrate binding site [chemical binding]; other site 693982015203 catalytic Zn binding site [ion binding]; other site 693982015204 NAD binding site [chemical binding]; other site 693982015205 structural Zn binding site [ion binding]; other site 693982015206 dimer interface [polypeptide binding]; other site 693982015207 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693982015208 Predicted secreted protein [Function unknown]; Region: COG5501 693982015209 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 693982015210 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 693982015211 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 693982015212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982015213 dimer interface [polypeptide binding]; other site 693982015214 phosphorylation site [posttranslational modification] 693982015215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982015216 ATP binding site [chemical binding]; other site 693982015217 Mg2+ binding site [ion binding]; other site 693982015218 G-X-G motif; other site 693982015219 Response regulator receiver domain; Region: Response_reg; pfam00072 693982015220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982015221 active site 693982015222 phosphorylation site [posttranslational modification] 693982015223 intermolecular recognition site; other site 693982015224 dimerization interface [polypeptide binding]; other site 693982015225 Uncharacterized conserved protein [Function unknown]; Region: COG3287 693982015226 FIST N domain; Region: FIST; pfam08495 693982015227 FIST C domain; Region: FIST_C; pfam10442 693982015228 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982015229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982015230 active site 693982015231 phosphorylation site [posttranslational modification] 693982015232 intermolecular recognition site; other site 693982015233 dimerization interface [polypeptide binding]; other site 693982015234 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982015235 DNA binding residues [nucleotide binding] 693982015236 dimerization interface [polypeptide binding]; other site 693982015237 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693982015238 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693982015239 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 693982015240 active site 693982015241 catalytic residues [active] 693982015242 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693982015243 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 693982015244 active site 693982015245 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693982015246 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 693982015247 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 693982015248 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693982015249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982015250 Walker A/P-loop; other site 693982015251 ATP binding site [chemical binding]; other site 693982015252 Q-loop/lid; other site 693982015253 ABC transporter signature motif; other site 693982015254 Walker B; other site 693982015255 D-loop; other site 693982015256 H-loop/switch region; other site 693982015257 TOBE domain; Region: TOBE_2; pfam08402 693982015258 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 693982015259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982015260 dimer interface [polypeptide binding]; other site 693982015261 conserved gate region; other site 693982015262 putative PBP binding loops; other site 693982015263 ABC-ATPase subunit interface; other site 693982015264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982015265 dimer interface [polypeptide binding]; other site 693982015266 conserved gate region; other site 693982015267 putative PBP binding loops; other site 693982015268 ABC-ATPase subunit interface; other site 693982015269 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982015270 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982015271 DNA binding site [nucleotide binding] 693982015272 domain linker motif; other site 693982015273 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 693982015274 putative dimerization interface [polypeptide binding]; other site 693982015275 putative ligand binding site [chemical binding]; other site 693982015276 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 693982015277 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 693982015278 PhoU domain; Region: PhoU; pfam01895 693982015279 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 693982015280 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 693982015281 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 693982015282 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 693982015283 active site 693982015284 catalytic residues [active] 693982015285 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693982015286 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 693982015287 active site 693982015288 dimerization interface [polypeptide binding]; other site 693982015289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 693982015290 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982015291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982015292 DNA-binding site [nucleotide binding]; DNA binding site 693982015293 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693982015294 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 693982015295 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 693982015296 putative active site [active] 693982015297 metal binding site [ion binding]; metal-binding site 693982015298 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 693982015299 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 693982015300 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 693982015301 BNR repeat-like domain; Region: BNR_2; pfam13088 693982015302 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982015303 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 693982015304 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982015305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982015306 dimer interface [polypeptide binding]; other site 693982015307 conserved gate region; other site 693982015308 putative PBP binding loops; other site 693982015309 ABC-ATPase subunit interface; other site 693982015310 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982015311 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 693982015312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982015313 dimer interface [polypeptide binding]; other site 693982015314 conserved gate region; other site 693982015315 putative PBP binding loops; other site 693982015316 ABC-ATPase subunit interface; other site 693982015317 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 693982015318 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982015319 Walker A/P-loop; other site 693982015320 ATP binding site [chemical binding]; other site 693982015321 Q-loop/lid; other site 693982015322 ABC transporter signature motif; other site 693982015323 Walker B; other site 693982015324 D-loop; other site 693982015325 H-loop/switch region; other site 693982015326 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982015327 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982015328 Walker A/P-loop; other site 693982015329 ATP binding site [chemical binding]; other site 693982015330 Q-loop/lid; other site 693982015331 ABC transporter signature motif; other site 693982015332 Walker B; other site 693982015333 D-loop; other site 693982015334 H-loop/switch region; other site 693982015335 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982015336 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 693982015337 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 693982015338 inhibitor site; inhibition site 693982015339 active site 693982015340 dimer interface [polypeptide binding]; other site 693982015341 catalytic residue [active] 693982015342 Predicted membrane protein [Function unknown]; Region: COG4329 693982015343 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 693982015344 active site 693982015345 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 693982015346 active site 693982015347 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 693982015348 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 693982015349 Flavoprotein; Region: Flavoprotein; pfam02441 693982015350 xanthine permease; Region: pbuX; TIGR03173 693982015351 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 693982015352 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 693982015353 P-loop, Walker A motif; other site 693982015354 Base recognition motif; other site 693982015355 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 693982015356 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693982015357 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693982015358 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982015359 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693982015360 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982015361 catalytic loop [active] 693982015362 iron binding site [ion binding]; other site 693982015363 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693982015364 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 693982015365 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 693982015366 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982015367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 693982015368 DNA-binding site [nucleotide binding]; DNA binding site 693982015369 FCD domain; Region: FCD; pfam07729 693982015370 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 693982015371 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 693982015372 putative ligand binding site [chemical binding]; other site 693982015373 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982015374 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693982015375 TM-ABC transporter signature motif; other site 693982015376 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982015377 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693982015378 TM-ABC transporter signature motif; other site 693982015379 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 693982015380 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982015381 Walker A/P-loop; other site 693982015382 ATP binding site [chemical binding]; other site 693982015383 Q-loop/lid; other site 693982015384 ABC transporter signature motif; other site 693982015385 Walker B; other site 693982015386 D-loop; other site 693982015387 H-loop/switch region; other site 693982015388 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982015389 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982015390 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982015391 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 693982015392 putative dimerization interface [polypeptide binding]; other site 693982015393 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 693982015394 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 693982015395 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693982015396 homotrimer interaction site [polypeptide binding]; other site 693982015397 putative active site [active] 693982015398 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 693982015399 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982015400 putative ADP-binding pocket [chemical binding]; other site 693982015401 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 693982015402 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 693982015403 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 693982015404 hypothetical protein; Validated; Region: PRK08245 693982015405 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693982015406 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 693982015407 putative ligand binding site [chemical binding]; other site 693982015408 NAD binding site [chemical binding]; other site 693982015409 catalytic site [active] 693982015410 EamA-like transporter family; Region: EamA; pfam00892 693982015411 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693982015412 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 693982015413 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982015414 Walker A/P-loop; other site 693982015415 ATP binding site [chemical binding]; other site 693982015416 Q-loop/lid; other site 693982015417 ABC transporter signature motif; other site 693982015418 Walker B; other site 693982015419 D-loop; other site 693982015420 H-loop/switch region; other site 693982015421 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982015422 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982015423 Walker A/P-loop; other site 693982015424 ATP binding site [chemical binding]; other site 693982015425 Q-loop/lid; other site 693982015426 ABC transporter signature motif; other site 693982015427 Walker B; other site 693982015428 D-loop; other site 693982015429 H-loop/switch region; other site 693982015430 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982015431 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982015432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982015433 dimer interface [polypeptide binding]; other site 693982015434 conserved gate region; other site 693982015435 putative PBP binding loops; other site 693982015436 ABC-ATPase subunit interface; other site 693982015437 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982015438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982015439 dimer interface [polypeptide binding]; other site 693982015440 conserved gate region; other site 693982015441 putative PBP binding loops; other site 693982015442 ABC-ATPase subunit interface; other site 693982015443 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982015444 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 693982015445 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 693982015446 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 693982015447 inhibitor site; inhibition site 693982015448 active site 693982015449 dimer interface [polypeptide binding]; other site 693982015450 catalytic residue [active] 693982015451 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982015452 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982015453 DNA-binding site [nucleotide binding]; DNA binding site 693982015454 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693982015455 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982015456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982015457 DNA-binding site [nucleotide binding]; DNA binding site 693982015458 FCD domain; Region: FCD; pfam07729 693982015459 SnoaL-like domain; Region: SnoaL_2; pfam12680 693982015460 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 693982015461 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 693982015462 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 693982015463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982015464 Walker A motif; other site 693982015465 ATP binding site [chemical binding]; other site 693982015466 Walker B motif; other site 693982015467 arginine finger; other site 693982015468 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693982015469 Predicted dehydrogenase [General function prediction only]; Region: COG0579 693982015470 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693982015471 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 693982015472 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 693982015473 trehalose synthase; Region: treS_nterm; TIGR02456 693982015474 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 693982015475 active site 693982015476 catalytic site [active] 693982015477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4288 693982015478 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 693982015479 FAD binding domain; Region: FAD_binding_4; pfam01565 693982015480 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 693982015481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4288 693982015482 thiamine pyrophosphate protein; Provisional; Region: PRK08273 693982015483 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 693982015484 PYR/PP interface [polypeptide binding]; other site 693982015485 dimer interface [polypeptide binding]; other site 693982015486 tetramer interface [polypeptide binding]; other site 693982015487 TPP binding site [chemical binding]; other site 693982015488 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693982015489 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 693982015490 TPP-binding site [chemical binding]; other site 693982015491 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 693982015492 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 693982015493 putative active site [active] 693982015494 catalytic site [active] 693982015495 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 693982015496 putative active site [active] 693982015497 catalytic site [active] 693982015498 Predicted integral membrane protein [Function unknown]; Region: COG0392 693982015499 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 693982015500 putative catalytic site [active] 693982015501 putative metal binding site [ion binding]; other site 693982015502 putative phosphate binding site [ion binding]; other site 693982015503 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 693982015504 dinuclear metal binding motif [ion binding]; other site 693982015505 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 693982015506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982015507 S-adenosylmethionine binding site [chemical binding]; other site 693982015508 Erythromycin esterase; Region: Erythro_esteras; pfam05139 693982015509 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 693982015510 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 693982015511 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693982015512 active site 693982015513 metal binding site [ion binding]; metal-binding site 693982015514 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 693982015515 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693982015516 NAD binding site [chemical binding]; other site 693982015517 catalytic Zn binding site [ion binding]; other site 693982015518 structural Zn binding site [ion binding]; other site 693982015519 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 693982015520 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 693982015521 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 693982015522 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 693982015523 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 693982015524 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982015525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982015526 active site 693982015527 phosphorylation site [posttranslational modification] 693982015528 intermolecular recognition site; other site 693982015529 dimerization interface [polypeptide binding]; other site 693982015530 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982015531 DNA binding residues [nucleotide binding] 693982015532 dimerization interface [polypeptide binding]; other site 693982015533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 693982015534 Histidine kinase; Region: HisKA_3; pfam07730 693982015535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982015536 ATP binding site [chemical binding]; other site 693982015537 Mg2+ binding site [ion binding]; other site 693982015538 G-X-G motif; other site 693982015539 short chain dehydrogenase; Provisional; Region: PRK06139 693982015540 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 693982015541 putative NAD(P) binding site [chemical binding]; other site 693982015542 active site 693982015543 short chain dehydrogenase; Provisional; Region: PRK06701 693982015544 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 693982015545 NAD binding site [chemical binding]; other site 693982015546 metal binding site [ion binding]; metal-binding site 693982015547 active site 693982015548 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982015549 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 693982015550 putative ligand binding site [chemical binding]; other site 693982015551 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693982015552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982015553 putative substrate translocation pore; other site 693982015554 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 693982015555 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693982015556 Sulfate transporter family; Region: Sulfate_transp; pfam00916 693982015557 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 693982015558 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693982015559 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 693982015560 Uncharacterized conserved protein [Function unknown]; Region: COG3360 693982015561 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 693982015562 trimer interface [polypeptide binding]; other site 693982015563 putative Zn binding site [ion binding]; other site 693982015564 Transposase; Region: HTH_Tnp_1; cl17663 693982015565 Winged helix-turn helix; Region: HTH_29; pfam13551 693982015566 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 693982015567 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 693982015568 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 693982015569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982015570 S-adenosylmethionine binding site [chemical binding]; other site 693982015571 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 693982015572 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693982015573 Walker A/P-loop; other site 693982015574 ATP binding site [chemical binding]; other site 693982015575 Q-loop/lid; other site 693982015576 ABC transporter signature motif; other site 693982015577 Walker B; other site 693982015578 D-loop; other site 693982015579 H-loop/switch region; other site 693982015580 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693982015581 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693982015582 ABC-ATPase subunit interface; other site 693982015583 dimer interface [polypeptide binding]; other site 693982015584 putative PBP binding regions; other site 693982015585 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 693982015586 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 693982015587 putative ligand binding residues [chemical binding]; other site 693982015588 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 693982015589 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 693982015590 DctM-like transporters; Region: DctM; pfam06808 693982015591 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 693982015592 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 693982015593 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 693982015594 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 693982015595 conserved cys residue [active] 693982015596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982015597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982015598 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693982015599 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693982015600 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693982015601 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 693982015602 elongation factor G; Reviewed; Region: PRK12740 693982015603 G1 box; other site 693982015604 GTP/Mg2+ binding site [chemical binding]; other site 693982015605 G2 box; other site 693982015606 G3 box; other site 693982015607 Switch II region; other site 693982015608 G4 box; other site 693982015609 G5 box; other site 693982015610 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 693982015611 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 693982015612 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 693982015613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982015614 DNA-binding site [nucleotide binding]; DNA binding site 693982015615 UTRA domain; Region: UTRA; pfam07702 693982015616 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 693982015617 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693982015618 P-loop; other site 693982015619 Magnesium ion binding site [ion binding]; other site 693982015620 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693982015621 Magnesium ion binding site [ion binding]; other site 693982015622 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 693982015623 ParB-like nuclease domain; Region: ParB; smart00470 693982015624 replication initiation protein RepC; Provisional; Region: PRK13824 693982015625 Replication protein C N-terminal domain; Region: RP-C; pfam03428 693982015626 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 693982015627 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 693982015628 HTH DNA binding domain; Region: HTH_13; pfam11972 693982015629 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693982015630 EamA-like transporter family; Region: EamA; pfam00892 693982015631 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693982015632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982015633 DNA-binding site [nucleotide binding]; DNA binding site 693982015634 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982015635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982015636 homodimer interface [polypeptide binding]; other site 693982015637 catalytic residue [active] 693982015638 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693982015639 catalytic residues [active] 693982015640 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 693982015641 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 693982015642 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 693982015643 shikimate binding site; other site 693982015644 NAD(P) binding site [chemical binding]; other site 693982015645 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693982015646 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 693982015647 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 693982015648 DctM-like transporters; Region: DctM; pfam06808 693982015649 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693982015650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982015651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982015652 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 693982015653 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982015654 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 693982015655 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 693982015656 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 693982015657 Uncharacterized conserved protein [Function unknown]; Region: COG2128 693982015658 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 693982015659 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 693982015660 active site 693982015661 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 693982015662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 693982015663 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 693982015664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 693982015665 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 693982015666 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693982015667 RNA binding surface [nucleotide binding]; other site 693982015668 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 693982015669 active site 693982015670 5-oxoprolinase; Region: PLN02666 693982015671 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 693982015672 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 693982015673 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 693982015674 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 693982015675 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982015676 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982015677 putative DNA binding site [nucleotide binding]; other site 693982015678 putative Zn2+ binding site [ion binding]; other site 693982015679 AsnC family; Region: AsnC_trans_reg; pfam01037 693982015680 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 693982015681 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 693982015682 tetramer interface [polypeptide binding]; other site 693982015683 TPP-binding site [chemical binding]; other site 693982015684 heterodimer interface [polypeptide binding]; other site 693982015685 phosphorylation loop region [posttranslational modification] 693982015686 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 693982015687 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 693982015688 alpha subunit interface [polypeptide binding]; other site 693982015689 TPP binding site [chemical binding]; other site 693982015690 heterodimer interface [polypeptide binding]; other site 693982015691 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693982015692 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 693982015693 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693982015694 E3 interaction surface; other site 693982015695 lipoyl attachment site [posttranslational modification]; other site 693982015696 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693982015697 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 693982015698 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693982015699 putative ligand binding site [chemical binding]; other site 693982015700 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982015701 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693982015702 Walker A/P-loop; other site 693982015703 ATP binding site [chemical binding]; other site 693982015704 Q-loop/lid; other site 693982015705 ABC transporter signature motif; other site 693982015706 Walker B; other site 693982015707 D-loop; other site 693982015708 H-loop/switch region; other site 693982015709 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982015710 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982015711 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982015712 TM-ABC transporter signature motif; other site 693982015713 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982015714 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982015715 TM-ABC transporter signature motif; other site 693982015716 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982015717 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982015718 DNA binding site [nucleotide binding] 693982015719 domain linker motif; other site 693982015720 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 693982015721 dimerization interface [polypeptide binding]; other site 693982015722 ligand binding site [chemical binding]; other site 693982015723 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982015724 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982015725 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982015726 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 693982015727 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982015728 putative NAD(P) binding site [chemical binding]; other site 693982015729 active site 693982015730 putative substrate binding site [chemical binding]; other site 693982015731 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 693982015732 putative active site [active] 693982015733 redox center [active] 693982015734 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 693982015735 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 693982015736 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693982015737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982015738 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 693982015739 dimerization interface [polypeptide binding]; other site 693982015740 substrate binding pocket [chemical binding]; other site 693982015741 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 693982015742 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 693982015743 active site 693982015744 DNA binding site [nucleotide binding] 693982015745 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 693982015746 DNA binding site [nucleotide binding] 693982015747 hydroperoxidase II; Provisional; Region: katE; PRK11249 693982015748 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 693982015749 tetramer interface [polypeptide binding]; other site 693982015750 heme binding pocket [chemical binding]; other site 693982015751 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 693982015752 domain interactions; other site 693982015753 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576 693982015754 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 693982015755 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693982015756 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 693982015757 putative C-terminal domain interface [polypeptide binding]; other site 693982015758 putative GSH binding site (G-site) [chemical binding]; other site 693982015759 putative dimer interface [polypeptide binding]; other site 693982015760 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 693982015761 putative N-terminal domain interface [polypeptide binding]; other site 693982015762 putative dimer interface [polypeptide binding]; other site 693982015763 putative substrate binding pocket (H-site) [chemical binding]; other site 693982015764 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982015765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982015766 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 693982015767 putative effector binding pocket; other site 693982015768 putative dimerization interface [polypeptide binding]; other site 693982015769 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 693982015770 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 693982015771 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982015772 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982015773 Walker A/P-loop; other site 693982015774 ATP binding site [chemical binding]; other site 693982015775 