-- dump date 20140620_070552 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698936000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 698936000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 698936000003 Bacterial dnaA protein; Region: Bac_DnaA; pfam00308 698936000004 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698936000005 DnaA box-binding interface [nucleotide binding]; other site 698936000006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 698936000007 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 698936000008 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698936000009 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698936000010 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 698936000011 putative hydrophobic ligand binding site [chemical binding]; other site 698936000012 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 698936000013 SnoaL-like domain; Region: SnoaL_3; pfam13474 698936000014 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 698936000015 putative dimer interface [polypeptide binding]; other site 698936000016 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936000017 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 698936000018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698936000019 FeS/SAM binding site; other site 698936000020 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698936000021 active site 698936000022 dimerization interface [polypeptide binding]; other site 698936000023 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698936000024 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936000025 active site 698936000026 ribonuclease PH; Reviewed; Region: rph; PRK00173 698936000027 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698936000028 hexamer interface [polypeptide binding]; other site 698936000029 active site 698936000030 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698936000031 heat shock protein GrpE; Provisional; Region: PRK14141 698936000032 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698936000033 dimer interface [polypeptide binding]; other site 698936000034 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698936000035 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698936000036 active site 698936000037 phosphorylation site [posttranslational modification] 698936000038 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698936000039 30S subunit binding site; other site 698936000040 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 698936000041 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 698936000042 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 698936000043 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 698936000044 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 698936000045 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 698936000046 Walker A/P-loop; other site 698936000047 ATP binding site [chemical binding]; other site 698936000048 Q-loop/lid; other site 698936000049 ABC transporter signature motif; other site 698936000050 Walker B; other site 698936000051 D-loop; other site 698936000052 H-loop/switch region; other site 698936000053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 698936000054 OstA-like protein; Region: OstA; pfam03968 698936000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 698936000056 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 698936000057 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 698936000058 tandem repeat interface [polypeptide binding]; other site 698936000059 oligomer interface [polypeptide binding]; other site 698936000060 active site residues [active] 698936000061 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 698936000062 IHF dimer interface [polypeptide binding]; other site 698936000063 IHF - DNA interface [nucleotide binding]; other site 698936000064 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 698936000065 putative hydrophobic ligand binding site [chemical binding]; other site 698936000066 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 698936000067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936000068 S-adenosylmethionine binding site [chemical binding]; other site 698936000069 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698936000070 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698936000071 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698936000072 lipoprotein signal peptidase; Provisional; Region: PRK14795 698936000073 PAS domain; Region: PAS_9; pfam13426 698936000074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936000075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936000076 dimer interface [polypeptide binding]; other site 698936000077 phosphorylation site [posttranslational modification] 698936000078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936000079 ATP binding site [chemical binding]; other site 698936000080 Mg2+ binding site [ion binding]; other site 698936000081 G-X-G motif; other site 698936000082 Response regulator receiver domain; Region: Response_reg; pfam00072 698936000083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936000084 active site 698936000085 phosphorylation site [posttranslational modification] 698936000086 intermolecular recognition site; other site 698936000087 dimerization interface [polypeptide binding]; other site 698936000088 Putative hemolysin [General function prediction only]; Region: COG3176 698936000089 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 698936000090 Malic enzyme, N-terminal domain; Region: malic; pfam00390 698936000091 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 698936000092 putative NAD(P) binding site [chemical binding]; other site 698936000093 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 698936000094 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 698936000095 MutS domain I; Region: MutS_I; pfam01624 698936000096 MutS domain II; Region: MutS_II; pfam05188 698936000097 MutS domain III; Region: MutS_III; pfam05192 698936000098 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 698936000099 Walker A/P-loop; other site 698936000100 ATP binding site [chemical binding]; other site 698936000101 Q-loop/lid; other site 698936000102 ABC transporter signature motif; other site 698936000103 Walker B; other site 698936000104 D-loop; other site 698936000105 H-loop/switch region; other site 698936000106 PII uridylyl-transferase; Provisional; Region: PRK05092 698936000107 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698936000108 metal binding triad; other site 698936000109 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698936000110 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698936000111 Zn2+ binding site [ion binding]; other site 698936000112 Mg2+ binding site [ion binding]; other site 698936000113 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698936000114 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 698936000115 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 698936000116 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 698936000117 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936000118 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 698936000119 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698936000120 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698936000121 active site 698936000122 HIGH motif; other site 698936000123 dimer interface [polypeptide binding]; other site 698936000124 KMSKS motif; other site 698936000125 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698936000126 Ligand Binding Site [chemical binding]; other site 698936000127 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 698936000128 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 698936000129 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 698936000130 Glycoprotease family; Region: Peptidase_M22; pfam00814 698936000131 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698936000132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936000133 Coenzyme A binding pocket [chemical binding]; other site 698936000134 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698936000135 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698936000136 putative acyl-acceptor binding pocket; other site 698936000137 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 698936000138 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698936000139 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698936000140 FeS/SAM binding site; other site 698936000141 TRAM domain; Region: TRAM; pfam01938 698936000142 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698936000143 PhoH-like protein; Region: PhoH; pfam02562 698936000144 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 698936000145 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698936000146 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698936000147 Transporter associated domain; Region: CorC_HlyC; smart01091 698936000148 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 698936000149 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 698936000150 putative active site [active] 698936000151 catalytic triad [active] 698936000152 putative dimer interface [polypeptide binding]; other site 698936000153 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698936000154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936000155 non-specific DNA binding site [nucleotide binding]; other site 698936000156 salt bridge; other site 698936000157 sequence-specific DNA binding site [nucleotide binding]; other site 698936000158 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698936000159 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698936000160 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698936000161 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698936000162 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 698936000163 Uncharacterized small protein [Function unknown]; Region: COG5568 698936000164 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 698936000165 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 698936000166 putative dimer interface [polypeptide binding]; other site 698936000167 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698936000168 active site 698936000169 tetramer interface [polypeptide binding]; other site 698936000170 Cache domain; Region: Cache_1; pfam02743 698936000171 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 698936000172 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 698936000173 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698936000174 dimer interface [polypeptide binding]; other site 698936000175 putative CheW interface [polypeptide binding]; other site 698936000176 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698936000177 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698936000178 substrate binding site [chemical binding]; other site 698936000179 dimer interface [polypeptide binding]; other site 698936000180 ATP binding site [chemical binding]; other site 698936000181 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 698936000182 RmuC family; Region: RmuC; pfam02646 698936000183 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698936000184 active site 698936000185 catalytic residues [active] 698936000186 metal binding site [ion binding]; metal-binding site 698936000187 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698936000188 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698936000189 putative active site [active] 698936000190 substrate binding site [chemical binding]; other site 698936000191 putative cosubstrate binding site; other site 698936000192 catalytic site [active] 698936000193 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698936000194 substrate binding site [chemical binding]; other site 698936000195 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698936000196 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698936000197 dimerization interface 3.5A [polypeptide binding]; other site 698936000198 active site 698936000199 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 698936000200 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 698936000201 metal binding site [ion binding]; metal-binding site 698936000202 dimer interface [polypeptide binding]; other site 698936000203 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 698936000204 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698936000205 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936000206 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936000207 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698936000208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936000209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936000210 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 698936000211 putative effector binding pocket; other site 698936000212 putative dimerization interface [polypeptide binding]; other site 698936000213 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698936000214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698936000215 ATP binding site [chemical binding]; other site 698936000216 putative Mg++ binding site [ion binding]; other site 698936000217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698936000218 nucleotide binding region [chemical binding]; other site 698936000219 ATP-binding site [chemical binding]; other site 698936000220 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 698936000221 RNA binding site [nucleotide binding]; other site 698936000222 Predicted membrane protein [Function unknown]; Region: COG3152 698936000223 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 698936000224 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 698936000225 trimer interface [polypeptide binding]; other site 698936000226 active site 698936000227 substrate binding site [chemical binding]; other site 698936000228 CoA binding site [chemical binding]; other site 698936000229 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698936000230 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 698936000231 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 698936000232 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 698936000233 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 698936000234 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698936000235 DNA binding site [nucleotide binding] 698936000236 active site 698936000237 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 698936000238 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 698936000239 tetramer interface [polypeptide binding]; other site 698936000240 active site 698936000241 Mg2+/Mn2+ binding site [ion binding]; other site 698936000242 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 698936000243 homohexameric interface [polypeptide binding]; other site 698936000244 feedback inhibition sensing region; other site 698936000245 carbamate kinase; Reviewed; Region: PRK12686 698936000246 nucleotide binding site [chemical binding]; other site 698936000247 N-acetyl-L-glutamate binding site [chemical binding]; other site 698936000248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 698936000249 Anti-sigma-K factor rskA; Region: RskA; pfam10099 698936000250 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 698936000251 SelR domain; Region: SelR; pfam01641 698936000252 Predicted membrane protein [Function unknown]; Region: COG4803 698936000253 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 698936000254 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 698936000255 G1 box; other site 698936000256 GTP/Mg2+ binding site [chemical binding]; other site 698936000257 Switch I region; other site 698936000258 G2 box; other site 698936000259 G3 box; other site 698936000260 Switch II region; other site 698936000261 G4 box; other site 698936000262 G5 box; other site 698936000263 membrane protein insertase; Provisional; Region: PRK01318 698936000264 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 698936000265 ribonuclease P; Reviewed; Region: rnpA; PRK01313 698936000266 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 698936000267 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698936000268 dimerization interface [polypeptide binding]; other site 698936000269 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698936000270 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698936000271 dimer interface [polypeptide binding]; other site 698936000272 putative CheW interface [polypeptide binding]; other site 698936000273 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698936000274 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698936000275 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 698936000276 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698936000277 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936000278 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698936000279 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936000280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936000281 ATP binding site [chemical binding]; other site 698936000282 Mg2+ binding site [ion binding]; other site 698936000283 G-X-G motif; other site 698936000284 tetracycline repressor protein TetR; Provisional; Region: PRK13756 698936000285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936000286 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 698936000287 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698936000288 homotrimer interaction site [polypeptide binding]; other site 698936000289 putative active site [active] 698936000290 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 698936000291 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698936000292 phosphate binding site [ion binding]; other site 698936000293 Domain of unknown function DUF11; Region: DUF11; cl17728 698936000294 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 698936000295 Domain of unknown function DUF11; Region: DUF11; cl17728 698936000296 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 698936000297 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698936000298 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 698936000299 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 698936000300 putative deacylase active site [active] 698936000301 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 698936000302 Uncharacterized conserved protein [Function unknown]; Region: COG5579 698936000303 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936000304 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936000305 active site 698936000306 catalytic tetrad [active] 698936000307 Uncharacterized conserved protein [Function unknown]; Region: COG1739 698936000308 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698936000309 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698936000310 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 698936000311 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 698936000312 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 698936000313 Glutamate binding site [chemical binding]; other site 698936000314 NAD binding site [chemical binding]; other site 698936000315 catalytic residues [active] 698936000316 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698936000317 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 698936000318 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 698936000319 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698936000320 active site 698936000321 metal binding site [ion binding]; metal-binding site 698936000322 hexamer interface [polypeptide binding]; other site 698936000323 FecR protein; Region: FecR; pfam04773 698936000324 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698936000325 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698936000326 ligand binding site [chemical binding]; other site 698936000327 flexible hinge region; other site 698936000328 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 698936000329 putative switch regulator; other site 698936000330 non-specific DNA interactions [nucleotide binding]; other site 698936000331 DNA binding site [nucleotide binding] 698936000332 sequence specific DNA binding site [nucleotide binding]; other site 698936000333 putative cAMP binding site [chemical binding]; other site 698936000334 Predicted membrane protein [Function unknown]; Region: COG2259 698936000335 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 698936000336 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698936000337 non-specific DNA interactions [nucleotide binding]; other site 698936000338 DNA binding site [nucleotide binding] 698936000339 sequence specific DNA binding site [nucleotide binding]; other site 698936000340 putative cAMP binding site [chemical binding]; other site 698936000341 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698936000342 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698936000343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936000344 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 698936000345 ligand binding site [chemical binding]; other site 698936000346 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936000347 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936000348 TM-ABC transporter signature motif; other site 698936000349 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698936000350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936000351 Walker A/P-loop; other site 698936000352 ATP binding site [chemical binding]; other site 698936000353 Q-loop/lid; other site 698936000354 ABC transporter signature motif; other site 698936000355 Walker B; other site 698936000356 D-loop; other site 698936000357 H-loop/switch region; other site 698936000358 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 698936000359 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 698936000360 active site 698936000361 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 698936000362 active site 698936000363 substrate binding pocket [chemical binding]; other site 698936000364 dimer interface [polypeptide binding]; other site 698936000365 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698936000366 active site 698936000367 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698936000368 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 698936000369 putative substrate binding site [chemical binding]; other site 698936000370 putative ATP binding site [chemical binding]; other site 698936000371 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 698936000372 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698936000373 active site 698936000374 dimer interface [polypeptide binding]; other site 698936000375 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698936000376 dimer interface [polypeptide binding]; other site 698936000377 active site 698936000378 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 698936000379 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 698936000380 acyl-activating enzyme (AAE) consensus motif; other site 698936000381 putative AMP binding site [chemical binding]; other site 698936000382 putative active site [active] 698936000383 putative CoA binding site [chemical binding]; other site 698936000384 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698936000385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936000386 putative substrate translocation pore; other site 698936000387 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698936000388 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698936000389 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698936000390 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698936000391 putative acyl-acceptor binding pocket; other site 698936000392 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 698936000393 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698936000394 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 698936000395 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 698936000396 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 698936000397 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698936000398 FMN binding site [chemical binding]; other site 698936000399 substrate binding site [chemical binding]; other site 698936000400 putative catalytic residue [active] 698936000401 Uncharacterized conserved protein [Function unknown]; Region: COG2326 698936000402 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698936000403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936000404 dimer interface [polypeptide binding]; other site 698936000405 phosphorylation site [posttranslational modification] 698936000406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936000407 ATP binding site [chemical binding]; other site 698936000408 Mg2+ binding site [ion binding]; other site 698936000409 G-X-G motif; other site 698936000410 PBP superfamily domain; Region: PBP_like_2; pfam12849 698936000411 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 698936000412 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 698936000413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936000414 dimer interface [polypeptide binding]; other site 698936000415 conserved gate region; other site 698936000416 putative PBP binding loops; other site 698936000417 ABC-ATPase subunit interface; other site 698936000418 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 698936000419 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 698936000420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936000421 dimer interface [polypeptide binding]; other site 698936000422 conserved gate region; other site 698936000423 putative PBP binding loops; other site 698936000424 ABC-ATPase subunit interface; other site 698936000425 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 698936000426 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 698936000427 Walker A/P-loop; other site 698936000428 ATP binding site [chemical binding]; other site 698936000429 Q-loop/lid; other site 698936000430 ABC transporter signature motif; other site 698936000431 Walker B; other site 698936000432 D-loop; other site 698936000433 H-loop/switch region; other site 698936000434 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698936000435 PhoU domain; Region: PhoU; pfam01895 698936000436 PhoU domain; Region: PhoU; pfam01895 698936000437 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 698936000438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936000439 active site 698936000440 phosphorylation site [posttranslational modification] 698936000441 intermolecular recognition site; other site 698936000442 dimerization interface [polypeptide binding]; other site 698936000443 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936000444 DNA binding site [nucleotide binding] 698936000445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 698936000446 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 698936000447 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698936000448 inhibitor-cofactor binding pocket; inhibition site 698936000449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936000450 catalytic residue [active] 698936000451 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698936000452 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698936000453 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698936000454 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 698936000455 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 698936000456 dimerization interface [polypeptide binding]; other site 698936000457 domain crossover interface; other site 698936000458 redox-dependent activation switch; other site 698936000459 Uncharacterized protein affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism]; Region: ApaG; COG2967 698936000460 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698936000461 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 698936000462 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698936000463 homodimer interface [polypeptide binding]; other site 698936000464 substrate-cofactor binding pocket; other site 698936000465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936000466 catalytic residue [active] 698936000467 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 698936000468 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 698936000469 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698936000470 trimer interface [polypeptide binding]; other site 698936000471 active site 698936000472 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 698936000473 trimer interface [polypeptide binding]; other site 698936000474 active site 698936000475 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 698936000476 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 698936000477 tellurite resistance protein terB; Region: terB; cd07176 698936000478 putative metal binding site [ion binding]; other site 698936000479 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 698936000480 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 698936000481 Predicted transcriptional regulator [Transcription]; Region: COG2932 698936000482 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698936000483 Catalytic site [active] 698936000484 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 698936000485 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 698936000486 Predicted transcriptional regulators [Transcription]; Region: COG1733 698936000487 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 698936000488 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 698936000489 putative hydrophobic ligand binding site [chemical binding]; other site 698936000490 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 698936000491 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698936000492 substrate binding site [chemical binding]; other site 698936000493 oxyanion hole (OAH) forming residues; other site 698936000494 trimer interface [polypeptide binding]; other site 698936000495 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 698936000496 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 698936000497 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 698936000498 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 698936000499 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698936000500 dimer interface [polypeptide binding]; other site 698936000501 active site 698936000502 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 698936000503 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 698936000504 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 698936000505 FAD binding site [chemical binding]; other site 698936000506 substrate binding site [chemical binding]; other site 698936000507 catalytic residues [active] 698936000508 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 698936000509 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 698936000510 Sel1 repeat; Region: Sel1; pfam08238 698936000511 Sel1-like repeats; Region: SEL1; smart00671 698936000512 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 698936000513 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698936000514 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698936000515 conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186 698936000516 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936000517 AsnC family; Region: AsnC_trans_reg; pfam01037 698936000518 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698936000519 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 698936000520 putative active site [active] 698936000521 putative metal binding site [ion binding]; other site 698936000522 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 698936000523 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698936000524 ATP binding site [chemical binding]; other site 698936000525 putative Mg++ binding site [ion binding]; other site 698936000526 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698936000527 nucleotide binding region [chemical binding]; other site 698936000528 ATP-binding site [chemical binding]; other site 698936000529 DEAD/H associated; Region: DEAD_assoc; pfam08494 698936000530 Predicted transcriptional regulator [Transcription]; Region: COG1959 698936000531 Transcriptional regulator; Region: Rrf2; pfam02082 698936000532 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698936000533 Uncharacterized conserved protein [Function unknown]; Region: COG2128 698936000534 Uncharacterized conserved protein [Function unknown]; Region: COG1284 698936000535 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 698936000536 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 698936000537 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 698936000538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936000539 S-adenosylmethionine binding site [chemical binding]; other site 698936000540 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 698936000541 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 698936000542 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698936000543 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 698936000544 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 698936000545 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698936000546 quinone interaction residues [chemical binding]; other site 698936000547 active site 698936000548 catalytic residues [active] 698936000549 FMN binding site [chemical binding]; other site 698936000550 substrate binding site [chemical binding]; other site 698936000551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 698936000552 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936000553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936000554 active site 698936000555 phosphorylation site [posttranslational modification] 698936000556 intermolecular recognition site; other site 698936000557 dimerization interface [polypeptide binding]; other site 698936000558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936000559 DNA binding residues [nucleotide binding] 698936000560 dimerization interface [polypeptide binding]; other site 698936000561 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 698936000562 Na binding site [ion binding]; other site 698936000563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936000564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936000565 dimer interface [polypeptide binding]; other site 698936000566 phosphorylation site [posttranslational modification] 698936000567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936000568 ATP binding site [chemical binding]; other site 698936000569 Mg2+ binding site [ion binding]; other site 698936000570 G-X-G motif; other site 698936000571 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698936000572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936000573 active site 698936000574 phosphorylation site [posttranslational modification] 698936000575 intermolecular recognition site; other site 698936000576 dimerization interface [polypeptide binding]; other site 698936000577 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 698936000578 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698936000579 aspartate aminotransferase; Provisional; Region: PRK06108 698936000580 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936000581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936000582 homodimer interface [polypeptide binding]; other site 698936000583 catalytic residue [active] 698936000584 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698936000585 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698936000586 NAD binding site [chemical binding]; other site 698936000587 homodimer interface [polypeptide binding]; other site 698936000588 active site 698936000589 substrate binding site [chemical binding]; other site 698936000590 chorismate mutase related enzymes; Region: CM-like; TIGR01803 698936000591 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 698936000592 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698936000593 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 698936000594 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698936000595 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 698936000596 metal binding site [ion binding]; metal-binding site 698936000597 putative dimer interface [polypeptide binding]; other site 698936000598 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936000599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936000600 dimer interface [polypeptide binding]; other site 698936000601 conserved gate region; other site 698936000602 putative PBP binding loops; other site 698936000603 ABC-ATPase subunit interface; other site 698936000604 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936000605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936000606 dimer interface [polypeptide binding]; other site 698936000607 conserved gate region; other site 698936000608 putative PBP binding loops; other site 698936000609 ABC-ATPase subunit interface; other site 698936000610 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936000611 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698936000612 substrate binding pocket [chemical binding]; other site 698936000613 membrane-bound complex binding site; other site 698936000614 hinge residues; other site 698936000615 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 698936000616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936000617 Walker A/P-loop; other site 698936000618 ATP binding site [chemical binding]; other site 698936000619 Q-loop/lid; other site 698936000620 ABC transporter signature motif; other site 698936000621 Walker B; other site 698936000622 D-loop; other site 698936000623 H-loop/switch region; other site 698936000624 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 698936000625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936000626 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 698936000627 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 698936000628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936000629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936000630 homodimer interface [polypeptide binding]; other site 698936000631 catalytic residue [active] 698936000632 hypothetical protein; Provisional; Region: PRK07524 698936000633 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698936000634 PYR/PP interface [polypeptide binding]; other site 698936000635 dimer interface [polypeptide binding]; other site 698936000636 TPP binding site [chemical binding]; other site 698936000637 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698936000638 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 698936000639 TPP-binding site [chemical binding]; other site 698936000640 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 698936000641 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 698936000642 Protein export membrane protein; Region: SecD_SecF; pfam02355 698936000643 Rrf2 family protein; Region: rrf2_super; TIGR00738 698936000644 Transcriptional regulator; Region: Rrf2; pfam02082 698936000645 KpsF/GutQ family protein; Region: kpsF; TIGR00393 698936000646 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 698936000647 putative active site [active] 698936000648 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 698936000649 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 698936000650 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 698936000651 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 698936000652 Sulfatase; Region: Sulfatase; cl17466 698936000653 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698936000654 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 698936000655 putative NAD(P) binding site [chemical binding]; other site 698936000656 homotetramer interface [polypeptide binding]; other site 698936000657 active site 698936000658 homodimer interface [polypeptide binding]; other site 698936000659 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698936000660 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698936000661 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698936000662 catalytic residue [active] 698936000663 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 698936000664 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698936000665 active site 698936000666 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698936000667 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698936000668 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 698936000669 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 698936000670 Enoylreductase; Region: PKS_ER; smart00829 698936000671 NAD(P) binding site [chemical binding]; other site 698936000672 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 698936000673 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 698936000674 putative NADP binding site [chemical binding]; other site 698936000675 active site 698936000676 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698936000677 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 698936000678 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 698936000679 SLBB domain; Region: SLBB; pfam10531 698936000680 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 698936000681 Isochorismatase family; Region: Isochorismatase; pfam00857 698936000682 catalytic triad [active] 698936000683 metal binding site [ion binding]; metal-binding site 698936000684 conserved cis-peptide bond; other site 698936000685 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 698936000686 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 698936000687 active site 698936000688 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 698936000689 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 698936000690 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698936000691 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 698936000692 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 698936000693 Uncharacterized conserved protein [Function unknown]; Region: COG5569 698936000694 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936000695 cyclase homology domain; Region: CHD; cd07302 698936000696 nucleotidyl binding site; other site 698936000697 metal binding site [ion binding]; metal-binding site 698936000698 dimer interface [polypeptide binding]; other site 698936000699 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698936000700 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698936000701 hinge; other site 698936000702 active site 698936000703 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 698936000704 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 698936000705 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698936000706 NAD binding site [chemical binding]; other site 698936000707 dimerization interface [polypeptide binding]; other site 698936000708 product binding site; other site 698936000709 substrate binding site [chemical binding]; other site 698936000710 zinc binding site [ion binding]; other site 698936000711 catalytic residues [active] 698936000712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5328 698936000713 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 698936000714 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698936000715 active site 698936000716 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698936000717 rRNA binding site [nucleotide binding]; other site 698936000718 predicted 30S ribosome binding site; other site 698936000719 Maf-like protein; Region: Maf; pfam02545 698936000720 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698936000721 active site 698936000722 dimer interface [polypeptide binding]; other site 698936000723 zinc-binding protein; Provisional; Region: PRK01343 698936000724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 698936000725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 698936000726 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 698936000727 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 698936000728 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 698936000729 active site 698936000730 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 698936000731 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 698936000732 putative deacylase active site [active] 698936000733 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952 698936000734 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 698936000735 short chain dehydrogenase; Validated; Region: PRK08324 698936000736 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 698936000737 active site 698936000738 Zn2+ binding site [ion binding]; other site 698936000739 intersubunit interface [polypeptide binding]; other site 698936000740 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 698936000741 putative NAD(P) binding site [chemical binding]; other site 698936000742 active site 698936000743 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698936000744 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 698936000745 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698936000746 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 698936000747 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 698936000748 ligand binding site [chemical binding]; other site 698936000749 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936000750 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936000751 Walker A/P-loop; other site 698936000752 ATP binding site [chemical binding]; other site 698936000753 Q-loop/lid; other site 698936000754 ABC transporter signature motif; other site 698936000755 Walker B; other site 698936000756 D-loop; other site 698936000757 H-loop/switch region; other site 698936000758 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936000759 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936000760 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936000761 TM-ABC transporter signature motif; other site 698936000762 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936000763 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936000764 TM-ABC transporter signature motif; other site 698936000765 Uncharacterized conserved protein [Function unknown]; Region: COG3254 698936000766 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698936000767 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 698936000768 N- and C-terminal domain interface [polypeptide binding]; other site 698936000769 putative active site [active] 698936000770 putative MgATP binding site [chemical binding]; other site 698936000771 putative catalytic site [active] 698936000772 metal binding site [ion binding]; metal-binding site 698936000773 putative carbohydrate binding site [chemical binding]; other site 698936000774 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 698936000775 heme-binding site [chemical binding]; other site 698936000776 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698936000777 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698936000778 dimer interface [polypeptide binding]; other site 698936000779 putative CheW interface [polypeptide binding]; other site 698936000780 STAS domain; Region: STAS_2; pfam13466 698936000781 Response regulator receiver domain; Region: Response_reg; pfam00072 698936000782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936000783 active site 698936000784 phosphorylation site [posttranslational modification] 698936000785 intermolecular recognition site; other site 698936000786 dimerization interface [polypeptide binding]; other site 698936000787 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 698936000788 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 698936000789 putative binding surface; other site 698936000790 active site 698936000791 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 698936000792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936000793 ATP binding site [chemical binding]; other site 698936000794 Mg2+ binding site [ion binding]; other site 698936000795 G-X-G motif; other site 698936000796 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 698936000797 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 698936000798 putative CheA interaction surface; other site 698936000799 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 698936000800 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 698936000801 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 698936000802 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 698936000803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936000804 active site 698936000805 phosphorylation site [posttranslational modification] 698936000806 intermolecular recognition site; other site 698936000807 dimerization interface [polypeptide binding]; other site 698936000808 CheB methylesterase; Region: CheB_methylest; pfam01339 698936000809 Response regulator receiver domain; Region: Response_reg; pfam00072 698936000810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936000811 active site 698936000812 phosphorylation site [posttranslational modification] 698936000813 intermolecular recognition site; other site 698936000814 dimerization interface [polypeptide binding]; other site 698936000815 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13497 698936000816 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 698936000817 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 698936000818 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698936000819 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 698936000820 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 698936000821 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 698936000822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936000823 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936000824 dimerization interface [polypeptide binding]; other site 698936000825 DNA binding residues [nucleotide binding] 698936000826 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936000827 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936000828 DNA binding residues [nucleotide binding] 698936000829 dimerization interface [polypeptide binding]; other site 698936000830 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 698936000831 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 698936000832 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 698936000833 FliG C-terminal domain; Region: FliG_C; pfam01706 698936000834 flagellar motor switch protein FliN; Region: fliN; TIGR02480 698936000835 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 698936000836 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 698936000837 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 698936000838 flagellar motor protein MotA; Validated; Region: PRK09110 698936000839 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698936000840 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698936000841 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 698936000842 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 698936000843 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 698936000844 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 698936000845 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698936000846 Walker A motif; other site 698936000847 ATP binding site [chemical binding]; other site 698936000848 Walker B motif; other site 698936000849 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 698936000850 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 698936000851 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 698936000852 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 698936000853 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 698936000854 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 698936000855 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 698936000856 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 698936000857 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 698936000858 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 698936000859 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 698936000860 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 698936000861 Uncharacterized conserved protein [Function unknown]; Region: COG3334 698936000862 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 698936000863 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 698936000864 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 698936000865 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 698936000866 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 698936000867 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 698936000868 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 698936000869 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 698936000870 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 698936000871 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 698936000872 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 698936000873 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 698936000874 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 698936000875 flagellin; Reviewed; Region: PRK12687 698936000876 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 698936000877 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 698936000878 flagellar motor protein MotB; Validated; Region: motB; PRK05996 698936000879 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 698936000880 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 698936000881 ligand binding site [chemical binding]; other site 698936000882 chemotaxis protein; Reviewed; Region: PRK12798 698936000883 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 698936000884 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 698936000885 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698936000886 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698936000887 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698936000888 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936000889 DNA binding site [nucleotide binding] 698936000890 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 698936000891 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 698936000892 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 698936000893 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 698936000894 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 698936000895 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 698936000896 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 698936000897 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 698936000898 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 698936000899 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 698936000900 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 698936000901 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 698936000902 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 698936000903 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 698936000904 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 698936000905 FHIPEP family; Region: FHIPEP; pfam00771 698936000906 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 698936000907 Rod binding protein; Region: Rod-binding; pfam10135 698936000908 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698936000909 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698936000910 active site 698936000911 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 698936000912 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698936000913 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698936000914 homodimer interface [polypeptide binding]; other site 698936000915 NADP binding site [chemical binding]; other site 698936000916 substrate binding site [chemical binding]; other site 698936000917 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936000918 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936000919 DNA binding site [nucleotide binding] 698936000920 domain linker motif; other site 698936000921 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 698936000922 ligand binding site [chemical binding]; other site 698936000923 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936000924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936000925 dimer interface [polypeptide binding]; other site 698936000926 conserved gate region; other site 698936000927 putative PBP binding loops; other site 698936000928 ABC-ATPase subunit interface; other site 698936000929 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936000930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936000931 dimer interface [polypeptide binding]; other site 698936000932 conserved gate region; other site 698936000933 putative PBP binding loops; other site 698936000934 ABC-ATPase subunit interface; other site 698936000935 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 698936000936 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698936000937 active site 698936000938 catalytic site [active] 698936000939 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936000940 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936000941 Walker A/P-loop; other site 698936000942 ATP binding site [chemical binding]; other site 698936000943 Q-loop/lid; other site 698936000944 ABC transporter signature motif; other site 698936000945 Walker B; other site 698936000946 D-loop; other site 698936000947 H-loop/switch region; other site 698936000948 TOBE domain; Region: TOBE_2; pfam08402 698936000949 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 698936000950 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 698936000951 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698936000952 6-phosphogluconate dehydratase; Region: edd; TIGR01196 698936000953 phosphogluconate dehydratase; Validated; Region: PRK09054 698936000954 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698936000955 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 698936000956 putative active site [active] 698936000957 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698936000958 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698936000959 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698936000960 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698936000961 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936000962 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698936000963 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698936000964 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698936000965 Predicted flavoproteins [General function prediction only]; Region: COG2081 698936000966 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936000967 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698936000968 dimerization interface [polypeptide binding]; other site 698936000969 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698936000970 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698936000971 dimer interface [polypeptide binding]; other site 698936000972 putative CheW interface [polypeptide binding]; other site 698936000973 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936000974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936000975 isocitrate lyase; Provisional; Region: PRK15063 698936000976 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 698936000977 tetramer interface [polypeptide binding]; other site 698936000978 active site 698936000979 Mg2+/Mn2+ binding site [ion binding]; other site 698936000980 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698936000981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936000982 non-specific DNA binding site [nucleotide binding]; other site 698936000983 salt bridge; other site 698936000984 sequence-specific DNA binding site [nucleotide binding]; other site 698936000985 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698936000986 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698936000987 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698936000988 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 698936000989 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698936000990 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698936000991 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 698936000992 Walker A/P-loop; other site 698936000993 ATP binding site [chemical binding]; other site 698936000994 Q-loop/lid; other site 698936000995 ABC transporter signature motif; other site 698936000996 Walker B; other site 698936000997 D-loop; other site 698936000998 H-loop/switch region; other site 698936000999 TOBE domain; Region: TOBE_2; pfam08402 698936001000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936001001 dimer interface [polypeptide binding]; other site 698936001002 conserved gate region; other site 698936001003 putative PBP binding loops; other site 698936001004 ABC-ATPase subunit interface; other site 698936001005 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936001006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936001007 dimer interface [polypeptide binding]; other site 698936001008 conserved gate region; other site 698936001009 putative PBP binding loops; other site 698936001010 ABC-ATPase subunit interface; other site 698936001011 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 698936001012 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 698936001013 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 698936001014 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 698936001015 acyl-activating enzyme (AAE) consensus motif; other site 698936001016 putative AMP binding site [chemical binding]; other site 698936001017 putative active site [active] 698936001018 putative CoA binding site [chemical binding]; other site 698936001019 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 698936001020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936001021 dimer interface [polypeptide binding]; other site 698936001022 conserved gate region; other site 698936001023 putative PBP binding loops; other site 698936001024 ABC-ATPase subunit interface; other site 698936001025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936001026 dimer interface [polypeptide binding]; other site 698936001027 conserved gate region; other site 698936001028 putative PBP binding loops; other site 698936001029 ABC-ATPase subunit interface; other site 698936001030 PAS domain S-box; Region: sensory_box; TIGR00229 698936001031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936001032 putative active site [active] 698936001033 heme pocket [chemical binding]; other site 698936001034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936001035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936001036 dimer interface [polypeptide binding]; other site 698936001037 phosphorylation site [posttranslational modification] 698936001038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936001039 ATP binding site [chemical binding]; other site 698936001040 Mg2+ binding site [ion binding]; other site 698936001041 G-X-G motif; other site 698936001042 Uncharacterized conserved protein [Function unknown]; Region: COG5490 698936001043 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 698936001044 classical (c) SDRs; Region: SDR_c; cd05233 698936001045 NAD(P) binding site [chemical binding]; other site 698936001046 active site 698936001047 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 698936001048 FAD binding domain; Region: FAD_binding_4; pfam01565 698936001049 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 698936001050 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936001051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936001052 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936001053 dimerization interface [polypeptide binding]; other site 698936001054 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 698936001055 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 698936001056 tetrameric interface [polypeptide binding]; other site 698936001057 NAD binding site [chemical binding]; other site 698936001058 catalytic residues [active] 698936001059 Predicted membrane protein [Function unknown]; Region: COG4269 698936001060 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 698936001061 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 698936001062 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698936001063 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 698936001064 Rrf2 family protein; Region: rrf2_super; TIGR00738 698936001065 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936001066 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 698936001067 peptide binding site [polypeptide binding]; other site 698936001068 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936001069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936001070 dimer interface [polypeptide binding]; other site 698936001071 conserved gate region; other site 698936001072 putative PBP binding loops; other site 698936001073 ABC-ATPase subunit interface; other site 698936001074 dipeptide transporter; Provisional; Region: PRK10913 698936001075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936001076 dimer interface [polypeptide binding]; other site 698936001077 conserved gate region; other site 698936001078 putative PBP binding loops; other site 698936001079 ABC-ATPase subunit interface; other site 698936001080 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936001081 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698936001082 Walker A/P-loop; other site 698936001083 ATP binding site [chemical binding]; other site 698936001084 Q-loop/lid; other site 698936001085 ABC transporter signature motif; other site 698936001086 Walker B; other site 698936001087 D-loop; other site 698936001088 H-loop/switch region; other site 698936001089 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936001090 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936001091 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698936001092 Walker A/P-loop; other site 698936001093 ATP binding site [chemical binding]; other site 698936001094 Q-loop/lid; other site 698936001095 ABC transporter signature motif; other site 698936001096 Walker B; other site 698936001097 D-loop; other site 698936001098 H-loop/switch region; other site 698936001099 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936001100 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 698936001101 homotrimer interaction site [polypeptide binding]; other site 698936001102 putative active site [active] 698936001103 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698936001104 two-component response regulator; Provisional; Region: PRK09191 698936001105 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698936001106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936001107 active site 698936001108 phosphorylation site [posttranslational modification] 698936001109 intermolecular recognition site; other site 698936001110 dimerization interface [polypeptide binding]; other site 698936001111 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936001112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698936001113 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936001114 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 698936001115 MgtC family; Region: MgtC; pfam02308 698936001116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 698936001117 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 698936001118 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 698936001119 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 698936001120 Chromate transporter; Region: Chromate_transp; pfam02417 698936001121 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698936001122 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698936001123 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 698936001124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936001125 S-adenosylmethionine binding site [chemical binding]; other site 698936001126 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936001127 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 698936001128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936001129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936001130 putative substrate translocation pore; other site 698936001131 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698936001132 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698936001133 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698936001134 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698936001135 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698936001136 active site 698936001137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5331 698936001138 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 698936001139 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 698936001140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936001141 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 698936001142 dimerization interface [polypeptide binding]; other site 698936001143 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698936001144 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 698936001145 tetramer interface [polypeptide binding]; other site 698936001146 heme binding pocket [chemical binding]; other site 698936001147 NADPH binding site [chemical binding]; other site 698936001148 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 698936001149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936001150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936001151 dimerization interface [polypeptide binding]; other site 698936001152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 698936001153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936001154 non-specific DNA binding site [nucleotide binding]; other site 698936001155 salt bridge; other site 698936001156 sequence-specific DNA binding site [nucleotide binding]; other site 698936001157 Uncharacterized conserved protein [Function unknown]; Region: COG5403 698936001158 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 698936001159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 698936001160 RNA methyltransferase, RsmE family; Region: TIGR00046 698936001161 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698936001162 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698936001163 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 698936001164 nudix motif; other site 698936001165 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936001166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936001167 DNA-binding site [nucleotide binding]; DNA binding site 698936001168 FCD domain; Region: FCD; pfam07729 698936001169 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4949 698936001170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936001171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936001172 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698936001173 putative effector binding pocket; other site 698936001174 dimerization interface [polypeptide binding]; other site 698936001175 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 698936001176 FAD binding domain; Region: FAD_binding_4; pfam01565 698936001177 FAD binding domain; Region: FAD_binding_4; pfam01565 698936001178 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 698936001179 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 698936001180 Cysteine-rich domain; Region: CCG; pfam02754 698936001181 Cysteine-rich domain; Region: CCG; pfam02754 698936001182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698936001183 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698936001184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698936001185 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698936001186 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 698936001187 Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953 698936001188 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 698936001189 Na binding site [ion binding]; other site 698936001190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 698936001191 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 698936001192 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698936001193 dimer interface [polypeptide binding]; other site 698936001194 motif 1; other site 698936001195 active site 698936001196 motif 2; other site 698936001197 motif 3; other site 698936001198 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698936001199 anticodon binding site; other site 698936001200 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 698936001201 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698936001202 motif 1; other site 698936001203 dimer interface [polypeptide binding]; other site 698936001204 active site 698936001205 motif 2; other site 698936001206 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698936001207 motif 3; other site 698936001208 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 698936001209 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 698936001210 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936001211 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 698936001212 C-terminal domain interface [polypeptide binding]; other site 698936001213 GSH binding site (G-site) [chemical binding]; other site 698936001214 dimer interface [polypeptide binding]; other site 698936001215 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 698936001216 dimer interface [polypeptide binding]; other site 698936001217 N-terminal domain interface [polypeptide binding]; other site 698936001218 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 698936001219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698936001220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936001221 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698936001222 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698936001223 ring oligomerisation interface [polypeptide binding]; other site 698936001224 ATP/Mg binding site [chemical binding]; other site 698936001225 stacking interactions; other site 698936001226 hinge regions; other site 698936001227 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698936001228 oligomerisation interface [polypeptide binding]; other site 698936001229 mobile loop; other site 698936001230 roof hairpin; other site 698936001231 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 698936001232 active site residue [active] 698936001233 Uncharacterized conserved protein [Function unknown]; Region: COG4275 698936001234 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698936001235 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 698936001236 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698936001237 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698936001238 active site 698936001239 Riboflavin kinase; Region: Flavokinase; smart00904 698936001240 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 698936001241 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698936001242 active site 698936001243 HIGH motif; other site 698936001244 nucleotide binding site [chemical binding]; other site 698936001245 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698936001246 active site 698936001247 KMSKS motif; other site 698936001248 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 698936001249 tRNA binding surface [nucleotide binding]; other site 698936001250 anticodon binding site; other site 698936001251 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698936001252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936001253 Coenzyme A binding pocket [chemical binding]; other site 698936001254 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698936001255 nucleoside/Zn binding site; other site 698936001256 dimer interface [polypeptide binding]; other site 698936001257 catalytic motif [active] 698936001258 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698936001259 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698936001260 RNA binding surface [nucleotide binding]; other site 698936001261 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698936001262 active site 698936001263 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 698936001264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936001265 S-adenosylmethionine binding site [chemical binding]; other site 698936001266 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 698936001267 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 698936001268 nucleophile elbow; other site 698936001269 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 698936001270 putative active site [active] 698936001271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 698936001272 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698936001273 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698936001274 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698936001275 TrkA-N domain; Region: TrkA_N; pfam02254 698936001276 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 698936001277 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698936001278 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698936001279 active site 698936001280 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 698936001281 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 698936001282 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 698936001283 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698936001284 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698936001285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936001286 motif II; other site 698936001287 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 698936001288 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 698936001289 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 698936001290 Helix-turn-helix domain; Region: HTH_28; pfam13518 698936001291 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698936001292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698936001293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 698936001294 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 698936001295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936001296 ATP binding site [chemical binding]; other site 698936001297 Mg2+ binding site [ion binding]; other site 698936001298 G-X-G motif; other site 698936001299 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 698936001300 ATP binding site [chemical binding]; other site 698936001301 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 698936001302 PAS fold; Region: PAS_4; pfam08448 698936001303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936001304 putative active site [active] 698936001305 heme pocket [chemical binding]; other site 698936001306 Response regulator receiver domain; Region: Response_reg; pfam00072 698936001307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936001308 active site 698936001309 phosphorylation site [posttranslational modification] 698936001310 intermolecular recognition site; other site 698936001311 dimerization interface [polypeptide binding]; other site 698936001312 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936001313 metal binding site [ion binding]; metal-binding site 698936001314 active site 698936001315 I-site; other site 698936001316 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698936001317 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698936001318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936001319 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 698936001320 dimerization interface [polypeptide binding]; other site 698936001321 substrate binding pocket [chemical binding]; other site 698936001322 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 698936001323 PRC-barrel domain; Region: PRC; pfam05239 698936001324 dihydroxy-acid dehydratase; Validated; Region: PRK06131 698936001325 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 698936001326 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 698936001327 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 698936001328 active site 698936001329 intersubunit interface [polypeptide binding]; other site 698936001330 catalytic residue [active] 698936001331 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 698936001332 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 698936001333 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936001334 classical (c) SDRs; Region: SDR_c; cd05233 698936001335 NAD(P) binding site [chemical binding]; other site 698936001336 active site 698936001337 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698936001338 Bacterial transcriptional regulator; Region: IclR; pfam01614 698936001339 transcriptional regulator TraR; Provisional; Region: PRK13870 698936001340 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698936001341 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936001342 DNA binding residues [nucleotide binding] 698936001343 dimerization interface [polypeptide binding]; other site 698936001344 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 698936001345 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698936001346 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936001347 DNA binding residues [nucleotide binding] 698936001348 dimerization interface [polypeptide binding]; other site 698936001349 Domain of unknown function DUF59; Region: DUF59; pfam01883 698936001350 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 698936001351 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698936001352 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698936001353 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 698936001354 Cl binding site [ion binding]; other site 698936001355 oligomer interface [polypeptide binding]; other site 698936001356 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 698936001357 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 698936001358 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 698936001359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 698936001360 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698936001361 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698936001362 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 698936001363 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 698936001364 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698936001365 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 698936001366 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 698936001367 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698936001368 RNA/DNA hybrid binding site [nucleotide binding]; other site 698936001369 active site 698936001370 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 698936001371 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698936001372 FeS/SAM binding site; other site 698936001373 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698936001374 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698936001375 active site 698936001376 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698936001377 MPT binding site; other site 698936001378 trimer interface [polypeptide binding]; other site 698936001379 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 698936001380 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698936001381 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 698936001382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936001383 TPR motif; other site 698936001384 binding surface 698936001385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936001386 binding surface 698936001387 TPR motif; other site 698936001388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936001389 binding surface 698936001390 TPR motif; other site 698936001391 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698936001392 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698936001393 substrate binding pocket [chemical binding]; other site 698936001394 chain length determination region; other site 698936001395 substrate-Mg2+ binding site; other site 698936001396 catalytic residues [active] 698936001397 aspartate-rich region 1; other site 698936001398 active site lid residues [active] 698936001399 aspartate-rich region 2; other site 698936001400 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 698936001401 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 698936001402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936001403 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 698936001404 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 698936001405 tandem repeat interface [polypeptide binding]; other site 698936001406 oligomer interface [polypeptide binding]; other site 698936001407 active site residues [active] 698936001408 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 698936001409 dimer interface [polypeptide binding]; other site 698936001410 motif 1; other site 698936001411 active site 698936001412 motif 2; other site 698936001413 motif 3; other site 698936001414 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 698936001415 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 698936001416 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 698936001417 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 698936001418 Uncharacterized conserved protein [Function unknown]; Region: COG1683 698936001419 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698936001420 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698936001421 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698936001422 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698936001423 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698936001424 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936001425 metal binding site [ion binding]; metal-binding site 698936001426 active site 698936001427 I-site; other site 698936001428 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698936001429 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698936001430 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698936001431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936001432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936001433 putative substrate translocation pore; other site 698936001434 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698936001435 Helix-turn-helix domain; Region: HTH_18; pfam12833 698936001436 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 698936001437 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 698936001438 UbiA prenyltransferase family; Region: UbiA; pfam01040 698936001439 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698936001440 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698936001441 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698936001442 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698936001443 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698936001444 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698936001445 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698936001446 FAD binding domain; Region: FAD_binding_4; pfam01565 698936001447 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698936001448 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 698936001449 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 698936001450 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 698936001451 [2Fe-2S] cluster binding site [ion binding]; other site 698936001452 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 698936001453 putative alpha subunit interface [polypeptide binding]; other site 698936001454 putative active site [active] 698936001455 putative substrate binding site [chemical binding]; other site 698936001456 Fe binding site [ion binding]; other site 698936001457 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698936001458 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 698936001459 FAD binding pocket [chemical binding]; other site 698936001460 FAD binding motif [chemical binding]; other site 698936001461 phosphate binding motif [ion binding]; other site 698936001462 beta-alpha-beta structure motif; other site 698936001463 NAD binding pocket [chemical binding]; other site 698936001464 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936001465 catalytic loop [active] 698936001466 iron binding site [ion binding]; other site 698936001467 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 698936001468 active site 698936001469 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 698936001470 BA14K-like protein; Region: BA14K; pfam07886 698936001471 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698936001472 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 698936001473 Cl binding site [ion binding]; other site 698936001474 oligomer interface [polypeptide binding]; other site 698936001475 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698936001476 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698936001477 active site 698936001478 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 698936001479 enoyl-CoA hydratase; Provisional; Region: PRK06688 698936001480 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698936001481 substrate binding site [chemical binding]; other site 698936001482 oxyanion hole (OAH) forming residues; other site 698936001483 trimer interface [polypeptide binding]; other site 698936001484 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 698936001485 Cache domain; Region: Cache_1; pfam02743 698936001486 HAMP domain; Region: HAMP; pfam00672 698936001487 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698936001488 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698936001489 dimer interface [polypeptide binding]; other site 698936001490 putative CheW interface [polypeptide binding]; other site 698936001491 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698936001492 TRAM domain; Region: TRAM; cl01282 698936001493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936001494 S-adenosylmethionine binding site [chemical binding]; other site 698936001495 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698936001496 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698936001497 RNA binding surface [nucleotide binding]; other site 698936001498 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 698936001499 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 698936001500 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 698936001501 TPP-binding site; other site 698936001502 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698936001503 PYR/PP interface [polypeptide binding]; other site 698936001504 dimer interface [polypeptide binding]; other site 698936001505 TPP binding site [chemical binding]; other site 698936001506 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698936001507 Pirin-related protein [General function prediction only]; Region: COG1741 698936001508 Pirin; Region: Pirin; pfam02678 698936001509 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 698936001510 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 698936001511 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 698936001512 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 698936001513 putative active site [active] 698936001514 Zn binding site [ion binding]; other site 698936001515 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698936001516 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 698936001517 NADP binding site [chemical binding]; other site 698936001518 dimer interface [polypeptide binding]; other site 698936001519 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698936001520 active site 698936001521 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698936001522 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 698936001523 dimer interface [polypeptide binding]; other site 698936001524 active site 698936001525 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 698936001526 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698936001527 acyl-activating enzyme (AAE) consensus motif; other site 698936001528 AMP binding site [chemical binding]; other site 698936001529 active site 698936001530 CoA binding site [chemical binding]; other site 698936001531 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 698936001532 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698936001533 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698936001534 Walker A/P-loop; other site 698936001535 ATP binding site [chemical binding]; other site 698936001536 Q-loop/lid; other site 698936001537 ABC transporter signature motif; other site 698936001538 Walker B; other site 698936001539 D-loop; other site 698936001540 H-loop/switch region; other site 698936001541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 698936001542 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 698936001543 protease TldD; Provisional; Region: tldD; PRK10735 698936001544 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698936001545 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698936001546 Sporulation related domain; Region: SPOR; pfam05036 698936001547 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698936001548 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 698936001549 putative active site [active] 698936001550 putative metal binding site [ion binding]; other site 698936001551 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 698936001552 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 698936001553 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 698936001554 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 698936001555 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698936001556 HSP70 interaction site [polypeptide binding]; other site 698936001557 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698936001558 substrate binding site [polypeptide binding]; other site 698936001559 dimer interface [polypeptide binding]; other site 698936001560 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 698936001561 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 698936001562 NAD binding site [chemical binding]; other site 698936001563 homotetramer interface [polypeptide binding]; other site 698936001564 homodimer interface [polypeptide binding]; other site 698936001565 substrate binding site [chemical binding]; other site 698936001566 active site 698936001567 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698936001568 catalytic core [active] 698936001569 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 698936001570 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698936001571 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698936001572 Tetramer interface [polypeptide binding]; other site 698936001573 active site 698936001574 FMN-binding site [chemical binding]; other site 698936001575 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698936001576 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698936001577 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 698936001578 dimerization interface [polypeptide binding]; other site 698936001579 active site 698936001580 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 698936001581 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00051 698936001582 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 698936001583 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698936001584 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 698936001585 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 698936001586 Subunit I/III interface [polypeptide binding]; other site 698936001587 D-pathway; other site 698936001588 Subunit I/VIIc interface [polypeptide binding]; other site 698936001589 Subunit I/IV interface [polypeptide binding]; other site 698936001590 Subunit I/II interface [polypeptide binding]; other site 698936001591 Low-spin heme (heme a) binding site [chemical binding]; other site 698936001592 Subunit I/VIIa interface [polypeptide binding]; other site 698936001593 Subunit I/VIa interface [polypeptide binding]; other site 698936001594 Dimer interface; other site 698936001595 Putative water exit pathway; other site 698936001596 Binuclear center (heme a3/CuB) [ion binding]; other site 698936001597 K-pathway; other site 698936001598 Subunit I/Vb interface [polypeptide binding]; other site 698936001599 Putative proton exit pathway; other site 698936001600 Subunit I/VIb interface; other site 698936001601 Subunit I/VIc interface [polypeptide binding]; other site 698936001602 Electron transfer pathway; other site 698936001603 Subunit I/VIIIb interface [polypeptide binding]; other site 698936001604 Subunit I/VIIb interface [polypeptide binding]; other site 698936001605 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 698936001606 UbiA prenyltransferase family; Region: UbiA; pfam01040 698936001607 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 698936001608 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 698936001609 Subunit III/VIIa interface [polypeptide binding]; other site 698936001610 Phospholipid binding site [chemical binding]; other site 698936001611 Subunit I/III interface [polypeptide binding]; other site 698936001612 Subunit III/VIb interface [polypeptide binding]; other site 698936001613 Subunit III/VIa interface; other site 698936001614 Subunit III/Vb interface [polypeptide binding]; other site 698936001615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 698936001616 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698936001617 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 698936001618 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 698936001619 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 698936001620 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 698936001621 putative active site [active] 698936001622 putative substrate binding site [chemical binding]; other site 698936001623 ATP binding site [chemical binding]; other site 698936001624 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 698936001625 RNA/DNA hybrid binding site [nucleotide binding]; other site 698936001626 active site 698936001627 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 698936001628 catalytic triad [active] 698936001629 dimer interface [polypeptide binding]; other site 698936001630 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 698936001631 hypothetical protein; Validated; Region: PRK00228 698936001632 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 698936001633 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 698936001634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936001635 PAS fold; Region: PAS_3; pfam08447 698936001636 putative active site [active] 698936001637 heme pocket [chemical binding]; other site 698936001638 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936001639 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936001640 metal binding site [ion binding]; metal-binding site 698936001641 active site 698936001642 I-site; other site 698936001643 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698936001644 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698936001645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698936001646 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 698936001647 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 698936001648 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 698936001649 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698936001650 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 698936001651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936001652 catalytic residue [active] 698936001653 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 698936001654 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 698936001655 dimerization interface [polypeptide binding]; other site 698936001656 ligand binding site [chemical binding]; other site 698936001657 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 698936001658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936001659 motif II; other site 698936001660 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936001661 dimerization interface [polypeptide binding]; other site 698936001662 putative DNA binding site [nucleotide binding]; other site 698936001663 putative Zn2+ binding site [ion binding]; other site 698936001664 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 698936001665 DNA methylase; Region: N6_N4_Mtase; pfam01555 698936001666 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 698936001667 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 698936001668 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 698936001669 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698936001670 minor groove reading motif; other site 698936001671 helix-hairpin-helix signature motif; other site 698936001672 substrate binding pocket [chemical binding]; other site 698936001673 active site 698936001674 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 698936001675 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 698936001676 DNA binding and oxoG recognition site [nucleotide binding] 698936001677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 698936001678 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698936001679 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698936001680 catalytic residues [active] 698936001681 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 698936001682 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698936001683 Walker A/P-loop; other site 698936001684 ATP binding site [chemical binding]; other site 698936001685 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698936001686 ABC transporter signature motif; other site 698936001687 Walker B; other site 698936001688 D-loop; other site 698936001689 H-loop/switch region; other site 698936001690 pyruvate phosphate dikinase; Provisional; Region: PRK09279 698936001691 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 698936001692 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698936001693 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698936001694 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 698936001695 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698936001696 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 698936001697 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 698936001698 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698936001699 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 698936001700 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 698936001701 CysD dimerization site [polypeptide binding]; other site 698936001702 G1 box; other site 698936001703 putative GEF interaction site [polypeptide binding]; other site 698936001704 GTP/Mg2+ binding site [chemical binding]; other site 698936001705 Switch I region; other site 698936001706 G2 box; other site 698936001707 G3 box; other site 698936001708 Switch II region; other site 698936001709 G4 box; other site 698936001710 G5 box; other site 698936001711 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 698936001712 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 698936001713 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 698936001714 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 698936001715 Active Sites [active] 698936001716 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 698936001717 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 698936001718 Active Sites [active] 698936001719 choline dehydrogenase; Validated; Region: PRK02106 698936001720 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698936001721 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 698936001722 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698936001723 NAD(P) binding site [chemical binding]; other site 698936001724 catalytic residues [active] 698936001725 Sulfatase; Region: Sulfatase; cl17466 698936001726 choline-sulfatase; Region: chol_sulfatase; TIGR03417 698936001727 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 698936001728 transcriptional regulator BetI; Validated; Region: PRK00767 698936001729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936001730 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 698936001731 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 698936001732 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698936001733 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698936001734 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936001735 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936001736 metal binding site [ion binding]; metal-binding site 698936001737 active site 698936001738 I-site; other site 698936001739 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698936001740 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 698936001741 NAD(P) binding site [chemical binding]; other site 698936001742 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 698936001743 L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448 698936001744 glutathionine S-transferase; Provisional; Region: PRK10542 698936001745 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 698936001746 C-terminal domain interface [polypeptide binding]; other site 698936001747 GSH binding site (G-site) [chemical binding]; other site 698936001748 dimer interface [polypeptide binding]; other site 698936001749 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 698936001750 dimer interface [polypeptide binding]; other site 698936001751 N-terminal domain interface [polypeptide binding]; other site 698936001752 substrate binding pocket (H-site) [chemical binding]; other site 698936001753 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698936001754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936001755 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 698936001756 dimerization interface [polypeptide binding]; other site 698936001757 substrate binding pocket [chemical binding]; other site 698936001758 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936001759 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 698936001760 putative C-terminal domain interface [polypeptide binding]; other site 698936001761 putative GSH binding site (G-site) [chemical binding]; other site 698936001762 putative dimer interface [polypeptide binding]; other site 698936001763 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 698936001764 dimer interface [polypeptide binding]; other site 698936001765 N-terminal domain interface [polypeptide binding]; other site 698936001766 putative substrate binding pocket (H-site) [chemical binding]; other site 698936001767 PAS fold; Region: PAS_4; pfam08448 698936001768 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 698936001769 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698936001770 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936001771 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936001772 metal binding site [ion binding]; metal-binding site 698936001773 active site 698936001774 I-site; other site 698936001775 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698936001776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698936001777 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698936001778 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698936001779 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936001780 putative Zn2+ binding site [ion binding]; other site 698936001781 putative DNA binding site [nucleotide binding]; other site 698936001782 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 698936001783 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698936001784 PhnA protein; Region: PhnA; pfam03831 698936001785 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 698936001786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 698936001787 Walker A motif; other site 698936001788 ATP binding site [chemical binding]; other site 698936001789 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936001790 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936001791 active site 698936001792 catalytic tetrad [active] 698936001793 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 698936001794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936001795 S-adenosylmethionine binding site [chemical binding]; other site 698936001796 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 698936001797 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936001798 motif II; other site 698936001799 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 698936001800 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698936001801 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 698936001802 putative NAD(P) binding site [chemical binding]; other site 698936001803 catalytic Zn binding site [ion binding]; other site 698936001804 structural Zn binding site [ion binding]; other site 698936001805 aminotransferase; Provisional; Region: PRK13356 698936001806 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698936001807 homodimer interface [polypeptide binding]; other site 698936001808 substrate-cofactor binding pocket; other site 698936001809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936001810 catalytic residue [active] 698936001811 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 698936001812 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936001813 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698936001814 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698936001815 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698936001816 Predicted transcriptional regulator [Transcription]; Region: COG2378 698936001817 HTH domain; Region: HTH_11; pfam08279 698936001818 WYL domain; Region: WYL; pfam13280 698936001819 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698936001820 Cytochrome c556 [Energy production and conversion]; Region: COG3909 698936001821 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698936001822 Cytochrome c; Region: Cytochrom_C; cl11414 698936001823 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698936001824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936001825 Coenzyme A binding pocket [chemical binding]; other site 698936001826 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 698936001827 DNA binding residues [nucleotide binding] 698936001828 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 698936001829 dimer interface [polypeptide binding]; other site 698936001830 putative metal binding site [ion binding]; other site 698936001831 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 698936001832 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 698936001833 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 698936001834 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 698936001835 Trp docking motif [polypeptide binding]; other site 698936001836 putative active site [active] 698936001837 Uncharacterized conserved protein [Function unknown]; Region: COG0397 698936001838 hypothetical protein; Validated; Region: PRK00029 698936001839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 698936001840 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 698936001841 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698936001842 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 698936001843 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 698936001844 putative metal binding site [ion binding]; other site 698936001845 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698936001846 active site 698936001847 metal binding site [ion binding]; metal-binding site 698936001848 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698936001849 Ligand Binding Site [chemical binding]; other site 698936001850 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 698936001851 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698936001852 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698936001853 methionine sulfoxide reductase B; Provisional; Region: PRK00222 698936001854 SelR domain; Region: SelR; pfam01641 698936001855 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 698936001856 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 698936001857 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698936001858 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698936001859 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 698936001860 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658 698936001861 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 698936001862 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698936001863 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 698936001864 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 698936001865 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 698936001866 Predicted transcriptional regulator [Transcription]; Region: COG4957 698936001867 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 698936001868 two-component sensor protein; Provisional; Region: cpxA; PRK09470 698936001869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936001870 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936001871 dimer interface [polypeptide binding]; other site 698936001872 phosphorylation site [posttranslational modification] 698936001873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936001874 ATP binding site [chemical binding]; other site 698936001875 Mg2+ binding site [ion binding]; other site 698936001876 G-X-G motif; other site 698936001877 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 698936001878 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698936001879 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698936001880 Uncharacterized conserved protein [Function unknown]; Region: COG5447 698936001881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 698936001882 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 698936001883 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 698936001884 Bacterial SH3 domain; Region: SH3_3; pfam08239 698936001885 Predicted integral membrane protein [Function unknown]; Region: COG5436 698936001886 Uncharacterized conserved protein [Function unknown]; Region: COG5402 698936001887 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698936001888 Transglycosylase; Region: Transgly; pfam00912 698936001889 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698936001890 hypothetical protein; Provisional; Region: PRK05170 698936001891 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 698936001892 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 698936001893 putative active site [active] 698936001894 putative NTP binding site [chemical binding]; other site 698936001895 putative nucleic acid binding site [nucleotide binding]; other site 698936001896 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 698936001897 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698936001898 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698936001899 Protein of unknown function (DUF419); Region: DUF419; pfam04237 698936001900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698936001901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936001902 active site 698936001903 phosphorylation site [posttranslational modification] 698936001904 intermolecular recognition site; other site 698936001905 dimerization interface [polypeptide binding]; other site 698936001906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936001907 DNA binding site [nucleotide binding] 698936001908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936001909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936001910 ATP binding site [chemical binding]; other site 698936001911 Mg2+ binding site [ion binding]; other site 698936001912 G-X-G motif; other site 698936001913 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 698936001914 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 698936001915 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 698936001916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936001917 binding surface 698936001918 TPR motif; other site 698936001919 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 698936001920 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 698936001921 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 698936001922 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698936001923 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698936001924 protein binding site [polypeptide binding]; other site 698936001925 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698936001926 protein binding site [polypeptide binding]; other site 698936001927 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698936001928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936001929 active site 698936001930 phosphorylation site [posttranslational modification] 698936001931 intermolecular recognition site; other site 698936001932 dimerization interface [polypeptide binding]; other site 698936001933 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936001934 DNA binding site [nucleotide binding] 698936001935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936001936 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698936001937 dimerization interface [polypeptide binding]; other site 698936001938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936001939 dimer interface [polypeptide binding]; other site 698936001940 phosphorylation site [posttranslational modification] 698936001941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936001942 ATP binding site [chemical binding]; other site 698936001943 Mg2+ binding site [ion binding]; other site 698936001944 G-X-G motif; other site 698936001945 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 698936001946 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698936001947 metal binding triad; other site 698936001948 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698936001949 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698936001950 metal binding triad; other site 698936001951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936001952 PAS fold; Region: PAS_3; pfam08447 698936001953 putative active site [active] 698936001954 heme pocket [chemical binding]; other site 698936001955 PAS fold; Region: PAS_7; pfam12860 698936001956 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936001957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936001958 dimer interface [polypeptide binding]; other site 698936001959 phosphorylation site [posttranslational modification] 698936001960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936001961 ATP binding site [chemical binding]; other site 698936001962 Mg2+ binding site [ion binding]; other site 698936001963 G-X-G motif; other site 698936001964 aminopeptidase N; Provisional; Region: pepN; PRK14015 698936001965 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 698936001966 active site 698936001967 Zn binding site [ion binding]; other site 698936001968 EamA-like transporter family; Region: EamA; pfam00892 698936001969 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698936001970 EamA-like transporter family; Region: EamA; pfam00892 698936001971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936001972 putative MFS family transporter protein; Provisional; Region: PRK03633 698936001973 putative substrate translocation pore; other site 698936001974 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 698936001975 Fe-S cluster binding site [ion binding]; other site 698936001976 active site 698936001977 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 698936001978 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 698936001979 nucleotide binding site [chemical binding]; other site 698936001980 putative NEF/HSP70 interaction site [polypeptide binding]; other site 698936001981 SBD interface [polypeptide binding]; other site 698936001982 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 698936001983 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936001984 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 698936001985 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 698936001986 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698936001987 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698936001988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936001989 dimer interface [polypeptide binding]; other site 698936001990 conserved gate region; other site 698936001991 putative PBP binding loops; other site 698936001992 ABC-ATPase subunit interface; other site 698936001993 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 698936001994 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 698936001995 putative NAD(P) binding site [chemical binding]; other site 698936001996 dimer interface [polypeptide binding]; other site 698936001997 Predicted transcriptional regulators [Transcription]; Region: COG1733 698936001998 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 698936001999 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698936002000 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698936002001 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 698936002002 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 698936002003 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698936002004 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 698936002005 Ligand binding site; other site 698936002006 Putative Catalytic site; other site 698936002007 DXD motif; other site 698936002008 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 698936002009 AMP nucleosidase; Provisional; Region: PRK08292 698936002010 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 698936002011 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 698936002012 Uncharacterized conserved protein [Function unknown]; Region: COG1742 698936002013 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 698936002014 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 698936002015 C-terminal domain interface [polypeptide binding]; other site 698936002016 GSH binding site (G-site) [chemical binding]; other site 698936002017 dimer interface [polypeptide binding]; other site 698936002018 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 698936002019 N-terminal domain interface [polypeptide binding]; other site 698936002020 putative dimer interface [polypeptide binding]; other site 698936002021 active site 698936002022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 698936002023 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 698936002024 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 698936002025 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936002026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936002027 homodimer interface [polypeptide binding]; other site 698936002028 catalytic residue [active] 698936002029 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 698936002030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936002031 sequence-specific DNA binding site [nucleotide binding]; other site 698936002032 salt bridge; other site 698936002033 Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549 698936002034 Porin subfamily; Region: Porin_2; pfam02530 698936002035 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 698936002036 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698936002037 active site 698936002038 DNA binding site [nucleotide binding] 698936002039 Int/Topo IB signature motif; other site 698936002040 Porin subfamily; Region: Porin_2; pfam02530 698936002041 CopC domain; Region: CopC; cl01012 698936002042 BA14K-like protein; Region: BA14K; pfam07886 698936002043 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 698936002044 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698936002045 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698936002046 catalytic residue [active] 698936002047 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698936002048 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698936002049 dimer interface [polypeptide binding]; other site 698936002050 active site 698936002051 catalytic residue [active] 698936002052 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698936002053 SmpB-tmRNA interface; other site 698936002054 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698936002055 LabA_like proteins; Region: LabA; cd10911 698936002056 putative metal binding site [ion binding]; other site 698936002057 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 698936002058 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698936002059 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698936002060 Zn2+ binding site [ion binding]; other site 698936002061 Mg2+ binding site [ion binding]; other site 698936002062 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698936002063 synthetase active site [active] 698936002064 NTP binding site [chemical binding]; other site 698936002065 metal binding site [ion binding]; metal-binding site 698936002066 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698936002067 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698936002068 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 698936002069 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 698936002070 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 698936002071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 698936002072 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698936002073 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698936002074 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698936002075 Catalytic site [active] 698936002076 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698936002077 ribonuclease III; Reviewed; Region: PRK12371 698936002078 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698936002079 dimerization interface [polypeptide binding]; other site 698936002080 active site 698936002081 metal binding site [ion binding]; metal-binding site 698936002082 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698936002083 dsRNA binding site [nucleotide binding]; other site 698936002084 GTPase Era; Reviewed; Region: era; PRK00089 698936002085 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698936002086 G1 box; other site 698936002087 GTP/Mg2+ binding site [chemical binding]; other site 698936002088 Switch I region; other site 698936002089 G2 box; other site 698936002090 Switch II region; other site 698936002091 G3 box; other site 698936002092 G4 box; other site 698936002093 G5 box; other site 698936002094 KH domain; Region: KH_2; pfam07650 698936002095 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 698936002096 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698936002097 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 698936002098 ArsC family; Region: ArsC; pfam03960 698936002099 catalytic residues [active] 698936002100 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 698936002101 amphipathic channel; other site 698936002102 Asn-Pro-Ala signature motifs; other site 698936002103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936002104 dimerization interface [polypeptide binding]; other site 698936002105 putative DNA binding site [nucleotide binding]; other site 698936002106 putative Zn2+ binding site [ion binding]; other site 698936002107 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 698936002108 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698936002109 putative active site [active] 698936002110 catalytic site [active] 698936002111 putative metal binding site [ion binding]; other site 698936002112 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698936002113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936002114 S-adenosylmethionine binding site [chemical binding]; other site 698936002115 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698936002116 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698936002117 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698936002118 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 698936002119 RNA binding site [nucleotide binding]; other site 698936002120 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 698936002121 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698936002122 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698936002123 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698936002124 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936002125 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 698936002126 putative NAD(P) binding site [chemical binding]; other site 698936002127 active site 698936002128 putative substrate binding site [chemical binding]; other site 698936002129 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936002130 dimerization interface [polypeptide binding]; other site 698936002131 putative DNA binding site [nucleotide binding]; other site 698936002132 putative Zn2+ binding site [ion binding]; other site 698936002133 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698936002134 hydrophobic ligand binding site; other site 698936002135 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698936002136 active site 698936002137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698936002138 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698936002139 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 698936002140 Recombination protein O N terminal; Region: RecO_N; pfam11967 698936002141 Recombination protein O C terminal; Region: RecO_C; pfam02565 698936002142 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 698936002143 Predicted membrane protein [Function unknown]; Region: COG5373 698936002144 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 698936002145 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698936002146 Zn2+ binding site [ion binding]; other site 698936002147 Mg2+ binding site [ion binding]; other site 698936002148 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 698936002149 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 698936002150 MOSC domain; Region: MOSC; pfam03473 698936002151 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 698936002152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936002153 putative substrate translocation pore; other site 698936002154 quinolinate synthetase; Provisional; Region: PRK09375 698936002155 L-aspartate oxidase; Provisional; Region: PRK07512 698936002156 L-aspartate oxidase; Provisional; Region: PRK06175 698936002157 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698936002158 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 698936002159 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 698936002160 dimerization interface [polypeptide binding]; other site 698936002161 active site 698936002162 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 698936002163 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 698936002164 E-class dimer interface [polypeptide binding]; other site 698936002165 P-class dimer interface [polypeptide binding]; other site 698936002166 active site 698936002167 Cu2+ binding site [ion binding]; other site 698936002168 Zn2+ binding site [ion binding]; other site 698936002169 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 698936002170 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936002171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936002172 Walker A/P-loop; other site 698936002173 ATP binding site [chemical binding]; other site 698936002174 Q-loop/lid; other site 698936002175 ABC transporter signature motif; other site 698936002176 Walker B; other site 698936002177 D-loop; other site 698936002178 H-loop/switch region; other site 698936002179 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 698936002180 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936002181 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936002182 ACP:hemolysin acyltransferase (hemolysin-activating protein) [Posttranslational modification, protein turnover, chaperones]; Region: HlyC; COG2994 698936002183 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 698936002184 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 698936002185 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 698936002186 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 698936002187 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698936002188 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698936002189 Predicted secreted protein [Function unknown]; Region: COG5451 698936002190 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 698936002191 nudix motif; other site 698936002192 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698936002193 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698936002194 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698936002195 active site 698936002196 HIGH motif; other site 698936002197 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698936002198 KMSKS motif; other site 698936002199 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698936002200 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698936002201 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698936002202 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698936002203 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698936002204 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 698936002205 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 698936002206 active site 698936002207 catalytic residues [active] 698936002208 metal binding site [ion binding]; metal-binding site 698936002209 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698936002210 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698936002211 EamA-like transporter family; Region: EamA; cl17759 698936002212 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698936002213 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 698936002214 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 698936002215 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698936002216 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936002217 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 698936002218 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 698936002219 Walker A/P-loop; other site 698936002220 ATP binding site [chemical binding]; other site 698936002221 Q-loop/lid; other site 698936002222 ABC transporter signature motif; other site 698936002223 Walker B; other site 698936002224 D-loop; other site 698936002225 H-loop/switch region; other site 698936002226 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 698936002227 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 698936002228 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 698936002229 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698936002230 classical (c) SDRs; Region: SDR_c; cd05233 698936002231 NAD(P) binding site [chemical binding]; other site 698936002232 active site 698936002233 amidophosphoribosyltransferase; Provisional; Region: PRK09123 698936002234 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698936002235 active site 698936002236 tetramer interface [polypeptide binding]; other site 698936002237 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698936002238 active site 698936002239 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 698936002240 Colicin V production protein; Region: Colicin_V; pfam02674 698936002241 DNA repair protein RadA; Provisional; Region: PRK11823 698936002242 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 698936002243 Walker A motif/ATP binding site; other site 698936002244 ATP binding site [chemical binding]; other site 698936002245 Walker B motif; other site 698936002246 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698936002247 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 698936002248 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698936002249 active site 698936002250 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698936002251 dimer interface [polypeptide binding]; other site 698936002252 substrate binding site [chemical binding]; other site 698936002253 catalytic residues [active] 698936002254 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698936002255 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698936002256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936002257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936002258 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698936002259 Predicted membrane protein [Function unknown]; Region: COG4541 698936002260 replicative DNA helicase; Provisional; Region: PRK09165 698936002261 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698936002262 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698936002263 Walker A motif; other site 698936002264 ATP binding site [chemical binding]; other site 698936002265 Walker B motif; other site 698936002266 DNA binding loops [nucleotide binding] 698936002267 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698936002268 MarR family; Region: MarR_2; pfam12802 698936002269 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698936002270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936002271 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 698936002272 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936002273 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936002274 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698936002275 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698936002276 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698936002277 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 698936002278 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698936002279 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 698936002280 dimerization interface [polypeptide binding]; other site 698936002281 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936002282 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936002283 active site 698936002284 catalytic tetrad [active] 698936002285 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698936002286 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698936002287 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 698936002288 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 698936002289 NAD(P) binding site [chemical binding]; other site 698936002290 homotetramer interface [polypeptide binding]; other site 698936002291 homodimer interface [polypeptide binding]; other site 698936002292 active site 698936002293 acyl carrier protein; Provisional; Region: acpP; PRK00982 698936002294 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 698936002295 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 698936002296 dimer interface [polypeptide binding]; other site 698936002297 active site 698936002298 YceG-like family; Region: YceG; pfam02618 698936002299 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698936002300 dimerization interface [polypeptide binding]; other site 698936002301 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 698936002302 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 698936002303 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 698936002304 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698936002305 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698936002306 catalytic site [active] 698936002307 G-X2-G-X-G-K; other site 698936002308 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698936002309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936002310 S-adenosylmethionine binding site [chemical binding]; other site 698936002311 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 698936002312 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 698936002313 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 698936002314 SurA N-terminal domain; Region: SurA_N; pfam09312 698936002315 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 698936002316 Organic solvent tolerance protein; Region: OstA_C; pfam04453 698936002317 Predicted permeases [General function prediction only]; Region: COG0795 698936002318 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 698936002319 Predicted permeases [General function prediction only]; Region: COG0795 698936002320 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 698936002321 multifunctional aminopeptidase A; Provisional; Region: PRK00913 698936002322 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698936002323 interface (dimer of trimers) [polypeptide binding]; other site 698936002324 Substrate-binding/catalytic site; other site 698936002325 Zn-binding sites [ion binding]; other site 698936002326 DNA polymerase III subunit chi; Validated; Region: PRK05728 698936002327 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936002328 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936002329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936002330 Coenzyme A binding pocket [chemical binding]; other site 698936002331 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698936002332 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698936002333 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698936002334 ABC transporter; Region: ABC_tran_2; pfam12848 698936002335 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698936002336 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 698936002337 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698936002338 acyl-activating enzyme (AAE) consensus motif; other site 698936002339 AMP binding site [chemical binding]; other site 698936002340 active site 698936002341 CoA binding site [chemical binding]; other site 698936002342 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 698936002343 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698936002344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 698936002345 DinB superfamily; Region: DinB_2; pfam12867 698936002346 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 698936002347 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936002348 putative C-terminal domain interface [polypeptide binding]; other site 698936002349 putative GSH binding site (G-site) [chemical binding]; other site 698936002350 putative dimer interface [polypeptide binding]; other site 698936002351 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 698936002352 putative N-terminal domain interface [polypeptide binding]; other site 698936002353 putative dimer interface [polypeptide binding]; other site 698936002354 putative substrate binding pocket (H-site) [chemical binding]; other site 698936002355 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698936002356 active site 698936002357 multimer interface [polypeptide binding]; other site 698936002358 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 698936002359 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 698936002360 CGNR zinc finger; Region: zf-CGNR; pfam11706 698936002361 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 698936002362 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936002363 TM-ABC transporter signature motif; other site 698936002364 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698936002365 MoaE homodimer interface [polypeptide binding]; other site 698936002366 MoaD interaction [polypeptide binding]; other site 698936002367 active site residues [active] 698936002368 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 698936002369 MoaE interaction surface [polypeptide binding]; other site 698936002370 MoeB interaction surface [polypeptide binding]; other site 698936002371 thiocarboxylated glycine; other site 698936002372 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698936002373 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698936002374 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698936002375 GIY-YIG motif/motif A; other site 698936002376 active site 698936002377 catalytic site [active] 698936002378 putative DNA binding site [nucleotide binding]; other site 698936002379 metal binding site [ion binding]; metal-binding site 698936002380 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698936002381 short chain dehydrogenase; Provisional; Region: PRK09134 698936002382 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 698936002383 NADP binding site [chemical binding]; other site 698936002384 substrate binding pocket [chemical binding]; other site 698936002385 active site 698936002386 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 698936002387 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936002388 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 698936002389 putative C-terminal domain interface [polypeptide binding]; other site 698936002390 putative GSH binding site (G-site) [chemical binding]; other site 698936002391 putative dimer interface [polypeptide binding]; other site 698936002392 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 698936002393 N-terminal domain interface [polypeptide binding]; other site 698936002394 dimer interface [polypeptide binding]; other site 698936002395 putative substrate binding pocket (H-site) [chemical binding]; other site 698936002396 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 698936002397 B1 nucleotide binding pocket [chemical binding]; other site 698936002398 B2 nucleotide binding pocket [chemical binding]; other site 698936002399 CAS motifs; other site 698936002400 active site 698936002401 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 698936002402 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 698936002403 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 698936002404 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 698936002405 putative [4Fe-4S] binding site [ion binding]; other site 698936002406 putative molybdopterin cofactor binding site [chemical binding]; other site 698936002407 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 698936002408 putative molybdopterin cofactor binding site; other site 698936002409 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 698936002410 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698936002411 dimer interface [polypeptide binding]; other site 698936002412 ADP-ribose binding site [chemical binding]; other site 698936002413 active site 698936002414 nudix motif; other site 698936002415 metal binding site [ion binding]; metal-binding site 698936002416 Predicted integral membrane protein [Function unknown]; Region: COG0392 698936002417 Uncharacterized conserved protein [Function unknown]; Region: COG2898 698936002418 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 698936002419 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 698936002420 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 698936002421 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698936002422 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698936002423 active site 698936002424 substrate binding site [chemical binding]; other site 698936002425 cosubstrate binding site; other site 698936002426 catalytic site [active] 698936002427 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698936002428 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698936002429 dimerization interface [polypeptide binding]; other site 698936002430 putative ATP binding site [chemical binding]; other site 698936002431 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698936002432 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698936002433 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 698936002434 hypothetical protein; Validated; Region: PRK09087 698936002435 polyphosphate kinase; Provisional; Region: PRK05443 698936002436 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 698936002437 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 698936002438 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 698936002439 putative domain interface [polypeptide binding]; other site 698936002440 putative active site [active] 698936002441 catalytic site [active] 698936002442 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 698936002443 putative domain interface [polypeptide binding]; other site 698936002444 putative active site [active] 698936002445 catalytic site [active] 698936002446 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 698936002447 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698936002448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 698936002449 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936002450 cyclase homology domain; Region: CHD; cd07302 698936002451 nucleotidyl binding site; other site 698936002452 metal binding site [ion binding]; metal-binding site 698936002453 dimer interface [polypeptide binding]; other site 698936002454 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698936002455 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698936002456 