Q-loop/lid; other site 693982015776 ABC transporter signature motif; other site 693982015777 Walker B; other site 693982015778 D-loop; other site 693982015779 H-loop/switch region; other site 693982015780 TOBE domain; Region: TOBE_2; pfam08402 693982015781 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 693982015782 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 693982015783 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 693982015784 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 693982015785 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982015786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982015787 dimer interface [polypeptide binding]; other site 693982015788 conserved gate region; other site 693982015789 putative PBP binding loops; other site 693982015790 ABC-ATPase subunit interface; other site 693982015791 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982015792 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982015793 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 693982015794 oligomeric interface; other site 693982015795 putative active site [active] 693982015796 homodimer interface [polypeptide binding]; other site 693982015797 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982015798 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 693982015799 putative dimerization interface [polypeptide binding]; other site 693982015800 putative ligand binding site [chemical binding]; other site 693982015801 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693982015802 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693982015803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982015804 alpha-galactosidase; Provisional; Region: PRK15076 693982015805 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 693982015806 NAD binding site [chemical binding]; other site 693982015807 sugar binding site [chemical binding]; other site 693982015808 divalent metal binding site [ion binding]; other site 693982015809 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 693982015810 dimer interface [polypeptide binding]; other site 693982015811 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 693982015812 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 693982015813 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982015814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982015815 dimer interface [polypeptide binding]; other site 693982015816 conserved gate region; other site 693982015817 putative PBP binding loops; other site 693982015818 ABC-ATPase subunit interface; other site 693982015819 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982015820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982015821 dimer interface [polypeptide binding]; other site 693982015822 conserved gate region; other site 693982015823 putative PBP binding loops; other site 693982015824 ABC-ATPase subunit interface; other site 693982015825 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 693982015826 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982015827 Walker A/P-loop; other site 693982015828 ATP binding site [chemical binding]; other site 693982015829 Q-loop/lid; other site 693982015830 ABC transporter signature motif; other site 693982015831 Walker B; other site 693982015832 D-loop; other site 693982015833 H-loop/switch region; other site 693982015834 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982015835 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982015836 Walker A/P-loop; other site 693982015837 ATP binding site [chemical binding]; other site 693982015838 Q-loop/lid; other site 693982015839 ABC transporter signature motif; other site 693982015840 Walker B; other site 693982015841 D-loop; other site 693982015842 H-loop/switch region; other site 693982015843 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982015844 alpha-galactosidase; Provisional; Region: PRK15076 693982015845 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 693982015846 NAD binding site [chemical binding]; other site 693982015847 sugar binding site [chemical binding]; other site 693982015848 divalent metal binding site [ion binding]; other site 693982015849 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 693982015850 dimer interface [polypeptide binding]; other site 693982015851 Protein of unknown function (DUF992); Region: DUF992; pfam06186 693982015852 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 693982015853 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982015854 putative DNA binding site [nucleotide binding]; other site 693982015855 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 693982015856 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 693982015857 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 693982015858 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 693982015859 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 693982015860 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 693982015861 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 693982015862 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 693982015863 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 693982015864 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 693982015865 FAD binding pocket [chemical binding]; other site 693982015866 FAD binding motif [chemical binding]; other site 693982015867 phosphate binding motif [ion binding]; other site 693982015868 beta-alpha-beta structure motif; other site 693982015869 NAD(p) ribose binding residues [chemical binding]; other site 693982015870 NAD binding pocket [chemical binding]; other site 693982015871 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 693982015872 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982015873 catalytic loop [active] 693982015874 iron binding site [ion binding]; other site 693982015875 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 693982015876 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 693982015877 substrate binding site [chemical binding]; other site 693982015878 dimer interface [polypeptide binding]; other site 693982015879 NADP binding site [chemical binding]; other site 693982015880 catalytic residues [active] 693982015881 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 693982015882 substrate binding site [chemical binding]; other site 693982015883 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 693982015884 enoyl-CoA hydratase; Provisional; Region: PRK08140 693982015885 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693982015886 substrate binding site [chemical binding]; other site 693982015887 oxyanion hole (OAH) forming residues; other site 693982015888 trimer interface [polypeptide binding]; other site 693982015889 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 693982015890 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693982015891 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 693982015892 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693982015893 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 693982015894 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 693982015895 dimer interface [polypeptide binding]; other site 693982015896 active site 693982015897 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693982015898 catalytic residues [active] 693982015899 substrate binding site [chemical binding]; other site 693982015900 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 693982015901 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 693982015902 NAD(P) binding pocket [chemical binding]; other site 693982015903 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982015904 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982015905 DNA binding site [nucleotide binding] 693982015906 domain linker motif; other site 693982015907 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693982015908 dimerization interface [polypeptide binding]; other site 693982015909 ligand binding site [chemical binding]; other site 693982015910 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982015911 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982015912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982015913 dimer interface [polypeptide binding]; other site 693982015914 conserved gate region; other site 693982015915 putative PBP binding loops; other site 693982015916 ABC-ATPase subunit interface; other site 693982015917 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982015918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982015919 dimer interface [polypeptide binding]; other site 693982015920 conserved gate region; other site 693982015921 putative PBP binding loops; other site 693982015922 ABC-ATPase subunit interface; other site 693982015923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 693982015924 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 693982015925 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982015926 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982015927 Walker A/P-loop; other site 693982015928 ATP binding site [chemical binding]; other site 693982015929 Q-loop/lid; other site 693982015930 ABC transporter signature motif; other site 693982015931 Walker B; other site 693982015932 D-loop; other site 693982015933 H-loop/switch region; other site 693982015934 TOBE domain; Region: TOBE_2; pfam08402 693982015935 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 693982015936 Predicted transcriptional regulator [Transcription]; Region: COG3905 693982015937 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 693982015938 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 693982015939 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 693982015940 Phosphotransferase enzyme family; Region: APH; pfam01636 693982015941 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 693982015942 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982015943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982015944 Walker A/P-loop; other site 693982015945 ATP binding site [chemical binding]; other site 693982015946 Q-loop/lid; other site 693982015947 ABC transporter signature motif; other site 693982015948 Walker B; other site 693982015949 D-loop; other site 693982015950 H-loop/switch region; other site 693982015951 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982015952 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 693982015953 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982015954 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982015955 TM-ABC transporter signature motif; other site 693982015956 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 693982015957 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693982015958 putative ligand binding site [chemical binding]; other site 693982015959 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 693982015960 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 693982015961 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 693982015962 thiamine phosphate binding site [chemical binding]; other site 693982015963 active site 693982015964 pyrophosphate binding site [ion binding]; other site 693982015965 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 693982015966 ThiS interaction site; other site 693982015967 putative active site [active] 693982015968 tetramer interface [polypeptide binding]; other site 693982015969 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 693982015970 thiS-thiF/thiG interaction site; other site 693982015971 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 693982015972 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 693982015973 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 693982015974 ThiC-associated domain; Region: ThiC-associated; pfam13667 693982015975 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 693982015976 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693982015977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982015978 active site 693982015979 phosphorylation site [posttranslational modification] 693982015980 intermolecular recognition site; other site 693982015981 dimerization interface [polypeptide binding]; other site 693982015982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982015983 Walker A motif; other site 693982015984 ATP binding site [chemical binding]; other site 693982015985 Walker B motif; other site 693982015986 arginine finger; other site 693982015987 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 693982015988 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 693982015989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982015990 dimer interface [polypeptide binding]; other site 693982015991 phosphorylation site [posttranslational modification] 693982015992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982015993 ATP binding site [chemical binding]; other site 693982015994 Mg2+ binding site [ion binding]; other site 693982015995 G-X-G motif; other site 693982015996 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 693982015997 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693982015998 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982015999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982016000 active site 693982016001 phosphorylation site [posttranslational modification] 693982016002 intermolecular recognition site; other site 693982016003 dimerization interface [polypeptide binding]; other site 693982016004 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982016005 DNA binding residues [nucleotide binding] 693982016006 dimerization interface [polypeptide binding]; other site 693982016007 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 693982016008 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982016009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982016010 dimer interface [polypeptide binding]; other site 693982016011 phosphorylation site [posttranslational modification] 693982016012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982016013 ATP binding site [chemical binding]; other site 693982016014 Mg2+ binding site [ion binding]; other site 693982016015 G-X-G motif; other site 693982016016 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693982016017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982016018 active site 693982016019 phosphorylation site [posttranslational modification] 693982016020 intermolecular recognition site; other site 693982016021 dimerization interface [polypeptide binding]; other site 693982016022 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982016023 dimerization interface [polypeptide binding]; other site 693982016024 putative DNA binding site [nucleotide binding]; other site 693982016025 putative Zn2+ binding site [ion binding]; other site 693982016026 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 693982016027 putative hydrophobic ligand binding site [chemical binding]; other site 693982016028 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693982016029 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 693982016030 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 693982016031 putative ligand binding site [chemical binding]; other site 693982016032 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 693982016033 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982016034 TM-ABC transporter signature motif; other site 693982016035 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 693982016036 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 693982016037 TM-ABC transporter signature motif; other site 693982016038 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 693982016039 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 693982016040 Walker A/P-loop; other site 693982016041 ATP binding site [chemical binding]; other site 693982016042 Q-loop/lid; other site 693982016043 ABC transporter signature motif; other site 693982016044 Walker B; other site 693982016045 D-loop; other site 693982016046 H-loop/switch region; other site 693982016047 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 693982016048 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 693982016049 Walker A/P-loop; other site 693982016050 ATP binding site [chemical binding]; other site 693982016051 Q-loop/lid; other site 693982016052 ABC transporter signature motif; other site 693982016053 Walker B; other site 693982016054 D-loop; other site 693982016055 H-loop/switch region; other site 693982016056 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 693982016057 ParB-like nuclease domain; Region: ParBc; pfam02195 693982016058 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 693982016059 MerR family regulatory protein; Region: MerR; pfam00376 693982016060 DNA binding residues [nucleotide binding] 693982016061 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693982016062 P-loop; other site 693982016063 Magnesium ion binding site [ion binding]; other site 693982016064 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 693982016065 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693982016066 Magnesium ion binding site [ion binding]; other site 693982016067 Predicted membrane protein [Function unknown]; Region: COG2259 693982016068 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 693982016069 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 693982016070 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 693982016071 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 693982016072 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 693982016073 Predicted outer membrane protein [Function unknown]; Region: COG3652 693982016074 RNA polymerase sigma factor; Provisional; Region: PRK11922 693982016075 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982016076 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982016077 DNA binding residues [nucleotide binding] 693982016078 acylphosphatase; Provisional; Region: PRK14425 693982016079 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 693982016080 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693982016081 dimer interface [polypeptide binding]; other site 693982016082 active site 693982016083 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 693982016084 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 693982016085 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 693982016086 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 693982016087 Bacterial transcriptional regulator; Region: IclR; pfam01614 693982016088 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 693982016089 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 693982016090 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 693982016091 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 693982016092 Moco binding site; other site 693982016093 metal coordination site [ion binding]; other site 693982016094 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 693982016095 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982016096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982016097 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 693982016098 putative dimerization interface [polypeptide binding]; other site 693982016099 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693982016100 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 693982016101 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 693982016102 dimer interface [polypeptide binding]; other site 693982016103 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 693982016104 active site 693982016105 Fe binding site [ion binding]; other site 693982016106 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 693982016107 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982016108 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 693982016109 Transposase [DNA replication, recombination, and repair]; Region: COG5433 693982016110 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 693982016111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982016112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982016113 dimerization interface [polypeptide binding]; other site 693982016114 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693982016115 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 693982016116 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 693982016117 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 693982016118 heterodimer interface [polypeptide binding]; other site 693982016119 multimer interface [polypeptide binding]; other site 693982016120 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 693982016121 active site 693982016122 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 693982016123 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 693982016124 heterodimer interface [polypeptide binding]; other site 693982016125 active site 693982016126 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975 693982016127 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 693982016128 tetramer interface [polypeptide binding]; other site 693982016129 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 693982016130 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 693982016131 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 693982016132 active site 693982016133 catalytic site [active] 693982016134 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693982016135 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 693982016136 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 693982016137 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 693982016138 active site 693982016139 non-prolyl cis peptide bond; other site 693982016140 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693982016141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982016142 dimer interface [polypeptide binding]; other site 693982016143 conserved gate region; other site 693982016144 putative PBP binding loops; other site 693982016145 ABC-ATPase subunit interface; other site 693982016146 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 693982016147 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982016148 substrate binding pocket [chemical binding]; other site 693982016149 membrane-bound complex binding site; other site 693982016150 hinge residues; other site 693982016151 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 693982016152 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693982016153 Walker A/P-loop; other site 693982016154 ATP binding site [chemical binding]; other site 693982016155 Q-loop/lid; other site 693982016156 ABC transporter signature motif; other site 693982016157 Walker B; other site 693982016158 D-loop; other site 693982016159 H-loop/switch region; other site 693982016160 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 693982016161 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693982016162 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 693982016163 TM-ABC transporter signature motif; other site 693982016164 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 693982016165 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 693982016166 TM-ABC transporter signature motif; other site 693982016167 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 693982016168 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 693982016169 Walker A/P-loop; other site 693982016170 ATP binding site [chemical binding]; other site 693982016171 Q-loop/lid; other site 693982016172 ABC transporter signature motif; other site 693982016173 Walker B; other site 693982016174 D-loop; other site 693982016175 H-loop/switch region; other site 693982016176 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 693982016177 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 693982016178 Walker A/P-loop; other site 693982016179 ATP binding site [chemical binding]; other site 693982016180 Q-loop/lid; other site 693982016181 ABC transporter signature motif; other site 693982016182 Walker B; other site 693982016183 D-loop; other site 693982016184 H-loop/switch region; other site 693982016185 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 693982016186 CHASE2 domain; Region: CHASE2; pfam05226 693982016187 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982016188 cyclase homology domain; Region: CHD; cd07302 693982016189 nucleotidyl binding site; other site 693982016190 metal binding site [ion binding]; metal-binding site 693982016191 dimer interface [polypeptide binding]; other site 693982016192 FecR protein; Region: FecR; pfam04773 693982016193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982016194 TPR motif; other site 693982016195 TPR repeat; Region: TPR_11; pfam13414 693982016196 binding surface 693982016197 TPR repeat; Region: TPR_11; pfam13414 693982016198 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982016199 binding surface 693982016200 TPR motif; other site 693982016201 TPR repeat; Region: TPR_11; pfam13414 693982016202 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982016203 binding surface 693982016204 TPR motif; other site 693982016205 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693982016206 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982016207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982016208 DNA-binding site [nucleotide binding]; DNA binding site 693982016209 FCD domain; Region: FCD; pfam07729 693982016210 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 693982016211 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 693982016212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 693982016213 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 693982016214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 693982016215 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693982016216 dihydroxyacetone kinase; Provisional; Region: PRK14479 693982016217 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 693982016218 DAK2 domain; Region: Dak2; pfam02734 693982016219 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 693982016220 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 693982016221 trimer interface [polypeptide binding]; other site 693982016222 active site 693982016223 substrate binding site [chemical binding]; other site 693982016224 CoA binding site [chemical binding]; other site 693982016225 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 693982016226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982016227 Walker A/P-loop; other site 693982016228 ATP binding site [chemical binding]; other site 693982016229 Q-loop/lid; other site 693982016230 ABC transporter signature motif; other site 693982016231 Walker B; other site 693982016232 D-loop; other site 693982016233 H-loop/switch region; other site 693982016234 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 693982016235 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982016236 Walker A/P-loop; other site 693982016237 ATP binding site [chemical binding]; other site 693982016238 Q-loop/lid; other site 693982016239 ABC transporter signature motif; other site 693982016240 Walker B; other site 693982016241 D-loop; other site 693982016242 H-loop/switch region; other site 693982016243 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982016244 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 693982016245 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 693982016246 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 693982016247 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 693982016248 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 693982016249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982016250 DNA-binding site [nucleotide binding]; DNA binding site 693982016251 UTRA domain; Region: UTRA; pfam07702 693982016252 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 693982016253 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 693982016254 active site 693982016255 substrate binding site [chemical binding]; other site 693982016256 coenzyme B12 binding site [chemical binding]; other site 693982016257 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 693982016258 B12 binding site [chemical binding]; other site 693982016259 cobalt ligand [ion binding]; other site 693982016260 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 693982016261 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693982016262 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 693982016263 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693982016264 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693982016265 carboxyltransferase (CT) interaction site; other site 693982016266 biotinylation site [posttranslational modification]; other site 693982016267 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 693982016268 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 693982016269 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 693982016270 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982016271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982016272 non-specific DNA binding site [nucleotide binding]; other site 693982016273 salt bridge; other site 693982016274 sequence-specific DNA binding site [nucleotide binding]; other site 693982016275 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 693982016276 Domain of unknown function (DUF955); Region: DUF955; pfam06114 693982016277 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 693982016278 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693982016279 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 693982016280 substrate binding pocket [chemical binding]; other site 693982016281 FAD binding site [chemical binding]; other site 693982016282 catalytic base [active] 693982016283 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 693982016284 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693982016285 substrate binding site [chemical binding]; other site 693982016286 oxyanion hole (OAH) forming residues; other site 693982016287 trimer interface [polypeptide binding]; other site 693982016288 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 693982016289 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693982016290 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 693982016291 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 693982016292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982016293 NAD(P) binding site [chemical binding]; other site 693982016294 active site 693982016295 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 693982016296 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 693982016297 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 693982016298 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693982016299 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 693982016300 active site 693982016301 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 693982016302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982016303 motif II; other site 693982016304 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 693982016305 glutamine synthetase; Region: PLN02284 693982016306 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 693982016307 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693982016308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 693982016309 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 693982016310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 693982016311 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 693982016312 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 693982016313 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982016314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982016315 active site 693982016316 phosphorylation site [posttranslational modification] 693982016317 intermolecular recognition site; other site 693982016318 dimerization interface [polypeptide binding]; other site 693982016319 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982016320 DNA binding site [nucleotide binding] 693982016321 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 693982016322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982016323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982016324 dimer interface [polypeptide binding]; other site 693982016325 phosphorylation site [posttranslational modification] 693982016326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982016327 ATP binding site [chemical binding]; other site 693982016328 Mg2+ binding site [ion binding]; other site 693982016329 G-X-G motif; other site 693982016330 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982016331 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 693982016332 putative ligand binding site [chemical binding]; other site 693982016333 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982016334 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982016335 TM-ABC transporter signature motif; other site 693982016336 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982016337 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982016338 Walker A/P-loop; other site 693982016339 ATP binding site [chemical binding]; other site 693982016340 Q-loop/lid; other site 693982016341 ABC transporter signature motif; other site 693982016342 Walker B; other site 693982016343 D-loop; other site 693982016344 H-loop/switch region; other site 693982016345 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982016346 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982016347 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982016348 DNA binding site [nucleotide binding] 693982016349 domain linker motif; other site 693982016350 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 693982016351 dimerization interface [polypeptide binding]; other site 693982016352 ligand binding site [chemical binding]; other site 693982016353 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693982016354 EamA-like transporter family; Region: EamA; pfam00892 693982016355 EamA-like transporter family; Region: EamA; pfam00892 