catalytic site [active] 698936002457 putative active site [active] 698936002458 putative substrate binding site [chemical binding]; other site 698936002459 HRDC domain; Region: HRDC; pfam00570 698936002460 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 698936002461 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698936002462 Multicopper oxidase; Region: Cu-oxidase; pfam00394 698936002463 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 698936002464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936002465 putative substrate translocation pore; other site 698936002466 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698936002467 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698936002468 dimer interface [polypeptide binding]; other site 698936002469 anticodon binding site; other site 698936002470 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698936002471 homodimer interface [polypeptide binding]; other site 698936002472 motif 1; other site 698936002473 active site 698936002474 motif 2; other site 698936002475 GAD domain; Region: GAD; pfam02938 698936002476 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698936002477 active site 698936002478 motif 3; other site 698936002479 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 698936002480 active site 698936002481 catalytic residue [active] 698936002482 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698936002483 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698936002484 ring oligomerisation interface [polypeptide binding]; other site 698936002485 ATP/Mg binding site [chemical binding]; other site 698936002486 stacking interactions; other site 698936002487 hinge regions; other site 698936002488 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 698936002489 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698936002490 CAP-like domain; other site 698936002491 active site 698936002492 primary dimer interface [polypeptide binding]; other site 698936002493 EamA-like transporter family; Region: EamA; cl17759 698936002494 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 698936002495 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 698936002496 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 698936002497 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 698936002498 Predicted membrane protein/domain [Function unknown]; Region: COG1714 698936002499 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 698936002500 dimer interface [polypeptide binding]; other site 698936002501 allosteric magnesium binding site [ion binding]; other site 698936002502 active site 698936002503 aspartate-rich active site metal binding site; other site 698936002504 Schiff base residues; other site 698936002505 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698936002506 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 698936002507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 698936002508 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698936002509 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698936002510 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698936002511 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698936002512 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698936002513 dimer interface [polypeptide binding]; other site 698936002514 active site 698936002515 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698936002516 folate binding site [chemical binding]; other site 698936002517 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698936002518 ATP cone domain; Region: ATP-cone; pfam03477 698936002519 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698936002520 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698936002521 catalytic motif [active] 698936002522 Zn binding site [ion binding]; other site 698936002523 RibD C-terminal domain; Region: RibD_C; cl17279 698936002524 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698936002525 Lumazine binding domain; Region: Lum_binding; pfam00677 698936002526 Lumazine binding domain; Region: Lum_binding; pfam00677 698936002527 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698936002528 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 698936002529 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698936002530 homopentamer interface [polypeptide binding]; other site 698936002531 active site 698936002532 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698936002533 putative RNA binding site [nucleotide binding]; other site 698936002534 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 698936002535 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 698936002536 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 698936002537 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 698936002538 Uncharacterized conserved protein [Function unknown]; Region: COG5452 698936002539 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 698936002540 putative phosphate acyltransferase; Provisional; Region: PRK05331 698936002541 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 698936002542 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 698936002543 dimer interface [polypeptide binding]; other site 698936002544 active site 698936002545 CoA binding pocket [chemical binding]; other site 698936002546 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 698936002547 IHF dimer interface [polypeptide binding]; other site 698936002548 IHF - DNA interface [nucleotide binding]; other site 698936002549 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 698936002550 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698936002551 DNA binding residues [nucleotide binding] 698936002552 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698936002553 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936002554 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 698936002555 O-Antigen ligase; Region: Wzy_C; pfam04932 698936002556 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 698936002557 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 698936002558 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698936002559 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936002560 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 698936002561 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 698936002562 SLBB domain; Region: SLBB; pfam10531 698936002563 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 698936002564 Chain length determinant protein; Region: Wzz; cl15801 698936002565 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 698936002566 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 698936002567 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 698936002568 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 698936002569 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 698936002570 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698936002571 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 698936002572 trimer interface [polypeptide binding]; other site 698936002573 active site 698936002574 substrate binding site [chemical binding]; other site 698936002575 CoA binding site [chemical binding]; other site 698936002576 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698936002577 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 698936002578 active site 698936002579 metal binding site [ion binding]; metal-binding site 698936002580 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 698936002581 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698936002582 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 698936002583 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 698936002584 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698936002585 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 698936002586 agmatinase; Region: agmatinase; TIGR01230 698936002587 oligomer interface [polypeptide binding]; other site 698936002588 putative active site [active] 698936002589 Mn binding site [ion binding]; other site 698936002590 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698936002591 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698936002592 23S rRNA interface [nucleotide binding]; other site 698936002593 L3 interface [polypeptide binding]; other site 698936002594 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698936002595 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 698936002596 CoenzymeA binding site [chemical binding]; other site 698936002597 subunit interaction site [polypeptide binding]; other site 698936002598 PHB binding site; other site 698936002599 enoyl-CoA hydratase; Validated; Region: PRK08139 698936002600 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698936002601 substrate binding site [chemical binding]; other site 698936002602 oxyanion hole (OAH) forming residues; other site 698936002603 trimer interface [polypeptide binding]; other site 698936002604 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 698936002605 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 698936002606 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 698936002607 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698936002608 homodimer interface [polypeptide binding]; other site 698936002609 substrate-cofactor binding pocket; other site 698936002610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936002611 catalytic residue [active] 698936002612 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 698936002613 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 698936002614 Cytochrome P450; Region: p450; cl12078 698936002615 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 698936002616 putative catalytic site [active] 698936002617 putative metal binding site [ion binding]; other site 698936002618 putative phosphate binding site [ion binding]; other site 698936002619 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 698936002620 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 698936002621 putative active site [active] 698936002622 catalytic site [active] 698936002623 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 698936002624 putative active site [active] 698936002625 catalytic site [active] 698936002626 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 698936002627 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698936002628 oligomer interface [polypeptide binding]; other site 698936002629 active site residues [active] 698936002630 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698936002631 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 698936002632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936002633 Walker A motif; other site 698936002634 ATP binding site [chemical binding]; other site 698936002635 Walker B motif; other site 698936002636 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698936002637 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 698936002638 Found in ATP-dependent protease La (LON); Region: LON; smart00464 698936002639 Found in ATP-dependent protease La (LON); Region: LON; smart00464 698936002640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936002641 Walker A motif; other site 698936002642 ATP binding site [chemical binding]; other site 698936002643 Walker B motif; other site 698936002644 arginine finger; other site 698936002645 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 698936002646 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 698936002647 IHF dimer interface [polypeptide binding]; other site 698936002648 IHF - DNA interface [nucleotide binding]; other site 698936002649 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 698936002650 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698936002651 MarR family; Region: MarR; pfam01047 698936002652 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698936002653 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698936002654 active site 698936002655 metal binding site [ion binding]; metal-binding site 698936002656 DNA binding site [nucleotide binding] 698936002657 Uncharacterized conserved protein [Function unknown]; Region: COG4717 698936002658 P-loop containing region of AAA domain; Region: AAA_29; cl17516 698936002659 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 698936002660 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 698936002661 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 698936002662 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 698936002663 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 698936002664 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 698936002665 NADH dehydrogenase subunit D; Validated; Region: PRK06075 698936002666 NADH dehydrogenase subunit E; Validated; Region: PRK07539 698936002667 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 698936002668 putative dimer interface [polypeptide binding]; other site 698936002669 [2Fe-2S] cluster binding site [ion binding]; other site 698936002670 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 698936002671 SLBB domain; Region: SLBB; pfam10531 698936002672 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 698936002673 Uncharacterized conserved protein [Function unknown]; Region: COG3743 698936002674 NADH dehydrogenase subunit G; Validated; Region: PRK09130 698936002675 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936002676 catalytic loop [active] 698936002677 iron binding site [ion binding]; other site 698936002678 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 698936002679 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 698936002680 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 698936002681 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 698936002682 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 698936002683 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 698936002684 4Fe-4S binding domain; Region: Fer4; pfam00037 698936002685 4Fe-4S binding domain; Region: Fer4; pfam00037 698936002686 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 698936002687 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 698936002688 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 698936002689 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 698936002690 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 698936002691 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 698936002692 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698936002693 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 698936002694 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698936002695 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 698936002696 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698936002697 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698936002698 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 698936002699 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 698936002700 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698936002701 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698936002702 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698936002703 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936002704 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698936002705 dimer interface [polypeptide binding]; other site 698936002706 substrate binding site [chemical binding]; other site 698936002707 metal binding site [ion binding]; metal-binding site 698936002708 Predicted secreted protein [Function unknown]; Region: COG5454 698936002709 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698936002710 oligomeric interface; other site 698936002711 putative active site [active] 698936002712 homodimer interface [polypeptide binding]; other site 698936002713 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 698936002714 prolyl-tRNA synthetase; Provisional; Region: PRK12325 698936002715 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698936002716 dimer interface [polypeptide binding]; other site 698936002717 motif 1; other site 698936002718 active site 698936002719 motif 2; other site 698936002720 motif 3; other site 698936002721 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698936002722 anticodon binding site; other site 698936002723 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 698936002724 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698936002725 FtsX-like permease family; Region: FtsX; pfam02687 698936002726 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698936002727 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698936002728 Walker A/P-loop; other site 698936002729 ATP binding site [chemical binding]; other site 698936002730 Q-loop/lid; other site 698936002731 ABC transporter signature motif; other site 698936002732 Walker B; other site 698936002733 D-loop; other site 698936002734 H-loop/switch region; other site 698936002735 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 698936002736 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 698936002737 putative active site [active] 698936002738 putative PHP Thumb interface [polypeptide binding]; other site 698936002739 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698936002740 generic binding surface II; other site 698936002741 generic binding surface I; other site 698936002742 hypothetical protein; Provisional; Region: PRK06132 698936002743 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698936002744 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698936002745 DNA polymerase IV; Provisional; Region: PRK02794 698936002746 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698936002747 active site 698936002748 DNA binding site [nucleotide binding] 698936002749 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 698936002750 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698936002751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936002752 active site 698936002753 phosphorylation site [posttranslational modification] 698936002754 intermolecular recognition site; other site 698936002755 dimerization interface [polypeptide binding]; other site 698936002756 response regulator PleD; Reviewed; Region: pleD; PRK09581 698936002757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936002758 active site 698936002759 phosphorylation site [posttranslational modification] 698936002760 intermolecular recognition site; other site 698936002761 dimerization interface [polypeptide binding]; other site 698936002762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936002763 active site 698936002764 phosphorylation site [posttranslational modification] 698936002765 intermolecular recognition site; other site 698936002766 dimerization interface [polypeptide binding]; other site 698936002767 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936002768 metal binding site [ion binding]; metal-binding site 698936002769 active site 698936002770 I-site; other site 698936002771 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698936002772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936002773 putative substrate translocation pore; other site 698936002774 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936002775 hypothetical protein; Provisional; Region: PRK05978 698936002776 ribonuclease R; Region: RNase_R; TIGR02063 698936002777 RNB domain; Region: RNB; pfam00773 698936002778 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 698936002779 RNA binding site [nucleotide binding]; other site 698936002780 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 698936002781 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698936002782 active site 698936002783 interdomain interaction site; other site 698936002784 putative metal-binding site [ion binding]; other site 698936002785 nucleotide binding site [chemical binding]; other site 698936002786 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698936002787 domain I; other site 698936002788 DNA binding groove [nucleotide binding] 698936002789 phosphate binding site [ion binding]; other site 698936002790 domain II; other site 698936002791 domain III; other site 698936002792 nucleotide binding site [chemical binding]; other site 698936002793 catalytic site [active] 698936002794 domain IV; other site 698936002795 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 698936002796 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698936002797 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698936002798 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698936002799 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 698936002800 DNA protecting protein DprA; Region: dprA; TIGR00732 698936002801 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 698936002802 dihydroorotase; Validated; Region: PRK09059 698936002803 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698936002804 active site 698936002805 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698936002806 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698936002807 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698936002808 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698936002809 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698936002810 active site 698936002811 Predicted permeases [General function prediction only]; Region: COG0679 698936002812 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698936002813 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 698936002814 metal-dependent hydrolase; Provisional; Region: PRK00685 698936002815 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698936002816 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698936002817 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698936002818 hypothetical protein; Provisional; Region: PRK13687 698936002819 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698936002820 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698936002821 GatB domain; Region: GatB_Yqey; smart00845 698936002822 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 698936002823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936002824 Coenzyme A binding pocket [chemical binding]; other site 698936002825 NADH dehydrogenase; Validated; Region: PRK08183 698936002826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 698936002827 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 698936002828 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 698936002829 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698936002830 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698936002831 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698936002832 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 698936002833 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698936002834 carboxyltransferase (CT) interaction site; other site 698936002835 biotinylation site [posttranslational modification]; other site 698936002836 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698936002837 Dehydroquinase class II; Region: DHquinase_II; pfam01220 698936002838 trimer interface [polypeptide binding]; other site 698936002839 active site 698936002840 dimer interface [polypeptide binding]; other site 698936002841 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698936002842 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 698936002843 catalytic residues [active] 698936002844 aspartate aminotransferase; Provisional; Region: PRK05764 698936002845 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936002846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936002847 homodimer interface [polypeptide binding]; other site 698936002848 catalytic residue [active] 698936002849 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 698936002850 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 698936002851 putative active site [active] 698936002852 putative NTP binding site [chemical binding]; other site 698936002853 putative nucleic acid binding site [nucleotide binding]; other site 698936002854 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 698936002855 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698936002856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698936002857 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698936002858 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698936002859 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 698936002860 AMIN domain; Region: AMIN; pfam11741 698936002861 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698936002862 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698936002863 active site 698936002864 metal binding site [ion binding]; metal-binding site 698936002865 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 698936002866 Transglycosylase; Region: Transgly; pfam00912 698936002867 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698936002868 peptide chain release factor 2; Provisional; Region: PRK07342 698936002869 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698936002870 RF-1 domain; Region: RF-1; pfam00472 698936002871 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698936002872 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 698936002873 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 698936002874 dimer interface [polypeptide binding]; other site 698936002875 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936002876 ligand binding site [chemical binding]; other site 698936002877 LysR family transcriptional regulator; Provisional; Region: PRK14997 698936002878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936002879 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 698936002880 putative effector binding pocket; other site 698936002881 putative dimerization interface [polypeptide binding]; other site 698936002882 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 698936002883 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698936002884 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698936002885 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 698936002886 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698936002887 elongation factor Tu; Reviewed; Region: PRK00049 698936002888 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698936002889 G1 box; other site 698936002890 GEF interaction site [polypeptide binding]; other site 698936002891 GTP/Mg2+ binding site [chemical binding]; other site 698936002892 Switch I region; other site 698936002893 G2 box; other site 698936002894 G3 box; other site 698936002895 Switch II region; other site 698936002896 G4 box; other site 698936002897 G5 box; other site 698936002898 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698936002899 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698936002900 Antibiotic Binding Site [chemical binding]; other site 698936002901 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936002902 extended (e) SDRs; Region: SDR_e; cd08946 698936002903 NAD(P) binding site [chemical binding]; other site 698936002904 active site 698936002905 substrate binding site [chemical binding]; other site 698936002906 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 698936002907 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698936002908 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698936002909 putative homodimer interface [polypeptide binding]; other site 698936002910 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698936002911 heterodimer interface [polypeptide binding]; other site 698936002912 homodimer interface [polypeptide binding]; other site 698936002913 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698936002914 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698936002915 23S rRNA interface [nucleotide binding]; other site 698936002916 L7/L12 interface [polypeptide binding]; other site 698936002917 putative thiostrepton binding site; other site 698936002918 L25 interface [polypeptide binding]; other site 698936002919 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698936002920 mRNA/rRNA interface [nucleotide binding]; other site 698936002921 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698936002922 23S rRNA interface [nucleotide binding]; other site 698936002923 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698936002924 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 698936002925 core dimer interface [polypeptide binding]; other site 698936002926 peripheral dimer interface [polypeptide binding]; other site 698936002927 L10 interface [polypeptide binding]; other site 698936002928 L11 interface [polypeptide binding]; other site 698936002929 putative EF-Tu interaction site [polypeptide binding]; other site 698936002930 putative EF-G interaction site [polypeptide binding]; other site 698936002931 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698936002932 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698936002933 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698936002934 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698936002935 RPB11 interaction site [polypeptide binding]; other site 698936002936 RPB12 interaction site [polypeptide binding]; other site 698936002937 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698936002938 RPB1 interaction site [polypeptide binding]; other site 698936002939 RPB11 interaction site [polypeptide binding]; other site 698936002940 RPB10 interaction site [polypeptide binding]; other site 698936002941 RPB3 interaction site [polypeptide binding]; other site 698936002942 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698936002943 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 698936002944 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698936002945 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698936002946 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698936002947 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 698936002948 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 698936002949 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 698936002950 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 698936002951 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698936002952 DNA binding site [nucleotide binding] 698936002953 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698936002954 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698936002955 S17 interaction site [polypeptide binding]; other site 698936002956 S8 interaction site; other site 698936002957 16S rRNA interaction site [nucleotide binding]; other site 698936002958 streptomycin interaction site [chemical binding]; other site 698936002959 23S rRNA interaction site [nucleotide binding]; other site 698936002960 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698936002961 30S ribosomal protein S7; Validated; Region: PRK05302 698936002962 elongation factor G; Reviewed; Region: PRK00007 698936002963 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698936002964 G1 box; other site 698936002965 putative GEF interaction site [polypeptide binding]; other site 698936002966 GTP/Mg2+ binding site [chemical binding]; other site 698936002967 Switch I region; other site 698936002968 G2 box; other site 698936002969 G3 box; other site 698936002970 Switch II region; other site 698936002971 G4 box; other site 698936002972 G5 box; other site 698936002973 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698936002974 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698936002975 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698936002976 elongation factor Tu; Reviewed; Region: PRK00049 698936002977 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698936002978 G1 box; other site 698936002979 GEF interaction site [polypeptide binding]; other site 698936002980 GTP/Mg2+ binding site [chemical binding]; other site 698936002981 Switch I region; other site 698936002982 G2 box; other site 698936002983 G3 box; other site 698936002984 Switch II region; other site 698936002985 G4 box; other site 698936002986 G5 box; other site 698936002987 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698936002988 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698936002989 Antibiotic Binding Site [chemical binding]; other site 698936002990 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698936002991 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698936002992 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698936002993 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698936002994 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698936002995 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698936002996 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698936002997 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698936002998 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698936002999 putative translocon binding site; other site 698936003000 protein-rRNA interface [nucleotide binding]; other site 698936003001 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698936003002 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698936003003 G-X-X-G motif; other site 698936003004 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698936003005 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698936003006 23S rRNA interface [nucleotide binding]; other site 698936003007 5S rRNA interface [nucleotide binding]; other site 698936003008 putative antibiotic binding site [chemical binding]; other site 698936003009 L25 interface [polypeptide binding]; other site 698936003010 L27 interface [polypeptide binding]; other site 698936003011 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698936003012 23S rRNA interface [nucleotide binding]; other site 698936003013 putative translocon interaction site; other site 698936003014 signal recognition particle (SRP54) interaction site; other site 698936003015 L23 interface [polypeptide binding]; other site 698936003016 trigger factor interaction site; other site 698936003017 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698936003018 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698936003019 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698936003020 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698936003021 RNA binding site [nucleotide binding]; other site 698936003022 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698936003023 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698936003024 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698936003025 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 698936003026 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698936003027 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698936003028 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698936003029 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698936003030 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698936003031 23S rRNA interface [nucleotide binding]; other site 698936003032 L21e interface [polypeptide binding]; other site 698936003033 5S rRNA interface [nucleotide binding]; other site 698936003034 L27 interface [polypeptide binding]; other site 698936003035 L5 interface [polypeptide binding]; other site 698936003036 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698936003037 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698936003038 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698936003039 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698936003040 23S rRNA binding site [nucleotide binding]; other site 698936003041 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698936003042 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698936003043 SecY translocase; Region: SecY; pfam00344 698936003044 adenylate kinase; Reviewed; Region: adk; PRK00279 698936003045 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698936003046 AMP-binding site [chemical binding]; other site 698936003047 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698936003048 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698936003049 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698936003050 30S ribosomal protein S11; Validated; Region: PRK05309 698936003051 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698936003052 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698936003053 alphaNTD homodimer interface [polypeptide binding]; other site 698936003054 alphaNTD - beta interaction site [polypeptide binding]; other site 698936003055 alphaNTD - beta' interaction site [polypeptide binding]; other site 698936003056 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698936003057 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698936003058 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 698936003059 TMAO/DMSO reductase; Reviewed; Region: PRK05363 698936003060 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 698936003061 Moco binding site; other site 698936003062 metal coordination site [ion binding]; other site 698936003063 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 698936003064 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698936003065 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698936003066 protein binding site [polypeptide binding]; other site 698936003067 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698936003068 protein binding site [polypeptide binding]; other site 698936003069 recombination factor protein RarA; Reviewed; Region: PRK13342 698936003070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936003071 Walker A motif; other site 698936003072 ATP binding site [chemical binding]; other site 698936003073 Walker B motif; other site 698936003074 arginine finger; other site 698936003075 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698936003076 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 698936003077 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 698936003078 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698936003079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936003080 motif II; other site 698936003081 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698936003082 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 698936003083 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698936003084 active site 698936003085 camphor resistance protein CrcB; Provisional; Region: PRK14195 698936003086 S-formylglutathione hydrolase; Region: PLN02442 698936003087 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 698936003088 Predicted membrane protein [Function unknown]; Region: COG4291 698936003089 hypothetical protein; Validated; Region: PRK00124 698936003090 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 698936003091 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 698936003092 substrate binding site [chemical binding]; other site 698936003093 catalytic Zn binding site [ion binding]; other site 698936003094 NAD binding site [chemical binding]; other site 698936003095 structural Zn binding site [ion binding]; other site 698936003096 dimer interface [polypeptide binding]; other site 698936003097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936003098 non-specific DNA binding site [nucleotide binding]; other site 698936003099 salt bridge; other site 698936003100 sequence-specific DNA binding site [nucleotide binding]; other site 698936003101 lipoate-protein ligase B; Provisional; Region: PRK14341 698936003102 PrkA family serine protein kinase; Provisional; Region: PRK15455 698936003103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 698936003104 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 698936003105 Uncharacterized conserved protein [Function unknown]; Region: COG2718 698936003106 SpoVR family protein; Provisional; Region: PRK11767 698936003107 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 698936003108 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698936003109 active site 698936003110 catalytic residues [active] 698936003111 metal binding site [ion binding]; metal-binding site 698936003112 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698936003113 MgtE intracellular N domain; Region: MgtE_N; smart00924 698936003114 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698936003115 Divalent cation transporter; Region: MgtE; cl00786 698936003116 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 698936003117 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 698936003118 DNA binding residues [nucleotide binding] 698936003119 putative dimer interface [polypeptide binding]; other site 698936003120 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 698936003121 Predicted membrane protein [Function unknown]; Region: COG3503 698936003122 Predicted membrane protein [Function unknown]; Region: COG3821 698936003123 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698936003124 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698936003125 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698936003126 Uncharacterized conserved protein [Function unknown]; Region: COG5458 698936003127 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698936003128 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698936003129 Sporulation related domain; Region: SPOR; pfam05036 698936003130 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 698936003131 PilZ domain; Region: PilZ; pfam07238 698936003132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 698936003133 PAS domain; Region: PAS_5; pfam07310 698936003134 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 698936003135 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 698936003136 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 698936003137 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 698936003138 nucleophile elbow; other site 698936003139 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 698936003140 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 698936003141 GTP cyclohydrolase I; Provisional; Region: PLN03044 698936003142 active site 698936003143 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698936003144 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698936003145 trimerization site [polypeptide binding]; other site 698936003146 active site 698936003147 hypothetical protein; Validated; Region: PRK00041 698936003148 Uncharacterized conserved protein [Function unknown]; Region: COG5502 698936003149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 698936003150 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 698936003151 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 698936003152 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698936003153 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698936003154 active site 698936003155 dimer interface [polypeptide binding]; other site 698936003156 motif 1; other site 698936003157 motif 2; other site 698936003158 motif 3; other site 698936003159 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698936003160 anticodon binding site; other site 698936003161 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 698936003162 putative FMN binding site [chemical binding]; other site 698936003163 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 698936003164 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 698936003165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 698936003166 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 698936003167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936003168 Coenzyme A binding pocket [chemical binding]; other site 698936003169 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 698936003170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936003171 Mg2+ binding site [ion binding]; other site 698936003172 G-X-G motif; other site 698936003173 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698936003174 anchoring element; other site 698936003175 dimer interface [polypeptide binding]; other site 698936003176 ATP binding site [chemical binding]; other site 698936003177 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 698936003178 active site 698936003179 metal binding site [ion binding]; metal-binding site 698936003180 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698936003181 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698936003182 FAD binding domain; Region: FAD_binding_4; pfam01565 698936003183 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698936003184 Uncharacterized conserved protein [Function unknown]; Region: COG2353 698936003185 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 698936003186 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698936003187 triosephosphate isomerase; Provisional; Region: PRK14565 698936003188 substrate binding site [chemical binding]; other site 698936003189 dimer interface [polypeptide binding]; other site 698936003190 catalytic triad [active] 698936003191 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 698936003192 CTP synthetase; Validated; Region: pyrG; PRK05380 698936003193 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 698936003194 Catalytic site [active] 698936003195 active site 698936003196 UTP binding site [chemical binding]; other site 698936003197 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 698936003198 active site 698936003199 putative oxyanion hole; other site 698936003200 catalytic triad [active] 698936003201 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 698936003202 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 698936003203 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 698936003204 enolase; Provisional; Region: eno; PRK00077 698936003205 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698936003206 dimer interface [polypeptide binding]; other site 698936003207 metal binding site [ion binding]; metal-binding site 698936003208 substrate binding pocket [chemical binding]; other site 698936003209 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 698936003210 Septum formation initiator; Region: DivIC; pfam04977 698936003211 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 698936003212 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 698936003213 tetramer interface [polypeptide binding]; other site 698936003214 TPP-binding site [chemical binding]; other site 698936003215 heterodimer interface [polypeptide binding]; other site 698936003216 phosphorylation loop region [posttranslational modification] 698936003217 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 698936003218 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698936003219 E3 interaction surface; other site 698936003220 lipoyl attachment site [posttranslational modification]; other site 698936003221 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 698936003222 alpha subunit interface [polypeptide binding]; other site 698936003223 TPP binding site [chemical binding]; other site 698936003224 heterodimer interface [polypeptide binding]; other site 698936003225 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698936003226 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698936003227 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 698936003228 E3 interaction surface; other site 698936003229 lipoyl attachment site [posttranslational modification]; other site 698936003230 e3 binding domain; Region: E3_binding; pfam02817 698936003231 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698936003232 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 698936003233 active site 698936003234 catalytic triad [active] 698936003235 oxyanion hole [active] 698936003236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936003237 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698936003238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698936003239 Coenzyme A binding pocket [chemical binding]; other site 698936003240 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 698936003241 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698936003242 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936003243 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698936003244 Predicted membrane protein [Function unknown]; Region: COG2261 698936003245 lipoyl synthase; Provisional; Region: PRK05481 698936003246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698936003247 FeS/SAM binding site; other site 698936003248 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 698936003249 putative coenzyme Q binding site [chemical binding]; other site 698936003250 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 698936003251 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 698936003252 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 698936003253 substrate binding site; other site 698936003254 dimer interface; other site 698936003255 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 698936003256 homotrimer interaction site [polypeptide binding]; other site 698936003257 zinc binding site [ion binding]; other site 698936003258 CDP-binding sites; other site 698936003259 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698936003260 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 698936003261 FMN binding site [chemical binding]; other site 698936003262 active site 698936003263 catalytic residues [active] 698936003264 substrate binding site [chemical binding]; other site 698936003265 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 698936003266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936003267 dimer interface [polypeptide binding]; other site 698936003268 phosphorylation site [posttranslational modification] 698936003269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936003270 ATP binding site [chemical binding]; other site 698936003271 Mg2+ binding site [ion binding]; other site 698936003272 G-X-G motif; other site 698936003273 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 698936003274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936003275 active site 698936003276 phosphorylation site [posttranslational modification] 698936003277 intermolecular recognition site; other site 698936003278 dimerization interface [polypeptide binding]; other site 698936003279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936003280 Walker A motif; other site 698936003281 ATP binding site [chemical binding]; other site 698936003282 Walker B motif; other site 698936003283 arginine finger; other site 698936003284 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 698936003285 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 698936003286 HAMP domain; Region: HAMP; pfam00672 698936003287 dimerization interface [polypeptide binding]; other site 698936003288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936003289 dimer interface [polypeptide binding]; other site 698936003290 phosphorylation site [posttranslational modification] 698936003291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936003292 ATP binding site [chemical binding]; other site 698936003293 Mg2+ binding site [ion binding]; other site 698936003294 G-X-G motif; other site 698936003295 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 698936003296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936003297 active site 698936003298 phosphorylation site [posttranslational modification] 698936003299 intermolecular recognition site; other site 698936003300 dimerization interface [polypeptide binding]; other site 698936003301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936003302 Walker A motif; other site 698936003303 ATP binding site [chemical binding]; other site 698936003304 Walker B motif; other site 698936003305 arginine finger; other site 698936003306 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 698936003307 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 698936003308 TrkA-N domain; Region: TrkA_N; pfam02254 698936003309 TrkA-C domain; Region: TrkA_C; pfam02080 698936003310 TrkA-N domain; Region: TrkA_N; pfam02254 698936003311 TrkA-C domain; Region: TrkA_C; pfam02080 698936003312 bacterial Hfq-like; Region: Hfq; cd01716 698936003313 hexamer interface [polypeptide binding]; other site 698936003314 Sm1 motif; other site 698936003315 RNA binding site [nucleotide binding]; other site 698936003316 Sm2 motif; other site 698936003317 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 698936003318 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698936003319 HflX GTPase family; Region: HflX; cd01878 698936003320 G1 box; other site 698936003321 GTP/Mg2+ binding site [chemical binding]; other site 698936003322 Switch I region; other site 698936003323 G2 box; other site 698936003324 G3 box; other site 698936003325 Switch II region; other site 698936003326 G4 box; other site 698936003327 G5 box; other site 698936003328 Helix-turn-helix domain; Region: HTH_28; pfam13518 698936003329 Winged helix-turn helix; Region: HTH_29; pfam13551 698936003330 Homeodomain-like domain; Region: HTH_32; pfam13565 698936003331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698936003332 Integrase core domain; Region: rve; pfam00665 698936003333 Integrase core domain; Region: rve_3; pfam13683 698936003334 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 698936003335 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 698936003336 homodimer interface [polypeptide binding]; other site 698936003337 metal binding site [ion binding]; metal-binding site 698936003338 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 698936003339 homodimer interface [polypeptide binding]; other site 698936003340 active site 698936003341 putative chemical substrate binding site [chemical binding]; other site 698936003342 metal binding site [ion binding]; metal-binding site 698936003343 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698936003344 nucleoside/Zn binding site; other site 698936003345 dimer interface [polypeptide binding]; other site 698936003346 catalytic motif [active] 698936003347 siroheme synthase; Provisional; Region: cysG; PRK10637 698936003348 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 698936003349 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 698936003350 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698936003351 active site 698936003352 SAM binding site [chemical binding]; other site 698936003353 homodimer interface [polypeptide binding]; other site 698936003354 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 698936003355 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 698936003356 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698936003357 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698936003358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 698936003359 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698936003360 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 698936003361 FAD binding pocket [chemical binding]; other site 698936003362 FAD binding motif [chemical binding]; other site 698936003363 phosphate binding motif [ion binding]; other site 698936003364 beta-alpha-beta structure motif; other site 698936003365 NAD binding pocket [chemical binding]; other site 698936003366 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 698936003367 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698936003368 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698936003369 Walker A/P-loop; other site 698936003370 ATP binding site [chemical binding]; other site 698936003371 Q-loop/lid; other site 698936003372 ABC transporter signature motif; other site 698936003373 Walker B; other site 698936003374 D-loop; other site 698936003375 H-loop/switch region; other site 698936003376 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936003377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936003378 dimer interface [polypeptide binding]; other site 698936003379 conserved gate region; other site 698936003380 putative PBP binding loops; other site 698936003381 ABC-ATPase subunit interface; other site 698936003382 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 698936003383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698936003384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936003385 dimer interface [polypeptide binding]; other site 698936003386 conserved gate region; other site 698936003387 putative PBP binding loops; other site 698936003388 ABC-ATPase subunit interface; other site 698936003389 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 698936003390 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936003391 substrate binding pocket [chemical binding]; other site 698936003392 membrane-bound complex binding site; other site 698936003393 hinge residues; other site 698936003394 cystathionine beta-lyase; Provisional; Region: PRK05967 698936003395 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698936003396 homodimer interface [polypeptide binding]; other site 698936003397 substrate-cofactor binding pocket; other site 698936003398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936003399 catalytic residue [active] 698936003400 salicylate hydroxylase; Provisional; Region: PRK08163 698936003401 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698936003402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 698936003403 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698936003404 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936003405 serine acetyltransferase; Provisional; Region: cysE; PRK11132 698936003406 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 698936003407 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698936003408 trimer interface [polypeptide binding]; other site 698936003409 active site 698936003410 substrate binding site [chemical binding]; other site 698936003411 CoA binding site [chemical binding]; other site 698936003412 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 698936003413 Phasin protein; Region: Phasin_2; pfam09361 698936003414 Uncharacterized conserved protein [Function unknown]; Region: COG2127 698936003415 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 698936003416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936003417 Walker A motif; other site 698936003418 ATP binding site [chemical binding]; other site 698936003419 Walker B motif; other site 698936003420 arginine finger; other site 698936003421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936003422 Walker A motif; other site 698936003423 ATP binding site [chemical binding]; other site 698936003424 Walker B motif; other site 698936003425 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698936003426 AzlC protein; Region: AzlC; pfam03591 698936003427 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 698936003428 HIT family signature motif; other site 698936003429 catalytic residue [active] 698936003430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 698936003431 Protein of unknown function, DUF482; Region: DUF482; pfam04339 698936003432 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 698936003433 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698936003434 putative active site [active] 698936003435 catalytic site [active] 698936003436 putative metal binding site [ion binding]; other site 698936003437 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698936003438 homotrimer interaction site [polypeptide binding]; other site 698936003439 putative active site [active] 698936003440 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 698936003441 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698936003442 rRNA interaction site [nucleotide binding]; other site 698936003443 S8 interaction site; other site 698936003444 putative laminin-1 binding site; other site 698936003445 elongation factor Ts; Provisional; Region: tsf; PRK09377 698936003446 UBA/TS-N domain; Region: UBA; pfam00627 698936003447 Elongation factor TS; Region: EF_TS; pfam00889 698936003448 Elongation factor TS; Region: EF_TS; pfam00889 698936003449 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698936003450 putative nucleotide binding site [chemical binding]; other site 698936003451 uridine monophosphate binding site [chemical binding]; other site 698936003452 homohexameric interface [polypeptide binding]; other site 698936003453 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698936003454 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698936003455 hinge region; other site 698936003456 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 698936003457 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 698936003458 catalytic residue [active] 698936003459 putative FPP diphosphate binding site; other site 698936003460 putative FPP binding hydrophobic cleft; other site 698936003461 dimer interface [polypeptide binding]; other site 698936003462 putative IPP diphosphate binding site; other site 698936003463 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698936003464 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698936003465 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 698936003466 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698936003467 active site 698936003468 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698936003469 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698936003470 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698936003471 putative substrate binding region [chemical binding]; other site 698936003472 putative substrate binding region [chemical binding]; other site 698936003473 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 698936003474 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 698936003475 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 698936003476 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 698936003477 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 698936003478 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 698936003479 Surface antigen; Region: Bac_surface_Ag; pfam01103 698936003480 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 698936003481 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 698936003482 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 698936003483 trimer interface [polypeptide binding]; other site 698936003484 active site 698936003485 UDP-GlcNAc binding site [chemical binding]; other site 698936003486 lipid binding site [chemical binding]; lipid-binding site 698936003487 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 698936003488 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 698936003489 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 698936003490 active site 698936003491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 698936003492 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 698936003493 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 698936003494 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 698936003495 GIY-YIG motif/motif A; other site 698936003496 putative active site [active] 698936003497 putative metal binding site [ion binding]; other site 698936003498 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698936003499 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 698936003500 dimer interface [polypeptide binding]; other site 698936003501 active site 698936003502 citrylCoA binding site [chemical binding]; other site 698936003503 NADH binding [chemical binding]; other site 698936003504 cationic pore residues; other site 698936003505 oxalacetate/citrate binding site [chemical binding]; other site 698936003506 coenzyme A binding site [chemical binding]; other site 698936003507 catalytic triad [active] 698936003508 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 698936003509 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 698936003510 Competence protein; Region: Competence; pfam03772 698936003511 tonB-system energizer ExbB; Region: exbB; TIGR02797 698936003512 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 698936003513 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 698936003514 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 698936003515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698936003516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936003517 S-adenosylmethionine binding site [chemical binding]; other site 698936003518 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 698936003519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 698936003520 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698936003521 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698936003522 HIGH motif; other site 698936003523 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698936003524 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698936003525 active site 698936003526 KMSKS motif; other site 698936003527 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698936003528 tRNA binding surface [nucleotide binding]; other site 698936003529 anticodon binding site; other site 698936003530 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698936003531 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 698936003532 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 698936003533 Sel1-like repeats; Region: SEL1; smart00671 698936003534 Sel1-like repeats; Region: SEL1; smart00671 698936003535 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 698936003536 putative catalytic site [active] 698936003537 putative phosphate binding site [ion binding]; other site 698936003538 active site 698936003539 metal binding site A [ion binding]; metal-binding site 698936003540 DNA binding site [nucleotide binding] 698936003541 putative AP binding site [nucleotide binding]; other site 698936003542 putative metal binding site B [ion binding]; other site 698936003543 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698936003544 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 698936003545 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 698936003546 putative active site [active] 698936003547 catalytic site [active] 698936003548 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 698936003549 putative active site [active] 698936003550 catalytic site [active] 698936003551 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 698936003552 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 698936003553 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698936003554 Zn2+ binding site [ion binding]; other site 698936003555 Mg2+ binding site [ion binding]; other site 698936003556 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 698936003557 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 698936003558 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 698936003559 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698936003560 active site 698936003561 HIGH motif; other site 698936003562 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698936003563 KMSK motif region; other site 698936003564 tRNA binding surface [nucleotide binding]; other site 698936003565 DALR anticodon binding domain; Region: DALR_1; smart00836 698936003566 anticodon binding site; other site 698936003567 Sporulation related domain; Region: SPOR; pfam05036 698936003568 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698936003569 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698936003570 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 698936003571 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 698936003572 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698936003573 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698936003574 Walker A/P-loop; other site 698936003575 ATP binding site [chemical binding]; other site 698936003576 Q-loop/lid; other site 698936003577 ABC transporter signature motif; other site 698936003578 Walker B; other site 698936003579 D-loop; other site 698936003580 H-loop/switch region; other site 698936003581 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 698936003582 sec-independent translocase; Provisional; Region: PRK00708 698936003583 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 698936003584 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 698936003585 seryl-tRNA synthetase; Provisional; Region: PRK05431 698936003586 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698936003587 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698936003588 dimer interface [polypeptide binding]; other site 698936003589 active site 698936003590 motif 1; other site 698936003591 motif 2; other site 698936003592 motif 3; other site 698936003593 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 698936003594 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 698936003595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936003596 S-adenosylmethionine binding site [chemical binding]; other site 698936003597 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 698936003598 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698936003599 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698936003600 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698936003601 Peptidase family M23; Region: Peptidase_M23; pfam01551 698936003602 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 698936003603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936003604 Walker A motif; other site 698936003605 ATP binding site [chemical binding]; other site 698936003606 Walker B motif; other site 698936003607 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 698936003608 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 698936003609 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 698936003610 Protein export membrane protein; Region: SecD_SecF; cl14618 698936003611 Protein export membrane protein; Region: SecD_SecF; pfam02355 698936003612 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 698936003613 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 698936003614 substrate binding pocket [chemical binding]; other site 698936003615 aspartate-rich region 1; other site 698936003616 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 698936003617 Glucose inhibited division protein A; Region: GIDA; pfam01134 698936003618 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 698936003619 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 698936003620 trigger factor; Provisional; Region: tig; PRK01490 698936003621 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698936003622 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698936003623 glycine dehydrogenase; Provisional; Region: PRK05367 698936003624 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 698936003625 tetramer interface [polypeptide binding]; other site 698936003626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936003627 catalytic residue [active] 698936003628 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 698936003629 tetramer interface [polypeptide binding]; other site 698936003630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936003631 catalytic residue [active] 698936003632 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 698936003633 lipoyl attachment site [posttranslational modification]; other site 698936003634 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 698936003635 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698936003636 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 698936003637 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 698936003638 CRISPR-associated protein, Csx11 family; Region: cas_csx11; TIGR02682 698936003639 GST_N family, Class Phi subfamily; composed of plant-specific class Phi GSTs and related fungal and bacterial proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide...; Region: GST_N_Phi; cd03053 698936003640 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936003641 C-terminal domain interface [polypeptide binding]; other site 698936003642 GSH binding site (G-site) [chemical binding]; other site 698936003643 dimer interface [polypeptide binding]; other site 698936003644 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 698936003645 dimer interface [polypeptide binding]; other site 698936003646 N-terminal domain interface [polypeptide binding]; other site 698936003647 substrate binding pocket (H-site) [chemical binding]; other site 698936003648 TniQ; Region: TniQ; pfam06527 698936003649 AAA ATPase domain; Region: AAA_16; pfam13191 698936003650 AAA domain; Region: AAA_22; pfam13401 698936003651 Integrase core domain; Region: rve; pfam00665 698936003652 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 698936003653 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698936003654 oligomeric interface; other site 698936003655 putative active site [active] 698936003656 homodimer interface [polypeptide binding]; other site 698936003657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936003658 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 698936003659 Walker A motif; other site 698936003660 ATP binding site [chemical binding]; other site 698936003661 Walker B motif; other site 698936003662 arginine finger; other site 698936003663 Peptidase family M41; Region: Peptidase_M41; pfam01434 698936003664 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 698936003665 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698936003666 ATP binding site [chemical binding]; other site 698936003667 putative Mg++ binding site [ion binding]; other site 698936003668 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698936003669 nucleotide binding region [chemical binding]; other site 698936003670 ATP-binding site [chemical binding]; other site 698936003671 Predicted periplasmic protein [Function unknown]; Region: COG3904 698936003672 Bacterial SH3 domain; Region: SH3_4; pfam06347 698936003673 Excalibur calcium-binding domain; Region: Excalibur; smart00894 698936003674 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 698936003675 ligand binding site [chemical binding]; other site 698936003676 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 698936003677 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 698936003678 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 698936003679 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 698936003680 Catalytic site; other site 698936003681 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 698936003682 HNH endonuclease; Region: HNH_2; pfam13391 698936003683 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 698936003684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936003685 S-adenosylmethionine binding site [chemical binding]; other site 698936003686 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 698936003687 ATP-binding site [chemical binding]; other site 698936003688 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 698936003689 putative active site [active] 698936003690 catalytic site [active] 698936003691 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 698936003692 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 698936003693 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 698936003694 ATP binding site [chemical binding]; other site 698936003695 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 698936003696 metal binding triad [ion binding]; metal-binding site 698936003697 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 698936003698 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 698936003699 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698936003700 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 698936003701 active site 698936003702 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698936003703 TSCPD domain; Region: TSCPD; pfam12637 698936003704 Uncharacterized conserved protein [Function unknown]; Region: COG1801 698936003705 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698936003706 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698936003707 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698936003708 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698936003709 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698936003710 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698936003711 dimer interface [polypeptide binding]; other site 698936003712 ssDNA binding site [nucleotide binding]; other site 698936003713 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698936003714 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 698936003715 DNA gyrase subunit A; Validated; Region: PRK05560 698936003716 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698936003717 CAP-like domain; other site 698936003718 active site 698936003719 primary dimer interface [polypeptide binding]; other site 698936003720 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698936003721 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698936003722 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698936003723 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698936003724 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698936003725 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 698936003726 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698936003727 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698936003728 catalytic residue [active] 698936003729 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698936003730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936003731 Coenzyme A binding pocket [chemical binding]; other site 698936003732 Streptomycin 6-kinase [Defense mechanisms]; Region: StrB; COG3570 698936003733 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698936003734 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 698936003735 FMN binding site [chemical binding]; other site 698936003736 active site 698936003737 substrate binding site [chemical binding]; other site 698936003738 catalytic residue [active] 698936003739 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936003740 dimerization interface [polypeptide binding]; other site 698936003741 putative DNA binding site [nucleotide binding]; other site 698936003742 putative Zn2+ binding site [ion binding]; other site 698936003743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936003744 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936003745 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698936003746 putative effector binding pocket; other site 698936003747 dimerization interface [polypeptide binding]; other site 698936003748 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698936003749 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698936003750 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936003751 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936003752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936003753 putative DNA binding site [nucleotide binding]; other site 698936003754 putative Zn2+ binding site [ion binding]; other site 698936003755 AsnC family; Region: AsnC_trans_reg; pfam01037 698936003756 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 698936003757 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698936003758 putative metal binding site; other site 698936003759 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936003760 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 698936003761 putative ADP-binding pocket [chemical binding]; other site 698936003762 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936003763 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 698936003764 putative ADP-binding pocket [chemical binding]; other site 698936003765 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698936003766 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936003767 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698936003768 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698936003769 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698936003770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936003771 putative substrate translocation pore; other site 698936003772 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698936003773 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698936003774 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698936003775 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698936003776 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698936003777 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698936003778 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698936003779 IMP binding site; other site 698936003780 dimer interface [polypeptide binding]; other site 698936003781 partial ornithine binding site; other site 698936003782 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698936003783 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 698936003784 putative NAD(P) binding site [chemical binding]; other site 698936003785 catalytic Zn binding site [ion binding]; other site 698936003786 Predicted metalloprotease [General function prediction only]; Region: COG2321 698936003787 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 698936003788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936003789 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936003790 putative substrate translocation pore; other site 698936003791 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 698936003792 putative efflux protein, MATE family; Region: matE; TIGR00797 698936003793 cation binding site [ion binding]; other site 698936003794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 698936003795 Helix-turn-helix domain; Region: HTH_28; pfam13518 698936003796 Homeodomain-like domain; Region: HTH_32; pfam13565 698936003797 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698936003798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698936003799 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698936003800 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698936003801 active site 698936003802 (T/H)XGH motif; other site 698936003803 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698936003804 active site 698936003805 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698936003806 active site 698936003807 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 698936003808 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 698936003809 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 698936003810 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698936003811 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698936003812 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936003813 substrate binding pocket [chemical binding]; other site 698936003814 membrane-bound complex binding site; other site 698936003815 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698936003816 classical (c) SDRs; Region: SDR_c; cd05233 698936003817 NAD(P) binding site [chemical binding]; other site 698936003818 active site 698936003819 SEC-C motif; Region: SEC-C; pfam02810 698936003820 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698936003821 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 698936003822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698936003823 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698936003824 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936003825 classical (c) SDRs; Region: SDR_c; cd05233 698936003826 NAD(P) binding site [chemical binding]; other site 698936003827 active site 698936003828 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936003829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936003830 putative substrate translocation pore; other site 698936003831 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 698936003832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936003833 DNA binding site [nucleotide binding] 698936003834 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936003835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936003836 TPR motif; other site 698936003837 binding surface 698936003838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936003839 TPR motif; other site 698936003840 binding surface 698936003841 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698936003842 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698936003843 Winged helix-turn helix; Region: HTH_29; pfam13551 698936003844 DNA-binding interface [nucleotide binding]; DNA binding site 698936003845 Homeodomain-like domain; Region: HTH_32; pfam13565 698936003846 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 698936003847 putative hydrolase; Provisional; Region: PRK02113 698936003848 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 698936003849 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698936003850 active site 698936003851 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 698936003852 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698936003853 active site 698936003854 HIGH motif; other site 698936003855 KMSKS motif; other site 698936003856 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698936003857 tRNA binding surface [nucleotide binding]; other site 698936003858 anticodon binding site; other site 698936003859 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538 698936003860 metal binding site [ion binding]; metal-binding site 698936003861 DNA polymerase III subunit delta'; Validated; Region: PRK09112 698936003862 AAA ATPase domain; Region: AAA_16; pfam13191 698936003863 DNA polymerase III subunit delta'; Validated; Region: PRK08485 698936003864 Peptidase family M23; Region: Peptidase_M23; pfam01551 698936003865 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 698936003866 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698936003867 TMP-binding site; other site 698936003868 ATP-binding site [chemical binding]; other site 698936003869 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 698936003870 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698936003871 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 698936003872 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 698936003873 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 698936003874 Uncharacterized conserved protein [Function unknown]; Region: COG5361 698936003875 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 698936003876 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 698936003877 Uncharacterized conserved protein [Function unknown]; Region: COG5361 698936003878 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 698936003879 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 698936003880 LexA repressor; Validated; Region: PRK00215 698936003881 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 698936003882 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698936003883 Catalytic site [active] 698936003884 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698936003885 active site 698936003886 DNA binding site [nucleotide binding] 698936003887 Int/Topo IB signature motif; other site 698936003888 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 698936003889 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 698936003890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698936003891 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 698936003892 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698936003893 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 698936003894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698936003895 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 698936003896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698936003897 Transposase; Region: HTH_Tnp_1; pfam01527 698936003898 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698936003899 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 698936003900 Protein export membrane protein; Region: SecD_SecF; cl14618 698936003901 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698936003902 catalytic residue [active] 698936003903 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 698936003904 Protein of unknown function (DUF2806); Region: DUF2806; cl12560 698936003905 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 698936003906 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 698936003907 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 698936003908 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 698936003909 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 698936003910 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 698936003911 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 698936003912 tandem repeat interface [polypeptide binding]; other site 698936003913 oligomer interface [polypeptide binding]; other site 698936003914 active site residues [active] 698936003915 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 698936003916 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 698936003917 gpW; Region: gpW; pfam02831 698936003918 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 698936003919 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698936003920 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 698936003921 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698936003922 heterodimer interface [polypeptide binding]; other site 698936003923 homodimer interface [polypeptide binding]; other site 698936003924 Helix-turn-helix domain; Region: HTH_36; pfam13730 698936003925 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 698936003926 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 698936003927 substrate interaction site [chemical binding]; other site 698936003928 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 698936003929 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 698936003930 MT-A70; Region: MT-A70; cl01947 698936003931 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698936003932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936003933 non-specific DNA binding site [nucleotide binding]; other site 698936003934 salt bridge; other site 698936003935 sequence-specific DNA binding site [nucleotide binding]; other site 698936003936 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698936003937 Catalytic site [active] 698936003938 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 698936003939 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 698936003940 HNH endonuclease; Region: HNH_3; pfam13392 698936003941 EthD domain; Region: EthD; cl17553 698936003942 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 698936003943 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 698936003944 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 698936003945 putative active site [active] 698936003946 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 698936003947 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 698936003948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936003949 short chain dehydrogenase; Provisional; Region: PRK06101 698936003950 NAD(P) binding site [chemical binding]; other site 698936003951 active site 698936003952 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698936003953 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698936003954 dimer interface [polypeptide binding]; other site 698936003955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936003956 catalytic residue [active] 698936003957 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 698936003958 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698936003959 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698936003960 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698936003961 active site residue [active] 698936003962 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698936003963 active site residue [active] 698936003964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698936003965 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 698936003966 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 698936003967 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 698936003968 hexamer interface [polypeptide binding]; other site 698936003969 ligand binding site [chemical binding]; other site 698936003970 putative active site [active] 698936003971 NAD(P) binding site [chemical binding]; other site 698936003972 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936003973 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936003974 putative DNA binding site [nucleotide binding]; other site 698936003975 putative Zn2+ binding site [ion binding]; other site 698936003976 AsnC family; Region: AsnC_trans_reg; pfam01037 698936003977 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 698936003978 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 698936003979 active site 698936003980 metal binding site [ion binding]; metal-binding site 698936003981 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 698936003982 Uncharacterized conserved protein [Function unknown]; Region: COG5453 698936003983 threonine dehydratase; Validated; Region: PRK08639 698936003984 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698936003985 tetramer interface [polypeptide binding]; other site 698936003986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936003987 catalytic residue [active] 698936003988 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698936003989 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698936003990 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698936003991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 698936003992 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 698936003993 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698936003994 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 698936003995 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 698936003996 putative MPT binding site; other site 698936003997 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698936003998 active site 698936003999 Uncharacterized conserved protein [Function unknown]; Region: COG0062 698936004000 putative carbohydrate kinase; Provisional; Region: PRK10565 698936004001 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698936004002 putative substrate binding site [chemical binding]; other site 698936004003 putative ATP binding site [chemical binding]; other site 698936004004 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698936004005 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698936004006 glutamine synthetase; Provisional; Region: glnA; PRK09469 698936004007 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698936004008 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698936004009 Uncharacterized conserved protein [Function unknown]; Region: COG3785 698936004010 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 698936004011 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 698936004012 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 698936004013 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 698936004014 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 698936004015 catalytic residues [active] 698936004016 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 698936004017 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936004018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936004019 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 698936004020 Sulfatase; Region: Sulfatase; pfam00884 698936004021 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 698936004022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 698936004023 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 698936004024 putative catalytic site [active] 698936004025 putative phosphate binding site [ion binding]; other site 698936004026 active site 698936004027 metal binding site A [ion binding]; metal-binding site 698936004028 DNA binding site [nucleotide binding] 698936004029 putative AP binding site [nucleotide binding]; other site 698936004030 putative metal binding site B [ion binding]; other site 698936004031 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698936004032 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 698936004033 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698936004034 ATP binding site [chemical binding]; other site 698936004035 putative Mg++ binding site [ion binding]; other site 698936004036 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698936004037 nucleotide binding region [chemical binding]; other site 698936004038 ATP-binding site [chemical binding]; other site 698936004039 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 698936004040 Uncharacterized conserved protein [Function unknown]; Region: COG2938 698936004041 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 698936004042 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698936004043 generic binding surface II; other site 698936004044 ssDNA binding site; other site 698936004045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698936004046 ATP binding site [chemical binding]; other site 698936004047 putative Mg++ binding site [ion binding]; other site 698936004048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698936004049 nucleotide binding region [chemical binding]; other site 698936004050 ATP-binding site [chemical binding]; other site 698936004051 Uncharacterized conserved protein [Function unknown]; Region: COG2928 698936004052 putative acetyltransferase; Provisional; Region: PRK03624 698936004053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936004054 Coenzyme A binding pocket [chemical binding]; other site 698936004055 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698936004056 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698936004057 glutaminase active site [active] 698936004058 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698936004059 dimer interface [polypeptide binding]; other site 698936004060 active site 698936004061 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698936004062 dimer interface [polypeptide binding]; other site 698936004063 active site 698936004064 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 698936004065 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698936004066 Substrate binding site; other site 698936004067 Mg++ binding site; other site 698936004068 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698936004069 active site 698936004070 substrate binding site [chemical binding]; other site 698936004071 CoA binding site [chemical binding]; other site 698936004072 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 698936004073 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 698936004074 PhoU domain; Region: PhoU; pfam01895 698936004075 PhoU domain; Region: PhoU; pfam01895 698936004076 SurA N-terminal domain; Region: SurA_N_3; cl07813 698936004077 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 698936004078 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 698936004079 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698936004080 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698936004081 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698936004082 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698936004083 active site 698936004084 ribulose/triose binding site [chemical binding]; other site 698936004085 phosphate binding site [ion binding]; other site 698936004086 substrate (anthranilate) binding pocket [chemical binding]; other site 698936004087 product (indole) binding pocket [chemical binding]; other site 698936004088 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698936004089 trimer interface [polypeptide binding]; other site 698936004090 dimer interface [polypeptide binding]; other site 698936004091 putative active site [active] 698936004092 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698936004093 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698936004094 dimer interface [polypeptide binding]; other site 698936004095 putative functional site; other site 698936004096 putative MPT binding site; other site 698936004097 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698936004098 Domain of unknown function DUF21; Region: DUF21; pfam01595 698936004099 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698936004100 Transporter associated domain; Region: CorC_HlyC; smart01091 698936004101 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936004102 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936004103 DNA-binding site [nucleotide binding]; DNA binding site 698936004104 FCD domain; Region: FCD; pfam07729 698936004105 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 698936004106 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 698936004107 putative ligand binding site [chemical binding]; other site 698936004108 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936004109 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698936004110 TM-ABC transporter signature motif; other site 698936004111 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936004112 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698936004113 TM-ABC transporter signature motif; other site 698936004114 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 698936004115 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936004116 Walker A/P-loop; other site 698936004117 ATP binding site [chemical binding]; other site 698936004118 Q-loop/lid; other site 698936004119 ABC transporter signature motif; other site 698936004120 Walker B; other site 698936004121 D-loop; other site 698936004122 H-loop/switch region; other site 698936004123 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936004124 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 698936004125 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 698936004126 NADP binding site [chemical binding]; other site 698936004127 dimer interface [polypeptide binding]; other site 698936004128 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 698936004129 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 698936004130 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 698936004131 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698936004132 Predicted permeases [General function prediction only]; Region: COG0679 698936004133 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698936004134 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698936004135 peptide chain release factor 1; Provisional; Region: PRK04011 698936004136 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 698936004137 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 698936004138 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 698936004139 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 698936004140 conserved cys residue [active] 698936004141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936004142 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 698936004143 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cl00720 698936004144 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936004145 classical (c) SDRs; Region: SDR_c; cd05233 698936004146 NAD(P) binding site [chemical binding]; other site 698936004147 active site 698936004148 acyl-CoA synthetase; Validated; Region: PRK07470 698936004149 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698936004150 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 698936004151 acyl-activating enzyme (AAE) consensus motif; other site 698936004152 acyl-activating enzyme (AAE) consensus motif; other site 698936004153 putative AMP binding site [chemical binding]; other site 698936004154 putative active site [active] 698936004155 putative CoA binding site [chemical binding]; other site 698936004156 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 698936004157 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 698936004158 active site 698936004159 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698936004160 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 698936004161 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936004162 classical (c) SDRs; Region: SDR_c; cd05233 698936004163 NAD(P) binding site [chemical binding]; other site 698936004164 active site 698936004165 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 698936004166 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 698936004167 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 698936004168 DctM-like transporters; Region: DctM; pfam06808 698936004169 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 698936004170 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 698936004171 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936004172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936004173 NAD(P) binding site [chemical binding]; other site 698936004174 active site 698936004175 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 698936004176 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698936004177 PYR/PP interface [polypeptide binding]; other site 698936004178 dimer interface [polypeptide binding]; other site 698936004179 TPP binding site [chemical binding]; other site 698936004180 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698936004181 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698936004182 TPP-binding site [chemical binding]; other site 698936004183 dimer interface [polypeptide binding]; other site 698936004184 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 698936004185 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 698936004186 DctM-like transporters; Region: DctM; pfam06808 698936004187 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 698936004188 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698936004189 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698936004190 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698936004191 MULE transposase domain; Region: MULE; pfam10551 698936004192 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698936004193 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698936004194 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698936004195 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698936004196 catalytic residue [active] 698936004197 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936004198 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936004199 putative DNA binding site [nucleotide binding]; other site 698936004200 putative Zn2+ binding site [ion binding]; other site 698936004201 AsnC family; Region: AsnC_trans_reg; pfam01037 698936004202 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 698936004203 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 698936004204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 698936004205 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936004206 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936004207 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 698936004208 substrate binding pocket [chemical binding]; other site 698936004209 dimerization interface [polypeptide binding]; other site 698936004210 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 698936004211 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 698936004212 Uncharacterized conserved protein [Function unknown]; Region: COG1430 698936004213 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698936004214 DNA-binding site [nucleotide binding]; DNA binding site 698936004215 RNA-binding motif; other site 698936004216 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698936004217 DNA-binding site [nucleotide binding]; DNA binding site 698936004218 RNA-binding motif; other site 698936004219 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936004220 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 698936004221 dimer interface [polypeptide binding]; other site 698936004222 active site 698936004223 metal binding site [ion binding]; metal-binding site 698936004224 glutathione binding site [chemical binding]; other site 698936004225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 698936004226 Peptidase M15; Region: Peptidase_M15_3; pfam08291 698936004227 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 698936004228 DHH family; Region: DHH; pfam01368 698936004229 DHHA1 domain; Region: DHHA1; pfam02272 698936004230 homoserine dehydrogenase; Provisional; Region: PRK06349 698936004231 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698936004232 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698936004233 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698936004234 aminotransferase; Validated; Region: PRK09148 698936004235 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936004236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936004237 homodimer interface [polypeptide binding]; other site 698936004238 catalytic residue [active] 698936004239 Short C-terminal domain; Region: SHOCT; pfam09851 698936004240 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 698936004241 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 698936004242 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 698936004243 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698936004244 active site 698936004245 hypothetical protein; Reviewed; Region: PRK00024 698936004246 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 698936004247 MPN+ (JAMM) motif; other site 698936004248 Zinc-binding site [ion binding]; other site 698936004249 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 698936004250 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698936004251 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698936004252 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936004253 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698936004254 FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997 698936004255 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 698936004256 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698936004257 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698936004258 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698936004259 catalytic residue [active] 698936004260 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698936004261 FeS assembly protein SufD; Region: sufD; TIGR01981 698936004262 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698936004263 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698936004264 Walker A/P-loop; other site 698936004265 ATP binding site [chemical binding]; other site 698936004266 Q-loop/lid; other site 698936004267 ABC transporter signature motif; other site 698936004268 Walker B; other site 698936004269 D-loop; other site 698936004270 H-loop/switch region; other site 698936004271 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 698936004272 putative ABC transporter; Region: ycf24; CHL00085 698936004273 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698936004274 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698936004275 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698936004276 catalytic residue [active] 698936004277 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 698936004278 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377 698936004279 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698936004280 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698936004281 active site 698936004282 HIGH motif; other site 698936004283 dimer interface [polypeptide binding]; other site 698936004284 KMSKS motif; other site 698936004285 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698936004286 RNA binding surface [nucleotide binding]; other site 698936004287 Protein of unknown function; Region: DUF3971; pfam13116 698936004288 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698936004289 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698936004290 catalytic triad [active] 698936004291 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 698936004292 dinuclear metal binding motif [ion binding]; other site 698936004293 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698936004294 Peptidase family M23; Region: Peptidase_M23; pfam01551 698936004295 helicase 45; Provisional; Region: PTZ00424 698936004296 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698936004297 ATP binding site [chemical binding]; other site 698936004298 Mg++ binding site [ion binding]; other site 698936004299 motif III; other site 698936004300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698936004301 nucleotide binding region [chemical binding]; other site 698936004302 ATP-binding site [chemical binding]; other site 698936004303 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_20; cd04679 698936004304 nudix motif; other site 698936004305 TfoX N-terminal domain; Region: TfoX_N; pfam04993 698936004306 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698936004307 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 698936004308 putative MPT binding site; other site 698936004309 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 698936004310 Ligand binding site; other site 698936004311 metal-binding site 698936004312 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 698936004313 XdhC Rossmann domain; Region: XdhC_C; pfam13478 698936004314 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 698936004315 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 698936004316 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 698936004317 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698936004318 metal ion-dependent adhesion site (MIDAS); other site 698936004319 MoxR-like ATPases [General function prediction only]; Region: COG0714 698936004320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936004321 Walker A motif; other site 698936004322 ATP binding site [chemical binding]; other site 698936004323 Walker B motif; other site 698936004324 arginine finger; other site 698936004325 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 698936004326 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 698936004327 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 698936004328 ligand binding site [chemical binding]; other site 698936004329 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 698936004330 putative active site pocket [active] 698936004331 cleavage site 698936004332 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698936004333 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698936004334 substrate binding site [chemical binding]; other site 698936004335 hexamer interface [polypeptide binding]; other site 698936004336 metal binding site [ion binding]; metal-binding site 698936004337 Predicted secreted protein [Function unknown]; Region: COG5497 698936004338 DZF domain; Region: DZF; cl02675 698936004339 adenylosuccinate lyase; Provisional; Region: PRK07492 698936004340 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 698936004341 tetramer interface [polypeptide binding]; other site 698936004342 active site 698936004343 PilZ domain; Region: PilZ; cl01260 698936004344 Predicted integral membrane protein [Function unknown]; Region: COG5473 698936004345 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 698936004346 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698936004347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936004348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936004349 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 698936004350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936004351 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936004352 dimerization interface [polypeptide binding]; other site 698936004353 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 698936004354 hypothetical protein; Provisional; Region: PRK09262 698936004355 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698936004356 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 698936004357 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 698936004358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 698936004359 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 698936004360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 698936004361 Uncharacterized conserved protein [Function unknown]; Region: COG5467 698936004362 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698936004363 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 698936004364 ATP binding site [chemical binding]; other site 698936004365 active site 698936004366 substrate binding site [chemical binding]; other site 698936004367 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 698936004368 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 698936004369 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698936004370 putative active site [active] 698936004371 catalytic triad [active] 698936004372 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 698936004373 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698936004374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936004375 DNA-binding site [nucleotide binding]; DNA binding site 698936004376 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936004377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936004378 homodimer interface [polypeptide binding]; other site 698936004379 catalytic residue [active] 698936004380 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 698936004381 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 698936004382 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698936004383 dimerization interface [polypeptide binding]; other site 698936004384 ATP binding site [chemical binding]; other site 698936004385 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698936004386 dimerization interface [polypeptide binding]; other site 698936004387 ATP binding site [chemical binding]; other site 698936004388 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 698936004389 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 698936004390 putative GSH binding site [chemical binding]; other site 698936004391 catalytic residues [active] 698936004392 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698936004393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936004394 putative substrate translocation pore; other site 698936004395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936004396 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 698936004397 putative substrate translocation pore; other site 698936004398 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 698936004399 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698936004400 active site 698936004401 putative lithium-binding site [ion binding]; other site 698936004402 substrate binding site [chemical binding]; other site 698936004403 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 698936004404 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 698936004405 Ligand Binding Site [chemical binding]; other site 698936004406 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 698936004407 glutaminase; Provisional; Region: PRK00971 698936004408 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698936004409 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698936004410 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698936004411 RNA binding surface [nucleotide binding]; other site 698936004412 Domain of unknown function DUF87; Region: DUF87; pfam01935 698936004413 HerA helicase [Replication, recombination, and repair]; Region: COG0433 698936004414 glutamate racemase; Provisional; Region: PRK00865 698936004415 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 698936004416 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 698936004417 Predicted membrane protein [Function unknown]; Region: COG1289 698936004418 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698936004419 isocitrate dehydrogenase; Validated; Region: PRK08299 698936004420 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 698936004421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936004422 Protein involved in beta-1,3-glucan synthesis [Carbohydrate transport and metabolism]; Region: SMI1; COG4282 698936004423 Uncharacterized conserved protein [Function unknown]; Region: COG5361 698936004424 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 698936004425 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 698936004426 Uncharacterized conserved protein [Function unknown]; Region: COG5361 698936004427 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 698936004428 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 698936004429 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 698936004430 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 698936004431 Sulfate transporter family; Region: Sulfate_transp; pfam00916 698936004432 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 698936004433 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698936004434 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698936004435 motif 1; other site 698936004436 active site 698936004437 motif 2; other site 698936004438 motif 3; other site 698936004439 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698936004440 recombinase A; Provisional; Region: recA; PRK09354 698936004441 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698936004442 hexamer interface [polypeptide binding]; other site 698936004443 Walker A motif; other site 698936004444 ATP binding site [chemical binding]; other site 698936004445 Walker B motif; other site 698936004446 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698936004447 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 698936004448 substrate binding site [chemical binding]; other site 698936004449 ATP binding site [chemical binding]; other site 698936004450 Uncharacterized enzyme involved in pigment biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IndA; COG2313 698936004451 PAS domain; Region: PAS; smart00091 698936004452 PAS domain; Region: PAS_9; pfam13426 698936004453 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 698936004454 PAS domain; Region: PAS; smart00091 698936004455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936004456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936004457 dimer interface [polypeptide binding]; other site 698936004458 phosphorylation site [posttranslational modification] 698936004459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936004460 ATP binding site [chemical binding]; other site 698936004461 Mg2+ binding site [ion binding]; other site 698936004462 G-X-G motif; other site 698936004463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936004464 Response regulator receiver domain; Region: Response_reg; pfam00072 698936004465 active site 698936004466 phosphorylation site [posttranslational modification] 698936004467 intermolecular recognition site; other site 698936004468 dimerization interface [polypeptide binding]; other site 698936004469 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 698936004470 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698936004471 catalytic core [active] 698936004472 Predicted ATPase [General function prediction only]; Region: COG3106 698936004473 Predicted membrane protein [Function unknown]; Region: COG3768 698936004474 Domain of unknown function (DUF697); Region: DUF697; cl12064 698936004475 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698936004476 catalytic center binding site [active] 698936004477 ATP binding site [chemical binding]; other site 698936004478 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698936004479 homooctamer interface [polypeptide binding]; other site 698936004480 active site 698936004481 dihydropteroate synthase; Region: DHPS; TIGR01496 698936004482 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698936004483 substrate binding pocket [chemical binding]; other site 698936004484 dimer interface [polypeptide binding]; other site 698936004485 inhibitor binding site; inhibition site 698936004486 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661 698936004487 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698936004488 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936004489 catalytic loop [active] 698936004490 iron binding site [ion binding]; other site 698936004491 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 698936004492 cytochrome b; Provisional; Region: CYTB; MTH00191 698936004493 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 698936004494 Qi binding site; other site 698936004495 intrachain domain interface; other site 698936004496 interchain domain interface [polypeptide binding]; other site 698936004497 heme bH binding site [chemical binding]; other site 698936004498 heme bL binding site [chemical binding]; other site 698936004499 Qo binding site; other site 698936004500 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 698936004501 interchain domain interface [polypeptide binding]; other site 698936004502 intrachain domain interface; other site 698936004503 Qi binding site; other site 698936004504 Qo binding site; other site 698936004505 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 698936004506 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 698936004507 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 698936004508 [2Fe-2S] cluster binding site [ion binding]; other site 698936004509 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698936004510 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936004511 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 698936004512 Walker A/P-loop; other site 698936004513 ATP binding site [chemical binding]; other site 698936004514 Q-loop/lid; other site 698936004515 ABC transporter signature motif; other site 698936004516 Walker B; other site 698936004517 D-loop; other site 698936004518 H-loop/switch region; other site 698936004519 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698936004520 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936004521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936004522 Walker A/P-loop; other site 698936004523 ATP binding site [chemical binding]; other site 698936004524 Q-loop/lid; other site 698936004525 ABC transporter signature motif; other site 698936004526 Walker B; other site 698936004527 D-loop; other site 698936004528 H-loop/switch region; other site 698936004529 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698936004530 Predicted flavoprotein [General function prediction only]; Region: COG0431 698936004531 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698936004532 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 698936004533 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 698936004534 DNA binding residues [nucleotide binding] 698936004535 dimer interface [polypeptide binding]; other site 698936004536 [2Fe-2S] cluster binding site [ion binding]; other site 698936004537 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936004538 Coproporphyrinogen III oxidase [Coenzyme metabolism]; Region: HemF; COG0408 698936004539 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 698936004540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3657 698936004541 Predicted transcriptional regulator [Transcription]; Region: COG3636 698936004542 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 698936004543 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 698936004544 mce related protein; Region: MCE; pfam02470 698936004545 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 698936004546 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 698936004547 Walker A/P-loop; other site 698936004548 ATP binding site [chemical binding]; other site 698936004549 Q-loop/lid; other site 698936004550 ABC transporter signature motif; other site 698936004551 Walker B; other site 698936004552 D-loop; other site 698936004553 H-loop/switch region; other site 698936004554 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 698936004555 Permease; Region: Permease; pfam02405 698936004556 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 698936004557 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 698936004558 active site 698936004559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936004560 putative substrate translocation pore; other site 698936004561 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 698936004562 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698936004563 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 698936004564 putative active site [active] 698936004565 putative metal binding site [ion binding]; other site 698936004566 malic enzyme; Reviewed; Region: PRK12862 698936004567 Malic enzyme, N-terminal domain; Region: malic; pfam00390 698936004568 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 698936004569 putative NAD(P) binding site [chemical binding]; other site 698936004570 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 698936004571 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698936004572 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936004573 DNA binding residues [nucleotide binding] 698936004574 dimerization interface [polypeptide binding]; other site 698936004575 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 698936004576 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 698936004577 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 698936004578 putative FMN binding site [chemical binding]; other site 698936004579 short chain dehydrogenase; Provisional; Region: PRK06198 698936004580 classical (c) SDRs; Region: SDR_c; cd05233 698936004581 NAD(P) binding site [chemical binding]; other site 698936004582 active site 698936004583 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 698936004584 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936004585 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936004586 DNA binding site [nucleotide binding] 698936004587 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 698936004588 putative ligand binding site [chemical binding]; other site 698936004589 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 698936004590 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 698936004591 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 698936004592 NAD synthetase; Provisional; Region: PRK13981 698936004593 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 698936004594 multimer interface [polypeptide binding]; other site 698936004595 active site 698936004596 catalytic triad [active] 698936004597 protein interface 1 [polypeptide binding]; other site 698936004598 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698936004599 homodimer interface [polypeptide binding]; other site 698936004600 NAD binding pocket [chemical binding]; other site 698936004601 ATP binding pocket [chemical binding]; other site 698936004602 Mg binding site [ion binding]; other site 698936004603 active-site loop [active] 698936004604 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 698936004605 Sulfatase; Region: Sulfatase; pfam00884 698936004606 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 698936004607 TadE-like protein; Region: TadE; pfam07811 698936004608 Predicted membrane protein [Function unknown]; Region: COG4655 698936004609 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 698936004610 Predicted transcriptional regulator [Transcription]; Region: COG1959 698936004611 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698936004612 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 698936004613 glutathione-disulfide reductase, plant; Region: gluta_reduc_2; TIGR01424 698936004614 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936004615 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698936004616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 698936004617 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 698936004618 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698936004619 active site 698936004620 dimer interface [polypeptide binding]; other site 698936004621 phosphoglycolate phosphatase; Provisional; Region: PRK13222 698936004622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936004623 motif II; other site 698936004624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 698936004625 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698936004626 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698936004627 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698936004628 Class II fumarases; Region: Fumarase_classII; cd01362 698936004629 active site 698936004630 tetramer interface [polypeptide binding]; other site 698936004631 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 698936004632 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936004633 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698936004634 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698936004635 MarR family; Region: MarR_2; pfam12802 698936004636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 698936004637 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 698936004638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698936004639 FeS/SAM binding site; other site 698936004640 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698936004641 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698936004642 EamA-like transporter family; Region: EamA; pfam00892 698936004643 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 698936004644 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698936004645 GTP binding site; other site 698936004646 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 698936004647 Walker A motif; other site 698936004648 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 698936004649 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 698936004650 ligand binding site [chemical binding]; other site 698936004651 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 698936004652 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936004653 substrate binding pocket [chemical binding]; other site 698936004654 membrane-bound complex binding site; other site 698936004655 hinge residues; other site 698936004656 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936004657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936004658 dimer interface [polypeptide binding]; other site 698936004659 conserved gate region; other site 698936004660 putative PBP binding loops; other site 698936004661 ABC-ATPase subunit interface; other site 698936004662 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936004663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936004664 dimer interface [polypeptide binding]; other site 698936004665 conserved gate region; other site 698936004666 putative PBP binding loops; other site 698936004667 ABC-ATPase subunit interface; other site 698936004668 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 698936004669 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 698936004670 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 698936004671 putative NAD(P) binding site [chemical binding]; other site 698936004672 putative active site [active] 698936004673 Predicted integral membrane protein [Function unknown]; Region: COG5530 698936004674 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 698936004675 Tetratricopeptide repeat; Region: TPR_1; pfam00515 698936004676 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 698936004677 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698936004678 NAD(P) binding pocket [chemical binding]; other site 698936004679 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698936004680 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 698936004681 A new structural DNA glycosylase; Region: AlkD_like; cd06561 698936004682 active site 698936004683 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936004684 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936004685 putative DNA binding site [nucleotide binding]; other site 698936004686 putative Zn2+ binding site [ion binding]; other site 698936004687 AsnC family; Region: AsnC_trans_reg; pfam01037 698936004688 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 698936004689 putative uracil binding site [chemical binding]; other site 698936004690 putative active site [active] 698936004691 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 698936004692 Catalytic site; other site 698936004693 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 698936004694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936004695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936004696 dimer interface [polypeptide binding]; other site 698936004697 phosphorylation site [posttranslational modification] 698936004698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936004699 ATP binding site [chemical binding]; other site 698936004700 Mg2+ binding site [ion binding]; other site 698936004701 G-X-G motif; other site 698936004702 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 698936004703 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 698936004704 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 698936004705 putative dimer interface [polypeptide binding]; other site 698936004706 active site pocket [active] 698936004707 putative cataytic base [active] 698936004708 cobalamin synthase; Reviewed; Region: cobS; PRK00235 698936004709 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 698936004710 Predicted aspartyl protease [General function prediction only]; Region: COG3577 698936004711 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 698936004712 catalytic motif [active] 698936004713 Catalytic residue [active] 698936004714 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698936004715 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 698936004716 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698936004717 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698936004718 Walker A/P-loop; other site 698936004719 ATP binding site [chemical binding]; other site 698936004720 Q-loop/lid; other site 698936004721 ABC transporter signature motif; other site 698936004722 Walker B; other site 698936004723 D-loop; other site 698936004724 H-loop/switch region; other site 698936004725 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936004726 dimerization interface [polypeptide binding]; other site 698936004727 putative DNA binding site [nucleotide binding]; other site 698936004728 putative Zn2+ binding site [ion binding]; other site 698936004729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 698936004730 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 698936004731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 698936004732 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 698936004733 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097 698936004734 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097 698936004735 Cache domain; Region: Cache_2; pfam08269 698936004736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698936004737 dimerization interface [polypeptide binding]; other site 698936004738 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698936004739 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698936004740 dimer interface [polypeptide binding]; other site 698936004741 putative CheW interface [polypeptide binding]; other site 698936004742 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 698936004743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169 698936004744 excinuclease ABC subunit B; Provisional; Region: PRK05298 698936004745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698936004746 ATP binding site [chemical binding]; other site 698936004747 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698936004748 nucleotide binding region [chemical binding]; other site 698936004749 ATP-binding site [chemical binding]; other site 698936004750 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698936004751 UvrB/uvrC motif; Region: UVR; pfam02151 698936004752 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698936004753 HSP70 interaction site [polypeptide binding]; other site 698936004754 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698936004755 DNA-binding site [nucleotide binding]; DNA binding site 698936004756 RNA-binding motif; other site 698936004757 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 698936004758 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698936004759 FMN binding site [chemical binding]; other site 698936004760 active site 698936004761 catalytic residues [active] 698936004762 substrate binding site [chemical binding]; other site 698936004763 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698936004764 active site 698936004765 DNA binding site [nucleotide binding] 698936004766 Int/Topo IB signature motif; other site 698936004767 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 698936004768 DNA methylase; Region: N6_N4_Mtase; pfam01555 698936004769 DNA methylase; Region: N6_N4_Mtase; cl17433 698936004770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936004771 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 698936004772 Walker A motif; other site 698936004773 ATP binding site [chemical binding]; other site 698936004774 Walker B motif; other site 698936004775 arginine finger; other site 698936004776 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 698936004777 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 698936004778 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 698936004779 active site 698936004780 DNA binding site [nucleotide binding] 698936004781 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 698936004782 DNA binding site [nucleotide binding] 698936004783 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 698936004784 Predicted chitinase [General function prediction only]; Region: COG3179 698936004785 catalytic residue [active] 698936004786 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698936004787 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 698936004788 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 698936004789 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 698936004790 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; cl09774 698936004791 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 698936004792 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 698936004793 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 698936004794 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 698936004795 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 698936004796 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 698936004797 tandem repeat interface [polypeptide binding]; other site 698936004798 oligomer interface [polypeptide binding]; other site 698936004799 active site residues [active] 698936004800 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 698936004801 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 698936004802 gpW; Region: gpW; pfam02831 698936004803 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 698936004804 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615 698936004805 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 698936004806 Transcription antiterminator [Transcription]; Region: NusG; COG0250 698936004807 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698936004808 heterodimer interface [polypeptide binding]; other site 698936004809 homodimer interface [polypeptide binding]; other site 698936004810 Helix-turn-helix domain; Region: HTH_36; pfam13730 698936004811 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 698936004812 MT-A70; Region: MT-A70; cl01947 698936004813 Predicted transcriptional regulator [Transcription]; Region: COG2932 698936004814 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698936004815 Catalytic site [active] 698936004816 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 698936004817 HNH endonuclease; Region: HNH_3; pfam13392 698936004818 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 698936004819 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698936004820 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936004821 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 698936004822 catalytic site [active] 698936004823 Sterile alpha motif; Region: SAM; smart00454 698936004824 SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487 698936004825 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 698936004826 cyclase homology domain; Region: CHD; cd07302 698936004827 nucleotidyl binding site; other site 698936004828 metal binding site [ion binding]; metal-binding site 698936004829 dimer interface [polypeptide binding]; other site 698936004830 AAA ATPase domain; Region: AAA_16; pfam13191 698936004831 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 698936004832 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698936004833 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698936004834 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698936004835 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 698936004836 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 698936004837 trimer interface [polypeptide binding]; other site 698936004838 putative metal binding site [ion binding]; other site 698936004839 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698936004840 metal binding site 2 [ion binding]; metal-binding site 698936004841 putative DNA binding helix; other site 698936004842 metal binding site 1 [ion binding]; metal-binding site 698936004843 dimer interface [polypeptide binding]; other site 698936004844 structural Zn2+ binding site [ion binding]; other site 698936004845 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698936004846 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698936004847 ABC-ATPase subunit interface; other site 698936004848 dimer interface [polypeptide binding]; other site 698936004849 putative PBP binding regions; other site 698936004850 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698936004851 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698936004852 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 698936004853 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 698936004854 metal binding site [ion binding]; metal-binding site 698936004855 Predicted integral membrane protein [Function unknown]; Region: COG5455 698936004856 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 698936004857 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 698936004858 inhibitor binding site; inhibition site 698936004859 active site 698936004860 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 698936004861 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 698936004862 DctM-like transporters; Region: DctM; pfam06808 698936004863 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 698936004864 Helix-turn-helix domain; Region: HTH_28; pfam13518 698936004865 Winged helix-turn helix; Region: HTH_29; pfam13551 698936004866 Homeodomain-like domain; Region: HTH_32; pfam13565 698936004867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698936004868 Integrase core domain; Region: rve; pfam00665 698936004869 Integrase core domain; Region: rve_3; pfam13683 698936004870 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 698936004871 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 698936004872 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936004873 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936004874 active site 698936004875 catalytic tetrad [active] 698936004876 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936004877 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936004878 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936004879 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 698936004880 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 698936004881 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 698936004882 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 698936004883 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698936004884 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936004885 Walker A/P-loop; other site 698936004886 ATP binding site [chemical binding]; other site 698936004887 Q-loop/lid; other site 698936004888 ABC transporter signature motif; other site 698936004889 Walker B; other site 698936004890 D-loop; other site 698936004891 H-loop/switch region; other site 698936004892 TOBE domain; Region: TOBE; pfam03459 698936004893 TOBE domain; Region: TOBE_2; pfam08402 698936004894 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936004895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936004896 dimer interface [polypeptide binding]; other site 698936004897 conserved gate region; other site 698936004898 putative PBP binding loops; other site 698936004899 ABC-ATPase subunit interface; other site 698936004900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936004901 dimer interface [polypeptide binding]; other site 698936004902 conserved gate region; other site 698936004903 putative PBP binding loops; other site 698936004904 ABC-ATPase subunit interface; other site 698936004905 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936004906 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936004907 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936004908 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936004909 DNA binding site [nucleotide binding] 698936004910 domain linker motif; other site 698936004911 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 698936004912 ligand binding site [chemical binding]; other site 698936004913 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 698936004914 