693982016356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982016357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982016358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693982016359 dimerization interface [polypeptide binding]; other site 693982016360 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982016361 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982016362 TM-ABC transporter signature motif; other site 693982016363 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982016364 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982016365 Walker A/P-loop; other site 693982016366 ATP binding site [chemical binding]; other site 693982016367 Q-loop/lid; other site 693982016368 ABC transporter signature motif; other site 693982016369 Walker B; other site 693982016370 D-loop; other site 693982016371 H-loop/switch region; other site 693982016372 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982016373 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982016374 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 693982016375 putative ligand binding site [chemical binding]; other site 693982016376 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 693982016377 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 693982016378 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693982016379 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 693982016380 active site 693982016381 DNA binding site [nucleotide binding] 693982016382 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 693982016383 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693982016384 DNA binding site [nucleotide binding] 693982016385 active site 693982016386 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982016387 cyclase homology domain; Region: CHD; cd07302 693982016388 nucleotidyl binding site; other site 693982016389 metal binding site [ion binding]; metal-binding site 693982016390 dimer interface [polypeptide binding]; other site 693982016391 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 693982016392 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982016393 substrate binding pocket [chemical binding]; other site 693982016394 membrane-bound complex binding site; other site 693982016395 hinge residues; other site 693982016396 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693982016397 EamA-like transporter family; Region: EamA; pfam00892 693982016398 glycogen synthase; Provisional; Region: glgA; PRK00654 693982016399 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 693982016400 ADP-binding pocket [chemical binding]; other site 693982016401 homodimer interface [polypeptide binding]; other site 693982016402 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 693982016403 substrate binding site [chemical binding]; other site 693982016404 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982016405 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982016406 DNA binding site [nucleotide binding] 693982016407 Predicted integral membrane protein [Function unknown]; Region: COG5616 693982016408 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 693982016409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982016410 TPR motif; other site 693982016411 binding surface 693982016412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982016413 binding surface 693982016414 TPR motif; other site 693982016415 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 693982016416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982016417 NAD(P) binding site [chemical binding]; other site 693982016418 active site 693982016419 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 693982016420 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 693982016421 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982016422 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982016423 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 693982016424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982016425 putative substrate translocation pore; other site 693982016426 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 693982016427 putative metal binding site [ion binding]; other site 693982016428 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 693982016429 putative dimer interface [polypeptide binding]; other site 693982016430 Uncharacterized conserved protein [Function unknown]; Region: COG5642 693982016431 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 693982016432 Uncharacterized conserved protein [Function unknown]; Region: COG5654 693982016433 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 693982016434 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 693982016435 NADP binding site [chemical binding]; other site 693982016436 homodimer interface [polypeptide binding]; other site 693982016437 active site 693982016438 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 693982016439 putative catalytic site [active] 693982016440 putative phosphate binding site [ion binding]; other site 693982016441 active site 693982016442 metal binding site A [ion binding]; metal-binding site 693982016443 DNA binding site [nucleotide binding] 693982016444 putative AP binding site [nucleotide binding]; other site 693982016445 putative metal binding site B [ion binding]; other site 693982016446 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 693982016447 TPR repeat; Region: TPR_11; pfam13414 693982016448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982016449 binding surface 693982016450 TPR motif; other site 693982016451 TPR repeat; Region: TPR_11; pfam13414 693982016452 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 693982016453 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 693982016454 putative DNA binding site [nucleotide binding]; other site 693982016455 putative homodimer interface [polypeptide binding]; other site 693982016456 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 693982016457 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 693982016458 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 693982016459 active site 693982016460 DNA binding site [nucleotide binding] 693982016461 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 693982016462 DNA binding site [nucleotide binding] 693982016463 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 693982016464 nucleotide binding site [chemical binding]; other site 693982016465 hypothetical protein; Provisional; Region: PRK11171 693982016466 Cupin domain; Region: Cupin_2; pfam07883 693982016467 Cupin domain; Region: Cupin_2; pfam07883 693982016468 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 693982016469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982016470 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 693982016471 putative dimerization interface [polypeptide binding]; other site 693982016472 putative substrate binding pocket [chemical binding]; other site 693982016473 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 693982016474 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693982016475 Bacterial transcriptional regulator; Region: IclR; pfam01614 693982016476 glyoxylate carboligase; Provisional; Region: PRK11269 693982016477 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693982016478 PYR/PP interface [polypeptide binding]; other site 693982016479 dimer interface [polypeptide binding]; other site 693982016480 TPP binding site [chemical binding]; other site 693982016481 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693982016482 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 693982016483 TPP-binding site [chemical binding]; other site 693982016484 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 693982016485 tartronate semialdehyde reductase; Provisional; Region: PRK15059 693982016486 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693982016487 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 693982016488 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 693982016489 MOFRL family; Region: MOFRL; pfam05161 693982016490 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 693982016491 ureidoglycolate hydrolase; Provisional; Region: PRK13395 693982016492 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 693982016493 Uncharacterized conserved protein [Function unknown]; Region: COG3506 693982016494 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982016495 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982016496 DNA binding site [nucleotide binding] 693982016497 domain linker motif; other site 693982016498 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693982016499 dimerization interface [polypeptide binding]; other site 693982016500 ligand binding site [chemical binding]; other site 693982016501 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982016502 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982016503 Walker A/P-loop; other site 693982016504 ATP binding site [chemical binding]; other site 693982016505 Q-loop/lid; other site 693982016506 ABC transporter signature motif; other site 693982016507 Walker B; other site 693982016508 D-loop; other site 693982016509 H-loop/switch region; other site 693982016510 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982016511 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 693982016512 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982016513 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982016514 TM-ABC transporter signature motif; other site 693982016515 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982016516 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 693982016517 putative ligand binding site [chemical binding]; other site 693982016518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 693982016519 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 693982016520 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 693982016521 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693982016522 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982016523 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982016524 DNA binding site [nucleotide binding] 693982016525 domain linker motif; other site 693982016526 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 693982016527 putative dimerization interface [polypeptide binding]; other site 693982016528 putative ligand binding site [chemical binding]; other site 693982016529 putative aldolase; Validated; Region: PRK08130 693982016530 intersubunit interface [polypeptide binding]; other site 693982016531 active site 693982016532 Zn2+ binding site [ion binding]; other site 693982016533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693982016534 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693982016535 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693982016536 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982016537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982016538 DNA-binding site [nucleotide binding]; DNA binding site 693982016539 FCD domain; Region: FCD; pfam07729 693982016540 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982016541 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 693982016542 putative NAD(P) binding site [chemical binding]; other site 693982016543 active site 693982016544 putative substrate binding site [chemical binding]; other site 693982016545 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693982016546 classical (c) SDRs; Region: SDR_c; cd05233 693982016547 NAD(P) binding site [chemical binding]; other site 693982016548 active site 693982016549 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982016550 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982016551 Walker A/P-loop; other site 693982016552 ATP binding site [chemical binding]; other site 693982016553 Q-loop/lid; other site 693982016554 ABC transporter signature motif; other site 693982016555 Walker B; other site 693982016556 D-loop; other site 693982016557 H-loop/switch region; other site 693982016558 TOBE domain; Region: TOBE; pfam03459 693982016559 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982016560 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982016561 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982016562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982016563 dimer interface [polypeptide binding]; other site 693982016564 conserved gate region; other site 693982016565 putative PBP binding loops; other site 693982016566 ABC-ATPase subunit interface; other site 693982016567 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982016568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982016569 dimer interface [polypeptide binding]; other site 693982016570 conserved gate region; other site 693982016571 putative PBP binding loops; other site 693982016572 ABC-ATPase subunit interface; other site 693982016573 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982016574 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982016575 active site 693982016576 catalytic tetrad [active] 693982016577 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 693982016578 dimer interface [polypeptide binding]; other site 693982016579 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 693982016580 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 693982016581 active site 693982016582 dimer interface [polypeptide binding]; other site 693982016583 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 693982016584 Ligand Binding Site [chemical binding]; other site 693982016585 Molecular Tunnel; other site 693982016586 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 693982016587 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 693982016588 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693982016589 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 693982016590 acyl-activating enzyme (AAE) consensus motif; other site 693982016591 putative AMP binding site [chemical binding]; other site 693982016592 putative active site [active] 693982016593 putative CoA binding site [chemical binding]; other site 693982016594 NAD synthetase; Reviewed; Region: nadE; PRK00876 693982016595 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 693982016596 homodimer interface [polypeptide binding]; other site 693982016597 NAD binding pocket [chemical binding]; other site 693982016598 ATP binding pocket [chemical binding]; other site 693982016599 Mg binding site [ion binding]; other site 693982016600 active-site loop [active] 693982016601 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982016602 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982016603 active site 693982016604 catalytic tetrad [active] 693982016605 septum formation inhibitor; Reviewed; Region: minC; PRK05177 693982016606 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 693982016607 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 693982016608 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 693982016609 Switch I; other site 693982016610 Switch II; other site 693982016611 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 693982016612 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982016613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982016614 active site 693982016615 phosphorylation site [posttranslational modification] 693982016616 intermolecular recognition site; other site 693982016617 dimerization interface [polypeptide binding]; other site 693982016618 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982016619 DNA binding residues [nucleotide binding] 693982016620 dimerization interface [polypeptide binding]; other site 693982016621 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 693982016622 Histidine kinase; Region: HisKA_3; pfam07730 693982016623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982016624 ATP binding site [chemical binding]; other site 693982016625 Mg2+ binding site [ion binding]; other site 693982016626 G-X-G motif; other site 693982016627 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693982016628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 693982016629 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693982016630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693982016631 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 693982016632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982016633 S-adenosylmethionine binding site [chemical binding]; other site 693982016634 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 693982016635 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 693982016636 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 693982016637 inhibitor site; inhibition site 693982016638 active site 693982016639 dimer interface [polypeptide binding]; other site 693982016640 catalytic residue [active] 693982016641 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 693982016642 Chain length determinant protein; Region: Wzz; cl15801 693982016643 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 693982016644 O-Antigen ligase; Region: Wzy_C; pfam04932 693982016645 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 693982016646 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 693982016647 putative active site [active] 693982016648 putative metal binding site [ion binding]; other site 693982016649 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982016650 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 693982016651 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982016652 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 693982016653 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693982016654 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 693982016655 active site 693982016656 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693982016657 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693982016658 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982016659 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982016660 ornithine cyclodeaminase; Validated; Region: PRK07589 693982016661 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 693982016662 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693982016663 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 693982016664 putative DNA binding site [nucleotide binding]; other site 693982016665 putative Zn2+ binding site [ion binding]; other site 693982016666 AsnC family; Region: AsnC_trans_reg; pfam01037 693982016667 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664 693982016668 Protein of unknown function (DUF992); Region: DUF992; pfam06186 693982016669 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 693982016670 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 693982016671 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 693982016672 Subunit I/III interface [polypeptide binding]; other site 693982016673 Subunit III/IV interface [polypeptide binding]; other site 693982016674 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 693982016675 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 693982016676 D-pathway; other site 693982016677 Putative ubiquinol binding site [chemical binding]; other site 693982016678 Low-spin heme (heme b) binding site [chemical binding]; other site 693982016679 Putative water exit pathway; other site 693982016680 Binuclear center (heme o3/CuB) [ion binding]; other site 693982016681 K-pathway; other site 693982016682 Putative proton exit pathway; other site 693982016683 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 693982016684 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 693982016685 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 693982016686 metabolite-proton symporter; Region: 2A0106; TIGR00883 693982016687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982016688 RNA polymerase sigma factor; Provisional; Region: PRK12547 693982016689 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982016690 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982016691 DNA binding residues [nucleotide binding] 693982016692 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 693982016693 FOG: CBS domain [General function prediction only]; Region: COG0517 693982016694 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 693982016695 Protein of unknown function (DUF982); Region: DUF982; pfam06169 693982016696 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693982016697 classical (c) SDRs; Region: SDR_c; cd05233 693982016698 NAD(P) binding site [chemical binding]; other site 693982016699 active site 693982016700 Predicted small integral membrane protein [Function unknown]; Region: COG5478 693982016701 Protein of unknown function (DUF982); Region: DUF982; pfam06169 693982016702 Protein of unknown function (DUF982); Region: DUF982; pfam06169 693982016703 Protein of unknown function (DUF982); Region: DUF982; pfam06169 693982016704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 693982016705 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 693982016706 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 693982016707 Walker A/P-loop; other site 693982016708 ATP binding site [chemical binding]; other site 693982016709 Q-loop/lid; other site 693982016710 ABC transporter signature motif; other site 693982016711 Walker B; other site 693982016712 D-loop; other site 693982016713 H-loop/switch region; other site 693982016714 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 693982016715 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982016716 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982016717 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693982016718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982016719 DNA-binding site [nucleotide binding]; DNA binding site 693982016720 UTRA domain; Region: UTRA; pfam07702 693982016721 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 693982016722 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 693982016723 NAD binding site [chemical binding]; other site 693982016724 sugar binding site [chemical binding]; other site 693982016725 divalent metal binding site [ion binding]; other site 693982016726 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693982016727 dimer interface [polypeptide binding]; other site 693982016728 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693982016729 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 693982016730 substrate binding site [chemical binding]; other site 693982016731 ATP binding site [chemical binding]; other site 693982016732 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982016733 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982016734 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693982016735 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982016736 Walker A/P-loop; other site 693982016737 ATP binding site [chemical binding]; other site 693982016738 Q-loop/lid; other site 693982016739 ABC transporter signature motif; other site 693982016740 Walker B; other site 693982016741 D-loop; other site 693982016742 H-loop/switch region; other site 693982016743 TOBE domain; Region: TOBE_2; pfam08402 693982016744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982016745 dimer interface [polypeptide binding]; other site 693982016746 conserved gate region; other site 693982016747 putative PBP binding loops; other site 693982016748 ABC-ATPase subunit interface; other site 693982016749 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982016750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982016751 dimer interface [polypeptide binding]; other site 693982016752 conserved gate region; other site 693982016753 putative PBP binding loops; other site 693982016754 ABC-ATPase subunit interface; other site 693982016755 Uncharacterized conserved protein [Function unknown]; Region: COG1415 693982016756 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 693982016757 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 693982016758 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 693982016759 Fe-S cluster binding site [ion binding]; other site 693982016760 active site 693982016761 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 693982016762 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 693982016763 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 693982016764 catalytic site [active] 693982016765 active site 693982016766 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 693982016767 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 693982016768 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 693982016769 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 693982016770 active site 693982016771 catalytic site [active] 693982016772 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 693982016773 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 693982016774 active site 693982016775 DNA binding site [nucleotide binding] 693982016776 Int/Topo IB signature motif; other site 693982016777 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 693982016778 BON domain; Region: BON; pfam04972 693982016779 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 693982016780 FOG: CBS domain [General function prediction only]; Region: COG0517 693982016781 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 693982016782 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 693982016783 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693982016784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982016785 S-adenosylmethionine binding site [chemical binding]; other site 693982016786 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 693982016787 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 693982016788 putative ligand binding residues [chemical binding]; other site 693982016789 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 693982016790 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693982016791 ABC-ATPase subunit interface; other site 693982016792 dimer interface [polypeptide binding]; other site 693982016793 putative PBP binding regions; other site 693982016794 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 693982016795 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693982016796 Walker A/P-loop; other site 693982016797 ATP binding site [chemical binding]; other site 693982016798 Q-loop/lid; other site 693982016799 ABC transporter signature motif; other site 693982016800 Walker B; other site 693982016801 D-loop; other site 693982016802 H-loop/switch region; other site 693982016803 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 693982016804 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 693982016805 putative trimer interface [polypeptide binding]; other site 693982016806 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 693982016807 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 693982016808 trimer interface [polypeptide binding]; other site 693982016809 active site 693982016810 substrate binding site [chemical binding]; other site 693982016811 putative CoA binding site [chemical binding]; other site 693982016812 CoA binding site [chemical binding]; other site 693982016813 extended (e) SDRs; Region: SDR_e; cd08946 693982016814 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 693982016815 NAD(P) binding site [chemical binding]; other site 693982016816 active site 693982016817 substrate binding site [chemical binding]; other site 693982016818 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 693982016819 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982016820 Transposase domain (DUF772); Region: DUF772; pfam05598 693982016821 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982016822 transposase; Validated; Region: PRK08181 693982016823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982016824 Walker A motif; other site 693982016825 ATP binding site [chemical binding]; other site 693982016826 Walker B motif; other site 693982016827 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982016828 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 693982016829 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693982016830 Methyltransferase domain; Region: Methyltransf_12; pfam08242 693982016831 S-adenosylmethionine binding site [chemical binding]; other site 693982016832 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 693982016833 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 693982016834 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 693982016835 NAD binding site [chemical binding]; other site 693982016836 homotetramer interface [polypeptide binding]; other site 693982016837 homodimer interface [polypeptide binding]; other site 693982016838 substrate binding site [chemical binding]; other site 693982016839 active site 693982016840 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 693982016841 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 693982016842 substrate binding site; other site 693982016843 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693982016844 FAD binding domain; Region: FAD_binding_4; pfam01565 693982016845 Berberine and berberine like; Region: BBE; pfam08031 693982016846 tyrosine decarboxylase; Region: PLN02880 693982016847 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 693982016848 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693982016849 catalytic residue [active] 693982016850 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 693982016851 Ca2+ binding site [ion binding]; other site 693982016852 Uncharacterized conserved protein [Function unknown]; Region: COG3189 693982016853 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693982016854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982016855 S-adenosylmethionine binding site [chemical binding]; other site 693982016856 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 693982016857 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 693982016858 putative DNA binding site [nucleotide binding]; other site 693982016859 putative homodimer interface [polypeptide binding]; other site 693982016860 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 693982016861 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 693982016862 putative DNA binding site [nucleotide binding]; other site 693982016863 putative homodimer interface [polypeptide binding]; other site 693982016864 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 693982016865 catalytic triad [active] 693982016866 dimer interface [polypeptide binding]; other site 693982016867 conserved cis-peptide bond; other site 693982016868 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 693982016869 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 693982016870 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 693982016871 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 693982016872 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 693982016873 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982016874 Walker A/P-loop; other site 693982016875 ATP binding site [chemical binding]; other site 693982016876 Q-loop/lid; other site 693982016877 ABC transporter signature motif; other site 693982016878 Walker B; other site 693982016879 D-loop; other site 693982016880 H-loop/switch region; other site 693982016881 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982016882 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982016883 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982016884 TM-ABC transporter signature motif; other site 693982016885 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 693982016886 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 693982016887 putative ligand binding site [chemical binding]; other site 693982016888 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 693982016889 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693982016890 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693982016891 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982016892 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982016893 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982016894 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982016895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982016896 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 693982016897 putative dimerization interface [polypeptide binding]; other site 693982016898 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 693982016899 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 693982016900 putative ligand binding site [chemical binding]; other site 693982016901 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982016902 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982016903 Walker A/P-loop; other site 693982016904 ATP binding site [chemical binding]; other site 693982016905 Q-loop/lid; other site 693982016906 ABC transporter signature motif; other site 693982016907 Walker B; other site 693982016908 D-loop; other site 693982016909 H-loop/switch region; other site 693982016910 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982016911 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982016912 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982016913 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982016914 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982016915 TM-ABC transporter signature motif; other site 693982016916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 693982016917 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693982016918 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 693982016919 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693982016920 NAD(P) binding site [chemical binding]; other site 693982016921 catalytic residues [active] 693982016922 dihydroxy-acid dehydratase; Validated; Region: PRK06131 693982016923 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 693982016924 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 693982016925 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 693982016926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 693982016927 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 693982016928 Uncharacterized conserved protein [Function unknown]; Region: COG2308 693982016929 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693982016930 