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698936004915 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698936004916 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698936004917 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 698936004918 Helix-turn-helix domain; Region: HTH_18; pfam12833 698936004919 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698936004920 hydrophobic ligand binding site; other site 698936004921 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936004922 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698936004923 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698936004924 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698936004925 putative acyl-acceptor binding pocket; other site 698936004926 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698936004927 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 698936004928 putative NAD(P) binding site [chemical binding]; other site 698936004929 structural Zn binding site [ion binding]; other site 698936004930 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 698936004931 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 698936004932 dimer interface [polypeptide binding]; other site 698936004933 active site 698936004934 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 698936004935 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 698936004936 active site 698936004937 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 698936004938 active site 2 [active] 698936004939 active site 1 [active] 698936004940 acyl carrier protein; Provisional; Region: PRK06508 698936004941 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 698936004942 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 698936004943 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936004944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936004945 homodimer interface [polypeptide binding]; other site 698936004946 catalytic residue [active] 698936004947 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 698936004948 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 698936004949 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698936004950 active site 698936004951 SAM binding site [chemical binding]; other site 698936004952 homodimer interface [polypeptide binding]; other site 698936004953 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 698936004954 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 698936004955 hypothetical protein; Provisional; Region: PRK10621 698936004956 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698936004957 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698936004958 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936004959 Walker A/P-loop; other site 698936004960 ATP binding site [chemical binding]; other site 698936004961 Q-loop/lid; other site 698936004962 ABC transporter signature motif; other site 698936004963 Walker B; other site 698936004964 D-loop; other site 698936004965 H-loop/switch region; other site 698936004966 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936004967 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936004968 Walker A/P-loop; other site 698936004969 ATP binding site [chemical binding]; other site 698936004970 Q-loop/lid; other site 698936004971 ABC transporter signature motif; other site 698936004972 Walker B; other site 698936004973 D-loop; other site 698936004974 H-loop/switch region; other site 698936004975 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698936004976 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 698936004977 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936004978 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698936004979 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936004980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936004981 dimer interface [polypeptide binding]; other site 698936004982 conserved gate region; other site 698936004983 putative PBP binding loops; other site 698936004984 ABC-ATPase subunit interface; other site 698936004985 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698936004986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936004987 dimer interface [polypeptide binding]; other site 698936004988 conserved gate region; other site 698936004989 putative PBP binding loops; other site 698936004990 ABC-ATPase subunit interface; other site 698936004991 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 698936004992 ANTAR domain; Region: ANTAR; pfam03861 698936004993 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 698936004994 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 698936004995 ligand binding site [chemical binding]; other site 698936004996 regulator interaction site; other site 698936004997 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 698936004998 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 698936004999 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 698936005000 homodimer interface [polypeptide binding]; other site 698936005001 Walker A motif; other site 698936005002 ATP binding site [chemical binding]; other site 698936005003 hydroxycobalamin binding site [chemical binding]; other site 698936005004 Walker B motif; other site 698936005005 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698936005006 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698936005007 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698936005008 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 698936005009 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698936005010 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 698936005011 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 698936005012 homotrimer interface [polypeptide binding]; other site 698936005013 Walker A motif; other site 698936005014 GTP binding site [chemical binding]; other site 698936005015 Walker B motif; other site 698936005016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 698936005017 FecR protein; Region: FecR; pfam04773 698936005018 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 698936005019 CHASE2 domain; Region: CHASE2; pfam05226 698936005020 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936005021 cyclase homology domain; Region: CHD; cd07302 698936005022 nucleotidyl binding site; other site 698936005023 metal binding site [ion binding]; metal-binding site 698936005024 dimer interface [polypeptide binding]; other site 698936005025 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698936005026 cobyric acid synthase; Provisional; Region: PRK00784 698936005027 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698936005028 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698936005029 catalytic triad [active] 698936005030 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 698936005031 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698936005032 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 698936005033 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 698936005034 Walker A/P-loop; other site 698936005035 ATP binding site [chemical binding]; other site 698936005036 Q-loop/lid; other site 698936005037 ABC transporter signature motif; other site 698936005038 Walker B; other site 698936005039 D-loop; other site 698936005040 H-loop/switch region; other site 698936005041 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 698936005042 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 698936005043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936005044 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936005045 dimerization interface [polypeptide binding]; other site 698936005046 methionine synthase I; Validated; Region: PRK07534 698936005047 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 698936005048 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 698936005049 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936005050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936005051 homodimer interface [polypeptide binding]; other site 698936005052 catalytic residue [active] 698936005053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 698936005054 YheO-like PAS domain; Region: PAS_6; pfam08348 698936005055 HTH domain; Region: HTH_22; pfam13309 698936005056 Predicted periplasmic protein [Function unknown]; Region: COG3698 698936005057 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 698936005058 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 698936005059 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 698936005060 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 698936005061 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 698936005062 B12 binding site [chemical binding]; other site 698936005063 cobalt ligand [ion binding]; other site 698936005064 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 698936005065 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 698936005066 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 698936005067 putative active site [active] 698936005068 putative cosubstrate binding site; other site 698936005069 putative substrate binding site [chemical binding]; other site 698936005070 catalytic site [active] 698936005071 BA14K-like protein; Region: BA14K; pfam07886 698936005072 Virulence factor; Region: Virulence_fact; pfam13769 698936005073 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 698936005074 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698936005075 FAD binding site [chemical binding]; other site 698936005076 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 698936005077 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 698936005078 substrate binding pocket [chemical binding]; other site 698936005079 dimer interface [polypeptide binding]; other site 698936005080 inhibitor binding site; inhibition site 698936005081 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 698936005082 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936005083 catalytic loop [active] 698936005084 iron binding site [ion binding]; other site 698936005085 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 698936005086 AAA domain; Region: AAA_33; pfam13671 698936005087 P-loop motif; other site 698936005088 ATP binding site [chemical binding]; other site 698936005089 Chloramphenicol (Cm) binding site [chemical binding]; other site 698936005090 catalytic residue [active] 698936005091 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 698936005092 putative hydrophobic ligand binding site [chemical binding]; other site 698936005093 CLM binding site; other site 698936005094 L1 loop; other site 698936005095 DNA binding site [nucleotide binding] 698936005096 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936005097 dimerization interface [polypeptide binding]; other site 698936005098 putative DNA binding site [nucleotide binding]; other site 698936005099 putative Zn2+ binding site [ion binding]; other site 698936005100 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936005101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936005102 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936005103 dimerization interface [polypeptide binding]; other site 698936005104 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698936005105 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 698936005106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 698936005107 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 698936005108 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698936005109 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698936005110 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 698936005111 putative metal binding site [ion binding]; other site 698936005112 putative homodimer interface [polypeptide binding]; other site 698936005113 putative homotetramer interface [polypeptide binding]; other site 698936005114 putative homodimer-homodimer interface [polypeptide binding]; other site 698936005115 putative allosteric switch controlling residues; other site 698936005116 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 698936005117 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 698936005118 conserved cys residue [active] 698936005119 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936005120 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698936005121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936005122 active site 698936005123 phosphorylation site [posttranslational modification] 698936005124 intermolecular recognition site; other site 698936005125 dimerization interface [polypeptide binding]; other site 698936005126 Response regulator receiver domain; Region: Response_reg; pfam00072 698936005127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936005128 active site 698936005129 phosphorylation site [posttranslational modification] 698936005130 intermolecular recognition site; other site 698936005131 dimerization interface [polypeptide binding]; other site 698936005132 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 698936005133 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936005134 cyclase homology domain; Region: CHD; cd07302 698936005135 nucleotidyl binding site; other site 698936005136 metal binding site [ion binding]; metal-binding site 698936005137 dimer interface [polypeptide binding]; other site 698936005138 RibD C-terminal domain; Region: RibD_C; cl17279 698936005139 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698936005140 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 698936005141 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 698936005142 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698936005143 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698936005144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 698936005145 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 698936005146 transmembrane helices; other site 698936005147 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698936005148 TrkA-C domain; Region: TrkA_C; pfam02080 698936005149 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698936005150 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 698936005151 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698936005152 catalytic residue [active] 698936005153 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698936005154 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698936005155 active site 698936005156 Terminase-like family; Region: Terminase_6; pfam03237 698936005157 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 698936005158 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698936005159 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 698936005160 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698936005161 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 698936005162 Transposase [DNA replication, recombination, and repair]; Region: COG5433 698936005163 BA14K-like protein; Region: BA14K; pfam07886 698936005164 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698936005165 DnaA box-binding interface [nucleotide binding]; other site 698936005166 Predicted transcriptional regulator [Transcription]; Region: COG2932 698936005167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936005168 non-specific DNA binding site [nucleotide binding]; other site 698936005169 salt bridge; other site 698936005170 sequence-specific DNA binding site [nucleotide binding]; other site 698936005171 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698936005172 Catalytic site [active] 698936005173 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 698936005174 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 698936005175 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 698936005176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 698936005177 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698936005178 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 698936005179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936005180 DNA binding residues [nucleotide binding] 698936005181 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 698936005182 FecR protein; Region: FecR; pfam04773 698936005183 Secretin and TonB N terminus short domain; Region: STN; smart00965 698936005184 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 698936005185 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 698936005186 N-terminal plug; other site 698936005187 ligand-binding site [chemical binding]; other site 698936005188 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 698936005189 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936005190 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 698936005191 Walker A/P-loop; other site 698936005192 ATP binding site [chemical binding]; other site 698936005193 Q-loop/lid; other site 698936005194 ABC transporter signature motif; other site 698936005195 Walker B; other site 698936005196 D-loop; other site 698936005197 H-loop/switch region; other site 698936005198 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 698936005199 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936005200 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 698936005201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 698936005202 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 698936005203 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 698936005204 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 698936005205 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698936005206 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 698936005207 nudix motif; other site 698936005208 putative catalytic site [active] 698936005209 putative phosphate binding site [ion binding]; other site 698936005210 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698936005211 putative metal binding site [ion binding]; other site 698936005212 TIGR02594 family protein; Region: TIGR02594 698936005213 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 698936005214 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 698936005215 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 698936005216 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 698936005217 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 698936005218 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 698936005219 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936005220 cyclase homology domain; Region: CHD; cd07302 698936005221 nucleotidyl binding site; other site 698936005222 metal binding site [ion binding]; metal-binding site 698936005223 dimer interface [polypeptide binding]; other site 698936005224 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936005225 TPR repeat; Region: TPR_11; pfam13414 698936005226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936005227 binding surface 698936005228 TPR motif; other site 698936005229 cell division protein FtsZ; Provisional; Region: PRK13018 698936005230 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698936005231 nucleotide binding site [chemical binding]; other site 698936005232 SulA interaction site; other site 698936005233 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 698936005234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936005235 active site 698936005236 motif I; other site 698936005237 motif II; other site 698936005238 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698936005239 AAA ATPase domain; Region: AAA_16; pfam13191 698936005240 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698936005241 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698936005242 Walker A/P-loop; other site 698936005243 ATP binding site [chemical binding]; other site 698936005244 Q-loop/lid; other site 698936005245 ABC transporter signature motif; other site 698936005246 Walker B; other site 698936005247 D-loop; other site 698936005248 H-loop/switch region; other site 698936005249 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 698936005250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936005251 dimer interface [polypeptide binding]; other site 698936005252 conserved gate region; other site 698936005253 putative PBP binding loops; other site 698936005254 ABC-ATPase subunit interface; other site 698936005255 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698936005256 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698936005257 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698936005258 DNA-binding site [nucleotide binding]; DNA binding site 698936005259 RNA-binding motif; other site 698936005260 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 698936005261 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936005262 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 698936005263 C-terminal domain interface [polypeptide binding]; other site 698936005264 GSH binding site (G-site) [chemical binding]; other site 698936005265 dimer interface [polypeptide binding]; other site 698936005266 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 698936005267 N-terminal domain interface [polypeptide binding]; other site 698936005268 dimer interface [polypeptide binding]; other site 698936005269 substrate binding pocket (H-site) [chemical binding]; other site 698936005270 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936005271 active site 698936005272 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936005273 catalytic tetrad [active] 698936005274 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 698936005275 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698936005276 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 698936005277 Transposase [DNA replication, recombination, and repair]; Region: COG5433 698936005278 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 698936005279 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936005280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936005281 homodimer interface [polypeptide binding]; other site 698936005282 catalytic residue [active] 698936005283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698936005284 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698936005285 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 698936005286 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698936005287 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936005288 cyclase homology domain; Region: CHD; cd07302 698936005289 nucleotidyl binding site; other site 698936005290 metal binding site [ion binding]; metal-binding site 698936005291 dimer interface [polypeptide binding]; other site 698936005292 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698936005293 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698936005294 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698936005295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936005296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936005297 macrolide transporter subunit MacA; Provisional; Region: PRK11578 698936005298 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936005299 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 698936005300 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698936005301 Walker A/P-loop; other site 698936005302 ATP binding site [chemical binding]; other site 698936005303 Q-loop/lid; other site 698936005304 ABC transporter signature motif; other site 698936005305 Walker B; other site 698936005306 D-loop; other site 698936005307 H-loop/switch region; other site 698936005308 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698936005309 FtsX-like permease family; Region: FtsX; pfam02687 698936005310 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 698936005311 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 698936005312 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 698936005313 Catalytic site; other site 698936005314 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 698936005315 Phosphotransferase enzyme family; Region: APH; pfam01636 698936005316 putative active site [active] 698936005317 putative substrate binding site [chemical binding]; other site 698936005318 ATP binding site [chemical binding]; other site 698936005319 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 698936005320 benzoate transport; Region: 2A0115; TIGR00895 698936005321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936005322 putative substrate translocation pore; other site 698936005323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936005324 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698936005325 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698936005326 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698936005327 putative active site [active] 698936005328 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698936005329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936005330 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936005331 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936005332 putative DNA binding site [nucleotide binding]; other site 698936005333 putative Zn2+ binding site [ion binding]; other site 698936005334 AsnC family; Region: AsnC_trans_reg; pfam01037 698936005335 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 698936005336 aspartate racemase; Region: asp_race; TIGR00035 698936005337 Predicted transcriptional regulators [Transcription]; Region: COG1733 698936005338 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 698936005339 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698936005340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936005341 NAD(P) binding site [chemical binding]; other site 698936005342 active site 698936005343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 698936005344 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698936005345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936005346 DNA-binding site [nucleotide binding]; DNA binding site 698936005347 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936005348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936005349 homodimer interface [polypeptide binding]; other site 698936005350 catalytic residue [active] 698936005351 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 698936005352 active site 698936005353 hydrophilic channel; other site 698936005354 dimerization interface [polypeptide binding]; other site 698936005355 catalytic residues [active] 698936005356 active site lid [active] 698936005357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 698936005358 EF-hand domain pair; Region: EF_hand_5; pfam13499 698936005359 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 698936005360 Ca2+ binding site [ion binding]; other site 698936005361 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 698936005362 Zn binding site [ion binding]; other site 698936005363 Uncharacterized conserved protein [Function unknown]; Region: COG3482 698936005364 YcaO-like family; Region: YcaO; pfam02624 698936005365 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698936005366 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 698936005367 cyclase homology domain; Region: CHD; cd07302 698936005368 nucleotidyl binding site; other site 698936005369 metal binding site [ion binding]; metal-binding site 698936005370 dimer interface [polypeptide binding]; other site 698936005371 Predicted ATPase [General function prediction only]; Region: COG3899 698936005372 AAA ATPase domain; Region: AAA_16; pfam13191 698936005373 Predicted ATPase [General function prediction only]; Region: COG3903 698936005374 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 698936005375 AAA domain; Region: AAA_30; pfam13604 698936005376 Family description; Region: UvrD_C_2; pfam13538 698936005377 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 698936005378 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698936005379 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698936005380 Predicted transcriptional regulator [Transcription]; Region: COG4190 698936005381 Helix-turn-helix domain; Region: HTH_20; pfam12840 698936005382 putative DNA binding site [nucleotide binding]; other site 698936005383 putative Zn2+ binding site [ion binding]; other site 698936005384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 698936005385 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 698936005386 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 698936005387 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 698936005388 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698936005389 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936005390 DNA binding residues [nucleotide binding] 698936005391 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 698936005392 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 698936005393 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 698936005394 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 698936005395 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 698936005396 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 698936005397 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698936005398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936005399 S-adenosylmethionine binding site [chemical binding]; other site 698936005400 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698936005401 DNA-binding site [nucleotide binding]; DNA binding site 698936005402 RNA-binding motif; other site 698936005403 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936005404 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936005405 active site 698936005406 catalytic tetrad [active] 698936005407 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698936005408 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698936005409 putative valine binding site [chemical binding]; other site 698936005410 dimer interface [polypeptide binding]; other site 698936005411 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698936005412 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 698936005413 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698936005414 PYR/PP interface [polypeptide binding]; other site 698936005415 dimer interface [polypeptide binding]; other site 698936005416 TPP binding site [chemical binding]; other site 698936005417 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698936005418 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698936005419 TPP-binding site [chemical binding]; other site 698936005420 dimer interface [polypeptide binding]; other site 698936005421 HAS barrel domain; Region: HAS-barrel; pfam09378 698936005422 HerA helicase [Replication, recombination, and repair]; Region: COG0433 698936005423 Domain of unknown function DUF87; Region: DUF87; pfam01935 698936005424 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698936005425 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698936005426 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698936005427 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698936005428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936005429 motif II; other site 698936005430 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698936005431 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698936005432 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 698936005433 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698936005434 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698936005435 protein binding site [polypeptide binding]; other site 698936005436 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698936005437 protein binding site [polypeptide binding]; other site 698936005438 Uncharacterized conserved protein [Function unknown]; Region: COG3603 698936005439 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698936005440 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 698936005441 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698936005442 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 698936005443 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 698936005444 HflK protein; Region: hflK; TIGR01933 698936005445 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698936005446 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698936005447 folate binding site [chemical binding]; other site 698936005448 NADP+ binding site [chemical binding]; other site 698936005449 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936005450 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 698936005451 putative C-terminal domain interface [polypeptide binding]; other site 698936005452 putative GSH binding site (G-site) [chemical binding]; other site 698936005453 putative dimer interface [polypeptide binding]; other site 698936005454 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 698936005455 dimer interface [polypeptide binding]; other site 698936005456 N-terminal domain interface [polypeptide binding]; other site 698936005457 putative substrate binding pocket (H-site) [chemical binding]; other site 698936005458 thymidylate synthase; Reviewed; Region: thyA; PRK01827 698936005459 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698936005460 dimerization interface [polypeptide binding]; other site 698936005461 active site 698936005462 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 698936005463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 698936005464 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 698936005465 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 698936005466 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 698936005467 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 698936005468 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698936005469 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 698936005470 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 698936005471 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698936005472 FAD binding domain; Region: FAD_binding_4; pfam01565 698936005473 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 698936005474 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698936005475 Protein export membrane protein; Region: SecD_SecF; cl14618 698936005476 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698936005477 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936005478 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936005479 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 698936005480 Uncharacterized conserved protein [Function unknown]; Region: COG2128 698936005481 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698936005482 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698936005483 Part of AAA domain; Region: AAA_19; pfam13245 698936005484 Family description; Region: UvrD_C_2; pfam13538 698936005485 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698936005486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936005487 Coenzyme A binding pocket [chemical binding]; other site 698936005488 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926 698936005489 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936005490 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936005491 metal binding site [ion binding]; metal-binding site 698936005492 active site 698936005493 I-site; other site 698936005494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 698936005495 CreA protein; Region: CreA; pfam05981 698936005496 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 698936005497 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 698936005498 putative CheA interaction surface; other site 698936005499 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698936005500 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698936005501 dimer interface [polypeptide binding]; other site 698936005502 putative CheW interface [polypeptide binding]; other site 698936005503 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 698936005504 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 698936005505 Cu(I) binding site [ion binding]; other site 698936005506 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 698936005507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936005508 S-adenosylmethionine binding site [chemical binding]; other site 698936005509 Protein of unknown function (DUF968); Region: DUF968; pfam06147 698936005510 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698936005511 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698936005512 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 698936005513 active site 698936005514 Nuclear pore component; Region: Nup88; pfam10168 698936005515 Predicted membrane protein [Function unknown]; Region: COG4541 698936005516 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698936005517 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698936005518 oligomerization interface [polypeptide binding]; other site 698936005519 active site 698936005520 metal binding site [ion binding]; metal-binding site 698936005521 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698936005522 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698936005523 active site 698936005524 ATP-binding site [chemical binding]; other site 698936005525 pantoate-binding site; other site 698936005526 HXXH motif; other site 698936005527 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 698936005528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936005529 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698936005530 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698936005531 nucleotide binding pocket [chemical binding]; other site 698936005532 K-X-D-G motif; other site 698936005533 catalytic site [active] 698936005534 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698936005535 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698936005536 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698936005537 Dimer interface [polypeptide binding]; other site 698936005538 BRCT sequence motif; other site 698936005539 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698936005540 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698936005541 Walker A/P-loop; other site 698936005542 ATP binding site [chemical binding]; other site 698936005543 Q-loop/lid; other site 698936005544 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698936005545 ABC transporter signature motif; other site 698936005546 Walker B; other site 698936005547 D-loop; other site 698936005548 H-loop/switch region; other site 698936005549 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 698936005550 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 698936005551 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 698936005552 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 698936005553 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698936005554 nucleotide binding site [chemical binding]; other site 698936005555 SulA interaction site; other site 698936005556 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 698936005557 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 698936005558 Cell division protein FtsA; Region: FtsA; smart00842 698936005559 Cell division protein FtsA; Region: FtsA; pfam14450 698936005560 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 698936005561 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698936005562 Cell division protein FtsQ; Region: FtsQ; pfam03799 698936005563 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 698936005564 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698936005565 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698936005566 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 698936005567 amphipathic channel; other site 698936005568 Asn-Pro-Ala signature motifs; other site 698936005569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936005570 metabolite-proton symporter; Region: 2A0106; TIGR00883 698936005571 putative substrate translocation pore; other site 698936005572 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 698936005573 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698936005574 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698936005575 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698936005576 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698936005577 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698936005578 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698936005579 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698936005580 homodimer interface [polypeptide binding]; other site 698936005581 active site 698936005582 cell division protein FtsW; Region: ftsW; TIGR02614 698936005583 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 698936005584 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698936005585 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698936005586 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698936005587 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698936005588 Mg++ binding site [ion binding]; other site 698936005589 putative catalytic motif [active] 698936005590 putative substrate binding site [chemical binding]; other site 698936005591 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698936005592 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698936005593 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698936005594 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698936005595 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698936005596 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698936005597 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698936005598 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698936005599 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698936005600 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698936005601 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698936005602 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 698936005603 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 698936005604 MraW methylase family; Region: Methyltransf_5; cl17771 698936005605 cell division protein MraZ; Reviewed; Region: PRK00326 698936005606 MraZ protein; Region: MraZ; pfam02381 698936005607 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936005608 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 698936005609 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698936005610 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698936005611 catalytic residue [active] 698936005612 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 698936005613 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698936005614 amidase catalytic site [active] 698936005615 Zn binding residues [ion binding]; other site 698936005616 substrate binding site [chemical binding]; other site 698936005617 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698936005618 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 698936005619 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 698936005620 putative metal binding site [ion binding]; other site 698936005621 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698936005622 HSP70 interaction site [polypeptide binding]; other site 698936005623 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 698936005624 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 698936005625 active site 698936005626 ADP/pyrophosphate binding site [chemical binding]; other site 698936005627 allosteric effector site; other site 698936005628 dimerization interface [polypeptide binding]; other site 698936005629 fructose-1,6-bisphosphate binding site; other site 698936005630 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698936005631 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 698936005632 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698936005633 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698936005634 catalytic residue [active] 698936005635 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698936005636 Beta-lactamase; Region: Beta-lactamase; pfam00144 698936005637 S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379 698936005638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936005639 S-adenosylmethionine binding site [chemical binding]; other site 698936005640 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 698936005641 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 698936005642 active site 698936005643 lytic murein transglycosylase; Region: MltB_2; TIGR02283 698936005644 murein hydrolase B; Provisional; Region: PRK10760; cl17906 698936005645 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698936005646 EamA-like transporter family; Region: EamA; cl17759 698936005647 EamA-like transporter family; Region: EamA; pfam00892 698936005648 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698936005649 FAD binding site [chemical binding]; other site 698936005650 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936005651 dimerization interface [polypeptide binding]; other site 698936005652 putative DNA binding site [nucleotide binding]; other site 698936005653 putative Zn2+ binding site [ion binding]; other site 698936005654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936005655 S-adenosylmethionine binding site [chemical binding]; other site 698936005656 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 698936005657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936005658 Walker A/P-loop; other site 698936005659 ATP binding site [chemical binding]; other site 698936005660 Q-loop/lid; other site 698936005661 ABC transporter signature motif; other site 698936005662 Walker B; other site 698936005663 D-loop; other site 698936005664 H-loop/switch region; other site 698936005665 ABC transporter; Region: ABC_tran_2; pfam12848 698936005666 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698936005667 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 698936005668 B1 nucleotide binding pocket [chemical binding]; other site 698936005669 B2 nucleotide binding pocket [chemical binding]; other site 698936005670 CAS motifs; other site 698936005671 active site 698936005672 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698936005673 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936005674 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698936005675 EamA-like transporter family; Region: EamA; pfam00892 698936005676 thiamine pyrophosphate protein; Validated; Region: PRK08199 698936005677 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698936005678 PYR/PP interface [polypeptide binding]; other site 698936005679 dimer interface [polypeptide binding]; other site 698936005680 TPP binding site [chemical binding]; other site 698936005681 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698936005682 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 698936005683 TPP-binding site [chemical binding]; other site 698936005684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 698936005685 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 698936005686 active site 698936005687 catalytic residues [active] 698936005688 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698936005689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698936005690 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698936005691 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698936005692 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936005693 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698936005694 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698936005695 P-loop; other site 698936005696 Magnesium ion binding site [ion binding]; other site 698936005697 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 698936005698 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 698936005699 putative active site [active] 698936005700 metal binding site [ion binding]; metal-binding site 698936005701 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 698936005702 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 698936005703 NAD(P) binding site [chemical binding]; other site 698936005704 catalytic residues [active] 698936005705 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698936005706 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698936005707 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 698936005708 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 698936005709 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698936005710 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698936005711 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698936005712 putative active site [active] 698936005713 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698936005714 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698936005715 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936005716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936005717 dimer interface [polypeptide binding]; other site 698936005718 conserved gate region; other site 698936005719 putative PBP binding loops; other site 698936005720 ABC-ATPase subunit interface; other site 698936005721 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936005722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936005723 dimer interface [polypeptide binding]; other site 698936005724 conserved gate region; other site 698936005725 putative PBP binding loops; other site 698936005726 ABC-ATPase subunit interface; other site 698936005727 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698936005728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936005729 Walker A/P-loop; other site 698936005730 ATP binding site [chemical binding]; other site 698936005731 Q-loop/lid; other site 698936005732 ABC transporter signature motif; other site 698936005733 Walker B; other site 698936005734 D-loop; other site 698936005735 H-loop/switch region; other site 698936005736 TOBE domain; Region: TOBE_2; pfam08402 698936005737 riboflavin synthase subunit beta; Provisional; Region: PRK12419 698936005738 active site 698936005739 homopentamer interface [polypeptide binding]; other site 698936005740 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698936005741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936005742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936005743 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 698936005744 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 698936005745 N-terminal plug; other site 698936005746 ligand-binding site [chemical binding]; other site 698936005747 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698936005748 MULE transposase domain; Region: MULE; pfam10551 698936005749 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698936005750 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698936005751 substrate binding site [chemical binding]; other site 698936005752 dimer interface [polypeptide binding]; other site 698936005753 triosephosphate isomerase; Provisional; Region: PRK14565 698936005754 catalytic triad [active] 698936005755 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698936005756 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 698936005757 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698936005758 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 698936005759 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 698936005760 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698936005761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936005762 active site 698936005763 motif I; other site 698936005764 motif II; other site 698936005765 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 698936005766 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698936005767 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698936005768 nucleotide binding site [chemical binding]; other site 698936005769 Uncharacterized conserved protein [Function unknown]; Region: COG3347 698936005770 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 698936005771 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 698936005772 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 698936005773 intersubunit interface [polypeptide binding]; other site 698936005774 active site 698936005775 Zn2+ binding site [ion binding]; other site 698936005776 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698936005777 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 698936005778 putative ligand binding site [chemical binding]; other site 698936005779 putative NAD binding site [chemical binding]; other site 698936005780 catalytic site [active] 698936005781 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698936005782 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 698936005783 putative N- and C-terminal domain interface [polypeptide binding]; other site 698936005784 putative active site [active] 698936005785 MgATP binding site [chemical binding]; other site 698936005786 catalytic site [active] 698936005787 metal binding site [ion binding]; metal-binding site 698936005788 putative xylulose binding site [chemical binding]; other site 698936005789 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698936005790 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698936005791 Walker A/P-loop; other site 698936005792 ATP binding site [chemical binding]; other site 698936005793 Q-loop/lid; other site 698936005794 ABC transporter signature motif; other site 698936005795 Walker B; other site 698936005796 D-loop; other site 698936005797 H-loop/switch region; other site 698936005798 TOBE domain; Region: TOBE_2; pfam08402 698936005799 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698936005800 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936005801 Walker A/P-loop; other site 698936005802 ATP binding site [chemical binding]; other site 698936005803 Q-loop/lid; other site 698936005804 ABC transporter signature motif; other site 698936005805 Walker B; other site 698936005806 D-loop; other site 698936005807 H-loop/switch region; other site 698936005808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698936005809 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936005810 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698936005811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936005812 dimer interface [polypeptide binding]; other site 698936005813 conserved gate region; other site 698936005814 putative PBP binding loops; other site 698936005815 ABC-ATPase subunit interface; other site 698936005816 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936005817 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936005818 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698936005819 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698936005820 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936005821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936005822 DNA binding residues [nucleotide binding] 698936005823 dimerization interface [polypeptide binding]; other site 698936005824 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698936005825 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 698936005826 Walker A/P-loop; other site 698936005827 ATP binding site [chemical binding]; other site 698936005828 Q-loop/lid; other site 698936005829 ABC transporter signature motif; other site 698936005830 Walker B; other site 698936005831 D-loop; other site 698936005832 H-loop/switch region; other site 698936005833 TOBE domain; Region: TOBE_2; pfam08402 698936005834 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698936005835 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698936005836 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936005837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936005838 putative PBP binding loops; other site 698936005839 ABC-ATPase subunit interface; other site 698936005840 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936005841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936005842 dimer interface [polypeptide binding]; other site 698936005843 conserved gate region; other site 698936005844 putative PBP binding loops; other site 698936005845 ABC-ATPase subunit interface; other site 698936005846 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936005847 classical (c) SDRs; Region: SDR_c; cd05233 698936005848 NAD(P) binding site [chemical binding]; other site 698936005849 active site 698936005850 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 698936005851 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 698936005852 conserved cys residue [active] 698936005853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936005854 Uncharacterized conserved protein [Function unknown]; Region: COG3246 698936005855 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531 698936005856 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 698936005857 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 698936005858 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698936005859 active site 698936005860 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698936005861 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698936005862 active site 698936005863 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 698936005864 CoA binding domain; Region: CoA_binding_2; pfam13380 698936005865 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 698936005866 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 698936005867 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 698936005868 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698936005869 substrate binding site [chemical binding]; other site 698936005870 oxyanion hole (OAH) forming residues; other site 698936005871 trimer interface [polypeptide binding]; other site 698936005872 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936005873 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698936005874 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936005875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936005876 dimer interface [polypeptide binding]; other site 698936005877 conserved gate region; other site 698936005878 ABC-ATPase subunit interface; other site 698936005879 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698936005880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936005881 dimer interface [polypeptide binding]; other site 698936005882 conserved gate region; other site 698936005883 ABC-ATPase subunit interface; other site 698936005884 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698936005885 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936005886 Walker A/P-loop; other site 698936005887 ATP binding site [chemical binding]; other site 698936005888 Q-loop/lid; other site 698936005889 ABC transporter signature motif; other site 698936005890 Walker B; other site 698936005891 D-loop; other site 698936005892 H-loop/switch region; other site 698936005893 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936005894 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936005895 Walker A/P-loop; other site 698936005896 ATP binding site [chemical binding]; other site 698936005897 Q-loop/lid; other site 698936005898 ABC transporter signature motif; other site 698936005899 Walker B; other site 698936005900 D-loop; other site 698936005901 H-loop/switch region; other site 698936005902 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936005903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936005904 sequence-specific DNA binding site [nucleotide binding]; other site 698936005905 salt bridge; other site 698936005906 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936005907 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698936005908 Predicted acyl esterases [General function prediction only]; Region: COG2936 698936005909 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698936005910 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 698936005911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 698936005912 ACT domain; Region: ACT_3; pfam10000 698936005913 Family description; Region: ACT_7; pfam13840 698936005914 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698936005915 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936005916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936005917 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 698936005918 putative substrate binding pocket [chemical binding]; other site 698936005919 dimerization interface [polypeptide binding]; other site 698936005920 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698936005921 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698936005922 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698936005923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936005924 Walker A/P-loop; other site 698936005925 ATP binding site [chemical binding]; other site 698936005926 Q-loop/lid; other site 698936005927 ABC transporter signature motif; other site 698936005928 Walker B; other site 698936005929 D-loop; other site 698936005930 H-loop/switch region; other site 698936005931 TOBE domain; Region: TOBE_2; pfam08402 698936005932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936005933 dimer interface [polypeptide binding]; other site 698936005934 conserved gate region; other site 698936005935 putative PBP binding loops; other site 698936005936 ABC-ATPase subunit interface; other site 698936005937 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936005938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936005939 dimer interface [polypeptide binding]; other site 698936005940 conserved gate region; other site 698936005941 putative PBP binding loops; other site 698936005942 ABC-ATPase subunit interface; other site 698936005943 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 698936005944 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 698936005945 tetrameric interface [polypeptide binding]; other site 698936005946 NAD binding site [chemical binding]; other site 698936005947 catalytic residues [active] 698936005948 substrate binding site [chemical binding]; other site 698936005949 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 698936005950 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698936005951 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 698936005952 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698936005953 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698936005954 putative ligand binding residues [chemical binding]; other site 698936005955 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 698936005956 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936005957 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936005958 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 698936005959 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 698936005960 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698936005961 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936005962 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936005963 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 698936005964 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698936005965 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936005966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936005967 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698936005968 dimerization interface [polypeptide binding]; other site 698936005969 Predicted membrane protein [Function unknown]; Region: COG4425 698936005970 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 698936005971 methionine gamma-lyase; Validated; Region: PRK07049 698936005972 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698936005973 homodimer interface [polypeptide binding]; other site 698936005974 substrate-cofactor binding pocket; other site 698936005975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936005976 catalytic residue [active] 698936005977 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 698936005978 dimer interface [polypeptide binding]; other site 698936005979 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936005980 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936005981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936005982 enoyl-CoA hydratase; Provisional; Region: PRK05980 698936005983 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698936005984 substrate binding site [chemical binding]; other site 698936005985 oxyanion hole (OAH) forming residues; other site 698936005986 trimer interface [polypeptide binding]; other site 698936005987 Predicted integral membrane protein [Function unknown]; Region: COG5500 698936005988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 698936005989 Putative glucoamylase; Region: Glycoamylase; pfam10091 698936005990 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 698936005991 Uncharacterized conserved protein [Function unknown]; Region: COG1944 698936005992 YcaO-like family; Region: YcaO; pfam02624 698936005993 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 698936005994 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936005995 TPR motif; other site 698936005996 binding surface 698936005997 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 698936005998 Coenzyme A binding pocket [chemical binding]; other site 698936005999 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698936006000 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 698936006001 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 698936006002 active site 698936006003 substrate binding site [chemical binding]; other site 698936006004 FMN binding site [chemical binding]; other site 698936006005 putative catalytic residues [active] 698936006006 topology modulation protein; Reviewed; Region: PRK08118 698936006007 AAA domain; Region: AAA_17; pfam13207 698936006008 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 698936006009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936006010 motif II; other site 698936006011 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698936006012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936006013 Coenzyme A binding pocket [chemical binding]; other site 698936006014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 698936006015 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 698936006016 replicative DNA helicase; Provisional; Region: PRK05973 698936006017 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698936006018 dimer interface [polypeptide binding]; other site 698936006019 substrate binding site [chemical binding]; other site 698936006020 metal binding site [ion binding]; metal-binding site 698936006021 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 698936006022 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 698936006023 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 698936006024 Acid Phosphatase; Region: Acid_PPase; cl17256 698936006025 Uncharacterized conserved protein [Function unknown]; Region: COG2968 698936006026 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 698936006027 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 698936006028 Uncharacterized conserved protein [Function unknown]; Region: COG0432 698936006029 Uncharacterized conserved protein [Function unknown]; Region: COG5507 698936006030 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698936006031 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698936006032 catalytic residue [active] 698936006033 Uncharacterized conserved protein [Function unknown]; Region: COG4274 698936006034 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 698936006035 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 698936006036 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698936006037 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 698936006038 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698936006039 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698936006040 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936006041 DNA binding residues [nucleotide binding] 698936006042 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 698936006043 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698936006044 NAD(P) binding site [chemical binding]; other site 698936006045 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698936006046 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 698936006047 substrate-cofactor binding pocket; other site 698936006048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936006049 catalytic residue [active] 698936006050 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 698936006051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698936006052 ATP binding site [chemical binding]; other site 698936006053 putative Mg++ binding site [ion binding]; other site 698936006054 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698936006055 nucleotide binding region [chemical binding]; other site 698936006056 ATP-binding site [chemical binding]; other site 698936006057 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 698936006058 HRDC domain; Region: HRDC; pfam00570 698936006059 DNA primase; Validated; Region: dnaG; PRK05667 698936006060 CHC2 zinc finger; Region: zf-CHC2; cl17510 698936006061 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698936006062 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698936006063 active site 698936006064 metal binding site [ion binding]; metal-binding site 698936006065 interdomain interaction site; other site 698936006066 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 698936006067 Uncharacterized conserved protein [Function unknown]; Region: COG1610 698936006068 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698936006069 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 698936006070 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698936006071 catalytic site [active] 698936006072 subunit interface [polypeptide binding]; other site 698936006073 LysR family transcriptional regulator; Provisional; Region: PRK14997 698936006074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936006075 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698936006076 putative effector binding pocket; other site 698936006077 dimerization interface [polypeptide binding]; other site 698936006078 short chain dehydrogenase; Provisional; Region: PRK06500 698936006079 classical (c) SDRs; Region: SDR_c; cd05233 698936006080 NAD(P) binding site [chemical binding]; other site 698936006081 active site 698936006082 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 698936006083 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698936006084 aspartate aminotransferase; Provisional; Region: PRK05764 698936006085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936006086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936006087 homodimer interface [polypeptide binding]; other site 698936006088 catalytic residue [active] 698936006089 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698936006090 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 698936006091 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 698936006092 EamA-like transporter family; Region: EamA; pfam00892 698936006093 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698936006094 DNA-binding site [nucleotide binding]; DNA binding site 698936006095 RNA-binding motif; other site 698936006096 BA14K-like protein; Region: BA14K; pfam07886 698936006097 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698936006098 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 698936006099 Bacterial SH3 domain; Region: SH3_3; pfam08239 698936006100 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 698936006101 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698936006102 MarR family; Region: MarR_2; pfam12802 698936006103 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698936006104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936006105 active site 698936006106 phosphorylation site [posttranslational modification] 698936006107 intermolecular recognition site; other site 698936006108 dimerization interface [polypeptide binding]; other site 698936006109 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936006110 DNA binding site [nucleotide binding] 698936006111 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936006112 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698936006113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 698936006114 dimer interface [polypeptide binding]; other site 698936006115 phosphorylation site [posttranslational modification] 698936006116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936006117 ATP binding site [chemical binding]; other site 698936006118 Mg2+ binding site [ion binding]; other site 698936006119 G-X-G motif; other site 698936006120 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 698936006121 dimer interface [polypeptide binding]; other site 698936006122 putative tRNA-binding site [nucleotide binding]; other site 698936006123 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 698936006124 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698936006125 Uncharacterized conserved protein [Function unknown]; Region: COG5465 698936006126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 698936006127 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 698936006128 Uncharacterized conserved protein [Function unknown]; Region: COG1565 698936006129 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698936006130 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698936006131 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698936006132 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698936006133 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 698936006134 active site 698936006135 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 698936006136 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698936006137 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698936006138 active site 698936006139 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 698936006140 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 698936006141 tetramer interface [polypeptide binding]; other site 698936006142 active site 698936006143 Mg2+/Mn2+ binding site [ion binding]; other site 698936006144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 698936006145 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 698936006146 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698936006147 NAD(P) binding site [chemical binding]; other site 698936006148 catalytic residues [active] 698936006149 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 698936006150 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 698936006151 Benzoate membrane transport protein; Region: BenE; pfam03594 698936006152 benzoate transporter; Region: benE; TIGR00843 698936006153 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698936006154 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698936006155 5S rRNA interface [nucleotide binding]; other site 698936006156 CTC domain interface [polypeptide binding]; other site 698936006157 L16 interface [polypeptide binding]; other site 698936006158 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698936006159 putative active site [active] 698936006160 catalytic residue [active] 698936006161 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 698936006162 GTP-binding protein YchF; Reviewed; Region: PRK09601 698936006163 YchF GTPase; Region: YchF; cd01900 698936006164 G1 box; other site 698936006165 GTP/Mg2+ binding site [chemical binding]; other site 698936006166 Switch I region; other site 698936006167 G2 box; other site 698936006168 Switch II region; other site 698936006169 G3 box; other site 698936006170 G4 box; other site 698936006171 G5 box; other site 698936006172 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698936006173 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 698936006174 putative active site [active] 698936006175 putative catalytic site [active] 698936006176 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 698936006177 putative active site [active] 698936006178 putative catalytic site [active] 698936006179 Domain of unknown function (DUF1873); Region: DUF1873; pfam08969 698936006180 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698936006181 active site 698936006182 Predicted small metal-binding protein [Function unknown]; Region: COG5466 698936006183 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 698936006184 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698936006185 active site 698936006186 NTP binding site [chemical binding]; other site 698936006187 metal binding triad [ion binding]; metal-binding site 698936006188 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698936006189 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698936006190 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 698936006191 putative active site [active] 698936006192 putative CoA binding site [chemical binding]; other site 698936006193 nudix motif; other site 698936006194 metal binding site [ion binding]; metal-binding site 698936006195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 698936006196 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 698936006197 MoxR-like ATPases [General function prediction only]; Region: COG0714 698936006198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936006199 Walker A motif; other site 698936006200 ATP binding site [chemical binding]; other site 698936006201 Walker B motif; other site 698936006202 arginine finger; other site 698936006203 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 698936006204 Protein of unknown function DUF58; Region: DUF58; pfam01882 698936006205 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 698936006206 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 698936006207 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 698936006208 CARDB; Region: CARDB; pfam07705 698936006209 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 698936006210 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698936006211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936006212 Coenzyme A binding pocket [chemical binding]; other site 698936006213 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698936006214 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 698936006215 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698936006216 putative dimer interface [polypeptide binding]; other site 698936006217 N-terminal domain interface [polypeptide binding]; other site 698936006218 putative substrate binding pocket (H-site) [chemical binding]; other site 698936006219 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 698936006220 FIC domain binding interface [polypeptide binding]; other site 698936006221 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 698936006222 Fic/DOC family; Region: Fic; cl00960 698936006223 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 698936006224 nudix motif; other site 698936006225 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698936006226 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 698936006227 putative active site [active] 698936006228 putative metal binding site [ion binding]; other site 698936006229 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698936006230 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 698936006231 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698936006232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936006233 DNA binding residues [nucleotide binding] 698936006234 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 698936006235 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 698936006236 putative active site [active] 698936006237 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 698936006238 2-isopropylmalate synthase; Validated; Region: PRK03739 698936006239 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 698936006240 active site 698936006241 catalytic residues [active] 698936006242 metal binding site [ion binding]; metal-binding site 698936006243 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698936006244 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 698936006245 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698936006246 oligomer interface [polypeptide binding]; other site 698936006247 active site residues [active] 698936006248 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 698936006249 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698936006250 Cation efflux family; Region: Cation_efflux; cl00316 698936006251 anthranilate synthase; Provisional; Region: PRK13566 698936006252 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698936006253 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698936006254 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698936006255 glutamine binding [chemical binding]; other site 698936006256 catalytic triad [active] 698936006257 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 698936006258 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 698936006259 N-terminal plug; other site 698936006260 ligand-binding site [chemical binding]; other site 698936006261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 698936006262 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 698936006263 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698936006264 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698936006265 Potassium binding sites [ion binding]; other site 698936006266 Cesium cation binding sites [ion binding]; other site 698936006267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 698936006268 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 698936006269 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 698936006270 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698936006271 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 698936006272 putative active site [active] 698936006273 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 698936006274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 698936006275 thymidine kinase; Provisional; Region: PRK04296 698936006276 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698936006277 ATP binding site [chemical binding]; other site 698936006278 Walker A motif; other site 698936006279 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 698936006280 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 698936006281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936006282 dimer interface [polypeptide binding]; other site 698936006283 conserved gate region; other site 698936006284 putative PBP binding loops; other site 698936006285 ABC-ATPase subunit interface; other site 698936006286 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 698936006287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936006288 Walker A/P-loop; other site 698936006289 ATP binding site [chemical binding]; other site 698936006290 Q-loop/lid; other site 698936006291 ABC transporter signature motif; other site 698936006292 Walker B; other site 698936006293 D-loop; other site 698936006294 H-loop/switch region; other site 698936006295 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698936006296 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 698936006297 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 698936006298 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 698936006299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936006300 dimerization interface [polypeptide binding]; other site 698936006301 putative DNA binding site [nucleotide binding]; other site 698936006302 putative Zn2+ binding site [ion binding]; other site 698936006303 AAA domain; Region: AAA_33; pfam13671 698936006304 AAA domain; Region: AAA_17; pfam13207 698936006305 omega amino acid--pyruvate transaminase; Provisional; Region: PRK13360 698936006306 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698936006307 inhibitor-cofactor binding pocket; inhibition site 698936006308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936006309 catalytic residue [active] 698936006310 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 698936006311 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698936006312 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 698936006313 active site 698936006314 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 698936006315 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 698936006316 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698936006317 active site 698936006318 catalytic site [active] 698936006319 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698936006320 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 698936006321 substrate binding site [chemical binding]; other site 698936006322 ATP binding site [chemical binding]; other site 698936006323 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698936006324 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936006325 Walker A/P-loop; other site 698936006326 ATP binding site [chemical binding]; other site 698936006327 Q-loop/lid; other site 698936006328 ABC transporter signature motif; other site 698936006329 Walker B; other site 698936006330 D-loop; other site 698936006331 H-loop/switch region; other site 698936006332 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698936006333 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936006334 Walker A/P-loop; other site 698936006335 ATP binding site [chemical binding]; other site 698936006336 Q-loop/lid; other site 698936006337 ABC transporter signature motif; other site 698936006338 Walker B; other site 698936006339 D-loop; other site 698936006340 H-loop/switch region; other site 698936006341 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936006342 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698936006343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936006344 ABC-ATPase subunit interface; other site 698936006345 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936006346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936006347 dimer interface [polypeptide binding]; other site 698936006348 conserved gate region; other site 698936006349 putative PBP binding loops; other site 698936006350 ABC-ATPase subunit interface; other site 698936006351 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936006352 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 698936006353 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 698936006354 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 698936006355 active site 698936006356 dimer interface [polypeptide binding]; other site 698936006357 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 698936006358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936006359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936006360 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 698936006361 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698936006362 oligomeric interface; other site 698936006363 putative active site [active] 698936006364 homodimer interface [polypeptide binding]; other site 698936006365 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698936006366 apolar tunnel; other site 698936006367 heme binding site [chemical binding]; other site 698936006368 dimerization interface [polypeptide binding]; other site 698936006369 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 698936006370 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 698936006371 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698936006372 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 698936006373 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 698936006374 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 698936006375 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 698936006376 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 698936006377 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 698936006378 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 698936006379 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 698936006380 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 698936006381 putative hemin binding site; other site 698936006382 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698936006383 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698936006384 ABC-ATPase subunit interface; other site 698936006385 dimer interface [polypeptide binding]; other site 698936006386 putative PBP binding regions; other site 698936006387 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 698936006388 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698936006389 Walker A/P-loop; other site 698936006390 ATP binding site [chemical binding]; other site 698936006391 Q-loop/lid; other site 698936006392 ABC transporter signature motif; other site 698936006393 Walker B; other site 698936006394 D-loop; other site 698936006395 H-loop/switch region; other site 698936006396 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 698936006397 GAF domain; Region: GAF; pfam01590 698936006398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936006399 PAS fold; Region: PAS_3; pfam08447 698936006400 putative active site [active] 698936006401 heme pocket [chemical binding]; other site 698936006402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698936006403 HWE histidine kinase; Region: HWE_HK; pfam07536 698936006404 RNA polymerase sigma factor; Provisional; Region: PRK12516 698936006405 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698936006406 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936006407 DNA binding residues [nucleotide binding] 698936006408 two-component response regulator; Provisional; Region: PRK09191 698936006409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936006410 active site 698936006411 phosphorylation site [posttranslational modification] 698936006412 intermolecular recognition site; other site 698936006413 dimerization interface [polypeptide binding]; other site 698936006414 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 698936006415 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 698936006416 N- and C-terminal domain interface [polypeptide binding]; other site 698936006417 active site 698936006418 MgATP binding site [chemical binding]; other site 698936006419 catalytic site [active] 698936006420 metal binding site [ion binding]; metal-binding site 698936006421 carbohydrate binding site [chemical binding]; other site 698936006422 putative homodimer interface [polypeptide binding]; other site 698936006423 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 698936006424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936006425 motif II; other site 698936006426 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 698936006427 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 698936006428 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 698936006429 sorbitol dehydrogenase; Provisional; Region: PRK07067 698936006430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936006431 NAD(P) binding site [chemical binding]; other site 698936006432 active site 698936006433 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698936006434 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936006435 Walker A/P-loop; other site 698936006436 ATP binding site [chemical binding]; other site 698936006437 Q-loop/lid; other site 698936006438 ABC transporter signature motif; other site 698936006439 Walker B; other site 698936006440 D-loop; other site 698936006441 H-loop/switch region; other site 698936006442 TOBE domain; Region: TOBE_2; pfam08402 698936006443 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936006444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936006445 dimer interface [polypeptide binding]; other site 698936006446 conserved gate region; other site 698936006447 putative PBP binding loops; other site 698936006448 ABC-ATPase subunit interface; other site 698936006449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936006450 dimer interface [polypeptide binding]; other site 698936006451 conserved gate region; other site 698936006452 putative PBP binding loops; other site 698936006453 ABC-ATPase subunit interface; other site 698936006454 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936006455 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936006456 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698936006457 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698936006458 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 698936006459 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 698936006460 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 698936006461 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 698936006462 homodimer interface [polypeptide binding]; other site 698936006463 active site 698936006464 FMN binding site [chemical binding]; other site 698936006465 substrate binding site [chemical binding]; other site 698936006466 4Fe-4S binding domain; Region: Fer4_6; pfam12837 698936006467 4Fe-4S binding domain; Region: Fer4; pfam00037 698936006468 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 698936006469 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698936006470 putative NAD(P) binding site [chemical binding]; other site 698936006471 LysR family transcriptional regulator; Provisional; Region: PRK14997 698936006472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936006473 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 698936006474 putative effector binding pocket; other site 698936006475 putative dimerization interface [polypeptide binding]; other site 698936006476 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698936006477 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936006478 catalytic loop [active] 698936006479 iron binding site [ion binding]; other site 698936006480 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936006481 cyclase homology domain; Region: CHD; cd07302 698936006482 nucleotidyl binding site; other site 698936006483 metal binding site [ion binding]; metal-binding site 698936006484 dimer interface [polypeptide binding]; other site 698936006485 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 698936006486 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936006487 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 698936006488 allantoate amidohydrolase; Reviewed; Region: PRK12893 698936006489 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 698936006490 active site 698936006491 metal binding site [ion binding]; metal-binding site 698936006492 dimer interface [polypeptide binding]; other site 698936006493 phenylhydantoinase; Validated; Region: PRK08323 698936006494 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 698936006495 tetramer interface [polypeptide binding]; other site 698936006496 active site 698936006497 Predicted mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: COG4101 698936006498 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698936006499 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698936006500 Walker A/P-loop; other site 698936006501 ATP binding site [chemical binding]; other site 698936006502 Q-loop/lid; other site 698936006503 ABC transporter signature motif; other site 698936006504 Walker B; other site 698936006505 D-loop; other site 698936006506 H-loop/switch region; other site 698936006507 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698936006508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936006509 Coenzyme A binding pocket [chemical binding]; other site 698936006510 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698936006511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936006512 dimer interface [polypeptide binding]; other site 698936006513 conserved gate region; other site 698936006514 putative PBP binding loops; other site 698936006515 ABC-ATPase subunit interface; other site 698936006516 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698936006517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936006518 dimer interface [polypeptide binding]; other site 698936006519 conserved gate region; other site 698936006520 putative PBP binding loops; other site 698936006521 ABC-ATPase subunit interface; other site 698936006522 NMT1/THI5 like; Region: NMT1; pfam09084 698936006523 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698936006524 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936006525 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936006526 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698936006527 Protein export membrane protein; Region: SecD_SecF; cl14618 698936006528 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698936006529 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 698936006530 UreF; Region: UreF; pfam01730 698936006531 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 698936006532 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 698936006533 dimer interface [polypeptide binding]; other site 698936006534 catalytic residues [active] 698936006535 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698936006536 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698936006537 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 698936006538 catalytic triad [active] 698936006539 dimer interface [polypeptide binding]; other site 698936006540 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 698936006541 Predicted transcriptional regulator [Transcription]; Region: COG2944 698936006542 urease subunit alpha; Reviewed; Region: ureC; PRK13207 698936006543 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 698936006544 subunit interactions [polypeptide binding]; other site 698936006545 active site 698936006546 flap region; other site 698936006547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 698936006548 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 698936006549 alpha-beta subunit interface [polypeptide binding]; other site 698936006550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 698936006551 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 698936006552 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 698936006553 alpha-gamma subunit interface [polypeptide binding]; other site 698936006554 beta-gamma subunit interface [polypeptide binding]; other site 698936006555 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 698936006556 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 698936006557 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 698936006558 dimerization interface [polypeptide binding]; other site 698936006559 ligand binding site [chemical binding]; other site 698936006560 NADP binding site [chemical binding]; other site 698936006561 catalytic site [active] 698936006562 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698936006563 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936006564 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698936006565 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698936006566 MarR family; Region: MarR; pfam01047 698936006567 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 698936006568 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 698936006569 dimerization interface [polypeptide binding]; other site 698936006570 ligand binding site [chemical binding]; other site 698936006571 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 698936006572 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 698936006573 Walker A/P-loop; other site 698936006574 ATP binding site [chemical binding]; other site 698936006575 Q-loop/lid; other site 698936006576 ABC transporter signature motif; other site 698936006577 Walker B; other site 698936006578 D-loop; other site 698936006579 H-loop/switch region; other site 698936006580 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698936006581 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 698936006582 Walker A/P-loop; other site 698936006583 ATP binding site [chemical binding]; other site 698936006584 Q-loop/lid; other site 698936006585 ABC transporter signature motif; other site 698936006586 Walker B; other site 698936006587 D-loop; other site 698936006588 H-loop/switch region; other site 698936006589 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 698936006590 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 698936006591 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 698936006592 TM-ABC transporter signature motif; other site 698936006593 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936006594 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 698936006595 TM-ABC transporter signature motif; other site 698936006596 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698936006597 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698936006598 active site 698936006599 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698936006600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 698936006601 active site 698936006602 phosphorylation site [posttranslational modification] 698936006603 intermolecular recognition site; other site 698936006604 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698936006605 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698936006606 ligand binding site [chemical binding]; other site 698936006607 flexible hinge region; other site 698936006608 putative switch regulator; other site 698936006609 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 698936006610 non-specific DNA interactions [nucleotide binding]; other site 698936006611 DNA binding site [nucleotide binding] 698936006612 sequence specific DNA binding site [nucleotide binding]; other site 698936006613 putative cAMP binding site [chemical binding]; other site 698936006614 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 698936006615 classical (c) SDRs; Region: SDR_c; cd05233 698936006616 NAD(P) binding site [chemical binding]; other site 698936006617 active site 698936006618 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 698936006619 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936006620 Zn binding site [ion binding]; other site 698936006621 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 698936006622 Zn binding site [ion binding]; other site 698936006623 Predicted esterase [General function prediction only]; Region: COG0400 698936006624 putative hydrolase; Provisional; Region: PRK11460 698936006625 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 698936006626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 698936006627 Helix-turn-helix domain; Region: HTH_28; pfam13518 698936006628 Homeodomain-like domain; Region: HTH_32; pfam13565 698936006629 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698936006630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698936006631 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698936006632 Predicted flavoprotein [General function prediction only]; Region: COG0431 698936006633 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 698936006634 Zn binding site [ion binding]; other site 698936006635 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 698936006636 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936006637 Zn binding site [ion binding]; other site 698936006638 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698936006639 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 698936006640 putative active site [active] 698936006641 catalytic triad [active] 698936006642 putative dimer interface [polypeptide binding]; other site 698936006643 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936006644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936006645 dimer interface [polypeptide binding]; other site 698936006646 conserved gate region; other site 698936006647 putative PBP binding loops; other site 698936006648 ABC-ATPase subunit interface; other site 698936006649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936006650 putative PBP binding loops; other site 698936006651 ABC-ATPase subunit interface; other site 698936006652 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698936006653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936006654 Walker A/P-loop; other site 698936006655 ATP binding site [chemical binding]; other site 698936006656 Q-loop/lid; other site 698936006657 ABC transporter signature motif; other site 698936006658 Walker B; other site 698936006659 D-loop; other site 698936006660 H-loop/switch region; other site 698936006661 TOBE domain; Region: TOBE_2; pfam08402 698936006662 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698936006663 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698936006664 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 698936006665 agmatinase; Region: agmatinase; TIGR01230 698936006666 oligomer interface [polypeptide binding]; other site 698936006667 putative active site [active] 698936006668 Mn binding site [ion binding]; other site 698936006669 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698936006670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936006671 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 698936006672 dimerization interface [polypeptide binding]; other site 698936006673 substrate binding pocket [chemical binding]; other site 698936006674 hypothetical protein; Provisional; Region: PRK07550 698936006675 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936006676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936006677 homodimer interface [polypeptide binding]; other site 698936006678 catalytic residue [active] 698936006679 EamA-like transporter family; Region: EamA; pfam00892 698936006680 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 698936006681 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698936006682 NAD binding site [chemical binding]; other site 698936006683 catalytic residues [active] 698936006684 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698936006685 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936006686 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698936006687 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698936006688 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936006689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936006690 DNA-binding site [nucleotide binding]; DNA binding site 698936006691 FCD domain; Region: FCD; pfam07729 698936006692 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936006693 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936006694 DNA-binding site [nucleotide binding]; DNA binding site 698936006695 FCD domain; Region: FCD; pfam07729 698936006696 hypothetical protein; Provisional; Region: PRK05968 698936006697 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698936006698 homodimer interface [polypeptide binding]; other site 698936006699 substrate-cofactor binding pocket; other site 698936006700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936006701 catalytic residue [active] 698936006702 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936006703 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936006704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936006705 dimer interface [polypeptide binding]; other site 698936006706 conserved gate region; other site 698936006707 putative PBP binding loops; other site 698936006708 ABC-ATPase subunit interface; other site 698936006709 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936006710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936006711 dimer interface [polypeptide binding]; other site 698936006712 conserved gate region; other site 698936006713 putative PBP binding loops; other site 698936006714 ABC-ATPase subunit interface; other site 698936006715 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936006716 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936006717 Walker A/P-loop; other site 698936006718 ATP binding site [chemical binding]; other site 698936006719 Q-loop/lid; other site 698936006720 ABC transporter signature motif; other site 698936006721 Walker B; other site 698936006722 D-loop; other site 698936006723 H-loop/switch region; other site 698936006724 TOBE domain; Region: TOBE_2; pfam08402 698936006725 Cytochrome c2 [Energy production and conversion]; Region: COG3474 698936006726 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 698936006727 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 698936006728 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698936006729 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698936006730 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 698936006731 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 698936006732 Subunit I/III interface [polypeptide binding]; other site 698936006733 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 698936006734 Subunit I/III interface [polypeptide binding]; other site 698936006735 Predicted small integral membrane protein [Function unknown]; Region: COG5605 698936006736 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936006737 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936006738 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 698936006739 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698936006740 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698936006741 active site 698936006742 metal binding site [ion binding]; metal-binding site 698936006743 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936006744 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 698936006745 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936006746 short chain dehydrogenase; Provisional; Region: PRK07060 698936006747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936006748 NAD(P) binding site [chemical binding]; other site 698936006749 active site 698936006750 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698936006751 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 698936006752 inhibitor binding site; inhibition site 698936006753 catalytic Zn binding site [ion binding]; other site 698936006754 structural Zn binding site [ion binding]; other site 698936006755 NADP binding site [chemical binding]; other site 698936006756 tetramer interface [polypeptide binding]; other site 698936006757 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 698936006758 [2Fe-2S] cluster binding site [ion binding]; other site 698936006759 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 698936006760 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936006761 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 698936006762 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 698936006763 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936006764 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936006765 TM-ABC transporter signature motif; other site 698936006766 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698936006767 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936006768 Walker A/P-loop; other site 698936006769 ATP binding site [chemical binding]; other site 698936006770 Q-loop/lid; other site 698936006771 ABC transporter signature motif; other site 698936006772 Walker B; other site 698936006773 D-loop; other site 698936006774 H-loop/switch region; other site 698936006775 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 698936006776 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698936006777 putative ligand binding site [chemical binding]; other site 698936006778 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936006779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936006780 DNA binding site [nucleotide binding] 698936006781 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 698936006782 putative ligand binding site [chemical binding]; other site 698936006783 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698936006784 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 698936006785 putative metal binding site [ion binding]; other site 698936006786 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936006787 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 698936006788 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 698936006789 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 698936006790 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698936006791 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936006792 Walker A/P-loop; other site 698936006793 ATP binding site [chemical binding]; other site 698936006794 Q-loop/lid; other site 698936006795 ABC transporter signature motif; other site 698936006796 Walker B; other site 698936006797 D-loop; other site 698936006798 H-loop/switch region; other site 698936006799 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936006800 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936006801 Walker A/P-loop; other site 698936006802 ATP binding site [chemical binding]; other site 698936006803 Q-loop/lid; other site 698936006804 ABC transporter signature motif; other site 698936006805 Walker B; other site 698936006806 D-loop; other site 698936006807 H-loop/switch region; other site 698936006808 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936006809 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698936006810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936006811 dimer interface [polypeptide binding]; other site 698936006812 conserved gate region; other site 698936006813 putative PBP binding loops; other site 698936006814 ABC-ATPase subunit interface; other site 698936006815 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936006816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698936006817 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936006818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936006819 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 698936006820 putative dimerization interface [polypeptide binding]; other site 698936006821 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936006822 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936006823 TM-ABC transporter signature motif; other site 698936006824 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936006825 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936006826 Walker A/P-loop; other site 698936006827 ATP binding site [chemical binding]; other site 698936006828 Q-loop/lid; other site 698936006829 ABC transporter signature motif; other site 698936006830 Walker B; other site 698936006831 D-loop; other site 698936006832 H-loop/switch region; other site 698936006833 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936006834 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936006835 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 698936006836 ligand binding site [chemical binding]; other site 698936006837 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 698936006838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936006839 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936006840 NAD(P) binding site [chemical binding]; other site 698936006841 active site 698936006842 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 698936006843 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936006844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936006845 DNA-binding site [nucleotide binding]; DNA binding site 698936006846 FCD domain; Region: FCD; pfam07729 698936006847 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936006848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936006849 NAD(P) binding site [chemical binding]; other site 698936006850 active site 698936006851 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 698936006852 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 698936006853 dimer interface [polypeptide binding]; other site 698936006854 active site 698936006855 metal binding site [ion binding]; metal-binding site 698936006856 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698936006857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936006858 NAD(P) binding site [chemical binding]; other site 698936006859 active site 698936006860 short chain dehydrogenase; Provisional; Region: PRK06841 698936006861 classical (c) SDRs; Region: SDR_c; cd05233 698936006862 NAD(P) binding site [chemical binding]; other site 698936006863 active site 698936006864 glucose-6-phosphate isomerase; Provisional; Region: PRK04190 698936006865 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 698936006866 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 698936006867 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 698936006868 active site 698936006869 intersubunit interface [polypeptide binding]; other site 698936006870 catalytic residue [active] 698936006871 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 698936006872 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 698936006873 NAD(P) binding pocket [chemical binding]; other site 698936006874 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 698936006875 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 698936006876 putative ligand binding site [chemical binding]; other site 698936006877 putative NAD binding site [chemical binding]; other site 698936006878 catalytic site [active] 698936006879 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 698936006880 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 698936006881 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 698936006882 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698936006883 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698936006884 putative active site [active] 698936006885 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698936006886 intersubunit interface [polypeptide binding]; other site 698936006887 active site 698936006888 catalytic residue [active] 698936006889 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698936006890 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 698936006891 N- and C-terminal domain interface [polypeptide binding]; other site 698936006892 active site 698936006893 MgATP binding site [chemical binding]; other site 698936006894 catalytic site [active] 698936006895 metal binding site [ion binding]; metal-binding site 698936006896 xylulose binding site [chemical binding]; other site 698936006897 putative homodimer interface [polypeptide binding]; other site 698936006898 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698936006899 D-xylulose kinases, subgroup 3; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_3; cd07811 698936006900 putative N- and C-terminal domain interface [polypeptide binding]; other site 698936006901 putative active site [active] 698936006902 putative MgATP binding site [chemical binding]; other site 698936006903 catalytic site [active] 698936006904 metal binding site [ion binding]; metal-binding site 698936006905 putative xylulose binding site [chemical binding]; other site 698936006906 putative homodimer interface [polypeptide binding]; other site 698936006907 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698936006908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936006909 NAD(P) binding site [chemical binding]; other site 698936006910 active site 698936006911 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936006912 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936006913 TM-ABC transporter signature motif; other site 698936006914 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936006915 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936006916 Walker A/P-loop; other site 698936006917 ATP binding site [chemical binding]; other site 698936006918 Q-loop/lid; other site 698936006919 ABC transporter signature motif; other site 698936006920 Walker B; other site 698936006921 D-loop; other site 698936006922 H-loop/switch region; other site 698936006923 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936006924 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936006925 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 698936006926 putative ligand binding site [chemical binding]; other site 698936006927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936006928 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936006929 NAD(P) binding site [chemical binding]; other site 698936006930 active site 698936006931 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698936006932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936006933 DNA-binding site [nucleotide binding]; DNA binding site 698936006934 UTRA domain; Region: UTRA; pfam07702 698936006935 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698936006936 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 698936006937 N- and C-terminal domain interface [polypeptide binding]; other site 698936006938 active site 698936006939 MgATP binding site [chemical binding]; other site 698936006940 catalytic site [active] 698936006941 metal binding site [ion binding]; metal-binding site 698936006942 xylulose binding site [chemical binding]; other site 698936006943 homodimer interface [polypeptide binding]; other site 698936006944 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698936006945 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698936006946 TPP-binding site [chemical binding]; other site 698936006947 dimer interface [polypeptide binding]; other site 698936006948 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698936006949 PYR/PP interface [polypeptide binding]; other site 698936006950 dimer interface [polypeptide binding]; other site 698936006951 TPP binding site [chemical binding]; other site 698936006952 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698936006953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936006954 putative transporter; Provisional; Region: PRK10504 698936006955 putative substrate translocation pore; other site 698936006956 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 698936006957 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936006958 membrane-bound complex binding site; other site 698936006959 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698936006960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936006961 dimer interface [polypeptide binding]; other site 698936006962 conserved gate region; other site 698936006963 putative PBP binding loops; other site 698936006964 ABC-ATPase subunit interface; other site 698936006965 Ferredoxin [Energy production and conversion]; Region: COG1146 698936006966 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 698936006967 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 698936006968 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698936006969 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 698936006970 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698936006971 putative catalytic residue [active] 698936006972 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698936006973 apolar tunnel; other site 698936006974 heme binding site [chemical binding]; other site 698936006975 dimerization interface [polypeptide binding]; other site 698936006976 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698936006977 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698936006978 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698936006979 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698936006980 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698936006981 putative active site [active] 698936006982 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 698936006983 Isochorismatase family; Region: Isochorismatase; pfam00857 698936006984 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 698936006985 catalytic triad [active] 698936006986 conserved cis-peptide bond; other site 698936006987 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 698936006988 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698936006989 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698936006990 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 698936006991 Walker A/P-loop; other site 698936006992 ATP binding site [chemical binding]; other site 698936006993 Q-loop/lid; other site 698936006994 ABC transporter signature motif; other site 698936006995 Walker B; other site 698936006996 D-loop; other site 698936006997 H-loop/switch region; other site 698936006998 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 698936006999 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 698936007000 Walker A/P-loop; other site 698936007001 ATP binding site [chemical binding]; other site 698936007002 Q-loop/lid; other site 698936007003 ABC transporter signature motif; other site 698936007004 Walker B; other site 698936007005 D-loop; other site 698936007006 H-loop/switch region; other site 698936007007 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 698936007008 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936007009 TM-ABC transporter signature motif; other site 698936007010 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 698936007011 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 698936007012 TM-ABC transporter signature motif; other site 698936007013 Isochorismatase family; Region: Isochorismatase; pfam00857 698936007014 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 698936007015 catalytic triad [active] 698936007016 conserved cis-peptide bond; other site 698936007017 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 698936007018 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698936007019 inhibitor-cofactor binding pocket; inhibition site 698936007020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936007021 catalytic residue [active] 698936007022 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 698936007023 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698936007024 active site 698936007025 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 698936007026 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936007027 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 698936007028 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698936007029 active site 698936007030 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936007031 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 698936007032 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936007033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936007034 dimer interface [polypeptide binding]; other site 698936007035 conserved gate region; other site 698936007036 putative PBP binding loops; other site 698936007037 ABC-ATPase subunit interface; other site 698936007038 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698936007039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936007040 dimer interface [polypeptide binding]; other site 698936007041 conserved gate region; other site 698936007042 putative PBP binding loops; other site 698936007043 ABC-ATPase subunit interface; other site 698936007044 cytosine deaminase; Provisional; Region: PRK05985 698936007045 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 698936007046 active site 698936007047 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 698936007048 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698936007049 active site 698936007050 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698936007051 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936007052 Walker A/P-loop; other site 698936007053 ATP binding site [chemical binding]; other site 698936007054 Q-loop/lid; other site 698936007055 ABC transporter signature motif; other site 698936007056 Walker B; other site 698936007057 D-loop; other site 698936007058 H-loop/switch region; other site 698936007059 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936007060 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 698936007061 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936007062 Walker A/P-loop; other site 698936007063 ATP binding site [chemical binding]; other site 698936007064 Q-loop/lid; other site 698936007065 ABC transporter signature motif; other site 698936007066 Walker B; other site 698936007067 D-loop; other site 698936007068 H-loop/switch region; other site 698936007069 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 698936007070 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 698936007071 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936007072 DNA-binding site [nucleotide binding]; DNA binding site 698936007073 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698936007074 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 698936007075 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 698936007076 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936007077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698936007078 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698936007079 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 698936007080 [2Fe-2S] cluster binding site [ion binding]; other site 698936007081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936007082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936007083 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698936007084 putative effector binding pocket; other site 698936007085 putative dimerization interface [polypeptide binding]; other site 698936007086 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 698936007087 Transposase domain (DUF772); Region: DUF772; pfam05598 698936007088 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 698936007089 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 698936007090 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698936007091 Peptidase family M23; Region: Peptidase_M23; pfam01551 698936007092 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698936007093 Clp amino terminal domain; Region: Clp_N; pfam02861 698936007094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936007095 Walker A motif; other site 698936007096 ATP binding site [chemical binding]; other site 698936007097 Walker B motif; other site 698936007098 arginine finger; other site 698936007099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936007100 Walker A motif; other site 698936007101 ATP binding site [chemical binding]; other site 698936007102 Walker B motif; other site 698936007103 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698936007104 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 698936007105 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 698936007106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936007107 S-adenosylmethionine binding site [chemical binding]; other site 698936007108 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 698936007109 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698936007110 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698936007111 RF-1 domain; Region: RF-1; pfam00472 698936007112 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 698936007113 GAF domain; Region: GAF; pfam01590 698936007114 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698936007115 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698936007116 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698936007117 aspartate kinase; Reviewed; Region: PRK06635 698936007118 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698936007119 putative nucleotide binding site [chemical binding]; other site 698936007120 putative catalytic residues [active] 698936007121 putative Mg ion binding site [ion binding]; other site 698936007122 putative aspartate binding site [chemical binding]; other site 698936007123 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698936007124 putative allosteric regulatory site; other site 698936007125 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 698936007126 RibD C-terminal domain; Region: RibD_C; cl17279 698936007127 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698936007128 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 698936007129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936007130 S-adenosylmethionine binding site [chemical binding]; other site 698936007131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 698936007132 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698936007133 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 698936007134 putative active site [active] 698936007135 catalytic triad [active] 698936007136 dimer interface [polypeptide binding]; other site 698936007137 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 698936007138 GSH binding site [chemical binding]; other site 698936007139 catalytic residues [active] 698936007140 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 698936007141 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 698936007142 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 698936007143 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 698936007144 active site 698936007145 8-oxo-dGMP binding site [chemical binding]; other site 698936007146 nudix motif; other site 698936007147 metal binding site [ion binding]; metal-binding site 698936007148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936007149 Coenzyme A binding pocket [chemical binding]; other site 698936007150 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698936007151 heterotetramer interface [polypeptide binding]; other site 698936007152 active site pocket [active] 698936007153 cleavage site 698936007154 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 698936007155 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698936007156 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 698936007157 SEC-C motif; Region: SEC-C; pfam02810 698936007158 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698936007159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936007160 putative substrate translocation pore; other site 698936007161 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 698936007162 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 698936007163 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 698936007164 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 698936007165 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 698936007166 active site 698936007167 acyl-activating enzyme (AAE) consensus motif; other site 698936007168 putative CoA binding site [chemical binding]; other site 698936007169 AMP binding site [chemical binding]; other site 698936007170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 698936007171 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 698936007172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936007173 Coenzyme A binding pocket [chemical binding]; other site 698936007174 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 698936007175 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 698936007176 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698936007177 active site 698936007178 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 698936007179 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698936007180 minor groove reading motif; other site 698936007181 helix-hairpin-helix signature motif; other site 698936007182 substrate binding pocket [chemical binding]; other site 698936007183 active site 698936007184 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 698936007185 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 698936007186 active site 698936007187 HIGH motif; other site 698936007188 nucleotide binding site [chemical binding]; other site 698936007189 active site 698936007190 KMSKS motif; other site 698936007191 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 698936007192 short chain dehydrogenase; Provisional; Region: PRK05993 698936007193 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 698936007194 NADP binding site [chemical binding]; other site 698936007195 active site 698936007196 steroid binding site; other site 698936007197 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 698936007198 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 698936007199 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 698936007200 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698936007201 Ligand binding site [chemical binding]; other site 698936007202 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698936007203 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698936007204 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698936007205 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698936007206 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 698936007207 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 698936007208 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 698936007209 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698936007210 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698936007211 catalytic residues [active] 698936007212 argininosuccinate lyase; Provisional; Region: PRK00855 698936007213 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698936007214 active sites [active] 698936007215 tetramer interface [polypeptide binding]; other site 698936007216 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 698936007217 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 698936007218 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698936007219 active site 698936007220 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698936007221 substrate binding site [chemical binding]; other site 698936007222 catalytic residues [active] 698936007223 dimer interface [polypeptide binding]; other site 698936007224 TIGR02302 family protein; Region: aProt_lowcomp 698936007225 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 698936007226 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 698936007227 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698936007228 Response regulator receiver domain; Region: Response_reg; pfam00072 698936007229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936007230 active site 698936007231 phosphorylation site [posttranslational modification] 698936007232 intermolecular recognition site; other site 698936007233 dimerization interface [polypeptide binding]; other site 698936007234 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698936007235 active site 698936007236 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698936007237 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698936007238 Walker A/P-loop; other site 698936007239 ATP binding site [chemical binding]; other site 698936007240 Q-loop/lid; other site 698936007241 ABC transporter signature motif; other site 698936007242 Walker B; other site 698936007243 D-loop; other site 698936007244 H-loop/switch region; other site 698936007245 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698936007246 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698936007247 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698936007248 putative active site [active] 698936007249 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698936007250 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698936007251 putative acyl-acceptor binding pocket; other site 698936007252 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 698936007253 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 698936007254 putative active site pocket [active] 698936007255 dimerization interface [polypeptide binding]; other site 698936007256 putative catalytic residue [active] 698936007257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 698936007258 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 698936007259 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 698936007260 prephenate dehydrogenase; Validated; Region: PRK08507 698936007261 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 698936007262 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936007263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936007264 homodimer interface [polypeptide binding]; other site 698936007265 catalytic residue [active] 698936007266 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698936007267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936007268 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 698936007269 Uncharacterized conserved protein [Function unknown]; Region: COG3542 698936007270 aromatic amino acid exporter; Provisional; Region: PRK11689 698936007271 EamA-like transporter family; Region: EamA; pfam00892 698936007272 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 698936007273 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698936007274 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 698936007275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 698936007276 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 698936007277 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 698936007278 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 698936007279 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 698936007280 metal ion-dependent adhesion site (MIDAS); other site 698936007281 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 698936007282 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 698936007283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 698936007284 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 698936007285 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698936007286 HSP70 interaction site [polypeptide binding]; other site 698936007287 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 698936007288 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 698936007289 Domain of unknown function DUF21; Region: DUF21; pfam01595 698936007290 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698936007291 Transporter associated domain; Region: CorC_HlyC; smart01091 698936007292 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698936007293 active site 698936007294 dimer interface [polypeptide binding]; other site 698936007295 metal binding site [ion binding]; metal-binding site 698936007296 shikimate kinase; Provisional; Region: PRK13946 698936007297 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698936007298 ADP binding site [chemical binding]; other site 698936007299 magnesium binding site [ion binding]; other site 698936007300 putative shikimate binding site; other site 698936007301 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 698936007302 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 698936007303 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698936007304 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698936007305 active site 698936007306 DNA binding site [nucleotide binding] 698936007307 Int/Topo IB signature motif; other site 698936007308 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 698936007309 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 698936007310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 698936007311 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 698936007312 CPxP motif; other site 698936007313 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698936007314 oligomeric interface; other site 698936007315 putative active site [active] 698936007316 homodimer interface [polypeptide binding]; other site 698936007317 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 698936007318 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698936007319 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698936007320 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 698936007321 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 698936007322 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698936007323 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698936007324 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 698936007325 metal binding site [ion binding]; metal-binding site 698936007326 putative dimer interface [polypeptide binding]; other site 698936007327 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936007328 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936007329 putative DNA binding site [nucleotide binding]; other site 698936007330 putative Zn2+ binding site [ion binding]; other site 698936007331 AsnC family; Region: AsnC_trans_reg; pfam01037 698936007332 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698936007333 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 698936007334 putative NAD(P) binding site [chemical binding]; other site 698936007335 putative substrate binding site [chemical binding]; other site 698936007336 catalytic Zn binding site [ion binding]; other site 698936007337 structural Zn binding site [ion binding]; other site 698936007338 dimer interface [polypeptide binding]; other site 698936007339 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 698936007340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936007341 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936007342 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936007343 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 698936007344 putative DNA binding site [nucleotide binding]; other site 698936007345 putative Zn2+ binding site [ion binding]; other site 698936007346 AsnC family; Region: AsnC_trans_reg; pfam01037 698936007347 hypothetical protein; Provisional; Region: PRK06148 698936007348 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698936007349 active site 698936007350 ATP binding site [chemical binding]; other site 698936007351 Peptidase family M23; Region: Peptidase_M23; pfam01551 698936007352 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698936007353 inhibitor-cofactor binding pocket; inhibition site 698936007354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936007355 catalytic residue [active] 698936007356 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 698936007357 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936007358 substrate binding pocket [chemical binding]; other site 698936007359 membrane-bound complex binding site; other site 698936007360 hinge residues; other site 698936007361 hypothetical protein; Provisional; Region: PRK06149 698936007362 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698936007363 active site 698936007364 substrate binding site [chemical binding]; other site 698936007365 ATP binding site [chemical binding]; other site 698936007366 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698936007367 inhibitor-cofactor binding pocket; inhibition site 698936007368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936007369 catalytic residue [active] 698936007370 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 698936007371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936007372 DNA-binding site [nucleotide binding]; DNA binding site 698936007373 UTRA domain; Region: UTRA; pfam07702 698936007374 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 698936007375 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 698936007376 active site 698936007377 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 698936007378 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698936007379 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 698936007380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936007381 dimer interface [polypeptide binding]; other site 698936007382 conserved gate region; other site 698936007383 ABC-ATPase subunit interface; other site 698936007384 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698936007385 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 698936007386 Walker A/P-loop; other site 698936007387 ATP binding site [chemical binding]; other site 698936007388 Q-loop/lid; other site 698936007389 ABC transporter signature motif; other site 698936007390 Walker B; other site 698936007391 D-loop; other site 698936007392 H-loop/switch region; other site 698936007393 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 698936007394 active sites [active] 698936007395 tetramer interface [polypeptide binding]; other site 698936007396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 698936007397 Nucleoside recognition; Region: Gate; pfam07670 698936007398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 698936007399 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698936007400 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698936007401 Ligand Binding Site [chemical binding]; other site 698936007402 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698936007403 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936007404 DNA binding residues [nucleotide binding] 698936007405 dimerization interface [polypeptide binding]; other site 698936007406 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 698936007407 Predicted acetyltransferase [General function prediction only]; Region: COG2388 698936007408 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698936007409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936007410 active site 698936007411 phosphorylation site [posttranslational modification] 698936007412 intermolecular recognition site; other site 698936007413 dimerization interface [polypeptide binding]; other site 698936007414 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936007415 DNA binding site [nucleotide binding] 698936007416 Response regulator receiver domain; Region: Response_reg; pfam00072 698936007417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936007418 