EamA-like transporter family; Region: EamA; pfam00892 693982016931 YtkA-like; Region: YtkA; pfam13115 693982016932 Predicted metal-binding protein [General function prediction only]; Region: COG3019 693982016933 helicase 45; Provisional; Region: PTZ00424 693982016934 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693982016935 ATP binding site [chemical binding]; other site 693982016936 Mg++ binding site [ion binding]; other site 693982016937 motif III; other site 693982016938 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693982016939 nucleotide binding region [chemical binding]; other site 693982016940 ATP-binding site [chemical binding]; other site 693982016941 Protein required for attachment to host cells [Cell motility and secretion]; Region: COG5622 693982016942 Uncharacterized conserved protein [Function unknown]; Region: COG4121 693982016943 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982016944 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 693982016945 Protein of unknown function (DUF1045); Region: DUF1045; pfam06299 693982016946 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 693982016947 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 693982016948 active site 693982016949 catalytic site [active] 693982016950 tetramer interface [polypeptide binding]; other site 693982016951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 693982016952 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 693982016953 ureidoglycolate hydrolase; Provisional; Region: PRK03606 693982016954 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 693982016955 active site 693982016956 homotetramer interface [polypeptide binding]; other site 693982016957 short chain dehydrogenase; Provisional; Region: PRK06500 693982016958 classical (c) SDRs; Region: SDR_c; cd05233 693982016959 NAD(P) binding site [chemical binding]; other site 693982016960 active site 693982016961 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982016962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982016963 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693982016964 putative effector binding pocket; other site 693982016965 dimerization interface [polypeptide binding]; other site 693982016966 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 693982016967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982016968 active site 693982016969 phosphorylation site [posttranslational modification] 693982016970 intermolecular recognition site; other site 693982016971 dimerization interface [polypeptide binding]; other site 693982016972 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982016973 DNA binding residues [nucleotide binding] 693982016974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982016975 active site 693982016976 phosphorylation site [posttranslational modification] 693982016977 intermolecular recognition site; other site 693982016978 dimerization interface [polypeptide binding]; other site 693982016979 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 693982016980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982016981 PAS fold; Region: PAS_3; pfam08447 693982016982 putative active site [active] 693982016983 heme pocket [chemical binding]; other site 693982016984 PAS domain; Region: PAS_9; pfam13426 693982016985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982016986 PAS domain; Region: PAS_9; pfam13426 693982016987 putative active site [active] 693982016988 heme pocket [chemical binding]; other site 693982016989 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982016990 PAS fold; Region: PAS_3; pfam08447 693982016991 putative active site [active] 693982016992 heme pocket [chemical binding]; other site 693982016993 PAS fold; Region: PAS_3; pfam08447 693982016994 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982016995 putative active site [active] 693982016996 heme pocket [chemical binding]; other site 693982016997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982016998 ATP binding site [chemical binding]; other site 693982016999 Mg2+ binding site [ion binding]; other site 693982017000 G-X-G motif; other site 693982017001 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693982017002 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 693982017003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982017004 NAD(P) binding site [chemical binding]; other site 693982017005 active site 693982017006 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 693982017007 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693982017008 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693982017009 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 693982017010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982017011 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693982017012 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693982017013 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693982017014 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982017015 glucose-6-phosphate isomerase; Provisional; Region: PRK04190 693982017016 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 693982017017 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 693982017018 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693982017019 putative ligand binding site [chemical binding]; other site 693982017020 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982017021 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982017022 Walker A/P-loop; other site 693982017023 ATP binding site [chemical binding]; other site 693982017024 Q-loop/lid; other site 693982017025 ABC transporter signature motif; other site 693982017026 Walker B; other site 693982017027 D-loop; other site 693982017028 H-loop/switch region; other site 693982017029 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982017030 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982017031 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982017032 TM-ABC transporter signature motif; other site 693982017033 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693982017034 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 693982017035 putative NAD(P) binding site [chemical binding]; other site 693982017036 catalytic Zn binding site [ion binding]; other site 693982017037 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 693982017038 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 693982017039 N- and C-terminal domain interface [polypeptide binding]; other site 693982017040 active site 693982017041 MgATP binding site [chemical binding]; other site 693982017042 catalytic site [active] 693982017043 metal binding site [ion binding]; metal-binding site 693982017044 putative carbohydrate binding site [chemical binding]; other site 693982017045 putative homodimer interface [polypeptide binding]; other site 693982017046 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 693982017047 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 693982017048 DNA binding residues [nucleotide binding] 693982017049 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 693982017050 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 693982017051 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 693982017052 active site 693982017053 substrate binding site [chemical binding]; other site 693982017054 FMN binding site [chemical binding]; other site 693982017055 putative catalytic residues [active] 693982017056 guanine deaminase; Provisional; Region: PRK09228 693982017057 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 693982017058 active site 693982017059 Predicted membrane protein [Function unknown]; Region: COG3748 693982017060 Protein of unknown function (DUF989); Region: DUF989; pfam06181 693982017061 Cytochrome c; Region: Cytochrom_C; pfam00034 693982017062 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693982017063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982017064 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693982017065 dimerization interface [polypeptide binding]; other site 693982017066 substrate binding pocket [chemical binding]; other site 693982017067 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 693982017068 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693982017069 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982017070 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 693982017071 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982017072 catalytic loop [active] 693982017073 iron binding site [ion binding]; other site 693982017074 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693982017075 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 693982017076 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 693982017077 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 693982017078 NAD binding site [chemical binding]; other site 693982017079 homotetramer interface [polypeptide binding]; other site 693982017080 homodimer interface [polypeptide binding]; other site 693982017081 substrate binding site [chemical binding]; other site 693982017082 active site 693982017083 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 693982017084 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 693982017085 N- and C-terminal domain interface [polypeptide binding]; other site 693982017086 active site 693982017087 MgATP binding site [chemical binding]; other site 693982017088 catalytic site [active] 693982017089 metal binding site [ion binding]; metal-binding site 693982017090 glycerol binding site [chemical binding]; other site 693982017091 homotetramer interface [polypeptide binding]; other site 693982017092 homodimer interface [polypeptide binding]; other site 693982017093 FBP binding site [chemical binding]; other site 693982017094 protein IIAGlc interface [polypeptide binding]; other site 693982017095 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982017096 dimerization interface [polypeptide binding]; other site 693982017097 putative DNA binding site [nucleotide binding]; other site 693982017098 putative Zn2+ binding site [ion binding]; other site 693982017099 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 693982017100 putative hydrophobic ligand binding site [chemical binding]; other site 693982017101 Uncharacterized conserved protein [Function unknown]; Region: COG5649 693982017102 Uncharacterized conserved protein [Function unknown]; Region: COG5649 693982017103 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 693982017104 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 693982017105 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 693982017106 active site 693982017107 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 693982017108 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982017109 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 693982017110 Transposase [DNA replication, recombination, and repair]; Region: COG5433 693982017111 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 693982017112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982017113 microcin B17 transporter; Reviewed; Region: PRK11098 693982017114 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 693982017115 NodB motif; other site 693982017116 putative active site [active] 693982017117 putative catalytic site [active] 693982017118 Predicted membrane protein [Function unknown]; Region: COG4094 693982017119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 693982017120 GTP-binding protein Der; Reviewed; Region: PRK00093 693982017121 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 693982017122 G1 box; other site 693982017123 GTP/Mg2+ binding site [chemical binding]; other site 693982017124 Switch I region; other site 693982017125 G2 box; other site 693982017126 Switch II region; other site 693982017127 G3 box; other site 693982017128 G4 box; other site 693982017129 G5 box; other site 693982017130 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 693982017131 G1 box; other site 693982017132 GTP/Mg2+ binding site [chemical binding]; other site 693982017133 Switch I region; other site 693982017134 G2 box; other site 693982017135 G3 box; other site 693982017136 Switch II region; other site 693982017137 G4 box; other site 693982017138 G5 box; other site 693982017139 Predicted transcriptional regulator [Transcription]; Region: COG1959 693982017140 Transcriptional regulator; Region: Rrf2; pfam02082 693982017141 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 693982017142 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693982017143 active site 693982017144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 693982017145 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 693982017146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 693982017147 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 693982017148 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 693982017149 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 693982017150 dimer interface [polypeptide binding]; other site 693982017151 active site residues [active] 693982017152 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 693982017153 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 693982017154 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 693982017155 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 693982017156 nudix motif; other site 693982017157 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 693982017158 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 693982017159 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 693982017160 Uroporphyrinogen-III methylase [Coenzyme metabolism]; Region: CysG; COG0007 693982017161 homodimer interface [polypeptide binding]; other site 693982017162 active site 693982017163 SAM binding site [chemical binding]; other site 693982017164 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 693982017165 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 693982017166 [4Fe-4S] binding site [ion binding]; other site 693982017167 molybdopterin cofactor binding site; other site 693982017168 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 693982017169 molybdopterin cofactor binding site; other site 693982017170 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 693982017171 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 693982017172 [2Fe-2S] cluster binding site [ion binding]; other site 693982017173 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 693982017174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982017175 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 693982017176 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 693982017177 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693982017178 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693982017179 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 693982017180 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693982017181 DctM-like transporters; Region: DctM; pfam06808 693982017182 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693982017183 Acyl dehydratase [Lipid metabolism]; Region: MaoC; COG2030 693982017184 active site 2 [active] 693982017185 active site 1 [active] 693982017186 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982017187 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982017188 DNA binding site [nucleotide binding] 693982017189 domain linker motif; other site 693982017190 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 693982017191 ligand binding site [chemical binding]; other site 693982017192 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693982017193 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982017194 substrate binding pocket [chemical binding]; other site 693982017195 membrane-bound complex binding site; other site 693982017196 hinge residues; other site 693982017197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982017198 dimer interface [polypeptide binding]; other site 693982017199 conserved gate region; other site 693982017200 putative PBP binding loops; other site 693982017201 ABC-ATPase subunit interface; other site 693982017202 C factor cell-cell signaling protein; Provisional; Region: PRK09009 693982017203 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 693982017204 NADP binding site [chemical binding]; other site 693982017205 homodimer interface [polypeptide binding]; other site 693982017206 active site 693982017207 hypothetical protein; Provisional; Region: PRK06148 693982017208 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 693982017209 active site 693982017210 ATP binding site [chemical binding]; other site 693982017211 substrate binding site [chemical binding]; other site 693982017212 Peptidase family M23; Region: Peptidase_M23; pfam01551 693982017213 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693982017214 inhibitor-cofactor binding pocket; inhibition site 693982017215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982017216 catalytic residue [active] 693982017217 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982017218 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982017219 Walker A/P-loop; other site 693982017220 ATP binding site [chemical binding]; other site 693982017221 Q-loop/lid; other site 693982017222 ABC transporter signature motif; other site 693982017223 Walker B; other site 693982017224 D-loop; other site 693982017225 H-loop/switch region; other site 693982017226 TOBE domain; Region: TOBE_2; pfam08402 693982017227 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982017228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982017229 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982017230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982017231 dimer interface [polypeptide binding]; other site 693982017232 conserved gate region; other site 693982017233 putative PBP binding loops; other site 693982017234 ABC-ATPase subunit interface; other site 693982017235 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982017236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982017237 dimer interface [polypeptide binding]; other site 693982017238 conserved gate region; other site 693982017239 putative PBP binding loops; other site 693982017240 ABC-ATPase subunit interface; other site 693982017241 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 693982017242 Trehalase; Region: Trehalase; cl17346 693982017243 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982017244 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982017245 DNA binding site [nucleotide binding] 693982017246 domain linker motif; other site 693982017247 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 693982017248 ligand binding site [chemical binding]; other site 693982017249 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 693982017250 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 693982017251 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 693982017252 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 693982017253 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 693982017254 Beta-lactamase; Region: Beta-lactamase; pfam00144 693982017255 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 693982017256 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 693982017257 dimer interface [polypeptide binding]; other site 693982017258 decamer (pentamer of dimers) interface [polypeptide binding]; other site 693982017259 catalytic triad [active] 693982017260 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 693982017261 substrate binding site [chemical binding]; other site 693982017262 dimer interface [polypeptide binding]; other site 693982017263 ATP binding site [chemical binding]; other site 693982017264 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 693982017265 Chain length determinant protein; Region: Wzz; pfam02706 693982017266 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 693982017267 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693982017268 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 693982017269 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 693982017270 active site 693982017271 tetramer interface; other site 693982017272 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 693982017273 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693982017274 active site 693982017275 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 693982017276 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693982017277 active site 693982017278 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693982017279 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 693982017280 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 693982017281 Ligand binding site; other site 693982017282 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693982017283 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 693982017284 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 693982017285 active site 693982017286 active site 693982017287 catalytic residues [active] 693982017288 Acyltransferase family; Region: Acyl_transf_3; pfam01757 693982017289 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 693982017290 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 693982017291 Catalytic site; other site 693982017292 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 693982017293 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 693982017294 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 693982017295 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693982017296 active site 693982017297 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 693982017298 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693982017299 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693982017300 active site 693982017301 Exopolysaccharide production repressor; Region: SyrA; pfam11089 693982017302 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 693982017303 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 693982017304 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 693982017305 SLBB domain; Region: SLBB; pfam10531 693982017306 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 693982017307 O-Antigen ligase; Region: Wzy_C; pfam04932 693982017308 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 693982017309 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 693982017310 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 693982017311 NAD binding site [chemical binding]; other site 693982017312 homodimer interface [polypeptide binding]; other site 693982017313 active site 693982017314 substrate binding site [chemical binding]; other site 693982017315 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693982017316 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 693982017317 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 693982017318 Walker A/P-loop; other site 693982017319 ATP binding site [chemical binding]; other site 693982017320 Q-loop/lid; other site 693982017321 ABC transporter signature motif; other site 693982017322 Walker B; other site 693982017323 D-loop; other site 693982017324 H-loop/switch region; other site 693982017325 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 693982017326 Ligand Binding Site [chemical binding]; other site 693982017327 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 693982017328 active site 693982017329 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 693982017330 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 693982017331 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 693982017332 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 693982017333 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 693982017334 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982017335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982017336 non-specific DNA binding site [nucleotide binding]; other site 693982017337 salt bridge; other site 693982017338 sequence-specific DNA binding site [nucleotide binding]; other site 693982017339 Response regulator receiver domain; Region: Response_reg; pfam00072 693982017340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982017341 active site 693982017342 phosphorylation site [posttranslational modification] 693982017343 intermolecular recognition site; other site 693982017344 dimerization interface [polypeptide binding]; other site 693982017345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982017346 PAS domain; Region: PAS_9; pfam13426 693982017347 putative active site [active] 693982017348 heme pocket [chemical binding]; other site 693982017349 PAS domain S-box; Region: sensory_box; TIGR00229 693982017350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982017351 putative active site [active] 693982017352 heme pocket [chemical binding]; other site 693982017353 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693982017354 GAF domain; Region: GAF; pfam01590 693982017355 PAS fold; Region: PAS_4; pfam08448 693982017356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982017357 PAS fold; Region: PAS_3; pfam08447 693982017358 putative active site [active] 693982017359 heme pocket [chemical binding]; other site 693982017360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 693982017361 HWE histidine kinase; Region: HWE_HK; pfam07536 693982017362 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 693982017363 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 693982017364 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 693982017365 active site 693982017366 catalytic residues [active] 693982017367 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 693982017368 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693982017369 ligand binding site [chemical binding]; other site 693982017370 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 693982017371 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982017372 Walker A/P-loop; other site 693982017373 ATP binding site [chemical binding]; other site 693982017374 Q-loop/lid; other site 693982017375 ABC transporter signature motif; other site 693982017376 Walker B; other site 693982017377 D-loop; other site 693982017378 H-loop/switch region; other site 693982017379 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982017380 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982017381 TM-ABC transporter signature motif; other site 693982017382 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 693982017383 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 693982017384 protein binding site [polypeptide binding]; other site 693982017385 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 693982017386 Active site serine [active] 693982017387 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 693982017388 Peptidase family M50; Region: Peptidase_M50; pfam02163 693982017389 active site 693982017390 putative substrate binding region [chemical binding]; other site 693982017391 FOG: CBS domain [General function prediction only]; Region: COG0517 693982017392 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 693982017393 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 693982017394 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 693982017395 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982017396 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982017397 Walker A/P-loop; other site 693982017398 ATP binding site [chemical binding]; other site 693982017399 Q-loop/lid; other site 693982017400 ABC transporter signature motif; other site 693982017401 Walker B; other site 693982017402 D-loop; other site 693982017403 H-loop/switch region; other site 693982017404 TOBE domain; Region: TOBE_2; pfam08402 693982017405 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982017406 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693982017407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982017408 dimer interface [polypeptide binding]; other site 693982017409 conserved gate region; other site 693982017410 putative PBP binding loops; other site 693982017411 ABC-ATPase subunit interface; other site 693982017412 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982017413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982017414 dimer interface [polypeptide binding]; other site 693982017415 conserved gate region; other site 693982017416 putative PBP binding loops; other site 693982017417 ABC-ATPase subunit interface; other site 693982017418 Predicted transcriptional regulator [Transcription]; Region: COG4189 693982017419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982017420 putative DNA binding site [nucleotide binding]; other site 693982017421 dimerization interface [polypeptide binding]; other site 693982017422 putative Zn2+ binding site [ion binding]; other site 693982017423 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 693982017424 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 693982017425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 693982017426 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982017427 Homeodomain-like domain; Region: HTH_32; pfam13565 693982017428 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693982017429 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693982017430 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982017431 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982017432 DNA binding site [nucleotide binding] 693982017433 domain linker motif; other site 693982017434 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 693982017435 ligand binding site [chemical binding]; other site 693982017436 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982017437 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982017438 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693982017439 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 693982017440 DNA interaction; other site 693982017441 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982017442 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982017443 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982017444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982017445 dimer interface [polypeptide binding]; other site 693982017446 conserved gate region; other site 693982017447 putative PBP binding loops; other site 693982017448 ABC-ATPase subunit interface; other site 693982017449 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982017450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982017451 dimer interface [polypeptide binding]; other site 693982017452 conserved gate region; other site 693982017453 ABC-ATPase subunit interface; other site 693982017454 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982017455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982017456 Walker A/P-loop; other site 693982017457 ATP binding site [chemical binding]; other site 693982017458 Q-loop/lid; other site 693982017459 ABC transporter signature motif; other site 693982017460 Walker B; other site 693982017461 D-loop; other site 693982017462 H-loop/switch region; other site 693982017463 TOBE domain; Region: TOBE_2; pfam08402 693982017464 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982017465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982017466 DNA-binding site [nucleotide binding]; DNA binding site 693982017467 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982017468 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982017469 TM-ABC transporter signature motif; other site 693982017470 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982017471 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982017472 TM-ABC transporter signature motif; other site 693982017473 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982017474 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982017475 Walker A/P-loop; other site 693982017476 ATP binding site [chemical binding]; other site 693982017477 Q-loop/lid; other site 693982017478 ABC transporter signature motif; other site 693982017479 Walker B; other site 693982017480 D-loop; other site 693982017481 H-loop/switch region; other site 693982017482 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982017483 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982017484 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 693982017485 putative ligand binding site [chemical binding]; other site 693982017486 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 693982017487 glutathione synthetase; Provisional; Region: PRK12458 693982017488 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 693982017489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3930 693982017490 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 693982017491 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 693982017492 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 693982017493 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 693982017494 putative ADP-binding pocket [chemical binding]; other site 693982017495 Predicted membrane protein [Function unknown]; Region: COG1238 693982017496 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 693982017497 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 693982017498 DNA binding residues [nucleotide binding] 693982017499 dimer interface [polypeptide binding]; other site 693982017500 copper binding site [ion binding]; other site 693982017501 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 693982017502 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693982017503 metal-binding site [ion binding] 693982017504 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 693982017505 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693982017506 metal-binding site [ion binding] 693982017507 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693982017508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982017509 motif II; other site 693982017510 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982017511 dimerization interface [polypeptide binding]; other site 693982017512 putative DNA binding site [nucleotide binding]; other site 693982017513 