active site 698936007419 phosphorylation site [posttranslational modification] 698936007420 intermolecular recognition site; other site 698936007421 dimerization interface [polypeptide binding]; other site 698936007422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 698936007423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400 698936007424 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698936007425 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698936007426 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698936007427 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698936007428 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698936007429 RNA binding surface [nucleotide binding]; other site 698936007430 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698936007431 active site 698936007432 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 698936007433 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698936007434 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698936007435 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936007436 DNA binding residues [nucleotide binding] 698936007437 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698936007438 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698936007439 GDP-binding site [chemical binding]; other site 698936007440 ACT binding site; other site 698936007441 IMP binding site; other site 698936007442 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698936007443 EamA-like transporter family; Region: EamA; pfam00892 698936007444 EamA-like transporter family; Region: EamA; pfam00892 698936007445 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698936007446 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698936007447 ligand binding site [chemical binding]; other site 698936007448 NAD binding site [chemical binding]; other site 698936007449 dimerization interface [polypeptide binding]; other site 698936007450 catalytic site [active] 698936007451 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698936007452 putative L-serine binding site [chemical binding]; other site 698936007453 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 698936007454 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698936007455 catalytic residue [active] 698936007456 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 698936007457 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 698936007458 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 698936007459 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698936007460 active site 698936007461 substrate binding site [chemical binding]; other site 698936007462 metal binding site [ion binding]; metal-binding site 698936007463 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 698936007464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936007465 Walker A motif; other site 698936007466 ATP binding site [chemical binding]; other site 698936007467 Walker B motif; other site 698936007468 arginine finger; other site 698936007469 Peptidase family M41; Region: Peptidase_M41; pfam01434 698936007470 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698936007471 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698936007472 Ligand Binding Site [chemical binding]; other site 698936007473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936007474 binding surface 698936007475 Tetratricopeptide repeat; Region: TPR_16; pfam13432 698936007476 TPR motif; other site 698936007477 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 698936007478 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 698936007479 ligand binding site [chemical binding]; other site 698936007480 translocation protein TolB; Provisional; Region: tolB; PRK05137 698936007481 TolB amino-terminal domain; Region: TolB_N; pfam04052 698936007482 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 698936007483 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 698936007484 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 698936007485 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 698936007486 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 698936007487 TolR protein; Region: tolR; TIGR02801 698936007488 TolQ protein; Region: tolQ; TIGR02796 698936007489 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 698936007490 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 698936007491 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 698936007492 active site 698936007493 DNA binding site [nucleotide binding] 698936007494 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 698936007495 DNA binding site [nucleotide binding] 698936007496 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 698936007497 nucleotide binding site [chemical binding]; other site 698936007498 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698936007499 active site 698936007500 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 698936007501 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936007502 NAD binding site [chemical binding]; other site 698936007503 substrate binding site [chemical binding]; other site 698936007504 active site 698936007505 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 698936007506 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 698936007507 substrate binding site; other site 698936007508 Manganese binding site; other site 698936007509 dimer interface; other site 698936007510 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936007511 extended (e) SDRs; Region: SDR_e; cd08946 698936007512 NAD(P) binding site [chemical binding]; other site 698936007513 active site 698936007514 substrate binding site [chemical binding]; other site 698936007515 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698936007516 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698936007517 putative active site [active] 698936007518 putative metal binding site [ion binding]; other site 698936007519 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698936007520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936007521 Walker A motif; other site 698936007522 ATP binding site [chemical binding]; other site 698936007523 Walker B motif; other site 698936007524 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698936007525 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698936007526 RuvA N terminal domain; Region: RuvA_N; pfam01330 698936007527 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 698936007528 active site 698936007529 putative DNA-binding cleft [nucleotide binding]; other site 698936007530 dimer interface [polypeptide binding]; other site 698936007531 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698936007532 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 698936007533 hypothetical protein; Validated; Region: PRK00110 698936007534 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 698936007535 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 698936007536 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698936007537 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698936007538 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936007539 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936007540 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 698936007541 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698936007542 putative active site [active] 698936007543 metal binding site [ion binding]; metal-binding site 698936007544 homodimer binding site [polypeptide binding]; other site 698936007545 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 698936007546 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698936007547 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936007548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936007549 LysR substrate binding domain; Region: LysR_substrate; pfam03466 698936007550 dimerization interface [polypeptide binding]; other site 698936007551 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 698936007552 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 698936007553 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698936007554 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698936007555 TPP-binding site [chemical binding]; other site 698936007556 dimer interface [polypeptide binding]; other site 698936007557 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698936007558 PYR/PP interface [polypeptide binding]; other site 698936007559 dimer interface [polypeptide binding]; other site 698936007560 TPP binding site [chemical binding]; other site 698936007561 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698936007562 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 698936007563 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698936007564 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698936007565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 698936007566 Phosphoglycerate kinase; Region: PGK; pfam00162 698936007567 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698936007568 substrate binding site [chemical binding]; other site 698936007569 hinge regions; other site 698936007570 ADP binding site [chemical binding]; other site 698936007571 catalytic site [active] 698936007572 Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: COG3588 698936007573 catalytic residue [active] 698936007574 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698936007575 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936007576 cyclase homology domain; Region: CHD; cd07302 698936007577 nucleotidyl binding site; other site 698936007578 metal binding site [ion binding]; metal-binding site 698936007579 dimer interface [polypeptide binding]; other site 698936007580 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936007581 Tetratricopeptide repeat; Region: TPR_12; pfam13424 698936007582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936007583 TPR motif; other site 698936007584 TPR repeat; Region: TPR_11; pfam13414 698936007585 binding surface 698936007586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936007587 binding surface 698936007588 TPR motif; other site 698936007589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936007590 putative substrate translocation pore; other site 698936007591 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 698936007592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 698936007593 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 698936007594 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 698936007595 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936007596 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 698936007597 Walker A/P-loop; other site 698936007598 ATP binding site [chemical binding]; other site 698936007599 Q-loop/lid; other site 698936007600 ABC transporter signature motif; other site 698936007601 Walker B; other site 698936007602 D-loop; other site 698936007603 H-loop/switch region; other site 698936007604 hypothetical protein; Validated; Region: PRK09039 698936007605 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 698936007606 ligand binding site [chemical binding]; other site 698936007607 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698936007608 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698936007609 active site 698936007610 dimerization interface [polypeptide binding]; other site 698936007611 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 698936007612 Sel1-like repeats; Region: SEL1; smart00671 698936007613 Sel1-like repeats; Region: SEL1; smart00671 698936007614 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698936007615 thiamine phosphate binding site [chemical binding]; other site 698936007616 active site 698936007617 pyrophosphate binding site [ion binding]; other site 698936007618 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698936007619 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936007620 dimerization interface [polypeptide binding]; other site 698936007621 putative DNA binding site [nucleotide binding]; other site 698936007622 putative Zn2+ binding site [ion binding]; other site 698936007623 Uncharacterized small protein [Function unknown]; Region: COG5570 698936007624 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 698936007625 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698936007626 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698936007627 ATP-grasp domain; Region: ATP-grasp; pfam02222 698936007628 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 698936007629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936007630 TPR repeat; Region: TPR_11; pfam13414 698936007631 binding surface 698936007632 TPR motif; other site 698936007633 pyruvate kinase; Provisional; Region: PRK06247 698936007634 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 698936007635 domain interfaces; other site 698936007636 active site 698936007637 Predicted integral membrane protein [Function unknown]; Region: COG5480 698936007638 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 698936007639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 698936007640 hypothetical protein; Provisional; Region: PRK13694 698936007641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 698936007642 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 698936007643 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 698936007644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936007645 active site 698936007646 phosphorylation site [posttranslational modification] 698936007647 intermolecular recognition site; other site 698936007648 dimerization interface [polypeptide binding]; other site 698936007649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936007650 Walker A motif; other site 698936007651 ATP binding site [chemical binding]; other site 698936007652 Walker B motif; other site 698936007653 arginine finger; other site 698936007654 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 698936007655 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 698936007656 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 698936007657 active site 698936007658 Zn binding site [ion binding]; other site 698936007659 aminodeoxychorismate synthase; Provisional; Region: PRK07508 698936007660 chorismate binding enzyme; Region: Chorismate_bind; cl10555 698936007661 hypothetical protein; Provisional; Region: PRK07546 698936007662 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698936007663 substrate-cofactor binding pocket; other site 698936007664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936007665 catalytic residue [active] 698936007666 PAS fold; Region: PAS_7; pfam12860 698936007667 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936007668 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936007669 metal binding site [ion binding]; metal-binding site 698936007670 active site 698936007671 I-site; other site 698936007672 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 698936007673 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 698936007674 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 698936007675 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 698936007676 active site 698936007677 metal binding site [ion binding]; metal-binding site 698936007678 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 698936007679 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698936007680 ferrochelatase; Reviewed; Region: hemH; PRK00035 698936007681 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698936007682 C-terminal domain interface [polypeptide binding]; other site 698936007683 active site 698936007684 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698936007685 active site 698936007686 N-terminal domain interface [polypeptide binding]; other site 698936007687 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698936007688 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698936007689 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 698936007690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338 698936007691 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 698936007692 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698936007693 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698936007694 active site 698936007695 tetramer interface; other site 698936007696 Transglycosylase SLT domain; Region: SLT_2; pfam13406 698936007697 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698936007698 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698936007699 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698936007700 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 698936007701 active site 698936007702 catalytic triad [active] 698936007703 oxyanion hole [active] 698936007704 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 698936007705 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 698936007706 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 698936007707 active site 698936007708 dimer interface [polypeptide binding]; other site 698936007709 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 698936007710 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 698936007711 active site 698936007712 FMN binding site [chemical binding]; other site 698936007713 substrate binding site [chemical binding]; other site 698936007714 3Fe-4S cluster binding site [ion binding]; other site 698936007715 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 698936007716 domain interface; other site 698936007717 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 698936007718 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 698936007719 tetramer interface [polypeptide binding]; other site 698936007720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936007721 catalytic residue [active] 698936007722 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698936007723 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 698936007724 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 698936007725 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698936007726 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936007727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936007728 DNA binding residues [nucleotide binding] 698936007729 dimerization interface [polypeptide binding]; other site 698936007730 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 698936007731 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936007732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936007733 dimer interface [polypeptide binding]; other site 698936007734 conserved gate region; other site 698936007735 putative PBP binding loops; other site 698936007736 ABC-ATPase subunit interface; other site 698936007737 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698936007738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936007739 dimer interface [polypeptide binding]; other site 698936007740 conserved gate region; other site 698936007741 putative PBP binding loops; other site 698936007742 ABC-ATPase subunit interface; other site 698936007743 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698936007744 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936007745 Walker A/P-loop; other site 698936007746 ATP binding site [chemical binding]; other site 698936007747 Q-loop/lid; other site 698936007748 ABC transporter signature motif; other site 698936007749 Walker B; other site 698936007750 D-loop; other site 698936007751 H-loop/switch region; other site 698936007752 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936007753 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936007754 Walker A/P-loop; other site 698936007755 ATP binding site [chemical binding]; other site 698936007756 Q-loop/lid; other site 698936007757 ABC transporter signature motif; other site 698936007758 Walker B; other site 698936007759 D-loop; other site 698936007760 H-loop/switch region; other site 698936007761 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936007762 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698936007763 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936007764 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 698936007765 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 698936007766 putative dimer interface [polypeptide binding]; other site 698936007767 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698936007768 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936007769 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698936007770 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698936007771 active site 698936007772 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 698936007773 Response regulator receiver domain; Region: Response_reg; pfam00072 698936007774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936007775 active site 698936007776 phosphorylation site [posttranslational modification] 698936007777 intermolecular recognition site; other site 698936007778 dimerization interface [polypeptide binding]; other site 698936007779 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 698936007780 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698936007781 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 698936007782 pseudoazurin; Region: pseudoazurin; TIGR02375 698936007783 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698936007784 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698936007785 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 698936007786 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 698936007787 Moco binding site; other site 698936007788 metal coordination site [ion binding]; other site 698936007789 dimerization interface [polypeptide binding]; other site 698936007790 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 698936007791 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 698936007792 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698936007793 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936007794 DNA binding residues [nucleotide binding] 698936007795 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698936007796 MarR family; Region: MarR; pfam01047 698936007797 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 698936007798 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936007799 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698936007800 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936007801 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698936007802 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936007803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936007804 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936007805 dimerization interface [polypeptide binding]; other site 698936007806 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936007807 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936007808 active site 698936007809 catalytic tetrad [active] 698936007810 Uncharacterized conserved protein [Function unknown]; Region: COG2308 698936007811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 698936007812 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 698936007813 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 698936007814 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 698936007815 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 698936007816 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 698936007817 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698936007818 metal ion-dependent adhesion site (MIDAS); other site 698936007819 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 698936007820 homodimer interface [polypeptide binding]; other site 698936007821 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 698936007822 active site pocket [active] 698936007823 glycogen branching enzyme; Provisional; Region: PRK05402 698936007824 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 698936007825 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 698936007826 active site 698936007827 catalytic site [active] 698936007828 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 698936007829 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 698936007830 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 698936007831 ligand binding site; other site 698936007832 oligomer interface; other site 698936007833 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 698936007834 dimer interface [polypeptide binding]; other site 698936007835 N-terminal domain interface [polypeptide binding]; other site 698936007836 sulfate 1 binding site; other site 698936007837 glycogen synthase; Provisional; Region: glgA; PRK00654 698936007838 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 698936007839 ADP-binding pocket [chemical binding]; other site 698936007840 homodimer interface [polypeptide binding]; other site 698936007841 phosphoglucomutase; Region: PLN02307 698936007842 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 698936007843 substrate binding site [chemical binding]; other site 698936007844 dimer interface [polypeptide binding]; other site 698936007845 active site 698936007846 metal binding site [ion binding]; metal-binding site 698936007847 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698936007848 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698936007849 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698936007850 active site 698936007851 catalytic site [active] 698936007852 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 698936007853 putative active site [active] 698936007854 putative catalytic site [active] 698936007855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 698936007856 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 698936007857 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 698936007858 NAD binding site [chemical binding]; other site 698936007859 catalytic Zn binding site [ion binding]; other site 698936007860 substrate binding site [chemical binding]; other site 698936007861 structural Zn binding site [ion binding]; other site 698936007862 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 698936007863 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 698936007864 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 698936007865 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698936007866 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 698936007867 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 698936007868 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936007869 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 698936007870 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 698936007871 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 698936007872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936007873 TPR motif; other site 698936007874 binding surface 698936007875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936007876 binding surface 698936007877 TPR motif; other site 698936007878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936007879 binding surface 698936007880 TPR motif; other site 698936007881 Protein of unknown function (DUF992); Region: DUF992; pfam06186 698936007882 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936007883 cyclase homology domain; Region: CHD; cd07302 698936007884 nucleotidyl binding site; other site 698936007885 metal binding site [ion binding]; metal-binding site 698936007886 dimer interface [polypeptide binding]; other site 698936007887 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 698936007888 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 698936007889 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 698936007890 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 698936007891 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 698936007892 ligand binding site [chemical binding]; other site 698936007893 homodimer interface [polypeptide binding]; other site 698936007894 NAD(P) binding site [chemical binding]; other site 698936007895 trimer interface B [polypeptide binding]; other site 698936007896 trimer interface A [polypeptide binding]; other site 698936007897 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 698936007898 PAS domain; Region: PAS; smart00091 698936007899 PAS fold; Region: PAS_7; pfam12860 698936007900 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936007901 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936007902 metal binding site [ion binding]; metal-binding site 698936007903 active site 698936007904 I-site; other site 698936007905 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698936007906 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 698936007907 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 698936007908 catalytic triad [active] 698936007909 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 698936007910 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 698936007911 putative ligand binding site [chemical binding]; other site 698936007912 NAD binding site [chemical binding]; other site 698936007913 catalytic site [active] 698936007914 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936007915 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936007916 DNA binding site [nucleotide binding] 698936007917 domain linker motif; other site 698936007918 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 698936007919 putative dimerization interface [polypeptide binding]; other site 698936007920 putative ligand binding site [chemical binding]; other site 698936007921 MarR family; Region: MarR_2; cl17246 698936007922 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 698936007923 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698936007924 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 698936007925 P-loop, Walker A motif; other site 698936007926 Base recognition motif; other site 698936007927 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 698936007928 FOG: WD40 repeat [General function prediction only]; Region: COG2319 698936007929 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 698936007930 structural tetrad; other site 698936007931 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698936007932 Predicted acetyltransferase [General function prediction only]; Region: COG3153 698936007933 Coenzyme A binding pocket [chemical binding]; other site 698936007934 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 698936007935 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 698936007936 dimer interface [polypeptide binding]; other site 698936007937 active site 698936007938 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698936007939 catalytic residues [active] 698936007940 substrate binding site [chemical binding]; other site 698936007941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936007942 LysR family transcriptional regulator; Provisional; Region: PRK14997 698936007943 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698936007944 putative effector binding pocket; other site 698936007945 dimerization interface [polypeptide binding]; other site 698936007946 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 698936007947 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 698936007948 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 698936007949 putative active site [active] 698936007950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 698936007951 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698936007952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698936007953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 698936007954 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 698936007955 putative metal binding site [ion binding]; other site 698936007956 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 698936007957 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 698936007958 active site 698936007959 intersubunit interface [polypeptide binding]; other site 698936007960 catalytic residue [active] 698936007961 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 698936007962 putative active site [active] 698936007963 putative metal binding residues [ion binding]; other site 698936007964 signature motif; other site 698936007965 putative dimer interface [polypeptide binding]; other site 698936007966 putative phosphate binding site [ion binding]; other site 698936007967 CHAD domain; Region: CHAD; pfam05235 698936007968 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 698936007969 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698936007970 active site residue [active] 698936007971 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698936007972 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698936007973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936007974 dimer interface [polypeptide binding]; other site 698936007975 conserved gate region; other site 698936007976 ABC-ATPase subunit interface; other site 698936007977 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 698936007978 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698936007979 Walker A/P-loop; other site 698936007980 ATP binding site [chemical binding]; other site 698936007981 Q-loop/lid; other site 698936007982 ABC transporter signature motif; other site 698936007983 Walker B; other site 698936007984 D-loop; other site 698936007985 H-loop/switch region; other site 698936007986 NIL domain; Region: NIL; pfam09383 698936007987 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 698936007988 beta-galactosidase; Region: BGL; TIGR03356 698936007989 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936007990 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936007991 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936007992 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936007993 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 698936007994 xylose isomerase; Provisional; Region: PRK05474 698936007995 xylose isomerase; Region: xylose_isom_A; TIGR02630 698936007996 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 698936007997 N- and C-terminal domain interface [polypeptide binding]; other site 698936007998 D-xylulose kinase; Region: XylB; TIGR01312 698936007999 active site 698936008000 MgATP binding site [chemical binding]; other site 698936008001 catalytic site [active] 698936008002 metal binding site [ion binding]; metal-binding site 698936008003 xylulose binding site [chemical binding]; other site 698936008004 homodimer interface [polypeptide binding]; other site 698936008005 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936008006 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936008007 DNA binding site [nucleotide binding] 698936008008 domain linker motif; other site 698936008009 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 698936008010 putative ligand binding site [chemical binding]; other site 698936008011 Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion]; Region: COG5555 698936008012 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698936008013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936008014 putative substrate translocation pore; other site 698936008015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936008016 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 698936008017 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936008018 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936008019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936008020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936008021 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 698936008022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936008023 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936008024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936008025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 698936008026 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 698936008027 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698936008028 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698936008029 HIGH motif; other site 698936008030 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698936008031 active site 698936008032 KMSKS motif; other site 698936008033 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698936008034 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698936008035 dimer interface [polypeptide binding]; other site 698936008036 putative anticodon binding site; other site 698936008037 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 698936008038 motif 1; other site 698936008039 active site 698936008040 motif 2; other site 698936008041 motif 3; other site 698936008042 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 698936008043 active site 698936008044 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 698936008045 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698936008046 ATP-dependent DNA ligase; Validated; Region: PRK09247 698936008047 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 698936008048 active site 698936008049 DNA binding site [nucleotide binding] 698936008050 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 698936008051 DNA binding site [nucleotide binding] 698936008052 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3452 698936008053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936008054 PAS fold; Region: PAS_3; pfam08447 698936008055 putative active site [active] 698936008056 heme pocket [chemical binding]; other site 698936008057 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936008058 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936008059 metal binding site [ion binding]; metal-binding site 698936008060 active site 698936008061 I-site; other site 698936008062 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698936008063 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 698936008064 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 698936008065 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698936008066 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698936008067 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698936008068 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 698936008069 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 698936008070 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 698936008071 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698936008072 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 698936008073 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 698936008074 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 698936008075 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 698936008076 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698936008077 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936008078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936008079 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698936008080 putative effector binding pocket; other site 698936008081 dimerization interface [polypeptide binding]; other site 698936008082 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 698936008083 active site 698936008084 SAM binding site [chemical binding]; other site 698936008085 homodimer interface [polypeptide binding]; other site 698936008086 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 698936008087 active site 698936008088 putative homodimer interface [polypeptide binding]; other site 698936008089 SAM binding site [chemical binding]; other site 698936008090 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 698936008091 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 698936008092 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 698936008093 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 698936008094 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 698936008095 active site 698936008096 SAM binding site [chemical binding]; other site 698936008097 homodimer interface [polypeptide binding]; other site 698936008098 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 698936008099 active site 698936008100 SAM binding site [chemical binding]; other site 698936008101 homodimer interface [polypeptide binding]; other site 698936008102 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 698936008103 Precorrin-8X methylmutase; Region: CbiC; pfam02570 698936008104 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 698936008105 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698936008106 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 698936008107 active site 698936008108 SAM binding site [chemical binding]; other site 698936008109 homodimer interface [polypeptide binding]; other site 698936008110 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698936008111 ligand binding site [chemical binding]; other site 698936008112 active site 698936008113 UGI interface [polypeptide binding]; other site 698936008114 catalytic site [active] 698936008115 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 698936008116 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698936008117 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698936008118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936008119 dimer interface [polypeptide binding]; other site 698936008120 conserved gate region; other site 698936008121 putative PBP binding loops; other site 698936008122 ABC-ATPase subunit interface; other site 698936008123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936008124 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 698936008125 Walker A/P-loop; other site 698936008126 ATP binding site [chemical binding]; other site 698936008127 Q-loop/lid; other site 698936008128 ABC transporter signature motif; other site 698936008129 Walker B; other site 698936008130 D-loop; other site 698936008131 H-loop/switch region; other site 698936008132 TOBE domain; Region: TOBE; pfam03459 698936008133 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 698936008134 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698936008135 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936008136 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 698936008137 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 698936008138 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 698936008139 tetramer interface [polypeptide binding]; other site 698936008140 TPP-binding site [chemical binding]; other site 698936008141 heterodimer interface [polypeptide binding]; other site 698936008142 phosphorylation loop region [posttranslational modification] 698936008143 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 698936008144 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 698936008145 alpha subunit interface [polypeptide binding]; other site 698936008146 TPP binding site [chemical binding]; other site 698936008147 heterodimer interface [polypeptide binding]; other site 698936008148 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698936008149 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 698936008150 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698936008151 E3 interaction surface; other site 698936008152 lipoyl attachment site [posttranslational modification]; other site 698936008153 e3 binding domain; Region: E3_binding; pfam02817 698936008154 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698936008155 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 698936008156 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698936008157 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936008158 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698936008159 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 698936008160 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 698936008161 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 698936008162 putative active site [active] 698936008163 putative substrate binding site [chemical binding]; other site 698936008164 putative cosubstrate binding site; other site 698936008165 catalytic site [active] 698936008166 maleylacetoacetate isomerase; Region: maiA; TIGR01262 698936008167 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 698936008168 C-terminal domain interface [polypeptide binding]; other site 698936008169 GSH binding site (G-site) [chemical binding]; other site 698936008170 putative dimer interface [polypeptide binding]; other site 698936008171 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 698936008172 dimer interface [polypeptide binding]; other site 698936008173 N-terminal domain interface [polypeptide binding]; other site 698936008174 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 698936008175 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698936008176 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698936008177 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 698936008178 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698936008179 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 698936008180 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936008181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936008182 putative DNA binding site [nucleotide binding]; other site 698936008183 putative Zn2+ binding site [ion binding]; other site 698936008184 AsnC family; Region: AsnC_trans_reg; pfam01037 698936008185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 698936008186 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 698936008187 dimer interface [polypeptide binding]; other site 698936008188 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 698936008189 active site 698936008190 Fe binding site [ion binding]; other site 698936008191 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936008192 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936008193 DNA binding residues [nucleotide binding] 698936008194 dimerization interface [polypeptide binding]; other site 698936008195 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 698936008196 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936008197 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 698936008198 Walker A/P-loop; other site 698936008199 ATP binding site [chemical binding]; other site 698936008200 Q-loop/lid; other site 698936008201 ABC transporter signature motif; other site 698936008202 Walker B; other site 698936008203 D-loop; other site 698936008204 H-loop/switch region; other site 698936008205 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 698936008206 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936008207 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936008208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936008209 TPR motif; other site 698936008210 binding surface 698936008211 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936008212 binding surface 698936008213 Tetratricopeptide repeat; Region: TPR_16; pfam13432 698936008214 TPR motif; other site 698936008215 Tetratricopeptide repeat; Region: TPR_16; pfam13432 698936008216 Methyltransferase domain; Region: Methyltransf_25; pfam13649 698936008217 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936008218 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936008219 metal binding site [ion binding]; metal-binding site 698936008220 active site 698936008221 I-site; other site 698936008222 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698936008223 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698936008224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936008225 DNA-binding site [nucleotide binding]; DNA binding site 698936008226 UTRA domain; Region: UTRA; pfam07702 698936008227 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 698936008228 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 698936008229 putative active site [active] 698936008230 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 698936008231 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698936008232 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 698936008233 substrate binding site [chemical binding]; other site 698936008234 ATP binding site [chemical binding]; other site 698936008235 Predicted nucleic-acid-binding protein, contains PIN domain [General function prediction only]; Region: COG5573 698936008236 putative active site [active] 698936008237 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 698936008238 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698936008239 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698936008240 Walker A/P-loop; other site 698936008241 ATP binding site [chemical binding]; other site 698936008242 Q-loop/lid; other site 698936008243 ABC transporter signature motif; other site 698936008244 Walker B; other site 698936008245 D-loop; other site 698936008246 H-loop/switch region; other site 698936008247 EamA-like transporter family; Region: EamA; pfam00892 698936008248 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936008249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936008250 dimer interface [polypeptide binding]; other site 698936008251 conserved gate region; other site 698936008252 putative PBP binding loops; other site 698936008253 ABC-ATPase subunit interface; other site 698936008254 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698936008255 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936008256 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698936008257 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936008258 substrate binding pocket [chemical binding]; other site 698936008259 membrane-bound complex binding site; other site 698936008260 hinge residues; other site 698936008261 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936008262 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 698936008263 AP (apurinic/apyrimidinic) site pocket; other site 698936008264 DNA interaction; other site 698936008265 Metal-binding active site; metal-binding site 698936008266 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698936008267 Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565 698936008268 active site 698936008269 catalytic site [active] 698936008270 metal binding site [ion binding]; metal-binding site 698936008271 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698936008272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698936008273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936008274 dimer interface [polypeptide binding]; other site 698936008275 conserved gate region; other site 698936008276 putative PBP binding loops; other site 698936008277 ABC-ATPase subunit interface; other site 698936008278 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936008279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936008280 dimer interface [polypeptide binding]; other site 698936008281 conserved gate region; other site 698936008282 putative PBP binding loops; other site 698936008283 ABC-ATPase subunit interface; other site 698936008284 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 698936008285 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936008286 Walker A/P-loop; other site 698936008287 ATP binding site [chemical binding]; other site 698936008288 Q-loop/lid; other site 698936008289 ABC transporter signature motif; other site 698936008290 Walker B; other site 698936008291 D-loop; other site 698936008292 H-loop/switch region; other site 698936008293 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 698936008294 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698936008295 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936008296 Walker A/P-loop; other site 698936008297 ATP binding site [chemical binding]; other site 698936008298 Q-loop/lid; other site 698936008299 ABC transporter signature motif; other site 698936008300 Walker B; other site 698936008301 D-loop; other site 698936008302 H-loop/switch region; other site 698936008303 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 698936008304 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936008305 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 698936008306 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698936008307 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936008308 DNA binding residues [nucleotide binding] 698936008309 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698936008310 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936008311 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936008312 LysR substrate binding domain; Region: LysR_substrate; pfam03466 698936008313 dimerization interface [polypeptide binding]; other site 698936008314 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 698936008315 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 698936008316 putative ligand binding site [chemical binding]; other site 698936008317 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698936008318 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 698936008319 Walker A/P-loop; other site 698936008320 ATP binding site [chemical binding]; other site 698936008321 Q-loop/lid; other site 698936008322 ABC transporter signature motif; other site 698936008323 Walker B; other site 698936008324 D-loop; other site 698936008325 H-loop/switch region; other site 698936008326 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 698936008327 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 698936008328 Walker A/P-loop; other site 698936008329 ATP binding site [chemical binding]; other site 698936008330 Q-loop/lid; other site 698936008331 ABC transporter signature motif; other site 698936008332 Walker B; other site 698936008333 D-loop; other site 698936008334 H-loop/switch region; other site 698936008335 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936008336 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 698936008337 TM-ABC transporter signature motif; other site 698936008338 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 698936008339 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 698936008340 TM-ABC transporter signature motif; other site 698936008341 choline dehydrogenase; Validated; Region: PRK02106 698936008342 lycopene cyclase; Region: lycopene_cycl; TIGR01789 698936008343 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698936008344 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698936008345 MULE transposase domain; Region: MULE; pfam10551 698936008346 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 698936008347 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 698936008348 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 698936008349 substrate binding pocket [chemical binding]; other site 698936008350 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 698936008351 B12 binding site [chemical binding]; other site 698936008352 cobalt ligand [ion binding]; other site 698936008353 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 698936008354 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 698936008355 dimerization interface [polypeptide binding]; other site 698936008356 putative active cleft [active] 698936008357 hypothetical protein; Provisional; Region: PRK02487 698936008358 fructokinase; Reviewed; Region: PRK09557 698936008359 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698936008360 nucleotide binding site [chemical binding]; other site 698936008361 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 698936008362 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 698936008363 Predicted periplasmic protein [General function prediction only]; Region: COG3895 698936008364 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 698936008365 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 698936008366 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 698936008367 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 698936008368 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 698936008369 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698936008370 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 698936008371 substrate-cofactor binding pocket; other site 698936008372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936008373 catalytic residue [active] 698936008374 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 698936008375 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 698936008376 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698936008377 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698936008378 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936008379 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 698936008380 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698936008381 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936008382 cyclase homology domain; Region: CHD; cd07302 698936008383 nucleotidyl binding site; other site 698936008384 metal binding site [ion binding]; metal-binding site 698936008385 dimer interface [polypeptide binding]; other site 698936008386 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936008387 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 698936008388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936008389 TPR motif; other site 698936008390 binding surface 698936008391 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698936008392 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 698936008393 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 698936008394 Surface antigen; Region: Bac_surface_Ag; pfam01103 698936008395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 698936008396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 698936008397 Family of unknown function (DUF490); Region: DUF490; pfam04357 698936008398 Family of unknown function (DUF490); Region: DUF490; pfam04357 698936008399 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 698936008400 Phosphotransferase enzyme family; Region: APH; pfam01636 698936008401 active site 698936008402 ATP binding site [chemical binding]; other site 698936008403 antibiotic binding site [chemical binding]; other site 698936008404 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 698936008405 putative dimer interface [polypeptide binding]; other site 698936008406 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936008407 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936008408 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 698936008409 AsnC family; Region: AsnC_trans_reg; pfam01037 698936008410 Arginase family; Region: Arginase; cd09989 698936008411 active site 698936008412 Mn binding site [ion binding]; other site 698936008413 oligomer interface [polypeptide binding]; other site 698936008414 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 698936008415 putative CheA interaction surface; other site 698936008416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936008417 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 698936008418 putative active site [active] 698936008419 heme pocket [chemical binding]; other site 698936008420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936008421 putative active site [active] 698936008422 heme pocket [chemical binding]; other site 698936008423 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698936008424 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698936008425 dimer interface [polypeptide binding]; other site 698936008426 putative CheW interface [polypeptide binding]; other site 698936008427 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 698936008428 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 698936008429 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 698936008430 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936008431 catalytic loop [active] 698936008432 iron binding site [ion binding]; other site 698936008433 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 698936008434 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 698936008435 [4Fe-4S] binding site [ion binding]; other site 698936008436 molybdopterin cofactor binding site; other site 698936008437 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 698936008438 molybdopterin cofactor binding site; other site 698936008439 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 698936008440 putative dimer interface [polypeptide binding]; other site 698936008441 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 698936008442 SLBB domain; Region: SLBB; pfam10531 698936008443 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 698936008444 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 698936008445 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 698936008446 putative dimer interface [polypeptide binding]; other site 698936008447 [2Fe-2S] cluster binding site [ion binding]; other site 698936008448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936008449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936008450 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698936008451 dimerization interface [polypeptide binding]; other site 698936008452 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698936008453 classical (c) SDRs; Region: SDR_c; cd05233 698936008454 NAD(P) binding site [chemical binding]; other site 698936008455 active site 698936008456 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698936008457 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 698936008458 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698936008459 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 698936008460 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698936008461 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698936008462 Walker A/P-loop; other site 698936008463 ATP binding site [chemical binding]; other site 698936008464 Q-loop/lid; other site 698936008465 ABC transporter signature motif; other site 698936008466 Walker B; other site 698936008467 D-loop; other site 698936008468 H-loop/switch region; other site 698936008469 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698936008470 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698936008471 Walker A/P-loop; other site 698936008472 ATP binding site [chemical binding]; other site 698936008473 Q-loop/lid; other site 698936008474 ABC transporter signature motif; other site 698936008475 Walker B; other site 698936008476 D-loop; other site 698936008477 H-loop/switch region; other site 698936008478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936008479 dimer interface [polypeptide binding]; other site 698936008480 conserved gate region; other site 698936008481 putative PBP binding loops; other site 698936008482 ABC-ATPase subunit interface; other site 698936008483 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936008484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936008485 dimer interface [polypeptide binding]; other site 698936008486 conserved gate region; other site 698936008487 putative PBP binding loops; other site 698936008488 ABC-ATPase subunit interface; other site 698936008489 Predicted small integral membrane protein [Function unknown]; Region: COG5477 698936008490 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936008491 xanthine permease; Region: pbuX; TIGR03173 698936008492 xanthine permease; Region: pbuX; TIGR03173 698936008493 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 698936008494 EamA-like transporter family; Region: EamA; pfam00892 698936008495 EamA-like transporter family; Region: EamA; pfam00892 698936008496 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698936008497 metal binding site 2 [ion binding]; metal-binding site 698936008498 putative DNA binding helix; other site 698936008499 metal binding site 1 [ion binding]; metal-binding site 698936008500 dimer interface [polypeptide binding]; other site 698936008501 structural Zn2+ binding site [ion binding]; other site 698936008502 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 698936008503 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698936008504 metal binding site [ion binding]; metal-binding site 698936008505 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 698936008506 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698936008507 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698936008508 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698936008509 ABC-ATPase subunit interface; other site 698936008510 dimer interface [polypeptide binding]; other site 698936008511 putative PBP binding regions; other site 698936008512 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698936008513 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698936008514 ABC-ATPase subunit interface; other site 698936008515 dimer interface [polypeptide binding]; other site 698936008516 putative PBP binding regions; other site 698936008517 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936008518 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 698936008519 AsnC family; Region: AsnC_trans_reg; pfam01037 698936008520 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 698936008521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936008522 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698936008523 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698936008524 gamma subunit interface [polypeptide binding]; other site 698936008525 epsilon subunit interface [polypeptide binding]; other site 698936008526 LBP interface [polypeptide binding]; other site 698936008527 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698936008528 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698936008529 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698936008530 alpha subunit interaction interface [polypeptide binding]; other site 698936008531 Walker A motif; other site 698936008532 ATP binding site [chemical binding]; other site 698936008533 Walker B motif; other site 698936008534 inhibitor binding site; inhibition site 698936008535 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698936008536 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698936008537 core domain interface [polypeptide binding]; other site 698936008538 delta subunit interface [polypeptide binding]; other site 698936008539 epsilon subunit interface [polypeptide binding]; other site 698936008540 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698936008541 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698936008542 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698936008543 beta subunit interaction interface [polypeptide binding]; other site 698936008544 Walker A motif; other site 698936008545 ATP binding site [chemical binding]; other site 698936008546 Walker B motif; other site 698936008547 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698936008548 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 698936008549 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698936008550 primosome assembly protein PriA; Validated; Region: PRK05580 698936008551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698936008552 ATP binding site [chemical binding]; other site 698936008553 putative Mg++ binding site [ion binding]; other site 698936008554 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698936008555 nucleotide binding region [chemical binding]; other site 698936008556 ATP-binding site [chemical binding]; other site 698936008557 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 698936008558 active site 698936008559 intersubunit interactions; other site 698936008560 catalytic residue [active] 698936008561 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698936008562 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 698936008563 Tetratricopeptide repeat; Region: TPR_16; pfam13432 698936008564 Protein of unknown function (DUF560); Region: DUF560; pfam04575 698936008565 Predicted ATPase [General function prediction only]; Region: COG4637 698936008566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936008567 Walker A/P-loop; other site 698936008568 ATP binding site [chemical binding]; other site 698936008569 Putative hemolysin [General function prediction only]; Region: COG3176 698936008570 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698936008571 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 698936008572 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698936008573 active site 698936008574 DNA binding site [nucleotide binding] 698936008575 Int/Topo IB signature motif; other site 698936008576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 698936008577 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 698936008578 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698936008579 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936008580 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698936008581 short chain dehydrogenase; Provisional; Region: PRK06123 698936008582 classical (c) SDRs; Region: SDR_c; cd05233 698936008583 NAD(P) binding site [chemical binding]; other site 698936008584 active site 698936008585 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698936008586 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 698936008587 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698936008588 E3 interaction surface; other site 698936008589 lipoyl attachment site [posttranslational modification]; other site 698936008590 e3 binding domain; Region: E3_binding; pfam02817 698936008591 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698936008592 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 698936008593 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698936008594 TPP-binding site [chemical binding]; other site 698936008595 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 698936008596 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 698936008597 CoA binding domain; Region: CoA_binding; smart00881 698936008598 CoA-ligase; Region: Ligase_CoA; pfam00549 698936008599 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 698936008600 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 698936008601 CoA-ligase; Region: Ligase_CoA; pfam00549 698936008602 malate dehydrogenase; Reviewed; Region: PRK06223 698936008603 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 698936008604 NAD(P) binding site [chemical binding]; other site 698936008605 dimer interface [polypeptide binding]; other site 698936008606 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698936008607 substrate binding site [chemical binding]; other site 698936008608 Predicted ATPase [General function prediction only]; Region: COG1485 698936008609 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 698936008610 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936008611 non-specific DNA binding site [nucleotide binding]; other site 698936008612 salt bridge; other site 698936008613 sequence-specific DNA binding site [nucleotide binding]; other site 698936008614 Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549 698936008615 Protease inhibitor Inh; Region: Inh; pfam02974 698936008616 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936008617 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936008618 Walker A/P-loop; other site 698936008619 ATP binding site [chemical binding]; other site 698936008620 Q-loop/lid; other site 698936008621 ABC transporter signature motif; other site 698936008622 Walker B; other site 698936008623 D-loop; other site 698936008624 H-loop/switch region; other site 698936008625 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936008626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936008627 dimer interface [polypeptide binding]; other site 698936008628 conserved gate region; other site 698936008629 putative PBP binding loops; other site 698936008630 ABC-ATPase subunit interface; other site 698936008631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936008632 dimer interface [polypeptide binding]; other site 698936008633 conserved gate region; other site 698936008634 putative PBP binding loops; other site 698936008635 ABC-ATPase subunit interface; other site 698936008636 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936008637 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936008638 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 698936008639 putative Zn2+ binding site [ion binding]; other site 698936008640 putative DNA binding site [nucleotide binding]; other site 698936008641 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698936008642 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698936008643 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936008644 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936008645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828 698936008646 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 698936008647 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 698936008648 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698936008649 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 698936008650 L-aspartate oxidase; Provisional; Region: PRK06175 698936008651 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698936008652 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 698936008653 putative SdhC subunit interface [polypeptide binding]; other site 698936008654 putative proximal heme binding site [chemical binding]; other site 698936008655 putative Iron-sulfur protein interface [polypeptide binding]; other site 698936008656 putative proximal quinone binding site; other site 698936008657 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 698936008658 Iron-sulfur protein interface; other site 698936008659 proximal quinone binding site [chemical binding]; other site 698936008660 SdhD (CybS) interface [polypeptide binding]; other site 698936008661 proximal heme binding site [chemical binding]; other site 698936008662 Predicted methyltransferase [General function prediction only]; Region: COG3897 698936008663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698936008664 Uncharacterized conserved protein [Function unknown]; Region: COG2947 698936008665 YciI-like protein; Reviewed; Region: PRK12865 698936008666 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698936008667 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698936008668 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698936008669 UGMP family protein; Validated; Region: PRK09604 698936008670 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 698936008671 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698936008672 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 698936008673 domain interfaces; other site 698936008674 active site 698936008675 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 698936008676 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698936008677 active site 698936008678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 698936008679 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 698936008680 HemY protein N-terminus; Region: HemY_N; pfam07219 698936008681 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 698936008682 putative metal binding site [ion binding]; other site 698936008683 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698936008684 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698936008685 catalytic triad [active] 698936008686 enterobactin exporter EntS; Provisional; Region: PRK10489 698936008687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936008688 putative substrate translocation pore; other site 698936008689 YGGT family; Region: YGGT; pfam02325 698936008690 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698936008691 dimer interface [polypeptide binding]; other site 698936008692 substrate binding site [chemical binding]; other site 698936008693 metal binding sites [ion binding]; metal-binding site 698936008694 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698936008695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936008696 Coenzyme A binding pocket [chemical binding]; other site 698936008697 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698936008698 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 698936008699 G1 box; other site 698936008700 putative GEF interaction site [polypeptide binding]; other site 698936008701 GTP/Mg2+ binding site [chemical binding]; other site 698936008702 Switch I region; other site 698936008703 G2 box; other site 698936008704 G3 box; other site 698936008705 Switch II region; other site 698936008706 G4 box; other site 698936008707 G5 box; other site 698936008708 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698936008709 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698936008710 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 698936008711 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 698936008712 putative active site [active] 698936008713 putative metal binding site [ion binding]; other site 698936008714 KTSC domain; Region: KTSC; pfam13619 698936008715 amidase; Provisional; Region: PRK07056 698936008716 amidase; Validated; Region: PRK05962 698936008717 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 698936008718 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698936008719 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698936008720 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698936008721 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698936008722 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698936008723 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698936008724 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698936008725 GTPase CgtA; Reviewed; Region: obgE; PRK12299 698936008726 GTP1/OBG; Region: GTP1_OBG; pfam01018 698936008727 Obg GTPase; Region: Obg; cd01898 698936008728 G1 box; other site 698936008729 GTP/Mg2+ binding site [chemical binding]; other site 698936008730 Switch I region; other site 698936008731 G2 box; other site 698936008732 G3 box; other site 698936008733 Switch II region; other site 698936008734 G4 box; other site 698936008735 G5 box; other site 698936008736 gamma-glutamyl kinase; Provisional; Region: PRK05429 698936008737 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698936008738 nucleotide binding site [chemical binding]; other site 698936008739 homotetrameric interface [polypeptide binding]; other site 698936008740 putative phosphate binding site [ion binding]; other site 698936008741 putative allosteric binding site; other site 698936008742 PUA domain; Region: PUA; pfam01472 698936008743 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698936008744 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698936008745 putative catalytic cysteine [active] 698936008746 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 698936008747 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698936008748 active site 698936008749 (T/H)XGH motif; other site 698936008750 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 698936008751 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 698936008752 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 698936008753 Peptidase family M23; Region: Peptidase_M23; pfam01551 698936008754 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 698936008755 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 698936008756 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 698936008757 protein binding site [polypeptide binding]; other site 698936008758 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 698936008759 Catalytic dyad [active] 698936008760 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 698936008761 NodB motif; other site 698936008762 putative active site [active] 698936008763 putative catalytic site [active] 698936008764 Zn binding site [ion binding]; other site 698936008765 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 698936008766 putative active site [active] 698936008767 Ap4A binding site [chemical binding]; other site 698936008768 nudix motif; other site 698936008769 putative metal binding site [ion binding]; other site 698936008770 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 698936008771 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 698936008772 heme binding site [chemical binding]; other site 698936008773 ferroxidase pore; other site 698936008774 ferroxidase diiron center [ion binding]; other site 698936008775 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 698936008776 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698936008777 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 698936008778 putative active site [active] 698936008779 putative PHP Thumb interface [polypeptide binding]; other site 698936008780 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698936008781 generic binding surface II; other site 698936008782 generic binding surface I; other site 698936008783 DNA Polymerase Y-family; Region: PolY_like; cd03468 698936008784 active site 698936008785 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 698936008786 DNA binding site [nucleotide binding] 698936008787 Uncharacterized conserved protein [Function unknown]; Region: COG4544 698936008788 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 698936008789 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 698936008790 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 698936008791 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698936008792 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698936008793 substrate binding site [chemical binding]; other site 698936008794 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 698936008795 homotrimer interaction site [polypeptide binding]; other site 698936008796 putative active site [active] 698936008797 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 698936008798 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 698936008799 proposed active site lysine [active] 698936008800 conserved cys residue [active] 698936008801 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 698936008802 active site 698936008803 catalytic residues [active] 698936008804 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698936008805 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 698936008806 P-loop, Walker A motif; other site 698936008807 Base recognition motif; other site 698936008808 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 698936008809 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 698936008810 putative deacylase active site [active] 698936008811 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698936008812 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698936008813 catalytic residues [active] 698936008814 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 698936008815 Uncharacterized conserved protein [Function unknown]; Region: COG2835 698936008816 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 698936008817 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698936008818 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 698936008819 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 698936008820 active site 698936008821 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 698936008822 catalytic triad [active] 698936008823 dimer interface [polypeptide binding]; other site 698936008824 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698936008825 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698936008826 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 698936008827 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698936008828 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 698936008829 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698936008830 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698936008831 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 698936008832 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 698936008833 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698936008834 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936008835 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936008836 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936008837 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 698936008838 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698936008839 ligand binding site [chemical binding]; other site 698936008840 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936008841 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936008842 TM-ABC transporter signature motif; other site 698936008843 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698936008844 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936008845 Walker A/P-loop; other site 698936008846 ATP binding site [chemical binding]; other site 698936008847 Q-loop/lid; other site 698936008848 ABC transporter signature motif; other site 698936008849 Walker B; other site 698936008850 D-loop; other site 698936008851 H-loop/switch region; other site 698936008852 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698936008853 MarR family; Region: MarR_2; pfam12802 698936008854 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698936008855 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698936008856 nucleotide binding site [chemical binding]; other site 698936008857 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698936008858 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698936008859 nucleotide binding site [chemical binding]; other site 698936008860 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 698936008861 putative catalytic site [active] 698936008862 putative phosphate binding site [ion binding]; other site 698936008863 active site 698936008864 metal binding site A [ion binding]; metal-binding site 698936008865 DNA binding site [nucleotide binding] 698936008866 putative AP binding site [nucleotide binding]; other site 698936008867 putative metal binding site B [ion binding]; other site 698936008868 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698936008869 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698936008870 ligand binding site [chemical binding]; other site 698936008871 flexible hinge region; other site 698936008872 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698936008873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936008874 active site 698936008875 phosphorylation site [posttranslational modification] 698936008876 intermolecular recognition site; other site 698936008877 dimerization interface [polypeptide binding]; other site 698936008878 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936008879 DNA binding site [nucleotide binding] 698936008880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 698936008881 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698936008882 catalytic core [active] 698936008883 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698936008884 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698936008885 substrate binding site [chemical binding]; other site 698936008886 ligand binding site [chemical binding]; other site 698936008887 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698936008888 MarR family; Region: MarR_2; pfam12802 698936008889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936008890 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936008891 putative substrate translocation pore; other site 698936008892 argininosuccinate synthase; Provisional; Region: PRK13820 698936008893 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698936008894 ANP binding site [chemical binding]; other site 698936008895 Substrate Binding Site II [chemical binding]; other site 698936008896 Substrate Binding Site I [chemical binding]; other site 698936008897 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698936008898 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 698936008899 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936008900 Walker A/P-loop; other site 698936008901 ATP binding site [chemical binding]; other site 698936008902 Q-loop/lid; other site 698936008903 ABC transporter signature motif; other site 698936008904 Walker B; other site 698936008905 D-loop; other site 698936008906 H-loop/switch region; other site 698936008907 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936008908 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 698936008909 TM-ABC transporter signature motif; other site 698936008910 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 698936008911 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698936008912 zinc binding site [ion binding]; other site 698936008913 putative ligand binding site [chemical binding]; other site 698936008914 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 698936008915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698936008916 FeS/SAM binding site; other site 698936008917 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 698936008918 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 698936008919 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698936008920 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 698936008921 Transposase [DNA replication, recombination, and repair]; Region: COG5433 698936008922 Uncharacterized conserved protein [Function unknown]; Region: COG3339 698936008923 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 698936008924 aromatic arch; other site 698936008925 DCoH dimer interaction site [polypeptide binding]; other site 698936008926 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 698936008927 DCoH tetramer interaction site [polypeptide binding]; other site 698936008928 substrate binding site [chemical binding]; other site 698936008929 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 698936008930 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 698936008931 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 698936008932 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 698936008933 active site 698936008934 catalytic triad [active] 698936008935 oxyanion hole [active] 698936008936 switch loop; other site 698936008937 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 698936008938 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698936008939 Walker A/P-loop; other site 698936008940 ATP binding site [chemical binding]; other site 698936008941 Q-loop/lid; other site 698936008942 ABC transporter signature motif; other site 698936008943 Walker B; other site 698936008944 D-loop; other site 698936008945 H-loop/switch region; other site 698936008946 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 698936008947 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 698936008948 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 698936008949 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698936008950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936008951 Coenzyme A binding pocket [chemical binding]; other site 698936008952 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 698936008953 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698936008954 oligomer interface [polypeptide binding]; other site 698936008955 active site residues [active] 698936008956 Uncharacterized conserved protein [Function unknown]; Region: COG3832 698936008957 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936008958 dimerization interface [polypeptide binding]; other site 698936008959 putative DNA binding site [nucleotide binding]; other site 698936008960 putative Zn2+ binding site [ion binding]; other site 698936008961 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 698936008962 Uncharacterized secreted protein [Function unknown]; Region: COG5429 698936008963 aconitate hydratase; Validated; Region: PRK09277 698936008964 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 698936008965 substrate binding site [chemical binding]; other site 698936008966 ligand binding site [chemical binding]; other site 698936008967 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698936008968 substrate binding site [chemical binding]; other site 698936008969 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 698936008970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936008971 Walker A/P-loop; other site 698936008972 ATP binding site [chemical binding]; other site 698936008973 Q-loop/lid; other site 698936008974 ABC transporter signature motif; other site 698936008975 Walker B; other site 698936008976 D-loop; other site 698936008977 H-loop/switch region; other site 698936008978 heme exporter protein CcmB; Region: ccmB; TIGR01190 698936008979 heme exporter protein CcmC; Region: ccmC; TIGR01191 698936008980 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 698936008981 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 698936008982 catalytic residues [active] 698936008983 central insert; other site 698936008984 hypothetical protein; Provisional; Region: PRK00944 698936008985 intracellular septation protein A; Reviewed; Region: PRK00259 698936008986 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698936008987 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698936008988 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698936008989 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 698936008990 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698936008991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698936008992 FeS/SAM binding site; other site 698936008993 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 698936008994 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698936008995 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698936008996 signal recognition particle protein; Provisional; Region: PRK10867 698936008997 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698936008998 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698936008999 P loop; other site 698936009000 GTP binding site [chemical binding]; other site 698936009001 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698936009002 chorismate mutase; Provisional; Region: PRK09239 698936009003 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 698936009004 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698936009005 RimM N-terminal domain; Region: RimM; pfam01782 698936009006 PRC-barrel domain; Region: PRC; pfam05239 698936009007 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698936009008 hypothetical protein; Provisional; Region: PRK10621 698936009009 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698936009010 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698936009011 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698936009012 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936009013 substrate binding pocket [chemical binding]; other site 698936009014 membrane-bound complex binding site; other site 698936009015 hinge residues; other site 698936009016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936009017 dimer interface [polypeptide binding]; other site 698936009018 conserved gate region; other site 698936009019 putative PBP binding loops; other site 698936009020 ABC-ATPase subunit interface; other site 698936009021 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698936009022 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698936009023 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698936009024 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 698936009025 Thiamine pyrophosphokinase; Region: TPK; cd07995 698936009026 active site 698936009027 dimerization interface [polypeptide binding]; other site 698936009028 thiamine binding site [chemical binding]; other site 698936009029 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 698936009030 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 698936009031 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 698936009032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936009033 ABC-ATPase subunit interface; other site 698936009034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698936009035 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 698936009036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936009037 Walker A/P-loop; other site 698936009038 ATP binding site [chemical binding]; other site 698936009039 Q-loop/lid; other site 698936009040 ABC transporter signature motif; other site 698936009041 Walker B; other site 698936009042 D-loop; other site 698936009043 H-loop/switch region; other site 698936009044 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 698936009045 Peptidase family M48; Region: Peptidase_M48; pfam01435 698936009046 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 698936009047 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 698936009048 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698936009049 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936009050 DNA binding residues [nucleotide binding] 698936009051 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 698936009052 Ferredoxin [Energy production and conversion]; Region: COG1146 698936009053 4Fe-4S binding domain; Region: Fer4; pfam00037 698936009054 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 698936009055 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698936009056 RNA binding surface [nucleotide binding]; other site 698936009057 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698936009058 ATP binding site [chemical binding]; other site 698936009059 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698936009060 putative Mg++ binding site [ion binding]; other site 698936009061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698936009062 nucleotide binding region [chemical binding]; other site 698936009063 ATP-binding site [chemical binding]; other site 698936009064 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698936009065 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 698936009066 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 698936009067 NAD(P) binding site [chemical binding]; other site 698936009068 homotetramer interface [polypeptide binding]; other site 698936009069 homodimer interface [polypeptide binding]; other site 698936009070 active site 698936009071 putative acyltransferase; Provisional; Region: PRK05790 698936009072 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698936009073 dimer interface [polypeptide binding]; other site 698936009074 active site 698936009075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 698936009076 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 698936009077 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 698936009078 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 698936009079 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 698936009080 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936009081 putative C-terminal domain interface [polypeptide binding]; other site 698936009082 putative GSH binding site (G-site) [chemical binding]; other site 698936009083 putative dimer interface [polypeptide binding]; other site 698936009084 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 698936009085 putative dimer interface [polypeptide binding]; other site 698936009086 putative N-terminal domain interface [polypeptide binding]; other site 698936009087 putative substrate binding pocket (H-site) [chemical binding]; other site 698936009088 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 698936009089 Transglycosylase; Region: Transgly; cl17702 698936009090 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698936009091 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698936009092 substrate binding pocket [chemical binding]; other site 698936009093 chain length determination region; other site 698936009094 substrate-Mg2+ binding site; other site 698936009095 catalytic residues [active] 698936009096 aspartate-rich region 1; other site 698936009097 active site lid residues [active] 698936009098 aspartate-rich region 2; other site 698936009099 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 698936009100 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936009101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936009102 homodimer interface [polypeptide binding]; other site 698936009103 catalytic residue [active] 698936009104 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698936009105 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 698936009106 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698936009107 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698936009108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936009109 putative substrate translocation pore; other site 698936009110 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698936009111 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698936009112 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698936009113 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698936009114 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936009115 substrate binding pocket [chemical binding]; other site 698936009116 membrane-bound complex binding site; other site 698936009117 hinge residues; other site 698936009118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936009119 dimer interface [polypeptide binding]; other site 698936009120 conserved gate region; other site 698936009121 putative PBP binding loops; other site 698936009122 ABC-ATPase subunit interface; other site 698936009123 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698936009124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936009125 Walker A/P-loop; other site 698936009126 ATP binding site [chemical binding]; other site 698936009127 Q-loop/lid; other site 698936009128 ABC transporter signature motif; other site 698936009129 Walker B; other site 698936009130 D-loop; other site 698936009131 H-loop/switch region; other site 698936009132 pyruvate carboxylase; Reviewed; Region: PRK12999 698936009133 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698936009134 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698936009135 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698936009136 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698936009137 active site 698936009138 catalytic residues [active] 698936009139 metal binding site [ion binding]; metal-binding site 698936009140 homodimer binding site [polypeptide binding]; other site 698936009141 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698936009142 carboxyltransferase (CT) interaction site; other site 698936009143 biotinylation site [posttranslational modification]; other site 698936009144 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 698936009145 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698936009146 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936009147 DNA binding residues [nucleotide binding] 698936009148 dimerization interface [polypeptide binding]; other site 698936009149 glucan exporter ATP-binding protein; Region: chvA; TIGR01192 698936009150 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936009151 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 698936009152 Walker A/P-loop; other site 698936009153 ATP binding site [chemical binding]; other site 698936009154 Q-loop/lid; other site 698936009155 ABC transporter signature motif; other site 698936009156 Walker B; other site 698936009157 D-loop; other site 698936009158 H-loop/switch region; other site 698936009159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645 698936009160 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 698936009161 Putative glucoamylase; Region: Glycoamylase; pfam10091 698936009162 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 698936009163 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 698936009164 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 698936009165 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698936009166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936009167 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 698936009168 dimerization interface [polypeptide binding]; other site 698936009169 substrate binding pocket [chemical binding]; other site 698936009170 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 698936009171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 698936009172 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698936009173 FAD binding domain; Region: FAD_binding_4; pfam01565 698936009174 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 698936009175 aldehyde dehydrogenase family 7 member; Region: PLN02315 698936009176 tetrameric interface [polypeptide binding]; other site 698936009177 NAD binding site [chemical binding]; other site 698936009178 catalytic residues [active] 698936009179 aspartate aminotransferase; Provisional; Region: PRK05764 698936009180 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936009181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936009182 homodimer interface [polypeptide binding]; other site 698936009183 catalytic residue [active] 698936009184 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 698936009185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936009186 non-specific DNA binding site [nucleotide binding]; other site 698936009187 salt bridge; other site 698936009188 sequence-specific DNA binding site [nucleotide binding]; other site 698936009189 Cupin domain; Region: Cupin_2; pfam07883 698936009190 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 698936009191 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698936009192 inhibitor-cofactor binding pocket; inhibition site 698936009193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936009194 catalytic residue [active] 698936009195 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 698936009196 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 698936009197 MOFRL family; Region: MOFRL; pfam05161 698936009198 choline dehydrogenase; Validated; Region: PRK02106 698936009199 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698936009200 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 698936009201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936009202 NAD(P) binding site [chemical binding]; other site 698936009203 active site 698936009204 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 698936009205 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698936009206 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936009207 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936009208 Walker A/P-loop; other site 698936009209 ATP binding site [chemical binding]; other site 698936009210 Q-loop/lid; other site 698936009211 ABC transporter signature motif; other site 698936009212 Walker B; other site 698936009213 D-loop; other site 698936009214 H-loop/switch region; other site 698936009215 TOBE domain; Region: TOBE; cl01440 698936009216 TOBE domain; Region: TOBE_2; pfam08402 698936009217 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936009218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936009219 dimer interface [polypeptide binding]; other site 698936009220 conserved gate region; other site 698936009221 putative PBP binding loops; other site 698936009222 ABC-ATPase subunit interface; other site 698936009223 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936009224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936009225 dimer interface [polypeptide binding]; other site 698936009226 conserved gate region; other site 698936009227 putative PBP binding loops; other site 698936009228 ABC-ATPase subunit interface; other site 698936009229 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936009230 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698936009231 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698936009232 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 698936009233 NAD(P) binding site [chemical binding]; other site 698936009234 catalytic residues [active] 698936009235 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698936009236 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698936009237 substrate binding site [chemical binding]; other site 698936009238 oxyanion hole (OAH) forming residues; other site 698936009239 trimer interface [polypeptide binding]; other site 698936009240 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 698936009241 Coenzyme A transferase; Region: CoA_trans; smart00882 698936009242 Coenzyme A transferase; Region: CoA_trans; cl17247 698936009243 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936009244 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936009245 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936009246 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936009247 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936009248 DNA binding site [nucleotide binding] 698936009249 domain linker motif; other site 698936009250 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 698936009251 putative dimerization interface [polypeptide binding]; other site 698936009252 putative ligand binding site [chemical binding]; other site 698936009253 Protein of unknown function (DUF993); Region: DUF993; pfam06187 698936009254 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 698936009255 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 698936009256 active site 698936009257 Zn binding site [ion binding]; other site 698936009258 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698936009259 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 698936009260 tartrate dehydrogenase; Region: TTC; TIGR02089 698936009261 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 698936009262 active site 698936009263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936009264 putative substrate translocation pore; other site 698936009265 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698936009266 oligomeric interface; other site 698936009267 putative active site [active] 698936009268 homodimer interface [polypeptide binding]; other site 698936009269 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 698936009270 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698936009271 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698936009272 Transglycosylase SLT domain; Region: SLT_2; pfam13406 698936009273 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698936009274 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698936009275 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 698936009276 active site clefts [active] 698936009277 zinc binding site [ion binding]; other site 698936009278 dimer interface [polypeptide binding]; other site 698936009279 pyridoxamine kinase; Validated; Region: PRK05756 698936009280 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 698936009281 pyridoxal binding site [chemical binding]; other site 698936009282 dimer interface [polypeptide binding]; other site 698936009283 ATP binding site [chemical binding]; other site 698936009284 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 698936009285 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 698936009286 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698936009287 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698936009288 purine monophosphate binding site [chemical binding]; other site 698936009289 dimer interface [polypeptide binding]; other site 698936009290 putative catalytic residues [active] 698936009291 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698936009292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 698936009293 NusB family; Region: NusB; pfam01029 698936009294 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 698936009295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936009296 S-adenosylmethionine binding site [chemical binding]; other site 698936009297 heat shock protein HtpX; Provisional; Region: PRK01345 698936009298 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 698936009299 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 698936009300 acetyl-CoA synthetase; Provisional; Region: PRK00174 698936009301 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 698936009302 active site 698936009303 CoA binding site [chemical binding]; other site 698936009304 acyl-activating enzyme (AAE) consensus motif; other site 698936009305 AMP binding site [chemical binding]; other site 698936009306 acetate binding site [chemical binding]; other site 698936009307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 698936009308 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 698936009309 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698936009310 acyl-activating enzyme (AAE) consensus motif; other site 698936009311 AMP binding site [chemical binding]; other site 698936009312 active site 698936009313 CoA binding site [chemical binding]; other site 698936009314 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 698936009315 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698936009316 catalytic residue [active] 698936009317 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698936009318 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 698936009319 HIGH motif; other site 698936009320 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698936009321 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698936009322 active site 698936009323 KMSKS motif; other site 698936009324 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698936009325 tRNA binding surface [nucleotide binding]; other site 698936009326 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 698936009327 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 698936009328 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698936009329 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 698936009330 ParB-like nuclease domain; Region: ParBc; pfam02195 698936009331 KorB domain; Region: KorB; pfam08535 698936009332 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698936009333 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698936009334 P-loop; other site 698936009335 Magnesium ion binding site [ion binding]; other site 698936009336 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698936009337 Magnesium ion binding site [ion binding]; other site 698936009338 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698936009339 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 698936009340 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 698936009341 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 698936009342 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 698936009343 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 698936009344 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 698936009345 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 698936009346 trmE is a tRNA modification GTPase; Region: trmE; cd04164 698936009347 G1 box; other site 698936009348 GTP/Mg2+ binding site [chemical binding]; other site 698936009349 Switch I region; other site 698936009350 G2 box; other site 698936009351 Switch II region; other site 698936009352 G3 box; other site 698936009353 G4 box; other site 698936009354 G5 box; other site 698936009355 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 698936009356 transcription termination factor Rho; Provisional; Region: rho; PRK09376 698936009357 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 698936009358 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 698936009359 RNA binding site [nucleotide binding]; other site 698936009360 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698936009361 multimer interface [polypeptide binding]; other site 698936009362 Walker A motif; other site 698936009363 ATP binding site [chemical binding]; other site 698936009364 Walker B motif; other site 698936009365 Predicted membrane protein [Function unknown]; Region: COG1981 698936009366 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698936009367 substrate binding site [chemical binding]; other site 698936009368 active site 698936009369 PEP synthetase regulatory protein; Provisional; Region: PRK05339 698936009370 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698936009371 active site 698936009372 dimer interface [polypeptide binding]; other site 698936009373 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698936009374 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698936009375 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698936009376 shikimate binding site; other site 698936009377 NAD(P) binding site [chemical binding]; other site 698936009378 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698936009379 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698936009380 CoA-binding site [chemical binding]; other site 698936009381 ATP-binding [chemical binding]; other site 698936009382 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 698936009383 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 698936009384 active site 698936009385 catalytic site [active] 698936009386 substrate binding site [chemical binding]; other site 698936009387 Preprotein translocase subunit SecB [Intracellular trafficking and secretion]; Region: SecB; COG1952 698936009388 SecA binding site; other site 698936009389 Preprotein binding site; other site 698936009390 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 698936009391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 698936009392 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 698936009393 MltA specific insert domain; Region: MltA; pfam03562 698936009394 3D domain; Region: 3D; pfam06725 698936009395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 698936009396 Smr domain; Region: Smr; pfam01713 698936009397 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698936009398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936009399 non-specific DNA binding site [nucleotide binding]; other site 698936009400 salt bridge; other site 698936009401 sequence-specific DNA binding site [nucleotide binding]; other site 698936009402 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 698936009403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936009404 Mg2+ binding site [ion binding]; other site 698936009405 G-X-G motif; other site 698936009406 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698936009407 anchoring element; other site 698936009408 dimer interface [polypeptide binding]; other site 698936009409 ATP binding site [chemical binding]; other site 698936009410 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698936009411 active site 698936009412 putative metal-binding site [ion binding]; other site 698936009413 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698936009414 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 698936009415 putative FMN binding site [chemical binding]; other site 698936009416 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 698936009417 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698936009418 tetramerization interface [polypeptide binding]; other site 698936009419 NAD(P) binding site [chemical binding]; other site 698936009420 catalytic residues [active] 698936009421 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 698936009422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 698936009423 DNA-binding site [nucleotide binding]; DNA binding site 698936009424 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936009425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 698936009426 DNA-binding site [nucleotide binding]; DNA binding site 698936009427 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698936009428 galactarate dehydratase; Region: galactar-dH20; TIGR03248 698936009429 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 698936009430 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 698936009431 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936009432 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936009433 active site 698936009434 catalytic tetrad [active] 698936009435 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 698936009436 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698936009437 putative ligand binding site [chemical binding]; other site 698936009438 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936009439 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936009440 Walker A/P-loop; other site 698936009441 ATP binding site [chemical binding]; other site 698936009442 Q-loop/lid; other site 698936009443 ABC transporter signature motif; other site 698936009444 Walker B; other site 698936009445 D-loop; other site 698936009446 H-loop/switch region; other site 698936009447 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936009448 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936009449 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936009450 TM-ABC transporter signature motif; other site 698936009451 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698936009452 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 698936009453 putative NAD(P) binding site [chemical binding]; other site 698936009454 catalytic Zn binding site [ion binding]; other site 698936009455 structural Zn binding site [ion binding]; other site 698936009456 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 698936009457 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 698936009458 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 698936009459 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 698936009460 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698936009461 active site 698936009462 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698936009463 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698936009464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936009465 catalytic residue [active] 698936009466 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698936009467 substrate binding site [chemical binding]; other site 698936009468 active site 698936009469 catalytic residues [active] 698936009470 heterodimer interface [polypeptide binding]; other site 698936009471 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 698936009472 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698936009473 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698936009474 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698936009475 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698936009476 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698936009477 catalytic residues [active] 698936009478 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 698936009479 Family description; Region: UvrD_C_2; pfam13538 698936009480 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698936009481 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 698936009482 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 698936009483 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 698936009484 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698936009485 Substrate binding site; other site 698936009486 metal-binding site 698936009487 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698936009488 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 698936009489 Phosphotransferase enzyme family; Region: APH; pfam01636 698936009490 PAS fold; Region: PAS_7; pfam12860 698936009491 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698936009492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936009493 dimer interface [polypeptide binding]; other site 698936009494 phosphorylation site [posttranslational modification] 698936009495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936009496 ATP binding site [chemical binding]; other site 698936009497 Mg2+ binding site [ion binding]; other site 698936009498 G-X-G motif; other site 698936009499 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 698936009500 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 698936009501 homotetramer interface [polypeptide binding]; other site 698936009502 ligand binding site [chemical binding]; other site 698936009503 catalytic site [active] 698936009504 NAD binding site [chemical binding]; other site 698936009505 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698936009506 dimerization domain swap beta strand [polypeptide binding]; other site 698936009507 regulatory protein interface [polypeptide binding]; other site 698936009508 active site 698936009509 regulatory phosphorylation site [posttranslational modification]; other site 698936009510 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 698936009511 active pocket/dimerization site; other site 698936009512 active site 698936009513 phosphorylation site [posttranslational modification] 698936009514 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 698936009515 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 698936009516 Hpr binding site; other site 698936009517 active site 698936009518 homohexamer subunit interaction site [polypeptide binding]; other site 698936009519 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 698936009520 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 698936009521 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936009522 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698936009523 dimerization interface [polypeptide binding]; other site 698936009524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936009525 dimer interface [polypeptide binding]; other site 698936009526 phosphorylation site [posttranslational modification] 698936009527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936009528 ATP binding site [chemical binding]; other site 698936009529 Mg2+ binding site [ion binding]; other site 698936009530 G-X-G motif; other site 698936009531 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698936009532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936009533 active site 698936009534 phosphorylation site [posttranslational modification] 698936009535 intermolecular recognition site; other site 698936009536 dimerization interface [polypeptide binding]; other site 698936009537 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936009538 DNA binding site [nucleotide binding] 698936009539 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 698936009540 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 698936009541 active site 698936009542 substrate-binding site [chemical binding]; other site 698936009543 metal-binding site [ion binding] 698936009544 ATP binding site [chemical binding]; other site 698936009545 hypothetical protein; Provisional; Region: PRK09256 698936009546 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 698936009547 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 698936009548 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698936009549 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698936009550 pantothenate kinase; Provisional; Region: PRK05439 698936009551 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 698936009552 ATP-binding site [chemical binding]; other site 698936009553 CoA-binding site [chemical binding]; other site 698936009554 Mg2+-binding site [ion binding]; other site 698936009555 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 698936009556 metal binding site [ion binding]; metal-binding site 698936009557 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698936009558 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698936009559 substrate binding site [chemical binding]; other site 698936009560 glutamase interaction surface [polypeptide binding]; other site 698936009561 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698936009562 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698936009563 catalytic residues [active] 698936009564 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 698936009565 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 698936009566 putative active site [active] 698936009567 oxyanion strand; other site 698936009568 catalytic triad [active] 698936009569 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 698936009570 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698936009571 putative active site pocket [active] 698936009572 4-fold oligomerization interface [polypeptide binding]; other site 698936009573 metal binding residues [ion binding]; metal-binding site 698936009574 3-fold/trimer interface [polypeptide binding]; other site 698936009575 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 698936009576 active site 698936009577 HslU subunit interaction site [polypeptide binding]; other site 698936009578 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698936009579 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 698936009580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698936009581 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 698936009582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936009583 Walker A motif; other site 698936009584 ATP binding site [chemical binding]; other site 698936009585 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 698936009586 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698936009587 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 698936009588 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 698936009589 Cytochrome P450; Region: p450; cl12078 698936009590 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 698936009591 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 698936009592 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 698936009593 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 698936009594 active site 698936009595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698936009596 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698936009597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5321 698936009598 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 698936009599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936009600 active site 698936009601 phosphorylation site [posttranslational modification] 698936009602 intermolecular recognition site; other site 698936009603 dimerization interface [polypeptide binding]; other site 698936009604 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 698936009605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936009606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936009607 dimer interface [polypeptide binding]; other site 698936009608 phosphorylation site [posttranslational modification] 698936009609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936009610 ATP binding site [chemical binding]; other site 698936009611 Mg2+ binding site [ion binding]; other site 698936009612 G-X-G motif; other site 698936009613 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 698936009614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698936009615 ATP binding site [chemical binding]; other site 698936009616 putative Mg++ binding site [ion binding]; other site 698936009617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698936009618 nucleotide binding region [chemical binding]; other site 698936009619 ATP-binding site [chemical binding]; other site 698936009620 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 698936009621 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 698936009622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936009623 Walker A/P-loop; other site 698936009624 ATP binding site [chemical binding]; other site 698936009625 Q-loop/lid; other site 698936009626 ABC transporter signature motif; other site 698936009627 Walker B; other site 698936009628 D-loop; other site 698936009629 H-loop/switch region; other site 698936009630 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 698936009631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936009632 dimer interface [polypeptide binding]; other site 698936009633 conserved gate region; other site 698936009634 putative PBP binding loops; other site 698936009635 ABC-ATPase subunit interface; other site 698936009636 hypothetical protein; Provisional; Region: PRK11622 698936009637 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 698936009638 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698936009639 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698936009640 O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080 698936009641 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698936009642 homodimer interface [polypeptide binding]; other site 698936009643 substrate-cofactor binding pocket; other site 698936009644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936009645 catalytic residue [active] 698936009646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936009647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936009648 LysR substrate binding domain; Region: LysR_substrate; pfam03466 698936009649 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 698936009650 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 698936009651 HPP family; Region: HPP; pfam04982 698936009652 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698936009653 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 698936009654 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 698936009655 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698936009656 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698936009657 homodimer interface [polypeptide binding]; other site 698936009658 NADP binding site [chemical binding]; other site 698936009659 substrate binding site [chemical binding]; other site 698936009660 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 698936009661 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 698936009662 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 698936009663 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698936009664 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 698936009665 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 698936009666 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936009667 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 698936009668 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 698936009669 conserved cys residue [active] 698936009670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936009671 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 698936009672 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 698936009673 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 698936009674 putative active site [active] 698936009675 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 698936009676 domain_subunit interface; other site 698936009677 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 698936009678 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 698936009679 active site 698936009680 FMN binding site [chemical binding]; other site 698936009681 substrate binding site [chemical binding]; other site 698936009682 3Fe-4S cluster binding site [ion binding]; other site 698936009683 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 698936009684 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698936009685 ethanolamine permease; Region: 2A0305; TIGR00908 698936009686 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 698936009687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936009688 non-specific DNA binding site [nucleotide binding]; other site 698936009689 salt bridge; other site 698936009690 sequence-specific DNA binding site [nucleotide binding]; other site 698936009691 Cupin domain; Region: Cupin_2; pfam07883 698936009692 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 698936009693 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 698936009694 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 698936009695 putative active site [active] 698936009696 putative substrate binding site [chemical binding]; other site 698936009697 putative cosubstrate binding site; other site 698936009698 catalytic site [active] 698936009699 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 698936009700 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698936009701 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698936009702 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 698936009703 FMN-binding pocket [chemical binding]; other site 698936009704 flavin binding motif; other site 698936009705 phosphate binding motif [ion binding]; other site 698936009706 beta-alpha-beta structure motif; other site 698936009707 NAD binding pocket [chemical binding]; other site 698936009708 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936009709 catalytic loop [active] 698936009710 iron binding site [ion binding]; other site 698936009711 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 698936009712 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 698936009713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698936009714 Uncharacterized conserved protein [Function unknown]; Region: COG3665 698936009715 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 698936009716 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698936009717 Amino acid permease; Region: AA_permease_2; pfam13520 698936009718 putative phosphoketolase; Provisional; Region: PRK05261 698936009719 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 698936009720 TPP-binding site; other site 698936009721 XFP C-terminal domain; Region: XFP_C; pfam09363 698936009722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936009723 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698936009724 NAD(P) binding site [chemical binding]; other site 698936009725 active site 698936009726 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 698936009727 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936009728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936009729 DNA-binding site [nucleotide binding]; DNA binding site 698936009730 FCD domain; Region: FCD; pfam07729 698936009731 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 698936009732 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936009733 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698936009734 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 698936009735 N-terminal domain interface [polypeptide binding]; other site 698936009736 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936009737 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936009738 Walker A/P-loop; other site 698936009739 ATP binding site [chemical binding]; other site 698936009740 Q-loop/lid; other site 698936009741 ABC transporter signature motif; other site 698936009742 Walker B; other site 698936009743 D-loop; other site 698936009744 H-loop/switch region; other site 698936009745 TOBE domain; Region: TOBE_2; pfam08402 698936009746 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936009747 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936009748 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936009749 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936009750 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936009751 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936009752 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936009753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936009754 dimer interface [polypeptide binding]; other site 698936009755 conserved gate region; other site 698936009756 putative PBP binding loops; other site 698936009757 ABC-ATPase subunit interface; other site 698936009758 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698936009759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936009760 dimer interface [polypeptide binding]; other site 698936009761 conserved gate region; other site 698936009762 putative PBP binding loops; other site 698936009763 ABC-ATPase subunit interface; other site 698936009764 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936009765 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936009766 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 698936009767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936009768 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936009769 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936009770 Protein of unknown function (DUF993); Region: DUF993; pfam06187 698936009771 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 698936009772 metal binding site [ion binding]; metal-binding site 698936009773 substrate binding pocket [chemical binding]; other site 698936009774 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936009775 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 698936009776 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936009777 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936009778 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936009779 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698936009780 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 698936009781 metal-binding site [ion binding] 698936009782 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698936009783 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 698936009784 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698936009785 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 698936009786 Transposase [DNA replication, recombination, and repair]; Region: COG5433 698936009787 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 698936009788 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936009789 Walker A/P-loop; other site 698936009790 ATP binding site [chemical binding]; other site 698936009791 Q-loop/lid; other site 698936009792 ABC transporter signature motif; other site 698936009793 Walker B; other site 698936009794 D-loop; other site 698936009795 H-loop/switch region; other site 698936009796 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936009797 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936009798 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698936009799 TM-ABC transporter signature motif; other site 698936009800 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936009801 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698936009802 TM-ABC transporter signature motif; other site 698936009803 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 698936009804 active site 698936009805 catalytic motif [active] 698936009806 Zn binding site [ion binding]; other site 698936009807 purine nucleoside phosphorylase; Provisional; Region: PRK08202 698936009808 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 698936009809 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698936009810 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698936009811 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 698936009812 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698936009813 active site 698936009814 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 698936009815 adenosine deaminase; Provisional; Region: PRK09358 698936009816 active site 698936009817 phosphopentomutase; Provisional; Region: PRK05362 698936009818 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 698936009819 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 698936009820 TadE-like protein; Region: TadE; pfam07811 698936009821 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 698936009822 TadE-like protein; Region: TadE; pfam07811 698936009823 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 698936009824 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 698936009825 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 698936009826 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 698936009827 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 698936009828 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 698936009829 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 698936009830 BON domain; Region: BON; pfam04972 698936009831 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 698936009832 Type IV pili component [Cell motility and secretion]; Region: COG5461 698936009833 pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522 698936009834 AAA domain; Region: AAA_31; pfam13614 698936009835 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 698936009836 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698936009837 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 698936009838 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698936009839 ATP binding site [chemical binding]; other site 698936009840 Walker A motif; other site 698936009841 hexamer interface [polypeptide binding]; other site 698936009842 Walker B motif; other site 698936009843 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698936009844 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 698936009845 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 698936009846 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 698936009847 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 698936009848 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 698936009849 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698936009850 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 698936009851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936009852 TPR motif; other site 698936009853 binding surface 698936009854 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 698936009855 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698936009856 interface (dimer of trimers) [polypeptide binding]; other site 698936009857 Substrate-binding/catalytic site; other site 698936009858 Zn-binding sites [ion binding]; other site 698936009859 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698936009860 MarR family; Region: MarR; pfam01047 698936009861 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698936009862 NlpC/P60 family; Region: NLPC_P60; cl17555 698936009863 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698936009864 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 698936009865 putative ligand binding site [chemical binding]; other site 698936009866 NAD binding site [chemical binding]; other site 698936009867 dimerization interface [polypeptide binding]; other site 698936009868 catalytic site [active] 698936009869 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 698936009870 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936009871 Walker A/P-loop; other site 698936009872 ATP binding site [chemical binding]; other site 698936009873 Q-loop/lid; other site 698936009874 ABC transporter signature motif; other site 698936009875 Walker B; other site 698936009876 D-loop; other site 698936009877 H-loop/switch region; other site 698936009878 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698936009879 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936009880 Walker A/P-loop; other site 698936009881 ATP binding site [chemical binding]; other site 698936009882 Q-loop/lid; other site 698936009883 ABC transporter signature motif; other site 698936009884 Walker B; other site 698936009885 D-loop; other site 698936009886 H-loop/switch region; other site 698936009887 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936009888 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 698936009889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936009890 dimer interface [polypeptide binding]; other site 698936009891 conserved gate region; other site 698936009892 putative PBP binding loops; other site 698936009893 ABC-ATPase subunit interface; other site 698936009894 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 698936009895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936009896 dimer interface [polypeptide binding]; other site 698936009897 conserved gate region; other site 698936009898 putative PBP binding loops; other site 698936009899 ABC-ATPase subunit interface; other site 698936009900 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 698936009901 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 698936009902 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 698936009903 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 698936009904 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 698936009905 active site 698936009906 dimer interfaces [polypeptide binding]; other site 698936009907 catalytic residues [active] 698936009908 glucokinase; Provisional; Region: glk; PRK00292 698936009909 glucokinase, proteobacterial type; Region: glk; TIGR00749 698936009910 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698936009911 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936009912 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 698936009913 Walker A/P-loop; other site 698936009914 ATP binding site [chemical binding]; other site 698936009915 Q-loop/lid; other site 698936009916 ABC transporter signature motif; other site 698936009917 Walker B; other site 698936009918 D-loop; other site 698936009919 H-loop/switch region; other site 698936009920 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 698936009921 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698936009922 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698936009923 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698936009924 catalytic core [active] 698936009925 Helix-turn-helix domain; Region: HTH_18; pfam12833 698936009926 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 698936009927 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698936009928 DNA binding site [nucleotide binding] 698936009929 active site 698936009930 Integral membrane protein [Function unknown]; Region: COG5488 698936009931 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698936009932 