putative Zn2+ binding site [ion binding]; other site 693982017514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693982017515 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 693982017516 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693982017517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 693982017518 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693982017519 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 693982017520 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 693982017521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982017522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982017523 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 693982017524 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 693982017525 putative active site [active] 693982017526 putative FMN binding site [chemical binding]; other site 693982017527 putative substrate binding site [chemical binding]; other site 693982017528 putative catalytic residue [active] 693982017529 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693982017530 Cupin domain; Region: Cupin_2; cl17218 693982017531 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 693982017532 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 693982017533 oligomerisation interface [polypeptide binding]; other site 693982017534 mobile loop; other site 693982017535 roof hairpin; other site 693982017536 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 693982017537 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 693982017538 ring oligomerisation interface [polypeptide binding]; other site 693982017539 ATP/Mg binding site [chemical binding]; other site 693982017540 stacking interactions; other site 693982017541 hinge regions; other site 693982017542 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 693982017543 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 693982017544 active site 693982017545 catalytic site [active] 693982017546 substrate binding site [chemical binding]; other site 693982017547 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 693982017548 dimer interface [polypeptide binding]; other site 693982017549 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982017550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982017551 active site 693982017552 phosphorylation site [posttranslational modification] 693982017553 intermolecular recognition site; other site 693982017554 dimerization interface [polypeptide binding]; other site 693982017555 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982017556 DNA binding site [nucleotide binding] 693982017557 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982017558 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693982017559 dimerization interface [polypeptide binding]; other site 693982017560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982017561 dimer interface [polypeptide binding]; other site 693982017562 phosphorylation site [posttranslational modification] 693982017563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982017564 ATP binding site [chemical binding]; other site 693982017565 G-X-G motif; other site 693982017566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982017567 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693982017568 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982017569 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693982017570 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982017571 catalytic loop [active] 693982017572 iron binding site [ion binding]; other site 693982017573 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693982017574 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 693982017575 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 693982017576 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693982017577 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693982017578 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982017579 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 693982017580 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 693982017581 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 693982017582 TrkA-N domain; Region: TrkA_N; pfam02254 693982017583 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 693982017584 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 693982017585 Sulphur transport; Region: Sulf_transp; pfam04143 693982017586 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 693982017587 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 693982017588 active site residue [active] 693982017589 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 693982017590 active site residue [active] 693982017591 Autotransporter beta-domain; Region: Autotransporter; pfam03797 693982017592 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 693982017593 Histidine kinase; Region: His_kinase; pfam06580 693982017594 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 693982017595 ATP binding site [chemical binding]; other site 693982017596 Mg2+ binding site [ion binding]; other site 693982017597 G-X-G motif; other site 693982017598 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 693982017599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982017600 active site 693982017601 phosphorylation site [posttranslational modification] 693982017602 intermolecular recognition site; other site 693982017603 dimerization interface [polypeptide binding]; other site 693982017604 LytTr DNA-binding domain; Region: LytTR; pfam04397 693982017605 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 693982017606 active site 693982017607 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 693982017608 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 693982017609 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693982017610 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 693982017611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982017612 dimer interface [polypeptide binding]; other site 693982017613 conserved gate region; other site 693982017614 putative PBP binding loops; other site 693982017615 ABC-ATPase subunit interface; other site 693982017616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982017617 dimer interface [polypeptide binding]; other site 693982017618 conserved gate region; other site 693982017619 putative PBP binding loops; other site 693982017620 ABC-ATPase subunit interface; other site 693982017621 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 693982017622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982017623 Walker A/P-loop; other site 693982017624 ATP binding site [chemical binding]; other site 693982017625 Q-loop/lid; other site 693982017626 ABC transporter signature motif; other site 693982017627 Walker B; other site 693982017628 D-loop; other site 693982017629 H-loop/switch region; other site 693982017630 TOBE domain; Region: TOBE_2; pfam08402 693982017631 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 693982017632 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693982017633 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 693982017634 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 693982017635 NAD(P) binding site [chemical binding]; other site 693982017636 catalytic residues [active] 693982017637 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 693982017638 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 693982017639 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 693982017640 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693982017641 catalytic residue [active] 693982017642 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 693982017643 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 693982017644 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 693982017645 PhoU domain; Region: PhoU; pfam01895 693982017646 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 693982017647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982017648 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693982017649 dimerization interface [polypeptide binding]; other site 693982017650 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982017651 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693982017652 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 693982017653 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 693982017654 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 693982017655 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693982017656 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693982017657 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982017658 DNA-binding site [nucleotide binding]; DNA binding site 693982017659 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693982017660 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 693982017661 Predicted membrane protein [Function unknown]; Region: COG2855 693982017662 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 693982017663 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693982017664 PYR/PP interface [polypeptide binding]; other site 693982017665 dimer interface [polypeptide binding]; other site 693982017666 TPP binding site [chemical binding]; other site 693982017667 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693982017668 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 693982017669 TPP-binding site; other site 693982017670 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693982017671 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982017672 SnoaL-like domain; Region: SnoaL_2; pfam12680 693982017673 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693982017674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982017675 dimer interface [polypeptide binding]; other site 693982017676 conserved gate region; other site 693982017677 putative PBP binding loops; other site 693982017678 ABC-ATPase subunit interface; other site 693982017679 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 693982017680 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693982017681 Walker A/P-loop; other site 693982017682 ATP binding site [chemical binding]; other site 693982017683 Q-loop/lid; other site 693982017684 ABC transporter signature motif; other site 693982017685 Walker B; other site 693982017686 D-loop; other site 693982017687 H-loop/switch region; other site 693982017688 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 693982017689 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982017690 substrate binding pocket [chemical binding]; other site 693982017691 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 693982017692 membrane-bound complex binding site; other site 693982017693 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693982017694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982017695 DNA-binding site [nucleotide binding]; DNA binding site 693982017696 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693982017697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982017698 homodimer interface [polypeptide binding]; other site 693982017699 catalytic residue [active] 693982017700 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 693982017701 NmrA-like family; Region: NmrA; pfam05368 693982017702 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 693982017703 NADP binding site [chemical binding]; other site 693982017704 active site 693982017705 regulatory binding site [polypeptide binding]; other site 693982017706 Predicted transcriptional regulators [Transcription]; Region: COG1733 693982017707 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 693982017708 AAA domain; Region: AAA_17; pfam13207 693982017709 AAA domain; Region: AAA_18; pfam13238 693982017710 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 693982017711 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 693982017712 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 693982017713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 693982017714 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693982017715 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 693982017716 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982017717 putative ligand binding site [chemical binding]; other site 693982017718 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982017719 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982017720 Walker A/P-loop; other site 693982017721 ATP binding site [chemical binding]; other site 693982017722 Q-loop/lid; other site 693982017723 ABC transporter signature motif; other site 693982017724 Walker B; other site 693982017725 D-loop; other site 693982017726 H-loop/switch region; other site 693982017727 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982017728 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982017729 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982017730 TM-ABC transporter signature motif; other site 693982017731 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693982017732 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 693982017733 substrate binding site [chemical binding]; other site 693982017734 ATP binding site [chemical binding]; other site 693982017735 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 693982017736 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982017737 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982017738 DNA binding site [nucleotide binding] 693982017739 domain linker motif; other site 693982017740 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693982017741 dimerization interface [polypeptide binding]; other site 693982017742 ligand binding site [chemical binding]; other site 693982017743 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 693982017744 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 693982017745 D-pathway; other site 693982017746 Putative ubiquinol binding site [chemical binding]; other site 693982017747 Low-spin heme (heme b) binding site [chemical binding]; other site 693982017748 Putative water exit pathway; other site 693982017749 Binuclear center (heme o3/CuB) [ion binding]; other site 693982017750 K-pathway; other site 693982017751 Putative proton exit pathway; other site 693982017752 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 693982017753 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693982017754 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693982017755 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 693982017756 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 693982017757 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 693982017758 Cytochrome c; Region: Cytochrom_C; pfam00034 693982017759 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693982017760 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693982017761 Cytochrome c553 [Energy production and conversion]; Region: COG2863 693982017762 Cytochrome c; Region: Cytochrom_C; cl11414 693982017763 Predicted membrane protein [Function unknown]; Region: COG3336 693982017764 Predicted membrane protein [Function unknown]; Region: COG4244 693982017765 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 693982017766 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 693982017767 Predicted membrane protein [Function unknown]; Region: COG2323 693982017768 LysR family transcriptional regulator; Provisional; Region: PRK14997 693982017769 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982017770 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 693982017771 putative effector binding pocket; other site 693982017772 putative dimerization interface [polypeptide binding]; other site 693982017773 Isochorismatase family; Region: Isochorismatase; pfam00857 693982017774 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 693982017775 catalytic triad [active] 693982017776 dimer interface [polypeptide binding]; other site 693982017777 conserved cis-peptide bond; other site 693982017778 Predicted membrane protein [Function unknown]; Region: COG4244 693982017779 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 693982017780 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982017781 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982017782 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982017783 glucuronate isomerase; Reviewed; Region: PRK02925 693982017784 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 693982017785 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693982017786 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 693982017787 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693982017788 DctM-like transporters; Region: DctM; pfam06808 693982017789 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693982017790 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982017791 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982017792 DNA-binding site [nucleotide binding]; DNA binding site 693982017793 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693982017794 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 693982017795 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 693982017796 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 693982017797 NADP binding site [chemical binding]; other site 693982017798 homodimer interface [polypeptide binding]; other site 693982017799 active site 693982017800 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 693982017801 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982017802 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982017803 DNA binding site [nucleotide binding] 693982017804 domain linker motif; other site 693982017805 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 693982017806 putative dimerization interface [polypeptide binding]; other site 693982017807 putative ligand binding site [chemical binding]; other site 693982017808 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982017809 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 693982017810 putative ligand binding site [chemical binding]; other site 693982017811 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982017812 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982017813 Walker A/P-loop; other site 693982017814 ATP binding site [chemical binding]; other site 693982017815 Q-loop/lid; other site 693982017816 ABC transporter signature motif; other site 693982017817 Walker B; other site 693982017818 D-loop; other site 693982017819 H-loop/switch region; other site 693982017820 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982017821 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982017822 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982017823 TM-ABC transporter signature motif; other site 693982017824 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982017825 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982017826 TM-ABC transporter signature motif; other site 693982017827 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 693982017828 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693982017829 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693982017830 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982017831 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 693982017832 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 693982017833 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693982017834 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 693982017835 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693982017836 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693982017837 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982017838 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693982017839 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693982017840 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 693982017841 BON domain; Region: BON; cl02771 693982017842 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 693982017843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 693982017844 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 693982017845 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 693982017846 NADP binding site [chemical binding]; other site 693982017847 active site 693982017848 putative substrate binding site [chemical binding]; other site 693982017849 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 693982017850 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 693982017851 NAD binding site [chemical binding]; other site 693982017852 substrate binding site [chemical binding]; other site 693982017853 homodimer interface [polypeptide binding]; other site 693982017854 active site 693982017855 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 693982017856 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 693982017857 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 693982017858 substrate binding site; other site 693982017859 tetramer interface; other site 693982017860 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 693982017861 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 693982017862 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 693982017863 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 693982017864 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693982017865 active site 693982017866 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982017867 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 693982017868 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982017869 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 693982017870 putative ADP-binding pocket [chemical binding]; other site 693982017871 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693982017872 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 693982017873 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 693982017874 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693982017875 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 693982017876 Walker A/P-loop; other site 693982017877 ATP binding site [chemical binding]; other site 693982017878 Q-loop/lid; other site 693982017879 ABC transporter signature motif; other site 693982017880 Walker B; other site 693982017881 D-loop; other site 693982017882 H-loop/switch region; other site 693982017883 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 693982017884 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 693982017885 lipoyl-biotinyl attachment site [posttranslational modification]; other site 693982017886 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982017887 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 693982017888 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 693982017889 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 693982017890 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693982017891 active site 693982017892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982017893 S-adenosylmethionine binding site [chemical binding]; other site 693982017894 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982017895 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 693982017896 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982017897 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 693982017898 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982017899 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 693982017900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693982017901 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 693982017902 motif I; other site 693982017903 active site 693982017904 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 693982017905 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693982017906 active site 693982017907 metal binding site [ion binding]; metal-binding site 693982017908 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 693982017909 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 693982017910 Sulfatase; Region: Sulfatase; pfam00884 693982017911 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693982017912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982017913 active site 693982017914 phosphorylation site [posttranslational modification] 693982017915 intermolecular recognition site; other site 693982017916 dimerization interface [polypeptide binding]; other site 693982017917 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693982017918 DNA binding site [nucleotide binding] 693982017919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693982017920 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982017921 dimer interface [polypeptide binding]; other site 693982017922 phosphorylation site [posttranslational modification] 693982017923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982017924 ATP binding site [chemical binding]; other site 693982017925 Mg2+ binding site [ion binding]; other site 693982017926 G-X-G motif; other site 693982017927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982017928 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 693982017929 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 693982017930 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982017931 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982017932 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693982017933 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693982017934 Walker A/P-loop; other site 693982017935 ATP binding site [chemical binding]; other site 693982017936 Q-loop/lid; other site 693982017937 ABC transporter signature motif; other site 693982017938 Walker B; other site 693982017939 D-loop; other site 693982017940 H-loop/switch region; other site 693982017941 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 693982017942 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693982017943 Walker A/P-loop; other site 693982017944 ATP binding site [chemical binding]; other site 693982017945 Q-loop/lid; other site 693982017946 ABC transporter signature motif; other site 693982017947 Walker B; other site 693982017948 D-loop; other site 693982017949 H-loop/switch region; other site 693982017950 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693982017951 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 693982017952 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693982017953 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 693982017954 Predicted esterase [General function prediction only]; Region: COG0400 693982017955 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 693982017956 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982017957 Zn binding site [ion binding]; other site 693982017958 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 693982017959 Zn binding site [ion binding]; other site 693982017960 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 693982017961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693982017962 dimer interface [polypeptide binding]; other site 693982017963 phosphorylation site [posttranslational modification] 693982017964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982017965 ATP binding site [chemical binding]; other site 693982017966 Mg2+ binding site [ion binding]; other site 693982017967 G-X-G motif; other site 693982017968 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693982017969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982017970 active site 693982017971 phosphorylation site [posttranslational modification] 693982017972 intermolecular recognition site; other site 693982017973 dimerization interface [polypeptide binding]; other site 693982017974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982017975 Walker A motif; other site 693982017976 ATP binding site [chemical binding]; other site 693982017977 Walker B motif; other site 693982017978 arginine finger; other site 693982017979 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693982017980 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 693982017981 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982017982 Walker A/P-loop; other site 693982017983 ATP binding site [chemical binding]; other site 693982017984 Q-loop/lid; other site 693982017985 ABC transporter signature motif; other site 693982017986 Walker B; other site 693982017987 D-loop; other site 693982017988 H-loop/switch region; other site 693982017989 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 693982017990 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982017991 Walker A/P-loop; other site 693982017992 ATP binding site [chemical binding]; other site 693982017993 Q-loop/lid; other site 693982017994 ABC transporter signature motif; other site 693982017995 Walker B; other site 693982017996 D-loop; other site 693982017997 H-loop/switch region; other site 693982017998 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982017999 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 693982018000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018001 dimer interface [polypeptide binding]; other site 693982018002 conserved gate region; other site 693982018003 ABC-ATPase subunit interface; other site 693982018004 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 693982018005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018006 dimer interface [polypeptide binding]; other site 693982018007 conserved gate region; other site 693982018008 putative PBP binding loops; other site 693982018009 ABC-ATPase subunit interface; other site 693982018010 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 693982018011 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 693982018012 peptide binding site [polypeptide binding]; other site 693982018013 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 693982018014 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 693982018015 intersubunit interface [polypeptide binding]; other site 693982018016 active site 693982018017 zinc binding site [ion binding]; other site 693982018018 Na+ binding site [ion binding]; other site 693982018019 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693982018020 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 693982018021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982018022 Walker A/P-loop; other site 693982018023 ATP binding site [chemical binding]; other site 693982018024 Q-loop/lid; other site 693982018025 ABC transporter signature motif; other site 693982018026 Walker B; other site 693982018027 D-loop; other site 693982018028 H-loop/switch region; other site 693982018029 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 693982018030 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 693982018031 active site 693982018032 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 693982018033 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693982018034 active site 693982018035 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 693982018036 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 693982018037 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 693982018038 DNA binding residues [nucleotide binding] 693982018039 dimer interface [polypeptide binding]; other site 693982018040 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 693982018041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982018042 non-specific DNA binding site [nucleotide binding]; other site 693982018043 salt bridge; other site 693982018044 sequence-specific DNA binding site [nucleotide binding]; other site 693982018045 Cupin domain; Region: Cupin_2; pfam07883 693982018046 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 693982018047 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693982018048 inhibitor-cofactor binding pocket; inhibition site 693982018049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982018050 catalytic residue [active] 693982018051 succinic semialdehyde dehydrogenase; Region: PLN02278 693982018052 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 693982018053 tetramerization interface [polypeptide binding]; other site 693982018054 NAD(P) binding site [chemical binding]; other site 693982018055 catalytic residues [active] 693982018056 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 693982018057 propionate/acetate kinase; Provisional; Region: PRK12379 693982018058 heat shock protein 90; Provisional; Region: PRK05218 693982018059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693982018060 ATP binding site [chemical binding]; other site 693982018061 Mg2+ binding site [ion binding]; other site 693982018062 G-X-G motif; other site 693982018063 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 693982018064 CoA-transferase family III; Region: CoA_transf_3; pfam02515 693982018065 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 693982018066 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693982018067 FAD binding site [chemical binding]; other site 693982018068 substrate binding pocket [chemical binding]; other site 693982018069 catalytic base [active] 693982018070 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982018071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982018072 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693982018073 dimerization interface [polypeptide binding]; other site 693982018074 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693982018075 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693982018076 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 693982018077 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 693982018078 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 693982018079 Walker A/P-loop; other site 693982018080 ATP binding site [chemical binding]; other site 693982018081 Q-loop/lid; other site 693982018082 ABC transporter signature motif; other site 693982018083 Walker B; other site 693982018084 D-loop; other site 693982018085 H-loop/switch region; other site 693982018086 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 693982018087 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 693982018088 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 693982018089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018090 dimer interface [polypeptide binding]; other site 693982018091 