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698936009933 minor groove reading motif; other site 698936009934 helix-hairpin-helix signature motif; other site 698936009935 substrate binding pocket [chemical binding]; other site 698936009936 active site 698936009937 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 698936009938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936009939 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 698936009940 putative dimer interface [polypeptide binding]; other site 698936009941 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936009942 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 698936009943 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698936009944 substrate binding site [chemical binding]; other site 698936009945 ATP binding site [chemical binding]; other site 698936009946 Predicted kinase [General function prediction only]; Region: COG0645 698936009947 AAA domain; Region: AAA_17; pfam13207 698936009948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 698936009949 Bacterial SH3 domain; Region: SH3_4; pfam06347 698936009950 Bacterial SH3 domain; Region: SH3_4; pfam06347 698936009951 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 698936009952 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 698936009953 dimerization interface [polypeptide binding]; other site 698936009954 ligand binding site [chemical binding]; other site 698936009955 NADP binding site [chemical binding]; other site 698936009956 catalytic site [active] 698936009957 5'-3' exonuclease; Region: 53EXOc; smart00475 698936009958 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698936009959 active site 698936009960 metal binding site 1 [ion binding]; metal-binding site 698936009961 putative 5' ssDNA interaction site; other site 698936009962 metal binding site 3; metal-binding site 698936009963 metal binding site 2 [ion binding]; metal-binding site 698936009964 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698936009965 putative DNA binding site [nucleotide binding]; other site 698936009966 putative metal binding site [ion binding]; other site 698936009967 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 698936009968 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 698936009969 active site 698936009970 catalytic site [active] 698936009971 substrate binding site [chemical binding]; other site 698936009972 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698936009973 active site 698936009974 DNA binding site [nucleotide binding] 698936009975 catalytic site [active] 698936009976 MarR family; Region: MarR; pfam01047 698936009977 hypothetical protein; Validated; Region: PRK09104 698936009978 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 698936009979 metal binding site [ion binding]; metal-binding site 698936009980 putative dimer interface [polypeptide binding]; other site 698936009981 Predicted integral membrane protein [Function unknown]; Region: COG0392 698936009982 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698936009983 EamA-like transporter family; Region: EamA; pfam00892 698936009984 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698936009985 Transglycosylase; Region: Transgly; pfam00912 698936009986 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698936009987 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698936009988 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 698936009989 nucleotide binding site [chemical binding]; other site 698936009990 NEF interaction site [polypeptide binding]; other site 698936009991 SBD interface [polypeptide binding]; other site 698936009992 chaperone protein DnaJ; Provisional; Region: PRK10767 698936009993 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698936009994 HSP70 interaction site [polypeptide binding]; other site 698936009995 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 698936009996 substrate binding site [polypeptide binding]; other site 698936009997 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698936009998 Zn binding sites [ion binding]; other site 698936009999 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698936010000 dimer interface [polypeptide binding]; other site 698936010001 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 698936010002 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 698936010003 Uncharacterized conserved protein [Function unknown]; Region: COG5588 698936010004 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698936010005 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 698936010006 recombination protein F; Reviewed; Region: recF; PRK00064 698936010007 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698936010008 Walker A/P-loop; other site 698936010009 ATP binding site [chemical binding]; other site 698936010010 Q-loop/lid; other site 698936010011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936010012 ABC transporter signature motif; other site 698936010013 Walker B; other site 698936010014 D-loop; other site 698936010015 H-loop/switch region; other site 698936010016 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 698936010017 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698936010018 ATP binding site [chemical binding]; other site 698936010019 substrate interface [chemical binding]; other site 698936010020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936010021 Coenzyme A binding pocket [chemical binding]; other site 698936010022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936010023 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 698936010024 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 698936010025 Protein export membrane protein; Region: SecD_SecF; cl14618 698936010026 Protein export membrane protein; Region: SecD_SecF; cl14618 698936010027 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 698936010028 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936010029 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936010030 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936010031 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936010032 Walker A/P-loop; other site 698936010033 ATP binding site [chemical binding]; other site 698936010034 Q-loop/lid; other site 698936010035 ABC transporter signature motif; other site 698936010036 Walker B; other site 698936010037 D-loop; other site 698936010038 H-loop/switch region; other site 698936010039 TOBE domain; Region: TOBE_2; pfam08402 698936010040 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936010041 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936010042 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936010043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936010044 dimer interface [polypeptide binding]; other site 698936010045 conserved gate region; other site 698936010046 putative PBP binding loops; other site 698936010047 ABC-ATPase subunit interface; other site 698936010048 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936010049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936010050 dimer interface [polypeptide binding]; other site 698936010051 conserved gate region; other site 698936010052 putative PBP binding loops; other site 698936010053 ABC-ATPase subunit interface; other site 698936010054 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936010055 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936010056 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 698936010057 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 698936010058 putative active site [active] 698936010059 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 698936010060 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698936010061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936010062 DNA-binding site [nucleotide binding]; DNA binding site 698936010063 UTRA domain; Region: UTRA; pfam07702 698936010064 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 698936010065 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698936010066 dimer interface [polypeptide binding]; other site 698936010067 active site 698936010068 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698936010069 dimer interface [polypeptide binding]; other site 698936010070 active site 698936010071 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698936010072 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698936010073 active site 698936010074 dimer interface [polypeptide binding]; other site 698936010075 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 698936010076 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698936010077 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698936010078 hypothetical protein; Provisional; Region: PRK06102 698936010079 Amidase; Region: Amidase; cl11426 698936010080 CysZ-like protein; Reviewed; Region: PRK12768 698936010081 hypothetical protein; Provisional; Region: PRK00736 698936010082 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 698936010083 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 698936010084 ligand binding site [chemical binding]; other site 698936010085 methionine sulfoxide reductase A; Provisional; Region: PRK00058 698936010086 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 698936010087 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936010088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936010089 muropeptide transporter; Validated; Region: ampG; cl17669 698936010090 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 698936010091 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 698936010092 N-terminal plug; other site 698936010093 ligand-binding site [chemical binding]; other site 698936010094 hypothetical protein; Provisional; Region: PRK07588 698936010095 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698936010096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936010097 putative substrate translocation pore; other site 698936010098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936010099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936010100 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936010101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936010102 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 698936010103 putative substrate binding pocket [chemical binding]; other site 698936010104 putative dimerization interface [polypeptide binding]; other site 698936010105 Predicted permeases [General function prediction only]; Region: COG0679 698936010106 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698936010107 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698936010108 homodimer interface [polypeptide binding]; other site 698936010109 substrate-cofactor binding pocket; other site 698936010110 catalytic residue [active] 698936010111 Cytochrome c2 [Energy production and conversion]; Region: COG3474 698936010112 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 698936010113 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 698936010114 Ligand binding site; other site 698936010115 oligomer interface; other site 698936010116 prephenate dehydratase; Provisional; Region: PRK11899 698936010117 Prephenate dehydratase; Region: PDT; pfam00800 698936010118 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698936010119 putative L-Phe binding site [chemical binding]; other site 698936010120 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 698936010121 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 698936010122 putative dimer interface [polypeptide binding]; other site 698936010123 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936010124 Predicted transcriptional regulator [Transcription]; Region: COG2378 698936010125 HTH domain; Region: HTH_11; pfam08279 698936010126 WYL domain; Region: WYL; pfam13280 698936010127 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 698936010128 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 698936010129 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 698936010130 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 698936010131 putative NADH binding site [chemical binding]; other site 698936010132 putative active site [active] 698936010133 nudix motif; other site 698936010134 putative metal binding site [ion binding]; other site 698936010135 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 698936010136 nucleotide binding site/active site [active] 698936010137 HIT family signature motif; other site 698936010138 catalytic residue [active] 698936010139 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 698936010140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936010141 Walker A motif; other site 698936010142 ATP binding site [chemical binding]; other site 698936010143 Walker B motif; other site 698936010144 arginine finger; other site 698936010145 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698936010146 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 698936010147 hypothetical protein; Validated; Region: PRK00153 698936010148 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698936010149 recombination protein RecR; Reviewed; Region: recR; PRK00076 698936010150 RecR protein; Region: RecR; pfam02132 698936010151 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698936010152 putative active site [active] 698936010153 putative metal-binding site [ion binding]; other site 698936010154 tetramer interface [polypeptide binding]; other site 698936010155 Transglycosylase SLT domain; Region: SLT_2; pfam13406 698936010156 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698936010157 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698936010158 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698936010159 Transmembrane secretion effector; Region: MFS_3; pfam05977 698936010160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936010161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936010162 ribosome maturation protein RimP; Reviewed; Region: PRK00092 698936010163 Sm and related proteins; Region: Sm_like; cl00259 698936010164 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 698936010165 putative oligomer interface [polypeptide binding]; other site 698936010166 putative RNA binding site [nucleotide binding]; other site 698936010167 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 698936010168 NusA N-terminal domain; Region: NusA_N; pfam08529 698936010169 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698936010170 RNA binding site [nucleotide binding]; other site 698936010171 homodimer interface [polypeptide binding]; other site 698936010172 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698936010173 G-X-X-G motif; other site 698936010174 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698936010175 G-X-X-G motif; other site 698936010176 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 698936010177 hypothetical protein; Provisional; Region: PRK09190 698936010178 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 698936010179 putative RNA binding cleft [nucleotide binding]; other site 698936010180 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 698936010181 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698936010182 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 698936010183 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698936010184 G1 box; other site 698936010185 putative GEF interaction site [polypeptide binding]; other site 698936010186 GTP/Mg2+ binding site [chemical binding]; other site 698936010187 Switch I region; other site 698936010188 G2 box; other site 698936010189 G3 box; other site 698936010190 Switch II region; other site 698936010191 G4 box; other site 698936010192 G5 box; other site 698936010193 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698936010194 Translation-initiation factor 2; Region: IF-2; pfam11987 698936010195 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698936010196 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698936010197 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 698936010198 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698936010199 RNA binding site [nucleotide binding]; other site 698936010200 active site 698936010201 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 698936010202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698936010203 HWE histidine kinase; Region: HWE_HK; pfam07536 698936010204 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698936010205 16S/18S rRNA binding site [nucleotide binding]; other site 698936010206 S13e-L30e interaction site [polypeptide binding]; other site 698936010207 25S rRNA binding site [nucleotide binding]; other site 698936010208 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 698936010209 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 698936010210 RNase E interface [polypeptide binding]; other site 698936010211 trimer interface [polypeptide binding]; other site 698936010212 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698936010213 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698936010214 RNase E interface [polypeptide binding]; other site 698936010215 trimer interface [polypeptide binding]; other site 698936010216 active site 698936010217 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698936010218 putative nucleic acid binding region [nucleotide binding]; other site 698936010219 G-X-X-G motif; other site 698936010220 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698936010221 RNA binding site [nucleotide binding]; other site 698936010222 domain interface; other site 698936010223 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 698936010224 Methyltransferase small domain; Region: MTS; pfam05175 698936010225 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 698936010226 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 698936010227 NAD binding site [chemical binding]; other site 698936010228 homotetramer interface [polypeptide binding]; other site 698936010229 homodimer interface [polypeptide binding]; other site 698936010230 substrate binding site [chemical binding]; other site 698936010231 active site 698936010232 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 698936010233 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 698936010234 dimer interface [polypeptide binding]; other site 698936010235 active site 698936010236 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 698936010237 active site 1 [active] 698936010238 dimer interface [polypeptide binding]; other site 698936010239 active site 2 [active] 698936010240 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698936010241 metal binding site 2 [ion binding]; metal-binding site 698936010242 putative DNA binding helix; other site 698936010243 metal binding site 1 [ion binding]; metal-binding site 698936010244 dimer interface [polypeptide binding]; other site 698936010245 Predicted membrane protein [Function unknown]; Region: COG2860 698936010246 UPF0126 domain; Region: UPF0126; pfam03458 698936010247 UPF0126 domain; Region: UPF0126; pfam03458 698936010248 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698936010249 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698936010250 putative active site [active] 698936010251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 698936010252 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 698936010253 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698936010254 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698936010255 hinge; other site 698936010256 active site 698936010257 cytidylate kinase; Provisional; Region: cmk; PRK00023 698936010258 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698936010259 CMP-binding site; other site 698936010260 The sites determining sugar specificity; other site 698936010261 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 698936010262 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698936010263 RNA binding site [nucleotide binding]; other site 698936010264 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698936010265 RNA binding site [nucleotide binding]; other site 698936010266 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 698936010267 RNA binding site [nucleotide binding]; other site 698936010268 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698936010269 RNA binding site [nucleotide binding]; other site 698936010270 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698936010271 RNA binding site [nucleotide binding]; other site 698936010272 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 698936010273 RNA binding site [nucleotide binding]; other site 698936010274 BA14K-like protein; Region: BA14K; pfam07886 698936010275 Cache domain; Region: Cache_1; pfam02743 698936010276 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 698936010277 dimerization interface [polypeptide binding]; other site 698936010278 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936010279 cyclase homology domain; Region: CHD; cd07302 698936010280 nucleotidyl binding site; other site 698936010281 metal binding site [ion binding]; metal-binding site 698936010282 dimer interface [polypeptide binding]; other site 698936010283 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698936010284 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 698936010285 putative ligand binding site [chemical binding]; other site 698936010286 putative NAD binding site [chemical binding]; other site 698936010287 catalytic site [active] 698936010288 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698936010289 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698936010290 catalytic site [active] 698936010291 putative active site [active] 698936010292 putative substrate binding site [chemical binding]; other site 698936010293 Helix-turn-helix domain; Region: HTH_28; pfam13518 698936010294 Winged helix-turn helix; Region: HTH_29; pfam13551 698936010295 Homeodomain-like domain; Region: HTH_32; pfam13565 698936010296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698936010297 Integrase core domain; Region: rve; pfam00665 698936010298 Integrase core domain; Region: rve_3; pfam13683 698936010299 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 698936010300 GIY-YIG motif/motif A; other site 698936010301 putative active site [active] 698936010302 putative metal binding site [ion binding]; other site 698936010303 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 698936010304 Predicted membrane protein [Function unknown]; Region: COG2259 698936010305 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 698936010306 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698936010307 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 698936010308 GTP-binding protein LepA; Provisional; Region: PRK05433 698936010309 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698936010310 G1 box; other site 698936010311 putative GEF interaction site [polypeptide binding]; other site 698936010312 GTP/Mg2+ binding site [chemical binding]; other site 698936010313 Switch I region; other site 698936010314 G2 box; other site 698936010315 G3 box; other site 698936010316 Switch II region; other site 698936010317 G4 box; other site 698936010318 G5 box; other site 698936010319 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698936010320 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698936010321 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698936010322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936010323 putative substrate translocation pore; other site 698936010324 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698936010325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936010326 sequence-specific DNA binding site [nucleotide binding]; other site 698936010327 salt bridge; other site 698936010328 Cupin domain; Region: Cupin_2; pfam07883 698936010329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936010330 Coenzyme A binding pocket [chemical binding]; other site 698936010331 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 698936010332 putative outer membrane lipoprotein; Provisional; Region: PRK10510 698936010333 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 698936010334 ligand binding site [chemical binding]; other site 698936010335 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 698936010336 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698936010337 FeS/SAM binding site; other site 698936010338 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 698936010339 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698936010340 motif 1; other site 698936010341 dimer interface [polypeptide binding]; other site 698936010342 active site 698936010343 motif 2; other site 698936010344 motif 3; other site 698936010345 elongation factor P; Validated; Region: PRK00529 698936010346 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698936010347 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698936010348 RNA binding site [nucleotide binding]; other site 698936010349 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698936010350 RNA binding site [nucleotide binding]; other site 698936010351 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698936010352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698936010353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936010354 S-adenosylmethionine binding site [chemical binding]; other site 698936010355 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 698936010356 diiron binding motif [ion binding]; other site 698936010357 Uncharacterized conserved protein [Function unknown]; Region: COG1633 698936010358 CCC1-related protein family; Region: CCC1_like_1; cd02437 698936010359 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 698936010360 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698936010361 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698936010362 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698936010363 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698936010364 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698936010365 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698936010366 23S rRNA binding site [nucleotide binding]; other site 698936010367 L21 binding site [polypeptide binding]; other site 698936010368 L13 binding site [polypeptide binding]; other site 698936010369 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698936010370 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698936010371 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698936010372 dimer interface [polypeptide binding]; other site 698936010373 motif 1; other site 698936010374 active site 698936010375 motif 2; other site 698936010376 motif 3; other site 698936010377 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698936010378 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698936010379 putative tRNA-binding site [nucleotide binding]; other site 698936010380 B3/4 domain; Region: B3_4; pfam03483 698936010381 tRNA synthetase B5 domain; Region: B5; smart00874 698936010382 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698936010383 dimer interface [polypeptide binding]; other site 698936010384 motif 1; other site 698936010385 motif 3; other site 698936010386 motif 2; other site 698936010387 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 698936010388 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 698936010389 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936010390 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936010391 active site 698936010392 catalytic tetrad [active] 698936010393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936010394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936010395 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698936010396 putative effector binding pocket; other site 698936010397 putative dimerization interface [polypeptide binding]; other site 698936010398 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 698936010399 dimerization interface [polypeptide binding]; other site 698936010400 metal binding site [ion binding]; metal-binding site 698936010401 short chain dehydrogenase; Provisional; Region: PRK07478 698936010402 classical (c) SDRs; Region: SDR_c; cd05233 698936010403 NAD(P) binding site [chemical binding]; other site 698936010404 active site 698936010405 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936010406 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936010407 active site 698936010408 catalytic tetrad [active] 698936010409 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936010410 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936010411 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936010412 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698936010413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936010414 non-specific DNA binding site [nucleotide binding]; other site 698936010415 salt bridge; other site 698936010416 sequence-specific DNA binding site [nucleotide binding]; other site 698936010417 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 698936010418 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698936010419 generic binding surface II; other site 698936010420 generic binding surface I; other site 698936010421 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 698936010422 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698936010423 MarR family; Region: MarR_2; cl17246 698936010424 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698936010425 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 698936010426 EamA-like transporter family; Region: EamA; pfam00892 698936010427 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 698936010428 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 698936010429 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936010430 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 698936010431 C-terminal domain interface [polypeptide binding]; other site 698936010432 GSH binding site (G-site) [chemical binding]; other site 698936010433 dimer interface [polypeptide binding]; other site 698936010434 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 698936010435 N-terminal domain interface [polypeptide binding]; other site 698936010436 dimer interface [polypeptide binding]; other site 698936010437 substrate binding pocket (H-site) [chemical binding]; other site 698936010438 MarR family; Region: MarR_2; pfam12802 698936010439 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698936010440 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 698936010441 putative deacylase active site [active] 698936010442 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 698936010443 ArsC family; Region: ArsC; pfam03960 698936010444 putative catalytic residues [active] 698936010445 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 698936010446 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936010447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936010448 homodimer interface [polypeptide binding]; other site 698936010449 catalytic residue [active] 698936010450 Predicted deacylase [General function prediction only]; Region: COG3608 698936010451 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 698936010452 active site 698936010453 Zn binding site [ion binding]; other site 698936010454 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 698936010455 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 698936010456 putative active site [active] 698936010457 GMP synthase; Reviewed; Region: guaA; PRK00074 698936010458 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698936010459 AMP/PPi binding site [chemical binding]; other site 698936010460 candidate oxyanion hole; other site 698936010461 catalytic triad [active] 698936010462 potential glutamine specificity residues [chemical binding]; other site 698936010463 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698936010464 ATP Binding subdomain [chemical binding]; other site 698936010465 Ligand Binding sites [chemical binding]; other site 698936010466 Dimerization subdomain; other site 698936010467 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 698936010468 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 698936010469 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698936010470 CoenzymeA binding site [chemical binding]; other site 698936010471 subunit interaction site [polypeptide binding]; other site 698936010472 PHB binding site; other site 698936010473 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698936010474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936010475 Coenzyme A binding pocket [chemical binding]; other site 698936010476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 698936010477 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698936010478 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 698936010479 Cl binding site [ion binding]; other site 698936010480 oligomer interface [polypeptide binding]; other site 698936010481 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG3489 698936010482 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 698936010483 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 698936010484 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 698936010485 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 698936010486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936010487 S-adenosylmethionine binding site [chemical binding]; other site 698936010488 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 698936010489 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 698936010490 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936010491 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 698936010492 putative NAD(P) binding site [chemical binding]; other site 698936010493 epoxyqueuosine reductase; Region: TIGR00276 698936010494 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 698936010495 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936010496 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 698936010497 C-terminal domain interface [polypeptide binding]; other site 698936010498 GSH binding site (G-site) [chemical binding]; other site 698936010499 dimer interface [polypeptide binding]; other site 698936010500 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 698936010501 N-terminal domain interface [polypeptide binding]; other site 698936010502 dimer interface [polypeptide binding]; other site 698936010503 substrate binding pocket (H-site) [chemical binding]; other site 698936010504 Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968 698936010505 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698936010506 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 698936010507 putative NAD(P) binding site [chemical binding]; other site 698936010508 active site 698936010509 Uncharacterized conserved protein [Function unknown]; Region: COG5470 698936010510 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698936010511 active site 698936010512 dimer interface [polypeptide binding]; other site 698936010513 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698936010514 catalytic core [active] 698936010515 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698936010516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936010517 S-adenosylmethionine binding site [chemical binding]; other site 698936010518 DNA polymerase III subunit beta; Validated; Region: PRK05643 698936010519 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698936010520 putative DNA binding surface [nucleotide binding]; other site 698936010521 dimer interface [polypeptide binding]; other site 698936010522 beta-clamp/clamp loader binding surface; other site 698936010523 beta-clamp/translesion DNA polymerase binding surface; other site 698936010524 Predicted methyltransferases [General function prediction only]; Region: COG0313 698936010525 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698936010526 putative SAM binding site [chemical binding]; other site 698936010527 putative homodimer interface [polypeptide binding]; other site 698936010528 hypothetical protein; Reviewed; Region: PRK12497 698936010529 glutathione synthetase; Provisional; Region: PRK05246 698936010530 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 698936010531 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 698936010532 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 698936010533 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698936010534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936010535 Walker A motif; other site 698936010536 ATP binding site [chemical binding]; other site 698936010537 Walker B motif; other site 698936010538 arginine finger; other site 698936010539 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 698936010540 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698936010541 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698936010542 dimer interface [polypeptide binding]; other site 698936010543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936010544 catalytic residue [active] 698936010545 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698936010546 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698936010547 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 698936010548 EamA-like transporter family; Region: EamA; pfam00892 698936010549 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936010550 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936010551 putative DNA binding site [nucleotide binding]; other site 698936010552 putative Zn2+ binding site [ion binding]; other site 698936010553 AsnC family; Region: AsnC_trans_reg; pfam01037 698936010554 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698936010555 trimer interface [polypeptide binding]; other site 698936010556 active site 698936010557 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 698936010558 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698936010559 G1 box; other site 698936010560 putative GEF interaction site [polypeptide binding]; other site 698936010561 GTP/Mg2+ binding site [chemical binding]; other site 698936010562 Switch I region; other site 698936010563 G2 box; other site 698936010564 G3 box; other site 698936010565 Switch II region; other site 698936010566 G4 box; other site 698936010567 G5 box; other site 698936010568 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 698936010569 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698936010570 EamA-like transporter family; Region: EamA; pfam00892 698936010571 EamA-like transporter family; Region: EamA; pfam00892 698936010572 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698936010573 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698936010574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936010575 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936010576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936010577 NAD(P) binding site [chemical binding]; other site 698936010578 active site 698936010579 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698936010580 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 698936010581 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936010582 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 698936010583 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698936010584 dimer interface [polypeptide binding]; other site 698936010585 PYR/PP interface [polypeptide binding]; other site 698936010586 TPP binding site [chemical binding]; other site 698936010587 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698936010588 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 698936010589 TPP-binding site [chemical binding]; other site 698936010590 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698936010591 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 698936010592 substrate binding site [chemical binding]; other site 698936010593 ATP binding site [chemical binding]; other site 698936010594 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 698936010595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 698936010596 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698936010597 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698936010598 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698936010599 putative active site [active] 698936010600 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936010601 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936010602 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936010603 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 698936010604 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 698936010605 putative active site [active] 698936010606 putative dimer interface [polypeptide binding]; other site 698936010607 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698936010608 Flavoprotein; Region: Flavoprotein; pfam02441 698936010609 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698936010610 Predicted transcriptional regulator [Transcription]; Region: COG1959 698936010611 Transcriptional regulator; Region: Rrf2; pfam02082 698936010612 Transcriptional regulator; Region: Rrf2; cl17282 698936010613 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 698936010614 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 698936010615 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 698936010616 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 698936010617 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 698936010618 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936010619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936010620 NAD(P) binding site [chemical binding]; other site 698936010621 active site 698936010622 ABC1 family; Region: ABC1; cl17513 698936010623 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 698936010624 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698936010625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936010626 S-adenosylmethionine binding site [chemical binding]; other site 698936010627 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698936010628 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698936010629 DNA binding site [nucleotide binding] 698936010630 catalytic residue [active] 698936010631 H2TH interface [polypeptide binding]; other site 698936010632 putative catalytic residues [active] 698936010633 turnover-facilitating residue; other site 698936010634 intercalation triad [nucleotide binding]; other site 698936010635 8OG recognition residue [nucleotide binding]; other site 698936010636 putative reading head residues; other site 698936010637 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698936010638 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698936010639 enoyl-CoA hydratase; Provisional; Region: PRK05862 698936010640 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698936010641 substrate binding site [chemical binding]; other site 698936010642 oxyanion hole (OAH) forming residues; other site 698936010643 trimer interface [polypeptide binding]; other site 698936010644 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698936010645 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 698936010646 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698936010647 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698936010648 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 698936010649 PAS domain S-box; Region: sensory_box; TIGR00229 698936010650 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936010651 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936010652 metal binding site [ion binding]; metal-binding site 698936010653 active site 698936010654 I-site; other site 698936010655 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698936010656 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936010657 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936010658 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936010659 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936010660 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936010661 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 698936010662 putative dimerization interface [polypeptide binding]; other site 698936010663 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 698936010664 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 698936010665 putative ligand binding site [chemical binding]; other site 698936010666 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936010667 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936010668 Walker A/P-loop; other site 698936010669 ATP binding site [chemical binding]; other site 698936010670 Q-loop/lid; other site 698936010671 ABC transporter signature motif; other site 698936010672 Walker B; other site 698936010673 D-loop; other site 698936010674 H-loop/switch region; other site 698936010675 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936010676 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936010677 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936010678 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936010679 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936010680 TM-ABC transporter signature motif; other site 698936010681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 698936010682 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698936010683 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 698936010684 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698936010685 NAD(P) binding site [chemical binding]; other site 698936010686 catalytic residues [active] 698936010687 dihydroxy-acid dehydratase; Validated; Region: PRK06131 698936010688 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 698936010689 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 698936010690 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 698936010691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 698936010692 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 698936010693 Uncharacterized conserved protein [Function unknown]; Region: COG2308 698936010694 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698936010695 EamA-like transporter family; Region: EamA; pfam00892 698936010696 YtkA-like; Region: YtkA; pfam13115 698936010697 Predicted metal-binding protein [General function prediction only]; Region: COG3019 698936010698 helicase 45; Provisional; Region: PTZ00424 698936010699 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698936010700 ATP binding site [chemical binding]; other site 698936010701 Mg++ binding site [ion binding]; other site 698936010702 motif III; other site 698936010703 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698936010704 nucleotide binding region [chemical binding]; other site 698936010705 ATP-binding site [chemical binding]; other site 698936010706 Protein required for attachment to host cells [Cell motility and secretion]; Region: COG5622 698936010707 Uncharacterized conserved protein [Function unknown]; Region: COG4121 698936010708 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936010709 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 698936010710 Protein of unknown function (DUF1045); Region: DUF1045; pfam06299 698936010711 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 698936010712 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 698936010713 active site 698936010714 catalytic site [active] 698936010715 tetramer interface [polypeptide binding]; other site 698936010716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 698936010717 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 698936010718 ureidoglycolate hydrolase; Provisional; Region: PRK03606 698936010719 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 698936010720 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 698936010721 putative active site [active] 698936010722 putative NTP binding site [chemical binding]; other site 698936010723 putative nucleic acid binding site [nucleotide binding]; other site 698936010724 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 698936010725 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698936010726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698936010727 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 698936010728 active site 698936010729 homotetramer interface [polypeptide binding]; other site 698936010730 short chain dehydrogenase; Provisional; Region: PRK06500 698936010731 classical (c) SDRs; Region: SDR_c; cd05233 698936010732 NAD(P) binding site [chemical binding]; other site 698936010733 active site 698936010734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936010735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936010736 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698936010737 putative effector binding pocket; other site 698936010738 dimerization interface [polypeptide binding]; other site 698936010739 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 698936010740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936010741 active site 698936010742 phosphorylation site [posttranslational modification] 698936010743 intermolecular recognition site; other site 698936010744 dimerization interface [polypeptide binding]; other site 698936010745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936010746 DNA binding residues [nucleotide binding] 698936010747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936010748 active site 698936010749 phosphorylation site [posttranslational modification] 698936010750 intermolecular recognition site; other site 698936010751 dimerization interface [polypeptide binding]; other site 698936010752 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 698936010753 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936010754 PAS fold; Region: PAS_3; pfam08447 698936010755 putative active site [active] 698936010756 heme pocket [chemical binding]; other site 698936010757 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936010758 PAS domain; Region: PAS_9; pfam13426 698936010759 putative active site [active] 698936010760 heme pocket [chemical binding]; other site 698936010761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936010762 PAS fold; Region: PAS_3; pfam08447 698936010763 putative active site [active] 698936010764 heme pocket [chemical binding]; other site 698936010765 PAS fold; Region: PAS_3; pfam08447 698936010766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936010767 putative active site [active] 698936010768 heme pocket [chemical binding]; other site 698936010769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936010770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936010771 ATP binding site [chemical binding]; other site 698936010772 Mg2+ binding site [ion binding]; other site 698936010773 G-X-G motif; other site 698936010774 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698936010775 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698936010776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936010777 NAD(P) binding site [chemical binding]; other site 698936010778 active site 698936010779 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 698936010780 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698936010781 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698936010782 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698936010783 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936010784 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698936010785 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936010786 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698936010787 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936010788 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 698936010789 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 698936010790 FMN binding site [chemical binding]; other site 698936010791 glucose-6-phosphate isomerase; Provisional; Region: PRK04190 698936010792 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 698936010793 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 698936010794 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698936010795 putative ligand binding site [chemical binding]; other site 698936010796 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936010797 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936010798 Walker A/P-loop; other site 698936010799 ATP binding site [chemical binding]; other site 698936010800 Q-loop/lid; other site 698936010801 ABC transporter signature motif; other site 698936010802 Walker B; other site 698936010803 D-loop; other site 698936010804 H-loop/switch region; other site 698936010805 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936010806 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936010807 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936010808 TM-ABC transporter signature motif; other site 698936010809 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698936010810 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 698936010811 putative NAD(P) binding site [chemical binding]; other site 698936010812 catalytic Zn binding site [ion binding]; other site 698936010813 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 698936010814 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 698936010815 N- and C-terminal domain interface [polypeptide binding]; other site 698936010816 active site 698936010817 MgATP binding site [chemical binding]; other site 698936010818 catalytic site [active] 698936010819 metal binding site [ion binding]; metal-binding site 698936010820 putative carbohydrate binding site [chemical binding]; other site 698936010821 putative homodimer interface [polypeptide binding]; other site 698936010822 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698936010823 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 698936010824 DNA binding residues [nucleotide binding] 698936010825 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698936010826 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 698936010827 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 698936010828 active site 698936010829 substrate binding site [chemical binding]; other site 698936010830 FMN binding site [chemical binding]; other site 698936010831 putative catalytic residues [active] 698936010832 guanine deaminase; Provisional; Region: PRK09228 698936010833 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 698936010834 active site 698936010835 Predicted membrane protein [Function unknown]; Region: COG3748 698936010836 Protein of unknown function (DUF989); Region: DUF989; pfam06181 698936010837 Cytochrome c; Region: Cytochrom_C; pfam00034 698936010838 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698936010839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936010840 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 698936010841 dimerization interface [polypeptide binding]; other site 698936010842 substrate binding pocket [chemical binding]; other site 698936010843 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 698936010844 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698936010845 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936010846 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 698936010847 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936010848 catalytic loop [active] 698936010849 iron binding site [ion binding]; other site 698936010850 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698936010851 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 698936010852 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 698936010853 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 698936010854 NAD binding site [chemical binding]; other site 698936010855 homotetramer interface [polypeptide binding]; other site 698936010856 homodimer interface [polypeptide binding]; other site 698936010857 substrate binding site [chemical binding]; other site 698936010858 active site 698936010859 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 698936010860 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 698936010861 N- and C-terminal domain interface [polypeptide binding]; other site 698936010862 active site 698936010863 MgATP binding site [chemical binding]; other site 698936010864 catalytic site [active] 698936010865 metal binding site [ion binding]; metal-binding site 698936010866 glycerol binding site [chemical binding]; other site 698936010867 homotetramer interface [polypeptide binding]; other site 698936010868 homodimer interface [polypeptide binding]; other site 698936010869 FBP binding site [chemical binding]; other site 698936010870 protein IIAGlc interface [polypeptide binding]; other site 698936010871 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936010872 dimerization interface [polypeptide binding]; other site 698936010873 putative DNA binding site [nucleotide binding]; other site 698936010874 putative Zn2+ binding site [ion binding]; other site 698936010875 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 698936010876 putative hydrophobic ligand binding site [chemical binding]; other site 698936010877 Uncharacterized conserved protein [Function unknown]; Region: COG5649 698936010878 Uncharacterized conserved protein [Function unknown]; Region: COG5649 698936010879 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 698936010880 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 698936010881 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698936010882 active site 698936010883 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 698936010884 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698936010885 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 698936010886 Transposase [DNA replication, recombination, and repair]; Region: COG5433 698936010887 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 698936010888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936010889 microcin B17 transporter; Reviewed; Region: PRK11098 698936010890 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 698936010891 NodB motif; other site 698936010892 putative active site [active] 698936010893 putative catalytic site [active] 698936010894 Predicted membrane protein [Function unknown]; Region: COG4094 698936010895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 698936010896 GTP-binding protein Der; Reviewed; Region: PRK00093 698936010897 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698936010898 G1 box; other site 698936010899 GTP/Mg2+ binding site [chemical binding]; other site 698936010900 Switch I region; other site 698936010901 G2 box; other site 698936010902 Switch II region; other site 698936010903 G3 box; other site 698936010904 G4 box; other site 698936010905 G5 box; other site 698936010906 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698936010907 G1 box; other site 698936010908 GTP/Mg2+ binding site [chemical binding]; other site 698936010909 Switch I region; other site 698936010910 G2 box; other site 698936010911 G3 box; other site 698936010912 Switch II region; other site 698936010913 G4 box; other site 698936010914 G5 box; other site 698936010915 Predicted transcriptional regulator [Transcription]; Region: COG1959 698936010916 Transcriptional regulator; Region: Rrf2; pfam02082 698936010917 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 698936010918 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698936010919 active site 698936010920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 698936010921 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698936010922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 698936010923 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698936010924 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698936010925 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 698936010926 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 698936010927 dimer interface [polypeptide binding]; other site 698936010928 active site residues [active] 698936010929 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 698936010930 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698936010931 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698936010932 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 698936010933 nudix motif; other site 698936010934 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 698936010935 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 698936010936 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 698936010937 Uroporphyrinogen-III methylase [Coenzyme metabolism]; Region: CysG; COG0007 698936010938 homodimer interface [polypeptide binding]; other site 698936010939 active site 698936010940 SAM binding site [chemical binding]; other site 698936010941 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 698936010942 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 698936010943 [4Fe-4S] binding site [ion binding]; other site 698936010944 molybdopterin cofactor binding site; other site 698936010945 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 698936010946 molybdopterin cofactor binding site; other site 698936010947 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 698936010948 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 698936010949 [2Fe-2S] cluster binding site [ion binding]; other site 698936010950 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 698936010951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936010952 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 698936010953 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 698936010954 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698936010955 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 698936010956 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 698936010957 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 698936010958 DctM-like transporters; Region: DctM; pfam06808 698936010959 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 698936010960 Acyl dehydratase [Lipid metabolism]; Region: MaoC; COG2030 698936010961 active site 2 [active] 698936010962 active site 1 [active] 698936010963 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936010964 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936010965 DNA binding site [nucleotide binding] 698936010966 domain linker motif; other site 698936010967 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 698936010968 ligand binding site [chemical binding]; other site 698936010969 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698936010970 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936010971 substrate binding pocket [chemical binding]; other site 698936010972 membrane-bound complex binding site; other site 698936010973 hinge residues; other site 698936010974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936010975 dimer interface [polypeptide binding]; other site 698936010976 conserved gate region; other site 698936010977 putative PBP binding loops; other site 698936010978 ABC-ATPase subunit interface; other site 698936010979 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 698936010980 C factor cell-cell signaling protein; Provisional; Region: PRK09009 698936010981 NADP binding site [chemical binding]; other site 698936010982 homodimer interface [polypeptide binding]; other site 698936010983 active site 698936010984 hypothetical protein; Provisional; Region: PRK06148 698936010985 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698936010986 active site 698936010987 ATP binding site [chemical binding]; other site 698936010988 substrate binding site [chemical binding]; other site 698936010989 Peptidase family M23; Region: Peptidase_M23; pfam01551 698936010990 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698936010991 inhibitor-cofactor binding pocket; inhibition site 698936010992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936010993 catalytic residue [active] 698936010994 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936010995 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936010996 Walker A/P-loop; other site 698936010997 ATP binding site [chemical binding]; other site 698936010998 Q-loop/lid; other site 698936010999 ABC transporter signature motif; other site 698936011000 Walker B; other site 698936011001 D-loop; other site 698936011002 H-loop/switch region; other site 698936011003 TOBE domain; Region: TOBE_2; pfam08402 698936011004 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936011005 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936011006 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936011007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011008 dimer interface [polypeptide binding]; other site 698936011009 conserved gate region; other site 698936011010 putative PBP binding loops; other site 698936011011 ABC-ATPase subunit interface; other site 698936011012 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936011013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011014 dimer interface [polypeptide binding]; other site 698936011015 conserved gate region; other site 698936011016 putative PBP binding loops; other site 698936011017 ABC-ATPase subunit interface; other site 698936011018 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 698936011019 Trehalase; Region: Trehalase; cl17346 698936011020 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936011021 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936011022 DNA binding site [nucleotide binding] 698936011023 domain linker motif; other site 698936011024 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 698936011025 ligand binding site [chemical binding]; other site 698936011026 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 698936011027 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 698936011028 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 698936011029 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 698936011030 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698936011031 Beta-lactamase; Region: Beta-lactamase; pfam00144 698936011032 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698936011033 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 698936011034 dimer interface [polypeptide binding]; other site 698936011035 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698936011036 catalytic triad [active] 698936011037 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698936011038 substrate binding site [chemical binding]; other site 698936011039 dimer interface [polypeptide binding]; other site 698936011040 ATP binding site [chemical binding]; other site 698936011041 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 698936011042 Chain length determinant protein; Region: Wzz; pfam02706 698936011043 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 698936011044 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698936011045 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698936011046 active site 698936011047 tetramer interface; other site 698936011048 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698936011049 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698936011050 active site 698936011051 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698936011052 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698936011053 active site 698936011054 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698936011055 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 698936011056 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698936011057 Ligand binding site; other site 698936011058 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698936011059 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 698936011060 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 698936011061 active site 698936011062 active site 698936011063 catalytic residues [active] 698936011064 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698936011065 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 698936011066 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 698936011067 Catalytic site; other site 698936011068 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 698936011069 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 698936011070 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698936011071 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698936011072 active site 698936011073 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 698936011074 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698936011075 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698936011076 active site 698936011077 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698936011078 Exopolysaccharide production repressor; Region: SyrA; pfam11089 698936011079 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 698936011080 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 698936011081 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 698936011082 SLBB domain; Region: SLBB; pfam10531 698936011083 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 698936011084 O-Antigen ligase; Region: Wzy_C; pfam04932 698936011085 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698936011086 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698936011087 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698936011088 NAD binding site [chemical binding]; other site 698936011089 homodimer interface [polypeptide binding]; other site 698936011090 active site 698936011091 substrate binding site [chemical binding]; other site 698936011092 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936011093 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 698936011094 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 698936011095 Walker A/P-loop; other site 698936011096 ATP binding site [chemical binding]; other site 698936011097 Q-loop/lid; other site 698936011098 ABC transporter signature motif; other site 698936011099 Walker B; other site 698936011100 D-loop; other site 698936011101 H-loop/switch region; other site 698936011102 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 698936011103 Ligand Binding Site [chemical binding]; other site 698936011104 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 698936011105 active site 698936011106 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 698936011107 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 698936011108 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 698936011109 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 698936011110 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 698936011111 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698936011112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936011113 non-specific DNA binding site [nucleotide binding]; other site 698936011114 salt bridge; other site 698936011115 sequence-specific DNA binding site [nucleotide binding]; other site 698936011116 Response regulator receiver domain; Region: Response_reg; pfam00072 698936011117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936011118 active site 698936011119 phosphorylation site [posttranslational modification] 698936011120 intermolecular recognition site; other site 698936011121 dimerization interface [polypeptide binding]; other site 698936011122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936011123 PAS domain; Region: PAS_9; pfam13426 698936011124 putative active site [active] 698936011125 heme pocket [chemical binding]; other site 698936011126 PAS domain S-box; Region: sensory_box; TIGR00229 698936011127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936011128 putative active site [active] 698936011129 heme pocket [chemical binding]; other site 698936011130 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 698936011131 GAF domain; Region: GAF; pfam01590 698936011132 PAS fold; Region: PAS_4; pfam08448 698936011133 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936011134 PAS fold; Region: PAS_3; pfam08447 698936011135 putative active site [active] 698936011136 heme pocket [chemical binding]; other site 698936011137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698936011138 HWE histidine kinase; Region: HWE_HK; pfam07536 698936011139 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 698936011140 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 698936011141 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 698936011142 active site 698936011143 catalytic residues [active] 698936011144 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 698936011145 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698936011146 ligand binding site [chemical binding]; other site 698936011147 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698936011148 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936011149 Walker A/P-loop; other site 698936011150 ATP binding site [chemical binding]; other site 698936011151 Q-loop/lid; other site 698936011152 ABC transporter signature motif; other site 698936011153 Walker B; other site 698936011154 D-loop; other site 698936011155 H-loop/switch region; other site 698936011156 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936011157 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936011158 TM-ABC transporter signature motif; other site 698936011159 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 698936011160 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 698936011161 protein binding site [polypeptide binding]; other site 698936011162 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 698936011163 Active site serine [active] 698936011164 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 698936011165 Peptidase family M50; Region: Peptidase_M50; pfam02163 698936011166 active site 698936011167 putative substrate binding region [chemical binding]; other site 698936011168 FOG: CBS domain [General function prediction only]; Region: COG0517 698936011169 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 698936011170 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 698936011171 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 698936011172 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936011173 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936011174 Walker A/P-loop; other site 698936011175 ATP binding site [chemical binding]; other site 698936011176 Q-loop/lid; other site 698936011177 ABC transporter signature motif; other site 698936011178 Walker B; other site 698936011179 D-loop; other site 698936011180 H-loop/switch region; other site 698936011181 TOBE domain; Region: TOBE_2; pfam08402 698936011182 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936011183 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698936011184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011185 dimer interface [polypeptide binding]; other site 698936011186 conserved gate region; other site 698936011187 putative PBP binding loops; other site 698936011188 ABC-ATPase subunit interface; other site 698936011189 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936011190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011191 dimer interface [polypeptide binding]; other site 698936011192 conserved gate region; other site 698936011193 putative PBP binding loops; other site 698936011194 ABC-ATPase subunit interface; other site 698936011195 Predicted transcriptional regulator [Transcription]; Region: COG4189 698936011196 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936011197 putative DNA binding site [nucleotide binding]; other site 698936011198 dimerization interface [polypeptide binding]; other site 698936011199 putative Zn2+ binding site [ion binding]; other site 698936011200 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 698936011201 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698936011202 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936011203 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936011204 DNA binding site [nucleotide binding] 698936011205 domain linker motif; other site 698936011206 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 698936011207 ligand binding site [chemical binding]; other site 698936011208 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936011209 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936011210 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936011211 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 698936011212 DNA interaction; other site 698936011213 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936011214 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936011215 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936011216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011217 dimer interface [polypeptide binding]; other site 698936011218 conserved gate region; other site 698936011219 putative PBP binding loops; other site 698936011220 ABC-ATPase subunit interface; other site 698936011221 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936011222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011223 dimer interface [polypeptide binding]; other site 698936011224 conserved gate region; other site 698936011225 ABC-ATPase subunit interface; other site 698936011226 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936011227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936011228 Walker A/P-loop; other site 698936011229 ATP binding site [chemical binding]; other site 698936011230 Q-loop/lid; other site 698936011231 ABC transporter signature motif; other site 698936011232 Walker B; other site 698936011233 D-loop; other site 698936011234 H-loop/switch region; other site 698936011235 TOBE domain; Region: TOBE; cl01440 698936011236 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936011237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936011238 DNA-binding site [nucleotide binding]; DNA binding site 698936011239 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936011240 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936011241 TM-ABC transporter signature motif; other site 698936011242 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936011243 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936011244 TM-ABC transporter signature motif; other site 698936011245 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936011246 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936011247 Walker A/P-loop; other site 698936011248 ATP binding site [chemical binding]; other site 698936011249 Q-loop/lid; other site 698936011250 ABC transporter signature motif; other site 698936011251 Walker B; other site 698936011252 D-loop; other site 698936011253 H-loop/switch region; other site 698936011254 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936011255 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936011256 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 698936011257 putative ligand binding site [chemical binding]; other site 698936011258 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 698936011259 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 698936011260 putative active site [active] 698936011261 putative NTP binding site [chemical binding]; other site 698936011262 putative nucleic acid binding site [nucleotide binding]; other site 698936011263 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 698936011264 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698936011265 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698936011266 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 698936011267 glutathione synthetase; Provisional; Region: PRK12458 698936011268 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 698936011269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3930 698936011270 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 698936011271 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 698936011272 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 698936011273 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936011274 putative ADP-binding pocket [chemical binding]; other site 698936011275 Predicted membrane protein [Function unknown]; Region: COG1238 698936011276 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 698936011277 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 698936011278 DNA binding residues [nucleotide binding] 698936011279 dimer interface [polypeptide binding]; other site 698936011280 copper binding site [ion binding]; other site 698936011281 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698936011282 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698936011283 metal-binding site [ion binding] 698936011284 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698936011285 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698936011286 metal-binding site [ion binding] 698936011287 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698936011288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936011289 motif II; other site 698936011290 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698936011291 metal-binding site [ion binding] 698936011292 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936011293 dimerization interface [polypeptide binding]; other site 698936011294 putative DNA binding site [nucleotide binding]; other site 698936011295 putative Zn2+ binding site [ion binding]; other site 698936011296 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936011297 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936011298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936011299 ATP binding site [chemical binding]; other site 698936011300 Mg2+ binding site [ion binding]; other site 698936011301 G-X-G motif; other site 698936011302 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 698936011303 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698936011304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698936011305 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698936011306 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 698936011307 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698936011308 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936011309 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936011310 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 698936011311 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 698936011312 putative active site [active] 698936011313 putative FMN binding site [chemical binding]; other site 698936011314 putative substrate binding site [chemical binding]; other site 698936011315 putative catalytic residue [active] 698936011316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698936011317 Cupin domain; Region: Cupin_2; cl17218 698936011318 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 698936011319 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698936011320 oligomerisation interface [polypeptide binding]; other site 698936011321 mobile loop; other site 698936011322 roof hairpin; other site 698936011323 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698936011324 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698936011325 ring oligomerisation interface [polypeptide binding]; other site 698936011326 ATP/Mg binding site [chemical binding]; other site 698936011327 stacking interactions; other site 698936011328 hinge regions; other site 698936011329 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 698936011330 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698936011331 active site 698936011332 catalytic site [active] 698936011333 substrate binding site [chemical binding]; other site 698936011334 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 698936011335 dimer interface [polypeptide binding]; other site 698936011336 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698936011337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936011338 active site 698936011339 phosphorylation site [posttranslational modification] 698936011340 intermolecular recognition site; other site 698936011341 dimerization interface [polypeptide binding]; other site 698936011342 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936011343 DNA binding site [nucleotide binding] 698936011344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936011345 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698936011346 dimerization interface [polypeptide binding]; other site 698936011347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936011348 dimer interface [polypeptide binding]; other site 698936011349 phosphorylation site [posttranslational modification] 698936011350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936011351 ATP binding site [chemical binding]; other site 698936011352 G-X-G motif; other site 698936011353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936011354 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936011355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936011356 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 698936011357 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936011358 catalytic loop [active] 698936011359 iron binding site [ion binding]; other site 698936011360 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698936011361 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 698936011362 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 698936011363 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698936011364 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698936011365 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936011366 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698936011367 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698936011368 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698936011369 TrkA-N domain; Region: TrkA_N; pfam02254 698936011370 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 698936011371 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 698936011372 Sulphur transport; Region: Sulf_transp; pfam04143 698936011373 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698936011374 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698936011375 active site residue [active] 698936011376 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 698936011377 active site residue [active] 698936011378 Autotransporter beta-domain; Region: Autotransporter; pfam03797 698936011379 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 698936011380 Histidine kinase; Region: His_kinase; pfam06580 698936011381 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698936011382 ATP binding site [chemical binding]; other site 698936011383 Mg2+ binding site [ion binding]; other site 698936011384 G-X-G motif; other site 698936011385 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 698936011386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936011387 active site 698936011388 phosphorylation site [posttranslational modification] 698936011389 intermolecular recognition site; other site 698936011390 dimerization interface [polypeptide binding]; other site 698936011391 LytTr DNA-binding domain; Region: LytTR; pfam04397 698936011392 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 698936011393 active site 698936011394 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 698936011395 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 698936011396 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 698936011397 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 698936011398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011399 dimer interface [polypeptide binding]; other site 698936011400 conserved gate region; other site 698936011401 putative PBP binding loops; other site 698936011402 ABC-ATPase subunit interface; other site 698936011403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011404 dimer interface [polypeptide binding]; other site 698936011405 conserved gate region; other site 698936011406 putative PBP binding loops; other site 698936011407 ABC-ATPase subunit interface; other site 698936011408 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 698936011409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936011410 Walker A/P-loop; other site 698936011411 ATP binding site [chemical binding]; other site 698936011412 Q-loop/lid; other site 698936011413 ABC transporter signature motif; other site 698936011414 Walker B; other site 698936011415 D-loop; other site 698936011416 H-loop/switch region; other site 698936011417 TOBE domain; Region: TOBE_2; pfam08402 698936011418 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698936011419 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698936011420 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 698936011421 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 698936011422 NAD(P) binding site [chemical binding]; other site 698936011423 catalytic residues [active] 698936011424 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 698936011425 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 698936011426 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 698936011427 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698936011428 catalytic residue [active] 698936011429 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 698936011430 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 698936011431 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 698936011432 PhoU domain; Region: PhoU; pfam01895 698936011433 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 698936011434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936011435 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698936011436 dimerization interface [polypeptide binding]; other site 698936011437 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936011438 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936011439 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 698936011440 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 698936011441 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698936011442 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698936011443 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698936011444 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936011445 DNA-binding site [nucleotide binding]; DNA binding site 698936011446 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698936011447 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 698936011448 Predicted membrane protein [Function unknown]; Region: COG2855 698936011449 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 698936011450 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698936011451 PYR/PP interface [polypeptide binding]; other site 698936011452 dimer interface [polypeptide binding]; other site 698936011453 TPP binding site [chemical binding]; other site 698936011454 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698936011455 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 698936011456 TPP-binding site; other site 698936011457 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698936011458 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936011459 SnoaL-like domain; Region: SnoaL_2; pfam12680 698936011460 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698936011461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011462 dimer interface [polypeptide binding]; other site 698936011463 conserved gate region; other site 698936011464 putative PBP binding loops; other site 698936011465 ABC-ATPase subunit interface; other site 698936011466 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 698936011467 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698936011468 Walker A/P-loop; other site 698936011469 ATP binding site [chemical binding]; other site 698936011470 Q-loop/lid; other site 698936011471 ABC transporter signature motif; other site 698936011472 Walker B; other site 698936011473 D-loop; other site 698936011474 H-loop/switch region; other site 698936011475 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 698936011476 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936011477 substrate binding pocket [chemical binding]; other site 698936011478 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 698936011479 membrane-bound complex binding site; other site 698936011480 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698936011481 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936011482 DNA-binding site [nucleotide binding]; DNA binding site 698936011483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936011484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936011485 homodimer interface [polypeptide binding]; other site 698936011486 catalytic residue [active] 698936011487 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 698936011488 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936011489 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 698936011490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936011491 NAD(P) binding site [chemical binding]; other site 698936011492 active site 698936011493 short chain dehydrogenase; Provisional; Region: PRK12937 698936011494 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 698936011495 NADP binding site [chemical binding]; other site 698936011496 homodimer interface [polypeptide binding]; other site 698936011497 active site 698936011498 substrate binding site [chemical binding]; other site 698936011499 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 698936011500 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 698936011501 active site 698936011502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 698936011503 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698936011504 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 698936011505 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936011506 putative ligand binding site [chemical binding]; other site 698936011507 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936011508 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936011509 Walker A/P-loop; other site 698936011510 ATP binding site [chemical binding]; other site 698936011511 Q-loop/lid; other site 698936011512 ABC transporter signature motif; other site 698936011513 Walker B; other site 698936011514 D-loop; other site 698936011515 H-loop/switch region; other site 698936011516 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936011517 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936011518 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936011519 TM-ABC transporter signature motif; other site 698936011520 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698936011521 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 698936011522 substrate binding site [chemical binding]; other site 698936011523 ATP binding site [chemical binding]; other site 698936011524 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 698936011525 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936011526 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936011527 DNA binding site [nucleotide binding] 698936011528 domain linker motif; other site 698936011529 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698936011530 dimerization interface [polypeptide binding]; other site 698936011531 ligand binding site [chemical binding]; other site 698936011532 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698936011533 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698936011534 D-pathway; other site 698936011535 Putative ubiquinol binding site [chemical binding]; other site 698936011536 Low-spin heme (heme b) binding site [chemical binding]; other site 698936011537 Putative water exit pathway; other site 698936011538 Binuclear center (heme o3/CuB) [ion binding]; other site 698936011539 K-pathway; other site 698936011540 Putative proton exit pathway; other site 698936011541 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 698936011542 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 698936011543 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 698936011544 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 698936011545 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698936011546 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 698936011547 Cytochrome c; Region: Cytochrom_C; pfam00034 698936011548 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698936011549 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698936011550 Cytochrome c553 [Energy production and conversion]; Region: COG2863 698936011551 Cytochrome c; Region: Cytochrom_C; cl11414 698936011552 Predicted membrane protein [Function unknown]; Region: COG3336 698936011553 Predicted membrane protein [Function unknown]; Region: COG4244 698936011554 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 698936011555 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 698936011556 Predicted membrane protein [Function unknown]; Region: COG2323 698936011557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936011558 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 698936011559 catalytic triad [active] 698936011560 conserved cis-peptide bond; other site 698936011561 Predicted membrane protein [Function unknown]; Region: COG4244 698936011562 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 698936011563 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936011564 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936011565 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936011566 glucuronate isomerase; Reviewed; Region: PRK02925 698936011567 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 698936011568 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 698936011569 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 698936011570 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 698936011571 DctM-like transporters; Region: DctM; pfam06808 698936011572 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 698936011573 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936011574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936011575 DNA-binding site [nucleotide binding]; DNA binding site 698936011576 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698936011577 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 698936011578 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 698936011579 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698936011580 NADP binding site [chemical binding]; other site 698936011581 homodimer interface [polypeptide binding]; other site 698936011582 active site 698936011583 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 698936011584 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936011585 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936011586 DNA binding site [nucleotide binding] 698936011587 domain linker motif; other site 698936011588 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 698936011589 putative dimerization interface [polypeptide binding]; other site 698936011590 putative ligand binding site [chemical binding]; other site 698936011591 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936011592 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 698936011593 putative ligand binding site [chemical binding]; other site 698936011594 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936011595 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936011596 Walker A/P-loop; other site 698936011597 ATP binding site [chemical binding]; other site 698936011598 Q-loop/lid; other site 698936011599 ABC transporter signature motif; other site 698936011600 Walker B; other site 698936011601 D-loop; other site 698936011602 H-loop/switch region; other site 698936011603 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936011604 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936011605 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936011606 TM-ABC transporter signature motif; other site 698936011607 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936011608 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936011609 TM-ABC transporter signature motif; other site 698936011610 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 698936011611 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698936011612 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698936011613 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936011614 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 698936011615 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 698936011616 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 698936011617 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698936011618 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698936011619 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936011620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936011621 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698936011622 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698936011623 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 698936011624 BON domain; Region: BON; cl02771 698936011625 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 698936011626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 698936011627 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 698936011628 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 698936011629 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 698936011630 NADP binding site [chemical binding]; other site 698936011631 active site 698936011632 putative substrate binding site [chemical binding]; other site 698936011633 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 698936011634 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 698936011635 NAD binding site [chemical binding]; other site 698936011636 substrate binding site [chemical binding]; other site 698936011637 homodimer interface [polypeptide binding]; other site 698936011638 active site 698936011639 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 698936011640 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 698936011641 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 698936011642 substrate binding site; other site 698936011643 tetramer interface; other site 698936011644 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 698936011645 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 698936011646 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 698936011647 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 698936011648 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698936011649 active site 698936011650 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936011651 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698936011652 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936011653 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 698936011654 putative ADP-binding pocket [chemical binding]; other site 698936011655 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698936011656 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 698936011657 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 698936011658 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936011659 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 698936011660 Walker A/P-loop; other site 698936011661 ATP binding site [chemical binding]; other site 698936011662 Q-loop/lid; other site 698936011663 ABC transporter signature motif; other site 698936011664 Walker B; other site 698936011665 D-loop; other site 698936011666 H-loop/switch region; other site 698936011667 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 698936011668 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 698936011669 lipoyl-biotinyl attachment site [posttranslational modification]; other site 698936011670 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936011671 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 698936011672 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698936011673 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698936011674 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698936011675 active site 698936011676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936011677 S-adenosylmethionine binding site [chemical binding]; other site 698936011678 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936011679 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 698936011680 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936011681 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 698936011682 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936011683 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698936011684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936011685 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 698936011686 motif I; other site 698936011687 active site 698936011688 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 698936011689 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698936011690 active site 698936011691 metal binding site [ion binding]; metal-binding site 698936011692 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 698936011693 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 698936011694 Sulfatase; Region: Sulfatase; pfam00884 698936011695 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698936011696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936011697 active site 698936011698 phosphorylation site [posttranslational modification] 698936011699 intermolecular recognition site; other site 698936011700 dimerization interface [polypeptide binding]; other site 698936011701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936011702 DNA binding site [nucleotide binding] 698936011703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936011704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936011705 dimer interface [polypeptide binding]; other site 698936011706 phosphorylation site [posttranslational modification] 698936011707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936011708 ATP binding site [chemical binding]; other site 698936011709 Mg2+ binding site [ion binding]; other site 698936011710 G-X-G motif; other site 698936011711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936011712 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 698936011713 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 698936011714 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936011715 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936011716 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698936011717 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698936011718 Walker A/P-loop; other site 698936011719 ATP binding site [chemical binding]; other site 698936011720 Q-loop/lid; other site 698936011721 ABC transporter signature motif; other site 698936011722 Walker B; other site 698936011723 D-loop; other site 698936011724 H-loop/switch region; other site 698936011725 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698936011726 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698936011727 Walker A/P-loop; other site 698936011728 ATP binding site [chemical binding]; other site 698936011729 Q-loop/lid; other site 698936011730 ABC transporter signature motif; other site 698936011731 Walker B; other site 698936011732 D-loop; other site 698936011733 H-loop/switch region; other site 698936011734 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 698936011735 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 698936011736 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 698936011737 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698936011738 Predicted esterase [General function prediction only]; Region: COG0400 698936011739 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 698936011740 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936011741 Zn binding site [ion binding]; other site 698936011742 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 698936011743 Zn binding site [ion binding]; other site 698936011744 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 698936011745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936011746 dimer interface [polypeptide binding]; other site 698936011747 phosphorylation site [posttranslational modification] 698936011748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936011749 ATP binding site [chemical binding]; other site 698936011750 Mg2+ binding site [ion binding]; other site 698936011751 G-X-G motif; other site 698936011752 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 698936011753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936011754 active site 698936011755 phosphorylation site [posttranslational modification] 698936011756 intermolecular recognition site; other site 698936011757 dimerization interface [polypeptide binding]; other site 698936011758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936011759 Walker A motif; other site 698936011760 ATP binding site [chemical binding]; other site 698936011761 Walker B motif; other site 698936011762 arginine finger; other site 698936011763 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 698936011764 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 698936011765 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936011766 Walker A/P-loop; other site 698936011767 ATP binding site [chemical binding]; other site 698936011768 Q-loop/lid; other site 698936011769 ABC transporter signature motif; other site 698936011770 Walker B; other site 698936011771 D-loop; other site 698936011772 H-loop/switch region; other site 698936011773 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698936011774 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936011775 Walker A/P-loop; other site 698936011776 ATP binding site [chemical binding]; other site 698936011777 Q-loop/lid; other site 698936011778 ABC transporter signature motif; other site 698936011779 Walker B; other site 698936011780 D-loop; other site 698936011781 H-loop/switch region; other site 698936011782 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936011783 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 698936011784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011785 dimer interface [polypeptide binding]; other site 698936011786 conserved gate region; other site 698936011787 ABC-ATPase subunit interface; other site 698936011788 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 698936011789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011790 dimer interface [polypeptide binding]; other site 698936011791 conserved gate region; other site 698936011792 putative PBP binding loops; other site 698936011793 ABC-ATPase subunit interface; other site 698936011794 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 698936011795 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 698936011796 peptide binding site [polypeptide binding]; other site 698936011797 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698936011798 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 698936011799 intersubunit interface [polypeptide binding]; other site 698936011800 active site 698936011801 zinc binding site [ion binding]; other site 698936011802 Na+ binding site [ion binding]; other site 698936011803 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936011804 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 698936011805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936011806 Walker A/P-loop; other site 698936011807 ATP binding site [chemical binding]; other site 698936011808 Q-loop/lid; other site 698936011809 ABC transporter signature motif; other site 698936011810 Walker B; other site 698936011811 D-loop; other site 698936011812 H-loop/switch region; other site 698936011813 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698936011814 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 698936011815 active site 698936011816 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698936011817 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698936011818 active site 698936011819 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698936011820 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698936011821 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698936011822 DNA binding residues [nucleotide binding] 698936011823 dimer interface [polypeptide binding]; other site 698936011824 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 698936011825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936011826 non-specific DNA binding site [nucleotide binding]; other site 698936011827 salt bridge; other site 698936011828 sequence-specific DNA binding site [nucleotide binding]; other site 698936011829 Cupin domain; Region: Cupin_2; pfam07883 698936011830 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 698936011831 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698936011832 inhibitor-cofactor binding pocket; inhibition site 698936011833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936011834 catalytic residue [active] 698936011835 succinic semialdehyde dehydrogenase; Region: PLN02278 698936011836 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698936011837 tetramerization interface [polypeptide binding]; other site 698936011838 NAD(P) binding site [chemical binding]; other site 698936011839 catalytic residues [active] 698936011840 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 698936011841 propionate/acetate kinase; Provisional; Region: PRK12379 698936011842 heat shock protein 90; Provisional; Region: PRK05218 698936011843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936011844 ATP binding site [chemical binding]; other site 698936011845 Mg2+ binding site [ion binding]; other site 698936011846 G-X-G motif; other site 698936011847 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 698936011848 CoA-transferase family III; Region: CoA_transf_3; pfam02515 698936011849 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 698936011850 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698936011851 FAD binding site [chemical binding]; other site 698936011852 substrate binding pocket [chemical binding]; other site 698936011853 catalytic base [active] 698936011854 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936011855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936011856 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698936011857 dimerization interface [polypeptide binding]; other site 698936011858 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936011859 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936011860 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 698936011861 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 698936011862 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 698936011863 Walker A/P-loop; other site 698936011864 ATP binding site [chemical binding]; other site 698936011865 Q-loop/lid; other site 698936011866 ABC transporter signature motif; other site 698936011867 Walker B; other site 698936011868 D-loop; other site 698936011869 H-loop/switch region; other site 698936011870 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 698936011871 Transferrin; Region: Transferrin; cl02460 698936011872 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 698936011873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011874 dimer interface [polypeptide binding]; other site 698936011875 conserved gate region; other site 698936011876 ABC-ATPase subunit interface; other site 698936011877 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 698936011878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011879 dimer interface [polypeptide binding]; other site 698936011880 conserved gate region; other site 698936011881 ABC-ATPase subunit interface; other site 698936011882 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 698936011883 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 698936011884 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698936011885 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 698936011886 active site 698936011887 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 698936011888 active site 698936011889 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936011890 putative DNA binding site [nucleotide binding]; other site 698936011891 putative Zn2+ binding site [ion binding]; other site 698936011892 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698936011893 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 698936011894 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 698936011895 putative active site [active] 698936011896 putative NTP binding site [chemical binding]; other site 698936011897 putative nucleic acid binding site [nucleotide binding]; other site 698936011898 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 698936011899 imidazolonepropionase; Validated; Region: PRK09356 698936011900 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 698936011901 active site 698936011902 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 698936011903 active sites [active] 698936011904 tetramer interface [polypeptide binding]; other site 698936011905 N-formylglutamate amidohydrolase; Region: FGase; cl01522 698936011906 urocanate hydratase; Provisional; Region: PRK05414 698936011907 sugar efflux transporter; Region: 2A0120; TIGR00899 698936011908 Uncharacterized conserved protein [Function unknown]; Region: COG5476 698936011909 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 698936011910 MlrC C-terminus; Region: MlrC_C; pfam07171 698936011911 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 698936011912 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 698936011913 active site 698936011914 short chain dehydrogenase; Provisional; Region: PRK07074 698936011915 classical (c) SDRs; Region: SDR_c; cd05233 698936011916 NAD(P) binding site [chemical binding]; other site 698936011917 active site 698936011918 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698936011919 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698936011920 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698936011921 putative active site [active] 698936011922 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698936011923 homotrimer interaction site [polypeptide binding]; other site 698936011924 putative active site [active] 698936011925 Uncharacterized conserved protein [Function unknown]; Region: COG5476 698936011926 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 698936011927 MlrC C-terminus; Region: MlrC_C; pfam07171 698936011928 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698936011929 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936011930 active site 698936011931 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698936011932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936011933 Coenzyme A binding pocket [chemical binding]; other site 698936011934 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936011935 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936011936 Walker A/P-loop; other site 698936011937 ATP binding site [chemical binding]; other site 698936011938 Q-loop/lid; other site 698936011939 ABC transporter signature motif; other site 698936011940 Walker B; other site 698936011941 D-loop; other site 698936011942 H-loop/switch region; other site 698936011943 TOBE domain; Region: TOBE_2; pfam08402 698936011944 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936011945 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698936011946 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936011947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011948 dimer interface [polypeptide binding]; other site 698936011949 conserved gate region; other site 698936011950 putative PBP binding loops; other site 698936011951 ABC-ATPase subunit interface; other site 698936011952 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936011953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011954 dimer interface [polypeptide binding]; other site 698936011955 conserved gate region; other site 698936011956 putative PBP binding loops; other site 698936011957 ABC-ATPase subunit interface; other site 698936011958 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936011959 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936011960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011961 dimer interface [polypeptide binding]; other site 698936011962 conserved gate region; other site 698936011963 putative PBP binding loops; other site 698936011964 ABC-ATPase subunit interface; other site 698936011965 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 698936011966 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936011967 Walker A/P-loop; other site 698936011968 ATP binding site [chemical binding]; other site 698936011969 Q-loop/lid; other site 698936011970 ABC transporter signature motif; other site 698936011971 Walker B; other site 698936011972 D-loop; other site 698936011973 H-loop/switch region; other site 698936011974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936011975 dimer interface [polypeptide binding]; other site 698936011976 conserved gate region; other site 698936011977 ABC-ATPase subunit interface; other site 698936011978 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698936011979 mercuric reductase; Validated; Region: PRK06370 698936011980 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698936011981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936011982 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698936011983 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 698936011984 Amidinotransferase; Region: Amidinotransf; cl12043 698936011985 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 698936011986 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 698936011987 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698936011988 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698936011989 NAD(P) binding site [chemical binding]; other site 698936011990 catalytic residues [active] 698936011991 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698936011992 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 698936011993 NAD(P) binding site [chemical binding]; other site 698936011994 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698936011995 intersubunit interface [polypeptide binding]; other site 698936011996 active site 698936011997 catalytic residue [active] 698936011998 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 698936011999 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698936012000 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698936012001 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 698936012002 putative binding site; other site 698936012003 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 698936012004 MG2 domain; Region: A2M_N; pfam01835 698936012005 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 698936012006 surface patch; other site 698936012007 thioester region; other site 698936012008 specificity defining residues; other site 698936012009 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 698936012010 Transglycosylase; Region: Transgly; pfam00912 698936012011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698936012012 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 698936012013 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698936012014 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 698936012015 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 698936012016 putative dimer interface [polypeptide binding]; other site 698936012017 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 698936012018 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 698936012019 putative dimer interface [polypeptide binding]; other site 698936012020 guanine deaminase; Provisional; Region: PRK09228 698936012021 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 698936012022 active site 698936012023 Predicted membrane protein [Function unknown]; Region: COG3748 698936012024 Protein of unknown function (DUF989); Region: DUF989; pfam06181 698936012025 Cytochrome c; Region: Cytochrom_C; pfam00034 698936012026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936012027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936012028 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698936012029 putative effector binding pocket; other site 698936012030 dimerization interface [polypeptide binding]; other site 698936012031 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698936012032 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698936012033 NAD(P) binding site [chemical binding]; other site 698936012034 Predicted transcriptional regulators [Transcription]; Region: COG1733 698936012035 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 698936012036 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 698936012037 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 698936012038 XdhC Rossmann domain; Region: XdhC_C; pfam13478 698936012039 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 698936012040 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698936012041 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936012042 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 698936012043 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936012044 catalytic loop [active] 698936012045 iron binding site [ion binding]; other site 698936012046 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698936012047 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 698936012048 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 698936012049 active site 698936012050 homotetramer interface [polypeptide binding]; other site 698936012051 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 698936012052 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 698936012053 active site 698936012054 catalytic site [active] 698936012055 tetramer interface [polypeptide binding]; other site 698936012056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 698936012057 Allantoicase [Nucleotide transport and metabolism]; Region: Alc; COG4266 698936012058 Allantoicase repeat; Region: Allantoicase; pfam03561 698936012059 Allantoicase repeat; Region: Allantoicase; pfam03561 698936012060 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 698936012061 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698936012062 phosphoribosyltransferase; Provisional; Region: PRK06031 698936012063 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698936012064 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 698936012065 metal binding site [ion binding]; metal-binding site 698936012066 putative dimer interface [polypeptide binding]; other site 698936012067 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 698936012068 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698936012069 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 698936012070 active site 698936012071 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 698936012072 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698936012073 active site 698936012074 tetramer interface [polypeptide binding]; other site 698936012075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936012076 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 698936012077 Walker A/P-loop; other site 698936012078 ATP binding site [chemical binding]; other site 698936012079 Q-loop/lid; other site 698936012080 ABC transporter signature motif; other site 698936012081 Walker B; other site 698936012082 D-loop; other site 698936012083 H-loop/switch region; other site 698936012084 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936012085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012086 dimer interface [polypeptide binding]; other site 698936012087 conserved gate region; other site 698936012088 putative PBP binding loops; other site 698936012089 ABC-ATPase subunit interface; other site 698936012090 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 698936012091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012092 dimer interface [polypeptide binding]; other site 698936012093 conserved gate region; other site 698936012094 putative PBP binding loops; other site 698936012095 ABC-ATPase subunit interface; other site 698936012096 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698936012097 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698936012098 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936012099 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936012100 DNA binding site [nucleotide binding] 698936012101 domain linker motif; other site 698936012102 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698936012103 dimerization interface [polypeptide binding]; other site 698936012104 ligand binding site [chemical binding]; other site 698936012105 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 698936012106 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698936012107 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698936012108 ligand binding site [chemical binding]; other site 698936012109 flexible hinge region; other site 698936012110 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936012111 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698936012112 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698936012113 Walker A/P-loop; other site 698936012114 ATP binding site [chemical binding]; other site 698936012115 Q-loop/lid; other site 698936012116 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698936012117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936012118 ABC transporter signature motif; other site 698936012119 Walker B; other site 698936012120 D-loop; other site 698936012121 H-loop/switch region; other site 698936012122 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 698936012123 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698936012124 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 698936012125 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936012126 putative ADP-binding pocket [chemical binding]; other site 698936012127 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 698936012128 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 698936012129 microcin C ABC transporter permease; Provisional; Region: PRK15021 698936012130 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 698936012131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012132 dimer interface [polypeptide binding]; other site 698936012133 conserved gate region; other site 698936012134 putative PBP binding loops; other site 698936012135 ABC-ATPase subunit interface; other site 698936012136 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936012137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012138 dimer interface [polypeptide binding]; other site 698936012139 conserved gate region; other site 698936012140 putative PBP binding loops; other site 698936012141 ABC-ATPase subunit interface; other site 698936012142 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 698936012143 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698936012144 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698936012145 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936012146 Walker A/P-loop; other site 698936012147 ATP binding site [chemical binding]; other site 698936012148 Q-loop/lid; other site 698936012149 ABC transporter signature motif; other site 698936012150 Walker B; other site 698936012151 D-loop; other site 698936012152 H-loop/switch region; other site 698936012153 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936012154 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936012155 Walker A/P-loop; other site 698936012156 ATP binding site [chemical binding]; other site 698936012157 Q-loop/lid; other site 698936012158 ABC transporter signature motif; other site 698936012159 Walker B; other site 698936012160 D-loop; other site 698936012161 H-loop/switch region; other site 698936012162 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936012163 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 698936012164 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936012165 cyclase homology domain; Region: CHD; cd07302 698936012166 nucleotidyl binding site; other site 698936012167 metal binding site [ion binding]; metal-binding site 698936012168 dimer interface [polypeptide binding]; other site 698936012169 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 698936012170 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 698936012171 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698936012172 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 698936012173 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 698936012174 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 698936012175 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 698936012176 NodB motif; other site 698936012177 putative active site [active] 698936012178 putative catalytic site [active] 698936012179 putative Zn binding site [ion binding]; other site 698936012180 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936012181 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698936012182 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698936012183 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698936012184 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936012185 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 698936012186 putative ADP-binding pocket [chemical binding]; other site 698936012187 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 698936012188 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 698936012189 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 698936012190 inhibitor-cofactor binding pocket; inhibition site 698936012191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936012192 catalytic residue [active] 698936012193 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 698936012194 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 698936012195 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 698936012196 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 698936012197 SLBB domain; Region: SLBB; pfam10531 698936012198 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 698936012199 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 698936012200 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 698936012201 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 698936012202 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698936012203 Chain length determinant protein; Region: Wzz; pfam02706 698936012204 Chain length determinant protein; Region: Wzz; cl15801 698936012205 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 698936012206 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 698936012207 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 698936012208 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651 698936012209 putative active site [active] 698936012210 putative substrate binding site [chemical binding]; other site 698936012211 putative cosubstrate binding site; other site 698936012212 catalytic site [active] 698936012213 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 698936012214 active site 698936012215 hexamer interface [polypeptide binding]; other site 698936012216 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 698936012217 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 698936012218 NAD(P) binding site [chemical binding]; other site 698936012219 homodimer interface [polypeptide binding]; other site 698936012220 substrate binding site [chemical binding]; other site 698936012221 active site 698936012222 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 698936012223 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936012224 putative ADP-binding pocket [chemical binding]; other site 698936012225 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936012226 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 698936012227 putative ADP-binding pocket [chemical binding]; other site 698936012228 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 698936012229 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936012230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936012231 NAD(P) binding site [chemical binding]; other site 698936012232 active site 698936012233 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 698936012234 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 698936012235 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 698936012236 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 698936012237 active site 698936012238 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698936012239 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698936012240 active site 698936012241 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 698936012242 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 698936012243 CysD dimerization site [polypeptide binding]; other site 698936012244 G1 box; other site 698936012245 putative GEF interaction site [polypeptide binding]; other site 698936012246 GTP/Mg2+ binding site [chemical binding]; other site 698936012247 Switch I region; other site 698936012248 G2 box; other site 698936012249 G3 box; other site 698936012250 Switch II region; other site 698936012251 G4 box; other site 698936012252 G5 box; other site 698936012253 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 698936012254 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 698936012255 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 698936012256 ligand-binding site [chemical binding]; other site 698936012257 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 698936012258 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 698936012259 Active Sites [active] 698936012260 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698936012261 non-specific DNA interactions [nucleotide binding]; other site 698936012262 DNA binding site [nucleotide binding] 698936012263 sequence specific DNA binding site [nucleotide binding]; other site 698936012264 putative cAMP binding site [chemical binding]; other site 698936012265 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698936012266 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698936012267 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936012268 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936012269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012270 dimer interface [polypeptide binding]; other site 698936012271 conserved gate region; other site 698936012272 putative PBP binding loops; other site 698936012273 ABC-ATPase subunit interface; other site 698936012274 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936012275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012276 dimer interface [polypeptide binding]; other site 698936012277 conserved gate region; other site 698936012278 putative PBP binding loops; other site 698936012279 ABC-ATPase subunit interface; other site 698936012280 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 698936012281 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 698936012282 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 698936012283 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698936012284 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 698936012285 substrate binding site [chemical binding]; other site 698936012286 ATP binding site [chemical binding]; other site 698936012287 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936012288 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936012289 Walker A/P-loop; other site 698936012290 ATP binding site [chemical binding]; other site 698936012291 Q-loop/lid; other site 698936012292 ABC transporter signature motif; other site 698936012293 Walker B; other site 698936012294 D-loop; other site 698936012295 H-loop/switch region; other site 698936012296 TOBE domain; Region: TOBE_2; pfam08402 698936012297 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698936012298 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 698936012299 Bacterial transcriptional regulator; Region: IclR; pfam01614 698936012300 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698936012301 homotrimer interaction site [polypeptide binding]; other site 698936012302 putative active site [active] 698936012303 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698936012304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936012305 Walker A/P-loop; other site 698936012306 ATP binding site [chemical binding]; other site 698936012307 Q-loop/lid; other site 698936012308 ABC transporter signature motif; other site 698936012309 Walker B; other site 698936012310 D-loop; other site 698936012311 H-loop/switch region; other site 698936012312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012313 dimer interface [polypeptide binding]; other site 698936012314 conserved gate region; other site 698936012315 putative PBP binding loops; other site 698936012316 ABC-ATPase subunit interface; other site 698936012317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012318 dimer interface [polypeptide binding]; other site 698936012319 conserved gate region; other site 698936012320 putative PBP binding loops; other site 698936012321 ABC-ATPase subunit interface; other site 698936012322 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698936012323 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936012324 substrate binding pocket [chemical binding]; other site 698936012325 membrane-bound complex binding site; other site 698936012326 hinge residues; other site 698936012327 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 698936012328 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 698936012329 dimer interface [polypeptide binding]; other site 698936012330 active site 698936012331 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698936012332 substrate binding site [chemical binding]; other site 698936012333 catalytic residue [active] 698936012334 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 698936012335 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 698936012336 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698936012337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012338 dimer interface [polypeptide binding]; other site 698936012339 conserved gate region; other site 698936012340 putative PBP binding loops; other site 698936012341 ABC-ATPase subunit interface; other site 698936012342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012343 dimer interface [polypeptide binding]; other site 698936012344 conserved gate region; other site 698936012345 putative PBP binding loops; other site 698936012346 ABC-ATPase subunit interface; other site 698936012347 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 698936012348 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 698936012349 Walker A/P-loop; other site 698936012350 ATP binding site [chemical binding]; other site 698936012351 Q-loop/lid; other site 698936012352 ABC transporter signature motif; other site 698936012353 Walker B; other site 698936012354 D-loop; other site 698936012355 H-loop/switch region; other site 698936012356 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698936012357 FAD binding domain; Region: FAD_binding_4; pfam01565 698936012358 Uncharacterized conserved protein [Function unknown]; Region: COG5654 698936012359 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 698936012360 enoyl-CoA hydratase; Provisional; Region: PRK07468 698936012361 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698936012362 substrate binding site [chemical binding]; other site 698936012363 oxyanion hole (OAH) forming residues; other site 698936012364 trimer interface [polypeptide binding]; other site 698936012365 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 698936012366 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 698936012367 active site 698936012368 catalytic residues [active] 698936012369 metal binding site [ion binding]; metal-binding site 698936012370 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698936012371 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698936012372 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698936012373 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698936012374 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698936012375 carboxyltransferase (CT) interaction site; other site 698936012376 biotinylation site [posttranslational modification]; other site 698936012377 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698936012378 homotrimer interaction site [polypeptide binding]; other site 698936012379 putative active site [active] 698936012380 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 698936012381 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698936012382 isovaleryl-CoA dehydrogenase; Region: PLN02519 698936012383 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698936012384 active site 698936012385 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698936012386 Shikimate kinase; Region: SKI; pfam01202 698936012387 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698936012388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936012389 non-specific DNA binding site [nucleotide binding]; other site 698936012390 salt bridge; other site 698936012391 sequence-specific DNA binding site [nucleotide binding]; other site 698936012392 Uncharacterized conserved protein [Function unknown]; Region: COG3482 698936012393 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 698936012394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936012395 active site 698936012396 phosphorylation site [posttranslational modification] 698936012397 intermolecular recognition site; other site 698936012398 ANTAR domain; Region: ANTAR; pfam03861 698936012399 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 698936012400 NMT1-like family; Region: NMT1_2; pfam13379 698936012401 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 698936012402 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 698936012403 putative active site pocket [active] 698936012404 metal binding site [ion binding]; metal-binding site 698936012405 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698936012406 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698936012407 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936012408 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 698936012409 NAD binding site [chemical binding]; other site 698936012410 homotetramer interface [polypeptide binding]; other site 698936012411 homodimer interface [polypeptide binding]; other site 698936012412 active site 698936012413 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698936012414 active site 2 [active] 698936012415 active site 1 [active] 698936012416 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936012417 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936012418 Uncharacterized conserved protein [Function unknown]; Region: COG3254 698936012419 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 698936012420 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 698936012421 active site pocket [active] 698936012422 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936012423 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936012424 Walker A/P-loop; other site 698936012425 ATP binding site [chemical binding]; other site 698936012426 Q-loop/lid; other site 698936012427 ABC transporter signature motif; other site 698936012428 Walker B; other site 698936012429 D-loop; other site 698936012430 H-loop/switch region; other site 698936012431 TOBE domain; Region: TOBE_2; pfam08402 698936012432 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936012433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012434 dimer interface [polypeptide binding]; other site 698936012435 conserved gate region; other site 698936012436 putative PBP binding loops; other site 698936012437 ABC-ATPase subunit interface; other site 698936012438 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936012439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012440 dimer interface [polypeptide binding]; other site 698936012441 conserved gate region; other site 698936012442 putative PBP binding loops; other site 698936012443 ABC-ATPase subunit interface; other site 698936012444 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936012445 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936012446 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698936012447 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 698936012448 Bacterial transcriptional regulator; Region: IclR; pfam01614 698936012449 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 698936012450 Amidohydrolase; Region: Amidohydro_2; pfam04909 698936012451 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 698936012452 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 698936012453 active site 698936012454 catalytic site [active] 698936012455 Zn binding site [ion binding]; other site 