conserved gate region; other site 693982018092 ABC-ATPase subunit interface; other site 693982018093 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 693982018094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018095 dimer interface [polypeptide binding]; other site 693982018096 conserved gate region; other site 693982018097 ABC-ATPase subunit interface; other site 693982018098 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 693982018099 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 693982018100 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693982018101 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 693982018102 active site 693982018103 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 693982018104 active site 693982018105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982018106 putative DNA binding site [nucleotide binding]; other site 693982018107 putative Zn2+ binding site [ion binding]; other site 693982018108 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693982018109 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 693982018110 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 693982018111 putative active site [active] 693982018112 putative NTP binding site [chemical binding]; other site 693982018113 putative nucleic acid binding site [nucleotide binding]; other site 693982018114 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 693982018115 imidazolonepropionase; Validated; Region: PRK09356 693982018116 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 693982018117 active site 693982018118 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 693982018119 active sites [active] 693982018120 tetramer interface [polypeptide binding]; other site 693982018121 N-formylglutamate amidohydrolase; Region: FGase; cl01522 693982018122 urocanate hydratase; Provisional; Region: PRK05414 693982018123 sugar efflux transporter; Region: 2A0120; TIGR00899 693982018124 Uncharacterized conserved protein [Function unknown]; Region: COG5476 693982018125 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 693982018126 MlrC C-terminus; Region: MlrC_C; pfam07171 693982018127 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 693982018128 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 693982018129 active site 693982018130 short chain dehydrogenase; Provisional; Region: PRK07074 693982018131 classical (c) SDRs; Region: SDR_c; cd05233 693982018132 NAD(P) binding site [chemical binding]; other site 693982018133 active site 693982018134 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693982018135 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693982018136 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693982018137 putative active site [active] 693982018138 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693982018139 homotrimer interaction site [polypeptide binding]; other site 693982018140 putative active site [active] 693982018141 Uncharacterized conserved protein [Function unknown]; Region: COG5476 693982018142 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 693982018143 MlrC C-terminus; Region: MlrC_C; pfam07171 693982018144 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 693982018145 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693982018146 active site 693982018147 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 693982018148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982018149 Coenzyme A binding pocket [chemical binding]; other site 693982018150 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 693982018151 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982018152 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982018153 Walker A/P-loop; other site 693982018154 ATP binding site [chemical binding]; other site 693982018155 Q-loop/lid; other site 693982018156 ABC transporter signature motif; other site 693982018157 Walker B; other site 693982018158 D-loop; other site 693982018159 H-loop/switch region; other site 693982018160 TOBE domain; Region: TOBE_2; pfam08402 693982018161 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982018162 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693982018163 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982018164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018165 dimer interface [polypeptide binding]; other site 693982018166 conserved gate region; other site 693982018167 putative PBP binding loops; other site 693982018168 ABC-ATPase subunit interface; other site 693982018169 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982018170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018171 dimer interface [polypeptide binding]; other site 693982018172 conserved gate region; other site 693982018173 putative PBP binding loops; other site 693982018174 ABC-ATPase subunit interface; other site 693982018175 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982018176 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982018177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018178 dimer interface [polypeptide binding]; other site 693982018179 conserved gate region; other site 693982018180 putative PBP binding loops; other site 693982018181 ABC-ATPase subunit interface; other site 693982018182 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 693982018183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982018184 Walker A/P-loop; other site 693982018185 ATP binding site [chemical binding]; other site 693982018186 Q-loop/lid; other site 693982018187 ABC transporter signature motif; other site 693982018188 Walker B; other site 693982018189 D-loop; other site 693982018190 H-loop/switch region; other site 693982018191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018192 dimer interface [polypeptide binding]; other site 693982018193 conserved gate region; other site 693982018194 ABC-ATPase subunit interface; other site 693982018195 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 693982018196 mercuric reductase; Validated; Region: PRK06370 693982018197 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693982018198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982018199 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693982018200 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 693982018201 Amidinotransferase; Region: Amidinotransf; cl12043 693982018202 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 693982018203 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 693982018204 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693982018205 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693982018206 NAD(P) binding site [chemical binding]; other site 693982018207 catalytic residues [active] 693982018208 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693982018209 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 693982018210 NAD(P) binding site [chemical binding]; other site 693982018211 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 693982018212 intersubunit interface [polypeptide binding]; other site 693982018213 active site 693982018214 catalytic residue [active] 693982018215 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693982018216 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 693982018217 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693982018218 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 693982018219 putative binding site; other site 693982018220 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 693982018221 MG2 domain; Region: A2M_N; pfam01835 693982018222 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 693982018223 surface patch; other site 693982018224 thioester region; other site 693982018225 specificity defining residues; other site 693982018226 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 693982018227 Transglycosylase; Region: Transgly; pfam00912 693982018228 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693982018229 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 693982018230 Protein of unknown function (DUF982); Region: DUF982; pfam06169 693982018231 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 693982018232 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 693982018233 putative dimer interface [polypeptide binding]; other site 693982018234 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 693982018235 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 693982018236 putative dimer interface [polypeptide binding]; other site 693982018237 guanine deaminase; Provisional; Region: PRK09228 693982018238 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 693982018239 active site 693982018240 Predicted membrane protein [Function unknown]; Region: COG3748 693982018241 Protein of unknown function (DUF989); Region: DUF989; pfam06181 693982018242 Cytochrome c; Region: Cytochrom_C; pfam00034 693982018243 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982018244 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982018245 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693982018246 putative effector binding pocket; other site 693982018247 dimerization interface [polypeptide binding]; other site 693982018248 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 693982018249 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693982018250 NAD(P) binding site [chemical binding]; other site 693982018251 Predicted transcriptional regulators [Transcription]; Region: COG1733 693982018252 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 693982018253 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 693982018254 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 693982018255 XdhC Rossmann domain; Region: XdhC_C; pfam13478 693982018256 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 693982018257 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693982018258 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693982018259 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 693982018260 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693982018261 catalytic loop [active] 693982018262 iron binding site [ion binding]; other site 693982018263 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693982018264 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 693982018265 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 693982018266 active site 693982018267 homotetramer interface [polypeptide binding]; other site 693982018268 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 693982018269 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 693982018270 active site 693982018271 catalytic site [active] 693982018272 tetramer interface [polypeptide binding]; other site 693982018273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 693982018274 Allantoicase [Nucleotide transport and metabolism]; Region: Alc; COG4266 693982018275 Allantoicase repeat; Region: Allantoicase; pfam03561 693982018276 Allantoicase repeat; Region: Allantoicase; pfam03561 693982018277 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 693982018278 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 693982018279 phosphoribosyltransferase; Provisional; Region: PRK06031 693982018280 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693982018281 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 693982018282 metal binding site [ion binding]; metal-binding site 693982018283 putative dimer interface [polypeptide binding]; other site 693982018284 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 693982018285 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693982018286 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 693982018287 active site 693982018288 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 693982018289 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 693982018290 active site 693982018291 tetramer interface [polypeptide binding]; other site 693982018292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982018293 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 693982018294 Walker A/P-loop; other site 693982018295 ATP binding site [chemical binding]; other site 693982018296 Q-loop/lid; other site 693982018297 ABC transporter signature motif; other site 693982018298 Walker B; other site 693982018299 D-loop; other site 693982018300 H-loop/switch region; other site 693982018301 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693982018302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018303 dimer interface [polypeptide binding]; other site 693982018304 conserved gate region; other site 693982018305 putative PBP binding loops; other site 693982018306 ABC-ATPase subunit interface; other site 693982018307 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 693982018308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018309 dimer interface [polypeptide binding]; other site 693982018310 conserved gate region; other site 693982018311 putative PBP binding loops; other site 693982018312 ABC-ATPase subunit interface; other site 693982018313 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 693982018314 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693982018315 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982018316 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982018317 DNA binding site [nucleotide binding] 693982018318 domain linker motif; other site 693982018319 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693982018320 dimerization interface [polypeptide binding]; other site 693982018321 ligand binding site [chemical binding]; other site 693982018322 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 693982018323 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693982018324 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693982018325 ligand binding site [chemical binding]; other site 693982018326 flexible hinge region; other site 693982018327 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693982018328 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693982018329 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 693982018330 Walker A/P-loop; other site 693982018331 ATP binding site [chemical binding]; other site 693982018332 Q-loop/lid; other site 693982018333 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693982018334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982018335 ABC transporter signature motif; other site 693982018336 Walker B; other site 693982018337 D-loop; other site 693982018338 H-loop/switch region; other site 693982018339 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 693982018340 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693982018341 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 693982018342 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982018343 putative ADP-binding pocket [chemical binding]; other site 693982018344 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 693982018345 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 693982018346 microcin C ABC transporter permease; Provisional; Region: PRK15021 693982018347 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 693982018348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018349 dimer interface [polypeptide binding]; other site 693982018350 conserved gate region; other site 693982018351 putative PBP binding loops; other site 693982018352 ABC-ATPase subunit interface; other site 693982018353 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982018354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018355 dimer interface [polypeptide binding]; other site 693982018356 conserved gate region; other site 693982018357 putative PBP binding loops; other site 693982018358 ABC-ATPase subunit interface; other site 693982018359 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 693982018360 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 693982018361 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 693982018362 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982018363 Walker A/P-loop; other site 693982018364 ATP binding site [chemical binding]; other site 693982018365 Q-loop/lid; other site 693982018366 ABC transporter signature motif; other site 693982018367 Walker B; other site 693982018368 D-loop; other site 693982018369 H-loop/switch region; other site 693982018370 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982018371 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982018372 Walker A/P-loop; other site 693982018373 ATP binding site [chemical binding]; other site 693982018374 Q-loop/lid; other site 693982018375 ABC transporter signature motif; other site 693982018376 Walker B; other site 693982018377 D-loop; other site 693982018378 H-loop/switch region; other site 693982018379 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982018380 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 693982018381 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982018382 cyclase homology domain; Region: CHD; cd07302 693982018383 nucleotidyl binding site; other site 693982018384 metal binding site [ion binding]; metal-binding site 693982018385 dimer interface [polypeptide binding]; other site 693982018386 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 693982018387 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693982018388 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 693982018389 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 693982018390 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 693982018391 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 693982018392 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 693982018393 NodB motif; other site 693982018394 putative active site [active] 693982018395 putative catalytic site [active] 693982018396 putative Zn binding site [ion binding]; other site 693982018397 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982018398 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 693982018399 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693982018400 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693982018401 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982018402 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 693982018403 putative ADP-binding pocket [chemical binding]; other site 693982018404 sulfotransferase; Region: PLN02164 693982018405 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 693982018406 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 693982018407 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693982018408 inhibitor-cofactor binding pocket; inhibition site 693982018409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982018410 catalytic residue [active] 693982018411 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 693982018412 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 693982018413 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 693982018414 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 693982018415 SLBB domain; Region: SLBB; pfam10531 693982018416 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 693982018417 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693982018418 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 693982018419 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 693982018420 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 693982018421 Chain length determinant protein; Region: Wzz; pfam02706 693982018422 Chain length determinant protein; Region: Wzz; cl15801 693982018423 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 693982018424 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 693982018425 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 693982018426 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651 693982018427 putative active site [active] 693982018428 putative substrate binding site [chemical binding]; other site 693982018429 putative cosubstrate binding site; other site 693982018430 catalytic site [active] 693982018431 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 693982018432 active site 693982018433 hexamer interface [polypeptide binding]; other site 693982018434 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 693982018435 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 693982018436 NAD(P) binding site [chemical binding]; other site 693982018437 homodimer interface [polypeptide binding]; other site 693982018438 substrate binding site [chemical binding]; other site 693982018439 active site 693982018440 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 693982018441 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982018442 putative ADP-binding pocket [chemical binding]; other site 693982018443 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 693982018444 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 693982018445 putative ADP-binding pocket [chemical binding]; other site 693982018446 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 693982018447 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982018448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982018449 NAD(P) binding site [chemical binding]; other site 693982018450 active site 693982018451 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 693982018452 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 693982018453 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 693982018454 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 693982018455 active site 693982018456 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693982018457 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 693982018458 active site 693982018459 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 693982018460 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 693982018461 CysD dimerization site [polypeptide binding]; other site 693982018462 G1 box; other site 693982018463 putative GEF interaction site [polypeptide binding]; other site 693982018464 GTP/Mg2+ binding site [chemical binding]; other site 693982018465 Switch I region; other site 693982018466 G2 box; other site 693982018467 G3 box; other site 693982018468 Switch II region; other site 693982018469 G4 box; other site 693982018470 G5 box; other site 693982018471 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 693982018472 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 693982018473 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 693982018474 ligand-binding site [chemical binding]; other site 693982018475 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 693982018476 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693982018477 Active Sites [active] 693982018478 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693982018479 non-specific DNA interactions [nucleotide binding]; other site 693982018480 DNA binding site [nucleotide binding] 693982018481 sequence specific DNA binding site [nucleotide binding]; other site 693982018482 putative cAMP binding site [chemical binding]; other site 693982018483 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693982018484 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693982018485 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982018486 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982018487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018488 dimer interface [polypeptide binding]; other site 693982018489 conserved gate region; other site 693982018490 putative PBP binding loops; other site 693982018491 ABC-ATPase subunit interface; other site 693982018492 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982018493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018494 dimer interface [polypeptide binding]; other site 693982018495 conserved gate region; other site 693982018496 putative PBP binding loops; other site 693982018497 ABC-ATPase subunit interface; other site 693982018498 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 693982018499 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 693982018500 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 693982018501 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693982018502 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 693982018503 substrate binding site [chemical binding]; other site 693982018504 ATP binding site [chemical binding]; other site 693982018505 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982018506 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982018507 Walker A/P-loop; other site 693982018508 ATP binding site [chemical binding]; other site 693982018509 Q-loop/lid; other site 693982018510 ABC transporter signature motif; other site 693982018511 Walker B; other site 693982018512 D-loop; other site 693982018513 H-loop/switch region; other site 693982018514 TOBE domain; Region: TOBE_2; pfam08402 693982018515 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693982018516 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 693982018517 Bacterial transcriptional regulator; Region: IclR; pfam01614 693982018518 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693982018519 homotrimer interaction site [polypeptide binding]; other site 693982018520 putative active site [active] 693982018521 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693982018522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982018523 Walker A/P-loop; other site 693982018524 ATP binding site [chemical binding]; other site 693982018525 Q-loop/lid; other site 693982018526 ABC transporter signature motif; other site 693982018527 Walker B; other site 693982018528 D-loop; other site 693982018529 H-loop/switch region; other site 693982018530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018531 dimer interface [polypeptide binding]; other site 693982018532 conserved gate region; other site 693982018533 putative PBP binding loops; other site 693982018534 ABC-ATPase subunit interface; other site 693982018535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018536 dimer interface [polypeptide binding]; other site 693982018537 conserved gate region; other site 693982018538 putative PBP binding loops; other site 693982018539 ABC-ATPase subunit interface; other site 693982018540 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693982018541 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982018542 substrate binding pocket [chemical binding]; other site 693982018543 membrane-bound complex binding site; other site 693982018544 hinge residues; other site 693982018545 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 693982018546 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 693982018547 dimer interface [polypeptide binding]; other site 693982018548 active site 693982018549 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693982018550 substrate binding site [chemical binding]; other site 693982018551 catalytic residue [active] 693982018552 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 693982018553 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693982018554 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693982018555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018556 dimer interface [polypeptide binding]; other site 693982018557 conserved gate region; other site 693982018558 putative PBP binding loops; other site 693982018559 ABC-ATPase subunit interface; other site 693982018560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018561 dimer interface [polypeptide binding]; other site 693982018562 conserved gate region; other site 693982018563 putative PBP binding loops; other site 693982018564 ABC-ATPase subunit interface; other site 693982018565 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 693982018566 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 693982018567 Walker A/P-loop; other site 693982018568 ATP binding site [chemical binding]; other site 693982018569 Q-loop/lid; other site 693982018570 ABC transporter signature motif; other site 693982018571 Walker B; other site 693982018572 D-loop; other site 693982018573 H-loop/switch region; other site 693982018574 TOBE-like domain; Region: TOBE_3; pfam12857 693982018575 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693982018576 FAD binding domain; Region: FAD_binding_4; pfam01565 693982018577 Uncharacterized conserved protein [Function unknown]; Region: COG5654 693982018578 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 693982018579 enoyl-CoA hydratase; Provisional; Region: PRK07468 693982018580 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693982018581 substrate binding site [chemical binding]; other site 693982018582 oxyanion hole (OAH) forming residues; other site 693982018583 trimer interface [polypeptide binding]; other site 693982018584 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 693982018585 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 693982018586 active site 693982018587 catalytic residues [active] 693982018588 metal binding site [ion binding]; metal-binding site 693982018589 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 693982018590 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693982018591 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693982018592 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693982018593 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693982018594 carboxyltransferase (CT) interaction site; other site 693982018595 biotinylation site [posttranslational modification]; other site 693982018596 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693982018597 homotrimer interaction site [polypeptide binding]; other site 693982018598 putative active site [active] 693982018599 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 693982018600 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 693982018601 isovaleryl-CoA dehydrogenase; Region: PLN02519 693982018602 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693982018603 active site 693982018604 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 693982018605 Shikimate kinase; Region: SKI; pfam01202 693982018606 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982018607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982018608 non-specific DNA binding site [nucleotide binding]; other site 693982018609 salt bridge; other site 693982018610 sequence-specific DNA binding site [nucleotide binding]; other site 693982018611 Uncharacterized conserved protein [Function unknown]; Region: COG3482 693982018612 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 693982018613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982018614 active site 693982018615 phosphorylation site [posttranslational modification] 693982018616 intermolecular recognition site; other site 693982018617 ANTAR domain; Region: ANTAR; pfam03861 693982018618 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 693982018619 NMT1-like family; Region: NMT1_2; pfam13379 693982018620 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 693982018621 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 693982018622 putative active site pocket [active] 693982018623 metal binding site [ion binding]; metal-binding site 693982018624 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 693982018625 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693982018626 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693982018627 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 693982018628 NAD binding site [chemical binding]; other site 693982018629 homotetramer interface [polypeptide binding]; other site 693982018630 homodimer interface [polypeptide binding]; other site 693982018631 active site 693982018632 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 693982018633 active site 2 [active] 693982018634 active site 1 [active] 693982018635 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982018636 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982018637 Uncharacterized conserved protein [Function unknown]; Region: COG3254 693982018638 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 693982018639 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 693982018640 active site pocket [active] 693982018641 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693982018642 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693982018643 Walker A/P-loop; other site 693982018644 ATP binding site [chemical binding]; other site 693982018645 Q-loop/lid; other site 693982018646 ABC transporter signature motif; other site 693982018647 Walker B; other site 693982018648 D-loop; other site 693982018649 H-loop/switch region; other site 693982018650 TOBE domain; Region: TOBE_2; pfam08402 693982018651 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693982018652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018653 dimer interface [polypeptide binding]; other site 693982018654 conserved gate region; other site 693982018655 putative PBP binding loops; other site 693982018656 ABC-ATPase subunit interface; other site 693982018657 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693982018658 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693982018659 putative DNA binding site [nucleotide binding]; other site 693982018660 putative Zn2+ binding site [ion binding]; other site 693982018661 Bacterial transcriptional regulator; Region: IclR; pfam01614 693982018662 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 693982018663 Amidohydrolase; Region: Amidohydro_2; pfam04909 693982018664 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 693982018665 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 693982018666 active site 693982018667 catalytic site [active] 693982018668 Zn binding site [ion binding]; other site 693982018669 tetramer interface [polypeptide binding]; other site 693982018670 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 693982018671 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693982018672 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982018673 substrate binding pocket [chemical binding]; other site 693982018674 membrane-bound complex binding site; other site 693982018675 hinge residues; other site 693982018676 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693982018677 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693982018678 