698936012456 tetramer interface [polypeptide binding]; other site 698936012457 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 698936012458 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698936012459 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936012460 substrate binding pocket [chemical binding]; other site 698936012461 membrane-bound complex binding site; other site 698936012462 hinge residues; other site 698936012463 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698936012464 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698936012465 Walker A/P-loop; other site 698936012466 ATP binding site [chemical binding]; other site 698936012467 Q-loop/lid; other site 698936012468 ABC transporter signature motif; other site 698936012469 Walker B; other site 698936012470 D-loop; other site 698936012471 H-loop/switch region; other site 698936012472 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936012473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012474 dimer interface [polypeptide binding]; other site 698936012475 conserved gate region; other site 698936012476 putative PBP binding loops; other site 698936012477 ABC-ATPase subunit interface; other site 698936012478 argininosuccinate lyase; Provisional; Region: PRK00855 698936012479 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698936012480 active sites [active] 698936012481 tetramer interface [polypeptide binding]; other site 698936012482 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698936012483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936012484 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936012485 dimerization interface [polypeptide binding]; other site 698936012486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936012487 Coenzyme A binding pocket [chemical binding]; other site 698936012488 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 698936012489 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 698936012490 active site 698936012491 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936012492 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 698936012493 CoA-transferase family III; Region: CoA_transf_3; pfam02515 698936012494 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 698936012495 MobA/MobL family; Region: MobA_MobL; pfam03389 698936012496 AAA domain; Region: AAA_30; pfam13604 698936012497 Family description; Region: UvrD_C_2; pfam13538 698936012498 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 698936012499 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 698936012500 Substrate binding site; other site 698936012501 Cupin domain; Region: Cupin_2; cl17218 698936012502 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 698936012503 dimerization interface [polypeptide binding]; other site 698936012504 putative active cleft [active] 698936012505 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 698936012506 active site 698936012507 substrate binding site [chemical binding]; other site 698936012508 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 698936012509 metal binding site [ion binding]; metal-binding site 698936012510 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936012511 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936012512 DNA binding residues [nucleotide binding] 698936012513 dimerization interface [polypeptide binding]; other site 698936012514 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698936012515 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698936012516 ligand binding site [chemical binding]; other site 698936012517 flexible hinge region; other site 698936012518 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 698936012519 putative switch regulator; other site 698936012520 non-specific DNA interactions [nucleotide binding]; other site 698936012521 DNA binding site [nucleotide binding] 698936012522 sequence specific DNA binding site [nucleotide binding]; other site 698936012523 putative cAMP binding site [chemical binding]; other site 698936012524 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936012525 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 698936012526 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 698936012527 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936012528 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 698936012529 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936012530 putative ADP-binding pocket [chemical binding]; other site 698936012531 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698936012532 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 698936012533 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 698936012534 Bacterial sugar transferase; Region: Bac_transf; pfam02397 698936012535 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 698936012536 AAA domain; Region: AAA_31; pfam13614 698936012537 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698936012538 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 698936012539 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 698936012540 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 698936012541 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 698936012542 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698936012543 active site 698936012544 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698936012545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936012546 S-adenosylmethionine binding site [chemical binding]; other site 698936012547 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 698936012548 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698936012549 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698936012550 active site 698936012551 Protein of unknown function (DUF707); Region: DUF707; pfam05212 698936012552 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698936012553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936012554 S-adenosylmethionine binding site [chemical binding]; other site 698936012555 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 698936012556 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 698936012557 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698936012558 Methyltransferase domain; Region: Methyltransf_12; pfam08242 698936012559 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 698936012560 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 698936012561 extended (e) SDRs; Region: SDR_e; cd08946 698936012562 NAD(P) binding site [chemical binding]; other site 698936012563 active site 698936012564 substrate binding site [chemical binding]; other site 698936012565 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698936012566 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 698936012567 substrate binding site; other site 698936012568 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 698936012569 Family description; Region: VCBS; pfam13517 698936012570 Family description; Region: VCBS; pfam13517 698936012571 Family description; Region: VCBS; pfam13517 698936012572 Family description; Region: VCBS; pfam13517 698936012573 Family description; Region: VCBS; pfam13517 698936012574 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 698936012575 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698936012576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936012577 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936012578 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698936012579 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936012580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936012581 NAD(P) binding site [chemical binding]; other site 698936012582 active site 698936012583 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 698936012584 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698936012585 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698936012586 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 698936012587 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 698936012588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936012589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 698936012590 active site 698936012591 phosphorylation site [posttranslational modification] 698936012592 intermolecular recognition site; other site 698936012593 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936012594 DNA binding residues [nucleotide binding] 698936012595 dimerization interface [polypeptide binding]; other site 698936012596 acyl carrier protein; Provisional; Region: acpP; PRK00982 698936012597 GXWXG protein; Region: GXWXG; pfam14231 698936012598 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 698936012599 Staphylococcal nuclease homologues; Region: SNc; smart00318 698936012600 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 698936012601 Catalytic site; other site 698936012602 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 698936012603 active site 698936012604 DNA binding site [nucleotide binding] 698936012605 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 698936012606 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 698936012607 DNA binding site [nucleotide binding] 698936012608 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 698936012609 nucleotide binding site [chemical binding]; other site 698936012610 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 698936012611 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 698936012612 metal binding site [ion binding]; metal-binding site 698936012613 dimer interface [polypeptide binding]; other site 698936012614 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 698936012615 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 698936012616 putative active site [active] 698936012617 putative metal binding site [ion binding]; other site 698936012618 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 698936012619 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698936012620 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936012621 Walker A/P-loop; other site 698936012622 ATP binding site [chemical binding]; other site 698936012623 Q-loop/lid; other site 698936012624 ABC transporter signature motif; other site 698936012625 Walker B; other site 698936012626 D-loop; other site 698936012627 H-loop/switch region; other site 698936012628 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936012629 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936012630 Walker A/P-loop; other site 698936012631 ATP binding site [chemical binding]; other site 698936012632 Q-loop/lid; other site 698936012633 ABC transporter signature motif; other site 698936012634 Walker B; other site 698936012635 D-loop; other site 698936012636 H-loop/switch region; other site 698936012637 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698936012638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012639 dimer interface [polypeptide binding]; other site 698936012640 conserved gate region; other site 698936012641 putative PBP binding loops; other site 698936012642 ABC-ATPase subunit interface; other site 698936012643 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936012644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936012645 dimer interface [polypeptide binding]; other site 698936012646 conserved gate region; other site 698936012647 putative PBP binding loops; other site 698936012648 ABC-ATPase subunit interface; other site 698936012649 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936012650 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 698936012651 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698936012652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936012653 non-specific DNA binding site [nucleotide binding]; other site 698936012654 salt bridge; other site 698936012655 sequence-specific DNA binding site [nucleotide binding]; other site 698936012656 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 698936012657 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 698936012658 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 698936012659 putative N- and C-terminal domain interface [polypeptide binding]; other site 698936012660 putative active site [active] 698936012661 putative MgATP binding site [chemical binding]; other site 698936012662 catalytic site [active] 698936012663 metal binding site [ion binding]; metal-binding site 698936012664 putative carbohydrate binding site [chemical binding]; other site 698936012665 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698936012666 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698936012667 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 698936012668 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698936012669 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 698936012670 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936012671 Walker A/P-loop; other site 698936012672 ATP binding site [chemical binding]; other site 698936012673 Q-loop/lid; other site 698936012674 ABC transporter signature motif; other site 698936012675 Walker B; other site 698936012676 D-loop; other site 698936012677 H-loop/switch region; other site 698936012678 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936012679 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936012680 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936012681 TM-ABC transporter signature motif; other site 698936012682 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936012683 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936012684 TM-ABC transporter signature motif; other site 698936012685 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 698936012686 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698936012687 Uncharacterized conserved protein [Function unknown]; Region: COG3347 698936012688 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 698936012689 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 698936012690 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698936012691 dimer interface [polypeptide binding]; other site 698936012692 substrate binding site [chemical binding]; other site 698936012693 metal binding site [ion binding]; metal-binding site 698936012694 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 698936012695 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 698936012696 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 698936012697 Acid Phosphatase; Region: Acid_PPase; cl17256 698936012698 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 698936012699 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 698936012700 active site 698936012701 NTP binding site [chemical binding]; other site 698936012702 metal binding triad [ion binding]; metal-binding site 698936012703 antibiotic binding site [chemical binding]; other site 698936012704 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748 698936012705 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 698936012706 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698936012707 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698936012708 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698936012709 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698936012710 Walker A/P-loop; other site 698936012711 ATP binding site [chemical binding]; other site 698936012712 Q-loop/lid; other site 698936012713 ABC transporter signature motif; other site 698936012714 Walker B; other site 698936012715 D-loop; other site 698936012716 H-loop/switch region; other site 698936012717 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 698936012718 KpsF/GutQ family protein; Region: kpsF; TIGR00393 698936012719 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 698936012720 putative active site [active] 698936012721 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 698936012722 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 698936012723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698936012724 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 698936012725 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698936012726 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 698936012727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698936012728 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 698936012729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698936012730 Transposase; Region: HTH_Tnp_1; pfam01527 698936012731 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 698936012732 Right handed beta helix region; Region: Beta_helix; pfam13229 698936012733 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 698936012734 trimer interface [polypeptide binding]; other site 698936012735 active site 698936012736 substrate binding site [chemical binding]; other site 698936012737 CoA binding site [chemical binding]; other site 698936012738 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 698936012739 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 698936012740 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698936012741 active site 698936012742 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 698936012743 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 698936012744 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698936012745 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698936012746 Ketopantoate hydroxymethyltransferase [Coenzyme metabolism]; Region: PanB; COG0413 698936012747 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 698936012748 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936012749 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 698936012750 [2Fe-2S] cluster binding site [ion binding]; other site 698936012751 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698936012752 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 698936012753 putative di-iron ligands [ion binding]; other site 698936012754 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936012755 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936012756 DNA binding site [nucleotide binding] 698936012757 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 698936012758 putative ligand binding site [chemical binding]; other site 698936012759 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 698936012760 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 698936012761 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 698936012762 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 698936012763 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 698936012764 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698936012765 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936012766 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 698936012767 Walker A/P-loop; other site 698936012768 ATP binding site [chemical binding]; other site 698936012769 Q-loop/lid; other site 698936012770 ABC transporter signature motif; other site 698936012771 Walker B; other site 698936012772 D-loop; other site 698936012773 H-loop/switch region; other site 698936012774 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 698936012775 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698936012776 KpsF/GutQ family protein; Region: kpsF; TIGR00393 698936012777 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 698936012778 putative active site [active] 698936012779 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 698936012780 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 698936012781 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 698936012782 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698936012783 active site 698936012784 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698936012785 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698936012786 active site 698936012787 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 698936012788 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 698936012789 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698936012790 metal-binding site [ion binding] 698936012791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 698936012792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4333 698936012793 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698936012794 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698936012795 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698936012796 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698936012797 GcrA cell cycle regulator; Region: GcrA; cl11564 698936012798 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698936012799 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936012800 cyclase homology domain; Region: CHD; cd07302 698936012801 nucleotidyl binding site; other site 698936012802 metal binding site [ion binding]; metal-binding site 698936012803 dimer interface [polypeptide binding]; other site 698936012804 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936012805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936012806 TPR motif; other site 698936012807 TPR repeat; Region: TPR_11; pfam13414 698936012808 binding surface 698936012809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936012810 binding surface 698936012811 TPR motif; other site 698936012812 Ribosomal_L32_L32e: L32 is a protein from the large subunit that contains a surface-exposed globular domain and a finger-like projection that extends into the RNA core to stabilize the tertiary structure. L32 does not appear to play a role in forming the...; Region: Ribosomal_L32_L32e; cl00748 698936012813 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936012814 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936012815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936012816 DNA binding site [nucleotide binding] 698936012817 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936012818 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698936012819 ligand binding site [chemical binding]; other site 698936012820 dimerization interface [polypeptide binding]; other site 698936012821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289 698936012822 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 698936012823 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698936012824 putative ligand binding site [chemical binding]; other site 698936012825 putative NAD binding site [chemical binding]; other site 698936012826 catalytic site [active] 698936012827 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 698936012828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 698936012829 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 698936012830 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698936012831 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 698936012832 RNA polymerase sigma factor; Provisional; Region: PRK12512 698936012833 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698936012834 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936012835 DNA binding residues [nucleotide binding] 698936012836 Predicted integral membrane protein [Function unknown]; Region: COG5572 698936012837 hypothetical protein; Provisional; Region: PRK05409 698936012838 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 698936012839 YCII-related domain; Region: YCII; cl00999 698936012840 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936012841 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936012842 metal binding site [ion binding]; metal-binding site 698936012843 active site 698936012844 I-site; other site 698936012845 PRC-barrel domain; Region: PRC; pfam05239 698936012846 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 698936012847 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698936012848 response regulator; Provisional; Region: PRK13435 698936012849 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 698936012850 CheB methylesterase; Region: CheB_methylest; pfam01339 698936012851 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 698936012852 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 698936012853 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 698936012854 PAS domain; Region: PAS_10; pfam13596 698936012855 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936012856 putative active site [active] 698936012857 heme pocket [chemical binding]; other site 698936012858 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936012859 PAS domain; Region: PAS_9; pfam13426 698936012860 putative active site [active] 698936012861 heme pocket [chemical binding]; other site 698936012862 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698936012863 HWE histidine kinase; Region: HWE_HK; pfam07536 698936012864 CheB methylesterase; Region: CheB_methylest; pfam01339 698936012865 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 698936012866 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 698936012867 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 698936012868 putative active site [active] 698936012869 short chain dehydrogenase; Provisional; Region: PRK07063 698936012870 classical (c) SDRs; Region: SDR_c; cd05233 698936012871 NAD(P) binding site [chemical binding]; other site 698936012872 active site 698936012873 galactonate dehydratase; Provisional; Region: PRK14017 698936012874 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 698936012875 putative active site pocket [active] 698936012876 putative metal binding site [ion binding]; other site 698936012877 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936012878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936012879 DNA-binding site [nucleotide binding]; DNA binding site 698936012880 FCD domain; Region: FCD; pfam07729 698936012881 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 698936012882 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 698936012883 ligand binding site [chemical binding]; other site 698936012884 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 698936012885 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936012886 Walker A/P-loop; other site 698936012887 ATP binding site [chemical binding]; other site 698936012888 Q-loop/lid; other site 698936012889 ABC transporter signature motif; other site 698936012890 Walker B; other site 698936012891 D-loop; other site 698936012892 H-loop/switch region; other site 698936012893 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936012894 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936012895 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936012896 TM-ABC transporter signature motif; other site 698936012897 Phosphotransferase enzyme family; Region: APH; pfam01636 698936012898 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698936012899 active site 698936012900 ATP binding site [chemical binding]; other site 698936012901 substrate binding site [chemical binding]; other site 698936012902 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936012903 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 698936012904 ligand binding site [chemical binding]; other site 698936012905 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936012906 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936012907 Walker A/P-loop; other site 698936012908 ATP binding site [chemical binding]; other site 698936012909 Q-loop/lid; other site 698936012910 ABC transporter signature motif; other site 698936012911 Walker B; other site 698936012912 D-loop; other site 698936012913 H-loop/switch region; other site 698936012914 Methyl-coenzyme M reductase (MCR) gamma subunit. MCR catalyzes the terminal step of methane formation in the energy metabolism of all methanogenic archaea, in which methyl-coenzyme M and coenzyme B are converted to methane and the heterodisulfide of...; Region: MCR_gamma; cl00247 698936012915 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936012916 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936012917 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936012918 TM-ABC transporter signature motif; other site 698936012919 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698936012920 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936012921 DNA binding residues [nucleotide binding] 698936012922 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698936012923 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936012924 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936012925 active site 698936012926 catalytic tetrad [active] 698936012927 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698936012928 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698936012929 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 698936012930 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 698936012931 putative active site; other site 698936012932 catalytic residue [active] 698936012933 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698936012934 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 698936012935 putative N- and C-terminal domain interface [polypeptide binding]; other site 698936012936 putative active site [active] 698936012937 MgATP binding site [chemical binding]; other site 698936012938 catalytic site [active] 698936012939 metal binding site [ion binding]; metal-binding site 698936012940 putative xylulose binding site [chemical binding]; other site 698936012941 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698936012942 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 698936012943 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698936012944 TPR repeat; Region: TPR_11; pfam13414 698936012945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 698936012946 TPR motif; other site 698936012947 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 698936012948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936012949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936012950 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 698936012951 putative effector binding pocket; other site 698936012952 putative dimerization interface [polypeptide binding]; other site 698936012953 short chain dehydrogenase; Provisional; Region: PRK12937 698936012954 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 698936012955 NADP binding site [chemical binding]; other site 698936012956 homodimer interface [polypeptide binding]; other site 698936012957 active site 698936012958 substrate binding site [chemical binding]; other site 698936012959 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698936012960 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 698936012961 NADP binding site [chemical binding]; other site 698936012962 active site 698936012963 steroid binding site; other site 698936012964 Isochorismatase family; Region: Isochorismatase; pfam00857 698936012965 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 698936012966 catalytic triad [active] 698936012967 conserved cis-peptide bond; other site 698936012968 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 698936012969 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 698936012970 intersubunit interface [polypeptide binding]; other site 698936012971 active site 698936012972 Zn2+ binding site [ion binding]; other site 698936012973 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698936012974 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 698936012975 N- and C-terminal domain interface [polypeptide binding]; other site 698936012976 putative active site [active] 698936012977 putative MgATP binding site [chemical binding]; other site 698936012978 putative catalytic site [active] 698936012979 metal binding site [ion binding]; metal-binding site 698936012980 putative carbohydrate binding site [chemical binding]; other site 698936012981 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936012982 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 698936012983 DNA interaction; other site 698936012984 Metal-binding active site; metal-binding site 698936012985 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936012986 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936012987 TM-ABC transporter signature motif; other site 698936012988 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936012989 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936012990 TM-ABC transporter signature motif; other site 698936012991 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936012992 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936012993 Walker A/P-loop; other site 698936012994 ATP binding site [chemical binding]; other site 698936012995 Q-loop/lid; other site 698936012996 ABC transporter signature motif; other site 698936012997 Walker B; other site 698936012998 D-loop; other site 698936012999 H-loop/switch region; other site 698936013000 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936013001 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 698936013002 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698936013003 ligand binding site [chemical binding]; other site 698936013004 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936013005 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 698936013006 dimerization interface [polypeptide binding]; other site 698936013007 ligand binding site [chemical binding]; other site 698936013008 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 698936013009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936013010 Coenzyme A binding pocket [chemical binding]; other site 698936013011 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 698936013012 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 698936013013 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698936013014 active site 698936013015 dimer interface [polypeptide binding]; other site 698936013016 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698936013017 Ligand Binding Site [chemical binding]; other site 698936013018 Molecular Tunnel; other site 698936013019 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936013020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936013021 DNA-binding site [nucleotide binding]; DNA binding site 698936013022 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698936013023 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698936013024 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936013025 Walker A/P-loop; other site 698936013026 ATP binding site [chemical binding]; other site 698936013027 Q-loop/lid; other site 698936013028 ABC transporter signature motif; other site 698936013029 Walker B; other site 698936013030 D-loop; other site 698936013031 H-loop/switch region; other site 698936013032 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936013033 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698936013034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013035 dimer interface [polypeptide binding]; other site 698936013036 conserved gate region; other site 698936013037 putative PBP binding loops; other site 698936013038 ABC-ATPase subunit interface; other site 698936013039 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698936013040 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936013041 Walker A/P-loop; other site 698936013042 ATP binding site [chemical binding]; other site 698936013043 Q-loop/lid; other site 698936013044 ABC transporter signature motif; other site 698936013045 Walker B; other site 698936013046 D-loop; other site 698936013047 H-loop/switch region; other site 698936013048 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698936013049 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936013050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013051 dimer interface [polypeptide binding]; other site 698936013052 conserved gate region; other site 698936013053 putative PBP binding loops; other site 698936013054 ABC-ATPase subunit interface; other site 698936013055 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936013056 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 698936013057 peptide binding site [polypeptide binding]; other site 698936013058 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 698936013059 dimer interface [polypeptide binding]; other site 698936013060 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 698936013061 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 698936013062 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 698936013063 putative oligomer interface [polypeptide binding]; other site 698936013064 putative active site [active] 698936013065 metal binding site [ion binding]; metal-binding site 698936013066 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698936013067 nucleotide binding site [chemical binding]; other site 698936013068 Protein of unknown function (DUF995); Region: DUF995; pfam06191 698936013069 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 698936013070 Protein of unknown function (DUF995); Region: DUF995; pfam06191 698936013071 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 698936013072 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698936013073 active site 698936013074 Cellulose synthase-like protein; Region: PLN02893 698936013075 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698936013076 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698936013077 NAD binding site [chemical binding]; other site 698936013078 homodimer interface [polypeptide binding]; other site 698936013079 active site 698936013080 substrate binding site [chemical binding]; other site 698936013081 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936013082 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 698936013083 NAD binding site [chemical binding]; other site 698936013084 putative substrate binding site 2 [chemical binding]; other site 698936013085 putative substrate binding site 1 [chemical binding]; other site 698936013086 active site 698936013087 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936013088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936013089 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 698936013090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936013091 NAD(P) binding site [chemical binding]; other site 698936013092 active site 698936013093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936013094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936013095 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 698936013096 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 698936013097 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 698936013098 anti sigma factor interaction site; other site 698936013099 regulatory phosphorylation site [posttranslational modification]; other site 698936013100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 698936013101 Cache domain; Region: Cache_1; pfam02743 698936013102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698936013103 dimerization interface [polypeptide binding]; other site 698936013104 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 698936013105 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 698936013106 Uncharacterized conserved protein [Function unknown]; Region: COG5439 698936013107 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698936013108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936013109 S-adenosylmethionine binding site [chemical binding]; other site 698936013110 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936013111 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936013112 metal binding site [ion binding]; metal-binding site 698936013113 active site 698936013114 I-site; other site 698936013115 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698936013116 mannonate dehydratase; Provisional; Region: PRK03906 698936013117 mannonate dehydratase; Region: uxuA; TIGR00695 698936013118 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 698936013119 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 698936013120 putative NAD(P) binding site [chemical binding]; other site 698936013121 catalytic Zn binding site [ion binding]; other site 698936013122 DctM-like transporters; Region: DctM; pfam06808 698936013123 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 698936013124 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 698936013125 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 698936013126 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 698936013127 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936013128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936013129 DNA-binding site [nucleotide binding]; DNA binding site 698936013130 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698936013131 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 698936013132 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 698936013133 putative active site [active] 698936013134 Zn binding site [ion binding]; other site 698936013135 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 698936013136 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698936013137 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 698936013138 active site 698936013139 ectoine utilization protein EutC; Validated; Region: PRK08291 698936013140 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 698936013141 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 698936013142 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698936013143 tetramer interface [polypeptide binding]; other site 698936013144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936013145 catalytic residue [active] 698936013146 ectoine utilization protein EutA; Region: ectoine_eutA; TIGR02990 698936013147 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936013148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013149 dimer interface [polypeptide binding]; other site 698936013150 conserved gate region; other site 698936013151 putative PBP binding loops; other site 698936013152 ABC-ATPase subunit interface; other site 698936013153 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936013154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013155 dimer interface [polypeptide binding]; other site 698936013156 conserved gate region; other site 698936013157 putative PBP binding loops; other site 698936013158 ABC-ATPase subunit interface; other site 698936013159 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 698936013160 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936013161 substrate binding pocket [chemical binding]; other site 698936013162 membrane-bound complex binding site; other site 698936013163 hinge residues; other site 698936013164 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 698936013165 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698936013166 Walker A/P-loop; other site 698936013167 ATP binding site [chemical binding]; other site 698936013168 Q-loop/lid; other site 698936013169 ABC transporter signature motif; other site 698936013170 Walker B; other site 698936013171 D-loop; other site 698936013172 H-loop/switch region; other site 698936013173 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698936013174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936013175 DNA-binding site [nucleotide binding]; DNA binding site 698936013176 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936013177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936013178 homodimer interface [polypeptide binding]; other site 698936013179 catalytic residue [active] 698936013180 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936013181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936013182 putative DNA binding site [nucleotide binding]; other site 698936013183 putative Zn2+ binding site [ion binding]; other site 698936013184 AsnC family; Region: AsnC_trans_reg; pfam01037 698936013185 succinic semialdehyde dehydrogenase; Region: PLN02278 698936013186 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698936013187 tetramerization interface [polypeptide binding]; other site 698936013188 NAD(P) binding site [chemical binding]; other site 698936013189 catalytic residues [active] 698936013190 hypothetical protein; Provisional; Region: PRK07482 698936013191 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698936013192 inhibitor-cofactor binding pocket; inhibition site 698936013193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936013194 catalytic residue [active] 698936013195 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 698936013196 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698936013197 putative NAD(P) binding site [chemical binding]; other site 698936013198 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936013199 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 698936013200 putative C-terminal domain interface [polypeptide binding]; other site 698936013201 putative GSH binding site (G-site) [chemical binding]; other site 698936013202 putative dimer interface [polypeptide binding]; other site 698936013203 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 698936013204 dimer interface [polypeptide binding]; other site 698936013205 N-terminal domain interface [polypeptide binding]; other site 698936013206 putative substrate binding pocket (H-site) [chemical binding]; other site 698936013207 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936013208 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936013209 Walker A/P-loop; other site 698936013210 ATP binding site [chemical binding]; other site 698936013211 Q-loop/lid; other site 698936013212 ABC transporter signature motif; other site 698936013213 Walker B; other site 698936013214 D-loop; other site 698936013215 H-loop/switch region; other site 698936013216 TOBE domain; Region: TOBE_2; pfam08402 698936013217 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936013218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013219 dimer interface [polypeptide binding]; other site 698936013220 conserved gate region; other site 698936013221 ABC-ATPase subunit interface; other site 698936013222 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 698936013223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013224 dimer interface [polypeptide binding]; other site 698936013225 conserved gate region; other site 698936013226 putative PBP binding loops; other site 698936013227 ABC-ATPase subunit interface; other site 698936013228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698936013229 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936013230 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 698936013231 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936013232 putative NAD(P) binding site [chemical binding]; other site 698936013233 active site 698936013234 DoxX-like family; Region: DoxX_3; pfam13781 698936013235 Predicted integral membrane protein [Function unknown]; Region: COG5528 698936013236 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 698936013237 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 698936013238 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 698936013239 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 698936013240 classical (c) SDRs; Region: SDR_c; cd05233 698936013241 NAD(P) binding site [chemical binding]; other site 698936013242 active site 698936013243 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 698936013244 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 698936013245 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 698936013246 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 698936013247 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 698936013248 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 698936013249 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 698936013250 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936013251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936013252 DNA binding residues [nucleotide binding] 698936013253 dimerization interface [polypeptide binding]; other site 698936013254 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698936013255 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936013256 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698936013257 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936013258 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936013259 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 698936013260 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936013261 catalytic loop [active] 698936013262 iron binding site [ion binding]; other site 698936013263 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698936013264 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698936013265 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698936013266 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698936013267 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 698936013268 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 698936013269 putative active site [active] 698936013270 putative metal binding site [ion binding]; other site 698936013271 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 698936013272 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936013273 catalytic loop [active] 698936013274 iron binding site [ion binding]; other site 698936013275 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698936013276 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 698936013277 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 698936013278 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698936013279 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698936013280 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936013281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 698936013282 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 698936013283 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 698936013284 dimer interface [polypeptide binding]; other site 698936013285 active site 698936013286 catalytic residue [active] 698936013287 metal binding site [ion binding]; metal-binding site 698936013288 transcriptional regulator NanR; Provisional; Region: PRK03837 698936013289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936013290 DNA-binding site [nucleotide binding]; DNA binding site 698936013291 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 698936013292 FCD domain; Region: FCD; pfam07729 698936013293 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 698936013294 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698936013295 DXD motif; other site 698936013296 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 698936013297 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936013298 GAF domain; Region: GAF; pfam01590 698936013299 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 698936013300 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936013301 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936013302 metal binding site [ion binding]; metal-binding site 698936013303 active site 698936013304 I-site; other site 698936013305 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 698936013306 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698936013307 NAD(P) binding site [chemical binding]; other site 698936013308 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698936013309 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 698936013310 Bacterial transcriptional regulator; Region: IclR; pfam01614 698936013311 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 698936013312 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 698936013313 active site 698936013314 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698936013315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698936013316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013317 dimer interface [polypeptide binding]; other site 698936013318 putative PBP binding loops; other site 698936013319 ABC-ATPase subunit interface; other site 698936013320 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936013321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013322 dimer interface [polypeptide binding]; other site 698936013323 conserved gate region; other site 698936013324 putative PBP binding loops; other site 698936013325 ABC-ATPase subunit interface; other site 698936013326 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698936013327 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 698936013328 Walker A/P-loop; other site 698936013329 ATP binding site [chemical binding]; other site 698936013330 Q-loop/lid; other site 698936013331 ABC transporter signature motif; other site 698936013332 Walker B; other site 698936013333 D-loop; other site 698936013334 H-loop/switch region; other site 698936013335 aminotransferase; Provisional; Region: PRK06105 698936013336 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698936013337 inhibitor-cofactor binding pocket; inhibition site 698936013338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936013339 catalytic residue [active] 698936013340 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698936013341 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698936013342 tetramerization interface [polypeptide binding]; other site 698936013343 NAD(P) binding site [chemical binding]; other site 698936013344 catalytic residues [active] 698936013345 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698936013346 homotrimer interaction site [polypeptide binding]; other site 698936013347 putative active site [active] 698936013348 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698936013349 homotrimer interaction site [polypeptide binding]; other site 698936013350 putative active site [active] 698936013351 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936013352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936013353 DNA-binding site [nucleotide binding]; DNA binding site 698936013354 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698936013355 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 698936013356 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 698936013357 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 698936013358 DctM-like transporters; Region: DctM; pfam06808 698936013359 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 698936013360 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698936013361 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698936013362 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698936013363 Walker A/P-loop; other site 698936013364 ATP binding site [chemical binding]; other site 698936013365 Q-loop/lid; other site 698936013366 ABC transporter signature motif; other site 698936013367 Walker B; other site 698936013368 D-loop; other site 698936013369 H-loop/switch region; other site 698936013370 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 698936013371 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698936013372 FtsX-like permease family; Region: FtsX; pfam02687 698936013373 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698936013374 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936013375 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936013376 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936013377 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936013378 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936013379 DNA binding site [nucleotide binding] 698936013380 domain linker motif; other site 698936013381 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 698936013382 putative dimerization interface [polypeptide binding]; other site 698936013383 putative ligand binding site [chemical binding]; other site 698936013384 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698936013385 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698936013386 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 698936013387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013388 dimer interface [polypeptide binding]; other site 698936013389 conserved gate region; other site 698936013390 putative PBP binding loops; other site 698936013391 ABC-ATPase subunit interface; other site 698936013392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013393 dimer interface [polypeptide binding]; other site 698936013394 conserved gate region; other site 698936013395 putative PBP binding loops; other site 698936013396 ABC-ATPase subunit interface; other site 698936013397 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698936013398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936013399 Walker A/P-loop; other site 698936013400 ATP binding site [chemical binding]; other site 698936013401 Q-loop/lid; other site 698936013402 ABC transporter signature motif; other site 698936013403 Walker B; other site 698936013404 D-loop; other site 698936013405 H-loop/switch region; other site 698936013406 TOBE domain; Region: TOBE_2; pfam08402 698936013407 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698936013408 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 698936013409 active site 698936013410 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698936013411 Ion channel; Region: Ion_trans_2; pfam07885 698936013412 Predicted periplasmic protein [Function unknown]; Region: COG3904 698936013413 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936013414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936013415 phosphorylation site [posttranslational modification] 698936013416 dimer interface [polypeptide binding]; other site 698936013417 Response regulator receiver domain; Region: Response_reg; pfam00072 698936013418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936013419 active site 698936013420 phosphorylation site [posttranslational modification] 698936013421 intermolecular recognition site; other site 698936013422 dimerization interface [polypeptide binding]; other site 698936013423 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 698936013424 cyclase homology domain; Region: CHD; cd07302 698936013425 nucleotidyl binding site; other site 698936013426 metal binding site [ion binding]; metal-binding site 698936013427 dimer interface [polypeptide binding]; other site 698936013428 Response regulator receiver domain; Region: Response_reg; pfam00072 698936013429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936013430 active site 698936013431 phosphorylation site [posttranslational modification] 698936013432 intermolecular recognition site; other site 698936013433 dimerization interface [polypeptide binding]; other site 698936013434 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698936013435 dimerization interface [polypeptide binding]; other site 698936013436 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698936013437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936013438 dimer interface [polypeptide binding]; other site 698936013439 phosphorylation site [posttranslational modification] 698936013440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936013441 ATP binding site [chemical binding]; other site 698936013442 Mg2+ binding site [ion binding]; other site 698936013443 G-X-G motif; other site 698936013444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936013445 Response regulator receiver domain; Region: Response_reg; pfam00072 698936013446 active site 698936013447 phosphorylation site [posttranslational modification] 698936013448 intermolecular recognition site; other site 698936013449 dimerization interface [polypeptide binding]; other site 698936013450 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698936013451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936013452 active site 698936013453 phosphorylation site [posttranslational modification] 698936013454 intermolecular recognition site; other site 698936013455 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 698936013456 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936013457 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936013458 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936013459 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936013460 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936013461 TM-ABC transporter signature motif; other site 698936013462 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936013463 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936013464 Walker A/P-loop; other site 698936013465 ATP binding site [chemical binding]; other site 698936013466 Q-loop/lid; other site 698936013467 ABC transporter signature motif; other site 698936013468 Walker B; other site 698936013469 D-loop; other site 698936013470 H-loop/switch region; other site 698936013471 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936013472 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5618 698936013473 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 698936013474 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698936013475 ligand binding site [chemical binding]; other site 698936013476 dimerization interface [polypeptide binding]; other site 698936013477 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 698936013478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936013479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936013480 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698936013481 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936013482 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936013483 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698936013484 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 698936013485 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698936013486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936013487 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 698936013488 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936013489 catalytic loop [active] 698936013490 iron binding site [ion binding]; other site 698936013491 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698936013492 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698936013493 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698936013494 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936013495 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936013496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936013497 putative substrate translocation pore; other site 698936013498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936013499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936013500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 698936013501 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 698936013502 Uncharacterized conserved protein [Function unknown]; Region: COG1262 698936013503 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 698936013504 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 698936013505 Sulfatase; Region: Sulfatase; cl17466 698936013506 SPW repeat; Region: SPW; pfam03779 698936013507 SPW repeat; Region: SPW; pfam03779 698936013508 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936013509 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936013510 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936013511 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 698936013512 conserved cys residue [active] 698936013513 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936013514 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936013515 Walker A/P-loop; other site 698936013516 ATP binding site [chemical binding]; other site 698936013517 Q-loop/lid; other site 698936013518 ABC transporter signature motif; other site 698936013519 Walker B; other site 698936013520 D-loop; other site 698936013521 H-loop/switch region; other site 698936013522 TOBE domain; Region: TOBE_2; pfam08402 698936013523 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936013524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013525 dimer interface [polypeptide binding]; other site 698936013526 conserved gate region; other site 698936013527 putative PBP binding loops; other site 698936013528 ABC-ATPase subunit interface; other site 698936013529 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936013530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013531 dimer interface [polypeptide binding]; other site 698936013532 conserved gate region; other site 698936013533 putative PBP binding loops; other site 698936013534 ABC-ATPase subunit interface; other site 698936013535 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936013536 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698936013537 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936013538 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936013539 DNA binding site [nucleotide binding] 698936013540 domain linker motif; other site 698936013541 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 698936013542 ligand binding site [chemical binding]; other site 698936013543 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936013544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936013545 DNA-binding site [nucleotide binding]; DNA binding site 698936013546 FCD domain; Region: FCD; pfam07729 698936013547 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 698936013548 DctM-like transporters; Region: DctM; pfam06808 698936013549 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 698936013550 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 698936013551 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 698936013552 Predicted flavoproteins [General function prediction only]; Region: COG2081 698936013553 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936013554 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936013555 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936013556 TM-ABC transporter signature motif; other site 698936013557 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936013558 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936013559 Walker A/P-loop; other site 698936013560 ATP binding site [chemical binding]; other site 698936013561 Q-loop/lid; other site 698936013562 ABC transporter signature motif; other site 698936013563 Walker B; other site 698936013564 D-loop; other site 698936013565 H-loop/switch region; other site 698936013566 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936013567 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 698936013568 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698936013569 ligand binding site [chemical binding]; other site 698936013570 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936013571 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936013572 TM-ABC transporter signature motif; other site 698936013573 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 698936013574 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 698936013575 DAK2 domain; Region: Dak2; pfam02734 698936013576 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698936013577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936013578 DNA binding residues [nucleotide binding] 698936013579 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698936013580 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 698936013581 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 698936013582 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 698936013583 DAK2 domain; Region: Dak2; cl03685 698936013584 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 698936013585 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 698936013586 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936013587 cyclase homology domain; Region: CHD; cd07302 698936013588 nucleotidyl binding site; other site 698936013589 metal binding site [ion binding]; metal-binding site 698936013590 dimer interface [polypeptide binding]; other site 698936013591 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936013592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936013593 binding surface 698936013594 TPR motif; other site 698936013595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936013596 TPR motif; other site 698936013597 Tetratricopeptide repeat; Region: TPR_16; pfam13432 698936013598 binding surface 698936013599 N-acetylneuraminate lyase; Provisional; Region: PRK04147 698936013600 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 698936013601 inhibitor site; inhibition site 698936013602 active site 698936013603 dimer interface [polypeptide binding]; other site 698936013604 catalytic residue [active] 698936013605 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698936013606 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698936013607 inhibitor site; inhibition site 698936013608 active site 698936013609 dimer interface [polypeptide binding]; other site 698936013610 catalytic residue [active] 698936013611 DctM-like transporters; Region: DctM; pfam06808 698936013612 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 698936013613 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 698936013614 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 698936013615 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 698936013616 transcriptional regulator NanR; Provisional; Region: PRK03837 698936013617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936013618 DNA-binding site [nucleotide binding]; DNA binding site 698936013619 FCD domain; Region: FCD; pfam07729 698936013620 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 698936013621 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 698936013622 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 698936013623 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 698936013624 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 698936013625 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936013626 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936013627 DNA binding site [nucleotide binding] 698936013628 domain linker motif; other site 698936013629 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 698936013630 putative dimerization interface [polypeptide binding]; other site 698936013631 putative ligand binding site [chemical binding]; other site 698936013632 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 698936013633 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 698936013634 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 698936013635 active site 698936013636 putative substrate binding pocket [chemical binding]; other site 698936013637 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698936013638 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 698936013639 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936013640 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936013641 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936013642 dimerization interface [polypeptide binding]; other site 698936013643 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698936013644 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698936013645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698936013646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013647 ABC-ATPase subunit interface; other site 698936013648 putative PBP binding loops; other site 698936013649 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936013650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013651 dimer interface [polypeptide binding]; other site 698936013652 conserved gate region; other site 698936013653 putative PBP binding loops; other site 698936013654 ABC-ATPase subunit interface; other site 698936013655 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698936013656 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 698936013657 Walker A/P-loop; other site 698936013658 ATP binding site [chemical binding]; other site 698936013659 Q-loop/lid; other site 698936013660 ABC transporter signature motif; other site 698936013661 Walker B; other site 698936013662 D-loop; other site 698936013663 H-loop/switch region; other site 698936013664 TOBE domain; Region: TOBE_2; pfam08402 698936013665 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 698936013666 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698936013667 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698936013668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 698936013669 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 698936013670 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 698936013671 hypothetical protein; Provisional; Region: PRK07483 698936013672 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698936013673 inhibitor-cofactor binding pocket; inhibition site 698936013674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936013675 catalytic residue [active] 698936013676 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698936013677 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698936013678 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698936013679 putative active site [active] 698936013680 Uncharacterized conserved protein [Function unknown]; Region: COG3246 698936013681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936013682 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936013683 putative substrate translocation pore; other site 698936013684 OsmC-like protein; Region: OsmC; cl00767 698936013685 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 698936013686 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 698936013687 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 698936013688 substrate binding site [chemical binding]; other site 698936013689 Protein of unknown function (DUF521); Region: DUF521; pfam04412 698936013690 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 698936013691 substrate binding site [chemical binding]; other site 698936013692 ligand binding site [chemical binding]; other site 698936013693 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 698936013694 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 698936013695 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698936013696 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 698936013697 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936013698 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698936013699 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698936013700 Walker A/P-loop; other site 698936013701 ATP binding site [chemical binding]; other site 698936013702 Q-loop/lid; other site 698936013703 ABC transporter signature motif; other site 698936013704 Walker B; other site 698936013705 D-loop; other site 698936013706 H-loop/switch region; other site 698936013707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013708 dimer interface [polypeptide binding]; other site 698936013709 conserved gate region; other site 698936013710 putative PBP binding loops; other site 698936013711 ABC-ATPase subunit interface; other site 698936013712 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936013713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013714 dimer interface [polypeptide binding]; other site 698936013715 conserved gate region; other site 698936013716 putative PBP binding loops; other site 698936013717 ABC-ATPase subunit interface; other site 698936013718 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698936013719 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936013720 substrate binding pocket [chemical binding]; other site 698936013721 membrane-bound complex binding site; other site 698936013722 hinge residues; other site 698936013723 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 698936013724 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 698936013725 dimer interface [polypeptide binding]; other site 698936013726 NADP binding site [chemical binding]; other site 698936013727 catalytic residues [active] 698936013728 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 698936013729 Uncharacterized conserved protein [Function unknown]; Region: COG3339 698936013730 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698936013731 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698936013732 inhibitor site; inhibition site 698936013733 active site 698936013734 dimer interface [polypeptide binding]; other site 698936013735 catalytic residue [active] 698936013736 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936013737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936013738 DNA-binding site [nucleotide binding]; DNA binding site 698936013739 FCD domain; Region: FCD; pfam07729 698936013740 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936013741 cyclase homology domain; Region: CHD; cd07302 698936013742 nucleotidyl binding site; other site 698936013743 metal binding site [ion binding]; metal-binding site 698936013744 dimer interface [polypeptide binding]; other site 698936013745 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 698936013746 putative hydrophobic ligand binding site [chemical binding]; other site 698936013747 Predicted membrane protein [Function unknown]; Region: COG4420 698936013748 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 698936013749 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 698936013750 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 698936013751 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 698936013752 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 698936013753 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698936013754 catalytic core [active] 698936013755 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 698936013756 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 698936013757 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936013758 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936013759 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936013760 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698936013761 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 698936013762 putative NAD(P) binding site [chemical binding]; other site 698936013763 catalytic Zn binding site [ion binding]; other site 698936013764 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936013765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936013766 NAD(P) binding site [chemical binding]; other site 698936013767 active site 698936013768 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 698936013769 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936013770 NAD binding site [chemical binding]; other site 698936013771 homotetramer interface [polypeptide binding]; other site 698936013772 homodimer interface [polypeptide binding]; other site 698936013773 active site 698936013774 substrate binding site [chemical binding]; other site 698936013775 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698936013776 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936013777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 698936013778 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 698936013779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 698936013780 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 698936013781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 698936013782 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 698936013783 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 698936013784 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936013785 NAD binding site [chemical binding]; other site 698936013786 putative substrate binding site 2 [chemical binding]; other site 698936013787 putative substrate binding site 1 [chemical binding]; other site 698936013788 active site 698936013789 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698936013790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936013791 S-adenosylmethionine binding site [chemical binding]; other site 698936013792 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936013793 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936013794 Walker A/P-loop; other site 698936013795 ATP binding site [chemical binding]; other site 698936013796 Q-loop/lid; other site 698936013797 ABC transporter signature motif; other site 698936013798 Walker B; other site 698936013799 D-loop; other site 698936013800 H-loop/switch region; other site 698936013801 TOBE domain; Region: TOBE_2; pfam08402 698936013802 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 698936013803 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936013804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013805 dimer interface [polypeptide binding]; other site 698936013806 conserved gate region; other site 698936013807 putative PBP binding loops; other site 698936013808 ABC-ATPase subunit interface; other site 698936013809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698936013810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013811 ABC-ATPase subunit interface; other site 698936013812 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936013813 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936013814 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936013815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936013816 DNA binding site [nucleotide binding] 698936013817 domain linker motif; other site 698936013818 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698936013819 dimerization interface [polypeptide binding]; other site 698936013820 ligand binding site [chemical binding]; other site 698936013821 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 698936013822 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 698936013823 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 698936013824 BON domain; Region: BON; pfam04972 698936013825 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 698936013826 Cupin domain; Region: Cupin_2; pfam07883 698936013827 Epoxide hydrolase N terminus; Region: EHN; pfam06441 698936013828 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698936013829 osmolarity response regulator; Provisional; Region: ompR; PRK09468 698936013830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936013831 active site 698936013832 phosphorylation site [posttranslational modification] 698936013833 intermolecular recognition site; other site 698936013834 dimerization interface [polypeptide binding]; other site 698936013835 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936013836 DNA binding site [nucleotide binding] 698936013837 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 698936013838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 698936013839 dimer interface [polypeptide binding]; other site 698936013840 phosphorylation site [posttranslational modification] 698936013841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936013842 ATP binding site [chemical binding]; other site 698936013843 Mg2+ binding site [ion binding]; other site 698936013844 G-X-G motif; other site 698936013845 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 698936013846 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936013847 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698936013848 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 698936013849 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 698936013850 conserved cys residue [active] 698936013851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936013852 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698936013853 classical (c) SDRs; Region: SDR_c; cd05233 698936013854 NAD(P) binding site [chemical binding]; other site 698936013855 active site 698936013856 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698936013857 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698936013858 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 698936013859 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698936013860 catalytic residues [active] 698936013861 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 698936013862 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 698936013863 potential catalytic triad [active] 698936013864 conserved cys residue [active] 698936013865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936013866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936013867 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 698936013868 putative effector binding pocket; other site 698936013869 putative dimerization interface [polypeptide binding]; other site 698936013870 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 698936013871 classical (c) SDRs; Region: SDR_c; cd05233 698936013872 NAD(P) binding site [chemical binding]; other site 698936013873 active site 698936013874 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 698936013875 active site 1 [active] 698936013876 dimer interface [polypeptide binding]; other site 698936013877 hexamer interface [polypeptide binding]; other site 698936013878 active site 2 [active] 698936013879 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 698936013880 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698936013881 FeS/SAM binding site; other site 698936013882 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 698936013883 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 698936013884 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 698936013885 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 698936013886 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 698936013887 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 698936013888 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936013889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936013890 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 698936013891 putative dimerization interface [polypeptide binding]; other site 698936013892 fructose-1,6-bisphosphatase family protein; Region: PLN02628 698936013893 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 698936013894 AMP binding site [chemical binding]; other site 698936013895 metal binding site [ion binding]; metal-binding site 698936013896 active site 698936013897 phosphoribulokinase; Provisional; Region: PRK15453 698936013898 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698936013899 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698936013900 TPP-binding site [chemical binding]; other site 698936013901 dimer interface [polypeptide binding]; other site 698936013902 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698936013903 PYR/PP interface [polypeptide binding]; other site 698936013904 dimer interface [polypeptide binding]; other site 698936013905 TPP binding site [chemical binding]; other site 698936013906 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698936013907 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698936013908 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 698936013909 intersubunit interface [polypeptide binding]; other site 698936013910 active site 698936013911 zinc binding site [ion binding]; other site 698936013912 Na+ binding site [ion binding]; other site 698936013913 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 698936013914 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 698936013915 homodimer interface [polypeptide binding]; other site 698936013916 active site 698936013917 heterodimer interface [polypeptide binding]; other site 698936013918 catalytic residue [active] 698936013919 metal binding site [ion binding]; metal-binding site 698936013920 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 698936013921 multimerization interface [polypeptide binding]; other site 698936013922 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 698936013923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936013924 Walker A motif; other site 698936013925 ATP binding site [chemical binding]; other site 698936013926 Walker B motif; other site 698936013927 arginine finger; other site 698936013928 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698936013929 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698936013930 substrate binding site [chemical binding]; other site 698936013931 hexamer interface [polypeptide binding]; other site 698936013932 metal binding site [ion binding]; metal-binding site 698936013933 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 698936013934 putative catalytic residue [active] 698936013935 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 698936013936 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 698936013937 alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861 698936013938 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 698936013939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936013940 Walker A/P-loop; other site 698936013941 ATP binding site [chemical binding]; other site 698936013942 Q-loop/lid; other site 698936013943 ABC transporter signature motif; other site 698936013944 Walker B; other site 698936013945 D-loop; other site 698936013946 H-loop/switch region; other site 698936013947 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698936013948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936013949 Walker A/P-loop; other site 698936013950 ATP binding site [chemical binding]; other site 698936013951 Q-loop/lid; other site 698936013952 ABC transporter signature motif; other site 698936013953 Walker B; other site 698936013954 D-loop; other site 698936013955 H-loop/switch region; other site 698936013956 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698936013957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936013958 dimer interface [polypeptide binding]; other site 698936013959 conserved gate region; other site 698936013960 putative PBP binding loops; other site 698936013961 ABC-ATPase subunit interface; other site 698936013962 NMT1/THI5 like; Region: NMT1; pfam09084 698936013963 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 698936013964 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 698936013965 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 698936013966 structural tetrad; other site 698936013967 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 698936013968 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 698936013969 ligand binding site [chemical binding]; other site 698936013970 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 698936013971 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698936013972 active site residue [active] 698936013973 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 698936013974 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936013975 substrate binding pocket [chemical binding]; other site 698936013976 membrane-bound complex binding site; other site 698936013977 hinge residues; other site 698936013978 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698936013979 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 698936013980 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 698936013981 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 698936013982 Trp docking motif [polypeptide binding]; other site 698936013983 dimer interface [polypeptide binding]; other site 698936013984 active site 698936013985 small subunit binding site [polypeptide binding]; other site 698936013986 Cytochrome c2 [Energy production and conversion]; Region: COG3474 698936013987 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 698936013988 S-formylglutathione hydrolase; Region: PLN02442 698936013989 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 698936013990 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 698936013991 substrate binding site [chemical binding]; other site 698936013992 catalytic Zn binding site [ion binding]; other site 698936013993 NAD binding site [chemical binding]; other site 698936013994 structural Zn binding site [ion binding]; other site 698936013995 dimer interface [polypeptide binding]; other site 698936013996 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698936013997 Predicted secreted protein [Function unknown]; Region: COG5501 698936013998 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 698936013999 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 698936014000 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698936014001 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936014002 dimer interface [polypeptide binding]; other site 698936014003 phosphorylation site [posttranslational modification] 698936014004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936014005 ATP binding site [chemical binding]; other site 698936014006 Mg2+ binding site [ion binding]; other site 698936014007 G-X-G motif; other site 698936014008 Response regulator receiver domain; Region: Response_reg; pfam00072 698936014009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936014010 active site 698936014011 phosphorylation site [posttranslational modification] 698936014012 intermolecular recognition site; other site 698936014013 dimerization interface [polypeptide binding]; other site 698936014014 Uncharacterized conserved protein [Function unknown]; Region: COG3287 698936014015 FIST N domain; Region: FIST; pfam08495 698936014016 FIST C domain; Region: FIST_C; pfam10442 698936014017 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936014018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936014019 active site 698936014020 phosphorylation site [posttranslational modification] 698936014021 intermolecular recognition site; other site 698936014022 dimerization interface [polypeptide binding]; other site 698936014023 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936014024 DNA binding residues [nucleotide binding] 698936014025 dimerization interface [polypeptide binding]; other site 698936014026 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698936014027 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698936014028 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 698936014029 active site 698936014030 catalytic residues [active] 698936014031 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698936014032 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698936014033 active site 698936014034 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 698936014035 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698936014036 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698936014037 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698936014038 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698936014039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936014040 Walker A/P-loop; other site 698936014041 ATP binding site [chemical binding]; other site 698936014042 Q-loop/lid; other site 698936014043 ABC transporter signature motif; other site 698936014044 Walker B; other site 698936014045 D-loop; other site 698936014046 H-loop/switch region; other site 698936014047 TOBE domain; Region: TOBE_2; pfam08402 698936014048 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 698936014049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936014050 dimer interface [polypeptide binding]; other site 698936014051 conserved gate region; other site 698936014052 putative PBP binding loops; other site 698936014053 ABC-ATPase subunit interface; other site 698936014054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936014055 dimer interface [polypeptide binding]; other site 698936014056 conserved gate region; other site 698936014057 putative PBP binding loops; other site 698936014058 ABC-ATPase subunit interface; other site 698936014059 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936014060 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936014061 DNA binding site [nucleotide binding] 698936014062 domain linker motif; other site 698936014063 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 698936014064 putative dimerization interface [polypeptide binding]; other site 698936014065 putative ligand binding site [chemical binding]; other site 698936014066 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 698936014067 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 698936014068 PhoU domain; Region: PhoU; pfam01895 698936014069 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 698936014070 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 698936014071 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 698936014072 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 698936014073 active site 698936014074 catalytic residues [active] 698936014075 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698936014076 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698936014077 active site 698936014078 dimerization interface [polypeptide binding]; other site 698936014079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 698936014080 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936014081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936014082 DNA-binding site [nucleotide binding]; DNA binding site 698936014083 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698936014084 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 698936014085 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 698936014086 putative active site [active] 698936014087 metal binding site [ion binding]; metal-binding site 698936014088 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 698936014089 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 698936014090 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 698936014091 BNR repeat-like domain; Region: BNR_2; pfam13088 698936014092 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936014093 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 698936014094 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936014095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936014096 dimer interface [polypeptide binding]; other site 698936014097 conserved gate region; other site 698936014098 putative PBP binding loops; other site 698936014099 ABC-ATPase subunit interface; other site 698936014100 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698936014101 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 698936014102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936014103 dimer interface [polypeptide binding]; other site 698936014104 conserved gate region; other site 698936014105 putative PBP binding loops; other site 698936014106 ABC-ATPase subunit interface; other site 698936014107 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698936014108 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936014109 Walker A/P-loop; other site 698936014110 ATP binding site [chemical binding]; other site 698936014111 Q-loop/lid; other site 698936014112 ABC transporter signature motif; other site 698936014113 Walker B; other site 698936014114 D-loop; other site 698936014115 H-loop/switch region; other site 698936014116 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936014117 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936014118 Walker A/P-loop; other site 698936014119 ATP binding site [chemical binding]; other site 698936014120 Q-loop/lid; other site 698936014121 ABC transporter signature motif; other site 698936014122 Walker B; other site 698936014123 D-loop; other site 698936014124 H-loop/switch region; other site 698936014125 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936014126 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698936014127 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698936014128 inhibitor site; inhibition site 698936014129 active site 698936014130 dimer interface [polypeptide binding]; other site 698936014131 catalytic residue [active] 698936014132 Predicted membrane protein [Function unknown]; Region: COG4329 698936014133 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 698936014134 active site 698936014135 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 698936014136 active site 698936014137 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 698936014138 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 698936014139 Flavoprotein; Region: Flavoprotein; pfam02441 698936014140 xanthine permease; Region: pbuX; TIGR03173 698936014141 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698936014142 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 698936014143 P-loop, Walker A motif; other site 698936014144 Base recognition motif; other site 698936014145 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 698936014146 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698936014147 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698936014148 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936014149 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 698936014150 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936014151 catalytic loop [active] 698936014152 iron binding site [ion binding]; other site 698936014153 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698936014154 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 698936014155 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 698936014156 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936014157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 698936014158 DNA-binding site [nucleotide binding]; DNA binding site 698936014159 FCD domain; Region: FCD; pfam07729 698936014160 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 698936014161 cytosine deaminase; Provisional; Region: PRK05985 698936014162 active site 698936014163 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 698936014164 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 698936014165 putative ligand binding site [chemical binding]; other site 698936014166 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936014167 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698936014168 TM-ABC transporter signature motif; other site 698936014169 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936014170 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698936014171 TM-ABC transporter signature motif; other site 698936014172 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 698936014173 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936014174 Walker A/P-loop; other site 698936014175 ATP binding site [chemical binding]; other site 698936014176 Q-loop/lid; other site 698936014177 ABC transporter signature motif; other site 698936014178 Walker B; other site 698936014179 D-loop; other site 698936014180 H-loop/switch region; other site 698936014181 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936014182 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936014183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936014184 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 698936014185 putative dimerization interface [polypeptide binding]; other site 698936014186 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 698936014187 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 698936014188 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 698936014189 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936014190 putative ADP-binding pocket [chemical binding]; other site 698936014191 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 698936014192 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 698936014193 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 698936014194 hypothetical protein; Validated; Region: PRK08245 698936014195 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 698936014196 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 698936014197 putative ligand binding site [chemical binding]; other site 698936014198 NAD binding site [chemical binding]; other site 698936014199 catalytic site [active] 698936014200 EamA-like transporter family; Region: EamA; pfam00892 698936014201 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 698936014202 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698936014203 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936014204 Walker A/P-loop; other site 698936014205 ATP binding site [chemical binding]; other site 698936014206 Q-loop/lid; other site 698936014207 ABC transporter signature motif; other site 698936014208 Walker B; other site 698936014209 D-loop; other site 698936014210 H-loop/switch region; other site 698936014211 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936014212 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936014213 Walker A/P-loop; other site 698936014214 ATP binding site [chemical binding]; other site 698936014215 Q-loop/lid; other site 698936014216 ABC transporter signature motif; other site 698936014217 Walker B; other site 698936014218 D-loop; other site 698936014219 H-loop/switch region; other site 698936014220 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936014221 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698936014222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936014223 dimer interface [polypeptide binding]; other site 698936014224 conserved gate region; other site 698936014225 putative PBP binding loops; other site 698936014226 ABC-ATPase subunit interface; other site 698936014227 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936014228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936014229 dimer interface [polypeptide binding]; other site 698936014230 conserved gate region; other site 698936014231 putative PBP binding loops; other site 698936014232 ABC-ATPase subunit interface; other site 698936014233 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936014234 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 698936014235 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698936014236 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698936014237 inhibitor site; inhibition site 698936014238 active site 698936014239 dimer interface [polypeptide binding]; other site 698936014240 catalytic residue [active] 698936014241 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936014242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936014243 DNA-binding site [nucleotide binding]; DNA binding site 698936014244 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698936014245 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936014246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936014247 DNA-binding site [nucleotide binding]; DNA binding site 698936014248 FCD domain; Region: FCD; pfam07729 698936014249 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698936014250 SnoaL-like domain; Region: SnoaL_2; pfam12680 698936014251 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 698936014252 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 698936014253 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 698936014254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936014255 Walker A motif; other site 698936014256 ATP binding site [chemical binding]; other site 698936014257 Walker B motif; other site 698936014258 arginine finger; other site 698936014259 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 698936014260 Predicted dehydrogenase [General function prediction only]; Region: COG0579 698936014261 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936014262 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 698936014263 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 698936014264 trehalose synthase; Region: treS_nterm; TIGR02456 698936014265 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 698936014266 active site 698936014267 catalytic site [active] 698936014268 FAD binding domain; Region: FAD_binding_4; pfam01565 698936014269 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 698936014270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4288 698936014271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4288 698936014272 thiamine pyrophosphate protein; Provisional; Region: PRK08273 698936014273 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698936014274 PYR/PP interface [polypeptide binding]; other site 698936014275 dimer interface [polypeptide binding]; other site 698936014276 tetramer interface [polypeptide binding]; other site 698936014277 TPP binding site [chemical binding]; other site 698936014278 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698936014279 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698936014280 TPP-binding site [chemical binding]; other site 698936014281 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 698936014282 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 698936014283 putative active site [active] 698936014284 catalytic site [active] 698936014285 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 698936014286 putative active site [active] 698936014287 catalytic site [active] 698936014288 Predicted integral membrane protein [Function unknown]; Region: COG0392 698936014289 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 698936014290 putative catalytic site [active] 698936014291 putative metal binding site [ion binding]; other site 698936014292 putative phosphate binding site [ion binding]; other site 698936014293 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 698936014294 dinuclear metal binding motif [ion binding]; other site 698936014295 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 698936014296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936014297 S-adenosylmethionine binding site [chemical binding]; other site 698936014298 Erythromycin esterase; Region: Erythro_esteras; pfam05139 698936014299 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 698936014300 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 698936014301 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698936014302 active site 698936014303 metal binding site [ion binding]; metal-binding site 698936014304 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 698936014305 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698936014306 NAD binding site [chemical binding]; other site 698936014307 catalytic Zn binding site [ion binding]; other site 698936014308 structural Zn binding site [ion binding]; other site 698936014309 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 698936014310 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 698936014311 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 698936014312 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 698936014313 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936014314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936014315 active site 698936014316 phosphorylation site [posttranslational modification] 698936014317 intermolecular recognition site; other site 698936014318 dimerization interface [polypeptide binding]; other site 698936014319 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936014320 DNA binding residues [nucleotide binding] 698936014321 dimerization interface [polypeptide binding]; other site 698936014322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698936014323 Histidine kinase; Region: HisKA_3; pfam07730 698936014324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936014325 ATP binding site [chemical binding]; other site 698936014326 Mg2+ binding site [ion binding]; other site 698936014327 G-X-G motif; other site 698936014328 short chain dehydrogenase; Provisional; Region: PRK06139 698936014329 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 698936014330 putative NAD(P) binding site [chemical binding]; other site 698936014331 active site 698936014332 short chain dehydrogenase; Provisional; Region: PRK06701 698936014333 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 698936014334 NAD binding site [chemical binding]; other site 698936014335 metal binding site [ion binding]; metal-binding site 698936014336 active site 698936014337 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936014338 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 698936014339 putative ligand binding site [chemical binding]; other site 698936014340 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 698936014341 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 698936014342 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698936014343 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698936014344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936014345 putative substrate translocation pore; other site 698936014346 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 698936014347 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 698936014348 Sulfate transporter family; Region: Sulfate_transp; pfam00916 698936014349 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 698936014350 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698936014351 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 698936014352 Uncharacterized conserved protein [Function unknown]; Region: COG3360 698936014353 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 698936014354 trimer interface [polypeptide binding]; other site 698936014355 putative Zn binding site [ion binding]; other site 698936014356 Helix-turn-helix domain; Region: HTH_28; pfam13518 698936014357 Winged helix-turn helix; Region: HTH_29; pfam13551 698936014358 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 698936014359 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698936014360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936014361 S-adenosylmethionine binding site [chemical binding]; other site 698936014362 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698936014363 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698936014364 Walker A/P-loop; other site 698936014365 ATP binding site [chemical binding]; other site 698936014366 Q-loop/lid; other site 698936014367 ABC transporter signature motif; other site 698936014368 Walker B; other site 698936014369 D-loop; other site 698936014370 H-loop/switch region; other site 698936014371 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698936014372 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698936014373 ABC-ATPase subunit interface; other site 698936014374 dimer interface [polypeptide binding]; other site 698936014375 putative PBP binding regions; other site 698936014376 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698936014377 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698936014378 putative ligand binding residues [chemical binding]; other site 698936014379 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 698936014380 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 698936014381 DctM-like transporters; Region: DctM; pfam06808 698936014382 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 698936014383 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 698936014384 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 698936014385 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 698936014386 conserved cys residue [active] 698936014387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936014388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936014389 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698936014390 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936014391 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698936014392 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698936014393 elongation factor G; Reviewed; Region: PRK12740 698936014394 G1 box; other site 698936014395 GTP/Mg2+ binding site [chemical binding]; other site 698936014396 G2 box; other site 698936014397 G3 box; other site 698936014398 Switch II region; other site 698936014399 G4 box; other site 698936014400 G5 box; other site 698936014401 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698936014402 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698936014403 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 698936014404 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936014405 DNA-binding site [nucleotide binding]; DNA binding site 698936014406 UTRA domain; Region: UTRA; pfam07702 698936014407 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 698936014408 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698936014409 P-loop; other site 698936014410 Magnesium ion binding site [ion binding]; other site 698936014411 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698936014412 Magnesium ion binding site [ion binding]; other site 698936014413 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 698936014414 ParB-like nuclease domain; Region: ParB; smart00470 698936014415 replication initiation protein RepC; Provisional; Region: PRK13824 698936014416 Replication protein C N-terminal domain; Region: RP-C; pfam03428 698936014417 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 698936014418 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 698936014419 HTH DNA binding domain; Region: HTH_13; pfam11972 698936014420 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698936014421 EamA-like transporter family; Region: EamA; pfam00892 698936014422 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698936014423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936014424 DNA-binding site [nucleotide binding]; DNA binding site 698936014425 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936014426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936014427 homodimer interface [polypeptide binding]; other site 698936014428 catalytic residue [active] 698936014429 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 698936014430 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698936014431 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698936014432 shikimate binding site; other site 698936014433 NAD(P) binding site [chemical binding]; other site 698936014434 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 698936014435 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 698936014436 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 698936014437 DctM-like transporters; Region: DctM; pfam06808 698936014438 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 698936014439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936014440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936014441 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 698936014442 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698936014443 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698936014444 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 698936014445 Uncharacterized conserved protein [Function unknown]; Region: COG2128 698936014446 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698936014447 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 698936014448 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 698936014449 active site 698936014450 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 698936014451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 698936014452 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 698936014453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 698936014454 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698936014455 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698936014456 RNA binding surface [nucleotide binding]; other site 698936014457 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698936014458 active site 698936014459 5-oxoprolinase; Region: PLN02666 698936014460 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 698936014461 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 698936014462 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 698936014463 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698936014464 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936014465 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936014466 putative DNA binding site [nucleotide binding]; other site 698936014467 putative Zn2+ binding site [ion binding]; other site 698936014468 AsnC family; Region: AsnC_trans_reg; pfam01037 698936014469 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 698936014470 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 698936014471 tetramer interface [polypeptide binding]; other site 698936014472 TPP-binding site [chemical binding]; other site 698936014473 heterodimer interface [polypeptide binding]; other site 698936014474 phosphorylation loop region [posttranslational modification] 698936014475 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 698936014476 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 698936014477 alpha subunit interface [polypeptide binding]; other site 698936014478 TPP binding site [chemical binding]; other site 698936014479 heterodimer interface [polypeptide binding]; other site 698936014480 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698936014481 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 698936014482 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698936014483 E3 interaction surface; other site 698936014484 lipoyl attachment site [posttranslational modification]; other site 698936014485 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698936014486 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 698936014487 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698936014488 putative ligand binding site [chemical binding]; other site 698936014489 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936014490 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936014491 Walker A/P-loop; other site 698936014492 ATP binding site [chemical binding]; other site 698936014493 Q-loop/lid; other site 698936014494 ABC transporter signature motif; other site 698936014495 Walker B; other site 698936014496 D-loop; other site 698936014497 H-loop/switch region; other site 698936014498 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936014499 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936014500 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936014501 TM-ABC transporter signature motif; other site 698936014502 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936014503 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936014504 TM-ABC transporter signature motif; other site 698936014505 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936014506 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936014507 DNA binding site [nucleotide binding] 698936014508 domain linker motif; other site 698936014509 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 698936014510 dimerization interface [polypeptide binding]; other site 698936014511 ligand binding site [chemical binding]; other site 698936014512 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936014513 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936014514 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936014515 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 698936014516 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936014517 putative NAD(P) binding site [chemical binding]; other site 698936014518 active site 698936014519 putative substrate binding site [chemical binding]; other site 698936014520 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 698936014521 putative active site [active] 698936014522 redox center [active] 698936014523 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 698936014524 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698936014525 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936014526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936014527 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 698936014528 dimerization interface [polypeptide binding]; other site 698936014529 substrate binding pocket [chemical binding]; other site 698936014530 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 698936014531 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 698936014532 active site 698936014533 DNA binding site [nucleotide binding] 698936014534 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 698936014535 DNA binding site [nucleotide binding] 698936014536 hydroperoxidase II; Provisional; Region: katE; PRK11249 698936014537 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 698936014538 tetramer interface [polypeptide binding]; other site 698936014539 heme binding pocket [chemical binding]; other site 698936014540 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 698936014541 domain interactions; other site 698936014542 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576 698936014543 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 698936014544 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936014545 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 698936014546 putative C-terminal domain interface [polypeptide binding]; other site 698936014547 putative GSH binding site (G-site) [chemical binding]; other site 698936014548 putative dimer interface [polypeptide binding]; other site 698936014549 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 698936014550 putative N-terminal domain interface [polypeptide binding]; other site 698936014551 putative dimer interface [polypeptide binding]; other site 698936014552 putative substrate binding pocket (H-site) [chemical binding]; other site 698936014553 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936014554 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936014555 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 698936014556 putative effector binding pocket; other site 698936014557 putative dimerization interface [polypeptide binding]; other site 698936014558 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 698936014559 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698936014560 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936014561 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936014562 Walker A/P-loop; other site 698936014563 ATP binding site [chemical binding]; other site 698936014564 Q-loop/lid; other site 698936014565 ABC transporter signature motif; other site 698936014566 Walker B; other site 698936014567 D-loop; other site 698936014568 H-loop/switch region; other site 698936014569 TOBE domain; Region: TOBE_2; pfam08402 698936014570 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 698936014571 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 698936014572 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 698936014573 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 698936014574 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936014575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936014576 dimer interface [polypeptide binding]; other site 698936014577 conserved gate region; other site 698936014578 putative PBP binding loops; other site 698936014579 ABC-ATPase subunit interface; other site 698936014580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698936014581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936014582 putative PBP binding loops; other site 698936014583 ABC-ATPase subunit interface; other site 698936014584 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936014585 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936014586 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698936014587 oligomeric interface; other site 698936014588 putative active site [active] 698936014589 homodimer interface [polypeptide binding]; other site 698936014590 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936014591 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 698936014592 putative dimerization interface [polypeptide binding]; other site 698936014593 putative ligand binding site [chemical binding]; other site 698936014594 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698936014595 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936014596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936014597 alpha-galactosidase; Provisional; Region: PRK15076 698936014598 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 698936014599 NAD binding site [chemical binding]; other site 698936014600 sugar binding site [chemical binding]; other site 698936014601 divalent metal binding site [ion binding]; other site 698936014602 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 698936014603 dimer interface [polypeptide binding]; other site 698936014604 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 698936014605 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698936014606 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936014607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936014608 dimer interface [polypeptide binding]; other site 698936014609 conserved gate region; other site 698936014610 putative PBP binding loops; other site 698936014611 ABC-ATPase subunit interface; other site 698936014612 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698936014613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936014614 dimer interface [polypeptide binding]; other site 698936014615 conserved gate region; other site 698936014616 putative PBP binding loops; other site 698936014617 ABC-ATPase subunit interface; other site 698936014618 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 698936014619 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936014620 Walker A/P-loop; other site 698936014621 ATP binding site [chemical binding]; other site 698936014622 Q-loop/lid; other site 698936014623 ABC transporter signature motif; other site 698936014624 Walker B; other site 698936014625 D-loop; other site 698936014626 H-loop/switch region; other site 698936014627 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936014628 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936014629 Walker A/P-loop; other site 698936014630 ATP binding site [chemical binding]; other site 698936014631 Q-loop/lid; other site 698936014632 ABC transporter signature motif; other site 698936014633 Walker B; other site 698936014634 D-loop; other site 698936014635 H-loop/switch region; other site 698936014636 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936014637 alpha-galactosidase; Provisional; Region: PRK15076 698936014638 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 698936014639 NAD binding site [chemical binding]; other site 698936014640 sugar binding site [chemical binding]; other site 698936014641 divalent metal binding site [ion binding]; other site 698936014642 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 698936014643 dimer interface [polypeptide binding]; other site 698936014644 Protein of unknown function (DUF992); Region: DUF992; pfam06186 698936014645 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 698936014646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936014647 putative DNA binding site [nucleotide binding]; other site 698936014648 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 698936014649 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 698936014650 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 698936014651 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 698936014652 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 698936014653 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698936014654 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 698936014655 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 698936014656 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 698936014657 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 698936014658 FAD binding pocket [chemical binding]; other site 698936014659 FAD binding motif [chemical binding]; other site 698936014660 phosphate binding motif [ion binding]; other site 698936014661 beta-alpha-beta structure motif; other site 698936014662 NAD(p) ribose binding residues [chemical binding]; other site 698936014663 NAD binding pocket [chemical binding]; other site 698936014664 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 698936014665 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936014666 catalytic loop [active] 698936014667 iron binding site [ion binding]; other site 698936014668 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 698936014669 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 698936014670 substrate binding site [chemical binding]; other site 698936014671 dimer interface [polypeptide binding]; other site 698936014672 NADP binding site [chemical binding]; other site 698936014673 catalytic residues [active] 698936014674 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 698936014675 substrate binding site [chemical binding]; other site 698936014676 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 698936014677 enoyl-CoA hydratase; Provisional; Region: PRK08140 698936014678 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698936014679 substrate binding site [chemical binding]; other site 698936014680 oxyanion hole (OAH) forming residues; other site 698936014681 trimer interface [polypeptide binding]; other site 698936014682 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698936014683 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 698936014684 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 698936014685 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 698936014686 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 698936014687 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 698936014688 dimer interface [polypeptide binding]; other site 698936014689 active site 698936014690 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698936014691 catalytic residues [active] 698936014692 substrate binding site [chemical binding]; other site 698936014693 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 698936014694 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 698936014695 NAD(P) binding pocket [chemical binding]; other site 698936014696 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936014697 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936014698 DNA binding site [nucleotide binding] 698936014699 domain linker motif; other site 698936014700 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698936014701 dimerization interface [polypeptide binding]; other site 698936014702 ligand binding site [chemical binding]; other site 698936014703 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936014704 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936014705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936014706 dimer interface [polypeptide binding]; other site 698936014707 conserved gate region; other site 698936014708 putative PBP binding loops; other site 698936014709 ABC-ATPase subunit interface; other site 698936014710 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936014711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936014712 dimer interface [polypeptide binding]; other site 698936014713 conserved gate region; other site 698936014714 putative PBP binding loops; other site 698936014715 ABC-ATPase subunit interface; other site 698936014716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 698936014717 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 698936014718 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936014719 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936014720 Walker A/P-loop; other site 698936014721 ATP binding site [chemical binding]; other site 698936014722 Q-loop/lid; other site 698936014723 ABC transporter signature motif; other site 698936014724 Walker B; other site 698936014725 D-loop; other site 698936014726 H-loop/switch region; other site 698936014727 TOBE domain; Region: TOBE_2; pfam08402 698936014728 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 698936014729 Predicted transcriptional regulator [Transcription]; Region: COG3905 698936014730 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 698936014731 Cupin; Region: Cupin_6; pfam12852 698936014732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936014733 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936014734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936014735 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698936014736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936014737 putative substrate translocation pore; other site 698936014738 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698936014739 thiamine phosphate binding site [chemical binding]; other site 698936014740 active site 698936014741 pyrophosphate binding site [ion binding]; other site 698936014742 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698936014743 ThiS interaction site; other site 698936014744 putative active site [active] 698936014745 tetramer interface [polypeptide binding]; other site 698936014746 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 698936014747 thiS-thiF/thiG interaction site; other site 698936014748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698936014749 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698936014750 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698936014751 ThiC-associated domain; Region: ThiC-associated; pfam13667 698936014752 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 698936014753 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 698936014754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936014755 active site 698936014756 phosphorylation site [posttranslational modification] 698936014757 intermolecular recognition site; other site 698936014758 dimerization interface [polypeptide binding]; other site 698936014759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936014760 Walker A motif; other site 698936014761 ATP binding site [chemical binding]; other site 698936014762 Walker B motif; other site 698936014763 arginine finger; other site 698936014764 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 698936014765 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 698936014766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936014767 dimer interface [polypeptide binding]; other site 698936014768 phosphorylation site [posttranslational modification] 698936014769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936014770 ATP binding site [chemical binding]; other site 698936014771 Mg2+ binding site [ion binding]; other site 698936014772 G-X-G motif; other site 698936014773 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 698936014774 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698936014775 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698936014776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936014777 active site 698936014778 phosphorylation site [posttranslational modification] 698936014779 intermolecular recognition site; other site 698936014780 dimerization interface [polypeptide binding]; other site 698936014781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936014782 DNA binding residues [nucleotide binding] 698936014783 dimerization interface [polypeptide binding]; other site 698936014784 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 698936014785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936014786 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936014787 dimer interface [polypeptide binding]; other site 698936014788 phosphorylation site [posttranslational modification] 698936014789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936014790 ATP binding site [chemical binding]; other site 698936014791 Mg2+ binding site [ion binding]; other site 698936014792 G-X-G motif; other site 698936014793 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698936014794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936014795 active site 698936014796 phosphorylation site [posttranslational modification] 698936014797 intermolecular recognition site; other site 698936014798 dimerization interface [polypeptide binding]; other site 698936014799 Sterile alpha motif; Region: SAM; smart00454 698936014800 SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487 698936014801 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 698936014802 cyclase homology domain; Region: CHD; cd07302 698936014803 nucleotidyl binding site; other site 698936014804 metal binding site [ion binding]; metal-binding site 698936014805 dimer interface [polypeptide binding]; other site 698936014806 AAA ATPase domain; Region: AAA_16; pfam13191 698936014807 SnoaL-like domain; Region: SnoaL_4; cl17707 698936014808 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936014809 dimerization interface [polypeptide binding]; other site 698936014810 putative DNA binding site [nucleotide binding]; other site 698936014811 putative Zn2+ binding site [ion binding]; other site 698936014812 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 698936014813 putative hydrophobic ligand binding site [chemical binding]; other site 698936014814 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698936014815 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 698936014816 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 698936014817 putative ligand binding site [chemical binding]; other site 698936014818 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 698936014819 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936014820 TM-ABC transporter signature motif; other site 698936014821 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 698936014822 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 698936014823 TM-ABC transporter signature motif; other site 698936014824 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 698936014825 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 698936014826 Walker A/P-loop; other site 698936014827 ATP binding site [chemical binding]; other site 698936014828 Q-loop/lid; other site 698936014829 ABC transporter signature motif; other site 698936014830 Walker B; other site 698936014831 D-loop; other site 698936014832 H-loop/switch region; other site 698936014833 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 698936014834 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 698936014835 Walker A/P-loop; other site 698936014836 ATP binding site [chemical binding]; other site 698936014837 Q-loop/lid; other site 698936014838 ABC transporter signature motif; other site 698936014839 Walker B; other site 698936014840 D-loop; other site 698936014841 H-loop/switch region; other site 698936014842 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 698936014843 ParB-like nuclease domain; Region: ParBc; pfam02195 698936014844 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 698936014845 MerR family regulatory protein; Region: MerR; pfam00376 698936014846 DNA binding residues [nucleotide binding] 698936014847 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698936014848 P-loop; other site 698936014849 Magnesium ion binding site [ion binding]; other site 698936014850 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 698936014851 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698936014852 Magnesium ion binding site [ion binding]; other site 698936014853 Predicted membrane protein [Function unknown]; Region: COG2259 698936014854 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698936014855 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698936014856 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698936014857 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 698936014858 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 698936014859 Predicted outer membrane protein [Function unknown]; Region: COG3652 698936014860 RNA polymerase sigma factor; Provisional; Region: PRK11922 698936014861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698936014862 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936014863 DNA binding residues [nucleotide binding] 698936014864 acylphosphatase; Provisional; Region: PRK14425 698936014865 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 698936014866 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698936014867 dimer interface [polypeptide binding]; other site 698936014868 active site 698936014869 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 698936014870 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 698936014871 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 698936014872 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 698936014873 Bacterial transcriptional regulator; Region: IclR; pfam01614 698936014874 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 698936014875 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 698936014876 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 698936014877 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 698936014878 Moco binding site; other site 698936014879 metal coordination site [ion binding]; other site 698936014880 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 698936014881 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936014882 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936014883 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 698936014884 putative dimerization interface [polypeptide binding]; other site 698936014885 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936014886 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 698936014887 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 698936014888 dimer interface [polypeptide binding]; other site 698936014889 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 698936014890 active site 698936014891 Fe binding site [ion binding]; other site 698936014892 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 698936014893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936014894 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936014895 dimerization interface [polypeptide binding]; other site 698936014896 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936014897 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 698936014898 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 698936014899 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 698936014900 heterodimer interface [polypeptide binding]; other site 698936014901 multimer interface [polypeptide binding]; other site 698936014902 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 698936014903 active site 698936014904 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 698936014905 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 698936014906 heterodimer interface [polypeptide binding]; other site 698936014907 active site 698936014908 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975 698936014909 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 698936014910 tetramer interface [polypeptide binding]; other site 698936014911 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 698936014912 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698936014913 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 698936014914 active site 698936014915 catalytic site [active] 698936014916 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698936014917 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 698936014918 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 698936014919 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 698936014920 active site 698936014921 non-prolyl cis peptide bond; other site 698936014922 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698936014923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936014924 dimer interface [polypeptide binding]; other site 698936014925 conserved gate region; other site 698936014926 putative PBP binding loops; other site 698936014927 ABC-ATPase subunit interface; other site 698936014928 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 698936014929 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936014930 substrate binding pocket [chemical binding]; other site 698936014931 membrane-bound complex binding site; other site 698936014932 hinge residues; other site 698936014933 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698936014934 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698936014935 Walker A/P-loop; other site 698936014936 ATP binding site [chemical binding]; other site 698936014937 Q-loop/lid; other site 698936014938 ABC transporter signature motif; other site 698936014939 Walker B; other site 698936014940 D-loop; other site 698936014941 H-loop/switch region; other site 698936014942 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 698936014943 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698936014944 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 698936014945 TM-ABC transporter signature motif; other site 698936014946 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 698936014947 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936014948 TM-ABC transporter signature motif; other site 698936014949 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698936014950 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 698936014951 Walker A/P-loop; other site 698936014952 ATP binding site [chemical binding]; other site 698936014953 Q-loop/lid; other site 698936014954 ABC transporter signature motif; other site 698936014955 Walker B; other site 698936014956 D-loop; other site 698936014957 H-loop/switch region; other site 698936014958 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 698936014959 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 698936014960 Walker A/P-loop; other site 698936014961 ATP binding site [chemical binding]; other site 698936014962 Q-loop/lid; other site 698936014963 ABC transporter signature motif; other site 698936014964 Walker B; other site 698936014965 D-loop; other site 698936014966 H-loop/switch region; other site 698936014967 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 698936014968 CHASE2 domain; Region: CHASE2; pfam05226 698936014969 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936014970 cyclase homology domain; Region: CHD; cd07302 698936014971 nucleotidyl binding site; other site 698936014972 metal binding site [ion binding]; metal-binding site 698936014973 dimer interface [polypeptide binding]; other site 698936014974 FecR protein; Region: FecR; pfam04773 698936014975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936014976 TPR motif; other site 698936014977 TPR repeat; Region: TPR_11; pfam13414 698936014978 binding surface 698936014979 TPR repeat; Region: TPR_11; pfam13414 698936014980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936014981 binding surface 698936014982 TPR motif; other site 698936014983 TPR repeat; Region: TPR_11; pfam13414 698936014984 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936014985 binding surface 698936014986 TPR motif; other site 698936014987 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 698936014988 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936014989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936014990 DNA-binding site [nucleotide binding]; DNA binding site 698936014991 FCD domain; Region: FCD; pfam07729 698936014992 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 698936014993 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 698936014994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 698936014995 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 698936014996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 698936014997 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 698936014998 dihydroxyacetone kinase; Provisional; Region: PRK14479 698936014999 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 698936015000 DAK2 domain; Region: Dak2; pfam02734 698936015001 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 698936015002 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 698936015003 trimer interface [polypeptide binding]; other site 698936015004 active site 698936015005 substrate binding site [chemical binding]; other site 698936015006 CoA binding site [chemical binding]; other site 698936015007 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 698936015008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936015009 Walker A/P-loop; other site 698936015010 ATP binding site [chemical binding]; other site 698936015011 Q-loop/lid; other site 698936015012 ABC transporter signature motif; other site 698936015013 Walker B; other site 698936015014 D-loop; other site 698936015015 H-loop/switch region; other site 698936015016 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 698936015017 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936015018 Walker A/P-loop; other site 698936015019 ATP binding site [chemical binding]; other site 698936015020 Q-loop/lid; other site 698936015021 ABC transporter signature motif; other site 698936015022 Walker B; other site 698936015023 D-loop; other site 698936015024 H-loop/switch region; other site 698936015025 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936015026 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 698936015027 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 698936015028 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 698936015029 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 698936015030 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 698936015031 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936015032 DNA-binding site [nucleotide binding]; DNA binding site 698936015033 UTRA domain; Region: UTRA; pfam07702 698936015034 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 698936015035 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 698936015036 active site 698936015037 substrate binding site [chemical binding]; other site 698936015038 coenzyme B12 binding site [chemical binding]; other site 698936015039 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 698936015040 B12 binding site [chemical binding]; other site 698936015041 cobalt ligand [ion binding]; other site 698936015042 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698936015043 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698936015044 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698936015045 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698936015046 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698936015047 carboxyltransferase (CT) interaction site; other site 698936015048 biotinylation site [posttranslational modification]; other site 698936015049 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698936015050 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698936015051 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698936015052 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698936015053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936015054 non-specific DNA binding site [nucleotide binding]; other site 698936015055 salt bridge; other site 698936015056 sequence-specific DNA binding site [nucleotide binding]; other site 698936015057 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698936015058 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698936015059 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698936015060 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698936015061 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 698936015062 substrate binding pocket [chemical binding]; other site 698936015063 FAD binding site [chemical binding]; other site 698936015064 catalytic base [active] 698936015065 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 698936015066 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698936015067 substrate binding site [chemical binding]; other site 698936015068 oxyanion hole (OAH) forming residues; other site 698936015069 trimer interface [polypeptide binding]; other site 698936015070 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698936015071 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698936015072 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 698936015073 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 698936015074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936015075 NAD(P) binding site [chemical binding]; other site 698936015076 active site 698936015077 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 698936015078 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 698936015079 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 698936015080 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698936015081 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 698936015082 active site 698936015083 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698936015084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936015085 motif II; other site 698936015086 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 698936015087 glutamine synthetase; Region: PLN02284 698936015088 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698936015089 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698936015090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 698936015091 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 698936015092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 698936015093 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698936015094 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698936015095 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698936015096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936015097 active site 698936015098 phosphorylation site [posttranslational modification] 698936015099 intermolecular recognition site; other site 698936015100 dimerization interface [polypeptide binding]; other site 698936015101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936015102 DNA binding site [nucleotide binding] 698936015103 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 698936015104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936015105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936015106 dimer interface [polypeptide binding]; other site 698936015107 phosphorylation site [posttranslational modification] 698936015108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936015109 ATP binding site [chemical binding]; other site 698936015110 Mg2+ binding site [ion binding]; other site 698936015111 G-X-G motif; other site 698936015112 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936015113 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 698936015114 putative ligand binding site [chemical binding]; other site 698936015115 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936015116 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936015117 TM-ABC transporter signature motif; other site 698936015118 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936015119 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936015120 Walker A/P-loop; other site 698936015121 ATP binding site [chemical binding]; other site 698936015122 Q-loop/lid; other site 698936015123 ABC transporter signature motif; other site 698936015124 Walker B; other site 698936015125 D-loop; other site 698936015126 H-loop/switch region; other site 698936015127 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936015128 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936015129 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936015130 DNA binding site [nucleotide binding] 698936015131 domain linker motif; other site 698936015132 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 698936015133 dimerization interface [polypeptide binding]; other site 698936015134 ligand binding site [chemical binding]; other site 698936015135 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 698936015136 EamA-like transporter family; Region: EamA; pfam00892 698936015137 EamA-like transporter family; Region: EamA; pfam00892 698936015138 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936015139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936015140 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698936015141 dimerization interface [polypeptide binding]; other site 698936015142 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936015143 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936015144 TM-ABC transporter signature motif; other site 698936015145 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936015146 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936015147 Walker A/P-loop; other site 698936015148 ATP binding site [chemical binding]; other site 698936015149 Q-loop/lid; other site 698936015150 ABC transporter signature motif; other site 698936015151 Walker B; other site 698936015152 D-loop; other site 698936015153 H-loop/switch region; other site 698936015154 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936015155 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936015156 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 698936015157 putative ligand binding site [chemical binding]; other site 698936015158 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 698936015159 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 698936015160 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698936015161 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698936015162 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 698936015163 active site 698936015164 DNA binding site [nucleotide binding] 698936015165 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 698936015166 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698936015167 DNA binding site [nucleotide binding] 698936015168 active site 698936015169 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936015170 cyclase homology domain; Region: CHD; cd07302 698936015171 nucleotidyl binding site; other site 698936015172 metal binding site [ion binding]; metal-binding site 698936015173 dimer interface [polypeptide binding]; other site 698936015174 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 698936015175 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936015176 substrate binding pocket [chemical binding]; other site 698936015177 membrane-bound complex binding site; other site 698936015178 hinge residues; other site 698936015179 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698936015180 EamA-like transporter family; Region: EamA; pfam00892 698936015181 glycogen synthase; Provisional; Region: glgA; PRK00654 698936015182 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 698936015183 ADP-binding pocket [chemical binding]; other site 698936015184 homodimer interface [polypeptide binding]; other site 698936015185 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698936015186 substrate binding site [chemical binding]; other site 698936015187 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698936015188 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936015189 DNA binding site [nucleotide binding] 698936015190 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936015191 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 698936015192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936015193 TPR motif; other site 698936015194 binding surface 698936015195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936015196 binding surface 698936015197 TPR motif; other site 698936015198 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698936015199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936015200 NAD(P) binding site [chemical binding]; other site 698936015201 active site 698936015202 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 698936015203 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 698936015204 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936015205 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936015206 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698936015207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936015208 putative substrate translocation pore; other site 698936015209 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 698936015210 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 698936015211 Uncharacterized conserved protein [Function unknown]; Region: COG5642 698936015212 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 698936015213 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 698936015214 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698936015215 NADP binding site [chemical binding]; other site 698936015216 homodimer interface [polypeptide binding]; other site 698936015217 active site 698936015218 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 698936015219 putative catalytic site [active] 698936015220 putative phosphate binding site [ion binding]; other site 698936015221 active site 698936015222 metal binding site A [ion binding]; metal-binding site 698936015223 DNA binding site [nucleotide binding] 698936015224 putative AP binding site [nucleotide binding]; other site 698936015225 putative metal binding site B [ion binding]; other site 698936015226 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 698936015227 TPR repeat; Region: TPR_11; pfam13414 698936015228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936015229 binding surface 698936015230 TPR motif; other site 698936015231 TPR repeat; Region: TPR_11; pfam13414 698936015232 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 698936015233 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 698936015234 putative DNA binding site [nucleotide binding]; other site 698936015235 putative homodimer interface [polypeptide binding]; other site 698936015236 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 698936015237 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 698936015238 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 698936015239 active site 698936015240 DNA binding site [nucleotide binding] 698936015241 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 698936015242 DNA binding site [nucleotide binding] 698936015243 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 698936015244 nucleotide binding site [chemical binding]; other site 698936015245 hypothetical protein; Provisional; Region: PRK11171 698936015246 Cupin domain; Region: Cupin_2; pfam07883 698936015247 Cupin domain; Region: Cupin_2; pfam07883 698936015248 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 698936015249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936015250 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 698936015251 putative dimerization interface [polypeptide binding]; other site 698936015252 putative substrate binding pocket [chemical binding]; other site 698936015253 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 698936015254 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698936015255 Bacterial transcriptional regulator; Region: IclR; pfam01614 698936015256 glyoxylate carboligase; Provisional; Region: PRK11269 698936015257 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698936015258 PYR/PP interface [polypeptide binding]; other site 698936015259 dimer interface [polypeptide binding]; other site 698936015260 TPP binding site [chemical binding]; other site 698936015261 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698936015262 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 698936015263 TPP-binding site [chemical binding]; other site 698936015264 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 698936015265 tartronate semialdehyde reductase; Provisional; Region: PRK15059 698936015266 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698936015267 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 698936015268 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 698936015269 MOFRL family; Region: MOFRL; pfam05161 698936015270 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 698936015271 ureidoglycolate hydrolase; Provisional; Region: PRK13395 698936015272 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 698936015273 Uncharacterized conserved protein [Function unknown]; Region: COG3506 698936015274 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936015275 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936015276 DNA binding site [nucleotide binding] 698936015277 domain linker motif; other site 698936015278 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698936015279 dimerization interface [polypeptide binding]; other site 698936015280 ligand binding site [chemical binding]; other site 698936015281 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936015282 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936015283 Walker A/P-loop; other site 698936015284 ATP binding site [chemical binding]; other site 698936015285 Q-loop/lid; other site 698936015286 ABC transporter signature motif; other site 698936015287 Walker B; other site 698936015288 D-loop; other site 698936015289 H-loop/switch region; other site 698936015290 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936015291 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 698936015292 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936015293 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936015294 TM-ABC transporter signature motif; other site 698936015295 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936015296 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 698936015297 putative ligand binding site [chemical binding]; other site 698936015298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 698936015299 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 698936015300 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698936015301 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698936015302 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936015303 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936015304 DNA binding site [nucleotide binding] 698936015305 domain linker motif; other site 698936015306 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 698936015307 putative dimerization interface [polypeptide binding]; other site 698936015308 putative ligand binding site [chemical binding]; other site 698936015309 putative aldolase; Validated; Region: PRK08130 698936015310 intersubunit interface [polypeptide binding]; other site 698936015311 active site 698936015312 Zn2+ binding site [ion binding]; other site 698936015313 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936015314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936015315 DNA-binding site [nucleotide binding]; DNA binding site 698936015316 FCD domain; Region: FCD; pfam07729 698936015317 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936015318 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 698936015319 putative NAD(P) binding site [chemical binding]; other site 698936015320 active site 698936015321 putative substrate binding site [chemical binding]; other site 698936015322 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936015323 classical (c) SDRs; Region: SDR_c; cd05233 698936015324 NAD(P) binding site [chemical binding]; other site 698936015325 active site 698936015326 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698936015327 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936015328 Walker A/P-loop; other site 698936015329 ATP binding site [chemical binding]; other site 698936015330 Q-loop/lid; other site 698936015331 ABC transporter signature motif; other site 698936015332 Walker B; other site 698936015333 D-loop; other site 698936015334 H-loop/switch region; other site 698936015335 TOBE domain; Region: TOBE; pfam03459 698936015336 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936015337 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936015338 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936015339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936015340 dimer interface [polypeptide binding]; other site 698936015341 conserved gate region; other site 698936015342 putative PBP binding loops; other site 698936015343 ABC-ATPase subunit interface; other site 698936015344 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936015345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936015346 dimer interface [polypeptide binding]; other site 698936015347 conserved gate region; other site 698936015348 putative PBP binding loops; other site 698936015349 ABC-ATPase subunit interface; other site 698936015350 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936015351 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936015352 active site 698936015353 catalytic tetrad [active] 698936015354 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 698936015355 dimer interface [polypeptide binding]; other site 698936015356 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 698936015357 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698936015358 active site 698936015359 dimer interface [polypeptide binding]; other site 698936015360 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698936015361 Ligand Binding Site [chemical binding]; other site 698936015362 Molecular Tunnel; other site 698936015363 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 698936015364 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 698936015365 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698936015366 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 698936015367 acyl-activating enzyme (AAE) consensus motif; other site 698936015368 putative AMP binding site [chemical binding]; other site 698936015369 putative active site [active] 698936015370 putative CoA binding site [chemical binding]; other site 698936015371 NAD synthetase; Reviewed; Region: nadE; PRK00876 698936015372 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698936015373 homodimer interface [polypeptide binding]; other site 698936015374 NAD binding pocket [chemical binding]; other site 698936015375 ATP binding pocket [chemical binding]; other site 698936015376 Mg binding site [ion binding]; other site 698936015377 active-site loop [active] 698936015378 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936015379 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936015380 active site 698936015381 catalytic tetrad [active] 698936015382 septum formation inhibitor; Reviewed; Region: minC; PRK05177 698936015383 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 698936015384 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 698936015385 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 698936015386 Switch I; other site 698936015387 Switch II; other site 698936015388 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 698936015389 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936015390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936015391 active site 698936015392 phosphorylation site [posttranslational modification] 698936015393 intermolecular recognition site; other site 698936015394 dimerization interface [polypeptide binding]; other site 698936015395 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936015396 DNA binding residues [nucleotide binding] 698936015397 dimerization interface [polypeptide binding]; other site 698936015398 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698936015399 Histidine kinase; Region: HisKA_3; pfam07730 698936015400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936015401 ATP binding site [chemical binding]; other site 698936015402 Mg2+ binding site [ion binding]; other site 698936015403 G-X-G motif; other site 698936015404 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698936015405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698936015406 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698936015407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698936015408 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 698936015409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936015410 S-adenosylmethionine binding site [chemical binding]; other site 698936015411 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 698936015412 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698936015413 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698936015414 inhibitor site; inhibition site 698936015415 active site 698936015416 dimer interface [polypeptide binding]; other site 698936015417 catalytic residue [active] 698936015418 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698936015419 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 698936015420 Chain length determinant protein; Region: Wzz; cl15801 698936015421 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 698936015422 O-Antigen ligase; Region: Wzy_C; pfam04932 698936015423 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698936015424 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 698936015425 putative active site [active] 698936015426 putative metal binding site [ion binding]; other site 698936015427 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936015428 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698936015429 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936015430 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 698936015431 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698936015432 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698936015433 active site 698936015434 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698936015435 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698936015436 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936015437 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936015438 ornithine cyclodeaminase; Validated; Region: PRK07589 698936015439 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 698936015440 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936015441 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 698936015442 putative DNA binding site [nucleotide binding]; other site 698936015443 putative Zn2+ binding site [ion binding]; other site 698936015444 AsnC family; Region: AsnC_trans_reg; pfam01037 698936015445 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664 698936015446 Protein of unknown function (DUF992); Region: DUF992; pfam06186 698936015447 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698936015448 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 698936015449 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 698936015450 Subunit I/III interface [polypeptide binding]; other site 698936015451 Subunit III/IV interface [polypeptide binding]; other site 698936015452 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698936015453 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698936015454 D-pathway; other site 698936015455 Putative ubiquinol binding site [chemical binding]; other site 698936015456 Low-spin heme (heme b) binding site [chemical binding]; other site 698936015457 Putative water exit pathway; other site 698936015458 Binuclear center (heme o3/CuB) [ion binding]; other site 698936015459 K-pathway; other site 698936015460 Putative proton exit pathway; other site 698936015461 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 698936015462 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698936015463 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 698936015464 metabolite-proton symporter; Region: 2A0106; TIGR00883 698936015465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936015466 putative substrate translocation pore; other site 698936015467 RNA polymerase sigma factor; Provisional; Region: PRK12547 698936015468 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698936015469 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936015470 DNA binding residues [nucleotide binding] 698936015471 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 698936015472 FOG: CBS domain [General function prediction only]; Region: COG0517 698936015473 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 698936015474 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698936015475 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 698936015476 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 698936015477 putative active site [active] 698936015478 putative NTP binding site [chemical binding]; other site 698936015479 putative nucleic acid binding site [nucleotide binding]; other site 698936015480 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 698936015481 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936015482 classical (c) SDRs; Region: SDR_c; cd05233 698936015483 NAD(P) binding site [chemical binding]; other site 698936015484 active site 698936015485 Predicted small integral membrane protein [Function unknown]; Region: COG5478 698936015486 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698936015487 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698936015488 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698936015489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 698936015490 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 698936015491 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698936015492 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 698936015493 Walker A/P-loop; other site 698936015494 ATP binding site [chemical binding]; other site 698936015495 Q-loop/lid; other site 698936015496 ABC transporter signature motif; other site 698936015497 Walker B; other site 698936015498 D-loop; other site 698936015499 H-loop/switch region; other site 698936015500 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 698936015501 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936015502 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936015503 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698936015504 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936015505 DNA-binding site [nucleotide binding]; DNA binding site 698936015506 UTRA domain; Region: UTRA; pfam07702 698936015507 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 698936015508 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 698936015509 NAD binding site [chemical binding]; other site 698936015510 sugar binding site [chemical binding]; other site 698936015511 divalent metal binding site [ion binding]; other site 698936015512 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698936015513 dimer interface [polypeptide binding]; other site 698936015514 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698936015515 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 698936015516 substrate binding site [chemical binding]; other site 698936015517 ATP binding site [chemical binding]; other site 698936015518 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936015519 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936015520 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698936015521 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936015522 Walker A/P-loop; other site 698936015523 ATP binding site [chemical binding]; other site 698936015524 Q-loop/lid; other site 698936015525 ABC transporter signature motif; other site 698936015526 Walker B; other site 698936015527 D-loop; other site 698936015528 H-loop/switch region; other site 698936015529 TOBE domain; Region: TOBE_2; pfam08402 698936015530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936015531 dimer interface [polypeptide binding]; other site 698936015532 conserved gate region; other site 698936015533 putative PBP binding loops; other site 698936015534 ABC-ATPase subunit interface; other site 698936015535 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936015536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936015537 dimer interface [polypeptide binding]; other site 698936015538 conserved gate region; other site 698936015539 putative PBP binding loops; other site 698936015540 ABC-ATPase subunit interface; other site 698936015541 Uncharacterized conserved protein [Function unknown]; Region: COG1415 698936015542 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 698936015543 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 698936015544 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 698936015545 glutathione s-transferase; Provisional; Region: PTZ00057 698936015546 GSH binding site (G-site) [chemical binding]; other site 698936015547 C-terminal domain interface [polypeptide binding]; other site 698936015548 dimer interface [polypeptide binding]; other site 698936015549 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 698936015550 N-terminal domain interface [polypeptide binding]; other site 698936015551 substrate binding pocket (H-site) [chemical binding]; other site 698936015552 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 698936015553 Fe-S cluster binding site [ion binding]; other site 698936015554 active site 698936015555 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 698936015556 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 698936015557 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 698936015558 catalytic site [active] 698936015559 active site 698936015560 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 698936015561 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698936015562 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698936015563 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698936015564 active site 698936015565 catalytic site [active] 698936015566 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 698936015567 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 698936015568 active site 698936015569 DNA binding site [nucleotide binding] 698936015570 Int/Topo IB signature motif; other site 698936015571 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 698936015572 BON domain; Region: BON; pfam04972 698936015573 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 698936015574 FOG: CBS domain [General function prediction only]; Region: COG0517 698936015575 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 698936015576 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 698936015577 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698936015578 homotrimer interaction site [polypeptide binding]; other site 698936015579 putative active site [active] 698936015580 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 698936015581 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 698936015582 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 698936015583 DctM-like transporters; Region: DctM; pfam06808 698936015584 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 698936015585 allantoate amidohydrolase; Reviewed; Region: PRK12893 698936015586 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 698936015587 active site 698936015588 metal binding site [ion binding]; metal-binding site 698936015589 dimer interface [polypeptide binding]; other site 698936015590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936015591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936015592 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698936015593 dimerization interface [polypeptide binding]; other site 698936015594 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698936015595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936015596 S-adenosylmethionine binding site [chemical binding]; other site 698936015597 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698936015598 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698936015599 putative ligand binding residues [chemical binding]; other site 698936015600 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698936015601 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698936015602 ABC-ATPase subunit interface; other site 698936015603 dimer interface [polypeptide binding]; other site 698936015604 putative PBP binding regions; other site 698936015605 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698936015606 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698936015607 Walker A/P-loop; other site 698936015608 ATP binding site [chemical binding]; other site 698936015609 Q-loop/lid; other site 698936015610 ABC transporter signature motif; other site 698936015611 Walker B; other site 698936015612 D-loop; other site 698936015613 H-loop/switch region; other site 698936015614 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 698936015615 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698936015616 putative trimer interface [polypeptide binding]; other site 698936015617 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698936015618 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 698936015619 trimer interface [polypeptide binding]; other site 698936015620 active site 698936015621 substrate binding site [chemical binding]; other site 698936015622 putative CoA binding site [chemical binding]; other site 698936015623 CoA binding site [chemical binding]; other site 698936015624 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 698936015625 extended (e) SDRs; Region: SDR_e; cd08946 698936015626 NAD(P) binding site [chemical binding]; other site 698936015627 active site 698936015628 substrate binding site [chemical binding]; other site 698936015629 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 698936015630 Predicted acyl esterases [General function prediction only]; Region: COG2936 698936015631 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 698936015632 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936015633 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936015634 TM-ABC transporter signature motif; other site 698936015635 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936015636 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936015637 Walker A/P-loop; other site 698936015638 ATP binding site [chemical binding]; other site 698936015639 Q-loop/lid; other site 698936015640 ABC transporter signature motif; other site 698936015641 Walker B; other site 698936015642 D-loop; other site 698936015643 H-loop/switch region; other site 698936015644 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936015645 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936015646 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 698936015647 ligand binding site [chemical binding]; other site 698936015648 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 698936015649 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 698936015650 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698936015651 substrate binding site [chemical binding]; other site 698936015652 trimer interface [polypeptide binding]; other site 698936015653 Mn binding site [ion binding]; other site 698936015654 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698936015655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936015656 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936015657 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936015658 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 698936015659 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698936015660 Methyltransferase domain; Region: Methyltransf_12; pfam08242 698936015661 S-adenosylmethionine binding site [chemical binding]; other site 698936015662 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 698936015663 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 698936015664 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 698936015665 NAD binding site [chemical binding]; other site 698936015666 homotetramer interface [polypeptide binding]; other site 698936015667 homodimer interface [polypeptide binding]; other site 698936015668 substrate binding site [chemical binding]; other site 698936015669 active site 698936015670 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698936015671 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 698936015672 substrate binding site; other site 698936015673 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698936015674 FAD binding domain; Region: FAD_binding_4; pfam01565 698936015675 Berberine and berberine like; Region: BBE; pfam08031 698936015676 tyrosine decarboxylase; Region: PLN02880 698936015677 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 698936015678 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698936015679 catalytic residue [active] 698936015680 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 698936015681 Ca2+ binding site [ion binding]; other site 698936015682 Protein of unknown function, DUF488; Region: DUF488; cl01246 698936015683 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698936015684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936015685 S-adenosylmethionine binding site [chemical binding]; other site 698936015686 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 698936015687 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 698936015688 putative DNA binding site [nucleotide binding]; other site 698936015689 putative homodimer interface [polypeptide binding]; other site 698936015690 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 698936015691 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 698936015692 putative DNA binding site [nucleotide binding]; other site 698936015693 putative homodimer interface [polypeptide binding]; other site 698936015694 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 698936015695 catalytic triad [active] 698936015696 dimer interface [polypeptide binding]; other site 698936015697 conserved cis-peptide bond; other site 698936015698 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698936015699 MULE transposase domain; Region: MULE; pfam10551 698936015700 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 698936015701 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 698936015702 Homeodomain-like domain; Region: HTH_32; pfam13565 698936015703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698936015704 Integrase core domain; Region: rve; pfam00665 698936015705 Integrase core domain; Region: rve_3; pfam13683 698936015706 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 698936015707 GIY-YIG motif/motif A; other site 698936015708 putative active site [active] 698936015709 catalytic site [active] 698936015710 putative metal binding site [ion binding]; other site 698936015711 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 698936015712 catalytic residues [active] 698936015713 N-terminal catalytic GIY-YIG domain of bacteriophage T4 segABCDEFG gene encoding proteins; Region: GIY-YIG_SegABCDEFG; cd10444 698936015714 GIY-YIG motif/motif A; other site 698936015715 putative active site [active] 698936015716 putative metal binding site [ion binding]; other site 698936015717 Terminase-like family; Region: Terminase_6; pfam03237 698936015718 multiple promoter invertase; Provisional; Region: mpi; PRK13413 698936015719 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698936015720 catalytic residues [active] 698936015721 catalytic nucleophile [active] 698936015722 Presynaptic Site I dimer interface [polypeptide binding]; other site 698936015723 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698936015724 Synaptic Flat tetramer interface [polypeptide binding]; other site 698936015725 Synaptic Site I dimer interface [polypeptide binding]; other site 698936015726 DNA binding site [nucleotide binding] 698936015727 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698936015728 DNA-binding interface [nucleotide binding]; DNA binding site 698936015729 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 698936015730 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698936015731 active site 698936015732 catalytic residues [active] 698936015733 DNA binding site [nucleotide binding] 698936015734 Int/Topo IB signature motif; other site 698936015735 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698936015736 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936015737 Walker A/P-loop; other site 698936015738 ATP binding site [chemical binding]; other site 698936015739 Q-loop/lid; other site 698936015740 ABC transporter signature motif; other site 698936015741 Walker B; other site 698936015742 D-loop; other site 698936015743 H-loop/switch region; other site 698936015744 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936015745 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936015746 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936015747 TM-ABC transporter signature motif; other site 698936015748 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 698936015749 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 698936015750 putative ligand binding site [chemical binding]; other site 698936015751 Predicted esterase [General function prediction only]; Region: COG0400 698936015752 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 698936015753 putative active site [active] 698936015754 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 698936015755 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 698936015756 acetylornithine deacetylase; Provisional; Region: PRK07522 698936015757 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 698936015758 metal binding site [ion binding]; metal-binding site 698936015759 putative dimer interface [polypeptide binding]; other site 698936015760 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 698936015761 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698936015762 putative ligand binding site [chemical binding]; other site 698936015763 NAD binding site [chemical binding]; other site 698936015764 dimerization interface [polypeptide binding]; other site 698936015765 catalytic site [active] 698936015766 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 698936015767 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698936015768 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698936015769 NAD(P) binding site [chemical binding]; other site 698936015770 catalytic residues [active] 698936015771 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 698936015772 tartrate dehydrogenase; Region: TTC; TIGR02089 698936015773 succinic semialdehyde dehydrogenase; Region: PLN02278 698936015774 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698936015775 tetramerization interface [polypeptide binding]; other site 698936015776 NAD(P) binding site [chemical binding]; other site 698936015777 catalytic residues [active] 698936015778 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698936015779 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936015780 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 698936015781 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 698936015782 putative acetyltransferase; Provisional; Region: PRK03624 698936015783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936015784 Coenzyme A binding pocket [chemical binding]; other site 698936015785 hypothetical protein; Provisional; Region: PRK05965 698936015786 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698936015787 inhibitor-cofactor binding pocket; inhibition site 698936015788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936015789 catalytic residue [active] 698936015790 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 698936015791 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 698936015792 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936015793 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698936015794 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936015795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936015796 dimer interface [polypeptide binding]; other site 698936015797 conserved gate region; other site 698936015798 putative PBP binding loops; other site 698936015799 ABC-ATPase subunit interface; other site 698936015800 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698936015801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936015802 dimer interface [polypeptide binding]; other site 698936015803 conserved gate region; other site 698936015804 ABC-ATPase subunit interface; other site 698936015805 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698936015806 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936015807 Walker A/P-loop; other site 698936015808 ATP binding site [chemical binding]; other site 698936015809 Q-loop/lid; other site 698936015810 ABC transporter signature motif; other site 698936015811 Walker B; other site 698936015812 D-loop; other site 698936015813 H-loop/switch region; other site 698936015814 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936015815 Walker A/P-loop; other site 698936015816 ATP binding site [chemical binding]; other site 698936015817 Q-loop/lid; other site 698936015818 ABC transporter signature motif; other site 698936015819 Walker B; other site 698936015820 D-loop; other site 698936015821 H-loop/switch region; other site 698936015822 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936015823 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936015824 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936015825 putative DNA binding site [nucleotide binding]; other site 698936015826 putative Zn2+ binding site [ion binding]; other site 698936015827 AsnC family; Region: AsnC_trans_reg; pfam01037 698936015828 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936015829 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698936015830 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 698936015831 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 698936015832 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 698936015833 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 698936015834 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698936015835 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698936015836 Family description; Region: DsbD_2; pfam13386 698936015837 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 698936015838 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 698936015839 Cytochrome c; Region: Cytochrom_C; pfam00034 698936015840 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698936015841 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 698936015842 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 698936015843 Low-spin heme binding site [chemical binding]; other site 698936015844 D-pathway; other site 698936015845 Putative water exit pathway; other site 698936015846 Binuclear center (active site) [active] 698936015847 K-pathway; other site 698936015848 Putative proton exit pathway; other site 698936015849 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698936015850 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698936015851 ring oligomerisation interface [polypeptide binding]; other site 698936015852 ATP/Mg binding site [chemical binding]; other site 698936015853 stacking interactions; other site 698936015854 hinge regions; other site 698936015855 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698936015856 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 698936015857 substrate-cofactor binding pocket; other site 698936015858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936015859 catalytic residue [active] 698936015860 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 698936015861 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 698936015862 Cu(I) binding site [ion binding]; other site 698936015863 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 698936015864 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698936015865 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698936015866 active site 698936015867 metal binding site [ion binding]; metal-binding site 698936015868 Cytochrome c [Energy production and conversion]; Region: COG3258 698936015869 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 698936015870 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698936015871 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 698936015872 Cytochrome c; Region: Cytochrom_C; cl11414 698936015873 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 698936015874 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 698936015875 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 698936015876 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698936015877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936015878 DNA-binding site [nucleotide binding]; DNA binding site 698936015879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936015880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936015881 homodimer interface [polypeptide binding]; other site 698936015882 catalytic residue [active] 698936015883 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 698936015884 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698936015885 Uncharacterized conserved protein [Function unknown]; Region: COG2128 698936015886 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936015887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936015888 NAD(P) binding site [chemical binding]; other site 698936015889 active site 698936015890 putative transcriptional regulator; Provisional; Region: PRK11640 698936015891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936015892 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 698936015893 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698936015894 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936015895 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936015896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936015897 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698936015898 dimerization interface [polypeptide binding]; other site 698936015899 methionine sulfoxide reductase B; Provisional; Region: PRK00222 698936015900 SelR domain; Region: SelR; pfam01641 698936015901 methionine sulfoxide reductase A; Provisional; Region: PRK14054 698936015902 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 698936015903 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 698936015904 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 698936015905 active site 698936015906 catalytic residues [active] 698936015907 Transglycosylase; Region: Transgly; pfam00912 698936015908 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 698936015909 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698936015910 BA14K-like protein; Region: BA14K; pfam07886 698936015911 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 698936015912 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 698936015913 Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004 698936015914 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 698936015915 transmembrane helices; other site 698936015916 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698936015917 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 698936015918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936015919 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936015920 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698936015921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936015922 putative DNA binding site [nucleotide binding]; other site 698936015923 putative Zn2+ binding site [ion binding]; other site 698936015924 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698936015925 hypothetical protein; Provisional; Region: PRK06184 698936015926 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698936015927 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698936015928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936015929 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936015930 putative substrate translocation pore; other site 698936015931 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698936015932 hydrophobic ligand binding site; other site 698936015933 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 698936015934 putative hydrophobic ligand binding site [chemical binding]; other site 698936015935 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936015936 dimerization interface [polypeptide binding]; other site 698936015937 putative DNA binding site [nucleotide binding]; other site 698936015938 putative Zn2+ binding site [ion binding]; other site 698936015939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 698936015940 Predicted nucleotide kinase (related to CMP and AMP kinases) [Nucleotide transport and metabolism]; Region: COG1936 698936015941 AAA domain; Region: AAA_17; pfam13207 698936015942 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936015943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936015944 LysR substrate binding domain; Region: LysR_substrate; pfam03466 698936015945 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 698936015946 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698936015947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936015948 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936015949 putative substrate translocation pore; other site 698936015950 hypothetical protein; Provisional; Region: PRK06834 698936015951 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698936015952 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936015953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936015954 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936015955 dimerization interface [polypeptide binding]; other site 698936015956 EamA-like transporter family; Region: EamA; pfam00892 698936015957 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698936015958 EamA-like transporter family; Region: EamA; pfam00892 698936015959 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698936015960 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698936015961 ligand binding site [chemical binding]; other site 698936015962 flexible hinge region; other site 698936015963 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 698936015964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936015965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936015966 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 698936015967 substrate binding pocket [chemical binding]; other site 698936015968 dimerization interface [polypeptide binding]; other site 698936015969 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698936015970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936015971 NAD(P) binding site [chemical binding]; other site 698936015972 active site 698936015973 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936015974 Predicted transcriptional regulators [Transcription]; Region: COG1733 698936015975 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 698936015976 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 698936015977 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 698936015978 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 698936015979 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936015980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936015981 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698936015982 putative effector binding pocket; other site 698936015983 dimerization interface [polypeptide binding]; other site 698936015984 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 698936015985 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 698936015986 potential catalytic triad [active] 698936015987 conserved cys residue [active] 698936015988 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 698936015989 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 698936015990 potential catalytic triad [active] 698936015991 conserved cys residue [active] 698936015992 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 698936015993 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936015994 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936015995 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698936015996 hypothetical protein; Provisional; Region: PRK06486 698936015997 intersubunit interface [polypeptide binding]; other site 698936015998 active site 698936015999 Zn2+ binding site [ion binding]; other site 698936016000 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 698936016001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936016002 motif II; other site 698936016003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936016004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936016005 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936016006 dimerization interface [polypeptide binding]; other site 698936016007 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936016008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936016009 NAD(P) binding site [chemical binding]; other site 698936016010 active site 698936016011 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936016012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936016013 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698936016014 putative effector binding pocket; other site 698936016015 dimerization interface [polypeptide binding]; other site 698936016016 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 698936016017 HicB family; Region: HicB; pfam05534 698936016018 Uncharacterized conserved protein [Function unknown]; Region: COG3246 698936016019 Helix-turn-helix domain; Region: HTH_17; cl17695 698936016020 PIN domain; Region: PIN_3; pfam13470 698936016021 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 698936016022 active site 698936016023 catalytic triad [active] 698936016024 oxyanion hole [active] 698936016025 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936016026 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936016027 TM-ABC transporter signature motif; other site 698936016028 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936016029 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936016030 TM-ABC transporter signature motif; other site 698936016031 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936016032 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936016033 Walker A/P-loop; other site 698936016034 ATP binding site [chemical binding]; other site 698936016035 Q-loop/lid; other site 698936016036 ABC transporter signature motif; other site 698936016037 Walker B; other site 698936016038 D-loop; other site 698936016039 H-loop/switch region; other site 698936016040 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936016041 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936016042 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 698936016043 putative ligand binding site [chemical binding]; other site 698936016044 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 698936016045 active site 698936016046 catalytic triad [active] 698936016047 oxyanion hole [active] 698936016048 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698936016049 putative switch regulator; other site 698936016050 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698936016051 non-specific DNA interactions [nucleotide binding]; other site 698936016052 DNA binding site [nucleotide binding] 698936016053 sequence specific DNA binding site [nucleotide binding]; other site 698936016054 putative cAMP binding site [chemical binding]; other site 698936016055 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698936016056 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698936016057 nucleotide binding site [chemical binding]; other site 698936016058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936016059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936016060 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 698936016061 putative dimer interface [polypeptide binding]; other site 698936016062 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936016063 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 698936016064 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 698936016065 putative active site [active] 698936016066 catalytic site [active] 698936016067 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 698936016068 putative active site [active] 698936016069 catalytic site [active] 698936016070 SnoaL-like domain; Region: SnoaL_2; pfam12680 698936016071 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698936016072 MarR family; Region: MarR; pfam01047 698936016073 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698936016074 Serine hydrolase; Region: Ser_hydrolase; cl17834 698936016075 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 698936016076 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698936016077 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936016078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936016079 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698936016080 putative effector binding pocket; other site 698936016081 dimerization interface [polypeptide binding]; other site 698936016082 Isochorismatase family; Region: Isochorismatase; pfam00857 698936016083 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 698936016084 catalytic triad [active] 698936016085 dimer interface [polypeptide binding]; other site 698936016086 conserved cis-peptide bond; other site 698936016087 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 698936016088 murein hydrolase B; Provisional; Region: PRK10760; cl17906 698936016089 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698936016090 DNA-binding site [nucleotide binding]; DNA binding site 698936016091 RNA-binding motif; other site 698936016092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936016093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936016094 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698936016095 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698936016096 Predicted transcriptional regulator [Transcription]; Region: COG1959 698936016097 Transcriptional regulator; Region: Rrf2; pfam02082 698936016098 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698936016099 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 698936016100 FAD binding pocket [chemical binding]; other site 698936016101 FAD binding motif [chemical binding]; other site 698936016102 phosphate binding motif [ion binding]; other site 698936016103 beta-alpha-beta structure motif; other site 698936016104 NAD binding pocket [chemical binding]; other site 698936016105 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936016106 catalytic loop [active] 698936016107 iron binding site [ion binding]; other site 698936016108 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 698936016109 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 698936016110 [2Fe-2S] cluster binding site [ion binding]; other site 698936016111 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 698936016112 putative alpha subunit interface [polypeptide binding]; other site 698936016113 putative active site [active] 698936016114 putative substrate binding site [chemical binding]; other site 698936016115 Fe binding site [ion binding]; other site 698936016116 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 698936016117 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936016118 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936016119 dimerization interface [polypeptide binding]; other site 698936016120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698936016121 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698936016122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936016123 S-adenosylmethionine binding site [chemical binding]; other site 698936016124 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698936016125 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 698936016126 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 698936016127 nudix motif; other site 698936016128 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698936016129 DNA-binding site [nucleotide binding]; DNA binding site 698936016130 RNA-binding motif; other site 698936016131 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 698936016132 Predicted chitinase [General function prediction only]; Region: COG3179 698936016133 catalytic residue [active] 698936016134 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698936016135 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698936016136 catalytic residues [active] 698936016137 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 698936016138 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 698936016139 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 698936016140 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 698936016141 thiS-thiF/thiG interaction site; other site 698936016142 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698936016143 Transposase; Region: HTH_Tnp_1; pfam01527 698936016144 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698936016145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698936016146 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698936016147 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 698936016148 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936016149 putative DNA binding site [nucleotide binding]; other site 698936016150 putative Zn2+ binding site [ion binding]; other site 698936016151 AsnC family; Region: AsnC_trans_reg; pfam01037 698936016152 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 698936016153 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 698936016154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936016155 catalytic residue [active] 698936016156 PAS fold; Region: PAS_7; pfam12860 698936016157 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936016158 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936016159 metal binding site [ion binding]; metal-binding site 698936016160 active site 698936016161 I-site; other site 698936016162 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698936016163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698936016164 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 698936016165 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698936016166 Transposase; Region: HTH_Tnp_1; pfam01527 698936016167 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698936016168 LabA_like proteins; Region: LabA; cd10911 698936016169 putative metal binding site [ion binding]; other site 698936016170 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698936016171 active site 698936016172 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936016173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936016174 DNA binding residues [nucleotide binding] 698936016175 dimerization interface [polypeptide binding]; other site 698936016176 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698936016177 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 698936016178 oligomer interface [polypeptide binding]; other site 698936016179 metal binding site [ion binding]; metal-binding site 698936016180 metal binding site [ion binding]; metal-binding site 698936016181 putative Cl binding site [ion binding]; other site 698936016182 basic sphincter; other site 698936016183 hydrophobic gate; other site 698936016184 periplasmic entrance; other site 698936016185 DDE domain; Region: DDE_Tnp_IS240; pfam13610 698936016186 Integrase core domain; Region: rve; pfam00665 698936016187 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 698936016188 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 698936016189 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698936016190 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 698936016191 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 698936016192 Cytochrome P450; Region: p450; cl12078 698936016193 potential frameshift: common BLAST hit: gi|334317044|ref|YP_004549663.1| N-acetyltransferase GCN5 698936016194 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698936016195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936016196 Coenzyme A binding pocket [chemical binding]; other site 698936016197 acyl carrier protein; Provisional; Region: acpP; PRK00982 698936016198 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698936016199 oligomerisation interface [polypeptide binding]; other site 698936016200 mobile loop; other site 698936016201 roof hairpin; other site 698936016202 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698936016203 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698936016204 ring oligomerisation interface [polypeptide binding]; other site 698936016205 ATP/Mg binding site [chemical binding]; other site 698936016206 stacking interactions; other site 698936016207 hinge regions; other site 698936016208 Predicted periplasmic protein [Function unknown]; Region: COG3904 698936016209 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 698936016210 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 698936016211 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 698936016212 catalytic residues [active] 698936016213 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698936016214 Helix-turn-helix domain; Region: HTH_38; pfam13936 698936016215 Homeodomain-like domain; Region: HTH_32; pfam13565 698936016216 Integrase core domain; Region: rve; pfam00665 698936016217 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698936016218 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 698936016219 putative active site [active] 698936016220 putative metal binding site [ion binding]; other site 698936016221 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698936016222 AAA domain; Region: AAA_17; pfam13207 698936016223 AAA domain; Region: AAA_18; pfam13238 698936016224 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698936016225 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698936016226 HD domain; Region: HD_3; cl17350 698936016227 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698936016228 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698936016229 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 698936016230 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 698936016231 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 698936016232 Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462 698936016233 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 698936016234 ThiF family; Region: ThiF; pfam00899 698936016235 ATP binding site [chemical binding]; other site 698936016236 substrate interface [chemical binding]; other site 698936016237 Plant protein of unknown function (DUF827); Region: DUF827; pfam05701 698936016238 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 698936016239 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 698936016240 putative active site [active] 698936016241 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698936016242 active site 698936016243 DNA binding site [nucleotide binding] 698936016244 Int/Topo IB signature motif; other site 698936016245 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 698936016246 putative dimer interface [polypeptide binding]; other site 698936016247 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936016248 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 698936016249 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 698936016250 Uncharacterized conserved protein [Function unknown]; Region: COG5654 698936016251 Uncharacterized conserved protein [Function unknown]; Region: COG5642 698936016252 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 698936016253 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698936016254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936016255 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 698936016256 dimerization interface [polypeptide binding]; other site 698936016257 substrate binding pocket [chemical binding]; other site 698936016258 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698936016259 homotrimer interaction site [polypeptide binding]; other site 698936016260 putative active site [active] 698936016261 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698936016262 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 698936016263 active site 698936016264 FMN binding site [chemical binding]; other site 698936016265 substrate binding site [chemical binding]; other site 698936016266 putative catalytic residue [active] 698936016267 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698936016268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936016269 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936016270 dimerization interface [polypeptide binding]; other site 698936016271 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 698936016272 Transglycosylase; Region: Transgly; pfam00912 698936016273 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698936016274 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698936016275 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698936016276 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698936016277 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 698936016278 Bacterial SH3 domain; Region: SH3_3; pfam08239 698936016279 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936016280 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936016281 metal binding site [ion binding]; metal-binding site 698936016282 active site 698936016283 I-site; other site 698936016284 non-specific DNA interactions [nucleotide binding]; other site 698936016285 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 698936016286 DNA binding site [nucleotide binding] 698936016287 sequence specific DNA binding site [nucleotide binding]; other site 698936016288 putative cAMP binding site [chemical binding]; other site 698936016289 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698936016290 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698936016291 nucleotide binding site [chemical binding]; other site 698936016292 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698936016293 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936016294 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936016295 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 698936016296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936016297 dimer interface [polypeptide binding]; other site 698936016298 conserved gate region; other site 698936016299 putative PBP binding loops; other site 698936016300 ABC-ATPase subunit interface; other site 698936016301 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936016302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936016303 dimer interface [polypeptide binding]; other site 698936016304 conserved gate region; other site 698936016305 putative PBP binding loops; other site 698936016306 ABC-ATPase subunit interface; other site 698936016307 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698936016308 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936016309 Walker A/P-loop; other site 698936016310 ATP binding site [chemical binding]; other site 698936016311 Q-loop/lid; other site 698936016312 ABC transporter signature motif; other site 698936016313 Walker B; other site 698936016314 D-loop; other site 698936016315 H-loop/switch region; other site 698936016316 TOBE domain; Region: TOBE_2; pfam08402 698936016317 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936016318 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936016319 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936016320 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936016321 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936016322 active site 698936016323 catalytic tetrad [active] 698936016324 aminoglycoside resistance protein; Provisional; Region: PRK13746 698936016325 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 698936016326 active site 698936016327 NTP binding site [chemical binding]; other site 698936016328 metal binding triad [ion binding]; metal-binding site 698936016329 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 698936016330 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 698936016331 putative C-terminal domain interface [polypeptide binding]; other site 698936016332 putative GSH binding site (G-site) [chemical binding]; other site 698936016333 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936016334 putative dimer interface [polypeptide binding]; other site 698936016335 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 698936016336 dimer interface [polypeptide binding]; other site 698936016337 N-terminal domain interface [polypeptide binding]; other site 698936016338 putative substrate binding pocket (H-site) [chemical binding]; other site 698936016339 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698936016340 Part of AAA domain; Region: AAA_19; pfam13245 698936016341 Family description; Region: UvrD_C_2; pfam13538 698936016342 Ion channel; Region: Ion_trans_2; pfam07885 698936016343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698936016344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936016345 active site 698936016346 phosphorylation site [posttranslational modification] 698936016347 intermolecular recognition site; other site 698936016348 dimerization interface [polypeptide binding]; other site 698936016349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936016350 DNA binding site [nucleotide binding] 698936016351 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 698936016352 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 698936016353 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 698936016354 Ligand Binding Site [chemical binding]; other site 698936016355 GAF domain; Region: GAF_3; pfam13492 698936016356 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936016357 dimer interface [polypeptide binding]; other site 698936016358 phosphorylation site [posttranslational modification] 698936016359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936016360 ATP binding site [chemical binding]; other site 698936016361 Mg2+ binding site [ion binding]; other site 698936016362 G-X-G motif; other site 698936016363 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 698936016364 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 698936016365 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698936016366 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698936016367 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 698936016368 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 698936016369 muropeptide transporter; Validated; Region: ampG; cl17669 698936016370 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 698936016371 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698936016372 inhibitor-cofactor binding pocket; inhibition site 698936016373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936016374 catalytic residue [active] 698936016375 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 698936016376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936016377 catalytic residue [active] 698936016378 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 698936016379 IucA / IucC family; Region: IucA_IucC; pfam04183 698936016380 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698936016381 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 698936016382 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 698936016383 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 698936016384 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698936016385 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 698936016386 IucA / IucC family; Region: IucA_IucC; pfam04183 698936016387 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698936016388 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936016389 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936016390 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 698936016391 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 698936016392 N-terminal plug; other site 698936016393 ligand-binding site [chemical binding]; other site 698936016394 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 698936016395 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 698936016396 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936016397 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936016398 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698936016399 putative effector binding pocket; other site 698936016400 putative dimerization interface [polypeptide binding]; other site 698936016401 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698936016402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936016403 NAD(P) binding site [chemical binding]; other site 698936016404 active site 698936016405 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 698936016406 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 698936016407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936016408 S-adenosylmethionine binding site [chemical binding]; other site 698936016409 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 698936016410 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936016411 catalytic loop [active] 698936016412 iron binding site [ion binding]; other site 698936016413 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698936016414 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 698936016415 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 698936016416 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698936016417 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698936016418 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936016419 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698936016420 active site 698936016421 DNA polymerase IV; Validated; Region: PRK02406 698936016422 DNA binding site [nucleotide binding] 698936016423 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936016424 cyclase homology domain; Region: CHD; cd07302 698936016425 nucleotidyl binding site; other site 698936016426 metal binding site [ion binding]; metal-binding site 698936016427 dimer interface [polypeptide binding]; other site 698936016428 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698936016429 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 698936016430 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 698936016431 putative ligand binding site [chemical binding]; other site 698936016432 Amidase; Region: Amidase; cl11426 698936016433 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698936016434 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 698936016435 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936016436 Walker A/P-loop; other site 698936016437 ATP binding site [chemical binding]; other site 698936016438 Q-loop/lid; other site 698936016439 ABC transporter signature motif; other site 698936016440 Walker B; other site 698936016441 D-loop; other site 698936016442 H-loop/switch region; other site 698936016443 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936016444 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936016445 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698936016446 TM-ABC transporter signature motif; other site 698936016447 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936016448 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698936016449 TM-ABC transporter signature motif; other site 698936016450 cytosine deaminase; Validated; Region: PRK07572 698936016451 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 698936016452 active site 698936016453 Transcriptional activator [Transcription]; Region: ChrR; COG3806 698936016454 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 698936016455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936016456 putative substrate translocation pore; other site 698936016457 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 698936016458 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 698936016459 dimer interface [polypeptide binding]; other site 698936016460 active site 698936016461 heme binding site [chemical binding]; other site 698936016462 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 698936016463 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936016464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936016465 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698936016466 putative effector binding pocket; other site 698936016467 putative dimerization interface [polypeptide binding]; other site 698936016468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936016469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936016470 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698936016471 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 698936016472 NADP binding site [chemical binding]; other site 698936016473 dimer interface [polypeptide binding]; other site 698936016474 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698936016475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936016476 Walker A/P-loop; other site 698936016477 ATP binding site [chemical binding]; other site 698936016478 Q-loop/lid; other site 698936016479 ABC transporter signature motif; other site 698936016480 Walker B; other site 698936016481 D-loop; other site 698936016482 H-loop/switch region; other site 698936016483 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698936016484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936016485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936016486 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 698936016487 replication initiation protein RepC; Provisional; Region: PRK13824 698936016488 Replication protein C N-terminal domain; Region: RP-C; pfam03428 698936016489 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 698936016490 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 698936016491 ParB-like nuclease domain; Region: ParB; smart00470 698936016492 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 698936016493 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698936016494 P-loop; other site 698936016495 Magnesium ion binding site [ion binding]; other site 698936016496 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698936016497 Magnesium ion binding site [ion binding]; other site 698936016498 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 698936016499 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 698936016500 [4Fe-4S] binding site [ion binding]; other site 698936016501 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698936016502 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 698936016503 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 698936016504 molybdopterin cofactor binding site; other site 698936016505 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 698936016506 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 698936016507 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 698936016508 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 698936016509 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 698936016510 Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058 698936016511 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 698936016512 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 698936016513 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 698936016514 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 698936016515 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698936016516 catalytic residue [active] 698936016517 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 698936016518 Sel1-like repeats; Region: SEL1; smart00671 698936016519 Sel1-like repeats; Region: SEL1; smart00671 698936016520 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 698936016521 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 698936016522 G1 box; other site 698936016523 putative GEF interaction site [polypeptide binding]; other site 698936016524 GTP/Mg2+ binding site [chemical binding]; other site 698936016525 Switch I region; other site 698936016526 G2 box; other site 698936016527 G3 box; other site 698936016528 Switch II region; other site 698936016529 G4 box; other site 698936016530 G5 box; other site 698936016531 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 698936016532 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 698936016533 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 698936016534 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 698936016535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 698936016536 active site 698936016537 phosphorylation site [posttranslational modification] 698936016538 intermolecular recognition site; other site 698936016539 dimerization interface [polypeptide binding]; other site 698936016540 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 698936016541 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 698936016542 selenophosphate synthetase; Provisional; Region: PRK00943 698936016543 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 698936016544 dimerization interface [polypeptide binding]; other site 698936016545 putative ATP binding site [chemical binding]; other site 698936016546 NADH dehydrogenase subunit C; Validated; Region: PRK07735 698936016547 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 698936016548 active site 698936016549 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 698936016550 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698936016551 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698936016552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936016553 Walker A/P-loop; other site 698936016554 ATP binding site [chemical binding]; other site 698936016555 Q-loop/lid; other site 698936016556 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698936016557 ABC transporter signature motif; other site 698936016558 Walker B; other site 698936016559 D-loop; other site 698936016560 ABC transporter; Region: ABC_tran_2; pfam12848 698936016561 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698936016562 transcriptional regulator; Provisional; Region: PRK10632 698936016563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936016564 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 698936016565 putative effector binding pocket; other site 698936016566 putative dimerization interface [polypeptide binding]; other site 698936016567 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 698936016568 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698936016569 putative NAD(P) binding site [chemical binding]; other site 698936016570 Uncharacterized conserved protein [Function unknown]; Region: COG5552 698936016571 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936016572 DNA binding site [nucleotide binding] 698936016573 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 698936016574 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698936016575 putative ligand binding site [chemical binding]; other site 698936016576 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936016577 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936016578 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936016579 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 698936016580 DNA interaction; other site 698936016581 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 698936016582 active site 698936016583 catalytic residues [active] 698936016584 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 698936016585 classical (c) SDRs; Region: SDR_c; cd05233 698936016586 NAD(P) binding site [chemical binding]; other site 698936016587 active site 698936016588 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 698936016589 CoA-transferase family III; Region: CoA_transf_3; pfam02515 698936016590 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698936016591 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698936016592 substrate binding site [chemical binding]; other site 698936016593 oxyanion hole (OAH) forming residues; other site 698936016594 trimer interface [polypeptide binding]; other site 698936016595 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698936016596 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936016597 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936016598 TM-ABC transporter signature motif; other site 698936016599 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936016600 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 698936016601 ligand binding site [chemical binding]; other site 698936016602 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936016603 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936016604 Walker A/P-loop; other site 698936016605 ATP binding site [chemical binding]; other site 698936016606 Q-loop/lid; other site 698936016607 ABC transporter signature motif; other site 698936016608 Walker B; other site 698936016609 D-loop; other site 698936016610 H-loop/switch region; other site 698936016611 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936016612 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 698936016613 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 698936016614 metal binding site [ion binding]; metal-binding site 698936016615 substrate binding pocket [chemical binding]; other site 698936016616 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 698936016617 dimerization interface [polypeptide binding]; other site 698936016618 putative active cleft [active] 698936016619 aldose dehydrogenase; Validated; Region: PRK06398 698936016620 classical (c) SDRs; Region: SDR_c; cd05233 698936016621 NAD(P) binding site [chemical binding]; other site 698936016622 active site 698936016623 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 698936016624 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936016625 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936016626 DNA-binding site [nucleotide binding]; DNA binding site 698936016627 FCD domain; Region: FCD; pfam07729 698936016628 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936016629 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936016630 DNA-binding site [nucleotide binding]; DNA binding site 698936016631 FCD domain; Region: FCD; pfam07729 698936016632 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 698936016633 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 698936016634 active site pocket [active] 698936016635 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936016636 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936016637 DNA-binding site [nucleotide binding]; DNA binding site 698936016638 FCD domain; Region: FCD; pfam07729 698936016639 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936016640 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 698936016641 putative ligand binding site [chemical binding]; other site 698936016642 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936016643 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936016644 TM-ABC transporter signature motif; other site 698936016645 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698936016646 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936016647 Walker A/P-loop; other site 698936016648 ATP binding site [chemical binding]; other site 698936016649 Q-loop/lid; other site 698936016650 ABC transporter signature motif; other site 698936016651 Walker B; other site 698936016652 D-loop; other site 698936016653 H-loop/switch region; other site 698936016654 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 698936016655 classical (c) SDRs; Region: SDR_c; cd05233 698936016656 NAD(P) binding site [chemical binding]; other site 698936016657 active site 698936016658 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 698936016659 active site 698936016660 catalytic residues [active] 698936016661 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698936016662 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698936016663 DNA binding site [nucleotide binding] 698936016664 domain linker motif; other site 698936016665 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 698936016666 putative dimerization interface [polypeptide binding]; other site 698936016667 putative ligand binding site [chemical binding]; other site 698936016668 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936016669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936016670 dimer interface [polypeptide binding]; other site 698936016671 conserved gate region; other site 698936016672 putative PBP binding loops; other site 698936016673 ABC-ATPase subunit interface; other site 698936016674 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936016675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936016676 dimer interface [polypeptide binding]; other site 698936016677 conserved gate region; other site 698936016678 putative PBP binding loops; other site 698936016679 ABC-ATPase subunit interface; other site 698936016680 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698936016681 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936016682 substrate binding pocket [chemical binding]; other site 698936016683 membrane-bound complex binding site; other site 698936016684 hinge residues; other site 698936016685 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698936016686 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698936016687 Walker A/P-loop; other site 698936016688 ATP binding site [chemical binding]; other site 698936016689 Q-loop/lid; other site 698936016690 ABC transporter signature motif; other site 698936016691 Walker B; other site 698936016692 D-loop; other site 698936016693 H-loop/switch region; other site 698936016694 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 698936016695 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 698936016696 putative ligand binding site [chemical binding]; other site 698936016697 NAD binding site [chemical binding]; other site 698936016698 catalytic site [active] 698936016699 EthD domain; Region: EthD; cl17553 698936016700 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 698936016701 homotrimer interaction site [polypeptide binding]; other site 698936016702 putative active site [active] 698936016703 BA14K-like protein; Region: BA14K; pfam07886 698936016704 BA14K-like protein; Region: BA14K; pfam07886 698936016705 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698936016706 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698936016707 homodimer interface [polypeptide binding]; other site 698936016708 substrate-cofactor binding pocket; other site 698936016709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936016710 catalytic residue [active] 698936016711 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 698936016712 homodimer interface [polypeptide binding]; other site 698936016713 homotetramer interface [polypeptide binding]; other site 698936016714 active site pocket [active] 698936016715 cleavage site 698936016716 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936016717 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936016718 LysR substrate binding domain; Region: LysR_substrate; pfam03466 698936016719 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 698936016720 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 698936016721 active site 698936016722 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698936016723 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936016724 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936016725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936016726 dimer interface [polypeptide binding]; other site 698936016727 conserved gate region; other site 698936016728 putative PBP binding loops; other site 698936016729 ABC-ATPase subunit interface; other site 698936016730 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698936016731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936016732 dimer interface [polypeptide binding]; other site 698936016733 conserved gate region; other site 698936016734 putative PBP binding loops; other site 698936016735 ABC-ATPase subunit interface; other site 698936016736 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698936016737 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936016738 Walker A/P-loop; other site 698936016739 ATP binding site [chemical binding]; other site 698936016740 Q-loop/lid; other site 698936016741 ABC transporter signature motif; other site 698936016742 Walker B; other site 698936016743 D-loop; other site 698936016744 H-loop/switch region; other site 698936016745 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936016746 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698936016747 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936016748 Walker A/P-loop; other site 698936016749 ATP binding site [chemical binding]; other site 698936016750 Q-loop/lid; other site 698936016751 ABC transporter signature motif; other site 698936016752 Walker B; other site 698936016753 D-loop; other site 698936016754 H-loop/switch region; other site 698936016755 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936016756 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698936016757 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936016758 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 698936016759 putative active site [active] 698936016760 heme pocket [chemical binding]; other site 698936016761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936016762 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 698936016763 putative active site [active] 698936016764 heme pocket [chemical binding]; other site 698936016765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936016766 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 698936016767 putative active site [active] 698936016768 heme pocket [chemical binding]; other site 698936016769 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936016770 putative active site [active] 698936016771 heme pocket [chemical binding]; other site 698936016772 PAS domain S-box; Region: sensory_box; TIGR00229 698936016773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936016774 putative active site [active] 698936016775 heme pocket [chemical binding]; other site 698936016776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698936016777 HWE histidine kinase; Region: HWE_HK; pfam07536 698936016778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936016779 active site 698936016780 phosphorylation site [posttranslational modification] 698936016781 intermolecular recognition site; other site 698936016782 dimerization interface [polypeptide binding]; other site 698936016783 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 698936016784 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698936016785 HSP70 interaction site [polypeptide binding]; other site 698936016786 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698936016787 substrate binding site [polypeptide binding]; other site 698936016788 dimer interface [polypeptide binding]; other site 698936016789 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 698936016790 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698936016791 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 698936016792 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698936016793 ring oligomerisation interface [polypeptide binding]; other site 698936016794 ATP/Mg binding site [chemical binding]; other site 698936016795 stacking interactions; other site 698936016796 hinge regions; other site 698936016797 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698936016798 oligomerisation interface [polypeptide binding]; other site 698936016799 mobile loop; other site 698936016800 roof hairpin; other site 698936016801 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698936016802 DNA-binding site [nucleotide binding]; DNA binding site 698936016803 RNA-binding motif; other site 698936016804 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 698936016805 Fatty acid desaturase; Region: FA_desaturase; pfam00487 698936016806 putative di-iron ligands [ion binding]; other site 698936016807 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698936016808 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698936016809 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 698936016810 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936016811 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936016812 metal binding site [ion binding]; metal-binding site 698936016813 active site 698936016814 I-site; other site 698936016815 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698936016816 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 698936016817 active site 698936016818 catalytic triad [active] 698936016819 RNA polymerase sigma factor; Provisional; Region: PRK12547 698936016820 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698936016821 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698936016822 DNA binding residues [nucleotide binding] 698936016823 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 698936016824 transcription elongation factor regulatory protein; Validated; Region: PRK06342 698936016825 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698936016826 malonyl-CoA synthase; Validated; Region: PRK07514 698936016827 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 698936016828 acyl-activating enzyme (AAE) consensus motif; other site 698936016829 active site 698936016830 AMP binding site [chemical binding]; other site 698936016831 CoA binding site [chemical binding]; other site 698936016832 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 698936016833 DctM-like transporters; Region: DctM; pfam06808 698936016834 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 698936016835 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 698936016836 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 698936016837 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 698936016838 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936016839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936016840 DNA-binding site [nucleotide binding]; DNA binding site 698936016841 FCD domain; Region: FCD; pfam07729 698936016842 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 698936016843 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 698936016844 BON domain; Region: BON; pfam04972 698936016845 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 698936016846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936016847 binding surface 698936016848 Tetratricopeptide repeat; Region: TPR_16; pfam13432 698936016849 TPR motif; other site 698936016850 hypothetical protein; Provisional; Region: PRK08317 698936016851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936016852 S-adenosylmethionine binding site [chemical binding]; other site 698936016853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936016854 S-adenosylmethionine binding site [chemical binding]; other site 698936016855 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 698936016856 Uncharacterized conserved protein [Function unknown]; Region: COG2326 698936016857 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698936016858 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698936016859 GYD domain; Region: GYD; pfam08734 698936016860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936016861 binding surface 698936016862 TPR motif; other site 698936016863 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698936016864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936016865 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 698936016866 dimerization interface [polypeptide binding]; other site 698936016867 substrate binding pocket [chemical binding]; other site 698936016868 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698936016869 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698936016870 DNA-binding site [nucleotide binding]; DNA binding site 698936016871 RNA-binding motif; other site 698936016872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936016873 putative substrate translocation pore; other site 698936016874 short chain dehydrogenase; Provisional; Region: PRK06701 698936016875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936016876 NAD(P) binding site [chemical binding]; other site 698936016877 active site 698936016878 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936016879 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936016880 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 698936016881 putative hydrophobic ligand binding site [chemical binding]; other site 698936016882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698936016883 dimerization interface [polypeptide binding]; other site 698936016884 putative DNA binding site [nucleotide binding]; other site 698936016885 putative Zn2+ binding site [ion binding]; other site 698936016886 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 698936016887 Strictosidine synthase; Region: Str_synth; pfam03088 698936016888 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936016889 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936016890 TM-ABC transporter signature motif; other site 698936016891 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936016892 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936016893 TM-ABC transporter signature motif; other site 698936016894 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936016895 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936016896 Walker A/P-loop; other site 698936016897 ATP binding site [chemical binding]; other site 698936016898 Q-loop/lid; other site 698936016899 ABC transporter signature motif; other site 698936016900 Walker B; other site 698936016901 D-loop; other site 698936016902 H-loop/switch region; other site 698936016903 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936016904 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936016905 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 698936016906 putative ligand binding site [chemical binding]; other site 698936016907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698936016908 Histidine kinase; Region: HisKA_3; pfam07730 698936016909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936016910 ATP binding site [chemical binding]; other site 698936016911 Mg2+ binding site [ion binding]; other site 698936016912 G-X-G motif; other site 698936016913 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936016914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936016915 active site 698936016916 phosphorylation site [posttranslational modification] 698936016917 intermolecular recognition site; other site 698936016918 dimerization interface [polypeptide binding]; other site 698936016919 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 698936016920 DNA binding residues [nucleotide binding] 698936016921 5-keto 4-deoxyuronate isomerase [Carbohydrate transport and metabolism]; Region: KduI; COG3717 698936016922 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698936016923 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936016924 Walker A/P-loop; other site 698936016925 ATP binding site [chemical binding]; other site 698936016926 Q-loop/lid; other site 698936016927 ABC transporter signature motif; other site 698936016928 Walker B; other site 698936016929 D-loop; other site 698936016930 H-loop/switch region; other site 698936016931 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936016932 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936016933 TM-ABC transporter signature motif; other site 698936016934 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698936016935 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698936016936 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698936016937 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 698936016938 NAD(P) binding site [chemical binding]; other site 698936016939 catalytic residues [active] 698936016940 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936016941 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936016942 DNA-binding site [nucleotide binding]; DNA binding site 698936016943 FCD domain; Region: FCD; pfam07729 698936016944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936016945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936016946 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 698936016947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936016948 putative substrate translocation pore; other site 698936016949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936016950 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 698936016951 glutamate dehydrogenase; Provisional; Region: PRK09414 698936016952 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698936016953 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 698936016954 NAD(P) binding site [chemical binding]; other site 698936016955 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 698936016956 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698936016957 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 698936016958 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 698936016959 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 698936016960 active site 698936016961 homotetramer interface [polypeptide binding]; other site 698936016962 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 698936016963 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698936016964 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698936016965 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936016966 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 698936016967 putative NAD(P) binding site [chemical binding]; other site 698936016968 active site 698936016969 putative substrate binding site [chemical binding]; other site 698936016970 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698936016971 FAD binding domain; Region: FAD_binding_4; pfam01565 698936016972 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936016973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936016974 DNA-binding site [nucleotide binding]; DNA binding site 698936016975 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698936016976 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 698936016977 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698936016978 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 698936016979 DctM-like transporters; Region: DctM; pfam06808 698936016980 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 698936016981 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 698936016982 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 698936016983 Uncharacterized conserved protein [Function unknown]; Region: COG5482 698936016984 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 698936016985 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698936016986 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698936016987 active site 698936016988 catalytic site [active] 698936016989 substrate binding site [chemical binding]; other site 698936016990 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698936016991 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698936016992 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698936016993 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698936016994 tetramerization interface [polypeptide binding]; other site 698936016995 NAD(P) binding site [chemical binding]; other site 698936016996 catalytic residues [active] 698936016997 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 698936016998 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 698936016999 active site 698936017000 NAD binding site [chemical binding]; other site 698936017001 metal binding site [ion binding]; metal-binding site 698936017002 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 698936017003 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936017004 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936017005 DNA-binding site [nucleotide binding]; DNA binding site 698936017006 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698936017007 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936017008 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936017009 Walker A/P-loop; other site 698936017010 ATP binding site [chemical binding]; other site 698936017011 Q-loop/lid; other site 698936017012 ABC transporter signature motif; other site 698936017013 Walker B; other site 698936017014 D-loop; other site 698936017015 H-loop/switch region; other site 698936017016 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936017017 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936017018 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936017019 TM-ABC transporter signature motif; other site 698936017020 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936017021 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 698936017022 putative ligand binding site [chemical binding]; other site 698936017023 intracellular protease, PfpI family; Region: PfpI; TIGR01382 698936017024 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 698936017025 conserved cys residue [active] 698936017026 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 698936017027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936017028 S-adenosylmethionine binding site [chemical binding]; other site 698936017029 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 698936017030 Methylamine utilisation protein MauE; Region: MauE; pfam07291 698936017031 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 698936017032 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 698936017033 DNA binding residues [nucleotide binding] 698936017034 dimer interface [polypeptide binding]; other site 698936017035 mercury binding site [ion binding]; other site 698936017036 TIGR02588 family protein; Region: TIGR02588 698936017037 Transposase; Region: HTH_Tnp_IS630; pfam01710 698936017038 Homeodomain-like domain; Region: HTH_32; pfam13565 698936017039 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698936017040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698936017041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936017042 active site 698936017043 phosphorylation site [posttranslational modification] 698936017044 intermolecular recognition site; other site 698936017045 dimerization interface [polypeptide binding]; other site 698936017046 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 698936017047 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 698936017048 Protein of unknown function (DUF2390); Region: DUF2390; cl02376 698936017049 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 698936017050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936017051 DNA-binding site [nucleotide binding]; DNA binding site 698936017052 UTRA domain; Region: UTRA; pfam07702 698936017053 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 698936017054 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 698936017055 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 698936017056 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936017057 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936017058 hypothetical protein; Provisional; Region: PRK07475 698936017059 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 698936017060 Flavoprotein; Region: Flavoprotein; pfam02441 698936017061 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 698936017062 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 698936017063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936017064 DNA-binding site [nucleotide binding]; DNA binding site 698936017065 UTRA domain; Region: UTRA; pfam07702 698936017066 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698936017067 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 698936017068 NAD(P) binding site [chemical binding]; other site 698936017069 catalytic residues [active] 698936017070 thiamine pyrophosphate protein; Validated; Region: PRK08199 698936017071 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698936017072 PYR/PP interface [polypeptide binding]; other site 698936017073 dimer interface [polypeptide binding]; other site 698936017074 TPP binding site [chemical binding]; other site 698936017075 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698936017076 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 698936017077 TPP-binding site [chemical binding]; other site 698936017078 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 698936017079 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698936017080 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698936017081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936017082 Walker A/P-loop; other site 698936017083 ATP binding site [chemical binding]; other site 698936017084 Q-loop/lid; other site 698936017085 ABC transporter signature motif; other site 698936017086 Walker B; other site 698936017087 D-loop; other site 698936017088 H-loop/switch region; other site 698936017089 TOBE domain; Region: TOBE; pfam03459 698936017090 TOBE domain; Region: TOBE_2; pfam08402 698936017091 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 698936017092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936017093 dimer interface [polypeptide binding]; other site 698936017094 conserved gate region; other site 698936017095 putative PBP binding loops; other site 698936017096 ABC-ATPase subunit interface; other site 698936017097 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936017098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936017099 putative PBP binding loops; other site 698936017100 ABC-ATPase subunit interface; other site 698936017101 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 698936017102 homotrimer interaction site [polypeptide binding]; other site 698936017103 putative active site [active] 698936017104 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936017105 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698936017106 substrate binding pocket [chemical binding]; other site 698936017107 membrane-bound complex binding site; other site 698936017108 hinge residues; other site 698936017109 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936017110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936017111 dimer interface [polypeptide binding]; other site 698936017112 conserved gate region; other site 698936017113 putative PBP binding loops; other site 698936017114 ABC-ATPase subunit interface; other site 698936017115 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698936017116 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698936017117 Walker A/P-loop; other site 698936017118 ATP binding site [chemical binding]; other site 698936017119 Q-loop/lid; other site 698936017120 ABC transporter signature motif; other site 698936017121 Walker B; other site 698936017122 D-loop; other site 698936017123 H-loop/switch region; other site 698936017124 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936017125 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936017126 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698936017127 Uncharacterized conserved protein [Function unknown]; Region: COG5588 698936017128 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 698936017129 Protein of unknown function (DUF1515); Region: DUF1515; pfam07439 698936017130 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 698936017131 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 698936017132 active site 698936017133 DNA binding site [nucleotide binding] 698936017134 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 698936017135 DNA binding site [nucleotide binding] 698936017136 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 698936017137 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936017138 putative homodimer interface [polypeptide binding]; other site 698936017139 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698936017140 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698936017141 UDP-galactopyranose mutase; Region: GLF; pfam03275 698936017142 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 698936017143 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698936017144 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936017145 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936017146 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 698936017147 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 698936017148 putative NAD(P) binding site [chemical binding]; other site 698936017149 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698936017150 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698936017151 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698936017152 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 698936017153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936017154 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936017155 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936017156 potential frameshift: common BLAST hit: gi|337266582|ref|YP_004610637.1| YadA domain-containing protein 698936017157 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 698936017158 trimer interface [polypeptide binding]; other site 698936017159 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 698936017160 trimer interface [polypeptide binding]; other site 698936017161 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 698936017162 trimer interface [polypeptide binding]; other site 698936017163 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 698936017164 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 698936017165 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 698936017166 Haemagglutinin; Region: HIM; pfam05662 698936017167 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 698936017168 trimer interface [polypeptide binding]; other site 698936017169 YadA-like C-terminal region; Region: YadA; pfam03895 698936017170 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 698936017171 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 698936017172 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 698936017173 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 698936017174 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 698936017175 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 698936017176 LytTr DNA-binding domain; Region: LytTR; smart00850 698936017177 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 698936017178 Bacterial TniB protein; Region: TniB; pfam05621 698936017179 AAA domain; Region: AAA_22; pfam13401 698936017180 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 698936017181 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 698936017182 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 698936017183 NmrA-like family; Region: NmrA; pfam05368 698936017184 NADP binding site [chemical binding]; other site 698936017185 active site 698936017186 regulatory binding site [polypeptide binding]; other site 698936017187 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698936017188 MULE transposase domain; Region: MULE; pfam10551 698936017189 Fic family protein [Function unknown]; Region: COG3177 698936017190 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698936017191 Fic/DOC family; Region: Fic; pfam02661 698936017192 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 698936017193 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 698936017194 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 698936017195 Moco binding site; other site 698936017196 metal coordination site [ion binding]; other site 698936017197 dimerization interface [polypeptide binding]; other site 698936017198 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 698936017199 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 698936017200 active site 698936017201 non-prolyl cis peptide bond; other site 698936017202 Putative NADH-flavin reductase [General function prediction only]; Region: COG2910 698936017203 NADH(P)-binding; Region: NAD_binding_10; pfam13460 698936017204 NAD(P) binding site [chemical binding]; other site 698936017205 active site 698936017206 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 698936017207 hypothetical protein; Provisional; Region: PRK07236 698936017208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936017209 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698936017210 NAD(P) binding site [chemical binding]; other site 698936017211 active site 698936017212 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 698936017213 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698936017214 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 698936017215 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 698936017216 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 698936017217 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 698936017218 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936017219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936017220 dimer interface [polypeptide binding]; other site 698936017221 conserved gate region; other site 698936017222 putative PBP binding loops; other site 698936017223 ABC-ATPase subunit interface; other site 698936017224 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698936017225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936017226 dimer interface [polypeptide binding]; other site 698936017227 conserved gate region; other site 698936017228 putative PBP binding loops; other site 698936017229 ABC-ATPase subunit interface; other site 698936017230 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698936017231 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936017232 Walker A/P-loop; other site 698936017233 ATP binding site [chemical binding]; other site 698936017234 Q-loop/lid; other site 698936017235 ABC transporter signature motif; other site 698936017236 Walker B; other site 698936017237 D-loop; other site 698936017238 H-loop/switch region; other site 698936017239 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936017240 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 698936017241 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936017242 Walker A/P-loop; other site 698936017243 ATP binding site [chemical binding]; other site 698936017244 Q-loop/lid; other site 698936017245 ABC transporter signature motif; other site 698936017246 Walker B; other site 698936017247 D-loop; other site 698936017248 H-loop/switch region; other site 698936017249 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 698936017250 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936017251 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936017252 active site 698936017253 catalytic tetrad [active] 698936017254 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936017255 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 698936017256 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 698936017257 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698936017258 active site 698936017259 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 698936017260 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 698936017261 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 698936017262 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 698936017263 Walker A/P-loop; other site 698936017264 ATP binding site [chemical binding]; other site 698936017265 Q-loop/lid; other site 698936017266 ABC transporter signature motif; other site 698936017267 Walker B; other site 698936017268 D-loop; other site 698936017269 H-loop/switch region; other site 698936017270 TOBE-like domain; Region: TOBE_3; pfam12857 698936017271 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698936017272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936017273 active site 698936017274 phosphorylation site [posttranslational modification] 698936017275 intermolecular recognition site; other site 698936017276 dimerization interface [polypeptide binding]; other site 698936017277 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698936017278 HWE histidine kinase; Region: HWE_HK; pfam07536 698936017279 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 698936017280 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698936017281 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698936017282 Walker A motif; other site 698936017283 Walker A motif; other site 698936017284 ATP binding site [chemical binding]; other site 698936017285 Walker B motif; other site 698936017286 KaiC; Region: KaiC; pfam06745 698936017287 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 698936017288 Walker A motif; other site 698936017289 ATP binding site [chemical binding]; other site 698936017290 Walker B motif; other site 698936017291 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 698936017292 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 698936017293 dimerization interface [polypeptide binding]; other site 698936017294 ligand binding site [chemical binding]; other site 698936017295 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698936017296 dimerization interface [polypeptide binding]; other site 698936017297 PAS fold; Region: PAS_7; pfam12860 698936017298 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936017299 cyclase homology domain; Region: CHD; cd07302 698936017300 nucleotidyl binding site; other site 698936017301 metal binding site [ion binding]; metal-binding site 698936017302 dimer interface [polypeptide binding]; other site 698936017303 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698936017304 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698936017305 Walker A/P-loop; other site 698936017306 ATP binding site [chemical binding]; other site 698936017307 Q-loop/lid; other site 698936017308 ABC transporter signature motif; other site 698936017309 Walker B; other site 698936017310 D-loop; other site 698936017311 H-loop/switch region; other site 698936017312 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698936017313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936017314 putative PBP binding loops; other site 698936017315 dimer interface [polypeptide binding]; other site 698936017316 ABC-ATPase subunit interface; other site 698936017317 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 698936017318 NMT1-like family; Region: NMT1_2; pfam13379 698936017319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936017320 S-adenosylmethionine binding site [chemical binding]; other site 698936017321 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936017322 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 698936017323 AsnC family; Region: AsnC_trans_reg; pfam01037 698936017324 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 698936017325 SnoaL-like domain; Region: SnoaL_3; pfam13474 698936017326 formate dehydrogenase; Provisional; Region: PRK07574 698936017327 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 698936017328 dimerization interface [polypeptide binding]; other site 698936017329 ligand binding site [chemical binding]; other site 698936017330 NAD binding site [chemical binding]; other site 698936017331 catalytic site [active] 698936017332 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 698936017333 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 698936017334 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698936017335 hydrophobic ligand binding site; other site 698936017336 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 698936017337 conserved cys residue [active] 698936017338 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698936017339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936017340 glutathionine S-transferase; Provisional; Region: PRK10542 698936017341 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 698936017342 C-terminal domain interface [polypeptide binding]; other site 698936017343 GSH binding site (G-site) [chemical binding]; other site 698936017344 dimer interface [polypeptide binding]; other site 698936017345 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 698936017346 dimer interface [polypeptide binding]; other site 698936017347 N-terminal domain interface [polypeptide binding]; other site 698936017348 substrate binding pocket (H-site) [chemical binding]; other site 698936017349 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 698936017350 putative dimer interface [polypeptide binding]; other site 698936017351 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936017352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936017353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936017354 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698936017355 putative effector binding pocket; other site 698936017356 putative dimerization interface [polypeptide binding]; other site 698936017357 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698936017358 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 698936017359 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 698936017360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4334 698936017361 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936017362 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936017363 active site 698936017364 catalytic tetrad [active] 698936017365 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 698936017366 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 698936017367 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 698936017368 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936017369 cyclase homology domain; Region: CHD; cd07302 698936017370 nucleotidyl binding site; other site 698936017371 metal binding site [ion binding]; metal-binding site 698936017372 dimer interface [polypeptide binding]; other site 698936017373 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936017374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936017375 TPR motif; other site 698936017376 binding surface 698936017377 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936017378 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698936017379 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 698936017380 catalytic site [active] 698936017381 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936017382 cyclase homology domain; Region: CHD; cd07302 698936017383 nucleotidyl binding site; other site 698936017384 metal binding site [ion binding]; metal-binding site 698936017385 dimer interface [polypeptide binding]; other site 698936017386 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936017387 TPR repeat; Region: TPR_11; pfam13414 698936017388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936017389 TPR motif; other site 698936017390 binding surface 698936017391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936017392 binding surface 698936017393 TPR motif; other site 698936017394 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936017395 cyclase homology domain; Region: CHD; cd07302 698936017396 nucleotidyl binding site; other site 698936017397 metal binding site [ion binding]; metal-binding site 698936017398 dimer interface [polypeptide binding]; other site 698936017399 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936017400 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698936017401 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698936017402 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698936017403 classical (c) SDRs; Region: SDR_c; cd05233 698936017404 NAD(P) binding site [chemical binding]; other site 698936017405 active site 698936017406 Predicted membrane protein [Function unknown]; Region: COG3918 698936017407 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698936017408 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936017409 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698936017410 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 698936017411 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698936017412 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936017413 DNA binding site [nucleotide binding] 698936017414 Predicted ATPase [General function prediction only]; Region: COG3903 698936017415 AAA domain; Region: AAA_17; pfam13207 698936017416 Predicted periplasmic protein [Function unknown]; Region: COG3904 698936017417 Predicted ATPase [General function prediction only]; Region: COG3903 698936017418 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936017419 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698936017420 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 698936017421 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698936017422 MULE transposase domain; Region: MULE; pfam10551 698936017423 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 698936017424 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698936017425 catalytic site [active] 698936017426 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 698936017427 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 698936017428 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 698936017429 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 698936017430 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 698936017431 cyclase homology domain; Region: CHD; cd07302 698936017432 nucleotidyl binding site; other site 698936017433 metal binding site [ion binding]; metal-binding site 698936017434 dimer interface [polypeptide binding]; other site 698936017435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936017436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936017437 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698936017438 putative effector binding pocket; other site 698936017439 putative dimerization interface [polypeptide binding]; other site 698936017440 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936017441 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936017442 active site 698936017443 catalytic tetrad [active] 698936017444 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 698936017445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 698936017446 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936017447 TPR repeat; Region: TPR_11; pfam13414 698936017448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936017449 binding surface 698936017450 TPR motif; other site 698936017451 Predicted periplasmic protein [Function unknown]; Region: COG3900 698936017452 Uncharacterized conserved protein [Function unknown]; Region: COG5361 698936017453 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 698936017454 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 698936017455 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 698936017456 Uncharacterized conserved protein [Function unknown]; Region: COG5361 698936017457 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 698936017458 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 698936017459 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 698936017460 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 698936017461 Low-spin heme binding site [chemical binding]; other site 698936017462 Putative water exit pathway; other site 698936017463 Binuclear center (active site) [active] 698936017464 Putative proton exit pathway; other site 698936017465 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 698936017466 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 698936017467 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 