Walker A/P-loop; other site 693982018679 ATP binding site [chemical binding]; other site 693982018680 Q-loop/lid; other site 693982018681 ABC transporter signature motif; other site 693982018682 Walker B; other site 693982018683 D-loop; other site 693982018684 H-loop/switch region; other site 693982018685 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693982018686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018687 dimer interface [polypeptide binding]; other site 693982018688 conserved gate region; other site 693982018689 putative PBP binding loops; other site 693982018690 ABC-ATPase subunit interface; other site 693982018691 argininosuccinate lyase; Provisional; Region: PRK00855 693982018692 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 693982018693 active sites [active] 693982018694 tetramer interface [polypeptide binding]; other site 693982018695 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693982018696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982018697 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693982018698 dimerization interface [polypeptide binding]; other site 693982018699 substrate binding pocket [chemical binding]; other site 693982018700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982018701 Coenzyme A binding pocket [chemical binding]; other site 693982018702 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 693982018703 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 693982018704 active site 693982018705 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982018706 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 693982018707 CoA-transferase family III; Region: CoA_transf_3; pfam02515 693982018708 TraC-like protein; Region: TraC; pfam07820 693982018709 Conjugal transfer protein TraD; Region: TraD; pfam06412 693982018710 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693982018711 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982018712 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 693982018713 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693982018714 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693982018715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982018716 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693982018717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693982018718 Transposase; Region: HTH_Tnp_1; pfam01527 693982018719 acyl carrier protein; Provisional; Region: acpP; PRK00982 693982018720 GXWXG protein; Region: GXWXG; pfam14231 693982018721 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 693982018722 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693982018723 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 693982018724 catalytic residues [active] 693982018725 catalytic nucleophile [active] 693982018726 Recombinase; Region: Recombinase; pfam07508 693982018727 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693982018728 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982018729 Winged helix-turn helix; Region: HTH_29; pfam13551 693982018730 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693982018731 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 693982018732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982018733 Walker A motif; other site 693982018734 ATP binding site [chemical binding]; other site 693982018735 Walker B motif; other site 693982018736 Staphylococcal nuclease homologues; Region: SNc; smart00318 693982018737 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 693982018738 Catalytic site; other site 693982018739 Hint domain; Region: Hint_2; pfam13403 693982018740 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 693982018741 active site 693982018742 DNA binding site [nucleotide binding] 693982018743 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 693982018744 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 693982018745 DNA binding site [nucleotide binding] 693982018746 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 693982018747 nucleotide binding site [chemical binding]; other site 693982018748 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 693982018749 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 693982018750 metal binding site [ion binding]; metal-binding site 693982018751 dimer interface [polypeptide binding]; other site 693982018752 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 693982018753 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 693982018754 putative active site [active] 693982018755 putative metal binding site [ion binding]; other site 693982018756 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 693982018757 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982018758 Walker A/P-loop; other site 693982018759 ATP binding site [chemical binding]; other site 693982018760 Q-loop/lid; other site 693982018761 ABC transporter signature motif; other site 693982018762 Walker B; other site 693982018763 D-loop; other site 693982018764 H-loop/switch region; other site 693982018765 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982018766 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982018767 Walker A/P-loop; other site 693982018768 ATP binding site [chemical binding]; other site 693982018769 Q-loop/lid; other site 693982018770 ABC transporter signature motif; other site 693982018771 Walker B; other site 693982018772 D-loop; other site 693982018773 H-loop/switch region; other site 693982018774 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982018775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018776 dimer interface [polypeptide binding]; other site 693982018777 conserved gate region; other site 693982018778 putative PBP binding loops; other site 693982018779 ABC-ATPase subunit interface; other site 693982018780 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982018781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982018782 dimer interface [polypeptide binding]; other site 693982018783 conserved gate region; other site 693982018784 putative PBP binding loops; other site 693982018785 ABC-ATPase subunit interface; other site 693982018786 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982018787 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 693982018788 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693982018789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982018790 non-specific DNA binding site [nucleotide binding]; other site 693982018791 salt bridge; other site 693982018792 sequence-specific DNA binding site [nucleotide binding]; other site 693982018793 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 693982018794 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 693982018795 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 693982018796 putative N- and C-terminal domain interface [polypeptide binding]; other site 693982018797 putative active site [active] 693982018798 putative MgATP binding site [chemical binding]; other site 693982018799 catalytic site [active] 693982018800 metal binding site [ion binding]; metal-binding site 693982018801 putative carbohydrate binding site [chemical binding]; other site 693982018802 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693982018803 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 693982018804 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 693982018805 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 693982018806 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 693982018807 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982018808 Walker A/P-loop; other site 693982018809 ATP binding site [chemical binding]; other site 693982018810 Q-loop/lid; other site 693982018811 ABC transporter signature motif; other site 693982018812 Walker B; other site 693982018813 D-loop; other site 693982018814 H-loop/switch region; other site 693982018815 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982018816 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982018817 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982018818 TM-ABC transporter signature motif; other site 693982018819 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982018820 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982018821 TM-ABC transporter signature motif; other site 693982018822 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 693982018823 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693982018824 Uncharacterized conserved protein [Function unknown]; Region: COG3347 693982018825 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 693982018826 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 693982018827 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 693982018828 dimer interface [polypeptide binding]; other site 693982018829 substrate binding site [chemical binding]; other site 693982018830 metal binding site [ion binding]; metal-binding site 693982018831 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 693982018832 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 693982018833 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 693982018834 Acid Phosphatase; Region: Acid_PPase; cl17256 693982018835 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 693982018836 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 693982018837 Ca2+ binding site [ion binding]; other site 693982018838 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 693982018839 Ca2+ binding site [ion binding]; other site 693982018840 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 693982018841 Ca2+ binding site [ion binding]; other site 693982018842 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 693982018843 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 693982018844 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693982018845 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982018846 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 693982018847 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693982018848 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693982018849 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693982018850 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982018851 Transposase; Region: HTH_Tnp_1; pfam01527 693982018852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693982018853 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 693982018854 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 693982018855 hypothetical protein; Provisional; Region: PRK11281 693982018856 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 693982018857 trimer interface [polypeptide binding]; other site 693982018858 active site 693982018859 substrate binding site [chemical binding]; other site 693982018860 CoA binding site [chemical binding]; other site 693982018861 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693982018862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982018863 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 693982018864 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 693982018865 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 693982018866 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 693982018867 Walker A/P-loop; other site 693982018868 ATP binding site [chemical binding]; other site 693982018869 Q-loop/lid; other site 693982018870 ABC transporter signature motif; other site 693982018871 Walker B; other site 693982018872 D-loop; other site 693982018873 H-loop/switch region; other site 693982018874 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 693982018875 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 693982018876 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693982018877 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693982018878 active site 693982018879 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 693982018880 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 693982018881 ABC-2 type transporter; Region: ABC2_membrane; cl17235 693982018882 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 693982018883 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 693982018884 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982018885 Ketopantoate hydroxymethyltransferase [Coenzyme metabolism]; Region: PanB; COG0413 693982018886 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 693982018887 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693982018888 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 693982018889 [2Fe-2S] cluster binding site [ion binding]; other site 693982018890 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 693982018891 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 693982018892 putative di-iron ligands [ion binding]; other site 693982018893 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982018894 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982018895 DNA binding site [nucleotide binding] 693982018896 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 693982018897 putative ligand binding site [chemical binding]; other site 693982018898 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 693982018899 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 693982018900 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693982018901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 693982018902 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982018903 Homeodomain-like domain; Region: HTH_32; pfam13565 693982018904 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693982018905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693982018906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693982018907 Transposase; Region: HTH_Tnp_1; pfam01527 693982018908 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982018909 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693982018910 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693982018911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982018912 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 693982018913 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693982018914 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693982018915 Hint domain; Region: Hint_2; pfam13403 693982018916 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982018917 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982018918 DNA binding residues [nucleotide binding] 693982018919 dimerization interface [polypeptide binding]; other site 693982018920 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982018921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982018922 active site 693982018923 phosphorylation site [posttranslational modification] 693982018924 intermolecular recognition site; other site 693982018925 dimerization interface [polypeptide binding]; other site 693982018926 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982018927 DNA binding residues [nucleotide binding] 693982018928 dimerization interface [polypeptide binding]; other site 693982018929 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693982018930 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693982018931 DNA binding residues [nucleotide binding] 693982018932 dimerization interface [polypeptide binding]; other site 693982018933 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 693982018934 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 693982018935 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 693982018936 substrate binding site; other site 693982018937 tetramer interface; other site 693982018938 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 693982018939 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 693982018940 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 693982018941 NAD binding site [chemical binding]; other site 693982018942 substrate binding site [chemical binding]; other site 693982018943 homodimer interface [polypeptide binding]; other site 693982018944 active site 693982018945 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 693982018946 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 693982018947 NADP binding site [chemical binding]; other site 693982018948 active site 693982018949 putative substrate binding site [chemical binding]; other site 693982018950 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 693982018951 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 693982018952 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 693982018953 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693982018954 inhibitor-cofactor binding pocket; inhibition site 693982018955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982018956 catalytic residue [active] 693982018957 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693982018958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982018959 NAD(P) binding site [chemical binding]; other site 693982018960 active site 693982018961 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 693982018962 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 693982018963 putative CoA binding site [chemical binding]; other site 693982018964 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 693982018965 putative trimer interface [polypeptide binding]; other site 693982018966 putative CoA binding site [chemical binding]; other site 693982018967 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 693982018968 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693982018969 inhibitor-cofactor binding pocket; inhibition site 693982018970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982018971 catalytic residue [active] 693982018972 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693982018973 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693982018974 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693982018975 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 693982018976 putative trimer interface [polypeptide binding]; other site 693982018977 putative active site [active] 693982018978 putative substrate binding site [chemical binding]; other site 693982018979 putative CoA binding site [chemical binding]; other site 693982018980 Bacterial Ig-like domain; Region: Big_5; pfam13205 693982018981 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 693982018982 Bacterial sugar transferase; Region: Bac_transf; pfam02397 693982018983 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 693982018984 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 693982018985 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 693982018986 Right handed beta helix region; Region: Beta_helix; pfam13229 693982018987 Right handed beta helix region; Region: Beta_helix; pfam13229 693982018988 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 693982018989 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 693982018990 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 693982018991 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693982018992 UDP-galactopyranose mutase; Region: GLF; pfam03275 693982018993 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 693982018994 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 693982018995 Probable Catalytic site; other site 693982018996 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 693982018997 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 693982018998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982018999 S-adenosylmethionine binding site [chemical binding]; other site 693982019000 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 693982019001 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 693982019002 putative active site [active] 693982019003 putative metal binding site [ion binding]; other site 693982019004 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 693982019005 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693982019006 active site 693982019007 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693982019008 active site 693982019009 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693982019010 Phosphopantetheine attachment site; Region: PP-binding; cl09936 693982019011 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 693982019012 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 693982019013 dimer interface [polypeptide binding]; other site 693982019014 active site 693982019015 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693982019016 catalytic residues [active] 693982019017 substrate binding site [chemical binding]; other site 693982019018 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 693982019019 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693982019020 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 693982019021 acyl-activating enzyme (AAE) consensus motif; other site 693982019022 putative AMP binding site [chemical binding]; other site 693982019023 putative active site [active] 693982019024 putative CoA binding site [chemical binding]; other site 693982019025 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 693982019026 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693982019027 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 693982019028 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693982019029 active site 693982019030 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 693982019031 Cadherin repeat-like domain; Region: CA_like; cl15786 693982019032 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 693982019033 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693982019034 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 693982019035 Walker A/P-loop; other site 693982019036 ATP binding site [chemical binding]; other site 693982019037 Q-loop/lid; other site 693982019038 ABC transporter signature motif; other site 693982019039 Walker B; other site 693982019040 D-loop; other site 693982019041 H-loop/switch region; other site 693982019042 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 693982019043 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693982019044 HlyD family secretion protein; Region: HlyD_3; pfam13437 693982019045 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 693982019046 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693982019047 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693982019048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693982019049 Walker A/P-loop; other site 693982019050 ATP binding site [chemical binding]; other site 693982019051 Q-loop/lid; other site 693982019052 ABC transporter signature motif; other site 693982019053 Walker B; other site 693982019054 D-loop; other site 693982019055 H-loop/switch region; other site 693982019056 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 693982019057 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 693982019058 KpsF/GutQ family protein; Region: kpsF; TIGR00393 693982019059 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 693982019060 putative active site [active] 693982019061 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 693982019062 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 693982019063 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 693982019064 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693982019065 active site 693982019066 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693982019067 Glycosyltransferase family 92; Region: Glyco_transf_92; pfam01697 693982019068 active site 693982019069 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 693982019070 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 693982019071 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693982019072 metal-binding site [ion binding] 693982019073 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 693982019074 dimer interface [polypeptide binding]; other site 693982019075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 693982019076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4333 693982019077 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 693982019078 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693982019079 Protein of unknown function (DUF982); Region: DUF982; pfam06169 693982019080 Protein of unknown function (DUF982); Region: DUF982; pfam06169 693982019081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 693982019082 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982019083 Homeodomain-like domain; Region: HTH_32; pfam13565 693982019084 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693982019085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693982019086 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 693982019087 Protein of unknown function (DUF982); Region: DUF982; pfam06169 693982019088 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693982019089 cyclase homology domain; Region: CHD; cd07302 693982019090 nucleotidyl binding site; other site 693982019091 metal binding site [ion binding]; metal-binding site 693982019092 dimer interface [polypeptide binding]; other site 693982019093 Predicted integral membrane protein [Function unknown]; Region: COG5616 693982019094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982019095 TPR motif; other site 693982019096 TPR repeat; Region: TPR_11; pfam13414 693982019097 binding surface 693982019098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982019099 binding surface 693982019100 TPR motif; other site 693982019101 Ribosomal_L32_L32e: L32 is a protein from the large subunit that contains a surface-exposed globular domain and a finger-like projection that extends into the RNA core to stabilize the tertiary structure. L32 does not appear to play a role in forming the...; Region: Ribosomal_L32_L32e; cl00748 693982019102 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693982019103 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982019104 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982019105 DNA binding site [nucleotide binding] 693982019106 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982019107 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693982019108 ligand binding site [chemical binding]; other site 693982019109 dimerization interface [polypeptide binding]; other site 693982019110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289 693982019111 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 693982019112 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693982019113 putative ligand binding site [chemical binding]; other site 693982019114 putative NAD binding site [chemical binding]; other site 693982019115 catalytic site [active] 693982019116 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693982019117 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 693982019118 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 693982019119 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693982019120 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 693982019121 RNA polymerase sigma factor; Provisional; Region: PRK12512 693982019122 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693982019123 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982019124 DNA binding residues [nucleotide binding] 693982019125 Predicted integral membrane protein [Function unknown]; Region: COG5572 693982019126 hypothetical protein; Provisional; Region: PRK05409 693982019127 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 693982019128 YCII-related domain; Region: YCII; cl00999 693982019129 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693982019130 PRC-barrel domain; Region: PRC; pfam05239 693982019131 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 693982019132 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693982019133 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982019134 Transposase domain (DUF772); Region: DUF772; pfam05598 693982019135 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982019136 response regulator; Provisional; Region: PRK13435 693982019137 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 693982019138 CheB methylesterase; Region: CheB_methylest; pfam01339 693982019139 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 693982019140 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 693982019141 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 693982019142 PAS domain; Region: PAS_10; pfam13596 693982019143 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982019144 putative active site [active] 693982019145 heme pocket [chemical binding]; other site 693982019146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693982019147 PAS domain; Region: PAS_9; pfam13426 693982019148 putative active site [active] 693982019149 heme pocket [chemical binding]; other site 693982019150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 693982019151 HWE histidine kinase; Region: HWE_HK; pfam07536 693982019152 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 693982019153 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 693982019154 putative active site [active] 693982019155 short chain dehydrogenase; Provisional; Region: PRK07063 693982019156 classical (c) SDRs; Region: SDR_c; cd05233 693982019157 NAD(P) binding site [chemical binding]; other site 693982019158 active site 693982019159 galactonate dehydratase; Provisional; Region: PRK14017 693982019160 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 693982019161 putative active site pocket [active] 693982019162 putative metal binding site [ion binding]; other site 693982019163 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693982019164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982019165 DNA-binding site [nucleotide binding]; DNA binding site 693982019166 FCD domain; Region: FCD; pfam07729 693982019167 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 693982019168 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 693982019169 ligand binding site [chemical binding]; other site 693982019170 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 693982019171 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982019172 Walker A/P-loop; other site 693982019173 ATP binding site [chemical binding]; other site 693982019174 Q-loop/lid; other site 693982019175 ABC transporter signature motif; other site 693982019176 Walker B; other site 693982019177 D-loop; other site 693982019178 H-loop/switch region; other site 693982019179 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982019180 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982019181 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982019182 TM-ABC transporter signature motif; other site 693982019183 Phosphotransferase enzyme family; Region: APH; pfam01636 693982019184 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 693982019185 active site 693982019186 ATP binding site [chemical binding]; other site 693982019187 substrate binding site [chemical binding]; other site 693982019188 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693982019189 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 693982019190 ligand binding site [chemical binding]; other site 693982019191 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693982019192 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693982019193 Walker A/P-loop; other site 693982019194 ATP binding site [chemical binding]; other site 693982019195 Q-loop/lid; other site 693982019196 ABC transporter signature motif; other site 693982019197 Walker B; other site 693982019198 D-loop; other site 693982019199 H-loop/switch region; other site 693982019200 Methyl-coenzyme M reductase (MCR) gamma subunit. MCR catalyzes the terminal step of methane formation in the energy metabolism of all methanogenic archaea, in which methyl-coenzyme M and coenzyme B are converted to methane and the heterodisulfide of...; Region: MCR_gamma; cl00247 693982019201 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693982019202 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693982019203 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693982019204 TM-ABC transporter signature motif; other site 693982019205 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 693982019206 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693982019207 DNA binding residues [nucleotide binding] 693982019208 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 693982019209 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982019210 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982019211 active site 693982019212 catalytic tetrad [active] 693982019213 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 693982019214 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693982019215 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 693982019216 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 693982019217 putative active site; other site 693982019218 catalytic residue [active] 693982019219 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 693982019220 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 693982019221 TPR repeat; Region: TPR_11; pfam13414 693982019222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693982019223 TPR motif; other site 693982019224 binding surface 693982019225 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 693982019226 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982019227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982019228 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 693982019229 putative effector binding pocket; other site 693982019230 putative dimerization interface [polypeptide binding]; other site 693982019231 short chain dehydrogenase; Provisional; Region: PRK12937 693982019232 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 693982019233 NADP binding site [chemical binding]; other site 693982019234 homodimer interface [polypeptide binding]; other site 693982019235 active site 693982019236 substrate binding site [chemical binding]; other site 693982019237 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 693982019238 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 693982019239 NADP binding site [chemical binding]; other site 693982019240 active site 693982019241 steroid binding site; other site 693982019242 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 