698936017468 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 698936017469 Cytochrome c; Region: Cytochrom_C; pfam00034 698936017470 Cytochrome c; Region: Cytochrom_C; pfam00034 698936017471 FixH; Region: FixH; pfam05751 698936017472 Predicted integral membrane protein [Function unknown]; Region: COG5473 698936017473 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698936017474 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698936017475 metal-binding site [ion binding] 698936017476 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698936017477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936017478 motif II; other site 698936017479 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 698936017480 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 698936017481 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 698936017482 putative active site [active] 698936017483 putative NTP binding site [chemical binding]; other site 698936017484 putative nucleic acid binding site [nucleotide binding]; other site 698936017485 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 698936017486 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698936017487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698936017488 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 698936017489 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 698936017490 ligand binding site [chemical binding]; other site 698936017491 Predicted periplasmic protein [Function unknown]; Region: COG3900 698936017492 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 698936017493 amphipathic channel; other site 698936017494 Asn-Pro-Ala signature motifs; other site 698936017495 Homeodomain-like domain; Region: HTH_23; pfam13384 698936017496 Winged helix-turn helix; Region: HTH_29; pfam13551 698936017497 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698936017498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698936017499 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698936017500 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698936017501 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698936017502 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 698936017503 phosphate acetyltransferase; Provisional; Region: PRK11890 698936017504 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 698936017505 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 698936017506 propionate/acetate kinase; Provisional; Region: PRK12379 698936017507 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 698936017508 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 698936017509 NAD binding site [chemical binding]; other site 698936017510 homotetramer interface [polypeptide binding]; other site 698936017511 homodimer interface [polypeptide binding]; other site 698936017512 substrate binding site [chemical binding]; other site 698936017513 active site 698936017514 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698936017515 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698936017516 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 698936017517 FOG: CBS domain [General function prediction only]; Region: COG0517 698936017518 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 698936017519 BON domain; Region: BON; pfam04972 698936017520 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698936017521 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698936017522 NAD binding site [chemical binding]; other site 698936017523 substrate binding site [chemical binding]; other site 698936017524 catalytic Zn binding site [ion binding]; other site 698936017525 tetramer interface [polypeptide binding]; other site 698936017526 structural Zn binding site [ion binding]; other site 698936017527 putative phosphoketolase; Provisional; Region: PRK05261 698936017528 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 698936017529 TPP-binding site; other site 698936017530 XFP C-terminal domain; Region: XFP_C; pfam09363 698936017531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698936017532 catalytic core [active] 698936017533 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 698936017534 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 698936017535 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 698936017536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 698936017537 Putative glucoamylase; Region: Glycoamylase; pfam10091 698936017538 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 698936017539 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 698936017540 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 698936017541 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936017542 oxidoreductase; Provisional; Region: PRK06196 698936017543 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 698936017544 putative NAD(P) binding site [chemical binding]; other site 698936017545 active site 698936017546 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698936017547 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698936017548 NAD(P) binding site [chemical binding]; other site 698936017549 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936017550 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936017551 SnoaL-like domain; Region: SnoaL_4; pfam13577 698936017552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936017553 Response regulator receiver domain; Region: Response_reg; pfam00072 698936017554 active site 698936017555 phosphorylation site [posttranslational modification] 698936017556 intermolecular recognition site; other site 698936017557 dimerization interface [polypeptide binding]; other site 698936017558 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 698936017559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936017560 active site 698936017561 phosphorylation site [posttranslational modification] 698936017562 intermolecular recognition site; other site 698936017563 dimerization interface [polypeptide binding]; other site 698936017564 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936017565 DNA binding residues [nucleotide binding] 698936017566 dimerization interface [polypeptide binding]; other site 698936017567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936017568 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 698936017569 putative active site [active] 698936017570 heme pocket [chemical binding]; other site 698936017571 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936017572 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 698936017573 putative active site [active] 698936017574 heme pocket [chemical binding]; other site 698936017575 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936017576 putative active site [active] 698936017577 heme pocket [chemical binding]; other site 698936017578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936017579 ATP binding site [chemical binding]; other site 698936017580 Mg2+ binding site [ion binding]; other site 698936017581 G-X-G motif; other site 698936017582 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698936017583 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936017584 Tubulin like; Region: Tubulin_2; pfam13809 698936017585 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698936017586 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 698936017587 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 698936017588 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698936017589 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698936017590 catalytic residue [active] 698936017591 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 698936017592 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698936017593 putative NAD(P) binding site [chemical binding]; other site 698936017594 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936017595 BA14K-like protein; Region: BA14K; pfam07886 698936017596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698936017597 dimerization interface [polypeptide binding]; other site 698936017598 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 698936017599 cyclase homology domain; Region: CHD; cd07302 698936017600 nucleotidyl binding site; other site 698936017601 metal binding site [ion binding]; metal-binding site 698936017602 dimer interface [polypeptide binding]; other site 698936017603 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698936017604 MULE transposase domain; Region: MULE; pfam10551 698936017605 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 698936017606 Transposase domain (DUF772); Region: DUF772; pfam05598 698936017607 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 698936017608 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 698936017609 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 698936017610 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 698936017611 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 698936017612 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698936017613 ligand binding site [chemical binding]; other site 698936017614 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698936017615 putative switch regulator; other site 698936017616 non-specific DNA interactions [nucleotide binding]; other site 698936017617 DNA binding site [nucleotide binding] 698936017618 sequence specific DNA binding site [nucleotide binding]; other site 698936017619 putative cAMP binding site [chemical binding]; other site 698936017620 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936017621 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 698936017622 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 698936017623 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936017624 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698936017625 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 698936017626 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 698936017627 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 698936017628 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936017629 substrate binding pocket [chemical binding]; other site 698936017630 membrane-bound complex binding site; other site 698936017631 hinge residues; other site 698936017632 putrescine transporter; Provisional; Region: potE; PRK10655 698936017633 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698936017634 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 698936017635 ornithine decarboxylase; Provisional; Region: PRK13578 698936017636 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698936017637 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698936017638 catalytic residue [active] 698936017639 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 698936017640 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 698936017641 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 698936017642 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698936017643 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698936017644 catalytic residue [active] 698936017645 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 698936017646 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: COG3965 698936017647 arginine:agmatin antiporter; Provisional; Region: PRK10644 698936017648 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 698936017649 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 698936017650 arginine deiminase; Provisional; Region: PRK01388 698936017651 ornithine carbamoyltransferase; Validated; Region: PRK02102 698936017652 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698936017653 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698936017654 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 698936017655 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 698936017656 putative substrate binding site [chemical binding]; other site 698936017657 nucleotide binding site [chemical binding]; other site 698936017658 nucleotide binding site [chemical binding]; other site 698936017659 homodimer interface [polypeptide binding]; other site 698936017660 Ion channel; Region: Ion_trans_2; pfam07885 698936017661 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 698936017662 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 698936017663 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698936017664 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698936017665 inhibitor site; inhibition site 698936017666 active site 698936017667 dimer interface [polypeptide binding]; other site 698936017668 catalytic residue [active] 698936017669 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 698936017670 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 698936017671 active site pocket [active] 698936017672 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936017673 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698936017674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936017675 dimer interface [polypeptide binding]; other site 698936017676 conserved gate region; other site 698936017677 putative PBP binding loops; other site 698936017678 ABC-ATPase subunit interface; other site 698936017679 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936017680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936017681 dimer interface [polypeptide binding]; other site 698936017682 conserved gate region; other site 698936017683 putative PBP binding loops; other site 698936017684 ABC-ATPase subunit interface; other site 698936017685 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698936017686 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936017687 Walker A/P-loop; other site 698936017688 ATP binding site [chemical binding]; other site 698936017689 Q-loop/lid; other site 698936017690 ABC transporter signature motif; other site 698936017691 Walker B; other site 698936017692 D-loop; other site 698936017693 H-loop/switch region; other site 698936017694 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698936017695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936017696 NAD(P) binding site [chemical binding]; other site 698936017697 active site 698936017698 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698936017699 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 698936017700 Bacterial transcriptional regulator; Region: IclR; pfam01614 698936017701 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 698936017702 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936017703 classical (c) SDRs; Region: SDR_c; cd05233 698936017704 NAD(P) binding site [chemical binding]; other site 698936017705 active site 698936017706 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 698936017707 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 698936017708 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698936017709 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 698936017710 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698936017711 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698936017712 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698936017713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936017714 dimer interface [polypeptide binding]; other site 698936017715 conserved gate region; other site 698936017716 putative PBP binding loops; other site 698936017717 ABC-ATPase subunit interface; other site 698936017718 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936017719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936017720 dimer interface [polypeptide binding]; other site 698936017721 conserved gate region; other site 698936017722 putative PBP binding loops; other site 698936017723 ABC-ATPase subunit interface; other site 698936017724 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698936017725 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698936017726 active site 698936017727 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 698936017728 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698936017729 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 698936017730 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 698936017731 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 698936017732 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698936017733 Ligand Binding Site [chemical binding]; other site 698936017734 Molecular Tunnel; other site 698936017735 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 698936017736 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 698936017737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936017738 Walker A motif; other site 698936017739 ATP binding site [chemical binding]; other site 698936017740 Walker B motif; other site 698936017741 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698936017742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 698936017743 Integrase core domain; Region: rve; pfam00665 698936017744 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 698936017745 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 698936017746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698936017747 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 698936017748 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698936017749 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 698936017750 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698936017751 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 698936017752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698936017753 Transposase; Region: HTH_Tnp_1; pfam01527 698936017754 Predicted transcriptional regulator [Transcription]; Region: COG4957 698936017755 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936017756 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936017757 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936017758 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936017759 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 698936017760 putative active site [active] 698936017761 YdjC motif; other site 698936017762 Mg binding site [ion binding]; other site 698936017763 homodimer interface [polypeptide binding]; other site 698936017764 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698936017765 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698936017766 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698936017767 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 698936017768 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698936017769 putative ligand binding site [chemical binding]; other site 698936017770 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698936017771 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936017772 DNA-binding site [nucleotide binding]; DNA binding site 698936017773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936017774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936017775 homodimer interface [polypeptide binding]; other site 698936017776 catalytic residue [active] 698936017777 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698936017778 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 698936017779 putative di-iron ligands [ion binding]; other site 698936017780 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 698936017781 [2Fe-2S] cluster binding site [ion binding]; other site 698936017782 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 698936017783 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698936017784 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 698936017785 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 698936017786 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 698936017787 putative active site [active] 698936017788 putative substrate binding site [chemical binding]; other site 698936017789 putative cosubstrate binding site; other site 698936017790 catalytic site [active] 698936017791 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698936017792 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 698936017793 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698936017794 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698936017795 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 698936017796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936017797 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698936017798 putative substrate translocation pore; other site 698936017799 Nitrogen fixation protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NifU; COG5554 698936017800 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 698936017801 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 698936017802 inhibitor-cofactor binding pocket; inhibition site 698936017803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936017804 catalytic residue [active] 698936017805 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 698936017806 Ligand Binding Site [chemical binding]; other site 698936017807 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936017808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936017809 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 698936017810 putative substrate binding pocket [chemical binding]; other site 698936017811 putative dimerization interface [polypeptide binding]; other site 698936017812 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 698936017813 Transposase domain (DUF772); Region: DUF772; pfam05598 698936017814 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 698936017815 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698936017816 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936017817 non-specific DNA binding site [nucleotide binding]; other site 698936017818 salt bridge; other site 698936017819 sequence-specific DNA binding site [nucleotide binding]; other site 698936017820 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698936017821 oligomeric interface; other site 698936017822 putative active site [active] 698936017823 homodimer interface [polypeptide binding]; other site 698936017824 prevent-host-death family protein; Region: phd_fam; TIGR01552 698936017825 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 698936017826 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 698936017827 nudix motif; other site 698936017828 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698936017829 DNA-binding site [nucleotide binding]; DNA binding site 698936017830 RNA-binding motif; other site 698936017831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936017832 non-specific DNA binding site [nucleotide binding]; other site 698936017833 salt bridge; other site 698936017834 sequence-specific DNA binding site [nucleotide binding]; other site 698936017835 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 698936017836 Transposase domain (DUF772); Region: DUF772; pfam05598 698936017837 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 698936017838 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698936017839 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 698936017840 Omptin family; Region: Omptin; cl01886 698936017841 Omptin family; Region: Omptin; cl01886 698936017842 Predicted transcriptional regulator [Transcription]; Region: COG4957 698936017843 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698936017844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936017845 S-adenosylmethionine binding site [chemical binding]; other site 698936017846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698936017847 Transposase; Region: HTH_Tnp_1; pfam01527 698936017848 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 698936017849 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 698936017850 dimer interface [polypeptide binding]; other site 698936017851 PYR/PP interface [polypeptide binding]; other site 698936017852 TPP binding site [chemical binding]; other site 698936017853 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698936017854 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 698936017855 TPP-binding site [chemical binding]; other site 698936017856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 698936017857 Homeodomain-like domain; Region: HTH_23; pfam13384 698936017858 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698936017859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698936017860 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698936017861 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936017862 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936017863 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 698936017864 Ferritin-like; Region: Ferritin-like; pfam12902 698936017865 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 698936017866 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698936017867 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698936017868 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 698936017869 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 698936017870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936017871 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936017872 dimerization interface [polypeptide binding]; other site 698936017873 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 698936017874 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 698936017875 [2Fe-2S] cluster binding site [ion binding]; other site 698936017876 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 698936017877 putative alpha subunit interface [polypeptide binding]; other site 698936017878 putative active site [active] 698936017879 putative substrate binding site [chemical binding]; other site 698936017880 Fe binding site [ion binding]; other site 698936017881 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698936017882 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 698936017883 FAD binding pocket [chemical binding]; other site 698936017884 FAD binding motif [chemical binding]; other site 698936017885 phosphate binding motif [ion binding]; other site 698936017886 beta-alpha-beta structure motif; other site 698936017887 NAD binding pocket [chemical binding]; other site 698936017888 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936017889 catalytic loop [active] 698936017890 iron binding site [ion binding]; other site 698936017891 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 698936017892 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 698936017893 B3/4 domain; Region: B3_4; pfam03483 698936017894 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 698936017895 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698936017896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936017897 DNA-binding site [nucleotide binding]; DNA binding site 698936017898 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936017899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936017900 homodimer interface [polypeptide binding]; other site 698936017901 catalytic residue [active] 698936017902 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698936017903 MULE transposase domain; Region: MULE; pfam10551 698936017904 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698936017905 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698936017906 catalytic residue [active] 698936017907 type IV secretion system pilin subunit VirB2; Provisional; Region: PRK13857 698936017908 type IV secretion system protein VirB3; Provisional; Region: PRK13854 698936017909 type IV secretion system protein VirB4; Provisional; Region: PRK13853 698936017910 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 698936017911 type IV secretion system protein VirB5; Provisional; Region: PRK13860 698936017912 Domain of unknown function (DUF4141); Region: DUF4141; pfam13605 698936017913 type IV secretion system protein VirB6; Provisional; Region: PRK13852 698936017914 type IV secretion system lipoprotein VirB7; Provisional; Region: PRK13859 698936017915 type IV secretion system protein VirB8; Provisional; Region: PRK13865 698936017916 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 698936017917 VirB7 interaction site; other site 698936017918 type IV secretion system protein VirB10; Provisional; Region: PRK13855 698936017919 type IV secretion system protein VirB11; Provisional; Region: PRK13851 698936017920 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698936017921 Walker A motif; other site 698936017922 hexamer interface [polypeptide binding]; other site 698936017923 ATP binding site [chemical binding]; other site 698936017924 Walker B motif; other site 698936017925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698936017926 Transposase; Region: HTH_Tnp_1; pfam01527 698936017927 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698936017928 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 698936017929 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 698936017930 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698936017931 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 698936017932 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698936017933 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 698936017934 two-component response regulator VirG; Provisional; Region: PRK13856 698936017935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936017936 active site 698936017937 phosphorylation site [posttranslational modification] 698936017938 intermolecular recognition site; other site 698936017939 dimerization interface [polypeptide binding]; other site 698936017940 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936017941 DNA binding site [nucleotide binding] 698936017942 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 698936017943 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 698936017944 Walker A motif; other site 698936017945 ATP binding site [chemical binding]; other site 698936017946 Walker B motif; other site 698936017947 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698936017948 MULE transposase domain; Region: MULE; pfam10551 698936017949 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 698936017950 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698936017951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936017952 non-specific DNA binding site [nucleotide binding]; other site 698936017953 salt bridge; other site 698936017954 sequence-specific DNA binding site [nucleotide binding]; other site 698936017955 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 698936017956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936017957 sequence-specific DNA binding site [nucleotide binding]; other site 698936017958 salt bridge; other site 698936017959 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 698936017960 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 698936017961 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698936017962 ligand binding site [chemical binding]; other site 698936017963 flexible hinge region; other site 698936017964 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698936017965 putative switch regulator; other site 698936017966 non-specific DNA interactions [nucleotide binding]; other site 698936017967 DNA binding site [nucleotide binding] 698936017968 sequence specific DNA binding site [nucleotide binding]; other site 698936017969 putative cAMP binding site [chemical binding]; other site 698936017970 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 698936017971 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 698936017972 Low-spin heme binding site [chemical binding]; other site 698936017973 Putative water exit pathway; other site 698936017974 Binuclear center (active site) [active] 698936017975 Putative proton exit pathway; other site 698936017976 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 698936017977 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 698936017978 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 698936017979 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 698936017980 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698936017981 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698936017982 maltose O-acetyltransferase; Provisional; Region: PRK10092 698936017983 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 698936017984 active site 698936017985 substrate binding site [chemical binding]; other site 698936017986 trimer interface [polypeptide binding]; other site 698936017987 CoA binding site [chemical binding]; other site 698936017988 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 698936017989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936017990 S-adenosylmethionine binding site [chemical binding]; other site 698936017991 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936017992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936017993 DNA-binding site [nucleotide binding]; DNA binding site 698936017994 FCD domain; Region: FCD; pfam07729 698936017995 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698936017996 MULE transposase domain; Region: MULE; pfam10551 698936017997 Amino acid synthesis; Region: AA_synth; pfam06684 698936017998 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698936017999 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 698936018000 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698936018001 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 698936018002 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698936018003 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 698936018004 NAD(P) binding site [chemical binding]; other site 698936018005 catalytic residues [active] 698936018006 NIPSNAP; Region: NIPSNAP; pfam07978 698936018007 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698936018008 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936018009 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 698936018010 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936018011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936018012 putative PBP binding loops; other site 698936018013 ABC-ATPase subunit interface; other site 698936018014 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698936018015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936018016 Walker A/P-loop; other site 698936018017 ATP binding site [chemical binding]; other site 698936018018 Q-loop/lid; other site 698936018019 ABC transporter signature motif; other site 698936018020 Walker B; other site 698936018021 D-loop; other site 698936018022 H-loop/switch region; other site 698936018023 TOBE domain; Region: TOBE_2; pfam08402 698936018024 succinic semialdehyde dehydrogenase; Region: PLN02278 698936018025 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698936018026 tetramerization interface [polypeptide binding]; other site 698936018027 NAD(P) binding site [chemical binding]; other site 698936018028 catalytic residues [active] 698936018029 Transposase; Region: HTH_Tnp_1; cl17663 698936018030 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698936018031 MULE transposase domain; Region: MULE; pfam10551 698936018032 Nitrogen fixation protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NifU; COG5554 698936018033 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 698936018034 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 698936018035 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698936018036 FeS/SAM binding site; other site 698936018037 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 698936018038 Nif-specific regulatory protein; Region: nifA; TIGR01817 698936018039 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698936018040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936018041 Walker A motif; other site 698936018042 ATP binding site [chemical binding]; other site 698936018043 Walker B motif; other site 698936018044 arginine finger; other site 698936018045 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 698936018046 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 698936018047 oxidoreductase; Provisional; Region: PRK10015 698936018048 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698936018049 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698936018050 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698936018051 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698936018052 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698936018053 Ligand binding site [chemical binding]; other site 698936018054 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698936018055 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 698936018056 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 698936018057 Nucleotide-binding sites [chemical binding]; other site 698936018058 Walker A motif; other site 698936018059 Switch I region of nucleotide binding site; other site 698936018060 Fe4S4 binding sites [ion binding]; other site 698936018061 Switch II region of nucleotide binding site; other site 698936018062 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 698936018063 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 698936018064 MoFe protein alpha/beta subunit interactions; other site 698936018065 Alpha subunit P cluster binding residues; other site 698936018066 FeMoco binding residues [chemical binding]; other site 698936018067 MoFe protein alpha subunit/Fe protein contacts; other site 698936018068 MoFe protein dimer/ dimer interactions; other site 698936018069 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 698936018070 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 698936018071 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 698936018072 MoFe protein beta/alpha subunit interactions; other site 698936018073 Beta subunit P cluster binding residues; other site 698936018074 MoFe protein beta subunit/Fe protein contacts; other site 698936018075 MoFe protein dimer/ dimer interactions; other site 698936018076 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 698936018077 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 698936018078 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 698936018079 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5420 698936018080 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 698936018081 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 698936018082 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698936018083 Exopolysaccharide production repressor; Region: SyrA; pfam11089 698936018084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936018085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936018086 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 698936018087 putative substrate binding pocket [chemical binding]; other site 698936018088 putative dimerization interface [polypeptide binding]; other site 698936018089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936018090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936018091 The C-terminal substrate binding of LysR-type symbiotic regulator SyrM, which activates expression of nodulation gene NodD3, contains the type 2 periplasmic binding fold; Region: PBP2_SyrM; cd08467 698936018092 putative substrate binding pocket [chemical binding]; other site 698936018093 putative dimerization interface [polypeptide binding]; other site 698936018094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 698936018095 Homeodomain-like domain; Region: HTH_23; pfam13384 698936018096 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698936018097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698936018098 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 698936018099 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 698936018100 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 698936018101 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 698936018102 dimer interface [polypeptide binding]; other site 698936018103 active site 698936018104 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 698936018105 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 698936018106 NAD(P) binding site [chemical binding]; other site 698936018107 homotetramer interface [polypeptide binding]; other site 698936018108 homodimer interface [polypeptide binding]; other site 698936018109 active site 698936018110 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 698936018111 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 698936018112 Active Sites [active] 698936018113 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 698936018114 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 698936018115 CysD dimerization site [polypeptide binding]; other site 698936018116 G1 box; other site 698936018117 putative GEF interaction site [polypeptide binding]; other site 698936018118 GTP/Mg2+ binding site [chemical binding]; other site 698936018119 Switch I region; other site 698936018120 G2 box; other site 698936018121 G3 box; other site 698936018122 Switch II region; other site 698936018123 G4 box; other site 698936018124 G5 box; other site 698936018125 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 698936018126 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 698936018127 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 698936018128 ligand-binding site [chemical binding]; other site 698936018129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 698936018130 Homeodomain-like domain; Region: HTH_23; pfam13384 698936018131 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698936018132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698936018133 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698936018134 MULE transposase domain; Region: MULE; pfam10551 698936018135 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 698936018136 ABC-2 type transporter, NodJ family; Region: nodJ; TIGR01291 698936018137 nodulation factor exporter subunit NodI; Provisional; Region: PRK13536 698936018138 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 698936018139 Walker A/P-loop; other site 698936018140 ATP binding site [chemical binding]; other site 698936018141 Q-loop/lid; other site 698936018142 ABC transporter signature motif; other site 698936018143 Walker B; other site 698936018144 D-loop; other site 698936018145 H-loop/switch region; other site 698936018146 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 698936018147 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 698936018148 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 698936018149 DXD motif; other site 698936018150 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698936018151 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 698936018152 Nodulation protein A (NodA); Region: NodA; pfam02474 698936018153 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936018154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936018155 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 698936018156 putative substrate binding pocket [chemical binding]; other site 698936018157 putative dimerization interface [polypeptide binding]; other site 698936018158 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 698936018159 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 698936018160 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 698936018161 putative active site [active] 698936018162 putative catalytic site [active] 698936018163 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698936018164 Protein export membrane protein; Region: SecD_SecF; cl14618 698936018165 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698936018166 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936018167 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698936018168 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698936018169 glutaminase active site [active] 698936018170 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698936018171 dimer interface [polypeptide binding]; other site 698936018172 active site 698936018173 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698936018174 dimer interface [polypeptide binding]; other site 698936018175 active site 698936018176 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698936018177 Uncharacterized conserved protein [Function unknown]; Region: COG4544 698936018178 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698936018179 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 698936018180 putative active site [active] 698936018181 putative PHP Thumb interface [polypeptide binding]; other site 698936018182 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698936018183 generic binding surface I; other site 698936018184 generic binding surface II; other site 698936018185 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 698936018186 Antirestriction protein; Region: Antirestrict; pfam03230 698936018187 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 698936018188 Helicase_C-like; Region: Helicase_C_4; pfam13871 698936018189 Toprim domain; Region: Toprim_3; pfam13362 698936018190 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 698936018191 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 698936018192 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 698936018193 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 698936018194 Walker A motif; other site 698936018195 ATP binding site [chemical binding]; other site 698936018196 Walker B motif; other site 698936018197 Conjugal transfer protein TraD; Region: TraD; pfam06412 698936018198 TraC-like protein; Region: TraC; pfam07820 698936018199 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 698936018200 MobA/MobL family; Region: MobA_MobL; pfam03389 698936018201 AAA domain; Region: AAA_30; pfam13604 698936018202 Family description; Region: UvrD_C_2; pfam13538 698936018203 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698936018204 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698936018205 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936018206 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936018207 dimer interface [polypeptide binding]; other site 698936018208 phosphorylation site [posttranslational modification] 698936018209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936018210 ATP binding site [chemical binding]; other site 698936018211 Mg2+ binding site [ion binding]; other site 698936018212 G-X-G motif; other site 698936018213 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 698936018214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936018215 active site 698936018216 phosphorylation site [posttranslational modification] 698936018217 intermolecular recognition site; other site 698936018218 dimerization interface [polypeptide binding]; other site 698936018219 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936018220 DNA binding residues [nucleotide binding] 698936018221 dimerization interface [polypeptide binding]; other site 698936018222 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698936018223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936018224 active site 698936018225 phosphorylation site [posttranslational modification] 698936018226 intermolecular recognition site; other site 698936018227 dimerization interface [polypeptide binding]; other site 698936018228 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 698936018229 Sulfatase; Region: Sulfatase; pfam00884 698936018230 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 698936018231 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 698936018232 metal binding site [ion binding]; metal-binding site 698936018233 dimer interface [polypeptide binding]; other site 698936018234 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 698936018235 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 698936018236 putative active site [active] 698936018237 putative metal binding site [ion binding]; other site 698936018238 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; pfam09587 698936018239 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698936018240 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936018241 Walker A/P-loop; other site 698936018242 ATP binding site [chemical binding]; other site 698936018243 Q-loop/lid; other site 698936018244 ABC transporter signature motif; other site 698936018245 Walker B; other site 698936018246 D-loop; other site 698936018247 H-loop/switch region; other site 698936018248 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936018249 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936018250 Walker A/P-loop; other site 698936018251 ATP binding site [chemical binding]; other site 698936018252 Q-loop/lid; other site 698936018253 ABC transporter signature motif; other site 698936018254 Walker B; other site 698936018255 D-loop; other site 698936018256 H-loop/switch region; other site 698936018257 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936018258 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698936018259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936018260 dimer interface [polypeptide binding]; other site 698936018261 conserved gate region; other site 698936018262 putative PBP binding loops; other site 698936018263 ABC-ATPase subunit interface; other site 698936018264 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936018265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936018266 dimer interface [polypeptide binding]; other site 698936018267 conserved gate region; other site 698936018268 putative PBP binding loops; other site 698936018269 ABC-ATPase subunit interface; other site 698936018270 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936018271 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 698936018272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698936018273 non-specific DNA binding site [nucleotide binding]; other site 698936018274 salt bridge; other site 698936018275 sequence-specific DNA binding site [nucleotide binding]; other site 698936018276 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698936018277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936018278 Coenzyme A binding pocket [chemical binding]; other site 698936018279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936018280 S-adenosylmethionine binding site [chemical binding]; other site 698936018281 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698936018282 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936018283 DNA binding residues [nucleotide binding] 698936018284 dimerization interface [polypeptide binding]; other site 698936018285 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 698936018286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 698936018287 active site 698936018288 phosphorylation site [posttranslational modification] 698936018289 dimerization interface [polypeptide binding]; other site 698936018290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698936018291 DNA binding site [nucleotide binding] 698936018292 transcriptional regulator TraR; Provisional; Region: PRK13870 698936018293 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698936018294 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936018295 DNA binding residues [nucleotide binding] 698936018296 Helix-turn-helix domain; Region: HTH_28; pfam13518 698936018297 Winged helix-turn helix; Region: HTH_29; pfam13551 698936018298 Homeodomain-like domain; Region: HTH_32; pfam13565 698936018299 Integrase core domain; Region: rve; pfam00665 698936018300 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698936018301 Helix-turn-helix domain; Region: HTH_38; pfam13936 698936018302 Homeodomain-like domain; Region: HTH_32; pfam13565 698936018303 Integrase core domain; Region: rve; pfam00665 698936018304 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 698936018305 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 698936018306 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 698936018307 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698936018308 oligomeric interface; other site 698936018309 putative active site [active] 698936018310 homodimer interface [polypeptide binding]; other site 698936018311 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 698936018312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936018313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936018314 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936018315 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936018316 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698936018317 putative effector binding pocket; other site 698936018318 putative dimerization interface [polypeptide binding]; other site 698936018319 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936018320 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936018321 active site 698936018322 catalytic tetrad [active] 698936018323 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 698936018324 active site 1 [active] 698936018325 dimer interface [polypeptide binding]; other site 698936018326 hexamer interface [polypeptide binding]; other site 698936018327 active site 2 [active] 698936018328 short chain dehydrogenase; Provisional; Region: PRK12937 698936018329 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 698936018330 NADP binding site [chemical binding]; other site 698936018331 homodimer interface [polypeptide binding]; other site 698936018332 active site 698936018333 substrate binding site [chemical binding]; other site 698936018334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936018335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936018336 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 698936018337 putative effector binding pocket; other site 698936018338 putative dimerization interface [polypeptide binding]; other site 698936018339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698936018340 Uncharacterized conserved protein [Function unknown]; Region: COG1633 698936018341 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 698936018342 diiron binding motif [ion binding]; other site 698936018343 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 698936018344 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 698936018345 4Fe-4S binding domain; Region: Fer4_5; pfam12801 698936018346 4Fe-4S binding domain; Region: Fer4_5; pfam12801 698936018347 nitrous-oxide reductase; Validated; Region: PRK02888 698936018348 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698936018349 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 698936018350 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 698936018351 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698936018352 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698936018353 Walker A/P-loop; other site 698936018354 ATP binding site [chemical binding]; other site 698936018355 Q-loop/lid; other site 698936018356 ABC transporter signature motif; other site 698936018357 Walker B; other site 698936018358 D-loop; other site 698936018359 H-loop/switch region; other site 698936018360 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 698936018361 Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314 698936018362 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 698936018363 ApbE family; Region: ApbE; pfam02424 698936018364 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 698936018365 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 698936018366 heme-binding site [chemical binding]; other site 698936018367 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 698936018368 FAD binding pocket [chemical binding]; other site 698936018369 FAD binding motif [chemical binding]; other site 698936018370 phosphate binding motif [ion binding]; other site 698936018371 beta-alpha-beta structure motif; other site 698936018372 NAD binding pocket [chemical binding]; other site 698936018373 Heme binding pocket [chemical binding]; other site 698936018374 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 698936018375 Regulator of cell morphogenesis and NO signaling [Cell division and chromosome partitioning]; Region: COG2846 698936018376 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 698936018377 Hemerythrin-like domain; Region: Hr-like; cd12108 698936018378 Fe binding site [ion binding]; other site 698936018379 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 698936018380 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 698936018381 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 698936018382 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698936018383 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698936018384 ligand binding site [chemical binding]; other site 698936018385 flexible hinge region; other site 698936018386 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 698936018387 cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847 698936018388 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698936018389 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698936018390 metal-binding site [ion binding] 698936018391 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698936018392 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698936018393 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 698936018394 FixH; Region: FixH; pfam05751 698936018395 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 698936018396 4Fe-4S binding domain; Region: Fer4_5; pfam12801 698936018397 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 698936018398 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 698936018399 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698936018400 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698936018401 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 698936018402 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 698936018403 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 698936018404 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 698936018405 Low-spin heme binding site [chemical binding]; other site 698936018406 Putative water exit pathway; other site 698936018407 Binuclear center (active site) [active] 698936018408 Putative proton exit pathway; other site 698936018409 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 698936018410 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 698936018411 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698936018412 ligand binding site [chemical binding]; other site 698936018413 flexible hinge region; other site 698936018414 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698936018415 putative switch regulator; other site 698936018416 non-specific DNA interactions [nucleotide binding]; other site 698936018417 DNA binding site [nucleotide binding] 698936018418 sequence specific DNA binding site [nucleotide binding]; other site 698936018419 putative cAMP binding site [chemical binding]; other site 698936018420 response regulator FixJ; Provisional; Region: fixJ; PRK09390 698936018421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936018422 active site 698936018423 phosphorylation site [posttranslational modification] 698936018424 intermolecular recognition site; other site 698936018425 dimerization interface [polypeptide binding]; other site 698936018426 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936018427 DNA binding residues [nucleotide binding] 698936018428 dimerization interface [polypeptide binding]; other site 698936018429 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 698936018430 PAS domain S-box; Region: sensory_box; TIGR00229 698936018431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936018432 putative active site [active] 698936018433 heme pocket [chemical binding]; other site 698936018434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936018435 dimer interface [polypeptide binding]; other site 698936018436 phosphorylation site [posttranslational modification] 698936018437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936018438 ATP binding site [chemical binding]; other site 698936018439 Mg2+ binding site [ion binding]; other site 698936018440 G-X-G motif; other site 698936018441 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698936018442 Ligand Binding Site [chemical binding]; other site 698936018443 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 698936018444 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 698936018445 Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043 698936018446 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 698936018447 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 698936018448 [4Fe-4S] binding site [ion binding]; other site 698936018449 molybdopterin cofactor binding site; other site 698936018450 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 698936018451 molybdopterin cofactor binding site; other site 698936018452 Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062 698936018453 ferredoxin-type protein; Provisional; Region: PRK10194 698936018454 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 698936018455 4Fe-4S binding domain; Region: Fer4; pfam00037 698936018456 Periplasmic nitrate reductase system, NapE component [Energy production and conversion]; Region: NapE; COG4459 698936018457 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 698936018458 pseudoazurin; Region: pseudoazurin; TIGR02375 698936018459 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698936018460 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698936018461 ligand binding site [chemical binding]; other site 698936018462 flexible hinge region; other site 698936018463 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698936018464 putative switch regulator; other site 698936018465 non-specific DNA interactions [nucleotide binding]; other site 698936018466 DNA binding site [nucleotide binding] 698936018467 sequence specific DNA binding site [nucleotide binding]; other site 698936018468 putative cAMP binding site [chemical binding]; other site 698936018469 Uncharacterized conserved protein [Function unknown]; Region: COG1262 698936018470 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 698936018471 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 698936018472 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698936018473 Multicopper oxidase; Region: Cu-oxidase; pfam00394 698936018474 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 698936018475 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698936018476 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 698936018477 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 698936018478 Uncharacterized conserved protein [Function unknown]; Region: COG4309 698936018479 Pirin-related protein [General function prediction only]; Region: COG1741 698936018480 Pirin; Region: Pirin; pfam02678 698936018481 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 698936018482 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698936018483 FeS/SAM binding site; other site 698936018484 HemN C-terminal domain; Region: HemN_C; pfam06969 698936018485 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 698936018486 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 698936018487 metal ion-dependent adhesion site (MIDAS); other site 698936018488 MoxR-like ATPases [General function prediction only]; Region: COG0714 698936018489 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 698936018490 Walker A motif; other site 698936018491 ATP binding site [chemical binding]; other site 698936018492 Walker B motif; other site 698936018493 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 698936018494 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 698936018495 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 698936018496 D-pathway; other site 698936018497 K-pathway; other site 698936018498 Binuclear center (active site) [active] 698936018499 Putative proton exit pathway; other site 698936018500 Cytochrome c; Region: Cytochrom_C; pfam00034 698936018501 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 698936018502 Subunit I/III interface [polypeptide binding]; other site 698936018503 Predicted membrane protein [Function unknown]; Region: COG4094 698936018504 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 698936018505 Flavoprotein; Region: Flavoprotein; pfam02441 698936018506 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 698936018507 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 698936018508 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 698936018509 Peptidase family U32; Region: Peptidase_U32; pfam01136 698936018510 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 698936018511 putative protease; Provisional; Region: PRK15447 698936018512 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698936018513 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698936018514 NAD binding site [chemical binding]; other site 698936018515 substrate binding site [chemical binding]; other site 698936018516 catalytic Zn binding site [ion binding]; other site 698936018517 tetramer interface [polypeptide binding]; other site 698936018518 structural Zn binding site [ion binding]; other site 698936018519 Predicted membrane protein [Function unknown]; Region: COG3619 698936018520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936018521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936018522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936018523 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698936018524 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 698936018525 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698936018526 Walker A motif; other site 698936018527 hexamer interface [polypeptide binding]; other site 698936018528 ATP binding site [chemical binding]; other site 698936018529 Walker B motif; other site 698936018530 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 698936018531 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 698936018532 VirB7 interaction site; other site 698936018533 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 698936018534 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 698936018535 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 698936018536 Type IV secretion system proteins; Region: T4SS; pfam07996 698936018537 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 698936018538 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 698936018539 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 698936018540 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 698936018541 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698936018542 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698936018543 RibD C-terminal domain; Region: RibD_C; cl17279 698936018544 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698936018545 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936018546 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 698936018547 TAP-like protein; Region: Abhydrolase_4; pfam08386 698936018548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936018549 metabolite-proton symporter; Region: 2A0106; TIGR00883 698936018550 putative substrate translocation pore; other site 698936018551 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698936018552 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698936018553 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 698936018554 active site 698936018555 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 698936018556 Cupin domain; Region: Cupin_2; pfam07883 698936018557 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 698936018558 Uncharacterized conserved protein [Function unknown]; Region: COG5441 698936018559 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 698936018560 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936018561 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698936018562 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 698936018563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936018564 conserved gate region; other site 698936018565 dimer interface [polypeptide binding]; other site 698936018566 putative PBP binding loops; other site 698936018567 ABC-ATPase subunit interface; other site 698936018568 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936018569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936018570 dimer interface [polypeptide binding]; other site 698936018571 conserved gate region; other site 698936018572 putative PBP binding loops; other site 698936018573 ABC-ATPase subunit interface; other site 698936018574 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698936018575 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936018576 Walker A/P-loop; other site 698936018577 ATP binding site [chemical binding]; other site 698936018578 Q-loop/lid; other site 698936018579 ABC transporter signature motif; other site 698936018580 Walker B; other site 698936018581 D-loop; other site 698936018582 H-loop/switch region; other site 698936018583 TOBE domain; Region: TOBE_2; pfam08402 698936018584 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698936018585 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698936018586 Walker A/P-loop; other site 698936018587 ATP binding site [chemical binding]; other site 698936018588 Q-loop/lid; other site 698936018589 ABC transporter signature motif; other site 698936018590 Walker B; other site 698936018591 D-loop; other site 698936018592 H-loop/switch region; other site 698936018593 TOBE domain; Region: TOBE_2; pfam08402 698936018594 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698936018595 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698936018596 ligand binding site [chemical binding]; other site 698936018597 NAD binding site [chemical binding]; other site 698936018598 dimerization interface [polypeptide binding]; other site 698936018599 catalytic site [active] 698936018600 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936018601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936018602 DNA-binding site [nucleotide binding]; DNA binding site 698936018603 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698936018604 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 698936018605 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 698936018606 active site pocket [active] 698936018607 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936018608 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 698936018609 DNA interaction; other site 698936018610 Metal-binding active site; metal-binding site 698936018611 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698936018612 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 698936018613 Metal-binding active site; metal-binding site 698936018614 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 698936018615 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 698936018616 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936018617 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698936018618 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698936018619 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 698936018620 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698936018621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936018622 dimer interface [polypeptide binding]; other site 698936018623 conserved gate region; other site 698936018624 putative PBP binding loops; other site 698936018625 ABC-ATPase subunit interface; other site 698936018626 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 698936018627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936018628 dimer interface [polypeptide binding]; other site 698936018629 putative PBP binding loops; other site 698936018630 ABC-ATPase subunit interface; other site 698936018631 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698936018632 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698936018633 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698936018634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936018635 H-loop/switch region; other site 698936018636 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936018637 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 698936018638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936018639 NAD(P) binding site [chemical binding]; other site 698936018640 active site 698936018641 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 698936018642 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936018643 Walker A/P-loop; other site 698936018644 ATP binding site [chemical binding]; other site 698936018645 Q-loop/lid; other site 698936018646 ABC transporter signature motif; other site 698936018647 Walker B; other site 698936018648 D-loop; other site 698936018649 H-loop/switch region; other site 698936018650 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 698936018651 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698936018652 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936018653 Walker A/P-loop; other site 698936018654 ATP binding site [chemical binding]; other site 698936018655 Q-loop/lid; other site 698936018656 ABC transporter signature motif; other site 698936018657 Walker B; other site 698936018658 D-loop; other site 698936018659 H-loop/switch region; other site 698936018660 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936018661 dipeptide transporter; Provisional; Region: PRK10913 698936018662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936018663 dimer interface [polypeptide binding]; other site 698936018664 conserved gate region; other site 698936018665 putative PBP binding loops; other site 698936018666 ABC-ATPase subunit interface; other site 698936018667 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936018668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936018669 dimer interface [polypeptide binding]; other site 698936018670 conserved gate region; other site 698936018671 putative PBP binding loops; other site 698936018672 ABC-ATPase subunit interface; other site 698936018673 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936018674 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 698936018675 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698936018676 Amidase; Region: Amidase; cl11426 698936018677 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936018678 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 698936018679 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 698936018680 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 698936018681 catalytic loop [active] 698936018682 iron binding site [ion binding]; other site 698936018683 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936018684 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698936018685 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936018686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936018687 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698936018688 dimerization interface [polypeptide binding]; other site 698936018689 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698936018690 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698936018691 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698936018692 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698936018693 Ligand binding site [chemical binding]; other site 698936018694 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698936018695 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 698936018696 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 698936018697 Metal-binding active site; metal-binding site 698936018698 Protein of unknown function (DUF993); Region: DUF993; pfam06187 698936018699 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 698936018700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936018701 NAD(P) binding site [chemical binding]; other site 698936018702 active site 698936018703 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698936018704 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698936018705 active site 698936018706 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936018707 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936018708 active site 698936018709 catalytic tetrad [active] 698936018710 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 698936018711 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 698936018712 MOFRL family; Region: MOFRL; pfam05161 698936018713 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698936018714 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698936018715 substrate binding site [chemical binding]; other site 698936018716 oxyanion hole (OAH) forming residues; other site 698936018717 trimer interface [polypeptide binding]; other site 698936018718 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 698936018719 Coenzyme A transferase; Region: CoA_trans; smart00882 698936018720 Coenzyme A transferase; Region: CoA_trans; cl17247 698936018721 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698936018722 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698936018723 active site 698936018724 catalytic tetrad [active] 698936018725 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 698936018726 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 698936018727 choline dehydrogenase; Validated; Region: PRK02106 698936018728 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698936018729 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698936018730 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 698936018731 NAD(P) binding site [chemical binding]; other site 698936018732 catalytic residues [active] 698936018733 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698936018734 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698936018735 NAD(P) binding site [chemical binding]; other site 698936018736 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936018737 TM-ABC transporter signature motif; other site 698936018738 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698936018739 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936018740 Walker A/P-loop; other site 698936018741 ATP binding site [chemical binding]; other site 698936018742 Q-loop/lid; other site 698936018743 ABC transporter signature motif; other site 698936018744 Walker B; other site 698936018745 D-loop; other site 698936018746 H-loop/switch region; other site 698936018747 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936018748 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936018749 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698936018750 TM-ABC transporter signature motif; other site 698936018751 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698936018752 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 698936018753 ligand binding site [chemical binding]; other site 698936018754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936018755 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936018756 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698936018757 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 698936018758 putative NAD(P) binding site [chemical binding]; other site 698936018759 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936018760 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698936018761 active site 698936018762 metal binding site [ion binding]; metal-binding site 698936018763 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698936018764 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936018765 Walker A/P-loop; other site 698936018766 ATP binding site [chemical binding]; other site 698936018767 Q-loop/lid; other site 698936018768 ABC transporter signature motif; other site 698936018769 Walker B; other site 698936018770 D-loop; other site 698936018771 H-loop/switch region; other site 698936018772 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698936018773 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936018774 Walker A/P-loop; other site 698936018775 ATP binding site [chemical binding]; other site 698936018776 Q-loop/lid; other site 698936018777 ABC transporter signature motif; other site 698936018778 Walker B; other site 698936018779 D-loop; other site 698936018780 H-loop/switch region; other site 698936018781 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936018782 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698936018783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936018784 dimer interface [polypeptide binding]; other site 698936018785 conserved gate region; other site 698936018786 putative PBP binding loops; other site 698936018787 ABC-ATPase subunit interface; other site 698936018788 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936018789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936018790 dimer interface [polypeptide binding]; other site 698936018791 conserved gate region; other site 698936018792 putative PBP binding loops; other site 698936018793 ABC-ATPase subunit interface; other site 698936018794 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936018795 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 698936018796 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 698936018797 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698936018798 putative active site [active] 698936018799 catalytic residue [active] 698936018800 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936018801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936018802 DNA-binding site [nucleotide binding]; DNA binding site 698936018803 FCD domain; Region: FCD; pfam07729 698936018804 Ferritin-like domain; Region: Ferritin_2; pfam13668 698936018805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936018806 putative substrate translocation pore; other site 698936018807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936018808 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 698936018809 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698936018810 dimer interface [polypeptide binding]; other site 698936018811 active site 698936018812 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 698936018813 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 698936018814 NAD binding site [chemical binding]; other site 698936018815 homodimer interface [polypeptide binding]; other site 698936018816 homotetramer interface [polypeptide binding]; other site 698936018817 active site 698936018818 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 698936018819 Helix-turn-helix domain; Region: HTH_18; pfam12833 698936018820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936018821 Uncharacterized conserved protein [Function unknown]; Region: COG5654 698936018822 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 698936018823 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 698936018824 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 698936018825 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 698936018826 active site pocket [active] 698936018827 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698936018828 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 698936018829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936018830 dimer interface [polypeptide binding]; other site 698936018831 conserved gate region; other site 698936018832 putative PBP binding loops; other site 698936018833 ABC-ATPase subunit interface; other site 698936018834 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 698936018835 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 698936018836 Walker A/P-loop; other site 698936018837 ATP binding site [chemical binding]; other site 698936018838 Q-loop/lid; other site 698936018839 ABC transporter signature motif; other site 698936018840 Walker B; other site 698936018841 D-loop; other site 698936018842 H-loop/switch region; other site 698936018843 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 698936018844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936018845 dimer interface [polypeptide binding]; other site 698936018846 conserved gate region; other site 698936018847 ABC-ATPase subunit interface; other site 698936018848 Isochorismatase family; Region: Isochorismatase; pfam00857 698936018849 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 698936018850 catalytic triad [active] 698936018851 conserved cis-peptide bond; other site 698936018852 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698936018853 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698936018854 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 698936018855 active site 698936018856 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 698936018857 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 698936018858 conserved cys residue [active] 698936018859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936018860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936018861 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 698936018862 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698936018863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936018864 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698936018865 dimerization interface [polypeptide binding]; other site 698936018866 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936018867 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698936018868 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 698936018869 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 698936018870 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698936018871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936018872 putative substrate translocation pore; other site 698936018873 Uncharacterized conserved protein [Function unknown]; Region: COG4925 698936018874 Cytochrome c2 [Energy production and conversion]; Region: COG3474 698936018875 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936018876 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698936018877 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698936018878 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936018879 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698936018880 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 698936018881 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936018882 catalytic loop [active] 698936018883 iron binding site [ion binding]; other site 698936018884 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698936018885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936018886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936018887 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698936018888 putative effector binding pocket; other site 698936018889 putative dimerization interface [polypeptide binding]; other site 698936018890 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 698936018891 homodimer interface [polypeptide binding]; other site 698936018892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936018893 catalytic residue [active] 698936018894 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698936018895 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 698936018896 putative C-terminal domain interface [polypeptide binding]; other site 698936018897 putative GSH binding site (G-site) [chemical binding]; other site 698936018898 putative dimer interface [polypeptide binding]; other site 698936018899 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 698936018900 putative N-terminal domain interface [polypeptide binding]; other site 698936018901 putative dimer interface [polypeptide binding]; other site 698936018902 putative substrate binding pocket (H-site) [chemical binding]; other site 698936018903 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 698936018904 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 698936018905 [2Fe-2S] cluster binding site [ion binding]; other site 698936018906 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698936018907 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 698936018908 FMN-binding pocket [chemical binding]; other site 698936018909 flavin binding motif; other site 698936018910 phosphate binding motif [ion binding]; other site 698936018911 beta-alpha-beta structure motif; other site 698936018912 NAD binding pocket [chemical binding]; other site 698936018913 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936018914 catalytic loop [active] 698936018915 iron binding site [ion binding]; other site 698936018916 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 698936018917 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698936018918 hydrophobic ligand binding site; other site 698936018919 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 698936018920 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698936018921 hydrophobic ligand binding site; other site 698936018922 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936018923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936018924 DNA-binding site [nucleotide binding]; DNA binding site 698936018925 FCD domain; Region: FCD; pfam07729 698936018926 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 698936018927 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 698936018928 putative ligand binding site [chemical binding]; other site 698936018929 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 698936018930 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936018931 Walker A/P-loop; other site 698936018932 ATP binding site [chemical binding]; other site 698936018933 Q-loop/lid; other site 698936018934 ABC transporter signature motif; other site 698936018935 Walker B; other site 698936018936 D-loop; other site 698936018937 H-loop/switch region; other site 698936018938 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936018939 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936018940 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698936018941 TM-ABC transporter signature motif; other site 698936018942 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936018943 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698936018944 TM-ABC transporter signature motif; other site 698936018945 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 698936018946 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 698936018947 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 698936018948 4Fe-4S binding domain; Region: Fer4; pfam00037 698936018949 FOG: CBS domain [General function prediction only]; Region: COG0517 698936018950 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 698936018951 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 698936018952 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936018953 catalytic loop [active] 698936018954 iron binding site [ion binding]; other site 698936018955 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 698936018956 4Fe-4S binding domain; Region: Fer4; pfam00037 698936018957 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 698936018958 [4Fe-4S] binding site [ion binding]; other site 698936018959 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 698936018960 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 698936018961 SLBB domain; Region: SLBB; pfam10531 698936018962 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 698936018963 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 698936018964 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 698936018965 putative dimer interface [polypeptide binding]; other site 698936018966 [2Fe-2S] cluster binding site [ion binding]; other site 698936018967 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 698936018968 NADH dehydrogenase subunit D; Validated; Region: PRK06075 698936018969 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 698936018970 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 698936018971 NADH dehydrogenase subunit B; Validated; Region: PRK06411 698936018972 NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838 698936018973 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 698936018974 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698936018975 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 698936018976 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698936018977 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 698936018978 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698936018979 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 698936018980 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698936018981 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713 698936018982 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 698936018983 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 698936018984 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 698936018985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936018986 S-adenosylmethionine binding site [chemical binding]; other site 698936018987 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936018988 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 698936018989 putative active site [active] 698936018990 heme pocket [chemical binding]; other site 698936018991 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 698936018992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936018993 putative active site [active] 698936018994 heme pocket [chemical binding]; other site 698936018995 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936018996 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 698936018997 putative active site [active] 698936018998 heme pocket [chemical binding]; other site 698936018999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936019000 putative active site [active] 698936019001 heme pocket [chemical binding]; other site 698936019002 PAS fold; Region: PAS_4; pfam08448 698936019003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936019004 putative active site [active] 698936019005 heme pocket [chemical binding]; other site 698936019006 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698936019007 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698936019008 metal binding site [ion binding]; metal-binding site 698936019009 active site 698936019010 I-site; other site 698936019011 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698936019012 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698936019013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936019014 active site 698936019015 phosphorylation site [posttranslational modification] 698936019016 intermolecular recognition site; other site 698936019017 dimerization interface [polypeptide binding]; other site 698936019018 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936019019 DNA binding residues [nucleotide binding] 698936019020 dimerization interface [polypeptide binding]; other site 698936019021 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 698936019022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936019023 TPR repeat; Region: TPR_11; pfam13414 698936019024 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 698936019025 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698936019026 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698936019027 dimer interface [polypeptide binding]; other site 698936019028 putative CheW interface [polypeptide binding]; other site 698936019029 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 698936019030 putative binding surface; other site 698936019031 active site 698936019032 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 698936019033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936019034 ATP binding site [chemical binding]; other site 698936019035 Mg2+ binding site [ion binding]; other site 698936019036 G-X-G motif; other site 698936019037 CheW-like domain; Region: CheW; pfam01584 698936019038 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698936019039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936019040 active site 698936019041 phosphorylation site [posttranslational modification] 698936019042 intermolecular recognition site; other site 698936019043 dimerization interface [polypeptide binding]; other site 698936019044 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 698936019045 CheB methylesterase; Region: CheB_methylest; pfam01339 698936019046 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 698936019047 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 698936019048 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698936019049 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 698936019050 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 698936019051 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698936019052 ATP binding site [chemical binding]; other site 698936019053 Walker A motif; other site 698936019054 hexamer interface [polypeptide binding]; other site 698936019055 Walker B motif; other site 698936019056 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 698936019057 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 698936019058 TadE-like protein; Region: TadE; pfam07811 698936019059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 698936019060 active site 698936019061 dimerization interface [polypeptide binding]; other site 698936019062 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 698936019063 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 698936019064 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 698936019065 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 698936019066 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 698936019067 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 698936019068 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 698936019069 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 698936019070 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 698936019071 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698936019072 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936019073 cyclase homology domain; Region: CHD; cd07302 698936019074 nucleotidyl binding site; other site 698936019075 metal binding site [ion binding]; metal-binding site 698936019076 dimer interface [polypeptide binding]; other site 698936019077 Predicted integral membrane protein [Function unknown]; Region: COG5616 698936019078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936019079 TPR motif; other site 698936019080 TPR repeat; Region: TPR_11; pfam13414 698936019081 binding surface 698936019082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936019083 binding surface 698936019084 TPR motif; other site 698936019085 Tetratricopeptide repeat; Region: TPR_16; pfam13432 698936019086 Transposase; Region: HTH_Tnp_1; cl17663 698936019087 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 698936019088 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 698936019089 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 698936019090 active site 698936019091 catalytic residues [active] 698936019092 Predicted ester cyclase [General function prediction only]; Region: COG5485 698936019093 Sterile alpha motif; Region: SAM; smart00454 698936019094 SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487 698936019095 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936019096 cyclase homology domain; Region: CHD; cd07302 698936019097 nucleotidyl binding site; other site 698936019098 metal binding site [ion binding]; metal-binding site 698936019099 dimer interface [polypeptide binding]; other site 698936019100 Predicted ATPase [General function prediction only]; Region: COG3899 698936019101 AAA ATPase domain; Region: AAA_16; pfam13191 698936019102 Predicted ATPase [General function prediction only]; Region: COG3903 698936019103 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698936019104 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698936019105 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 698936019106 [2Fe-2S] cluster binding site [ion binding]; other site 698936019107 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 698936019108 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 698936019109 putative cation:proton antiport protein; Provisional; Region: PRK10669 698936019110 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 698936019111 TrkA-N domain; Region: TrkA_N; pfam02254 698936019112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936019113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019114 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698936019115 putative effector binding pocket; other site 698936019116 dimerization interface [polypeptide binding]; other site 698936019117 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698936019118 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 698936019119 FMN binding site [chemical binding]; other site 698936019120 active site 698936019121 substrate binding site [chemical binding]; other site 698936019122 catalytic residue [active] 698936019123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936019124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019125 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 698936019126 substrate binding pocket [chemical binding]; other site 698936019127 dimerization interface [polypeptide binding]; other site 698936019128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 698936019129 short chain dehydrogenase; Provisional; Region: PRK06523 698936019130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936019131 NAD(P) binding site [chemical binding]; other site 698936019132 active site 698936019133 SnoaL-like domain; Region: SnoaL_2; pfam12680 698936019134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936019135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019136 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698936019137 putative effector binding pocket; other site 698936019138 putative dimerization interface [polypeptide binding]; other site 698936019139 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 698936019140 Transposase domain (DUF772); Region: DUF772; pfam05598 698936019141 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 698936019142 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 698936019143 putative homodimer interface [polypeptide binding]; other site 698936019144 putative homotetramer interface [polypeptide binding]; other site 698936019145 putative metal binding site [ion binding]; other site 698936019146 putative homodimer-homodimer interface [polypeptide binding]; other site 698936019147 putative allosteric switch controlling residues; other site 698936019148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936019149 putative substrate translocation pore; other site 698936019150 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 698936019151 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 698936019152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936019153 Walker A/P-loop; other site 698936019154 ATP binding site [chemical binding]; other site 698936019155 Q-loop/lid; other site 698936019156 ABC transporter signature motif; other site 698936019157 Walker B; other site 698936019158 D-loop; other site 698936019159 H-loop/switch region; other site 698936019160 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 698936019161 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698936019162 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936019163 Walker A/P-loop; other site 698936019164 ATP binding site [chemical binding]; other site 698936019165 Q-loop/lid; other site 698936019166 ABC transporter signature motif; other site 698936019167 Walker B; other site 698936019168 D-loop; other site 698936019169 H-loop/switch region; other site 698936019170 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936019171 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698936019172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019173 dimer interface [polypeptide binding]; other site 698936019174 conserved gate region; other site 698936019175 putative PBP binding loops; other site 698936019176 ABC-ATPase subunit interface; other site 698936019177 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936019178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019179 dimer interface [polypeptide binding]; other site 698936019180 conserved gate region; other site 698936019181 putative PBP binding loops; other site 698936019182 ABC-ATPase subunit interface; other site 698936019183 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936019184 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 698936019185 substrate binding site [chemical binding]; other site 698936019186 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 698936019187 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 698936019188 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936019189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936019190 DNA-binding site [nucleotide binding]; DNA binding site 698936019191 FCD domain; Region: FCD; pfam07729 698936019192 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698936019193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698936019194 Coenzyme A binding pocket [chemical binding]; other site 698936019195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698936019196 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698936019197 Helix-turn-helix domain; Region: HTH_38; pfam13936 698936019198 Homeodomain-like domain; Region: HTH_32; pfam13565 698936019199 Integrase core domain; Region: rve; pfam00665 698936019200 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 698936019201 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 698936019202 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 698936019203 putative DNA binding site [nucleotide binding]; other site 698936019204 putative homodimer interface [polypeptide binding]; other site 698936019205 Protein of unknown function (DUF768); Region: DUF768; pfam05589 698936019206 GXWXG protein; Region: GXWXG; pfam14231 698936019207 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 698936019208 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 698936019209 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 698936019210 putative active site [active] 698936019211 homotetrameric interface [polypeptide binding]; other site 698936019212 metal binding site [ion binding]; metal-binding site 698936019213 PRC-barrel domain; Region: PRC; pfam05239 698936019214 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 698936019215 SnoaL-like domain; Region: SnoaL_3; pfam13474 698936019216 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698936019217 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 698936019218 AsnC family; Region: AsnC_trans_reg; pfam01037 698936019219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698936019220 S-adenosylmethionine binding site [chemical binding]; other site 698936019221 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698936019222 catalytic core [active] 698936019223 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698936019224 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698936019225 Walker A/P-loop; other site 698936019226 ATP binding site [chemical binding]; other site 698936019227 Q-loop/lid; other site 698936019228 ABC transporter signature motif; other site 698936019229 Walker B; other site 698936019230 D-loop; other site 698936019231 H-loop/switch region; other site 698936019232 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 698936019233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019234 dimer interface [polypeptide binding]; other site 698936019235 conserved gate region; other site 698936019236 putative PBP binding loops; other site 698936019237 ABC-ATPase subunit interface; other site 698936019238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019239 dimer interface [polypeptide binding]; other site 698936019240 conserved gate region; other site 698936019241 putative PBP binding loops; other site 698936019242 ABC-ATPase subunit interface; other site 698936019243 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698936019244 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698936019245 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698936019246 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698936019247 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 698936019248 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698936019249 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698936019250 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 698936019251 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698936019252 NADP binding site [chemical binding]; other site 698936019253 homodimer interface [polypeptide binding]; other site 698936019254 active site 698936019255 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 698936019256 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 698936019257 putative NAD(P) binding site [chemical binding]; other site 698936019258 catalytic Zn binding site [ion binding]; other site 698936019259 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 698936019260 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 698936019261 putative ligand binding site [chemical binding]; other site 698936019262 NAD binding site [chemical binding]; other site 698936019263 catalytic site [active] 698936019264 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698936019265 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698936019266 Walker A/P-loop; other site 698936019267 ATP binding site [chemical binding]; other site 698936019268 Q-loop/lid; other site 698936019269 ABC transporter signature motif; other site 698936019270 Walker B; other site 698936019271 D-loop; other site 698936019272 H-loop/switch region; other site 698936019273 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936019274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019275 dimer interface [polypeptide binding]; other site 698936019276 conserved gate region; other site 698936019277 putative PBP binding loops; other site 698936019278 ABC-ATPase subunit interface; other site 698936019279 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936019280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019281 dimer interface [polypeptide binding]; other site 698936019282 conserved gate region; other site 698936019283 putative PBP binding loops; other site 698936019284 ABC-ATPase subunit interface; other site 698936019285 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 698936019286 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698936019287 Zn2+ binding site [ion binding]; other site 698936019288 Mg2+ binding site [ion binding]; other site 698936019289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019290 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 698936019291 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698936019292 dimerization interface [polypeptide binding]; other site 698936019293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 698936019294 YheO-like PAS domain; Region: PAS_6; pfam08348 698936019295 HTH domain; Region: HTH_22; pfam13309 698936019296 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698936019297 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936019298 substrate binding pocket [chemical binding]; other site 698936019299 membrane-bound complex binding site; other site 698936019300 hinge residues; other site 698936019301 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936019302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019303 dimer interface [polypeptide binding]; other site 698936019304 conserved gate region; other site 698936019305 putative PBP binding loops; other site 698936019306 ABC-ATPase subunit interface; other site 698936019307 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936019308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019309 dimer interface [polypeptide binding]; other site 698936019310 conserved gate region; other site 698936019311 putative PBP binding loops; other site 698936019312 ABC-ATPase subunit interface; other site 698936019313 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698936019314 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698936019315 Walker A/P-loop; other site 698936019316 ATP binding site [chemical binding]; other site 698936019317 Q-loop/lid; other site 698936019318 ABC transporter signature motif; other site 698936019319 Walker B; other site 698936019320 D-loop; other site 698936019321 H-loop/switch region; other site 698936019322 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 698936019323 ornithine cyclodeaminase; Validated; Region: PRK06823 698936019324 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698936019325 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 698936019326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936019327 catalytic residue [active] 698936019328 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698936019329 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698936019330 active site 698936019331 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 698936019332 Predicted transcriptional regulator [Transcription]; Region: COG2944 698936019333 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698936019334 non-specific DNA binding site [nucleotide binding]; other site 698936019335 salt bridge; other site 698936019336 sequence-specific DNA binding site [nucleotide binding]; other site 698936019337 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698936019338 Helix-turn-helix domain; Region: HTH_38; pfam13936 698936019339 Homeodomain-like domain; Region: HTH_32; pfam13565 698936019340 Integrase core domain; Region: rve; pfam00665 698936019341 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 698936019342 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 698936019343 active site 698936019344 putative substrate binding pocket [chemical binding]; other site 698936019345 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698936019346 active site 698936019347 tetramer interface [polypeptide binding]; other site 698936019348 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698936019349 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936019350 active site 698936019351 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936019352 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698936019353 TM-ABC transporter signature motif; other site 698936019354 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698936019355 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698936019356 TM-ABC transporter signature motif; other site 698936019357 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 698936019358 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698936019359 Walker A/P-loop; other site 698936019360 ATP binding site [chemical binding]; other site 698936019361 Q-loop/lid; other site 698936019362 ABC transporter signature motif; other site 698936019363 Walker B; other site 698936019364 D-loop; other site 698936019365 H-loop/switch region; other site 698936019366 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698936019367 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698936019368 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 698936019369 NIPSNAP; Region: NIPSNAP; pfam07978 698936019370 choline dehydrogenase; Validated; Region: PRK02106 698936019371 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698936019372 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 698936019373 ligand binding site [chemical binding]; other site 698936019374 active site 698936019375 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698936019376 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936019377 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 698936019378 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 698936019379 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698936019380 phosphate binding site [ion binding]; other site 698936019381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936019382 DNA-binding site [nucleotide binding]; DNA binding site 698936019383 UTRA domain; Region: UTRA; pfam07702 698936019384 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698936019385 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698936019386 NAD(P) binding site [chemical binding]; other site 698936019387 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 698936019388 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698936019389 NAD binding site [chemical binding]; other site 698936019390 dimerization interface [polypeptide binding]; other site 698936019391 product binding site; other site 698936019392 substrate binding site [chemical binding]; other site 698936019393 zinc binding site [ion binding]; other site 698936019394 catalytic residues [active] 698936019395 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936019396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019397 dimer interface [polypeptide binding]; other site 698936019398 conserved gate region; other site 698936019399 putative PBP binding loops; other site 698936019400 ABC-ATPase subunit interface; other site 698936019401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019402 dimer interface [polypeptide binding]; other site 698936019403 conserved gate region; other site 698936019404 putative PBP binding loops; other site 698936019405 ABC-ATPase subunit interface; other site 698936019406 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698936019407 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698936019408 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698936019409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698936019410 Walker A/P-loop; other site 698936019411 ATP binding site [chemical binding]; other site 698936019412 Q-loop/lid; other site 698936019413 ABC transporter signature motif; other site 698936019414 Walker B; other site 698936019415 D-loop; other site 698936019416 H-loop/switch region; other site 698936019417 TOBE domain; Region: TOBE_2; pfam08402 698936019418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936019419 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 698936019420 NAD(P) binding site [chemical binding]; other site 698936019421 active site 698936019422 histidinol-phosphate aminotransferase; Provisional; Region: PRK05166 698936019423 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936019424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936019425 homodimer interface [polypeptide binding]; other site 698936019426 catalytic residue [active] 698936019427 Transmembrane secretion effector; Region: MFS_3; pfam05977 698936019428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936019429 putative substrate translocation pore; other site 698936019430 Predicted membrane protein [Function unknown]; Region: COG2259 698936019431 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 698936019432 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 698936019433 active site 698936019434 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 698936019435 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 698936019436 Isochorismatase family; Region: Isochorismatase; pfam00857 698936019437 catalytic triad [active] 698936019438 dimer interface [polypeptide binding]; other site 698936019439 conserved cis-peptide bond; other site 698936019440 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 698936019441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698936019442 Zn binding site [ion binding]; other site 698936019443 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 698936019444 Zn binding site [ion binding]; other site 698936019445 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936019446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019447 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698936019448 putative effector binding pocket; other site 698936019449 dimerization interface [polypeptide binding]; other site 698936019450 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 698936019451 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 698936019452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 698936019453 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698936019454 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698936019455 Homeodomain-like domain; Region: HTH_23; cl17451 698936019456 Predicted acetyltransferase [General function prediction only]; Region: COG3153 698936019457 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698936019458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936019459 NAD(P) binding site [chemical binding]; other site 698936019460 active site 698936019461 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 698936019462 Isochorismatase family; Region: Isochorismatase; pfam00857 698936019463 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 698936019464 catalytic triad [active] 698936019465 dimer interface [polypeptide binding]; other site 698936019466 conserved cis-peptide bond; other site 698936019467 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936019468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019469 LysR substrate binding domain; Region: LysR_substrate; pfam03466 698936019470 dimerization interface [polypeptide binding]; other site 698936019471 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936019472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019473 LysR substrate binding domain; Region: LysR_substrate; pfam03466 698936019474 dimerization interface [polypeptide binding]; other site 698936019475 Pirin-related protein [General function prediction only]; Region: COG1741 698936019476 Pirin; Region: Pirin; pfam02678 698936019477 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 698936019478 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 698936019479 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 698936019480 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698936019481 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936019482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019483 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 698936019484 substrate binding pocket [chemical binding]; other site 698936019485 dimerization interface [polypeptide binding]; other site 698936019486 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 698936019487 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 698936019488 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698936019489 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698936019490 classical (c) SDRs; Region: SDR_c; cd05233 698936019491 NAD(P) binding site [chemical binding]; other site 698936019492 active site 698936019493 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 698936019494 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 698936019495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936019496 NAD(P) binding site [chemical binding]; other site 698936019497 active site 698936019498 Predicted membrane protein [Function unknown]; Region: COG2259 698936019499 short chain dehydrogenase; Provisional; Region: PRK06180 698936019500 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 698936019501 NADP binding site [chemical binding]; other site 698936019502 active site 698936019503 steroid binding site; other site 698936019504 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698936019505 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 698936019506 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 698936019507 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698936019508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698936019509 NAD(P) binding site [chemical binding]; other site 698936019510 active site 698936019511 Cupin; Region: Cupin_6; pfam12852 698936019512 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698936019513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936019514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936019515 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 698936019516 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 698936019517 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 698936019518 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 698936019519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936019520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019521 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698936019522 putative effector binding pocket; other site 698936019523 putative dimerization interface [polypeptide binding]; other site 698936019524 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698936019525 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 698936019526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019527 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 698936019528 putative dimerization interface [polypeptide binding]; other site 698936019529 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 698936019530 active sites [active] 698936019531 tetramer interface [polypeptide binding]; other site 698936019532 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698936019533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019534 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 698936019535 dimerization interface [polypeptide binding]; other site 698936019536 substrate binding pocket [chemical binding]; other site 698936019537 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698936019538 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698936019539 Cupin domain; Region: Cupin_2; cl17218 698936019540 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698936019541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019542 conserved gate region; other site 698936019543 dimer interface [polypeptide binding]; other site 698936019544 putative PBP binding loops; other site 698936019545 ABC-ATPase subunit interface; other site 698936019546 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698936019547 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 698936019548 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698936019549 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936019550 Walker A/P-loop; other site 698936019551 ATP binding site [chemical binding]; other site 698936019552 Q-loop/lid; other site 698936019553 ABC transporter signature motif; other site 698936019554 Walker B; other site 698936019555 D-loop; other site 698936019556 H-loop/switch region; other site 698936019557 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698936019558 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698936019559 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698936019560 Walker A/P-loop; other site 698936019561 ATP binding site [chemical binding]; other site 698936019562 Q-loop/lid; other site 698936019563 ABC transporter signature motif; other site 698936019564 Walker B; other site 698936019565 D-loop; other site 698936019566 H-loop/switch region; other site 698936019567 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698936019568 Uncharacterized conserved protein [Function unknown]; Region: COG3246 698936019569 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 698936019570 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 698936019571 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 698936019572 nudix motif; other site 698936019573 Cupin; Region: Cupin_6; pfam12852 698936019574 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698936019575 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936019576 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936019577 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 698936019578 dimer interface [polypeptide binding]; other site 698936019579 FMN binding site [chemical binding]; other site 698936019580 Uncharacterized conserved protein [Function unknown]; Region: COG2128 698936019581 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 698936019582 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 698936019583 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 698936019584 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698936019585 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 698936019586 putative NAD(P) binding site [chemical binding]; other site 698936019587 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 698936019588 Transposase domain (DUF772); Region: DUF772; pfam05598 698936019589 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 698936019590 Cupin domain; Region: Cupin_2; cl17218 698936019591 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698936019592 Helix-turn-helix domain; Region: HTH_38; pfam13936 698936019593 Homeodomain-like domain; Region: HTH_32; pfam13565 698936019594 Integrase core domain; Region: rve; pfam00665 698936019595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 698936019596 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698936019597 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 698936019598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698936019599 PAS domain; Region: PAS_9; pfam13426 698936019600 putative active site [active] 698936019601 heme pocket [chemical binding]; other site 698936019602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698936019603 Histidine kinase; Region: HisKA_2; pfam07568 698936019604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936019605 ATP binding site [chemical binding]; other site 698936019606 Mg2+ binding site [ion binding]; other site 698936019607 G-X-G motif; other site 698936019608 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698936019609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936019610 active site 698936019611 phosphorylation site [posttranslational modification] 698936019612 intermolecular recognition site; other site 698936019613 dimerization interface [polypeptide binding]; other site 698936019614 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698936019615 DNA-binding site [nucleotide binding]; DNA binding site 698936019616 RNA-binding motif; other site 698936019617 Thioredoxin; Region: Thioredoxin_4; cl17273 698936019618 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698936019619 MULE transposase domain; Region: MULE; pfam10551 698936019620 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936019621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936019622 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 698936019623 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 698936019624 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 698936019625 Autotransporter beta-domain; Region: Autotransporter; pfam03797 698936019626 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698936019627 homotrimer interaction site [polypeptide binding]; other site 698936019628 putative active site [active] 698936019629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 698936019630 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 698936019631 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 698936019632 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 698936019633 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 698936019634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019635 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 698936019636 putative dimerization interface [polypeptide binding]; other site 698936019637 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 698936019638 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698936019639 NAD(P) binding site [chemical binding]; other site 698936019640 catalytic residues [active] 698936019641 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 698936019642 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698936019643 putative active site [active] 698936019644 catalytic residue [active] 698936019645 aspartate aminotransferase; Provisional; Region: PRK05764 698936019646 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698936019647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936019648 homodimer interface [polypeptide binding]; other site 698936019649 catalytic residue [active] 698936019650 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 698936019651 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 698936019652 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 698936019653 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 698936019654 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 698936019655 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698936019656 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698936019657 substrate binding pocket [chemical binding]; other site 698936019658 membrane-bound complex binding site; other site 698936019659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019660 dimer interface [polypeptide binding]; other site 698936019661 conserved gate region; other site 698936019662 putative PBP binding loops; other site 698936019663 ABC-ATPase subunit interface; other site 698936019664 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698936019665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019666 dimer interface [polypeptide binding]; other site 698936019667 conserved gate region; other site 698936019668 putative PBP binding loops; other site 698936019669 ABC-ATPase subunit interface; other site 698936019670 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698936019671 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698936019672 Walker A/P-loop; other site 698936019673 ATP binding site [chemical binding]; other site 698936019674 Q-loop/lid; other site 698936019675 ABC transporter signature motif; other site 698936019676 Walker B; other site 698936019677 D-loop; other site 698936019678 H-loop/switch region; other site 698936019679 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698936019680 homotrimer interaction site [polypeptide binding]; other site 698936019681 putative active site [active] 698936019682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936019683 DNA-binding site [nucleotide binding]; DNA binding site 698936019684 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698936019685 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698936019686 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 698936019687 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698936019688 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698936019689 HlyD family secretion protein; Region: HlyD_3; pfam13437 698936019690 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 698936019691 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 698936019692 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 698936019693 arginine deiminase; Provisional; Region: PRK01388 698936019694 Predicted membrane protein [Function unknown]; Region: COG4803 698936019695 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 698936019696 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698936019697 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698936019698 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698936019699 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 698936019700 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 698936019701 active site 698936019702 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 698936019703 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 698936019704 TPR repeat; Region: TPR_11; pfam13414 698936019705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698936019706 TPR motif; other site 698936019707 binding surface 698936019708 Tetratricopeptide repeat; Region: TPR_16; pfam13432 698936019709 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698936019710 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698936019711 motif II; other site 698936019712 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 698936019713 Sulfatase; Region: Sulfatase; pfam00884 698936019714 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698936019715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698936019716 dimer interface [polypeptide binding]; other site 698936019717 phosphorylation site [posttranslational modification] 698936019718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698936019719 ATP binding site [chemical binding]; other site 698936019720 Mg2+ binding site [ion binding]; other site 698936019721 G-X-G motif; other site 698936019722 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 698936019723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936019724 active site 698936019725 phosphorylation site [posttranslational modification] 698936019726 intermolecular recognition site; other site 698936019727 dimerization interface [polypeptide binding]; other site 698936019728 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698936019729 DNA binding residues [nucleotide binding] 698936019730 dimerization interface [polypeptide binding]; other site 698936019731 Response regulator receiver domain; Region: Response_reg; pfam00072 698936019732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698936019733 active site 698936019734 phosphorylation site [posttranslational modification] 698936019735 intermolecular recognition site; other site 698936019736 dimerization interface [polypeptide binding]; other site 698936019737 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698936019738 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698936019739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698936019740 HWE histidine kinase; Region: HWE_HK; pfam07536 698936019741 Transposase; Region: HTH_Tnp_1; cl17663 698936019742 Predicted membrane protein [Function unknown]; Region: COG4292 698936019743 Predicted transcriptional regulator [Transcription]; Region: COG4957 698936019744 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 698936019745 active site 698936019746 Mn binding site [ion binding]; other site 698936019747 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 698936019748 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698936019749 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 698936019750 active site 698936019751 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 698936019752 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698936019753 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 698936019754 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698936019755 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 698936019756 active site 698936019757 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 698936019758 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936019759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019760 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698936019761 putative effector binding pocket; other site 698936019762 dimerization interface [polypeptide binding]; other site 698936019763 Isochorismatase family; Region: Isochorismatase; pfam00857 698936019764 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 698936019765 catalytic triad [active] 698936019766 conserved cis-peptide bond; other site 698936019767 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 698936019768 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 698936019769 conserved cys residue [active] 698936019770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936019771 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 698936019772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698936019773 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 698936019774 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936019775 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698936019776 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 698936019777 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698936019778 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 698936019779 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698936019780 NAD(P) binding site [chemical binding]; other site 698936019781 catalytic residues [active] 698936019782 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 698936019783 iron-sulfur cluster [ion binding]; other site 698936019784 [2Fe-2S] cluster binding site [ion binding]; other site 698936019785 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 698936019786 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698936019787 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 698936019788 FAD binding pocket [chemical binding]; other site 698936019789 FAD binding motif [chemical binding]; other site 698936019790 phosphate binding motif [ion binding]; other site 698936019791 beta-alpha-beta structure motif; other site 698936019792 NAD binding pocket [chemical binding]; other site 698936019793 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698936019794 catalytic loop [active] 698936019795 iron binding site [ion binding]; other site 698936019796 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936019797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019798 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698936019799 dimerization interface [polypeptide binding]; other site 698936019800 Predicted membrane protein [Function unknown]; Region: COG2855 698936019801 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 698936019802 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 698936019803 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 698936019804 FAD binding pocket [chemical binding]; other site 698936019805 FAD binding motif [chemical binding]; other site 698936019806 phosphate binding motif [ion binding]; other site 698936019807 NAD binding pocket [chemical binding]; other site 698936019808 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698936019809 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698936019810 Walker A/P-loop; other site 698936019811 ATP binding site [chemical binding]; other site 698936019812 Q-loop/lid; other site 698936019813 ABC transporter signature motif; other site 698936019814 Walker B; other site 698936019815 D-loop; other site 698936019816 H-loop/switch region; other site 698936019817 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698936019818 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698936019819 ABC-ATPase subunit interface; other site 698936019820 dimer interface [polypeptide binding]; other site 698936019821 putative PBP binding regions; other site 698936019822 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698936019823 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698936019824 ABC-ATPase subunit interface; other site 698936019825 dimer interface [polypeptide binding]; other site 698936019826 putative PBP binding regions; other site 698936019827 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698936019828 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698936019829 intersubunit interface [polypeptide binding]; other site 698936019830 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 698936019831 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 698936019832 N-terminal plug; other site 698936019833 ligand-binding site [chemical binding]; other site 698936019834 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698936019835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936019836 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936019837 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698936019838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019839 dimer interface [polypeptide binding]; other site 698936019840 conserved gate region; other site 698936019841 putative PBP binding loops; other site 698936019842 ABC-ATPase subunit interface; other site 698936019843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698936019844 dimer interface [polypeptide binding]; other site 698936019845 conserved gate region; other site 698936019846 putative PBP binding loops; other site 698936019847 ABC-ATPase subunit interface; other site 698936019848 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698936019849 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 698936019850 Walker A/P-loop; other site 698936019851 ATP binding site [chemical binding]; other site 698936019852 Q-loop/lid; other site 698936019853 ABC transporter signature motif; other site 698936019854 Walker B; other site 698936019855 D-loop; other site 698936019856 H-loop/switch region; other site 698936019857 TOBE domain; Region: TOBE_2; pfam08402 698936019858 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698936019859 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698936019860 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698936019861 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698936019862 DNA-binding site [nucleotide binding]; DNA binding site 698936019863 FCD domain; Region: FCD; pfam07729 698936019864 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 698936019865 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698936019866 active site 698936019867 ATP binding site [chemical binding]; other site 698936019868 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 698936019869 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698936019870 inhibitor-cofactor binding pocket; inhibition site 698936019871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698936019872 catalytic residue [active] 698936019873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 698936019874 Predicted membrane protein [Function unknown]; Region: COG2261 698936019875 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698936019876 active site 698936019877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 698936019878 Predicted membrane protein [Function unknown]; Region: COG4125 698936019879 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 698936019880 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 698936019881 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936019882 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019883 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698936019884 dimerization interface [polypeptide binding]; other site 698936019885 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698936019886 MULE transposase domain; Region: MULE; pfam10551 698936019887 Sterile alpha motif; Region: SAM; smart00454 698936019888 SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487 698936019889 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698936019890 cyclase homology domain; Region: CHD; cd07302 698936019891 nucleotidyl binding site; other site 698936019892 metal binding site [ion binding]; metal-binding site 698936019893 dimer interface [polypeptide binding]; other site 698936019894 Predicted ATPase [General function prediction only]; Region: COG3899 698936019895 AAA ATPase domain; Region: AAA_16; pfam13191 698936019896 Predicted ATPase [General function prediction only]; Region: COG3903 698936019897 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 698936019898 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698936019899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 698936019900 Integrase core domain; Region: rve; pfam00665 698936019901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 698936019902 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 698936019903 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 698936019904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698936019905 Walker A motif; other site 698936019906 ATP binding site [chemical binding]; other site 698936019907 Walker B motif; other site 698936019908 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698936019909 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698936019910 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 698936019911 Transmembrane secretion effector; Region: MFS_3; pfam05977 698936019912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698936019913 putative substrate translocation pore; other site 698936019914 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 698936019915 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 698936019916 active site 698936019917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4317 698936019918 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 698936019919 Isochorismatase family; Region: Isochorismatase; pfam00857 698936019920 catalytic triad [active] 698936019921 dimer interface [polypeptide binding]; other site 698936019922 conserved cis-peptide bond; other site 698936019923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936019924 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936019925 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936019926 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936019927 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698936019928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936019929 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936019930 Helix-turn-helix domain; Region: HTH_18; pfam12833 698936019931 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698936019932 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698936019933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698936019934 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698936019935 putative effector binding pocket; other site 698936019936 dimerization interface [polypeptide binding]; other site