693982019243 putative active site [active] 693982019244 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 693982019245 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693982019246 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 693982019247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982019248 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 693982019249 putative dimerization interface [polypeptide binding]; other site 693982019250 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 693982019251 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 693982019252 putative active site [active] 693982019253 putative NTP binding site [chemical binding]; other site 693982019254 putative nucleic acid binding site [nucleotide binding]; other site 693982019255 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 693982019256 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 693982019257 dimer interface [polypeptide binding]; other site 693982019258 active site 693982019259 glycine-pyridoxal phosphate binding site [chemical binding]; other site 693982019260 folate binding site [chemical binding]; other site 693982019261 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 693982019262 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 693982019263 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693982019264 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 693982019265 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 693982019266 diaminopimelate decarboxylase; Region: lysA; TIGR01048 693982019267 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 693982019268 active site 693982019269 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693982019270 substrate binding site [chemical binding]; other site 693982019271 catalytic residues [active] 693982019272 dimer interface [polypeptide binding]; other site 693982019273 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 693982019274 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 693982019275 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 693982019276 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 693982019277 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 693982019278 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693982019279 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 693982019280 catalytic residues [active] 693982019281 catalytic nucleophile [active] 693982019282 Recombinase; Region: Recombinase; pfam07508 693982019283 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693982019284 Helix-turn-helix domain; Region: HTH_28; pfam13518 693982019285 Winged helix-turn helix; Region: HTH_29; pfam13551 693982019286 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693982019287 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 693982019288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982019289 Walker A motif; other site 693982019290 ATP binding site [chemical binding]; other site 693982019291 Walker B motif; other site 693982019292 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693982019293 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693982019294 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693982019295 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693982019296 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693982019297 multiple promoter invertase; Provisional; Region: mpi; PRK13413 693982019298 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693982019299 catalytic residues [active] 693982019300 catalytic nucleophile [active] 693982019301 Presynaptic Site I dimer interface [polypeptide binding]; other site 693982019302 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693982019303 Synaptic Flat tetramer interface [polypeptide binding]; other site 693982019304 Synaptic Site I dimer interface [polypeptide binding]; other site 693982019305 DNA binding site [nucleotide binding] 693982019306 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 693982019307 DNA-binding interface [nucleotide binding]; DNA binding site 693982019308 Predicted deacylase [General function prediction only]; Region: COG3608 693982019309 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 693982019310 active site 693982019311 Zn binding site [ion binding]; other site 693982019312 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 693982019313 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693982019314 substrate binding pocket [chemical binding]; other site 693982019315 membrane-bound complex binding site; other site 693982019316 hinge residues; other site 693982019317 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 693982019318 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693982019319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982019320 putative PBP binding loops; other site 693982019321 dimer interface [polypeptide binding]; other site 693982019322 ABC-ATPase subunit interface; other site 693982019323 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 693982019324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982019325 putative PBP binding loops; other site 693982019326 dimer interface [polypeptide binding]; other site 693982019327 ABC-ATPase subunit interface; other site 693982019328 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693982019329 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693982019330 Walker A/P-loop; other site 693982019331 ATP binding site [chemical binding]; other site 693982019332 Q-loop/lid; other site 693982019333 ABC transporter signature motif; other site 693982019334 Walker B; other site 693982019335 D-loop; other site 693982019336 H-loop/switch region; other site 693982019337 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 693982019338 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 693982019339 dimer interface [polypeptide binding]; other site 693982019340 active site 693982019341 glycine-pyridoxal phosphate binding site [chemical binding]; other site 693982019342 folate binding site [chemical binding]; other site 693982019343 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982019344 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 693982019345 Peptidase family C69; Region: Peptidase_C69; cl17793 693982019346 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982019347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982019348 dimer interface [polypeptide binding]; other site 693982019349 conserved gate region; other site 693982019350 putative PBP binding loops; other site 693982019351 ABC-ATPase subunit interface; other site 693982019352 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982019353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982019354 dimer interface [polypeptide binding]; other site 693982019355 conserved gate region; other site 693982019356 putative PBP binding loops; other site 693982019357 ABC-ATPase subunit interface; other site 693982019358 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 693982019359 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982019360 Walker A/P-loop; other site 693982019361 ATP binding site [chemical binding]; other site 693982019362 Q-loop/lid; other site 693982019363 ABC transporter signature motif; other site 693982019364 Walker B; other site 693982019365 D-loop; other site 693982019366 H-loop/switch region; other site 693982019367 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982019368 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982019369 Walker A/P-loop; other site 693982019370 ATP binding site [chemical binding]; other site 693982019371 Q-loop/lid; other site 693982019372 ABC transporter signature motif; other site 693982019373 Walker B; other site 693982019374 D-loop; other site 693982019375 H-loop/switch region; other site 693982019376 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982019377 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 693982019378 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 693982019379 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693982019380 catalytic residue [active] 693982019381 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 693982019382 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693982019383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693982019384 DNA-binding site [nucleotide binding]; DNA binding site 693982019385 FCD domain; Region: FCD; pfam07729 693982019386 Transposase, Mutator family; Region: Transposase_mut; pfam00872 693982019387 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693982019388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982019389 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693982019390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982019391 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 693982019392 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693982019393 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 693982019394 active site 693982019395 Zn binding site [ion binding]; other site 693982019396 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 693982019397 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 693982019398 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693982019399 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 693982019400 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693982019401 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 693982019402 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693982019403 carboxyltransferase (CT) interaction site; other site 693982019404 biotinylation site [posttranslational modification]; other site 693982019405 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 693982019406 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 693982019407 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 693982019408 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 693982019409 putative active site [active] 693982019410 Predicted deacylase [General function prediction only]; Region: COG3608 693982019411 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 693982019412 active site 693982019413 Zn binding site [ion binding]; other site 693982019414 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693982019415 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 693982019416 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693982019417 Transposase; Region: HTH_Tnp_1; pfam01527 693982019418 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 693982019419 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 693982019420 Int/Topo IB signature motif; other site 693982019421 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 693982019422 Putative transposase; Region: Y2_Tnp; pfam04986 693982019423 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 693982019424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693982019425 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 693982019426 homotrimer interaction site [polypeptide binding]; other site 693982019427 putative active site [active] 693982019428 Peptidase C26; Region: Peptidase_C26; pfam07722 693982019429 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 693982019430 catalytic triad [active] 693982019431 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 693982019432 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 693982019433 metal binding site [ion binding]; metal-binding site 693982019434 dimer interface [polypeptide binding]; other site 693982019435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982019436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982019437 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982019438 dimerization interface [polypeptide binding]; other site 693982019439 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 693982019440 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693982019441 Walker A/P-loop; other site 693982019442 ATP binding site [chemical binding]; other site 693982019443 Q-loop/lid; other site 693982019444 ABC transporter signature motif; other site 693982019445 Walker B; other site 693982019446 D-loop; other site 693982019447 H-loop/switch region; other site 693982019448 Transposase domain (DUF772); Region: DUF772; pfam05598 693982019449 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693982019450 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 693982019451 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693982019452 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693982019453 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982019454 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693982019455 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693982019456 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693982019457 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982019458 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693982019459 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693982019460 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693982019461 Transposase; Region: HTH_Tnp_1; pfam01527 693982019462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982019463 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693982019464 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 693982019465 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693982019466 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693982019467 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693982019468 glutamine synthetase; Provisional; Region: glnA; PRK09469 693982019469 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 693982019470 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693982019471 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 693982019472 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 693982019473 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 693982019474 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 693982019475 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 693982019476 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 693982019477 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 693982019478 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693982019479 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982019480 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693982019481 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693982019482 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982019483 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693982019484 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693982019485 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 693982019486 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693982019487 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 693982019488 nucleotide binding site [chemical binding]; other site 693982019489 substrate binding site [chemical binding]; other site 693982019490 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 693982019491 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 693982019492 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 693982019493 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 693982019494 active site 693982019495 dimer interface [polypeptide binding]; other site 693982019496 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 693982019497 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 693982019498 active site 693982019499 FMN binding site [chemical binding]; other site 693982019500 substrate binding site [chemical binding]; other site 693982019501 3Fe-4S cluster binding site [ion binding]; other site 693982019502 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 693982019503 domain interface; other site 693982019504 glutamine synthetase; Provisional; Region: glnA; PRK09469 693982019505 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 693982019506 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693982019507 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 693982019508 Staphylococcal nuclease homologues; Region: SNc; smart00318 693982019509 Catalytic site; other site 693982019510 Protein of unknown function (DUF736); Region: DUF736; pfam05284 693982019511 transposase; Validated; Region: PRK08181 693982019512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982019513 Walker A motif; other site 693982019514 ATP binding site [chemical binding]; other site 693982019515 Walker B motif; other site 693982019516 Integrase core domain; Region: rve; pfam00665 693982019517 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 693982019518 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 693982019519 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 693982019520 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693982019521 catalytic residue [active] 693982019522 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693982019523 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982019524 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693982019525 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693982019526 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693982019527 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982019528 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693982019529 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693982019530 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 693982019531 Amidase; Region: Amidase; cl11426 693982019532 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 693982019533 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982019534 Walker A/P-loop; other site 693982019535 ATP binding site [chemical binding]; other site 693982019536 Q-loop/lid; other site 693982019537 ABC transporter signature motif; other site 693982019538 Walker B; other site 693982019539 D-loop; other site 693982019540 H-loop/switch region; other site 693982019541 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982019542 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 693982019543 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982019544 Walker A/P-loop; other site 693982019545 ATP binding site [chemical binding]; other site 693982019546 Q-loop/lid; other site 693982019547 ABC transporter signature motif; other site 693982019548 Walker B; other site 693982019549 D-loop; other site 693982019550 H-loop/switch region; other site 693982019551 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982019552 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982019553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982019554 putative PBP binding loops; other site 693982019555 dimer interface [polypeptide binding]; other site 693982019556 ABC-ATPase subunit interface; other site 693982019557 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982019558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982019559 ABC-ATPase subunit interface; other site 693982019560 putative PBP binding loops; other site 693982019561 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982019562 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 693982019563 Transposase domain (DUF772); Region: DUF772; pfam05598 693982019564 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693982019565 Transposase domain (DUF772); Region: DUF772; pfam05598 693982019566 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693982019567 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 693982019568 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 693982019569 [2Fe-2S] cluster binding site [ion binding]; other site 693982019570 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 693982019571 putative alpha subunit interface [polypeptide binding]; other site 693982019572 putative active site [active] 693982019573 putative substrate binding site [chemical binding]; other site 693982019574 Fe binding site [ion binding]; other site 693982019575 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 693982019576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982019577 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693982019578 dimerization interface [polypeptide binding]; other site 693982019579 Predicted transcriptional regulator [Transcription]; Region: COG4957 693982019580 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 693982019581 oligomerisation interface [polypeptide binding]; other site 693982019582 mobile loop; other site 693982019583 roof hairpin; other site 693982019584 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693982019585 DNA-binding site [nucleotide binding]; DNA binding site 693982019586 RNA-binding motif; other site 693982019587 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 693982019588 Uncharacterized conserved protein [Function unknown]; Region: COG5556 693982019589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693982019590 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693982019591 Coenzyme A binding pocket [chemical binding]; other site 693982019592 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693982019593 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982019594 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982019595 active site 693982019596 catalytic tetrad [active] 693982019597 transposase; Validated; Region: PRK08181 693982019598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693982019599 Walker A motif; other site 693982019600 ATP binding site [chemical binding]; other site 693982019601 Walker B motif; other site 693982019602 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693982019603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982019604 short chain dehydrogenase; Provisional; Region: PRK06500 693982019605 classical (c) SDRs; Region: SDR_c; cd05233 693982019606 NAD(P) binding site [chemical binding]; other site 693982019607 active site 693982019608 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 693982019609 Predicted transcriptional regulator [Transcription]; Region: COG2944 693982019610 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693982019611 non-specific DNA binding site [nucleotide binding]; other site 693982019612 salt bridge; other site 693982019613 sequence-specific DNA binding site [nucleotide binding]; other site 693982019614 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693982019615 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 693982019616 DNA-binding interface [nucleotide binding]; DNA binding site 693982019617 Homeodomain-like domain; Region: HTH_32; pfam13565 693982019618 Integrase core domain; Region: rve; pfam00665 693982019619 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693982019620 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693982019621 DNA binding site [nucleotide binding] 693982019622 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 693982019623 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693982019624 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693982019625 Walker A motif; other site 693982019626 Walker A motif; other site 693982019627 ATP binding site [chemical binding]; other site 693982019628 Walker B motif; other site 693982019629 KaiC; Region: KaiC; pfam06745 693982019630 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 693982019631 Walker A motif; other site 693982019632 ATP binding site [chemical binding]; other site 693982019633 Walker B motif; other site 693982019634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 693982019635 HWE histidine kinase; Region: HWE_HK; pfam07536 693982019636 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693982019637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693982019638 active site 693982019639 phosphorylation site [posttranslational modification] 693982019640 intermolecular recognition site; other site 693982019641 dimerization interface [polypeptide binding]; other site 693982019642 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 693982019643 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 693982019644 Walker A/P-loop; other site 693982019645 ATP binding site [chemical binding]; other site 693982019646 Q-loop/lid; other site 693982019647 ABC transporter signature motif; other site 693982019648 Walker B; other site 693982019649 D-loop; other site 693982019650 H-loop/switch region; other site 693982019651 TOBE-like domain; Region: TOBE_3; pfam12857 693982019652 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 693982019653 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693982019654 CTP synthase (UTP-ammonia lyase) [Nucleotide transport and metabolism]; Region: PyrG; COG0504 693982019655 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 693982019656 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 693982019657 Flavin binding site [chemical binding]; other site 693982019658 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693982019659 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 693982019660 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693982019661 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693982019662 active site 693982019663 catalytic tetrad [active] 693982019664 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 693982019665 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982019666 Walker A/P-loop; other site 693982019667 ATP binding site [chemical binding]; other site 693982019668 Q-loop/lid; other site 693982019669 ABC transporter signature motif; other site 693982019670 Walker B; other site 693982019671 D-loop; other site 693982019672 H-loop/switch region; other site 693982019673 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 693982019674 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 693982019675 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693982019676 Walker A/P-loop; other site 693982019677 ATP binding site [chemical binding]; other site 693982019678 Q-loop/lid; other site 693982019679 ABC transporter signature motif; other site 693982019680 Walker B; other site 693982019681 D-loop; other site 693982019682 H-loop/switch region; other site 693982019683 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693982019684 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693982019685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982019686 dimer interface [polypeptide binding]; other site 693982019687 conserved gate region; other site 693982019688 putative PBP binding loops; other site 693982019689 ABC-ATPase subunit interface; other site 693982019690 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693982019691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693982019692 dimer interface [polypeptide binding]; other site 693982019693 conserved gate region; other site 693982019694 putative PBP binding loops; other site 693982019695 ABC-ATPase subunit interface; other site 693982019696 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 693982019697 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693982019698 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 693982019699 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 693982019700 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 693982019701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693982019702 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 693982019703 NAD(P) binding site [chemical binding]; other site 693982019704 active site 693982019705 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 693982019706 hypothetical protein; Provisional; Region: PRK07236 693982019707 Putative NADH-flavin reductase [General function prediction only]; Region: COG2910 693982019708 NADH(P)-binding; Region: NAD_binding_10; pfam13460 693982019709 NAD(P) binding site [chemical binding]; other site 693982019710 active site 693982019711 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 693982019712 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 693982019713 active site 693982019714 non-prolyl cis peptide bond; other site 693982019715 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 693982019716 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 693982019717 Moco binding site; other site 693982019718 metal coordination site [ion binding]; other site 693982019719 dimerization interface [polypeptide binding]; other site 693982019720 Fic family protein [Function unknown]; Region: COG3177 693982019721 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 693982019722 Fic/DOC family; Region: Fic; pfam02661 693982019723 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 693982019724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693982019725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693982019726 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693982019727 putative effector binding pocket; other site 693982019728 dimerization interface [polypeptide binding]; other site 693982019729 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 693982019730 NmrA-like family; Region: NmrA; pfam05368 693982019731 NADP binding site [chemical binding]; other site 693982019732 active site 693982019733 regulatory binding site [polypeptide binding]; other site 693982019734 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 693982019735 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982019736 Transposase domain (DUF772); Region: DUF772; pfam05598 693982019737 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 693982019738 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 693982019739 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 693982019740 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 693982019741 LytTr DNA-binding domain; Region: LytTR; smart00850 693982019742 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 693982019743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693982019744 S-adenosylmethionine binding site [chemical binding]; other site 693982019745 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693982019746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982019747 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693982019748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693982019749 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 693982019750 Domain of unknown function (DUF4206); Region: DUF4206; pfam13901 693982019751 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 693982019752 TRAP binding interface [polypeptide binding]; other site 693982019753 Zn binding site [ion binding]; other site 693982019754 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142 693982019755 ParB-like nuclease domain; Region: ParBc; cl02129 693982019756 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 693982019757 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 693982019758 dimer interface [polypeptide binding]; other site 693982019759 active site 693982019760 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693982019761 catalytic residues [active] 693982019762 substrate binding site [chemical binding]; other site 693982019763 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 693982019764 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 693982019765 dimer interface [polypeptide binding]; other site 693982019766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693982019767 catalytic residue [active] 693982019768 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693982019769 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 693982019770 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 693982019771 IucA / IucC family; Region: IucA_IucC; pfam04183 693982019772 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 693982019773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693982019774 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693982019775 putative substrate translocation pore; other site 693982019776 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 693982019777 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 693982019778 putative ligand binding residues [chemical binding]; other site 693982019779 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693982019780 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693982019781 N-terminal plug; other site 693982019782 ligand-binding site [chemical binding]; other site 693982019783 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693982019784 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693982019785 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693982019786 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693982019787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693982019788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693982019789 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 693982019790 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 693982019791 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 693982019792 Domain of unknown function (DUF4209); Region: DUF4209; pfam13910 693982019793 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 693982019794 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 693982019795 putative active site [active] 693982019796 homotetrameric interface [polypeptide binding]; other site 693982019797 metal binding site [ion binding]; metal-binding site 693982019798 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 693982019799 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693982019800 active site 693982019801 DNA binding site [nucleotide binding] 693982019802 Int/Topo IB signature motif; other site 693982019803 replication initiation protein RepC; Provisional; Region: PRK13824 693982019804 Replication protein C N-terminal domain; Region: RP-C; pfam03428 693982019805 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 693982019806 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 693982019807 ParB-like nuclease domain; Region: ParBc; pfam02195 693982019808 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 693982019809 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693982019810 P-loop; other site 693982019811 Magnesium ion binding site [ion binding]; other site 693982019812 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693982019813 Magnesium ion binding site [ion binding]; other site